Applications of DREADDs

Page 1

List of representative DREADDs. DREADD

Description

Ligand

hM3D(Gq)

Increase Ca2+, Activation

CNO

hM4D(Gi)

Decrease cAMP β/γ-GIRK activation, Inhibitory

CNO

KORD

Decrease cAMP β/γ-GIRK activation, Inhibitory

SALB

To activate neuron activity, choose hM3Dq. To inhibit neuron activity, choose hM4Di.

Fig.7 Mechanism of different variants of DREADDs (hM3Dq and hM4Di).

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02

Chemogenetics


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