The Effects of α7nAChR Specific Conotoxins on the Secretion of Aβ and SLURP-1 in Cancer Cells
Asana Williams Deborah Heyl-Clegg, Hedeel Evans, and Jeffrey Guthrie, faculty mentors Amyloid beta (Aβ) and the nicotinic acetylcholine receptor (nAChR) have been implicated in both Alzheimer’s disease (AD) and cancer. Aβ is a peptide found in AD patients and is present in A549 and H1299 cancer cell lines. nAChR is involved in tumor progression and may contribute to AD via interaction with Aβ. Both Aβ and SLURP-1, a peptide with antiproliferative effects, bind to α7nAChR. In this study, we will synthesize conotoxins, bicyclic peptides from marine animals that inhibit α7nAChR, by solid phase synthesis and cyclize them via two disulfide linkages using a selective protection and oxidation protocol. Effects on secretion of Aβ and SLURP-1 and on cell viability will be determined. Poster / Live Session 1 / 9:10 a.m.
Communication, Media & Theatre Arts “EMU: Return to the Canvas”: The Creative Process of EMU Artists during the Pandemic
Adrian Ace, Sydney Ferguson and Myah Gaither Susan Badger Booth, faculty mentor The students in the Fall 2020 section of the Arts Management class proudly present their final project “EMU: Return to the Canvas,” a documentary following the story of five Eastern Michigan University student artists during the Covid 19 pandemic. This project was conceptualized, developed and produced by the students in this class. The Arts Management class is a part of Eastern Michigan University’s Arts Management & Administration Programs. Students from the class Branding, Marketing and Production groups will be presenting on how this project was developed. Design Expo / Live Group A / 9:15 a.m.
STUDENT ABSTRACTS
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