Examples of Stem Cell-Based Therapy in Development Stem Cells as Drug-delivery Vehicles to Treat Cancer Approach Enhanced delivery of chemotherapy
Stem cells
Engineering feature
HB1.F3-CD (myc immortalized fetal NSC line)
Cytosine deaminase enzyme to convert 5-FC to 5-FU Carboxylesterase to convert irinotecan to potent SN-38
HB1.F3-CD NSC
High-grade glioma
NCT01172964
High-grade glioma
NCT02192359
HSV-tk suicide gene
Advanced gastrointestinal adenocarcinoma
NCT02008539
Umbilical cord MSCs
Expression of TRAIL
Stage IIIb/IV metastatic lung adenocarcinoma
NCT03298763
Malignant gliomas
NCT03072134
Recurrent ovarian cancer
NCT02068794
Leukaemia
NA (preclinical stage)
HB1.F3-CD NSCs
Delivery of checkpoint inhibitor
Clinical trial ID
Autologous bone marrow MSCs Targeted induction of apoptosis
Delivery of oncolytic virus
Cancer
Adipose MSCs HSCs
CRAd-Survivin-pk7 oncolytic adenovirus Thyroidal sodium iodide symporter-expressing oncolytic measles virus Conjugated platelets with attached PD-1 antibodies
Reference: Erin A. Kimbrel and Robert Lanza, Nature reviews, 2020
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