YL Young Investigator Research Lecture

YL

THE RELATIONSHIP BETWEEN SERUM ANGPTL6 AND THE INCIDENCE OF DIABETES IN HUMAN

H-Y LI

National Taiwan University Hospital, Taipei, Taiwan

The increasing incidence of obesity and type 2 diabetes leads to severe health consequences and to regulate body weight and insulin sensitivity. In cross-sectional studies, serum ANGPTL6 were higher in subjects with obesity, metabolic syndrome, and diabetes than in the healthy group. However, cross-sectional studies are limited in its unclear temporal relationship. Since there is no prospective study to investigate the question, we explored if serum ANGPTL6 could predict incident diabetes in a longitudinal cohort in this study. We recruited 1103 subjects without diabetes at baseline. During an average of 4.3 years of follow-up, 113 subjects develop incident diabetes. Serum ANGPTL6 was associated with age, fasting plasma glucose, OGTT 2hr plasma glucose, and hemoglobin A1c, and was higher in male and subjects with pre-diabetes at baseline. Besides, serum ANGPTL6 was associated with the incidence of diabetes (HR for 1SD increase in serum ANGPTL6, 0.77, 95%CI 0.60-0.98, p<0.05), adjusted for age, gender, family history of diabetes, BMI, hemoglobin A1c, HOMA2-B and HOMA2-IR. In conclusion, we found that serum ANGPTL6 is associated with the incidence of diabetes in human.