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The
th Annual Meeting of April 8-9, 2017 The Endocrine Society and The Diabetes Association of the R.O.C. (Taiwan)
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THE RELATIONSHIP BETWEEN SERUM ANGPTL6 AND THE INCIDENCE OF DIABETES IN HUMAN H-Y LI National Taiwan University Hospital, Taipei, Taiwan
The increasing incidence of obesity and type 2 diabetes leads to severe health consequences and ¿QDQFLDO EXUGHQ RI KHDOWK V\VWHPV /LYHU LV UHFRJQL]HG DV DQ HQGRFULQH RUJDQ DQG D WDUJHW RI PHWDEROLF ¿WQHVV WKDW UHOHDVHV KHSDWRNLQHV $QJLRSRLHWLQ OLNH $1*37/ LV NQRZQ WR EH D QRYHO KHSDWRNLQH to regulate body weight and insulin sensitivity. In cross-sectional studies, serum ANGPTL6 were higher in subjects with obesity, metabolic syndrome, and diabetes than in the healthy group. However, cross-sectional studies are limited in its unclear temporal relationship. Since there is no prospective study to investigate the question, we explored if serum ANGPTL6 could predict incident diabetes in a longitudinal cohort in this study. We recruited 1103 subjects without diabetes at baseline. During an average of 4.3 years of follow-up, 113 subjects develop incident diabetes. Serum ANGPTL6 was associated with age, fasting plasma glucose, OGTT 2hr plasma glucose, and hemoglobin A1c, and was higher in male and subjects with pre-diabetes at baseline. Besides, serum ANGPTL6 was associated with the incidence of diabetes (HR for 1SD increase in serum ANGPTL6, 0.77, 95%CI 0.60-0.98, p<0.05), adjusted for age, gender, family history of diabetes, BMI, hemoglobin A1c, HOMA2-B and HOMA2-IR. In conclusion, we found that serum ANGPTL6 is associated with the incidence of diabetes in human.
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