Stem Cells for Induction of Antigen-specific AntitumourImmunity (Examples)

Examples of Stem Cell-Based Therapy in Development Stem Cells for Induction of Antigen-specific Antitumour Immunity Stem cells

HSCs

Receptor

Antigen specificity (+ feature)

Indication

Stage of development

NY-ESO-1 (with sr39TK suicide gene)

Ovarian, fallopian tube, peritoneal cancer

KK10

HIV

Phase I clinical trial (NCT03691376) Preclinical testing in humanized mice

TCR

HSCs

CAR

CD4 (with C46 fusion)

Simian/human immunodeficiency virus

Non-human primate testing

Adipose MSCs

CAR

GD2 (with TRAIL)

Glioblastoma

In vitro testing

iPSC-derived T cells

CAR

CD19

B cell leukaemia

iPSC-derived NK cells

CAR

Mesothelin

Ovarian cancer

iPSC-derived macrophages

scFv

CD20

B cell leukaemia

Preclinical testing in xenograft model Preclinical testing in xenograft model Preclinical testing in xenograft model

Reference: Erin A. Kimbrel and Robert Lanza, Nature reviews, 2020 9

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Stem Cells for Induction of Antigen-specific AntitumourImmunity (Examples)

Published on Aug 31, 2021

Ella2342

In cell therapy, iPS cell technology has opened huge possibilities for cell therapy and regenerative medicine. There are still significant challenges in gene and cell therapy before these new approaches can enter main stream medicine. Significant safety issues have been reported in some trials and the need for better vectors, delivery techniques and treatment genes are widely recognized. With years of experience in providing high-quality products and services in the field of biopharmaceuticals for customers all over the world, scientists in Creative Biolabs will be more focused on developing first class product and technology to meet the need of stem cell therapy development. https://www.creative-biolabs.com/stem-cell-therapy/

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