Spinerepair

SpineRepair Hybrid CMOS‐polymer neural interfaces for restoration of sensorimotor functions after spinal cord injury PI: Stéphanie P. Lacour (EPFL) coPIs: Grégoire Courtine, Silvestro Micera (EPFL) Janos Vöros, Andreas Hierlemann (ETHZ) Jean Luc Nagel (CSEM)

Introduction Context Problematic: -

2.5 million people live with a chronic spinal cord injury (SCI).

Half of them do not recover the ability to stand or walk with current therapeutic interventions.

Approach: -

Robotic training & functional electric stimulation facilitate motor control and functional recovery after SCI.

Missing technological solution: -

Autonomous spinal neuroprosthesis High density conformal electrodes Adaptive stimulation strategies (closed loop)

R. Van Den Brand, in Science, 2012

5/29/2015

Nano Tera Meeting ‐ Spine Repair

2

Spine Repair Consortium Prof. Micera EPFL

Prof. Courtine EPFL

Jean Luc Nagel CSEM Wireless, SoC

Prof. Hielemann ETHZ Electrophysiology IC

Stimulation Pattern model

Prof. Lacour EPFL SMEA & Integration

Prof. Vörös ETHZ SMEA

Wireless Communication

Prof. Courtine EPFL In vivo evaluation Mechanistic framework

Prof. Micera EPFL

Real Time Monitoring

5/29/2015

Nano Tera Meeting ‐ Spine Repair

3

Mechanistic framework Prof. Micera EPFL

Prof. Courtine EPFL

Jean Luc Nagel CSEM Wireless, SoC

Prof. Hielemann ETHZ Electrophysiology IC

Stimulation Pattern model

Prof. Lacour EPFL SMEA & Integration

Prof. Vörös ETHZ SMEA

Wireless Communication

Prof. Courtine EPFL In vivo evaluation Mechanistic framework

Prof. Micera EPFL

Real Time Monitoring

5/29/2015

Nano Tera Meeting ‐ Spine Repair

4

SPINAL CIRCUIT DYNAMICS

5/29/2015

Nano Tera Meeting ‐ Spine Repair

5

SPINAL S P I N ACIRCUIT L C I R CDYNAMICS UIT DYNAMICS

5/29/2015

Nano Tera Meeting ‐ Spine Repair

6

O P T I M A L ELECTRODE E L E C T R O D E C O N F I G U R AT I O N OPTIMAL CONFIGURATION

1 5/29/2015

TARGETED ACTIVATION PROFILES

Nano Tera Meeting ‐ Spine Repair

7

Mechanistic framework Prof. Micera EPFL

Prof. Courtine EPFL

Jean Luc Nagel CSEM Wireless, SoC

Prof. Hielemann ETHZ Electrophysiology IC

Stimulation Pattern model

Prof. Lacour EPFL SMEA & Integration

Prof. Vörös ETHZ SMEA

Wireless Communication

Prof. Courtine EPFL In vivo evaluation Mechanistic framework

Prof. Micera EPFL

Real Time Monitoring

5/29/2015

Nano Tera Meeting ‐ Spine Repair

8

Soft MEA design E-dura

I. MINEV

A. HIRSCH

P. MUSIENKO

MINEV*, MUSIENKO* ET AL. | SCIENCE | 2015 5/29/2015

Nano Tera Meeting ‐ Spine Repair

N. WENGER 9

Soft MEA design Biomechanical matching INSERTION OF IMPLANT control

e‐dura

MECHANICAL MODEL

polyimide

I. MINEV

ELASTICITY

A. HIRSCH

P. MUSIENKO

MINEV*, MUSIENKO* ET AL. | SCIENCE | 2015 5/29/2015

Nano Tera Meeting ‐ Spine Repair

N. WENGER 10

Soft MEA design Chronic Biointegration e-dura I. MINEV

3mm

3mm

Q. BARRAUD

A. HIRSCH

Iba1

GFAP

Iba1

GFAP

P. MUSIENKO

1mm

1mm

MINEV*, MUSIENKO* ET AL. | SCIENCE | 2015 5/29/2015

Nano Tera Meeting ‐ Spine Repair

11

Soft MEA design Nanowire eletride

15v% porous Ag‐ PDMS

F.STAUFFER 20 µm

- Patterning silver nanowires (AgNW) networks using photolithography Toothpick

AgNW tracks (200µm pitch) 5/29/2015

- Characterization of electromechanical performance of high aspect ratio AgNW Tracks

T.KLAS

- Introducing porosity for decreasing electrode impedance Nano Tera Meeting ‐ Spine Repair

12

Mechanistic framework Prof. Micera EPFL

Prof. Courtine EPFL

Jean Luc Nagel CSEM Wireless, SoC

Prof. Hielemann ETHZ Electrophysiology IC

Stimulation Pattern model

Prof. Lacour EPFL SMEA & Integration

Prof. Vörös ETHZ SMEA

Wireless Communication

Prof. Courtine EPFL In vivo evaluation Mechanistic framework

Prof. Micera EPFL

Real Time Monitoring

5/29/2015

Nano Tera Meeting ‐ Spine Repair

13

Stimulator ASIC Layout & Die Photo

Monopolar & biphasic

Bipolar & monophasic

Y.Tao Layout View

Bipolar & monophasic

Die Photo

Bipolar & asymmetrically biphasic

‐ Chip size: 3.3mm x 2.8mm ‐ 15‐channel stimulator

TA O e t a l . | I E E E T B C S | s u b m i t t e d

Stimulator ASIC Initial in-vivo test

Reference Electrode A

+6V

Reference Electrode B 0 V

+12V

(earth ground)

i(t)

To EMG Amplifier

Stimulator Stimulation Electrode A

EMG Electrode B

0 V Rat under Test

Test setup

Produced voltage waveform

Performance equivalent to that of desktop equipment.

Y.Tao

Mechanistic framework Prof. Micera EPFL

Prof. Courtine EPFL

Jean Luc Nagel CSEM Wireless, SoC

Prof. Hielemann ETHZ Electrophysiology IC

Stimulation Pattern model

Prof. Lacour EPFL SMEA & Integration

Prof. Vörös ETHZ SMEA

Wireless Communication

Prof. Courtine EPFL In vivo evaluation Mechanistic framework

Prof. Micera EPFL

Real Time Monitoring

5/29/2015

Nano Tera Meeting ‐ Spine Repair

16

Telemetry & power management

Customised Stimulator

1.8 V (internal icycom VPROG)

icycom receiver

J.L. NAGEL

3 V (main supply)

6V

Antenna & inductive recharge

5/29/2015

12 V

Step-up (COTS)

Nano Tera Meeting ‐ Spine Repair

17

Mechanistic framework Prof. Micera EPFL

Prof. Courtine EPFL

Jean Luc Nagel CSEM Wireless, SoC

Prof. Hielemann ETHZ Electrophysiology IC

Stimulation Pattern model

Prof. Lacour EPFL SMEA & Integration

Prof. Vörös ETHZ SMEA

Wireless Communication

Prof. Courtine EPFL In vivo evaluation Mechanistic framework

Prof. Micera EPFL

Real Time Monitoring

5/29/2015

Nano Tera Meeting ‐ Spine Repair

18

Software Design WENGER ET AL. | SCIENCE TRANS. MED. | 2014

REAL-TIME MONITORING Kinematics (200Hz) EMG (2KHz) GRF (2KHz)

Crest Hip

Interpolate Automatic labeling Online filtering

Knee

RECONSTRUCT BIOMECHANICAL STATE E. MARTIN

Right MG (mV)

8

Right TA (mV)

8

Ground Forces (N) Right foot height (cm)

Extract key features

3

FOOT HEIGHT J. GANDAR

6

X coord

FEEDBACK FORWARD MODEL proprotional integral controller

Z coord Detections

Angle

Event1 Event2

X coord

5/29/2015

REFERENCE BAND Trigger EVENT

DETECT GAIT EVENTS

PROCESSING UNIT STIMULUS ISOLATOR

CONTROL POLICIES

Z coordinate

PI Time

Nano Tera Meeting ‐ Spine Repair

Height

N. WENGER

Freq

+ 19

STIMULATION ADAPTATION

Next steps

selective stimulation of the roots

20µm

Stimulator gen 2 with integrated potential recording and impedance Miniaturisation

Spatio-temporal development

5/29/2015

Nano Tera Meeting ‐ Spine Repair

20

Communications

• 5 Journal publications (+ 2 submitted) – IEEE Trans. on Circuits and Systems II, 2015 in press – Science, 2015 347(6218): 159‐163 – Science Translational Medicine, 2014 Sep 24;6(255):255ra133 – Journal of Neuroscience 2013 Dec 4;33(49):19326‐40

• > 15 international conference contributions – Materials Research Society – Society for Neuroscience

• 3 patent applications (pending) 5/29/2015

Nano Tera Meeting ‐ Spine Repair

21

Thanks from the SpineRepair Team Questions & Answers

5/29/2015

22 Nano Tera Meeting ‐ Spine Repair