School of Engineering Lab Activity Report 2009 by Breadfruit

STI Lab Report 2009 Activity report

School of Engineering

This document focuses on the individual laboratories and centers of the EPFL School of Engineering (STI), providing insight into their positioning, area of research, significant publications and funding.

CONTENTS Institute of Electrical Engineering

Institute of Mechanical Engineering

Institute of Materials Science and Engineering

Institute of Microengineering

127

Interfaculty Institute of Bioengineering

181

Centers

221

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Institute of Electrical Engineering

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Embedded Systems Laboratory David Atienza Alonso, Tenure Track Assistant Professor Prof. David Atienza received his MSc and PhD degrees in Computer Science and Engineering from Complutense University of Madrid (UCM), Spain, and Inter-University Micro-Electronics Center (IMEC), Belgium, in 2001 and 2005. Currently he is Professor and Director of the Embedded Systems Laboratory (ESL) at EPFL, and Adjunct Professor at the Computer Engineering Dept of UCM. Also, he is Scientific Counselor of long-time research of IMEC, Netherlands. His research interests focus on design methodologies for high-performance embedded systems, including thermal-aware design for 2D/3D Multi-Processor Systems-on-Chip (MPSoCs), wireless sensor networks and novel nano-architectures for logic and memories. In these fields, he is co-author of more than 100 publications in prestigious journals and conferences. Prof. Atienza is Associate Editor of IEEE Transactions on CAD of Electronic Systems, IEEE Letters of Embedded Systems and Elsevier Integration. He is an elected member of the Executive Committee of the IEEE Council of Electronic Design Automation (CEDA) since 2008. In 2009, he was named IEEE Young Gold Member Coordinator on EDA. At EPFL since 01/10/2008. Keywords: Embedded systems design, multi-processor system-on-chip (MPSoC) optimization, thermal modeling, software mapping. http://esl.epfl.ch/

2007-2009 Significant Publications D. Atienza, P. G. Del Valle, G. Paci, F. Poletti, L. Benini, G. De Micheli, R. Hermida, “HW-SW Emulation Framework for Temperature-Aware Design in MPSoCs”, ACM Transactions on Design Automation for Embedded Systems (TODAES) (31/08/2007), 1084-4309 D. Atienza, F. Angiolini, S. Murali, A. Pullini, L. Benini, G. De Micheli, “Network-On-Chip Design and Synthesis Outlook”, Integration - The VLSI journal (Integration) (31/03/2008), 340-359 C. Baloukas, J. L. Risco-Martin, D. Atienza, C. Poucet, J. I. Hidalgo, F. Catthoor, “Optimization Methodology of Dynamic Data Structures based on Genetic Algorithms for Multimedia Embedded Systems”, Journal of Systems and Software (JSS) (30/11/2008), 590-602 M. H. Ben Jamaa, K. E. Moselund, D. Atienza, D. Bouvet, A. M. Ionescu, Y. Leblebici, G. De Micheli, “Variability-Aware Design of Multi-Level Logic Decoders for Nanoscale Crossbar Memories”, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems (T-CAD) (30/11/2008), 2053-2067 N. Boichat, N. Khaled, F. Rincon, D. Atienza, “Wavelet-Based ECG Delineation on a Wearable Embedded Sensor Platfor”, Body Sensor Networks (BSN 2009) (03/06/2009), 256-261

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Research Interests The Embedded Systems Laboratory (ESL) is part of the Institute of Electrical Engineering at EPFL, and focuses on the definition of reliability-aware design, optimization methodologies and system-level exploration tools for high-performance embedded systems, wireless sensor networks (WSNs) and nano-scale MultiProcessor System-on-Chip (MPSoC) architectures. These goals involve the development of novel thermal and reliability exploration frameworks and HW/SW management approaches for 2D and 3D MPSoCs and embedded systems. Also, the laboratory has a research record on system-level design and energy management approaches at the hardware and operating system level of body-area WSNs. Finally, the most recent line of research at ESL is the development of fault-tolerant circuits and design methodologies for emerging nano-scale electronics made from carbon nanotubes, graphene and silicon nanowires. In all the ESL research activities, it is very important the industrial link between the different proposed research solutions and the future adoption by the semiconductor industry and multimedia embedded systems manufacturers.

Current Group 2 Scientific Collaborators 3 PhD Students 1 Administrative Assistant 1 Technician 2 PhD Students (external) 3 Master Students 2 Internship Students 2 Student Grant-holders 1 Scientific Adviser

2007-2009 External Grants received at the EPFL Teaching Activities Swiss NSF Research Grant - Dynamically Adaptive Architectures for The teaching activies of ESL refer to embedded systems design and Nomadic Embedded Systems 2009-2011 CHF 301’840 MPSoC optimization, especially with a practical industrial application and professional design perspective. All the teaching activities of ESL Sun Microsystems - Academic Donation Program at the undergraduate level are performed with the Section of Electrical 2008-2009 CHF 21’740 Engineering (SEL) at EPFL. At the Bachelor Level, ESL will teach Circuits and Systems I and II since the academic course 2009-2010. Also, Nano-Tera.ch Research Programme - NTF Project: CMOSAIC ESL offers Semester and M.Sc. student projects since October 2008. For 2009-2012 CHF 374’790 the academic year of 2009-2010, two M.Sc. student and two Semester project students will be supervised at ESL. European Commission - HIPEAC-II Mobility Grants 2008-2009 CHF 30’386 Finally, ESL is part of the Doctoral Programs of Electrical Engineering (EDEE) and Microsystems and Microelectronics (EDMI) at STI-EPFL. Within these programs, ESL currently directs two PhD students (1 at Collaborations & Networks EDEE and 1 at EDMI), and teaches the course "Co-design and Synthesis • In thermal/reliability modeling and management for 2D/3D MPSoCs, of Multi-Processor System-on-Chip Architectures on Reconfigurable ESL cooperates with IBM Zurich (CH), ETHZ (CH), IBM Yorktown Hardware". Heights (US), Sun Microsystems (US), UCSD (US), Stanford Univ. (US), Complutense Univ. of Madrid (ES), Univ. of Bologna (IT), Democritus Univ. of Thrace (GR), Technical Univ. of Athens (GR) and IMEC (BE). • In system-level design and energy management for wireless sensor networks, ESL is working with the Holst Centre (NL), Politecnico di Milano (IT), Univ. of Carlos III (ES), Philips-NXP (NL) and Associated Compiler Experts - ACE (NL). Also, ESL is part of the European Network of Excellence on High Performance and Embedded Architecture and Compilation (HIPEAC-II). • In the area of logic circuit design made from carbon nanotubes, ESL cooperates with Stanford University (US).

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L'IDIAP Laboratory Herve Bourlard, Full Professor Director of Idiap Research Institute Hervé Bourlard received the Electrical and Computer Science Engineering degree and the Ph.D. degree in Applied Sciences both from “Faculté Polytechnique de Mons”, Mons, Belgium. After having been a member of the Scientific Staff at the Philips Research Laboratory of Brussels and an R&D Manager at L&H SpeechProducts, he is now Director of the Idiap Research Institute (www.idiap.ch), Full Professor at the Swiss Federal Institute of Technology at Lausanne (EPFL), and Director of a National Centre of Competence in Research in “Interactive Multimodal Information Management” (IM2, www.im2.ch). Having spent (since 1988) several long-term and short-term visits (initially as a Guest Scientist) at the International Computer Science Institute (ICSI, www.icsi.berkeley.edu) in Berkeley, CA, he is now a member of the ICSI Board of Trustees. H. Bourlard is the author/coauthor/editor of 4 books and over 250 reviewed papers (including one IEEE paper award) and book chapters. He is an IEEE Fellow “for contributions in the fields of statistical speech recognition and neural networks”. He is (or has been) a member of the program/scientific committees of numerous international conferences (e.g., General Chairman of IEEE Workshop on Neural Networks for Signal Processing 2002, Co-Technical Chairman of ICASSP 2002, General Chairman of Interspeech 2003) and on the editorial board of several journals (e.g., past co-Editor-in-Chief of “Speech Communication”).

Scientific activities IM2 National Centre of Competence in Research (interactive and multimodal management of information systems) since 2001 Participation in 37 research programmes Project management in 5 consortiums Participation in the economic development strategy of the Canton of Valais through The Ark programme and in particular the IdeArk company (cf. pages 18-19) 133 scientific publications Organisation of a number of international conferences 2007-2009 Significant Publications Deepu Vijayasenan, Fabio Valente and Hervé Bourlard, “An Information Theoretic Approach to Speaker Diarization of Meeting Data”, IEEE Transactions on Audio Speech and Language Processing (2009), 17(7):1382-1393 Sree Hari Krishnan Parthasarathi, Mathew Magimai.-Doss, Hervé Bourlard and Daniel Gatica-Perez, “Investigating Privacy-Sensitive Features for Speech Detection in Multiparty Conversations”, IDIAP Research Report (2009), Alessandro Vinciarelli, Maja Pantic and Hervé Bourlard, “Social Signal Processing: Survey of an Emerging Domain”, Image and Vision Computing (2009), Hamed Ketabdar and Hervé Bourlard, “Hierarchical Integration of Phonetic and Lexical Knowledge in Phone Posterior Estimation”, ICASSP’08 (2008), T. Dutoit, L. Couvreur and Hervé Bourlard, “How does a dictation machine recognize speech ?”, Applied Signal Processing - A MATLAB approach (2008), Collaborations & Networks See http://www.idiap.ch; involvement in numerous EU and US collaborative projects as well as exchange programs. Small enterprises, e.g., IrisGuard, Covadis, Sensometrics, and the GTPB’s spin-off “PatternLab”.

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Over the last 20 years, Hervé Bourlard has initiated and coordinated numerous large international research Current Group projects, as well as multiple collaborative projects with industries. He is an appointed expert for the European 82 Scientists Commission and, from 2002 to 2007, was also part of the European Information Society Technology Advisory Group (ISTAG). Research Interests Signal processing, statistical pattern classification, multi-channel processing, artificial neural networks, and applied mathematics, with applications to speech and natural language modeling, speech and speaker recognition, computer vision, and multimodal processing. Through its research activities, Idiap pursues its main objective to conduct fundamental research projects at the highest level in its preferred areas, thus taking its place among the best on a national, European and global scale. Idiap benefits from a wide network of partners internationally and works actively with large universities, public and private research centers, etc. Keywords: Perceptual and cognitive systems, Social / human behavior, Information interfaces and presentation, Biometric Person Recognition, Machine learning. http://idiap.epfl.ch/

Teaching Activities IDIAP is teaching 6 courses at EPFL: - Speech signal processing (master level) - Artificial cognitive systems (doctoral level) - Biometric user recognition (doctoral level) - Human language technology (doctoral level) - Speech signal processing (doctoral level) - Statistical sequence processing (doctoral level) ‘Biometric Identity Verification’ EPFL Continuing Education School and EPFL Center for Interdisciplinary Studies in Information Security, Lecturer and Organizer: Dr. A. Drygajlo, April 30 - May 3, 2007.

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Quantum Architecture Lab Edoardo Charbon, Adjunct Professor Full Professor at TU Delft Edoardo Charbon received the Diploma from ETH Zurich in 1988, the M.S. degree from UCSD in 1991, and the Ph.D. degree from UCBerkeley in 1995, all in Electrical Engineering and EECS. From 1995 to 2000, he was with Cadence Design Systems, where he was the architect of the company’s information-hiding physical design tools for intellectual property protection. In 2000, he joined Canesta Inc. as its Chief Architect, leading the development of wireless 3-D CMOS image sensors. Since November 2002, he has been a member of the Faculty of EPFL in Lausanne, Switzerland. In Fall 2008 he has joined the Faculty of TU Delft, as full professor and chair in VLSI design. Dr. Charbon has consulted for numerous organizations, including Texas Instruments, Hewlett-Packard, and the Carlyle Group. He has published over 120 articles in technical journals and conference proceedings and two books, and he holds ten patents. Dr. Charbon has served as Guest Editor of the TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS and SYSTEMS and the JOURNAL OF SOLID STATE CIRCUITS and as Chair of technical committees in ESSCIRC, ICECS, ISLPED, and VLSI-SOC. At EPFL since November 2002 Keywords: SPAD, VLSI, Bioimaging, Image Sensors. http://aqua.epfl.ch

2007-2009 Significant Publications D. L. Boiko, N. J. Gunther, N. Brauer, M. Sergio, C. Niclass, G. B. Beretta, E. Charbon, “A Quantum Imager for Intensity Correlated Photons”, New Journal of Physics (November 2008), Vol. 10, N. 11 D. E. Schwartz, E. Charbon, K. Shepard, “A Single-Photon Avalanche Diode Array for Fluorescence Lifetime Imaging Microscopy”, IEEE Journal of Solid-State Circuits (November 2008), Vol. 43, N. 11, pp. 2546-2557 U. Lehmann, M. Sergio, S. Pietrocola, E. Dupont, C. Niclass, M.A.M. Gijs, and E. Charbon, “Microparticle Photometry in a CMOS Microsystem Combining Magnetic Actuation and in Situ Optical Detection”, IEEE Sensors & Actuators B (Chemical) (May 2008), pp. 411-417 E. Charbon, “Towards Large Scale CMOS Single-Photon Detector Arrays for Lab-on-Chip Applications”, J. Phys. D: Applied Physics (May 2008), Vol. 41, N. 9 B. R. Rae, C. Griffin, J. McKendry, J. M. Girkin, H. X. Zhang, E. Gu, D. Renshaw, E. Charbon, M.D. Dawson, R.K. Henderson, “CMOS Driven Micro-pixel LEDs Integrated with Single Photon Avalanche Diodes for Time Resolved Fluorescence Measurements”, J. Phys. D: Applied Physics (May 2008), Vol. 41, N. 9 C. Niclass, M. Gersbach, R.K. Henderson, L. Grant, E. Charbon, “A Single Photon Avalanche Diode Implemented in 130nm CMOS Technology”, IEEE Journal of Selected Topics in Quantum Electronics (July/Aug. 2007), Vol. 13, N. 4, pp. 863-869 C. Niclass, C. Favi, T. Kluter, F. Monnier, E. Charbon, “Single-Photon Synchronous Detection”, IEEE Journal of Solid-State Circuits (July 2009), Vol. 44, N. 7 E. Gregoriev, E. Charbon, et al., “Silicon Photomultipliers and their Bio-medical Applications”, Nuclear Instruments & Methods in Physics Research A (January 2007), Vol. 571 N. 1+2, pp. 130-133 M. Gersbach, D. L. Boiko, C. Niclass, C. Petersen, E. Charbon, “Fast Fluorescence Dynamics in Non-ratiometric Calcium Indicators”, Optics Letters (February 2009), Vol. 34, N. 3, pp. 362-364 C. Niclass, C. Favi, T. Kluter, M. Gersbach, E. Charbon, “A 128×128 Single-Photon Imager with on-Chip Column-Level 10b Time-to-Digital Converter Array Capable of 97ps Resolution”, IEEE Journal of Solid-State Circuits (December 2008), Vol. 43, N. 12, pp. 2977-2989 M. Gersbach, J. Richardson, C. Niclass, L. Grant, R. Henderson, E. Charbon, “Low-Noise SinglePhoton Detectors in 130-nm CMOS Technology”, Solid-State Electronics (August 2009),

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Research Interests High-performance imaging and bioimaging, quantum integrated circuits, design automation algorithms, and ultra low-power wireless embedded systems.

2007-2009 Awards Thirty Best Papers, J. Phys. D: Applied Physics 2008-12-12 for the paper “Towards Large Scale CMOS Single-Photon Detector Arrays for Lab-on-Chip Applications” 2007-2009 Patents E. Charbon et al., “Transducer for reading information stored on an optical record carrier, single photon detector based storage system and method for reading data from an optical record carrier”: 7,501,528 E. Charbon et al., “Integrated imager circuit comprising a monolithic array of single photon avalanche diodes”: 7,262,402 E. Charbon, “Electromagnetic wave detection arrangement with capacitive feedback”: 7,173,230 Collaborations & Networks Columbia University, U.C. Berkeley, U.C. San Diego, Stanford University, The University of Pavia, The University of Edinburgh, FBK Trento, TU Delft, ETH Zurich, CERN Geneva, European Space Agency Teaching Activities Solid-State Imaging: Architectures and Techniques

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Integrated Systems Laboratory Giovanni De Micheli, Full Professor (STI/IC) Director of the Institute of Electrical Engineering, Director of the Integrated Systems Center Giovanni De Micheli is Professor and Director of the Institute of Electrical Engineering and of the Integrated Systems Center at EPF Lausanne, Switzerland. He also chairs the Scientific Committee of CSEM, Neuchatel, Switzerland. Previously, he was Professor of Electrical Engineering at Stanford University. He received the 1987 D. Pederson Award for the best paper on the IEEE Transactions on CAD/ICAS, two Best Paper Awards at the Design Automation Conference, in 1983 and in 1993, and a Best Paper Award at the DATE Conference in 2005. Prof. De Micheli’s H-index is 56, according to Google scholar. Some of his books, such as Design and Optimization of Digital Circuits, are used worldwide for teaching and research. He is the founder and leader on the nano-tera.ch program, a federal Swiss grant providing an aggregate of 120MCHF to Swiss researchers in the area of distributed embedded systems and related circuit/sensor technologies for four yeras. Keywords: VLSI, nanoelectronics, CAD, EDA, embedded systems, bioinformatics. http://lsi.epfl.ch

2007-2009 Significant Publications M. H. Ben Jamaa, K. E. Moselund, D. Atienza, D. Bouvet, A. Ionescu, Y. Leblebici, G. De Micheli, “Variability-Aware Design of Multilevel Logic Decoders for Nanoscale Crossbar Memories”, IEEE Transactions on CAD (November 2008), 2053-2067 G. De Micheli, “An Outlook on Design Technologies for Future Integrated Systems”, IEEE Transactions on CAD (June 2009), 777-790 S. Murali, L. Benini, G. De Micheli, “An Application-Specific Design Methodology for On-Chip Crossbar Generation”, IEEE Transactions on CAD (July 2007), 1283-1296 S. Murali, P. Meloni, D. Atienza, S. Carta, L. Benini, G. De Micheli, L. Raffo, “Synthesis of Predictable Networks on Chip Based Interconnect Architectures for Chip Multiprocessors”, IEEE Transactions on VLSI (August 2007), 869-880 S. Yoon, J. Ebert, E.Y. Chung, G. De Micheli, R. Altman , “Clustering Protein Environments for Function Prediction: Finding PROSITE motifs in 3D”, BMC Bioinformatics (22/5/2007), 8:S10 G. De Micheli, Y.Leblebici, M. Gjis, J. Voeroes, “NanoSystem Design and Technology”, Springer (2009), Book A. Garg, A. Di Cara, I. Xenarios, L. Mendoza, G. De Micheli, “Synchronous versus asynchronous modeling of gene regulatory networks”, Bioinformatics (2008), 1917-1925 S. Yoon, L. Benini, G. De Micheli , “Co_clustering: A Versatile Tool for Data Analysis in Biomedical Informatics ”, IEEE Transactions on Information Technology in Biomedicine (2007), 493-494

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Research Interests Giovanni De Micheli’s research interests cover several aspects of design technologies for integrated circuits and systems. Examples include, but are not limited to, synthesis technology (i.e., algorithms to map high-level specifications into detailed circuit descriptions), network on chip technology (i.e. means to provide reliable and structured interconnect on chip), hardware/software co-design (i.e., the concurrent design and optimization of hardware and software portions of circuits), 3-dimensional circuit integration techniques (from technological issues to sofware and communication aspects) low-power/energy design design (via circuit, logic and functional optimization as well as power management techniques), and the design of systems using heterogeneous platforms with electrical, micromechanical and biological components (such as biosensons for diagnosis and pollution control).

Current Group 1 Adjunct Professor 1 Administrative Assistant 2 Senior Scientists 5 Postdoctoral Fellows 10 PhD Students 4 PhD Student externals 1 Technician

Collaborations & Networks He has been serving IEEE in several capacities, namely: Division 1 Director (2008-9), co-founder and President Elect of the IEEE Council on EDA (2005-7), President of the IEEE CAS Society (2003), Editor in Chief of the IEEE Transactions on CAD/ICAS (1987-2001). He was Program Chair of the pHealth and VLSI SOC conferences in 2006. He was the Program and General Chair of the Design Automation Conference (DAC) in 1996-1997 and 2000 respectively. He was the Program and General Chair of the International Conference on Computer Design (ICCD) in 1988 and 1989 respectively. He is a founding member of the ALaRI institute at Universita’ della Svizzera Italiana (USI), in Lugano, Switzerland, where he is currently scientific counselor. 2007-2009 External Grants received at the EPFL SNSF 2006-2009 SER - Nano-tera.ch 2008-2011 ETHrat CCMX/MMNS 2007-2009

Teaching Activities CHF 218’800 Prof. De Micheli teaches Desgin technologies for Integrated Circuits (at the Master level). CHF 60’000’000 CHF 4’170’000

2007-2009 Patents Srinivasan MURALI Luca BENINI Giovanni DE MICHELI, “Method to design Network-on-Chip (NoC)-based communication systems”: filed not yet granted Salvatore CARTA Paolo MELONI Giovanni DE MICHELI Luigi RAFFO , “Methods for Hardware Reduction and Overall Performance Improvement in Communication Systems”: filed - not yet granted Federico ANGIOLINI David ATIENZA ALONSO Giovanni DE MICHELI, “Method to manage the load of peripheral elements within a multicore system ”: filed - not yet granted

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Radio Frequency Integrated Circuits Catherine Dehollain, Senior Scientist Catherine Dehollain received the M.Sc. degree in electrical engineering in 1982 and the Ph.D. degree in 1995, both from the Swiss Federal Institute of Technology in Lausanne (EPFL). From 1982 to 1984, she was a Research Assistant at the Electronics Laboratories (LEG) of EPFL where she designed switched capacitor filters and studied MOS transistor modeling. In 1984, she joined the Motorola European Center for Research and Development, in Geneva, Switzerland, where she designed integrated circuits applied to telecommunications. In 1990, she returned to EPFL as a Senior Assistant at the Chaire des Circuits et Systemes (CIRC) where she worked on impedance broadband matching. Since 1995, she has been responsible at EPFL for the radio frequency integrated circuits group (RF ICs group). She has been the technical project manager of European projects, CTI projects, and Swiss National Science Foundation projects dedicated to RF wireless micro-power sensor networks and mobile phones. Since 1998, she has been a Lecturer at EPFL in the area of radio frequency circuits, electric filters and CAD tools. Since 2006, she is “Maitre d’Enseignement et de Recherche” (MER) at EPFL. Her technical interests include low-power analog circuits, biomedical remotely powered sensors, and electric filters. She is an author or coauthor of four scientific books and 50 scientific publications. Keywords: Radio Frequency Wireless Communication Systems, Radio Frequency Identification Systems (RFID), Remotely Powered Electronic Circuits , Electronic Circuits dedicated to Biomedical Applications, Micro Power Analog Integrated Circuits, Electrical Analog Filters, Broadband Impedance Matching Circuits. under construction (future address: rfic.epfl.ch)

2007-2009 Significant Publications N. Pillin, N. Joehl, C. Dehollain, M. Declercq, “Wireless Voltage Regulation for Passive Transponders using an IF to Communicate”, IEEE Transactions on Circuits and Systems I (to be published), 12 pages F. Xavier Moncunill-Geniz, P. Palà-Schönwälder, C. Dehollain, N. Joehl, M. Declercq, An 11Mb/s 2.3 mW Synchronous Superregenerative Receiver at 2.4GHz”, IEEE Transactions on Microwave Theory and Techniques, Vol. 55, n° 6, Part 2 (June 2007), pp. 1355-1362 K.M. Silay, C. Dehollain and M. Declercq, “Numerical Analysis of Temperature Elevation in the Head due to Power Dissipation in a Cortical Implant”, IEEE EMBC Conf., Vancouver, Canada (20th-24th Aug. 2008), pp. 951-956 K.M. Silay, C. Dehollain and M. Declercq, “Orthogonally Oriented Coils for Minimization of Cross-Coupling in Cortical Implants”, IEEE BIOCAS Conf., Baltimore., USA (20th-22nd Nov. 2008), pp. 109-112 J. P. Curty, M. Declercq, C. Dehollain and N. Joehl, “Design and Optimization of passive UHF RFID Systems”, Springer (2007), ISBN: 0-387-35274-0 M. Green, M. Pisani, C. Dehollain, “Design methodology for CMOS Distributed Amplifiers”, IEEE International Symposium on Circuits and Systems, Seattle, USA (18th - 21th May 2008), pp. 728-731 N. Pillin, N. Joehl, C. Dehollain, M. Declercq, “High Data Rate RFID Tag / Reader Architecture using Wireless Voltage Regulation”, IEEE International Conf. on RFID 2008, Las Vegas, USA (16th and 17th April 2008), pp. 141-149. P.E. Thoppay, C. Dehollain, M.J. Declercq, “A 7.5 mA, 500 MHz UWB receiver based on Super-regenerative principle”, 34th European Solid-State Circuits Conf., Edinburgh, UK (15th - 19th Sept. 2008), pp. 382-385

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Research Interests Radio Frequency Wireless Communication Systems Radio Frequency Identification Systems (RFID) Remotely Powered Electronic Circuits (e.g. magnetic or electro-magnetic, electro-acoustic coupling) Electronic Circuits dedicated to Biomedical Applications Micro Power Analog Integrated Circuits Electrical Analog Filters Broadband Impedance Matching Circuits

Current Group 6 PhD Students 1 Senior Scientist 1 PhD Student (external)

2007-2009 External Grants received at the EPFL IST European project Minami. Dr. Pierre Nicole (Thales, France) in the SNF: NEURO-IC and NEURO-IC II: implanted electronic system with joined project on Mems filters. IMASONIC (France), INSERM (France) radio link to record neural activity of the brain NEURO-IC: from Jan. and HEIG-VD (CH) in the IST European project Ultrasponder. 2007 to Dec. 2008, NEURO-IC II: from Jan. 2009 to Dec. 2010. (total) CHF 248’068 Teaching Activities NCCR MICS SNF on UWB Communication From Nov. 2006 up to Oct. “HF and VHF Circuits and Techniques I and II” to the 4th year EPFL 2009 CHF 271’098 Electrical Students and to the Nano-Tech (MNIS) Students."Outils informatiques" to the 3rd year EPFL Electrical Students."Electrical filters" NANO-TERA SNF: SiMOS, smart implant for orthopedic surgery in the to the 3rd year EPFL Electrical Students. case of knee prosthesis. From Sept 2009 to Aug. 2013 CHF 270’000 European STREP Project ULTRASPONDER: micropower integrated deeply implant. From Sept. 2008 to Aug. 2011 CHF 658’260 European Marie-Curie Project FLEXSmell: Gas sensors on Flexible substrate for Wireless Applications. From Jan. 2010 to Dec. 2013 CHF 397’222 Contract with Thales (France) on MEMs Filters. From 2007 up to 2010 CHF 123’000 Contract with Oridao Company (France): secured remotely powered RFID tag. From 2008 to 2009 CHF 51’200 Collaborations & Networks Dr. Dominique Morche (CEA-LETI - France) and Prof. Franco Maloberti (Univ. of Pavia- Italy) on ultra-low power A/D converters Prof. Francesc Xavier Moncunill Geniz (Univ. Politècnica de Catalunya, Barcelona, Spain) on spread-spectrum super-regenerative receivers Prof. Jean-Yves le Boudec (LCA, EPFL) on Impulse Radio UWB Communication. Prof. Yusuf Leblebici (LSM, EPFL) on RF link system to record brain activity . Prof. Anja Skrivervik (LEMA, EPFL) on miniature antennas. Professor Kamiar Aminian (LMAM, EPFL) on biomedical applications. Dr. Pascal Ancey (STM, France) and Mr. Frank Henkel (IMST GmbH, Germany) respectively in the IST European projects Minami and Ultrasponder. Dr. Christian Piguet (CSEM, Neuchatel) on low-power DSP processor. Prof. Michael Green (Univ. of California - Irvine, USA) on RF broadband integrated circuits. Dr. Jacek Barborowski (CSEM) and Dr. Bertrand Gomez (CEA, LETI) in the

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Group Ebrahimi Touradj Ebrahimi, Adjunct Professor Prof. Ebrahimi is the head of the Swiss delegation to MPEG, JPEG and SC29, and acts as the Chairman of Advisory Group on Management in SC29, overseeing both MPEG and JPEG standards. He is a co-founder of Genista SA, a high-tech start-up company in the field of multimedia quality metrics, which was acquired by Symmetricom in 2007. In 2002, he founded Emitall SA, a start-up company active in media technologies. In 2005, he founded EMITALL Surveillance SA, a start-up active in the field of privacy protection in video surveillance. In 2003 he co-founded the Digital Media Project (DMP), a not-for-profit association in media security, where he serves as a board member. He is or has been associate Editor with various IEEE, SPIE, and EURASIP journals, such as IEEE Signal Processing Magazine, IEEE Trans. on Image Processing, IEEE Trans. on Multimedia, EURASIP Image Communication Journal, EURASIP Journal of Applied Signal Processing, SPIE Optical Engineering Magazine. Prof. Ebrahimi is a member of Scientific Advisory Board of various start-up and established companies in the general field of Information Technology. He has served as Scientific Expert and Evaluator for Research Funding Agencies such as those of European Commission, Belgian Federal Funding Agency, Wallonnie Region Research Funding Agency, Greek Ministry of Development, Austrian National Foundation for Scientific Research, French ANR Research Agency, Portuguese Science Foundation, as well as a number of Venture Capital Companies active in the field of Information Technologies and Communication Systems. Prof. Ebrahimi has more than 200 publications in his active, including 50 journal papers, 130 peer reviewed conference papers, several book chapters, and 4 books. Keywords: Multimedia Signal Processing, Image and Video Compression, Image and Video Processing, Image and Video Analysis, Brain-Computer Interface, Multimedia Security, Video Surveillance, Media Technologies. http://mmspg.epfl.ch/

2007-2009 Significant Publications P. Schelkens, A. Skodras and T. Ebrahimi, “The JPEG 2000 Suite”, Wiley (2009-07-01), Book Elisa Drelie and Touradj Ebrahimi, “On Evaluating Video Object Segmentation Quality: A Perceptually Driven Objective Metric”, IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING (2009-04-01), Vol. 3, Nr. 2, pp. 319-335 F. Pereira, L. Torres, C. Guillemot, T. Ebrahimi, R. Leonardi and S. Klomp, “Distributed Video Coding: Selecting the most promising application scenarios”, Signal Processing: Image Communication (2008-11-01), Vol. 23, pp. 339-352 Frederic Dufaux and Touradj Ebrahimi, “Scrambling for Privacy Protection in Video Surveillance Systems”, IEEE Trans. on Circuits and Systems for Video Technology (2008-10-31), Vol. 18, No. 8, pp. 1168-1174 M. Ouaret, F. Dufaux and T. Ebrahimi, “Iterative Multiview Side Information for Enhanced Reconstruction in Distributed Video Coding”, EURASIP Journal on Image and Video Processing (2008-07-01), U. Hoffmann, J.-M. Vesin, T. Ebrahimi and K. Diserens, “An efficient P300-based brain-computer interface for disabled subjects”, Journal of Neuroscience Methods (2008-03-01), Vol. 167, Nr. 1, pp. 115-125 C. Guillemot, F. Pereira, L. Torres, T. Ebrahimi, R. Leonardi and J. Ostermann, “Distributed Monoview and Multiview Video Coding”, IEEE Signal Processing Magazine (2007-10-30), Vol. 24, Nr. 5, pp. 67-76 M. Corsini, E. Drelie Gelasca, T. Ebrahimi and M. Barni, “Watermarked 3D Mesh Quality Assessment”, IEEE Transactions on Multimedia (2007-09-01), Vol. 9, Nr. 2, pp. 247-256 2007-2009 Awards Certificate of outstanding contribution, ISO 2009-04-30 For contributions to JPSearch standard Certificate of outstanding contribution, ISO 2009-04-30 For contributions to JPEG XR image compression standard 2007-2009 Patents Touradj Ebrahimi and Frederic Dufaux, “Scrambling for Anonymous Visual Communication”: PCT/IB2006/002083. Touradj Ebrahimi and Frederic Dufaux, “Region-based Transform Domain Video Scrambling”: PCT/IB06/03100. Touradj Ebrahimi and Frederic Dufaux, “Efficient Scrambling Of Regions Of Interest In An Image Or Video To Preserve Privacy”: PCT/IB05/03863. Touradj Ebrahimi and Frederic Dufaux, “Smart Video Surveillance System Ensuring Privacy”: PCT/IB05/02989

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Research Interests Multimedia coding: still image, video and 3D compression. Multimodal processing, analysis and interpretation: change detection, feature point extraction and tracking, object segmentation and tracking, compressed domain processing, metrics for quality of experience, and brain computer interface. Media security: copyright and privacy protection, conditional access and integrity verification.

2007-2009 External Grants received at the EPFL Swiss National Foundation for Scientific Research 2008-2011

CHF 248’412

Swiss National Foundation for Scientific Research 2008-2009

CHF 160’000

Swiss National Foundation for Scientific Research 2007-2009

CHF 170’768

KTI/CTI 2009-2010

CHF 250’660

KTI/CTI 2007-2008

CHF 385’016

European Space Agency 2008-2009

CHF 39’856

European Commission 2006-2008

CHF 483’600

European Commission 2007-2009

CHF 854’129

European Commission 2008-2011 COST 2009-2010

Current Group 4 PhD Students 2 Scientific Collaborators 3 Engineers 1 Administrative Assistant 1 Apprentice Technician 2 Postdoctoral Fellows 2 Internship Students

Teaching Activities CHF 1’319’400 Advanced image processing and analysis Bio-inspired processing of cognitive signals CHF 194’653 Image and Video Processing Media Security

Collaborations & Networks - European Networks of Excellence: K-space, Visnet, Petamedia, COST IC0604 - Motion Picture Experts Group (MPEG) - Joint Photographic Experts Group (JPEG) - Digital Media Project (DMP) - NCCR on Interactive Multimodal Information Management (IM2) - IEEE IMDSP Technical Committee, IEEE MMDSP Technical Committee - Montreux Jazz Festival Digital Archive Project

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Group Enz Christian Enz, Adjunct Professor Christian Enz, PhD, Swiss Federal Institute of Technology (EPFL), 1989. Joined the Swiss Center for Electronics and Microtechnology (CSEM) in Neuchâtel, Switzerland, in 1999, where he is currently VP heading the Microelectronics Division. He is also Adjunct Professor at EPFL, where he is lecturing and supervising undergraduate and graduate students in the field of analog and RF IC design. Prior to joining the CSEM, he was Principal Senior Engineer at Conexant (formerly Rockwell Semiconductor Systems), Newport Beach, CA, where he was responsible for the modeling and characterization of MOS transistors for RF applications. His technical interests and expertise are in the field of ultralow-power analog and RF IC design, wireless sensor networks and semiconductor device modeling. Together with E. Vittoz and F. Krummenacher he is the developper of the EKV MOS transistor model and the author of the book “ChargeBased MOS Transistor Modeling - The EKV Model for Low-Power and RF IC Design” (Wiley, 2006). He is the author and co-author of more than 140 scientific papers and has contributed to numerous conference presentations and advanced engineering courses. Keywords: analog, RF CMOS, low-power, noise. http://lsi.epfl.ch/

2007-2009 Significant Publications J. Chabloz, D. Ruffieux, A. Vouilloz, P. Tortori, F. Pengg, C. Muller, and C. Enz, “Frequency Synthesis for a Low-Power 2.4 GHz Receiver Using a BAW Oscillator and a Relaxation Oscillator”, Proc. of the European Solid-State Circ. Conf. (ESSCIRC) (Sept. 2007), pp. 492-495 A. S. Roy and C. C. Enz, “Analytical Noise Modeling in MOSFET”, Proc. of the Int. Conf. on Noise and Fluctuations (ICNF) (Sept. 2007), pp. 57-62 (Invited) A. S. Roy, C. C. Enz, and J. M. Sallese, “Source–Drain Partitioning in MOSFET”, IEEE Trans. Electron Devices, vol. 54, no. 6 (June 2007), pp. 1384-1393 D. Ruffieux, J. Chabloz, M. Contaldo, C. Muller, F. X. Pengg, P. Tortori, A. Vouilloz, P. Volet, and C. Enz, “A Narrowband Multi-Channel 2.4 GHz MEMS-Based Transceiver”, IEEE Journal of Solid-State Circuits, vol. 44, no. 1 (Jan. 2009), pp. 228-239 C. Enz, J. Chabloz, J. Baborowski, C. Müller, and D. Ruffieux, “Building Blocks for an Ultra Low-Power MEMS-based Radio”, IEEE Int. Workshop on Radio-Frequency Integration Technology (Dec. 2007), pp. 158-167 A. S. Roy, C. C. Enz, T. C. Lim, and F. Danneville, “Impact of Lateral Asymmetry of MOSFETs on the Gate and Drain Noise Correlation”, IEEE Trans. Electron Devices, vol. 55, no. 8 (Aug. 2008), pp. 2268-2272 C. C. Enz, J. Baborowski, J. Chabloz, M. Kucera, C. Muller, D. Ruffieux, and N. Scolari, “Ultra Low-Power MEMS-based Radio for Wireless Sensor Networks”, Proc. of the European Conference on Circuit Theory and Design (ECCTD) (Aug. 2007), pp. 320-331 (Invited Keynote) A. S. Roy, C. C. Enz, and J. M. Sallese, “Noise Modeling in Lateral Nonuniform MOSFET”, IEEE Trans. Electron Devices, vol. 54, no. 8 (Aug. 2007), pp. 1994-2001

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Research Interests Current Group 1) Semiconductor device modeling. Following the development of the EPFL-EKV MOS transistor model (PhD of M. Bucher), we have 4 PhD Students investigated some fundamental issues on compact noise modeling of nanoscale bulk and double-gate MOS transistors (PhD of A.S. Roy). Another topic of interest is the development of a new compact model of organic devices. 2) Analog and RF IC Design. We are exploring how the analog-to-digital converter (ADC), which remains one of the most power hungry block in a digital RF receiver, can be replaced by a phase-ADC taking advantage of a direct quantization of the phase for constant envelope modulations (PhD candidate B. Banerjee). After having investigated the use of high-Q bulk acoustic wave (BAW) resonators in the receiver part of an RF transceiver (PhD of J. Chabloz), we now are looking at how BAW resonators can be used in the transmitter and particularly in the power amplifier (PhD candidate M. Contaldo). Another research topic that started recently is about the use of sampled radio for the implementation of ultralow-power RF transceivers. We are investigating whether the sampling radio architectures that were recently developped for cellular, WLAN and Bluetooth applications can be applied for ultralow-power RF transceivers for WSN applications (PhD candidate A. Heragu). Finally, we are also looking at the design of a flexible sensor interface for in-vivo drug delivery systems using an asynchronous ADC with companding, avoiding the need of any clock and allowing for extending the dynamic range (DR), keeping an almost constant signal-tonoise ratio (SNR) (PhD candidate V. Balasubramanian).

2007-2009 External Grants received at the EPFL SNSF. 2005-2007

CHF 145’795

SNSF. 2006-2007

CHF 54’833

CSEM. 2007-2009

CHF 210’000

Collaborations & Networks Strong collaboration with the CSEM in the field of low-power IC design. Setting up a new collaboration with Prof. Krishna Palem (Rice) and Prof. Zhou Xing (Nanyang Technological University, Singapore), in the field of Probabilistic and Approximate CMOS design. Teaching Activities EPFL Master course “Advanced Analog and RF IC Design I and II” and several Advanced Engineering Courses in the field of low-power, lowvoltage and low-noise analog IC design.tv

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Signal Processing Laboratory 4 Pascal Frossard, Tenure Track Assistant Professor Pascal Frossard is a tenure-track Assistant Professor in the Electrical Engineering Institute of EPFL since 2006, where he heads the Signal Processing Laboratory (LTS4). Between 2001 and 2003, he has been with the Media Delivery Architectures Department of the IBM TJ Watson Research Center (Yorktown Heights, NY, USA. In 2003, he joined the Signal Processing Institute of EPFL as head of the LTS4 laboratory, under a professorship grant from the Swiss National Science Foundation (FNS). Among other technical activities, Pascal Frossard has been the General Chair of ICME 2002 (Lausanne, Switzerland, August 2002). He organized several international conferences in the signal processing area. He serves or has served as Guest Editor of several special issues in image coding and communications. He is an Associate Editor of the IEEE Transactions on Multimedia (2004-), and an Associate Editor of the IEEE Transactions on Circuits and Systems for Video Technology (2006-), and an Associate Editor of the Computer Networks Journal (Elsevier) (2007-). He is an elected member of the IEEE Image and MultiDimensional Signal Processing Technical Committee (2007-), of the IEEE Visual Signal Processing and Communications Technical Committee (2006-), among others. In 2005, he received the prestigious IBM Faculty Award, that recognizes the quality of his research, and its importance to IBM Research strategy. He received in 2008 the IBM Exploratory Stream Analytics Innovation Award. Keywords: Image and Video Processing, Image and Video Coding, Streaming Media, Multimedia Communications, Multimedia Signal Processing, Media Content Delivery Systems. http://lts4www.epfl.ch/

2007-2009 Significant Publications Effrosyni Kokiopoulou and Pascal Frossard, “Classification of multiple observation sets by semisupervised learning”, IEEE Transactions on Pattern Analysis and Machine Intelligence (October 2008). Zafer Arican and Pascal Frossard, “Dense Depth Estimation from Omnidirectional Images”, International Journal on Computer Vision (May 2009). Nikolaos Thomos and Pascal Frossard, “Network coding: from theory to media streaming”, Invited paper, Journal of Communications, Special issue on Multimedia Communications, Networking, and Application (May 2009), Jean-Paul Wagner and Pascal Frossard, “Media-Friendly Distributed Rate Allocation”, IEEE Transactions on Multimedia (March 2008), Ivana Tosic and Pascal Frossard, “Dictionary learning for stereo imaging”, IEEE Transactions on Image Processing (June 2009), Jean-Paul Wagner and Pascal Frossard, “Joint Playback Delay and Buffer Optimization in Scalable Video Streaming”, IEEE Transactions on Circuits and Systems for Video Technology (June 2008). 2007-2009 Awards Exploratory Stream Analytics Innovation Award, IBM Research. Best student paper award, ICPR 2008. Best student paper award, IEEE AVSS 2007. Best Paper Award, Mobimedia 2008.

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Current Group 3 Postdoctoral Fellows 6 PhD Students .25 Administrative Assistant 2 Visiting Students 2 Internship Students 3 Master Students

Research Interests Multimedia communication, image processing, image analysis, image and video compression, distributed signal processing, peer-to-peer streaming, network coding, dimensionality reduction.

2007-2009 Patents Lisa Amini, Pascal Frossard, Effrosyni Kokiopoulou, Olivier Verscheure, “Method and System for robust pattern matching in continuous speech ”: Patent application, filed, May 2008. Jacob Chakareski, Pascal Frossard, “Method of providing Scalable Video Coding (SVC) video content with added media content”: Patent application filed, 2009 Pascal Frossard, Philippe Jost, Pierre Vandergheynst , “System for very low rate face image compression”: Patent application filed 2007 Collaborations & Networks IBM Research, Watson Research Center, NY, USA Nokia Research Center, PeC, Lausanne Prof. Pierre Vandergheynst, EPFL Prof. Patrick Thiran, EPFL Prof. Jean-Philippe Thiran, EPFL Prof. Mihaela van der Schaar, UCLA Prof. de Vleeschouwer, UCL, Belgium Dr Andrea Cavallaro, QMUL, UK Dr Christine Guillemot, INRIA, France Teaching Activities Digital Signal Processing, Bachelor, EE Image Communication, Master, EE/SSC/CS

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Telecommunications Laboratory Christian Gaumier, Head of Laboratory Dr Christian Gaumier (formerly Bungarzeanu) received a Diploma in electrical engineering from the Polytechnic University of Bucharest, Romania, and a Ph.D. from EPFL, in 1983 and 1995, respectively. He joined the Telecommunications Laboratory (TCOM) of EPFL in 1990 and since 2001 he has been Operational Director of TCOM. He has participated in several European research projects such as ACTS 046 and COST Actions 239,266,285 and 291. Dr Gaumier is a member of IEEE and member of the Communication Society of IEEE. Keywords: photonic communication networks, fiber optics transmission, network dimensioning, modeling and simulation http://tcom.epfl.ch/

2007-2009 Significant Publications O. Pedrola, M. Klinkowski, D. Careglio, J. Solé-Pareta, S. Rumley and C. Gaumier, “JAVOBS: A Flexible Simulator for OBS Network Architectures”, Journal of Networks (to be published), S. Rumley, C. Gaumier et al., “Software tools and methods for research and education in optical networks”, Book: Towards digital optical networks (Springer 2009), 332-364 S. Rumley and C. Gaumier, “Multilayer description of large scale communication networks”, Book: Recent advances in modeling and simulation tools for communication networks and services (Springer 2007), 121-136

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Current Group 1 PhD Student 1 Internship Student 2 Erasmus students 1 Master Student

Research Interests Fiber optics transmission - modeling and simulation of signal propagation over single-mode fibers - dispersion compensation techniques - wavelength division multiplexing (WDM) Performance evaluation and dimensioning of photonic communication networks - routing and wavelength assignment - optical burst switching (OBS) architectures - high-capacity “green” transport networks for future internet Network reliability - protection and restoration techniques - survivable networks Modeling and simulation of communication networks - event-driven simulators - discrete-time simulators - hybrid simulation techniques

2007-2009 External Grants received at the EPFL State Secretariat for Education and Research SER 2006-2008

CHF 150’000

EPFL-VPAA 2008-2010

CHF 120’000

Collaborations & Networks Collaborations: Polytechnic University of Catalonia (UPC): Prof. J. Solé-Pareta, Dr D. Careglio University of Zagreb: Prof. B. Mikac, Dr. M. Lackovic Networks: People involved in COST Action 291 http://www.ait.gr/cost291/groups_involved.asp People involved in COST Action 285 http://www.cost285.itu.edu.tr/institut.html Teaching Activities Bachelor: Introduction to transmission systems Master: Optical communications Modulation and transmission

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Nanoelectronic Devices Laboratory Adrian Mihai Ionescu, Associate Professor Director of Doctoral School of Microsystems and Microelectronics Adrian M. Ionescu is an Associate Professor at Ecole Polytechnique Fédérale de Lausanne, Switzerland. He received the B.S./M.S. and Ph.D. degrees from the Polytechnic Institute of Bucharest, Romania and the National Polytechnic Institute of Grenoble, France, in 1989 and 1997, respectively. He held staff and/or visiting positions at LETI-Commissariat à l’Énergie Atomique, Grenoble, CNRS, Grenoble, and Stanford University, Stanford, CA, in 1998 and 1999. He is currently the Director of the Nanoelectronic Devices Laboratory and Director of the Doctoral School of Microsystems and Microelectronics of EPFL.Prof. Ionescu has published more than 200 articles in international journals and conference proceedings. He was the recipient of three Best Paper Awards at international conferences and the Annual Award of the Technical Section of the Romanian Academy of Sciences in 1994. He served on the International Symposium on Quality Electronic Design and International Electron Devices Meeting conference technical committees in 2003, 2004, and 2008 and as Technical Program Committee Chair of the European Solid-State Device Research Conference in 2006.He is a member of the Scientific Committee of the Cluster for Application and Technology Research in Europe on Nanoelectronics (CATRENE) and was appointed as the national representative of Switzerland to the European Nanoelectronics Initiative Advisory Council (ENIAC). Keywords: nanoscale silicon technology, small swing transistors, hybrid NEMS-CMOS, RF MEMS, hybrid SET-CMOS. http://nanolab.epfl.ch/

2007-2009 Significant Publications K. Boucart, A. M. Ionescu, “A new definition of threshold voltage in Tunnel FETs Solid Vol. 52, iss. 9, pp. 1318-1323, September 2008.”, Solid-State Electronics (September 2008), Vol. 52, iss. 9, pp. 1318-1323, September 2008. K. E. Moselund, D. Bouvet, V. Pott, C. Meinen, M. Kayal, A. M. Ionescu, “Punch-through impact ionization MOSFET (PIMOS): From device principle to applications”, Solid-State Electronics (September 2008), Vol. 52, iss. 9, pp. 1336-1344, September 2008. V. Pott, K. E. Moselund, D. Bouvet, L. De Michielis, A. M. Ionescu, “Fabrication and Characterization of Gate-All-Around Silicon Nanowires on Bulk Silicon”, IEEE Transactions on Nanotechnology (November 2008), Vol. 7, iss. 6, pp. 733-744, November 2008. K. Boucart, W. Riess, A. M. Ionescu, “Lateral Strain Profile as Key Technology Booster for All-Silicon Tunnel FETs”, IEEE Electron Device Letters (June 2009), Vol. 30, iss. 6, pp. 656 - 658, June 2009. K. Boucart, A. M. Ionescu, “Double-Gate Tunnel FET With High-k Gate Dielectric”, IEEE Transactions on Electron Devices (July 2007), Vol. 54, no. 7, pp. 1725-1733, July 2007. E. Colinet, C. Durand, L. Duraffourg, P. Audebert, G. Dumas, F. Casset, E. Ollier, P. Ancey, J.-F. Carpentier, L. Buchaillot, A. M. Ionescu, “Ultra-Sensitive Capacitive Detection Based on SGMOSFET Compatible With Front-End CMOS Process”, IEEE Journal of Solid-State Circuits (January 2009), Vol. 44, iss. 1, pp. 247 – 257, January 2009. D. Acquaviva, D. Tsamados, Ph. Coronel, T. Skotnicki, A. M. Ionescu, “Microelectromechanical Metal-Air-InsulatorSemiconductor (MEM-MAIS) Diode: A Novel Hybrid Device for ESD Protection ”, MEMS 2009 (January 2009), Proceedings of MEMS 2009, Sorrento, Italy, 25-29 January 2009. D. Grogg, M. Mazza, D. Tsamados, A. M. Ionescu, “Multi-Gate Vibrating-Body Field Effect Transistors (VB-FETs)”, IEDM 2008, San Francisco, USA, 15-17 December 2008. (Finalist in the IEDM 2008 Student Best Paper Award)”, IEDM 2008 (December 2008), Techn. Digest of IEDM 2008, San Francisco, USA, 15-17 December 2008. G. A. Salvatore, D. Bouvet, A. M. Ionescu, “Demonstration of Subthrehold Swing Smaller Than 60 mV/decade in Fe-FET with P(VDF-TrFE)/SiO2 Gate Stack”, IEDM 2008, San Francisco, USA, 15-17 December 2008.”, IEDM 2008 (December 2008), Techn. Digest IEDM 2008, San Francisco, USA, 15-17 December 2008. D. Grogg, C.T. Tekin, N.D. Ciressan-Badila, D. Tsamados, M. Mazza, A.M. Ionescu, “Bulk Lateral MEM Resonator on Thin SOI With High Q-Factor”, Journal of Microelectromechanical Systems (April 2009), Vol. 18, iss. 2, pp. 466 - 479, April 2009. 2007-2009 Awards 2007 Young Scientist Award, ESSDERC/ESSCIRC TC 2007-09-12 Kathy Boucart was awarded the ESSDERC 2007 Young Scientist Award, in Munich, Germany. This award is a recognition based on her work presented at ESSDERC 2006, in Montreux CH. Title: “Double gate tunnel FET with ultrathin silicon body and high-k dielectric” 20

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Research Interests The Nanoelectronic Devices group (NANOLAB) is working on research subjects in the field of micro/nanoelectronics with special emphasis on the silicon technology, design and modelling of nanoscale solid-state devices (including small subthreshold swing devices, multi-gate FETs, silicon nanowire FETs, hybrid Single Electron Devices - CMOS, ), Radio Frequency MEMS devices for in- and above-IC (silicon resonators, vibrating body FETs as active resonators, CNT resonators and passives, phase shifteres for 3D integration). Among recent energy efficient device concepts invented in the lab one can cite the small swing SG-FET switch and memory, the high mobility bent nanowire transistor and the vibrating FET (active MEM resonator enabling sub-100 microWatt oscillators). Our new device concepts have been regularly reported at the IEEE International Electron Devices Meeting (IEDM) where our laboratory contributed 12 high-level communications in the last 7 years. The lab has 10 US or international patent applications in the last 5 years.

Current Group 4 Scientists 15 PhD Students 1 Administrative Assistant

In general, the group is interested in exploring novel fabrication techniques and disruptive device concepts for future nanoelectronic systems driven by low power consumption and novel functionalities. From 2004 to 2009, 12 PhD students successfully graduated from our laboratory and today, some of them are in key positions at IBM, UC Berkeley, CEA, ISEP Paris or are engaged in innovative start-up companies.

Honorable Mention Award, Conference on VLSI Design TC 2008-01-04 Yogesh Singh Chauhan et al. received an “Honorable Mention Award” for the paper ''Compact Modeling of Suspended Gate FET'', 21th International Conference on VLSI Design, VLSI 2008, Hyderabad, India, 4-8 Jan. 2008.

FP7 European Commission (STREP NEMS-IC) 2007-2010

CHF 900’000

FP7 European Commission (NOE- NANOSIL) 2007-2010

CHF 225’000

Dimitris N. Chorafas Award for best thesis in advaned technology, EPFL CTI SWITZERLAND (MEMS Oscillator) CHF 600’000 2008-07-30 Vincent Pott received the Dr Dimitris N. Chorafas Award for 2008-2011 his thesis entitled “Gate-all-around silicon nanowires for hybrid single electron transistor/CMOS applications” (EPFL thesis #3983, 2008). Collaborations & Networks - partner of European Network of Excellence Nanosil - partner of European Netwrok of Excellence AMICOM 2007-2009 Patents - active participation in ENIAC (prof. Ionescu is member of the A.M. Ionescu, “Ferroelectric Tunnel FET Switch and Memory”: US Scientific Committee) 61/119,734, 04.12.2008 - active participation in CATRENE (prof. Ionescu is member of the Scientifc Committee) A.M. Ionescu, D. Grogg, “Double gate MEM resonators with built-in - active participation in ITRS (prof. Ionescu is the European Chair of the gain”: US 61/115,566, 18.11.2008 Emerging Device Group of ITRS) - bilateral collaboration with Stanford Univeristy, prof. H. S. Philip K. Moselund, A.M. Ionescu, D. Bouvet, “Bended Transistor with Strain Wong induced Mobility Enhancement“: US 12/328, 998, 05.12.2007 - bilateral collaboration with ST Microelectronics K. Moselund, A.M. Ionescu, V. Pott, M. Kayal , “New capacitor-less memory and abrupt switch based on hysteresis characteristics in Teaching Activities punchthrought impact ionization MOS transistor”: US 12/230,557, 29.08.2007 Bachelor Lecture: Microelectronic Devices (28 hours). A.M. Ionescu, D. Grogg, “Multi-gate MEM resonators with intrinsic signal amplification, ”: EP08169367.3, 18.11.2008 2007-2009 External Grants received at the EPFL SNF (RADIO-ON-PAPER) 2007-2009 SNF (FLEXIBLE RADIOS) 2009-2011 SNF (3D Nanowires) 2009-2011 FP7 European Commission (STREP VIACARBON) 2007-2010 FP7 European Commission (STREP PRIMEBITS) 2007-2010

Master Lecture: Nanolectronics (28 hours). Doctoral school lecture: MI-19 Ultimate CMOS and few electron electronics (28 hours).

CHF 250’000 Doctoral school lecture: MI-26 RF MEMS for communications applications (14 hours). CHF 250’000 External lecture: FSRM lecture of RF MEMS (8 hours). CHF 390’000 External lecture: 2009 Tutorial on ‘Sub-kT/q transistors’ at ESSDERC/ ESSCIRC 2009. CHF 750’000 External lecture: 2009 Tutorial on ‘NEM resonators’ at ESSDERC/ ESSCIRC 2009. CHF 450’000 Audit 2009 - Vol. C

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Group Kayal Maher Kayal, Adjunct Professor Section director and Vice-dean for education-STI M.S. and Ph.D degrees in electrical engineering from the EPFL, Switzerland in 1983 and 1989 respectively. Head of the electrical and electronics section since 2003 and vice dean for education of the school of engineering since 2008. Published more than 100 scientific papers with 5 best papers awards, coauthor of three text books dedicated to mixed-mode CMOS design and holds 5 patents. Keywords: Mixed-mode circuits design, CAD tools for microelctronics, Sensors frontend, Analog processing. http://elab.epfl.ch/

2007-2009 Significant Publications Sergio Pesenti, Patrick Clement, Maher Kayal, “Reducing the Number of Comparators in Multi-Bit S/D Modulators”, IEEE Transactions on Circuits and Systems (30/11/2008), 55 (4) pp. 1011-1022 P.A. Dal Fabbro and M. Kayal, “RF power amplifier employing a frequency-tunable impedance matching network based on coupled inductors”, Electronics Letters (30/09/2008), pp. 1131-1132 L. Harik, J-M. Sallese and M. Kayal, “Transient charge pumping as an efficient technique to measure low light intensity with PD SOI MOSFET”, Solid-State Electronics Journal, Volume 52, Issue 5, (30/05/2008), pp 597-605. Pesenti, S. Clement, P. Stefanovic, D. Kayal, M. , “A Low-Power strategy for Delta-Sigma modulators”, Mixed Design of Integrated Circuits and Systems (23/06/2008), pp 203-208 M. Pastre, M. Kayal, H. Blanchard, “A Hall Sensor Analog Front End for Current Measurement with Continuous Gain Calibration”, IEEE SENSORS JOURNALVOL. 7, NO. 5, (22/05/2007), PP 860-867 K.E. Moselund , D. Bouvet, V. Pott, C. Meinen, M. Kayal, A.M. Ionescu, “Punch-through impact ionization MOSFET (PIMOS): From device principle to applications”, Solid-State Electronics Journal 52 (9) (21/03/2008), vol. 52, issue 9, pp. 1336-1344 M. Kayal, R. Cherkaoui, I. Nagel, L. Fabre, F. Emery and B. Rey, “Toward a power system emulation using analog microelectronics solid state circuits”, POWERTECH (14/07/2008), 726-730 D. Stefanovic & M. Kayal, “Structured Analog CMOS Design”, Springer Editor (Book) (02/03/2008), ISBN 978-1-40208572-7 2007-2009 Awards IEEE-Mixdes (Mixed Design of Integrated Circuits and Systems Conference), Best paper award 2007-06-04 Best paper award for the paper entiteld : A low-power Strategy for Delta-Sigma Modulators IEEE-Mixdes (Mixed Design of Integrated Circuits and Systems Conference), Outstanding Paper Award 2009-06-25 Award for the paper entitled: High-Quality Factor MEMS Based Oscillator IEEE Power Tech conference, High quality paper 2009-07-01 Award for the paper entiteld : High-speed, Mixed-signal Emulation for Poer System Dynamic Analysis

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School of Engineering

Research Interests Current Group The general research of my team is the design of mixed mode integrated electronics with emphasis on analog 10 PhD Students aspect. The field of competences was extended, upstream, with the physics of the electronics devices, and 2 PhD Students (external) downstream with the integrated systems. In order to maintain the know-how and achieve a good international visibility a new design methodology based on device behavior has also been developed and encapsulated into CAD platforms. The nano-electronics emerging devices and their integration into the world of electronics functions is a targets of our research activities. The power grid optimization and energy management using low power low voltage analog VLSI emulation approach, is an emerging niche, our achievement in this field is today well established.

2007-2009 Patents Clement Patrick,Kayal Maher,Pesenti Sergio , “Electronic device and integrated circuit comprising a Delta-Sigma converter and method therefore.”: PCT/EP2006/060979 M. Kayal, M. Pastre, M. Blagojevic, L. Portmann, M. Declercq, “Reference Current Generator, and Method of Programming, Adjusting and/or Operating Same”: 2004102631 M. Kayal, ph. Deval, F. Vaucher, “Load and line regulation using operational transconductance amplifier and operational amplifier in tandem”: 20040246052 M. Pastre, M. Kayal, and H. Blanchard, “Continuously Calibrated Magnetic Field Sensor”: 04405584.6 2007-2009 External Grants received at the EPFL Power System Emulation Using Analog Microelectronics (ABB-Research) 2008-2011

CHF 420’000

Micro-projection systems incorporation priorietry MEMS scanning micromirror technology for display applications(CTI) 2009-2011 CHF 331’023 Implementation of widespread IC design skills in advanced deep submicron technologies at European Academia(FP7) 2008-2011 CHF 284’570

Teaching Activities Analog circuits design I [en] (SMT, SEL) Analog circuits design II [en] (SEL) Analog basis structures[fr] (SMT, SEL) Electrical systems & electronics I [en] (SSV) Electrical systems & electronics II [en] (SSV) Electronique I [fr] (SMT SEL) Electronique II [fr] (SPH SMT SEL)

Enabling Autonomous Sensor Nodes: Low-Power Nano-Sensor/ Electronics Building Blocks based on Tunable Carbon Nanotube ElectroMechanical Resonators-CABTURES (Nanoterra) 2009-2013 CHF 301’200 Enabling Autonomous Sensor Nodes: Low-Power Nano-Sensor/ Electronics (Nanoterra funding) 2009-2013 CHF 271’000 Development of an Integrated Circuit Magnetic Sensor having the characteristics of an ideal Hall Cell for use in isolated current transducers (CTI) 2009-2011 CHF 632’100

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Laboratory of Photonics and Quantum Measurements Tobias Kippenberg, Tenure Track Assistant Professor (STI/SB) Project Leader, Max Planck Institute for Quantum Optics Education Habilitation in Experimental Physics, Ludwig-Maximilians-Universität München (LMU) 2009 Ph.D. in Applied Physics, California Institute of Technology 2004 M.S., in Applied Physics, California Institute of Technology 2000 B.A. in Physics, Technical University of Aachen (RWTH) 1998 B.A. in Electrical Engineering, Technical University of Aachen (RWTH) Professional and academic experience Ecole Polytechnique Fédérale de Lausanne (EPFL) Tenure Track Assistant Professor of Physics and Electrical Engineering Sept. 2007-present Max Planck Institute of Quantum Optics, Garching, Germany Marie Curie Excellent Grant Group Leader Jan. 2007-present Leader of an Independent Max Planck Junior Research Group Sept. 2005-present California Institute of Technology, Pasadena, USA Postdoctoral Scholar in the “Center for the Physics of Information” June 2004-Aug. 2005 Graduate Research Assistant in the Micro-Photonics group. March 2000- May 2004 At EPFL since 01/09/2008

2007-2009 Significant Publications A. Schliesser, O. Arcizet, R. Riviere, T.J. Kippenberg, “Resolved sideband cooling of a micromechanical oscillator close to the quantum limit ”, Nature Physics (2009), J. Dobrindt, I. Wilson-Rae, T.J. Kippenberg, “Parametric Normal Mode Splitting in Cavity Optomechanics ”, Physical Review Letters (2008), 263602 G. Anetsberger, R. Rivière, A. Schließer, O. Arcizet and T.J. Kippenberg, “Demonstration of Ultra Low Dissipation Optomechanical Resonators on a Chip ”, Nature Photonics (2008), 627 P. Del’Haye, O. Arcizet, A. Schliesser, R. Holzwarth and T.J. Kippenberg, “Full Stabilization of a Microresonator Frequency Comb”, Physical Review Letters (2008), 053903 T.J. Kippenberg and K.J. Vahala, “Cavity Optomechanics: Back-Action at the Mesoscale”, Science (2008), 1172 A. Schliesser, R. Riviere, G. Anetsberger, O. Arcizet, T.J. Kippenberg, “Resolved sideband Cooling of a Mechanical Oscillator”, Nature Physics (2008), 415 P. Del Haye. A. Schliesser, O. Arcizet, T. Wilken, R. Holtzwarth, T.J. Kippenberg, “Monolithic Optical Frequency Comb Generator”, Nature (2007), 1214 I. Wilson-Rae, N. Nooshi, W. Zwerger, T.J. Kippenberg, “Theory of ground state cooling of a mechanical oscillator using dynamical back-action”, Phys. Rev. Lett. (2007), 093901 2007-2009 Awards Fresnel Prize, European Physical Society 2009-06-01, Prize of the EPS given every two years in Quantum Electronics Division Helmholtz Award for Metrology, PTB 2009-07-01, Most prestigious prize in Metrology; given every 2 years 2007-2009 Patents Prof. T. Kippenberg, EU/US patent application , “Monolithic frequency comb generator, ”: EP07009067 Prof. T. Kippenberg, EU/US patent application , “Method for obtaining spectroscopic data using a scanning diode laser and a frequency comb ”:

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Keywords: Cavity Optomechanics, Monolithic Optical Frequency Combs, Ultra Sensitive Biophysical Current Group 1 Adjunct Professor Recognition. k-lab.epfl.ch 0.25 Administrative Assistant 1 Postdoctoral Fellow Research Interests Experimental and theoretical research in ultra high Q optical microcavities and their use in cavity 8 PhD Students optomechanics, frequency comb metrology and quantum measurements of motion.

2007-2009 External Grants received at the EPFL SNF Project (Switzerland), Sept. 2009 - Dec. 2011,

CHF 367’225

Participant: NCCR Quantum Photonics, Sept. 2008 – June 2009,

CHF 130’000

ERC Starting Grant, Sept. 2008 – Aug. 2013,

EUR 888’000

Collaborations & Networks Professor Zwerger, Department of Theoretical Physics, Technical University of Munich, Germany, Quantum theory of radiation pressure cooling and optomechanics 2007-present Dr. Ronald Holzwarth, Max Planck Institute of Quantum Optics /Menlo GmbH, Monolithic frequency comb generators 2007-present Professor J.P. Kotthaus, LMU Munich University (Chair of Solid State Physics), Nanomechanics 2008-present Professor J. Raedler, LMU Munich University (Chair of Biophysics), Dispersive Single molecule detection 2007-present

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Laboratory of Nanoscale Electronics and Structures Andras Kis, Tenure Track Assistant Professor 2004-2007 Postdoc in the group of Prof. Zettl, University of California, Berkeley, USA 2000-2003 PhD student of prof. Forró at EPFL, School of basic sciences, Institut de physique de la matiere complexe, EPFL, Switzerland 1999 Diploma thesis on the subject of the development of microcalorimetric measurements and the measurements of heat capacity of (TaSe4)2I, Institute of Physics, Zagreb, Croatia 1994-1999 Physics department at the University of Zagreb, Croatia 1994 baccalaureate, MIOC high school, Zagreb, Croatia. At EPFL since 01/01/2008 Keywords: Nanoelectronics, nanodevices, nanotechnology. http://lanes.epfl.ch/

2007-2009 Significant Publications T. D. Yuzvinsky, A. M. Fennimore, A. Kis, A. Zettl, “Controlled placement of highly aligned carbon nanotubes for the manufacture of arrays of nanoscale torsional actuators”, Nanotechnology (2007), 17, 434 X. Chen, A. Kis, A. Zettl and C.R. Bertozzi, “A Cell Nanoinjector Based on Carbon Nanotubes”, PNAS (2007), 104, 82188222 A. Kis, G. Csanyi, D. Vrbanic, A. Mrzel, D. Mihailovic, A. Kulik, and L. Forró, “Nanomechanical Investigation of Mo6S9xIx Nanowire Bundles”, Small (2007), 3, 1544-1548 K. Jensen, W. Mickelson, A. Kis, A. Zettl, “Buckling and Kinking Force Measurements on Individual Multiwalled Carbon nanotubes”, Physical Review (2007), B 76, 195436 2007-2009 External Grants received at the EPFL Swiss National Science Foundation (SNSF), 2008-2011 CHF 157’725 European Research Council (ERC), 2009-2014 CHF 2’700’000 Collaborations & Networks Outside EPFL: Dragan Mihailovic, Department of Complex Matter, Institut “Jozef Stefan”, Ljubljana, Slovenia Teaching Activities Master’s level course, “Physical models for micro and nanosystems”

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Research Interests Current Group The research in the Laboratory of Nanoscale Electronics and Structure is concentrated on developing the 3 PhD Students next generation of advanced nanoelectronic devices based on nanoscale materials such as graphene. The 1 Postdoctoral Fellow group makes extensive use of the EPFL cleanroom where we fabricate our devices. We perform electrical and topological characterisation of devices using an AFM and carry out electrical transport measurements in a He3 cryostat with equipped with a magnet.

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ÂŠ EPFL 2009

Microelectronic Systems Laboratory Yusuf Leblebici, Full Professor Yusuf Leblebici received his Ph.D. degree in electrical and computer engineering from the University of Illinois at Urbana-Champaign (UIUC) in 1990. Between 1991 and 2001, he worked as a faculty member at UIUC, at Istanbul Technical University, and at Worcester Polytechnic Institute (WPI) - where he established and directed the VLSI Design Laboratory. Since 2002, Dr. Leblebici has been full professor and director of the Microelectronic Systems Laboratory at the Swiss Federal Institute of Technology in Lausanne (EPFL). He is coauthor of 4 textbooks, namely, “Hot-Carrier Reliability of MOS VLSI Circuits» (Kluwer Academic Publishers, 1993), “CMOS Digital Integrated Circuits: Analysis and Design» (McGraw Hill, 1st Edition 1996, 2nd Edition 1998, 3rd Edition 2002), “CMOS Multichannel Single-Chip Receivers for Multi-Gigabit Optical Data Communications» (Springer, 2007) and “Fundamentals of High-Frequency CMOS Analog Integrated Circuits» (Cambridge University Press, 2009), as well as more than 150 articles published in various journals and conferences. Keywords: very large-scale integrated circuits and systems, digital and mixed-signal circuits, nanoelectronic device technologies, ultralow-power circuit design, 3D integration, language-based system description and design, reliability and fault-tolerance of nanoelectronic systems, bio-electronic interfaces. http://lsm.epfl.ch/

2007-2009 Significant Publications M. H. Ben Jamaa, K. E. Moselund, D. Atienza, D. Bouvet, Ionescu Adrian M, Y. Leblebici, and G. De Micheli, “VariabilityAware Design of Multilevel Logic Decoders for Nanoscale Crossbar Memories”, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems (November 2008), Volume: 27, Issue: 11, page(s): 2053-2067 M. Stanisavljevic, A. Schmid, and Y. Leblebici, “Optimization of Nanoelectronic Systems Reliability under Massive Defect Density Using Cascaded R-Fold Modular Redundancy (CRMR)”, Nanotechnology (November 2008), Vol. 46, No. 19 M. Stanisavljevic, A. Schmid, and Y. Leblebici, “Optimization of the Averaging Reliability Technique using Low Redundancy Factors for Nanoscale Technologies”, IEEE Transactions on Nanotechnology (May 2009), Volume: 8, Issue: 3, page(s): 379-390 A. Tajalli and Y. Leblebici, “Leakage Current Reduction Using Subthreshold Source-Coupled Logic”, IEEE Transactions on Circuits and Systems-II (May 2009), Volume: 56, Issue: 5, page(s): 374-378 A. Tajalli, E. J. Brauer, Y. Leblebici, and E. Vittoz, “Subthreshold Source-Coupled Logic Circuits for Ultra-Low-Power Applications”, IEEE Journal of Solid-State Circuits (July 2008), Volume 43, Issue 7, July 2008 Page(s):1699 - 1710 A. Tajalli and Y. Leblebici, “A slew controlled LVDS output driver circuit in 0.18um CMOS technology”, IEEE Journal of Solid-State Circuits (February 2009), Volume: 44, Issue: 2, page(s): 538-548 A. Tajalli, M. Alioto, and Y. Leblebici, “Improving power-delay performance of ultra low-power subthreshold SCL circuits”, IEEE Transactions on Circuits and Systems-II (February 2009), Volume: 56, Issue: 2, page(s): 127-131 Kikombo A.K, Asai T., Oya T., Schmid A., Leblebici Y., and Amemiya Y., “A Neuromorphic Single-Electron Circuit for Noise-Shaping Pulse-Density Modulation”, International Journal of Nanotechnology and Molecular Computation (April 2009), Vol. 1, No. 2, pp. 80-92

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Current Group 2 Senior Scientists 1 Postdoctoral Fellow 12 Research Assistants 3 Visiting Students 5 Master Students 1 Administrative Assistant 1 Technician.

Research Interests Design of high-speed CMOS digital and mixed-signal integrated circuits. Ultra low-power circuits utilizing subthreshold-mode operation. Novel nanoelectronic components and circuits, reliability and dependability. Embedded reconfigurable architectures for digital signal processing. Library-based synthesis of highperformance datapath elements. High-level design-flow methodologies for system-on-chip design. Silicon implementation of threshold-logic and neural networks. Pipelined data converters for wireless / multimedia applications. Silicon-based opto-electronic interface circuitry for data communication. Highsensitivity biological and chemical sensor interface electronics.

2007-2009 External Grants received at the EPFL Swiss National Fonds (SNF) Project Acronym: PANOPTIC 2009-2012 CHF 479’278 Swiss National Fonds (SNF) Project Acronym: FN-V 2007-2010

CHF 146’500

Swiss National Fonds (SNF) Project Acronym: DVY-LSI 2008-2011

CHF 331’850

NanoTera RTD Project Acronym: CMOSAIC 2008-2012

CHF 562’460

NanoTera NTF Project Acronym: ULP-LOGIC 2008-2009

CHF 99’750

EU Seventh Framework Programme (FP7) Project Acronym: GALAXY 2008-2010 CHF 668’000 BEA Technologies - Oridao 2009-2010

CHF 328’000

Collaborations & Networks Quantum Electronics Group, University of California - Santa Cruz System Energy Efficiency Lab, University of California - San Diego Computer Engineering Laboratory, Delft University of Technology Department of Electrical Engineering, Hokkaido University Embedded Security Laboratory, Ruhr Universitaet - Bochum Department of Electrical Engineering, Koc University IBM Zurich Resarch Laboratory IMEC 3D WLP Technology Group

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Teaching Activities LSM is currently responsible for the following courses: VLSI Design I (SEL - Master) VLSI Design II (SEL - Master) Microcontrollers and introduction to real-time programming (SEL - Bachelor) Microcontrollers (SMT - Bachelor) Introduction to VHDL (SEL - Bachelor) Hardware Systems Modeling I (SEL - Master) Hardware Systems Modeling II (SEL - Master) Test of VLSI Systems (SEL - Master) EDA Labs (SEL - Master)

Activity Report

School of Engineering

Groupe Acoustique Hervé Lissek, Lecturer After a PhD thesis in Acoustics (Les Matériaux Actifs à Propriétés Acoustiques Variables, Université du Maine, Le Mans), Dr. Lissek joined the Laboratoire d’Electromagnétisme et d’Acoustique to supervise the active noise control activities of the Acoustic Research Group, headed by Prof. Mario Rossi. At Prof. Rossi retirement, Dr. Lissek took the leadership of the acoustic research group, and launched several expertise activities, together with new research topics at EPFL. Up to now, Dr. Lissek has been involved in 4 European Projects in the frame of Aircraft Noise (FP5-SILENCE(R), FP6_X3 NOISE, FP7-TEENI, FP7-OPENAIR), and was recently appointed expert by the EC to evaluate research proposals for the 2nd call for projects in Aeronautics within FP7. Dr. Lissek is now heading a team of 6 people , among which 2 PhD students and 2 Scientists. Keywords: acoustics, electroacoustics, active noise control, microphone arrays. http://lema.epfl.ch

2007-2009 Significant Publications Mentzer Fritz Faller Christof Lissek Hervé, “Obtaining Binaural Room Impulse Responses from B-Format Impulse Responses”, Transactions on Audio, Speech and Language Processing 2007-2009 Patents M.B. Lafon N. Roussel J. Martin J.D. Gascuel G. Buchner H. Lissek, “Interactive multimedia user friendly video conference system having sound/vision collectors around horizontal circular screen with local/distant users interacting through screen”: WO200203692-A

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Research Interests The acoustic group’s core competences rely on electroacoustic expertise, namely know-how on loudspeaker and microphone design, acoustic transmission lines description via lumped element models, as well as the design of arrays of transducers for sound reinforcement and acoustic imaging, especially for communication (line arrays, wave field synthesis) applications or noise metrology (beamforming, near-field holography, goniometry). Together with this specific skill, the acoustic group claims a broader acoustic expertise such as the characterization and model of complex sound sources, including structure-fluid interactions, sound propagation models within complex 3D fields including weather effects and other fluid and thermodynamic interactions, and auditory issues of sound (namely psychoacoustics, including sound design).

Current Group 2 Scientists 2 PhD Students 1 Technician 1 Visiting Student 3 Master Student’s

As a combination of these competences, active noise control has become a hot activity of the group in the last decade, leading to the development of practical concepts for active noise cancellation, active impedance control, or the recent shunt loudspeakers techniques used as acoustic absorbers, the core of these developments remaining the electroacoustic transducers. As a consequence of the latter, the acoustic group is investigating new research areas such as acoustic metamaterials, that should lead to acoustic cloaking capabilities.

2007-2009 External Grants received at the EPFL SNF 2008-2010 OFFT - CTI 2008-2009 FOEN - Promotion of Environmental Technologies 2007 FOEN - Promotion of Environmental Technologies 2007

Teaching Activities CHF 123’543 Master’s level: Audio I: MA1 (Electrical Engineering,Microengineering) CHF 48’288 Audio II: MA2 (Electrical Engineering,Microengineering) Laboratory projects: MA1 & MA2 Semester projects: MA2 (Electrical Engineering,Microengineering) CHF 54’128 Master’s projects: MA3 (Electrical Engineering,Microengineering)

FOEN 2007-2008

CHF 56’034 Doctoral level: Active Noise Control: EDEE CHF 19’000

FOEN 2008-2009

CHF 80’000

EU - FP7 2008-2011

CHF 460’000

EU - FP7 2009-2012

CHF 650’000

EU - FP6 2006-2010

CHF 45’000

Collaborations & Networks EPFL level: STI-LENI, STI-LIN, STI-LAI, STI-L,C, SC-LCAV, IDIAP National level: Federal Office for the Environment, Matisa, Logitech, ETEL, ABB-Secheron, Odysis, VeoVox, Codman Neurosciences, European level: SNECMA Moteurs, FP5-SILENCE(R): SNECMA, ROLLS ROYCE, EADS, AIRBUS, ... FP6-X3 Noise (National Focal Point for Switzerland): SNECMA, ROLLS ROYCE, EADS, AIRBUS FP7-TEENI: TURBOMECA, COMOTI, BRUEL & KJAER,MICROFLOWN, ... FP7-OPENAIR: SNECMA, ROLLS ROYCE, EADS, AIRBUS, ...

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Group Mattavelli Marco Mattavelli, Senior Scientist Marco Mattavelli was born in Milano, Italy, on July 18th, 1961. He received his Diploma of Electrical Engineering from the Politecnico di Milano, Milano, in March 1987. Since 1988 he joined the “Philips Research Laboratories» of Eindhoven in the framework of EUREKA-95 (HDMAC) project. Main research activities regarded channel and source coding for optical recording, electronic photography and signal processing of TV and HDTV signals. Since October 1991 he joined the “Signal Processing Laboratory» (LTS) of the “Swiss Federal Institute of Technology» (EPFL) where he got his PhD in 1996 with the thesis: “Motion analysis and estimation: from ill-posed discrete inverse linear problems to MPEG-2 coding». There, he has been involved in various research projects and didactic activities. In summer of 1995 he was visiting researcher at the Center of Operational Research and Applied Mathematics of Cornell University (NY). Since July 96 he joined the “Integrated System Laboratory» (LSI) of EPFL where he has been a promoter and participants to several research projects. collaborations with industries founded by the Swiss National Fund for scientific research and by the Swiss Commission for the technological innovation (CTI). He has been very active in the last 14 years in the ISO/IEC JTC1/SC29/WG11 standardization activities (better known as MPEG), for which he has been for 12 years Chairman of the Implementation Study Group (ISG). For his work and contributions on MPEG-4 implementation issues, in 1998 and in 2003, he received the ISO/IEC Award. He has spent summer 2005 as invited visiting scientist at the Xilinx Research Lab. of San Jose. He is currently leading the “GR-LSM” in the “Laboratory of Microelectronic Systems” of EPFL. Keywords: system desing, HW and SW synthesis, HW and SW codesign. http://gr-lsm.epfl.ch/

2007-2009 Significant Publications Ihab Amer, Christophe Lucarz , Marco Mattavelli, Ghislain Roquier, Mickael Raulet, Olivier Deforges, Jean-Francois Nezan, “Reconfigurable Video Coding: the Video Coding Standard for Multi-core Platforms”, IEEE Signal Processing Magazine, Special issue on Multicore Platforms (To appear in 2009), n.a. Giun (Chris) Lee, Yen-Kuang Chen, Marco Mattavelli, and Euee S. Jang, “Algorithm/Architecture Co-Exploration of Visual Computing: Overview and Future Perspectives”, IEEE Trans. on Circuits and Systems for Video Technology (To appear in 2009), n.a. Ruohua Zhou, Joshua Reiss, Marco Mattavelli and Giorgio Zoia, “A Computationally Efficient Method for Polyphonic Pitch Estimation”, EURASIP Journal on Advances in Signal Processing (To appear in 2009), n.a. Shuvra S. Bhattacharyya, Johan Eker, Jorn W. Janneck, Christophe Lucarz, Marco Mattavelli, Mickael Raulet, “Overview of the MPEG Reconfigurable Video Coding Framework”, Journal of Signal Processing Systems (To appear in 2009), n.a. Christophe Lucarz, Marco Mattavelli, Julien Dubois, “A platform for the development and the validation of HW IP components starting from reference software specifications”, EURASIP Journal on Embedded Systems (To appear in 2009), n.a. Ruohua Zhou, Marco Mattavelli, Giorgio Zoia, “Music Onset Detection Based on Resonator Time Frequency Image”, IEEE Transactions On Audio, Speech And Language Processing (Nov 2008), 1685-1695 Shuvra S. Bhattacharyya, Gordon Brebner, Johan Eker, Jorn W. Janneck, Marco Mattavelli, Carl von Platen, and Mickael Raulet, “OpenDF - A Dataflow Toolset for Reconfigurable Hardware and Multicore Systems”, ACM SIGARCH Computer Architecture News, Special Issue: MCC08 – Multicore Computing 2008 (December 2008), 29-35 Leonel A. Sousa, Noel E. O’Connor, Marco Mattavelli, and Antonio Nunez, “Embedded Systems for Portable and Mobile Video Platforms”, EURASIP Journal on Embedded Systems (2007), 2-6

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Research Interests Fundamental and applied research on methodologies and tools for high level digital system specification, profiling and design space exploration. Theory and design of video coding and video processing systems and multimedia platforms.

Current Group 4 Postdoctoral Fellows 6 PhD Students 1 Engineer 0.5 Senior Technician 0.4 Administrative Assistant 4 Undergraduate Students 1 PhD Student (external)

2007-2009 External Grants received at the EPFL Fond national 2009-2011 EC - FP7 program 2007-2010

CHF 150’000 CHF 1’250’000

CTI 2007-2009

CHF 640’000

Collaborations & Networks Xilinx Res. Lab, Ericsson Res. Lab., Thales Res., INSA Rennes, Mitsubishi Res. Lab. Japan, Teaching Activities Master course: Architectures des systems de traitement de l’information.

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Electromagnetics and Acoustics Laboratory Juan Mosig, Full Professor Chairman of the Space Center, Associated Dean of the College of Humanities, EurAAP Board Chair Juan R. Mosig was born in Cadiz, Spain. He received the Electrical Engineer degree from the Universidad Politecnica de Madrid, Madrid, Spain, in 1973, the Ph.D. degree from the Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, in 1983 and the Telecommunication Engineering Doctorate (UP Madrid) in 1985. Since 1991, he has been a Professor with EPFL and since 2000, he has been the Head of the Laboratory of Electromagnetics and Acoustics (LEMA) at EPFL. He is also currently a member of the EPFL Electrical Engineering Doctoral Programme Committee and in 2009 he has been nominated Associated Dean of the EPFL College of Humanities. In 1984, he was a Visiting Research Associate with the Rochester Institute of Technology, Rochester, NY, and Syracuse University, Syracuse, NY. He has also held scientific appointments with the University of Rennes, Rennes, France, the University of Nice, Nice, France, the Technical University of Denmark, Lyngby, Denmark, and the University of Colorado at Boulder, USA. Dr. Mosig has been a member of the Swiss Federal Commission for Space Applications and he is currently the Chairman of the EPFL Space Center and responsible for many Swiss research projects for the European Space Agency (ESA). Dr. Mosig is currently the chairman of the European COST Project on Antennas ASSIST (2007–2011), and a founding member and acting Chair of the European Association and the European Conference on Antennas and Propagation (EurAAP and EuCAP). Dr. Mosig is a Fellow of the IEEE and has authored five chapters in books on microstrip antennas and circuits and over 100 reviewed journal papers. His research interests include electromagnetic theory, numerical methods, and planar antennas. Keywords: electromagnetics, antennas, microwaves, rf-engineering, numerical analysis. http://lema.epfl.ch

2007-2009 Significant Publications F. Bongard, J. Perruisseau-Carrier and J.R. Mosig, “Enhanced CRLH transmission line”, IEEE Microwave and Wireless Components Letters (2009), accepted. S. Vaccaro, C. Pereira, J.R. Mosig and P. de Maagt, , “An in-flight experiment for combined planar antennas and solar cells (SOLANT) ”, IET Microwaves, Antennas & Propagation (UK) (2009), accepted. S. Lopez-Pena and J.R. Mosig, “Analytical evaluation of the quadruple static potential integrals on rectangular domains to solve 3D electromagnetic problems ”, IEEE Transactions on Magnetics (2009), Vol. 45, Nr. 3, pp. 1320-1323. P. Alitalo, F. Bongard, J.-F. Zürcher, J.R. Mosig and S. Tretyakov, “Experimental verification of broadband cloaking using a volumetric cloak composed of periodically stacked cylindrical transmission-line networks ”, Applied Physics Letters (2009), Vol. 94, pp. 014103. P. Crespo-Valero, I. Stevanovic, D. Llorens del Rio and J.R. Mosig, “, On the coupling integrals arising in the method of moments formulation of laterally bounded structures ”, IEEE Transactions on Microwave Theory and Techniques (2008), Vol. 56, Nr. 12, pp. 2885-2892. H.-S. She, L.-W. Li, S.J. Chua, W.-B. Ewe, O.J.F. Martin and J.R. Mosig, “Enhanced backscattering by multiple nanocylinders illuminated by TE plane wave ”, Journal of Applied Physics (2008), Vol. 104, pp. 1-7. H.Y. She, L.W. Li, O.J.F. Martin and J.R. Mosig, “Surface polaritons of small coated cylinders illuminated by normal incidet ZM and TE plane waves”, Optics Express (2008), Vol. 16, Nr. 2, pp. 1007-1019. D.I. Olcan, I.M. Stevanovic, J.R. Mosig and A.R. Djordjevic, “Diakoptic approach to analysis of multiconductor transmission lines ”, Microwave and Optical Technology Letters (2008), Vol. 50, Nr. 4, pp. 931-936. I. Stevanovic and J.R. Mosig , “Periodic Green’s function for skewed 3-D lattices using the Ewald transformation”, Microwave and Optical Technology Letters (2007), Vol. 49, Nr. 6, pp. 1353-1357. J.R. Mosig, “Erinnerung (A remembrance), ,, 2007.", IEEE Antennas and Propagation Magazine (2007), Vol. 49, Nr. 1, pp. 181-182.

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Research Interests Electromagnetic Theory, Computational Electromagnetics, Numerical Analysis, Integral Equation and Green’s functions in Elecgtromagnetics, Metamaterials, Planar and multilayered antennas, antennas for AeroSpace applications, cavity and waveguide filters, corona and multipactor effects...

2007-2009 External Grants received at the EPFL SNSF (CHUV), 2007-2009

CHF 105’000

IST Portugal and Space Center (PhD Grants) 2008-2012

CHF 300’000

EU/EC FP7 (ARTIC), 2008-2010

Current Group 3 Postdoctoral Fellows 2 Senior Scientists 1 Adjunct Professor 1 Research Associate 1 Engineer 14 PhD Students 1 Scientific Collaborator 5 Master Students

CHF 50’000

EU/EC FP6 (Metamorphose), 2005-2009

CHF 144’000

ESA (Polaris), 2008-2010

CHF 160’000

ESA (H+S), 2009-2011

CHF 150’000

ESA (MAST&BEST), 2008-2011

CHF 300’000

CTI (JAST), 2006-2009,

CHF 360’000

CTI (Feasant), 2008-2010,

CHF 250’000

COST-ESF (IC0603&IC0803), 2008-2012

CHF 320’000

Collaborations & Networks European Coordination Action (ARTIC) European COST projects IC0603 (Chair) & IC0803 EurAAP (Chair) EuCAP Conference Series SEREC and ACES (Board) Metamorphose VI Teaching Activities Undergraduate: Electromagnetics 1 2 (SEL&SSC) ; Radiation and Antennas (SEL,SSC&Physics) Post-graduate: Computational EM (EPFL-PhD EDEE programme & European School of Antennas)

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School of Engineering

Electromagnetic Compatibility Farhad Rachidi, Adjunct Professor President of the International Conference on Lightning Protection (ICLP) Farhad Rachidi received the Ph.D. degree from EPFL in 1991. He worked at the Power Systems Laboratory of the same institute until 1996. In 1997, he joined the Lightning Research Laboratory of the University of Toronto in Canada and from April 1998 until September 1999, he was with Montena EMC in Switzerland. He is currently the head of the EMC Laboratory at EPFL. Farhad Rachidi was the Chairman of the 2008 European Electromagnetics International Symposium. From June 2008, he serves as the President of the International Conference on Lightning Protection (ICLP). He is the Vice-Chair of the European COST Action P18 ’The Physics of Lightning Flash and its Effects’, Associate Editor of the IEEE Transactions on Electromagnetic Compatibility, Deputy Editor-in-Chief of the Journal of Lightning Research, Co-Editor of the Open Atmospheric Science Journal. He was the recipient of the 2005 IEEE Technical Achievement Award, 2005 Technical Committee Award of the CIGRE (International Council on Large Electric Systems) and the 2006 Blondel Medal. He is the author or coauthor of over 300 scientific papers published in reviewed journals and presented at international conferences. Keywords: electromagnetic fields, lightning, disturbances, protection, power system transients. http://emc.epfl.ch

2007-2009 Significant Publications F. Delfino, R. Procopio, M. Rossi, F. Rachidi, and C. A. Nucci , “Lightning return stroke current radiation in presence of a conducting ground: 2. Validity assessment of simplified approaches”, J. Geophys. Res. (2008), 113, D05111, doi:10.1029/2007JD008567 F. Rachidi, et al., “A Review of Current Issues in Lightning Protection of New Generation Wind Turbine Blades”, IEEE Trans. Ind. Electronics (2008), Vol. 55, No 6, pp. 2489-2496 A. Mimouni, F. Rachidi, Z. Azzouz, “A finite-difference time-domain approach for the evaluation of electromagnetic fields radiated by lightning to tall structures”, J. Electrostatics (2008), Vol 866, pp. 504-513 V. Cooray, V.A. Rakov, F. Rachidi, R. Montano, C.A., Nucci, “On the Relationship Between the Signature of Close Electric Field and the Equivalent Corona Current in Lightning Return Stroke Models”, IEEE Trans. on EMC (2008), Vol. 50, No. 4, pp. 921-927 D. Pavanello, F. Rachidi, et al., “ On Return-Stroke Currents and Remote Electromagnetic Fields Associated with Lightning Strikes to Tall Structures. Part I: Computational Models”, J. Geophys. Res. (2007), 112, D13101, doi:10.1029/2006JD007958, 2007. A. Mosaddeghi, D. Pavanello, F. Rachidi, M. Rubinstein, “On the Inversion of Polarity of the Electric Field at Very Close Range from a Tower Struck by Lightning”, J. Geophys. Res. (2007), 112, D19113, doi:10.1029/2006JD008350 D. Pavanello, F. Rachidi, et al., “On Return-Stroke Currents and Remote Electromagnetic Fields Associated with Lightning Strikes to Tall Structures. Part II: Experiment and Model Validation”, J. Geophys. Res. (2007), doi:10.1029/2006JD007959 D. Poljak, F. Rachidi, S. Tkachenko, “Generalized Form of Telegrapher’s Equations for the Electromagnetic Field Coupling to Finite Length Lines above a Lossy Ground”, IEEE Trans. on EMC (2007), Vol. 49, No. 3, pp. 689-697

Audit 2009 - Vol. C Activity Report

2007-2009 Awards IEEE EMC Society 50th Anniversary Distinguished Paper, IEEE EMC Society 2007-08-01, The paper “Influence of a Lossy Ground on Lightning-induced Voltages on Overhead Lines” by F. Rachidi et al. distinguished by the IEEE EMC Society among the most referenced IEEE Trans.on EMC papers Best Paper Award, 29th Int. Conf. on Lightning Protection 2008-06-26, Award given to A. Mosaddeghi (Ph.D. student) Best Paper Award, 29th Int. Conf. on Lightning Protection 2008-06-26, Award given to K. Sheshyekani (Research Assistant) Young Scientist Award, Int. Union of Radio Science (URSI) 2008-08-15, Award given to F. Vega (Ph.D. student) during the 2008 URSI General Assembly in Chicago Landry Award, Landry Association 2008-10-01 Award given to P. Manoochehrnia for his Master’s project (Lightning Statistics in Switzerland, Revisited) 2007-2009 External Grants received at the EPFL Swiss National Science Foundation, 2009-2011

CHF 180’000

Swiss Agency for Development and Cooperation SDC 2009-2012

CHF 360’000

SNF, PNR 57, 2007 - 2009

CHF 310’000

SER, Armasuisse, 2007 - 2010

CHF 225’000

EPFL Cooperation Seed Fund, Swiss Government Scholarship 2008-2009 CHF 70’000 EC 2007-2008

CHF 290’000

EC 2009-2010

CHF 100’000

School of Engineering

Research Interests The research objective of our lab focuses on three main directions: (1) Modeling of lightning discharge and its electromagnetic effects, (2) EMC in electrical power networks, and (3) EMC problems in complex systems, in particular in transportation and space.

Current Group 1 Senior Scientist 1 Administrative Assistant 4 PhD Students 1 Postdoctoral Fellow

Collaborations & Networks The Electromagnetic Compatibility Laboratory has established a very strong record of national and international research collaborations. All the collaborations have resulted in numerous common publications. Teaching Activities EPFL Bachelor 2004 - : F. Rachidi: Introduction to Electrical Engineering 2 (Electrical and Electronics Engineering). 2004-: P. Zweiacker & F. Rachidi: Introduction to Electrical Engineering Laboratories 2 2000 - : F. Rachidi: Electromagnetic Compatibility (Electrical and Electronics Engineering) 2008-: P. Zweiacker: High Voltage Engineering (Electrical and Electronics Engineering) EPFL Master 2005-: F. Rachidi: Wave Propagation along Transmission Lines, (Electrical and Electronics Engineering) 2000-: P. Zweiacker: Electrical Engineering Laboratories 1 and 2 EPFL Doctoral 2004 - : F. Rachidi & R. Cherkaoui: Transient and Dynamic Analysis of Electric Power Systems 2007-: F. Rachidi: Advanced Topics in Electromagnetic Compatibility. EPFL Postgraduate 2001-2004: F. Rachidi: Director and lecturer of Postgraduate Course in Electrical Power Engineering International F. Rachidi: organizer and lecturer of short courses on EMC and lightning

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ÂŠ EPFL 2009

Industrial Electronics Laboratory Alfred Rufer, Full Professor Alfred Rufer (1951) received the M.S. degree from the Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland, in 1976. In 1978, he joined ABB where he was involved in the fields of power electronics and control, such as high-power converters for variable-speed drives. In 1993, he became an Assistant Professor at EPFL. Since 1996, he has been a full Professor and Head of the Industrial Electronics Laboratory, EPFL. He has authored or coauthored several publications on power electronics and applications, and he holds several patents. In Alfred Rufer’s lab, the actual research activities focus on one hand on power converters, where several solutions and applications of multilevel converters have been studied, especially in the field of asymmetric or hybrid topologies. Another important field initiated by Alfred Rufer is dedicated to supercapacitive energy storage, where many applications have been studied or are currently underway. Other new developments have recently been presented, as the example of a low aging, easy to recycle, hybrid energy storage device based on compressed air. In 2006, Alfred Rufer was elected to the IEEE Fellow grade. Keywords: multilevel converters, frequency converters, energy storage, supercapacitors, control strategies, simulation of systems. http://lei.epfl.ch/ Research Interests The Industrial Electronics Lab focuses its research activities along three principal axes. The first concerns power electronics, with the development of new converter structures or topologies, or dedicated to specific applications. Beneath many different application-oriented options, the LEI research includes a specific topic with an original approach, namely the developing of multilevel converters with asymmetric design. The second axis concerns the energy conversion in general, with its management and storage. Because of renewable sources

2007-2009 Significant Publications Graovac, D. ; Katic, A. ; Rufer, A., “Power Quality Problems Villar, I ; Viscarret, U ; Etxeberria-Otadui, I ; Rufer, A, “Global Loss Compensation With Universal Power Quality Conditioning System”, Evaluation Methods for Non-Sinusoidally Fed Medium Frequency Power IEEE Transactions on Power Delivery (2007), vol. 22, num. 2, 968-976 Transformers”, IEEE Transactions on Industrial Electronics (2009), Fahrni, C. ; Rufer, A. ; Bordry, F. ; Burnet, JP., “Storage for Particle Accelerators”, EPE Journal : European Power Electronics and Drives Association Journal (2008), vol. 18, num. 4, p. 5-13 Chaudhuri, T.; Steimer, P.; Rufer, A., “ Introducing the Common Cross Connected Stage (C3S) for the 5L ANPC multilevel inverter”, Proceedings of PESC 2008 : IEEE Power Electronics Specialists Conference (2008), p. 167 - 173 Blanc, C. ; Rufer, A., “Multiphysics and energetic modeling of a vanadium redox flow battery”, Proceedings of ICSET 2008 : IEEE International Conference on Sustainable Energy Technologies (2008), p. 696 - 701 Lemofouet, S. ; Rufer, A., “Efficiency Considerations and Measurements of a Hybrid Energy Storage System based on Compressed Air and Supercapacitors”, EPE Journal : European Power Electronics and Drives Association Journal (2007), vol. 17, num. 4, p. 13-19 Rufer, A. ; Lemofouet, S., “Stockage d’énergie par air comprimé. Un défi pour les circuits d’électronique de puissance”, Revue Internationale de Génie Électrique (RIGE) (2007), vol. 10, num. 5, p. 675-687 Pittet, S. ; Rufer, A., “The Equivalent Electron Density Concept for Static and Dynamic Modeling of the IGBT Base in Soft- and Hard-Switching Applications”, IEEE Transactions on Power Electronics (2007), vol. 22, num. 6, p. 2223 - 2233 Grasser, F. ; Rufer, A., “A Fully Analytical PEM Fuel Cell System Model for Control Applications”, IEEE Transactions on Industry Applications (2007), vol. 43, num. 6, p. 1499 - 1506 Etxeberria-Otadui, I. ; Viscaret, U. ; Caballero, M. ; Rufer, A., “New Optimized PWM VSC Control Structures and Strategies Under Unbalanced Voltage Transients”, IEEE Transactions on Industrial Electronics (2007), vol. 54, num. 5, p. 2902-2914

Audit 2009 - Vol. C Activity Report

2007-2009 Awards First Prize Paper Award, IEEE Transactions on Power Delivery 2008-00-00 J.-M. Meyer and A. Rufer. A DC Hybrid Circuit Breaker With Ultra-Fast Contact Opening and Integrated Gate-Commutated Thyristors (IGCTs). IEEE Transactions on Power Delivery, 21(2):646651, 2006 Prix de l’Innovation, Prix de l’Innovation de l’ETG (Société pour les techniques de l’énergie) pour le travail de thèse 2008-00-00 C. Fahrni. Principe d’alimentation par convertisseurs multiniveaux à stockage intégré. PhD thesis, Lausanne, 2008 ABB Award, ABB Award PhD thesis 2009-00-00 T. Chaudhuri. Cross connected multilevel voltage source inverter topologies for medium voltage applications. PhD thesis, Lausanne, 2008 2007-2009 Patents Sylvain Lemofouet, Alfred Rufer, “MULTISTAGE HYDRAULIC GAS COMPRESSION/EXPANSION SYSTEMS AND METHODS”: PCT/ IB2008/053691. Sylvain Lemofouet, Alfred Rufer, “A MULTISTAGE HYDROPNEUMATIC MOTOR COMPRESSOR”: PCT/IB2007/053700. Aziza Benaboud, Alfred Rufer, “METHOD OF CONTROLLING A THREE LEVEL CONVERTER”: PCT/EP2007/054470. Frédéric Bordry, Burnet Jean-Paul, Claude Fahrni, Alfred Rufer, “DISPOSITIF D’ALIMENTATION D’UNE CHARGE COMPRENANT UN STOCKAGE D’ENERGIE INTEGRE”: PCT/CH2007/000284 Philippe Barrade, Alfred Rufer, “RAPID TRANSFER OF STORED ENERGY - PROJET HYDRID & FAST CHARGING”:

School of Engineering

produce generally electrical power in a form that is not directly compatible with the user specification, as AC-grids, power electronic converters are present in each application of new energy sources. The classical examples are like photovoltaic sources or variable speed wind generators. The third axis concerns the modelling and simulation of systems, as well as the concept and design of control strategies and control circuits. In this field, many new applications need to be investigated from this point of view, and especially when the system complexity increases. Especially for multidisciplinary systems, a dedicated methodology is needed. Power electronics - Multilevel and interleaved converters - Frequency converters with high efficiency - New commutation mechanism

Current Group 1 Scientist 1 Scientific Collaborator 1 Engineer 1 Administrative Assistant 1 Technician Apprentice 7 PhD Students 2 PhD Students (external)

Energy management and storage - Energy storage and applications with supercapacitors, hybrid structures - Power supply with storage for particle accelerators - Hybrid energy storage with compressed air and supercapacitors - Energy storage with Flow batteries

2007-2009 External Grants received at the EPFL PROJET ZEES - IKERLAN, 2008-2012

CHF 35’000

Mader Racing, 2007

CHF 28’800

FN : New commutation mechanisms in dedicated structures for high efficiency power converters and future switching devices 2005-2008 CHF 135’889 EC-UNIFLEX, 2006-2009

CHF 723’230

CTI-Hybrid Energy module for consumer, 2009-2011

CHF 190’712

CTI - Solar Impulse, 2006-2008

CHF 225’000

Alstom : Active Generator Control, 2007-2010

CHF 390’000

ABB : Intelligent Transmission and Distribution Systems 2008-2010

CHF 255’000

Collaborations & Networks UNIFLEX-PM (EC-Project) : University of Nottingham, Genova and Aalborg, AREVA, ABB, Dynax. University of Lille (L2EP) University of Toulouse (LAPLACE) University of Napoli CERN Geneva IKERLAN Arrasate-Mondragón Teaching Activities Power Electronics I & II., Industrial Electronics I & II, Hybrid systems, Informatic Tools, Projects & TP (practical work)

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Group Sallèse Jean-Michel Sallèse, Senior Scientist With a PhD in physics from the CNRS-Sophia Antipolis (France), I joined EPFL in 1991 in the group of Marc Ilegems where I worked on III-V laser diodes characterization and modeling of inter-diffusion in quantum wells and quantum wires structures. Since 1996, I joined the Electronics Laboratories (Prof. Michel Declercq) where my research activities concern modelling MOS field effect transistor for analog design application, addressing different topics such as High Frequency and non quasi-static operation in advanced CMOS technology. I am also currently involved in European projects on nanoscale CMOS device concepts and educational programs. Keywords: Modelling, MOSFET, MEMS, Glucose sensor, ferroelectrics, bistable MEMS

2007-2009 Significant Publications Fabrizio Lo Conte, Jean-Michel Sallese, Marc Pastre, François Krummenacher, Maher Kayal, “Global modeling strategy of parasitic coupled currents induced by minority carriers propagation in semiconductor substrates”, Transaction on electron devices (accepted for publication), Louis Harik, Jean-Michel Sallese, Maher Kayal, “SOI Pixel Based on a Floating Body Partially Depleted MOSFET in a Delta-Sigma Loop ”, IEEE Sensor Journal: (2009), not yet available Harik L, Sallese JM, Kayal M, “High Optical Sensitivity of PD SOI MOSFET’s Using Transient Charge Pumping”, Solid State Electronics (2008), Vol. 52 (5), p.597 Harik, L; Kayal, M; Sallese, JM, “Optical Sensor Using a Floating Body SOI MOSFET in the Delta-Sigma Loop”, IEEE INTERNATIONAL SOI CONFERENCE (2008), p. 91 - 92 Sallese JM, Bouvet D, “Principles of space charge based bi-stable MEMS: The Junction MEMS”, Sensors and Actuators A-Phys (2007), 133, pp 173-179 Roy AS, Enz CC, Sallese JM, “Source-drain partitioning in MOSFET”, IEEE Transaction on Electron Devices (2007), Vol. 54 (6), pp. 1384-1393 Roy AS, Enz CC, Sallese JM, “Noise Modeling in lateral nonuniform MOSFET”, IEEE Transaction on Electron Devices (2007), Vol 54 (8), pp. 1994-2001 2007-2009 Patents SALLESE JM, BOUVET D, “Bistable PN junction MEMS”: US2007217120-A1 SALLESE JM; MURALT P; BOUVET D , “Bistable ferro-electric MEMS”: US2006125746-A1 SALLESE JM, MEURVILLE E, “Viscometric sensor for monitoring analyte levels in a patient”: EP08160352.4

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School of Engineering

Research Interests Our main research activities are twofold: - Development of nanoscaled transistors models that can be used in Computer Assisted Design (CAD) tools to enable circuit design based on emerging multigate MOSFETs technologies. - Innovating MEMS architectures (ferroelectric MEMS-patented) to develop both bistable micro-electromechanical systems as well as new concepts of bio-sensors. More precisely, we are currenly developping a new concept of glucose sensor relying on viscosity measurements (patented) and are now awaiting for funds from a ’Synergia - FNS’ project.

2007-2009 External Grants received at the EPFL SNF-Synergia : New roads for in vivo glucose monitoring 2009-2012 CHF waiting for SNF decision SNF - Fond National de la recherche scientifique 2009-2011

CHF 164’775

European Marie Curie Project (FP7) - Compact Modelling Network 2008-2012 CHF 240’000 Collaborations & Networks Collaborations with : - Dr. Jochen Rentsch, Fraunhofer Institute, Freiburg, Germany - Professor Benjamin Iniguez, Univerisidad Rovira y Virgili, Tarragona, Spain - Professor Wieslaw Kuzsmics, Warsaw Technical University, Warsaw, Poland - Professor Matthias Bucher, Technical University of Creta - Professor Christophe Lallement, Universite Louis Pasteur, Strasbourg, France - Professor Christian ENZ, CSEM, Neuchatel, Switzerland - Professor Peter Ryser, LPM2 laboratories, EPFL. Teaching Activities Master course ‘Modelling emerging electron devices’, which is an optionnal course on state of the art electron devices (28 hours). Doctoral course ’Modeling micro and nano electron devices’. This course is intended to explain th emodelling strategies that are used to depict field effect devices at mesoscopic scale, with special focus on transport mechanims in ultimate MOSFET transistors (14 hours). ‘Idesa Courses’ (http://www.mtc-online.be/mtc/idesa/Courses.html) are course given in various European Universities to train PhD students as well as Lecturer. In this project I give two different lectures (Analog / RF modelling of the MOSFET )

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School of Engineering

Electrical Machinery Laboratory Jean-Jacques Simond, Full Professor Born on February 7, 1946 1968 EPUL, Electrical Engineer Diploma 1976 EPFL, Ph. D in Technical Sciences and Engineering 1969 - 1970 BBC Mannheim Engineer, design of large electrical machines 1970 - 1973 EPFL, research assistant 1973 - 1977 Engineering school of Neuchâtel, professor for electrotechnics 1977 - 1990 BBC / ABB Baden, research and development engineer in the field of large electrical machines, then head of the “Hydro and Diesel Generators” department. 1990 - Full professor at EPFL, director of the LME Affiliation: International steering committees: ICEM, Hydropower and Dams, Electromotion. Keywords: electrical machines, networks, drive systems. http://lme.epfl.ch/

2007-2009 Significant Publications Y. Pannatier, B. Kawkabani, J.-J. Simond, “Modelling and Transient Simulation of FACTS in Multi-Machine Power Systems”, ICEM 2008, Vilamoura (Sept 2008), Conf. proceedings S. Keller, M. Tu Xuan, J.-J.Simond, A. Schwery, “Large low-speed hydrogenerators-unbalanced magnetic pulls and additional damper losses in eccentricity conditions”, Electric Power Applications, IET (Sept 2007), Vol 1, issue 5, pp 657-664 J.-J. Simond, M. Tu Xuan, R. Wetter, “A New Inductive Air-Gap Monitoring System for Large Low Speed Hydro-Generators, Tests in Operation”, IAHR 2008, Iguassu, Brazil (Oct 2008), paper 55 Ch. Nicolet, Y. Vaillant, B. Kawkabani, P. Allenbach, J.-J. Simond, F. Avellan, “Pumped Storage Units to Stabilize Mixed Islanded Power Network ”, HYDRO 2008 Conference (Oct 2008), Conf. proceedings C. Nicolet, B. Greiveldinger, J.-J. Hérou, B. Kawkabani,Ph. Allenbach, J.-J. Simond, F. Avellan, “High Order Modeling of Hydraulic Power Plant in Islanded Power Network”, IEEE-PES, IEEE transactions on Power Systems (Nov 2007), Vol 22, issue 4, pp1870-1880 Keller S., Mai Tu Xuan, Simond J.-J, “Computation of the no-load voltage waweform of laminated salient-pole synchronous generators”, IEEE Transactions on Industry Applications (May/June 2006), Vol 42, issue 3, pp681-687 A. Hodder, J.-J. Simond, A. Schwery, “Double-fed asynchronous motorgenerator equipped with a three-level VSI cascade”, IEEE-IAS Magazine (March/April 2008), vol.14, issue2, pp 32-39 A. Sapin, P. Steimer, J.-J. Simond, “Modelling, Simulation and Test of a Three-Level Voltage-Source Inverter With Output LC Filter and Direct Torque Control”, IEEE Transactions on Industry Applications (March/ April 2007), Vol 43, issue 2, pp 469-475

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Research Interests Modelling and optimisation of large and middle-sized modern electrical machines for energy production and variable speed drive systems. Analysis and simulation of the steady-state and transient behaviour of electrical power networks and adjustable speed drive systems. Development and diffusion of software tools for numerical simulations http://simsen.epfl.ch/. Experimental or virtual determination of parameters and characteristic quantities, data acquisition and processing, UMP monitoring system. Modern electrical networks, HVDC, FACTS, Varspeed units for pumped storage power plants or wind turbines.

2007-2009 External Grants received at the EPFL SIMSEN revenues, each year(mean value), CCEM, 2008-2010

CHF 100’000 CHF 84’000

Alstom Turbogenerators Birr, 2008-2010

CHF 300’000

Alstom Hydro,Birr & CTI, 2008-2010

CHF 215’000

Collaborations & Networks CTI-project nr. 8330.2 EPRP-IW, Alstom Hydro (Switzerland) AG, Concurrent Computing Methodology for Predicting the Hydroacoustic Behaviour of Hydraulic Turbines, Ph.D study Y. Pannatier-Alstom (Switzerland) Alstom Turbogenerators (Switzerland, Birr), Advanced Generator Model for Multiphase Generators, Ph. D study A. Banyai. Voith Hydro, Heidenheim, GermanyResearch Collaboration for Hydroelectric Power Plant Stability (together with the EPFL / LMH / Prof. F. Avellan). Industrial contracts (prototypes, studies, consulting and expertises) with different companies in Switzerland and abroad, especially in relation with our SIMSEN external users. Teaching Activities Electromechanics, Transient Behaviour of Electrical Machines, Power Electronic Systems and Drives, Hybrid Systems (SEL & SGM), doctoral school

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Member of the Acoustics and Electromagnetics Laboratory Anja Skrivervik, Adjunct Professor Anja Skrivervik obtained her electrical engineering degree from Ecole Polytechnique Fédérale de Lausanne in 1986, and her PhD from the same institution in 1992, for which she received the Latsis award. After a stay at the university of Rennes as an invited Research Fellow and two years in the Industry, she returned part time to EPFL as an Assistant Professor in 1996, and is now a “Professeur titulaire» at this institution. Her teaching activities include courses on microwaves and antennas. Her research activities include electrically small antennas, implantable and on body antennas, multifrequency and ultra wideband antennas, numerical techniques for electromagnetics and microwave and millimeter wave MEMS. She is author or co-author of more than 100 scientific publications. She is very active in European collaboration and European projects. She is currently the chairperson of the Swiss URSI, the Swiss representative for COST action 297 and a member of the board of the Center for High Speed Wireless Communications of the Swedish Foundation for Strategic Research. Keywords: microwaves, miniature antennas, antennas for in or on body applications, microwaves and RF-sensors. http://lema.epfl.ch

2007-2009 Significant Publications A.K. Skrivervik, “Design, chap. 2 in the Handbook of Small Antennas, M. Martinez and L. Jofre (ed.)”, edited by the NoE ACE (to be published in 2009), A.K. Skrivervik and M. Gustafsson, “Fundamental Limits, chap 1 in the Handbook of SMall Antennas, M. Martinez and L. Jofre (ed)”, edited by the NoE ACE (to be published in 2009), G. Quintero, J.-F. Zürcher and A. Skrivervik, “Planar elliptical differential antenna for UWB applications, chapter in Ultrawideband, short-pulse electromagnetics 9”, Springer Verlag (2009), J. Perruisseau-Carrier and Anja K. Skrivervik, “Monolithic MEMS-Based Reflectarray Cell Digitally Reconfigurable Over a 360 ° Phase Range”, IEEE Antennas and Wireless Propagation Letters, Volume 7 (2008), 138-141 A.K. Skrivervik, M. Martinez-Vasquez and J.R. Mosig, “On the practical design of small terminal antennas for mobile applications”, IEICE Transactions on Communications, Vol. E91-B, Nr. 6 (2008), 1689-1696 A.K. Skrivervik and J.R. Mosig, “Considerations on terminal antenna design and analysis”, Proc. IEEE 19th International Symposium on Personal, Indoor and Mobile Radio Communications, invited paper (2008), 1-6 J. Perruisseau-Carrier, A. K. Skrivervik, “A Bloch wave approach to the design of optimally matched non-effective medium composite right/left handed transmission lines”, Proc. IET Microw., Antennas Propag., vol. 1, no. 1 (2007), 50-55 A. Skrivervik, J. Perruisseau-Carrier, “MEMS reconfigurable antennas”, keynote paper in MEMSWAVE 2007 (2007), 1-6

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School of Engineering

Current Group Research Interests The group’s broader research interests are centered on the integration of antennas to non conventional or 1 Postdoctoral Fellow harsh communication environments. Topics studied comprise sub-miniature antennas, wearable and in body 4 PhD Students implanted antennas, miniature sensors, UWB and reconfigurability. In these topics, the laboratory’s expertise covers the entire spectrum from theoretical analysis, development of efficient simulation tools, breadboarding and characterization. The latter point involves the set up of dedicated measurement techniques. Latest achievements include the design of a subminiature antenna for a glucometer deeply implanted in the body, which currently sets the standart for what can be achieved in the field of in body communications. The working freqeuncy is 404MHz and the antenna size 9x6x6 mm.

2007-2009 External Grants received at the EPFL SFN (sinergia) 2009-2011

CHF 130’000

SFN (PRN MICS, phase III) 2009-2011

CHF 150’000

Collaborations & Networks President of the swiss URSI Swiss URSI comission B representative Board member of the Swedish Center for High Speed Wireless Communication Member of the Platform for Mathematics, Astronomy and Physics of the Swiss National Academy of Science Swiss represntative of the COST297 action on High Altitude Platforms (HAPCOS) Member of the EurAAP (European Association on Antennas and Propagation) working groups of Small Antennas, European School of Antennas and Social Aspects

Phonak 2009

CHF 17’000

OFCOM 2010

CHF 50’000

EU (Marie Curie Action) 2007-2010

CHF 25’000

CTI (with Vibrometer SA) 2008-2010

CHF 241’000

CTI (with UniNe & IP01) 2007-2009

CHF 110’000 Teaching Activities Microwaves (SEL & SSC) CHF 110’000 Advanced Microwaves (EDEE, EDIC) Participation in 4 modules of the European School of Antennas (Doctoral Program comprising more than 26 Institutions)

CTI (with CSEM&Stratxx) 2007-2009

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School of Engineering

Group for Fibre Optics Luc Thevenaz, Adjunct Professor Luc Thévenaz received in 1982 the M.Sc. degree in astrophysics from the Observatory of Geneva, Switzerland, and in 1988 the Ph.D. degree in physics from the University of Geneva, Switzerland. He developed at this moment his field of expertise, i.e. fibre optics. In 1988 he joined the Swiss Federal Institute of Technology of Lausanne (EPFL) where he currently leads a research group involved in photonics, namely fibre optics and optical sensing. His main achievements are: - the invention of a novel configuration for distributed Brillouin fibre sensing based on a single laser source, resulting in a high intrinsic stability making for the first time field measurements possible, - the development of a photoacoustic gas trace sensor using a near infra-red semiconductor laser, detecting a gas concentration at the ppb level, - the first experimental demonstration of optically-controlled slow & fast light in optical fibres, realized at ambient temperature and operating at any wavelength since based on stimulated Brillouin scattering. The first negative group velocity of light was also realized in optical fibres using this approach. In 1991, he visited the PUC University in Rio de Janeiro, Brazil where he worked on the generation of picosecond pulses in semiconductor lasers. In 1991-1992 he stayed at Stanford University, USA, where he participated in the development of a Brillouin laser gyroscope.

2007-2009 Significant Publications M. Gonzalez Herraez L. Thévenaz, "Physical limits to broadening compensation in a linear slow light system", Optics Express (2009), 17, 4732-4739 L. Thévenaz, "Slow and fast light in optical fibres", Nature Photonics (2008), 2, 474-481 A. Zadok E. Zilka A. Eyal L. Thévenaz M. Tur, "Vector analysis of stimulated Brillouin scattering amplification in standard single-mode fibers", Optics Express (2008), 16, 21692-21707 S. Chin M. Gonzalez-Herraez L. Thévenaz, "Self-advanced fast light propagation in an optical fiber based on Brillouin scattering", Optics Express (2008), 16, 12181-12189 J.P. Besson S. Schilt L. Thévenaz, "Molecular relaxation effects in hydrogen chloride photoacoustic detection", Applied Physics B: Lasers and Optics (2008), 90, 191-196 A. Vedadi D. Alasia E. Lantz H. Maillotte L. Thévenaz M. Gonzalez-Herraez T. Sylvestre, "Brillouin optical time-domain analysis of fiber-optic parametric amplifiers", IEEE Photonics Technology Letters (2007), 19, 179-181 J.C. Beugnot T. Sylvestre D. Alasia H. Maillotte V. Laude A. Monteville L. Provino N. Traynor S.F. Mafang L. Thévenaz, "Complete experimental characterization of stimulated Brillouin scattering in photonic crystal fiber", Optics Express (2007), 15, 15517-15522 2007-2009 Awards Plenary talk, IEEE, 2007-10-03 International Symposium on Intelligent Signal Processing WISP 2007 Invited talk, Optical Society of America, 2008-03-03, Optical Fiber Communication Conference Invited talk, Optical Society of America, 2009-06-02, CLEO/IQEQ Conference Program Chairman, Optical Society of America, 2009-07-13, Program Chairman of the Topical Meeting on Slow & Fast Light Tutorial presentation, Optical Society of America 2009-11-02, Asia Communications and Photonics Conference

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He joined in 1998 the company Orbisphere Laboratories SA in Neuchâtel, Switzerland, as Expert Scientist to develop gas trace sensors based on photoacoustic laser spectroscopy. In 1998 and 1999 he visited the Korea Advanced Institute of Science and Technology (KAIST) in Daejon, South Korea, where he worked on fibre laser current sensors. In 2000 he co-founded the spin-off company Omnisens that is developing and commercializing advanced photonic instrumentation. In 2007 he visited Tel Aviv University where he studied the all-optical control of polarization in optical fibres. In 2008 he visited Shanghai JiaoTong University, China, where he peformed teaching and research activities on slow & fast light.

Current Group 3 Postdoctoral Fellows 3 PhD Students 0.2 Administrative Assistant 1 Visiting Student

He is author or co-author of some 250 publications and 5 patents. Keywords: Fibre Optics, Optical & fibre optics sensors, Optical communication, Optical signal processing, Slow & Fast Light. Research Interests Nonlinear fibre optics, Optical signal processing, Brillouin-scattering distributed fibre sensors, Slow & fast light, Optical storage, Laser spectroscopy in gases, Optical metrology.

2007-2009 External Grants received at the EPFL SNF, 2009-2010 Interreg IVa, 2009-2011 Interreg IIIa, 2008 FP7 STREP European Project, 2008-2011

Collaborations & Networks CHF 156’000 Chairman of the European COST Action 299 "FIDES: Optical Fibres for New Challenges Facing the Information Society" (72 participating CHF 160’000 Institutions from 21 countries) CHF 110’000 Member of the Consortium in the FP7 European Project GOSPEL “Governing the speed of light” (8 Institutions) CHF 340’000

EPFL STI seed fund, 2007-2008

CHF 140’000 Teaching Activities Introduction to optical processing [fr] (SSC SEL) CHF 55’000 Optical signal processing [en] (SSC SEL)

EPFL Space Center, 2008-2011

CHF 165’000

CTI, 2008-2009

CHF 187’000

European Space Agency, 2007-2009

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Signal Processing Laboratory 5 Jean-Philippe Thiran, Tenure Track Assistant Professor Jean-Philippe Thiran was born in Namur, Belgium, in 1970. He received the Elect. Eng. and Ph.D. degrees from the Université catholique de Louvain (UCL), Louvain-la-Neuve, Belgium, in 1993 and 1997, respectively. He joined the Signal Processing Laboratory (LTS) of the Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland, in February 1998 as a Senior Lecturer. Since January 2004, he has been an Assistant Professor, responsible for the Image Analysis Group (LTS5). He is the editor of 1 book, author or co-author of 5 book chapters, 73 journal papers, and some 120 peer-reviewed conference papers. He holds 4 international patents. Dr. Thiran was Co-Editorin-Chief of Signal Processing (published by Elsevier Science) from 2001 to 2005. He is currently an Associate Editor of two international journals.He is a senior member of the IEEE. Keywords: image segmentation, image analysis, image processing, medical imaging http://lts5www.epfl.ch/

2007-2009 Significant Publications M. Gurban and J.-Ph. Thiran, “Information theoretic feature extraction for audio-visual speech recognition", IEEE Trans. on Signal Processing, in press (2009), L. Gui, J.-P. Thiran and N. Paragios, “Cooperative Object Segmentation and Behavior Inference in Image Sequences", International Journal of Computer Vision (2009), Vol. 84, Nr. 2, pp. 146-162 S. Gorthi, V. Duay, N. Houhou, M. Bach Cuadra, U. Schick, M. Becker, A.S. Allal and J.-P. Thiran, “Segmentation of head and neck lymph node regions for radiotherapy planning, using active contour based atlas registration", IEEE Journal of selected topics in signal processing (2009), Vol. 3, Nr. 1, pp. 135-147 C. Honey, O. Sporns, L. Cammoun, X. Gigandet, J.-P. Thiran, R. Meuli and P. Hagmann, “Predicting Human Resting-State Functional Connectivity from structural Connectivity", Proceedings of the National Academy of Sciences of the USA (2009), Vol. 106, Nr. 6, pp. 2035-2040 I. Bogdanova, X. Bresson, J.-Ph. Thiran and P. Vandergheynst, , “Scalespace analysis and active contours for omnidirectional images", IEEE Transactions on Image Processing (2007), Vol. 16, Nr. 7, pp. 1888-1901 X. Bresson, S. Esedoglu, P. Vandergheynst, J. Thiran and S. Osher, “Fast Global Minimization of the Active Contour/Snake Model", Journal of Mathematical Imaging and Vision (2007), Vol. 28, Nr. 2, pp. 151-167 L. Jonasson, X. Bresson, J. Thiran, V. Wedeen and P. Hagmann, “Representing Diffusion MRI in 5D Simplifies Regularization and Segmentation of White Matter Tracts", IEEE Transactions on Medical Imaging (2007), Vol. 26, Nr. 11, pp. 1547-1554 2007-2009 Patents Claudio Pollo and Jean-Philippe Thiran, “Adjustable stereotactic tripod: material and method for frameless neurosurgical stereotaxy": PCT/ EP2007/061901

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Research Interests The research activities of the group of Prof. Thiran are dedicated to the development of new methods for robust image analysis, with the ultimate goal of transforming the huge amount of digital visual data produced every day into information and knowledge. Our research specifically addresses the inclusion of prior knowledge in image segmentation, i.e. the mathematical techniques to include different types of prior knowledge available about the image analysis task at hand. Those techniques include partial differential equations and variational methods, behavioral modeling, image registration or atlas-based segmentation. Those methods are applied to various fields including medical image analysis, surveillance, multimodal signal/image analysis, aerial and satellite imaging, etc.

2007-2009 External Grants received at the EPFL Swiss NSF projects, 2007-2012

CHF 347’165

Swiss NSF (SPUM program) 2009-2011

CHF 368’852

Swiss NSF (NCCR’s) 2007-2013

CHF 815’151

Nestlé 2008-2009

CHF 256’000

Interreg 2008-2011

CHF 100’000

ETH Rat (NCCBI) 2008-2012

CHF 169’700

CTI projects 2009-2010

CHF 528’000

Current Group 6 Postdoctoral Fellows 6 Research Assistants 1 MD 6 PhD Students 1 Administrative Assistant 4 Master Students 2 Erasmus students 2 PhD Students (external) 1 Internship Student

Collaborations & Networks EPFL, e.g Vandergheynst (STI), Frossard (STI), Bierlaire (ENAC), Unser (STI), Barrandon (SV), Gruetter (SB), Magistretti (BMI) Swiss academic institutions: with ETH Zurich, the University Hospitals of Lausanne (CHUV) and Geneva (HUG), the IDIAP Research Institute (Martigny), etc. International academic institutions : e.g. Department of Mathematics at UCLA, the Ecole Centrale de Paris, France, Harvard Medical School, etc. Swiss industry: Nestlé Reseach Centre, SMEs like Atracsys LLC (on medical image segmentation), Fastcom SA (on face detection), VisioWave SA (on behavior analysis for surveillance), etc. International industry: with Philips Medical Systems (MEDISYS group, Paris, France). Teaching Activities Bachelor level: Introduction to Signal Processing, EE section Master level: - Image analysis and pattern recognition EE section - Image processing I & II, taught to 5 sections Doctoral level: Advanced image processing and analysis. Privat-Docent (lecturer) at the University of Lausanne.

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Signal Processing Laboratory 2 Pierre Vandergheynst, Associate Professor Director of Doctoral Program in Electrical Engineering Pierre Vandergheynst received the M.S. degree in physics and the Ph.D. degree in mathematical physics from the Université catholique de Louvain, Louvain-la-Neuve, Belgium, in 1995 and 1998, respectively. From 1998 to 2001, he was a Postdoctoral Researcher with the Signal Processing Laboratory, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland. He was Assistant Professor at EPFL (2002-2007), where he is now an Associate Professor. His research focuses on harmonic analysis, sparse approximations and mathematical image processing with applications to higher dimensional, complex data processing. He was co-Editor-in-Chief of Signal Processing (2002-2006) and is Associate Editor of the IEEE Transactions on Signal Processing (2007-present). He has been on the Technical Committee of various conferences and was Co-General Chairman of the EUSIPCO 2008 conference. Pierre Vandergheynst is the author or co-author of more than 50 journal papers, one monograph and several book chapters. He’s a senior member of the IEEE, a laureate of the Apple ARTS award and holds seven patents. Keywords: signal processing, image processing, information technology http://lts2www.epfl.ch/ Research Interests Signal, Image and Information Processing. Applied mathematics

2007-2009 Significant Publications Y. Wiaux, L. Jacques, G. Puy, A.M.M. Scaife and P. Vandergheynst, “Compressed sensing imaging techniques for radio interferometry”, Monthly Notices of the Royal Astronomical Society (2009), vol. 395, 2009, p. 1733 K. Schnass and P. Vandergheynst, “Dictionary preconditioning for greedy algorithms”, IEEE Transactions on Signal Processing (2008), vol. 56, num. 5, 2008, p. 1994-2002 H. Rauhut, K. Schnass and P. Vandergheynst, “Compressed sensing and redundant dictionaries”, IEEE Transactions on Information Theory (2008), vol. 54, num. 5, 2008, p. 2210-2219 R. Gribonval, H. Rauhut, K. Schnass and P. Vandergheynst, “Atoms of all channels, unite! Average case analysis of multichannel sparse recovery using greedy algorithms”, Journal of Fourier Analysis and Applications (2008), vol. 14, num. 5, 2008, p. 655-687 Y. Wiaux, J.D. McEwen, P. Vandergheynst and O. Blanc, “Exact reconstruction with directional wavelets on the sphere”, Monthly Notices of the Royal Astronomical Society (2008), vol. 388, 2008, p. 770 I. Bogdanova, X. Bresson, J. Thiran and P. Vandergheynst, “Scale-space analysis and active contours for omnidirectional images”, IEEE Transactions on Image Processing (2007), vol. 16, num. 7, 2007, p. 1888-1901 Bresson, X. ; Esedoglu, S. ; Vandergheynst, P. ; Thiran, J. ; Osher, S., “Fast Global Minimization of the Active Contour/Snake Model”, Journal of Mathematical Imaging and Vision (2007), vol. 28, num. 2, 2007, p. 151-167 Y. Wiaux, L. Jacques and P. Vandergheynst, “Fast spin +-2 spherical harmonics transforms and application in cosmology”, Journal of Computational Physics (2007), vol. 226, 2007, p. 2359 2007-2009 Awards Apple Research and Technology Support Award, Apple 2007-10-10 Award & Sponsorship received from Apple for the project entitled “Processing the Universe’s first pictures” IEEE Best Young Author paper award, IEEE Signal Processing Society 2008-01-01 Paper award for a paper published in the IEEE Trans. Image Processing

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Current Group 1 Administrative Assistant 4 Postdoctoral Fellows 6 PhD Students

2007-2009 External Grants received at the EPFL SNF 2007-2008

CHF 100’942

SNF 2007-2010

CHF 207’200

SNF 2009-2012

CHF 469’825

Nokia 2009 Merck-Serono 2009-2011

CHF 50’000 CHF 200’000

INRIA 2007 - 2010

CHF 40’000

EU - FP7 2008-2010

CHF 606’216

EU - FP7 2009 - 2011

CHF 460’000

Apple 2007

CHF 40’000

Collaborations & Networks INRIA, France Paris VI and VII, France UCL, Belgium Cambridge, UK Queen Mary University, London, UK Technion, Israel Teaching Activities Signal and Systems II, BS SSV Signal and Systems II, BS SMT Advanced Signal Processing, MS SEL Advanced Image Processing and Analysis, Doc. School EDEE & EDIC

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Group Vesin Jean-Marc Vesin, Senior Scientist Jean-Marc Vesin graduated from the Ecole Nationale Supérieure d’Ingénieurs Electriciens de Grenoble (ENSIEG, Grenoble, France) in 1980. He received his M. Sc. from Laval University, Québec city, Canada, in 1984, where he spent four years on research projects. After two years in the industry, he joined the Signal Processing Institute (ITS) of the Swiss Federal Institute of Technology, Lausanne, Switzerland, where he obtained his Ph. D. in 1992. Since then, he has been in charge of the activities in one-dimensional signal processing first inside ITS, and now with its own group LTS 1. His main interests are biomedical signal processing, adaptive signal processing, and nonlinear signal modeling and analysis. He has authored or co-authored more than fifty publications in renowned peer-reviewed journals, as well as several book chapters. Keywords: adaptive filtering, adaptive frequency tracking, robust spectral estimation, nonlinear signal modeling, electrocardiogram, electro-encephalogram, financial time series lts1www.epfl.ch

2007-2009 Significant Publications Y. Prudat and J.-M. Vesin, "Multi-signal extension of adaptive frequency tracking algorithms", Signal Processing (2009), (89) 963-973 M. Lemay, Y. Prudat, V. Jacquemet, and J.-M. Vesin, "Phase-rectified signal averaging used to estimate the dominant frequencies in ECG signals during atrial fibrillation", IEEE Trans Biomed Eng. (2008), 55(11):2538-2547 U. Hoffmann, J.-M. Vesin, T. Ebrahimi, and K. Diserens, "An efficient P300-based brain-computer interface for disabled subjects", J. Neuroscience Methods (2008), 167(1):115-125 P. Besson, V. Popovici, J.-M. Vesin, J.-P. Thiran, and M. Kunt, "Extraction of audio features specific to speech production for multimodal speaker detection", IEEE Trans. Multimedia (2008), 10(1):6373 A. van Oosterom, Z. Ihara, V. Jacquemet, and R. Hoekema, "Vectocardiographic lead systems for the characterization of atrial fibrillation", Journal of Electrocardiology (2007), 40(4):343.e1-343.e11 E. Pruvot, F. Jousset, P. Ruchat, J.-M. Vesin, Y. Prudat, T. Zerm, and M. Fromer, "Propagation velocity kinetics and repolarization alternans in a free-behaving sheep model of pacing-induced atrial fibrillation", Europace (2007), 9(6):83-88 M. Lemay, J.-M. Vesin, A. van Oosterom, V. Jacquemet, and L. Kappenberger, "Cancellation of ventricular activity in the ECG: Evaluation of novel and existing methods.", IEEE Trans Biomed Eng (2007), 54(3):542-546 Z. Ihara, A. van Oosterom, V. Jacquemet, and R. Hoekema., "Adaptation of the standard 12-lead electrocardiogram system dedicated to the analysis of atrial fibrillation", Journal of Electrocardiology (2007), 40(1):68.e1-68.e8

Audit 2009 - Vol. C Activity Report

School of Engineering

Research Interests The activities of our group are at the interface between advanced signal processing techniques and fundamental and applied biomedical investigations. We are developing adaptive filtering techniques, especially adaptive frequency tracking ones, robust spectral estimation and time-frequency analysis methods, as well as nonlinear interdependence and complexity tools.

Current Group 5 Postdoctoral Fellows 4 PhD Students 1 PhD Student (external) 1 Group Leader

With regard to biomedical applications, our main field of investigation has been for several years the atrial fibrillation, the most common cardiac arrhythmia. We are currently working on the analysis of the complexity of fibrillation dynamics for diagnosis and prognosis purposes, and on anti-arrhythmia pacing strategies. In these lines of research we rely heavily, apart from clinical data, on a computer model of atrial electrical activity that we have developed and improved for almost ten years now. This model allows us to simulate atrial fibrillation in a wide range of physiological conditions. Other biomedical domains we are active in are the electro-encephalogram, gastro-intestinal motility, and accelerometer signals. Also, we have initiated, on the basis of the various processing techniques we have an expertise on, a project on financial time series analysis.

2007-2009 External Grants received at the EPFL SNSF, 2006-2009

CHF 100’000

SNSF, 2006-2009

CHF 100’000

SNSF, 2008-2011

CHF 100’000

CTI, 2007-2010

CHF 220’000

CTI, 2007-2011

CHF 320’000

CTI, 2009-2010

CHF 130’000

CTI, 2008-2011

CHF 275’000

Collaborations & Networks Medical and biomedical partners Our activities in biomedical signal processing has lead us to establish close links with the following groups in Lausanne: - Division of Cardiology, CHUV - Division of Neurology, CHUV - Institute of Physiology, Lausanne University In Switzerland: - Geneva University Hospital - Institute of Physiology, Bern University

Teaching Activities Biomedical Signal Processing (Master level) since 2000 . Introduction to Biomedical Signal Processing (Master level) since 2005. Nonlinear Signal Modeling and Prediction (Doctoral School) since 2004. Data Analysis (sport science master, Lausanne and Geneva universities) since 2009.

Abroad: - Department of Biomedical Engineering, Duke University, USA - Department of Biomedical Engineering, Lund University, Lund, Sweden Signal processing Institutes - Equipe Signal et Image – ENSERB, Bordeaux, France - Laboratoire des Images et Signaux – ENSIEG, Grenoble, France Companies: - Medtronic Europe SA - Schiller AG - Motilis SA - Fundo SA

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Institute of Mechanical Engineering

Laboratory for Hydraulic Machines François Avellan, Full Professor Director of LMH, Chairman of the EPFL High Perfomance Computing Steering Committee In 1977, Prof. François Avellan graduated in Hydraulic Engineering at the INPG Ecole Nationale Supérieure d'Hydraulique, Grenoble France, and, in 1980, got his Doctoral Degree in Engineering from the University of Aix-Marseille II, France, at the Institut de mécanique statistique de la turbulence, CNRS Associate Laboratory. In 1980, he is joining the EPFL Laboratory of Fluid Mechanics as Research Associate and, in 1984, he is appointed Senior Research Associate at the newly created EPFL Institute of Hydraulic Machines and Fluid Mechanics for leading the Research Group in Cavitation. Since 1994, he is Director of the EPFL Laboratory for Hydraulic Machines and he was appointed Ordinary Professor in 2003. In 2001, Prof. François Avellan was elected Head of the Mechanical Engineering Department and he was appointed Deputy Dean of the new EPFL School of Engineering from 2002 to 2006. Since 2002, Prof. F. Avellan is the Chairman of the IAHR Section on Hydraulic Machinery and Systems and he was awarded Honorary Doctorate of the Polytechnic University of Bucharest in October 2003. Keywords: Hydropower Plant, Hydraulic Machinery and Systems, Hydrodynamics, Cavitation Hydroacoustics, Flow Numerical Simulation. http://lmh.epfl.ch/

2007-2009 Significant Publications S. Alligné, C. Nicolet, P. Allenbach, B. Kwakabani, J.-J. Simond, F. Avellan, “Influence of the Francis turbine location under vortex rope excitation on the hydraulic system stability”, International Journal of Fluid Machinery and Systems (October-December 2009), Vol. 2, No. 4, paper O09027S P. Maruzewski V. Hasmatuchi, H.-P. Mombelli D. Burggraeve, J. Iosfin, P. Finnegan, F. Avellan , “Surface roughness impact on Francis turbine performances and prediction of efficiency stepup”, International Journal of Fluid Machinery and Systems (October- December 2009), Vol. 2 No 4 paper O09035S C. Nicolet, S. Alligné, B. Kawkabani, J.-J. Simond, F. Avellan, “Unstable Operation of Francis Pump-Turbine at Runaway: Rigid and Elastic Water Column Oscillation Modes”, International Journal of Fluid Machinery and Systems (October- December 2009), Vol.2, No. 4, paper O09032S P. Maruzewski, D. Le Touzé, G. Oger, F. Avellan,, “SPH High-Performance Computing simulations of rigid solids impacting the free-surface of water”, Journal of Hydraulic Research (November 2009), Accepted to be published C. Nicolet, B. Greiveldinger, J.-J. Hérou, B. Kawkabani, P. Allenbach, J.-J. Simond, F. Avellan , “High-Order Modeling of Hydraulic Power Plant in Islanded Power Network”, IEEE Transactions on Power Systems (November 2007), vol. 22, num. 4, 2007, p. 1870-1880 P. Maruzewski, “ERCOFTAC SIG SPHERIC III International Workshop Proceedings”, Book (June 2008), p. 1-264 X. Escaler, M. Farhat, E. Egusquiza, F. Avellan, “Dynamics and Intensity of Erosive Partial Cavitation”, Journal of Fluids Engineering (July 2007), vol. 129, num. 7, 2007, p. 886-893 M. Iliescu, G. Ciocan, F. Avellan, “Analysis of the Cavitating Draft Tube Vortex in a Francis Turbine Using Particle Image Velocimetry Measurements in Two-Phase Flow”, Journal of Fluids Engineering (February 2008), Vol. 130 021105-1 G. Ciocan, M. Iliescu, T. Vu, B. Nennemann, F. Avellan, “Experimental Study and Numerical Simulation of the Flindt Draft Tube Rotating Vortex”, Journal of Fluids Engineering (February 2007), vol. 129, p. 146

Audit 2009 - Vol. C Activity Report

G. Arpe, C. Nicolet, F. Avellan, “Experimental Evidence of Hydroacoustic Pressure Waves in a Francis Turbine Elbow Draft Tube for Low Discharge Conditions”, Journal of Fluids Engineering (August 2009), Vol. 131 / 081103-1 10 P. Ausoni, M. Farhat, X. Escaler, E. Egusquiza, F. Avellan, “Cavitation Influence on von Kármán Vortex Shedding and Induced Hydrofoil Vibrations”, Journal of Fluids Engineering (August 2007), vol. 129, num. 8, 2007, p. 966-973 C. Chen, C. Nicolet, K. Yonezawa, M. Farhat, F. Avellan, Y. Tsujimoto, “One-Dimensional Analysis of Full Load Draft Tube Surge”, Journal of Fluids Engineering (April 2008), vol. 130, num. 4, 2008, p. 041106:1-6 2007-2009 External Grants received at the EPFL Turbine R&D for HPP Projects in China. VOITH Hydro, Germany. 2007 CHF 211’500 Turbine baseline and comparative tests for the refurbishment of DJERDAP1, Hidroelektrane Djerdap, Serbia. 2008 CHF 310’800 Small hydro turbine R & D tests NIPPON KOEI Power Systems, Japan. 2008-2009 CHF 725’000 Research Project, “Centrale EDF de Sisteron Réhabilitation des groupes 1 et 2 Etude hydraulique”, Electricité de France, France. 2007 CHF 137’183 Research Project SCOPES-SWIRL, “Turbomachinery Swirling Flow Optimization and Control with Technology of Magnetorheological Fluid”. Poly Timisoara, Romania. 2006-2008 CHF 59’500 Research Project HYDRODYNA Phase II “Harnessing the Dynamic Behavior of Hydro Turbines, Storage Pumps and Pump-Turbines”. ALSTOM Hydro, ANSDRITZ Hydro, GE Hydro, VOITH Hydro. 2007-2010 CHF 1’005’000 Research Project HYDRODYNA II - CTI 9189.2, ANDRITZ Hydro. 2008-2010 CHF 755’000 Research Project CTI 8330.2 EPRP-IW “Concurrent Computing Methodology for Predicting the Hydroacoustic Behavior of Hydraulic Turbine”, ALSTOM Hydro, Suisse. 2006-2009 CHF 732’970

School of Engineering

Research Interests The EPFL Laboratory for Hydraulic Machinery is dedicated to the enhancement of knowledge in the field of hydrodynamics applied to turbines, pumps, pump-turbines, hydraulic systems and system performance validation for the next generation of hydropower plants; these power plants being the key components for the development of the future power generation mix of renewable energy. Advanced numerical simulation methods and unique experimental infrastructures enable the EPFL Laboratory for Hydraulic Machines to harness complex hydrodynamics phenomena such as 3D unsteady turbulent separated flow, rotating stall, cavitation, hydro-acoustics and fluid-structure coupling. The EPFL Laboratory for Hydraulic Machinery is internationally renowned for the independent experimental validations of the hydraulic performance of the turbines and pump-turbines performed for the major hydropower plants in the world. The scientific and technical expertise as well as the experimental and computing infrastructure make EPFL a center of scientific excellence in the field of hydraulic machinery and systems and bring the Laboratory research activity at the edge of the turbine technology developments as it is highlighted through its industrial relationships.

Research Project “MCA Numerical Simulation Study of Pressure and Power Surging”, BC Hydro, Canada. 2009 CHF 205’500 Research Project “Hydroelectric Power Plant Stability Improvement by Control Command Optimization”, VOITH Hydro, Germany. 2005-2008 CHF 273’600 Pump-turbines R&D tests, ALSTOM Hydro, France. 2007

CHF 309’300

Pump-Turbine R&D Tests for ALSTOM Hydro, France. 2008

CHF 198’000

Current Group 6 Group Leaders 4 Engineers 6 Technicians 7 Laboratory Assistants 8 PhD Students (external) 1 Scientific Collaborator 1 Master Student 4 Visiting Students

248 MW Turbine acceptance test of PICOTE 2 HPP, ELECTRICITAD DE PORTUGAL, VOITH Hydro, Heidenheim, Germany. 2008 CHF 142’800 220 MW Pump-turbines development and acceptance Tests for the Francis pump-turbines of DONG QING HPP (4 x 220 MW) China, manufacturer ALSTOM Hydro, Grenoble, France. 2007 CHF 596’700 217 MW Turbine acceptance tests for FOZ DE CHAPECO HPP ALSTOM Hydro, France. 2007 CHF 86’500

191 MW turbine acceptance test of BEMPOSTA 2 , ELECTRICITAD DE PORTUGAL, ANDRITZ Hydro. 2009 CHF 110’000 Pump-Turbine baseline and competitive tests for the refurbishment of LUDINGTON PSP. Consumers Energy, MI, USA. 2008-2010 CHF 1’409’700 139 MW Turbine Acceptance test for the ESTREITO HPP CESTE Brazil, VOITH Hydro, Germany. 2008 CHF 182’800 Pump-Turbine Acceptance test for XIANYOU PSP, DONGFANG Electric Machinery Ltd. China. 2009 CHF 270’500 125 MW Turbine acceptance tests for SAO SALVADOR HPP CES, GE Hydro, Brazil. 2007 CHF 202’500 86 MW Turbine baseline tests for PRIEST RAPIDS HPP, PUD N°2 of Grant County, WA, USA. 2009 CHF 174’000 Collaborations & Networks 80 MW Turbine development and acceptance tests for HARMON HPP, 2008-Editor in Chief International Journal of Fluid Machinery and Systems. Ontario Power Generation, ALSTOM Hydro, France. 2002-Chairman of the IAHR Section on Hydraulic Machinery and Systems. 2009 CHF 196’600 1995-Convenor of the Working Group 23 of IEC, International Elecrotechnical Committee, in charge of the new standards concerning 72 MW Turbine development and acceptance tests forLITTLE LONG HPP. model acceptance tests of hydraulic machines. Ontario Power Generation, ALSTOM Hydro, Grenoble, France. 2009 CHF 161’300 Teaching Activities 660 MW Turbine Acceptance test of Nuo Zha Du HPP, HUANENG Mechanical Engineering: B5-Incompressible Fluid Mechanics, Avellan; LANCANGJIANG China, VOITH Hydro Germany. 2008 CHF 239’700 B6-Compressible Flows, Maruzewski; B6-Introduction to Turbomachines, Avellan-Ott; M1-Hydraulic Turbomachines, Avellan; M2-Hydroacoustics, 64 MW Turbine development and acceptance Tests for the refurbishment of Nicolet. SIR ADAM BECK 1 HPP, Ontario Power Generation, American Hydro, PA, Computing Science: M2-Flow numerical simulations in hydraulic USA. 2007 CHF 669’000 turbomachines, Avellan-Maruzewski-Münch, M2-Particle-Based Methods, Maruzewski-Sawley. 500 MW Turbine acceptance tests for REVELSTOCKE HPP BC Hydro, Electrical Engineering: M1-Power Plants, Avellan-Maréchal. VOITH Hydro, Germany. 2007 CHF 387’000 Nuclear Engineering: M1-Hydraulic Turbomachines, Avellan, . 370 MW Pump-turbine acceptance test of XIAN SHUI JAN HPP, Harbin Electric Machinery Ltd. China 2009 CHF 235’000

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Automatic Control Laboratory 1 Dominique Bonvin, Full Professor Dean Bachelor and Master Studies Dominique Bonvin is Professor of Automatic Control and Dean of Bachelor and Master studies at EPFL. He received his Diploma in Chemical Engineering from the ETH, Zürich, and his Ph.D. degree from the University of California, Santa Barbara. He worked in the field of process control for the Sandoz Corporation in Basel and with the Systems Engineering Group of ETH Zürich. He joined the EPFL in 1989 and served as Director of the Laboratoire d’Automatique for the periods 1993-97 and 2003-07 and as Head of the Mechanical Engineering Department in 1995-97. He received twice the Best Paper of the Year Award from the Computers and Chemical Engineering Journal. Keywords: Real-time optimization, Dynamic optimization, System identification, Process chemometrics. http://lawww.epfl.ch/

2007-2009 Significant Publications B. Srinivasan, P. Huguenin and D. Bonvin , “Global Stabilization of an Inverted Pendulum - Control Strategy and Experimental Verification”, Automatica, 45(1) (2009), 265-269 P. Gujral, M. Amrhein and D. Bonvin, “Drift Correction in Multivariate Calibration Models Using On-Line Reference Measurements”, Analytica Chimica Acta, 642(1-2) (2009), 27-36 S. Gros, B. Srinivasan, B. Chachuat and D. Bonvin, “Neighboring-Extremal Control for Singular Dynamic Optimization Problems. Part I: Single-Input Systems ”, Int. J. Control, 82 (6) (2009), 1099-1112 D. Buccieri, Ph. Mullhaupt, D. Perritaz, Z.P. Jiang and D. Bonvin, “Velocity-Scheduling Control for a Unicycle Mobile Robot: Theory and Experiments”, IEEE Trans. Robotics, 25(2) (2009), 451–458 Ph. Mullhaupt, B. Srinivasan, J. Lévine and D. Bonvin, “Control of the Toycopter Using a Flat Approximation”, IEEE Trans. Control Systems Technology, 16(5) (2008), 882-896 L. Miskovic, A. Karimi, D. Bonvin and M. Gevers, “Closed-Loop Identification of Multivariable Systems: With or Without Excitation of All References?”, Automatica, 44(8) (2008), 2048-2056 J. V. Kadam, M. Schlegel, B. Srinivasan, D. Bonvin and W. Marquardt, “Dynamic Optimization in the Presence of Uncertainty: From Off-Line Nominal Solution to Measurement-Based Implementation”, J. of Process Control, 17(5) (2007), 389-398 L. Miskovic, A. Karimi, D. Bonvin and M. Gevers, “Correlation-Based Tuning of Decoupling Multivariable Controllers”, Automatica, 43(9) (2007), 1481-1494

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School of Engineering

Research Interests Automatic control has been a driver of technological progress for many decades. It represents a “hidden” technology that is key to deal with unstable, complex and highly interacting systems in many areas such as energy, environment, health, manufacturing and production, chemical processing, networks, and finances. Our research deals with the identification, control and optimization of dynamical systems. The objective is to enable or improve process operation in the presence of uncertainty that result from a lack of process knowledge or the presence of disturbances. To combat uncertainty, we propose to use measured data to either compute better models or directly optimize process operation. In particular, we have developed methodologies to:

Current Group 1 Senior Scientist 1.95 Scientists 0.5 Technician 0.65 Administrative Assistant 0.5 Trainee 7 PhD Students

1. Identify processes in closed-loop operation, 2. Improve operation by input adjustment based on real-time measurements, 3. Use highly correlated unspecific data such as spectroscopic measurements to monitor and steer (bio)chemical processes. The output of the research is a set of generic methodologies that can be applied indifferently to many areas. Our application areas include systems biology, mechanical devices as well as chemical and biochemical systems.

2007-2009 External Grants received at the EPFL FP6 European Commission 2005-2008

CHF 276’000

Fonds National 2007-2009

CHF 86’000

Fonds National 2007-2010

CHF 131’000

Fonds National 2008-2010

CHF 135’000

Fonds National 2005-2008

CHF 129’000 + 47’000

Fonds National 2009-2012

CHF 247’000

EPFL - STI seed money 2007-2009

CHF 100’000

Collaborations & Networks - Dean of Bachelor and Master Studies at EPFL since 2004 - President of CSU (Commission des Sports Universitaires) UNIL/EPFL since 2005 - Associate Editor of Journal of Process Control since 1990 - Member of IFAC Working Group on Process Control 1990-94 - IPC Co-Chair, IFAC Symp. DYCOPS, Leuven, Belgium 2010 Teaching Activities Two courses each year: - “Dynamical Systems” for Mechanical Engineering students, 4th semester - “Chemical Process Control” for Chemical Engineering students, 6th semester 7 master students in last 3 years Presently, 7 doctoral students

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Activity Report

School of Engineering

Laboratory of Applied Mechanics and Reliability Analysis John Botsis, Full Professor President of STI promotion committee Professor of the Institute of Mechanical Engineering and of the Institute of Materials John Botsis obtained his diplôme in civil engineering at the University of Patras, Greece in 1979. He continued his education at Case Institute of Technology in Cleveland Ohio, where he received his MS and Ph.D. in 1984. After two years at the research center for national defense in Athens he was nominated assistant professor at the University of Illinois in Chicago, associate in 1991 and full professor in 1995. In 1996, he was nominated professor of solids and structural mechanics at the EPFL. From 1/91-3/92 and 1/94-6/94 he was an advisor to the directorate of AFOSR basic research in Washington DC. He has served as a reviewer to several international journals and funding agencies as well as participated in scientific committees of several international conferences. He is member of ASME, SEM, EMS and ISB. Keywords: Mechanical Engineering. http://lmaf.epfl.ch/ Research Interests His research covers the mechanics of solids and structures, fracture mechanics and micromechanics. He is actively involved in full-filed optical methods for surface strain measurements as well as internal strain measurements using fiber Bragg grating sensors, for distributed internal strains in polymers and composites aimed at characterizing micromechanics of fracture, residual strains and strain distribution for structural monitoring. He is equally interested in biomechanics of the periodontal ligament and implants in the oral cavity.

2007-2009 Significant Publications D. KARALEKAS, J. CUGNONI & J. BOTSIS, "Monitoring of hyrgothermal ageing effects in an epoxy resin using FBG sensor: A methodological study", Composites Science & Technology (2009), 69, 507-514 L. HUMBERT, F. COLPO & J. BOTSIS, "An axisymmetric stress analysis in a single fibre composite of finite length under a thermal expansion mismatch", European Journal of Mechanics A (2009), 28, 257-265 H.W.A. WISKOTT, J. CUGNONI, S.S. SHERRER, P. AMMANN, J. BOTSIS, U.C. BELSER, "Bone reactions to controlled loading of endosseous implants – A methodological study", Clinical Oral Implants Research (2008), 19,1093-1102 L. SORENSEN, J. BOTSIS, TH. GMÜR & L. HUMBERT, " Bridging tractions in mode-I delamination: measurements & simulations", Composites Science & Technology (2008), 68, 23502358 M. GALLI, J. BOTSIS & J. JANCZAK-RUSH, " An elastoplastic three dimensional homogenization model for particle reinforced composites", Computational Materials Science (2008), 41,312-321 L. SORENSEN, J. BOTSIS, TH. GMÜR & J. CUGNONI, "Delamination detection and characterization of bridging tractions using FBG optical sensors", Composites Part A (2008), 38, 2087-2096 F. COLPO, L. HUMBERT & J. BOTSIS, "Characterisation of residual stresses in a single fiber composite with FBG sensor", Composites Science & Technology (2007), 67,1830-1841 K. KOMATSU, C. SANCTUARY, T. SHIBATA, A. SHIMADA & J. BOTSIS, " Stress-relaxation and microscopic dynamics of rabbit periodontal ligament", Journal of Biomechanics (2007), 40,634-644

Audit 2009 - Vol. C Activity Report

School of Engineering

Alain Curnier, Adjunct Professor Of French origin and with Swiss nationality, born in 1948, Alain CURNIER holds an Engineer Diploma in Mechanics of the National Institute of Applied Sciences (INSA) at Lyon (1972), a Master of Science (1973) and a Philosophy Doctorate (1978) in Mechanics of Structures of the University of California at Berkeley. He started his career as a Research Engineer at Engineering System International in Paris, from 1978 till 1981, working on several projects in Structural dynamics and Mechanics of materials. He joined the Laboratory of applied mechanics at EPFL in 1981 where he successively became Lecturer in 1981, Scientific advisor in 1987 and Adjunct Professor in 1998. Keywords: Solid mechanics, Contact mechanics, Composite materials, Computational methods, Nonsmooth convex analysis, Biomechanics. http://lmaf.epfl.ch Research Interests His teaching and research activity concerns three fields: Mechanics of solids and rheology of materials, Mechanics of contacts and nonsmooth tribology and finally Biomechanics and biorheology of tissues. His scientific method follows the classical trilogy: experimental observation, theoretical modelling and numerical solution. In particular, he has conceived several original constitutive laws in nonlinear elasticity, viscoelasticity and elastoplasticity for anisotropic composite materials and living tissues at large strains, as well as several tribological laws for unilateral contact, lubrication, friction and adhesion. He has developed a Solid and contact mechanical analysis software called TACT.

2007-2009 External Grants received at the EPFL SNSF UNIGE 1

CHF 28’000

SNSF 2 years

CHF 224’750

SNSF 2 years

CHF 226’575

COST 3

CHF 170’000

Collaborations & Networks Klaus Friedrich, University of Kaiserslautern, D. Alain Vautrin, Ecole Nationale Superieure des Mines de Saint-Etienne, F Paolo Ermanni, ETHZ. Hans Limberger & Rene Salathé, EPFL. Urs Belser, University of Geneva. K. Komatsu, Tsurumi University, Japan Jolanta Janczak-Rush, EMPA. Teaching Activities Mechanics of structures, Mechanics of continuous media, Fracture mechanics. Contact mechanics and tribology Mechanics of composite materials (SGM) Solid mechanics (SGM) Viscoelasticity and elastoplasticity (SGM) Current Group 2 Adjunct Professors 1 Scientific Collaborator 2 Postdoctoral Fellows 5 PhD Students 0.5 Administrative Assistant

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Activity Report

School of Engineering

Computational Engineering Laboratory Michel Deville, Full Professor Michel Deville graduated in Electrical and Mechanical Engineering at the Catholic University of Louvain (UCL, Belgium) in 1968. After his Ph. D. thesis devoted to numerical simulation of fluid flows, he spent his postdoc at the Department of Mathematics of the Massachusetts Institute of Technology in 1974-1975. Afterwards, he carried on his academic career at the Division of Applied Mechanics of UCL successively as assistant professor, professor and full professor. In 1993, he was appointed as full professor of numerical fluid mechanics at the Swiss Federal Institute of Technology in Lausanne. He is consultant for the Division of Numerical Simulation of Flows and Acoustic at ONERA, ChĂ˘tillon, France. Keywords: turbulence modelling, solid and structure modelling http://lin.epfl.ch/

2007-2009 Significant Publications C.Leupi, E. Miglio, M. Altinakar, A. Quarteroni, M. O. Deville, "A 3D Finite element model for free-surface flows", Computers and Fluids (2009), to appear E. Ahusborde, M. Azaiez, M.O. Deville and E.H. Mund, "An iterative domain decomposition algorithm for the grad(div) operator", , Communications in Computer Physics (2009), Vol. 5, pp. 391-397 N. Bodard, R. Bouffanais and M.O. Deville, "Solution of movingboundary problems by the spectral element method", Applied Numerical Mathematics (2008), Vol. 58, pp. 969-984 O. Malaspinas, M.O. Deville and B. Chopard, "Towards a physical interpretation of the entropic lattice Boltzmann method", Physical Review E (2008), Vol. 78, pp. 066705 C. LEUPI, M.S. ALTINAKHAR, M. DEVILLE, "Numerical Modeling of Cohesive Sediments Dynamics in Estuaries: Part I- Description of the model and simulations in the Po River Estuary", Int. J. Numer. Meth. Fluids (2008), 57, pp. 237-263 R. Bouffanais, M.O. Deville and E. Leriche, "Large-eddy simulation of the flow in a lid-driven cubical cavity", Physics of Fluids (2007), Vol. 19, pp. 055108 M.A. Habisreutinger, R. Bouffanais, E. Leriche and M.O. Deville, "A coupled approximate deconvolution and dynamic mixed scale model for large-eddy simulation", Journal of Computational Physics, (2007), Vol. 224, pp. 241-266 O. Malaspinas, G. Courbebaisse and M.O. Deville, "Simulation of generalized Newtonian fluids with the lattice Boltzmann method", International Journal of Modern Physics C (2007), Vol. 18, pp. 19391949

Audit 2009 - Vol. C Activity Report

School of Engineering

ÂŠ EPFL 2009

Research Interests His contributions concern spectral element methods, turbulence modelling, large eddy simulations and nonNewtonian fluids. The applications cover a large spectrum from biomedical engineering to process engineering going through hydrodynamics and aerodynamics. He is the author or co-author of several dozens of papers and four books.

2007-2009 Awards IBM Prize 2008, EPFL This prize in computational science and engineering was awarded to Roland Bouffanais for his thesis entitled: Simulation of shear-driven flows: transition with a free surface and confined turbulence. 2007-2009 External Grants received at the EPFL SNSF: Transient flows of incompressible viscoelastic fluids and stability analysis by spectral methods October 2007 – September 2009 CHF 255’344

Current Group 5 Senior Scientists 1 Postdoctoral Fellow 4 Engineers

Collaborations & Networks ONERA Univ. Bordeaux, Univ. Brussels, LEA Poitiers Teaching Activities Continuum Mechanics, Hydrodynamics, Finite elements for incompressible fluids, Turbulence

SNSF: The Lattice Boltzmann method for the simulation of incompressible viscoelastic fluids October 2007 – August 2009 CHF 92’081 EU: HISAC European Project “Environmentally Friendly High Speed Aircraft “ May 2005 – May 2009 CHF 250’000 EU-ESA:Validation of Aerothermochemistry Models for Re-entry Applications. June 2008 – May 2010

CHF 100’000

EU-ESA: Aerochemistry of radiating ablating turbulent flows December 2008 – November 2012 CHF 135’000 EU-ESA/ESTEC:Aerochemistry of radiating ablating turbulent flows December 2008 – May 2009 CHF 90’000 ESA FLPP Phase 2 ASTRIUM 2007 – 2010

CHF 250’000

CTI: Optimisation du processus de séparation des constituants du sang par simulation numérique November 2007 – October 2009 CHF 229’000 CTI : Coupling of CFD software for the computation of unsteady compressible flows in tunnel networks January 2008 – October 2009 CHF 190’000

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Activity Report

School of Engineering

Group Farhat Mohamed Farhat, Senior Scientist 1985: Engineer degree from Ecole Nationale Supérieur d'Hydraulique et de Mécanique de Grenoble (France) 1986-1995: Research Assistant at EPFL-IMHEF Lab 1994: Ph.D. thesis entiteled: "Cavitation Erosion: Hydrodynamic Mechanisms and Prediction". 1995-1999: Research engineer at R&D department of Hydro-Quebec (Montréal, Canada). Managment of several research projects in the areas of production and transportation of hydropower and mainly the cavitation detection and monitoring in hydraulic turbines. 1999-2009: Lecturer and Group Leader at LMH laboratory since 2009: Senior Scientist at LMH laboratory. Keywords: Hydrodynamics, cavitation and multiphase flows, fluid structure interaction, High speed sailing, hemodynamics, advanced instrumentation. lmh.epfl.ch

2007-2009 Significant Publications Kobel, Philippe ; Obreschkow, Danail ; De Bosset, Aurèle ; Dorsaz, Nicolas ; Farhat, Mohamed, "Techniques for generating centimetric drops in microgravity and application to cavitation studies", Experiments In Fluids (2009), Augsburger, L. ; Reymond, P. ; Fonck, E. ; Kulcsar, Z. ; Farhat, M. ; Ohta, M. ; Stergiopulos, N. ; Rüfenacht, D., "Methodologies to assess blood flow in cerebral aneurysms: Current state of research and perspectives.", Journal of neuroradiology (2009), L. Augsburger, M. Farhat, Ph. Reymond, E. Fonck, Z. Kulcsar, N. Stergiopulos and D. A. Rüfenacht, "Effect of Flow Diverter Porosity on Intraaneurysmal Blood Flow ", Clinical Neuroradiology (2009), 204-214 Chen, Changkun ; Nicolet, Christophe ; Yonezawa, Koichi ; Farhat, Mohamed ; Avellan, François ; Tsujimoto, Yoshinobu, "One-Dimensional Analysis of Full Load Draft Tube Surge", Journal of Fluid Engineers (2008), Escaler, Xavier ; Farhat, Mohamed ; Egusquiza, Eduard ; Avellan, François , "Dynamics and Intensity of Erosive Partial Cavitation", Journal of Fluids Engineering (2007), Ausoni, Philippe ; Farhat, Mohamed ; Escaler, Xavier ; Egusquiza, Eduard ; Avellan, François, "Cavitation Influence on Kármán Vortex Shedding and Induced Hydrofoil Vibrations", Journal of Fluid Engineering (2007), Robert, Etienne ; Lettry, Jacques ; Farhat, Mohamed ; Monkewitz, Peter ; Avellan, François, "Cavitation bubble behavior inside a liquid jet", Physics of Fluids (2007), Liang, Q W ; Rodriguez, C G ; Egusquiza, Eduard ; Escaler, Xavier, "Numerical simulation of fluid added mass effect on a francis turbine runner", Computers & Fluids (2007),

Audit 2009 - Vol. C Activity Report

School of Engineering

Research Interests Objective: Fill the gap between fundamental and applied research Design and perform high level experiments in fluids, using state of the art instrumentation, to further understand the fundamentals, address a large variety of challenging industrial issues and ensure high level education. Ongoing investigations involve physical aspects and industrial applications of cavitation phenomenon, fluidstructure interaction, flow induced vibration and noise, skin friction reduction, high speed centrifugal pumps, pump turbines, hydrodynamic of high speed sailing boats, mixing issues in orbitally shaken bioreactors, hemodynamic of brain aneurysms, ...

2007-2009 External Grants received at the EPFL Voith Siemens Hydro, Germany 2008-2009

CHF 50'000

Current Group 5 Undergraduate Students 2 Internship Students 2 PhD Students (external) 6 Research Assistants

Collaborations & Networks WITHIN EPFL:

Swiss National Science Foundation 2009-2012

- FNSF-Synergia project: orbitally shaken bioreactors for mammalian cell cultivation, collaboratoin between IGM-LMH, LBTC and CMCS CHF 300'000 - Hydroptere:IGM-LMH, IGM-LIN, IGM-LMAF, IMX-LTC, ISIMCVLAB, VPIV - Alinghi : IGM-LMH, IMT-LOA, IMX-LTC, VPIV CHF 710'000 - Brain Aneuryms: IGM-LMH, IBC2-LHTC1

Swiss National Science Foundation 2009-2012

CHF 200'000

Sulzer Pumps AG 2007-2009

CHF 350'000

Swisselectric Research 2007-2010

KTI/CTI 2009

CHF 30'000

Hydroptere: High speed sailling 2007-2010

CHF 720'000

CCEM 2007-2010

CHF 700'000

Andritz Hydro, Switzerland 2007-2009

CHF 60'000

EXTERNAL COLLABORATIONS: - Hydronet Consortium: EPFL-LMH, EPFL-LCH, EPFL-LEME, EPFLEC, EAWAG, EMPA, PSI, HTA-Lucerne - ANDRITZ Hydro - Sulzer Pumps, - European Space Agency, France - Alstom Power, Grenoble. France - Mitsubishi Heavy Industry, Tagasako, Japan - Voith Siemens Hydro, Germany - NYPA, New York Power Authority, USA - TVA, Tennessee Valley Authority, USA - Power Engineering, Orange County, USA - Cambridge University, UK - INSEAN, Italian Ship Model Bassin, Rome - French Naval Academy, Brest, France - Polytechnic University of Catalunya, Barcelona, Spain - Universitﾃｩ d窶連ix Marseille, France - Lulea University, Sweden - Tohuku University, Sendai, Japan - Osaka University, Japan - Hydroptere SA, Switzerland - Alinghi, Switzerland Teaching Activities Master course: Cavitation and Interface Phenomena Doctoral Course: Advance Instrmentatoin in Fluid Mechanics Specialisation Course: Cavitation in Hydraulic Turbines

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Activity Report

School of Engineering

ﾂｩ EPFL 2009

Industrial Energy Systems Laboratory Daniel Favrat, Full Professor Director of the Institute of Mechanical Engineering Daniel Favrat graduated from EPFL with a diploma in Mechanical Engineering in 1972 and a PhD in 1976. Spent more twelve years in industrial energy research centers in Canada (Esso Canada Production Research) and in Switzerland (Atlas Copco European research center). Since 1988 is professor at EPFL and director of the Laboratory for industrial energy systems. From 2002 to 2006 was director of the now dissolved Institute of Energy Sciences, and since 2007 is director of the Institute de Mechanical Engineering. Member of Swiss Academy of Engineering Sciences and vice-chair of the energy committee of the World Federation of Engineering Organisations. Associate editor of the journal “Energy» and member of the editorial board of the journal “Frontiers of energy and power engineering in China». Contributed to a white book on advanced energy technologies (publ.Novatlantis) and is the coauthor of two books on “thermodynamics and energy systems» (publ."PPUR/EPFL Press»). Invited for sabbatical stays at University of Tokyo, MIT, TU Munchen, Ecole des Mines de Paris. Keywords: energy systems modeling & optimisation, thermodynamics,heat pumps &ORC,fuel cells,thermal power,combustion http://leniwww.epfl.ch/

2007-2009 Significant Publications SCHIFFMANN J., FAVRAT D., "Experimental investigation of a direct driven radial compressor for domestic heat pumps", Int. J. of Refrigeration (in Press) (2009), NAKAJO A WUILLEMIN Z, VAN HERLE J, FAVRAT D, "Simulation of thermal stresses in anode-supported solid oxide fuel cell stacks Part 1 and II.", Journal of power sources (2009), pp203-226 HEYNE S., MEIER M.,IMBERT B.,FAVRAT D, "Experimental investigation of prechamber autoignition in a natural gas engine for cogeneration", Fuel (2009), pp547-552 ZHANG H, JUCHLI I.,FAVRAT D., PELET X, "Multi-objective thermoeconomic optimisation of the design of heliostats field of solar tower power plants", Taiyangneng Xuebao/Acta Energiae Solaris Sinica (2009), 55-60 FAVRAT D., MARECHAL F., EPELLY O, "The challenge of introducing an exergy indicator in a local law on energy", Energy (2008), pp130-136 HEYNE S.,FAVRAT D et al., "Dev. of a natural gas reaction mechanism for engine simulations based on rapid compression machine experiments using a multi-objective optimisation strategy", Fuel (2008), 3046-3054 AUTISSIER N, PALAZZI F, MARECHAL F, VAN HERLE J., FAVRAT D, "Thermoeconomic optimization of a solid oxide fuel cell, gas turbine hybrid system.", J. of Fuel cell science and technology (2007), 123-129 WEBER C, FAVRAT D, MARECHAL F, KRAINES S , "Design and Optimization of district energy systems", Computer Aided Chemical Eng (2007), pp1127-1132 2007-2009 Awards 2008 SwissElectricResearchAward , Swiss electric 2008-09-05 Prize of CHFrs 25’000, rewarding Jurg Schiffmann for his thesis entitled:integrated design, optimisation and experimental investigation of a direct driven turbocompressor for domestic heat pumps

Audit 2009 - Vol. C Activity Report

School of Engineering

Research Interests Thermodynamics and systemic analyses in environomics (a contraction of energy, environment and economics). Simulation and optimization of complex energy systems including exergy and process integration analyses. Design of advanced equipment for a more rational use of energy: - Heat pumps and organic Rankine cycles including compressors and turbines - SOFC fuel cells and hybrid SOFC-Gas turbine systems - Thermal power plants including geothermal and solar - Internal combustion engines

Current Group 2 Senior Scientists 2 Postdoctoral Fellows 1.3 Administrative Assistants 3 Engineers 2.5 Research Associates 19 PhD Students

The Laboratory for industrial Energy systems(LENI) is structured into 4 groups (systems headed by Dr MER François Marechal, Fuel cells headed by Dr MER Jan Van herle, heat pumps&ORC and Engine)

2007-2009 Patents Rufer A, Favrat D, barrade P et al. , "Hydro-pneumatic storage device for use in power generation and storage system,....": WO2008139267-A1 Favrat D, Weber C, "Carbon dioxide based district heating system for delivering energy services,...": WO2008102292-A2; WO2008102292-A3 Kim Y, Favrat D, Sin D et al. , "Compressed air energy storing electricity generating system for use in building....": WO2008023901-A1 Facchinetti M, Favrat D, Marechal F. , "Sub-atmospheric hybrid cycle SOFC-Gas turbine with CO2 separation": Submitted June 2009 2007-2009 External Grants received at the EPFL total of all grants LENI 2007-2009 OFEN 2007-2009 National Fund 2007 Fischer 2009 CTI 2007-2009 Alstom 2008-2009

CHF 6’490’000 CHF 430’000 CHF 43’000 CHF 171’000 Teaching Activities Bachelor level: Thermodynamics and energy systems I and II 1 bachelor CHF 1’020’000 project team (Mech Eng) CHF 320’000 Master level: Advanced fossil and renewable energy systems (physics), Advanced energetics and engines (Mech Eng), advanced energy conversion technologies (Mech Eng)

Collaborations & Networks Alliance for global sustainability between the Swiss federal Institutes of Technology and MIT, University of Tokyo and Chalmers; Centre Ecleer (European Center and Laboratories for Energy Efficiency Research) with EDF and Ecole des Mines de Paris; Energy department of universities members of Cluster (KTH, Torino, Louvain,...); KIMM (Korean Institute for machine and materials); Numerous compagnies (Alstom, ABB, HTCeramix, Holcim, Fischer Precise, Nestlé,EDF, Veolia, Mistral-engines, Eneftech, Enayris...); World Federation of Engineering Organisations (President of the program committee of the 4th World Engineers Convention in 2011)

Audit 2009 - Vol. C

PhD level: Advanced energy conversion technologies (EY-T01) and Modeling, Optimisation, design and analysis of integrated energy technologies (EY-T02) at present: 11 PhD students being supervised or co-supervised & 8 MS students (2007-2009)

Activity Report

School of Engineering

React Group Denis Gillet, Senior Scientist President of STI IT Committee Denis Gillet received the Diploma (MS) in Electrical Engineering from the Swiss Federal Institute of Technology in Lausanne (EPFL) in 1988, and the Ph.D. degree in Information Systems also from the EPFL in 1995. During 1992 he was appointed as Research Fellow at the Information Systems Laboratory of Stanford University in the United States. He is currently MER at the EPFL School of Engineering, where he leads the React multi-disciplinary research group. During the academic year 2005-2006 he was on sabbatical at the Chinese University of Hong Kong. Dr. Gillet is an Executive of the STELLAR European Network of Excellence in Technology Enhanced Learning. He is Associate Editor of the IEEE Transactions on Learning Technoloigies (TLT) and of the International Journal of Technology Enhanced Learning. Keywords: HCI, eLearning, Coordination, Control. http://interaction.epfl.ch/

2007-2009 Significant Publications H. Vargas, J. Sánchez Moreno, C. Salzmann, F. Esquembre, S. Dormido, and D. Gillet, “Web-Enabled Remote Scientific Environments”, Computing in Science & Engineering (May-June, 2009), 36-46 C. Salzmann, D. Gillet, and P. Mullhaupt, “End-to-end adaptation scheme for ubiquitous remote experimentation”, Personal and Ubiquitous Computing (March, 2009), 181-196 D. Perritaz, C. Salzmann, D. Gillet, O. Naef, J. Bapst, F. Barras, E. Mugellini, and O. Abou Khaled, “6th Sense - Toward a Generic Framework for End-to-End Adaptive Wearable Augmented Reality”, Lecture Notes In Computer Science (March, 2009), 280-310 S. El Helou, D. Gillet, Ch. Salzmann, and Y. Rekik, “Social Software for Sustaining Interaction, Collaboration, and Learning in Communities of Practice”, Advances in Web-Based Learning Book Series (2009), 300-316 S. El Helou, D. Gillet, C. Salzmann, Y. Rekik, “Feed-oriented awareness services for e-logbook mobile users”, International Journal of Mobile Learning and Organisation (2008), 305-317 C. Salzmann and D. Gillet, “From online experiments to smart devices”, International Journal of Online Engineering (2008), 50-54 H. Vargas, J. Sanchez, N. Duro, R. Dormido, S. Dormido-Canto, G. Farias, S. Dormido, F. Esquembre, Ch. Salzmann, and D. Gillet, “A Systematic Two-Layer Approach to Develop Web-based Experimentation Environments for Control Engineering Education”, Intelligent Automation and Soft Computing (2008), 505-524 Y. Rekik, D. Gillet, S. El Helou, and C. Salzmann, “The eLogbook Framework: Sustaining Interaction, Collaboration, and Learning in Laboratory-Oriented CoPs”, International Journal of Web-based Learning and Teaching Technologies (2007), 61-76

Audit 2009 - Vol. C Activity Report

School of Engineering

Research Interests Current Group The undertaken interdisciplinary research aims at handling real-time coordination and distributed interaction 1/3 Postdoctoral Fellow challenges using systems engineering methodologies. The underlying approach is to exploit in an integrated 5 PhD Students manner the dynamical couplings that exist between users, distributed physical systems, as well as information systems (including network) to improve the quality of services and the quality of experience. In this framework, the main research topics are currently Optimal Coordination Systems and Web-based Interaction Systems. The current focus in Optimal Coordination Systems is on metrics and structures definition for the real-time operation of distributed devices where the dynamics matters, with application to autonomous transportation systems, insulin delivery for the treatment of diabetes, as well as teleoperation and supervision of mechatronic systems. The underlying academic domains are Distributed Control, Hierarchical Control, and Telematics. The current focus in Web-based Interaction Systems is on personal learning environments and contextual recommender systems where utility, usability and appropriation matter, with application to on-line engineering education and knowledge management. The underlying academic domains are Human Computer Interaction (HCI), Engineering Education Research, and Technology Enhanced Learning (e-Learning).

2007-2009 External Grants received at the EPFL SNCF - FINES - ESO-PRIMA 01.2004 - 08.2008

CHF 273’000

Roche Disetronic Medical Systems 04.2009 - 03.2010

CHF 130’000

Hasler Foundation - 6th Sense 10.2005 - 07.2010

CHF 244’000

EU FP7 IST - STELLAR NoE 02.2009 - 05.2012

CHF 431’000

EU FP7 IST - ROLE IP 02.2009 - 01.2013

CHF 681’000

EU FP6 IST - ProLEARN NoE 01.2004 - 12.2007

CHF 267’000

EU FP6 IST - PALETTE IP 02.2006 - 01.2009

CHF 350’000

EPFL - FIFO - Autonomy 2.0 09.2007 - 08.2009

CHF 140’000

Collaborations & Networks Executive of the STELLAR European Network of Excellence in Technology Enhanced Learning (TEL).

Teaching Activities Bachelor Course: Automatic Control Hands-on Laboratory Sessions, EPFL, for students in EE, ME and MT.

Coordinator of the Joint European Doctoral School on TEL.

Master Course: Multivariables Systems, EPFL, for students in EE, ME and MT.

Member IFAC Technical Committee on Control Education. General Chair and IPC Chair for the 2010 International Workshop on Internet-based Control Education. Associate Editor of the IEEE Transactions on Learning Technoloigies (TLT). Associate Editor of the International Journal of Technology Enhanced Learning.

Doctoral Course: Human-Computer Interaction issues in TEL, Joint European Doctoral School on TEL. Master Students (20): Twenty between 2007 and 2009. PhD Students (11): Five past (as main PhD Director), Five current (ditto), One starting in January 2010.

Member of Scientific Advisory Board, International Association of Online Engineering. Member of the International Steering Committee, International Network for Engineering Education and Research.

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Activity Report

School of Engineering

Mechnical Systems Design Laboratory Jacques Giovanola, Full Professor Dean Doctoral School Diplôme d’ingénieur mécanicien EPFL (1976). PhD in ME UC Berkeley (1980): The J-Integral as a Fracture Parameter. Research Engineer then Program Manager, SRI International, Menlo Park, USA (1980-96). Fundamental and applied research in structural and materials dynamics and fracture for government agencies (AFOSR, ARO, NSWC) and private companies (ISUZU, Komatsu, Daikin, United Technologies, IRSID). Full Professor EPFL (1997-today). Since 01/2006 Dean of Doctoral School. Born 1950; married 2 children; Swiss/US citizen Keywords: Fracture mechanics, Manufacturing processes, Dynamics and vibrations, Mechatronics http://lcsm.epfl.ch/

2007-2009 Significant Publications Cannizzaro D, Rossoll A, Giovanola J H and Doglione R., “Criterion for Ductile Void Nucleation at Hard Tightly Bonded Particles for Arbitrary Stress States", Eng. Fract. Mech. (2009), to be submitted

2007-2009 External Grants received at the EPFL Private Sector 2007-2009

CHF 550’000

FNS 2007-2009

CHF 150’000

Benoit M, Giovanola JH, Curnier A, Agbeviade K, Donnet M., “Characterization of pressure wave propagation in biological tissues”, Dymat 2009 Proc. (2009),

CTI 2007-2009

CHF 1’020’000

Jodlowski T, Giovanola JH., “Mechanics of Growth and Coalescence of Preexisting Voids”, ICF 12 Proc. (2009), Cannizzaro D, Rossoll A, Giovanola JH, Doglione R., “Numerical Investigation of Nucleation and Stability of Voids at Small Hard Tightly Bonded Particles”, Eng. Fract. Mech. (2009), in preparation Pouvreau C, Wasmer K, Breguet JM, Michler J, Schulz D, Giovanola JH., “Indentation Cracking in Gallium Arsenide: Part I in-situ SEM indentation", Adv. Eng. Mat. (2009), in preparation Caligiuri, R. D., Eiselstein, L. E., Schmidt, C. G., and Giovanola, J. H, “Stable Deformation at Very High Strain Rates in UHCS”, International Journal of Microstructure and Materials Properties (2008), 3/591-606 Hoover, D. and Kremer, D, “Milli Newton Force Measurement and Control for Micro Ultrasonic Machining ”, ISEM Proc. (2007), 2007-2009 Patents Benoit, M., Agbebeviade, K. and Donnet, M, “Instrument zur Behandlung von biologischem Gewebe, sowie Verfahren zum Erzeugen von stosswellenartigen Druckwellen in einem solchen Instrument”: EP08168076

Collaborations & Networks Network CTI expert CRUS Prodoc evaluation team Swiss Universities representative Sciex-NMS Steering Committee EPFL representative Swissmem Research Committee Manufuture-CH Steering Committee and representative at EU level in NRTP group. Member of the Swiss delegation to the Intelligent Manufacturing System Association Collaborations EMPA Thun (Dr. K. Wasmer) Université Catholique de Louvain (Prof. T. Pardoen) Politecnico Torino (Prof. R. Doglione) ENSAM-Cluny (Dr. Fromentin) SRI International (Dr. Shockey) Teaching Activities BA Introduction au Génie Mécanique I & II (S1 & 2) Systèmes mécaniques (S3) Méthodes de conception I & II (S4 & 5) Projet de conception (S5) Techniques de mesure, 1 TP (s6) MS Systèmes mécatroniques I & II (S7 & 8) Conception mécanique I & II (S7 & 8) EDOC Modeling and Simulation of Manufacturing Processes

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School of Engineering

Research Interests Micromechanical characterization and modeling of ductile and brittle fracture processes. Characterization and modeling of non-conventional manufacturing processes (high-speed micromilling of metals, ultrasonic machining of glass and ceramics). Wave propagation in biological tissues. Shock and vibration response of materials and structures. Design methodologies.

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Activity Report

Current Group 1 Scientist 1 Group Leader 1 Postdoctoral Fellow 2 Scientific Collaborators 4 PhD Students 2 Engineers 0.5 Administrative Assistant 2 Master Students 2 Internship Students 1 Student Assistant

School of Engineering

ÂŠ EPFL 2009

Laboratory for Production Management and Processes Rémy Glardon, Full Professor Director of Mechanical Engineering Section Prof. Rémy Glardon mini-biography. Born 1950 in Switzerland. 1973 Ms Mechanical Engineering, EPFL. 1977 Phd Materials Science, EPFL. 1979-1982 Postdoc UC Berkeley, Mechanical Engineering. 1982-1995 Various managerial positions in industry in R&D, production management, logistics and operations management. Last position: Operations Manager, member of the board of director, Portescap international company. From Sept. 1995 Professor at the Swiss Federal Institute of Technology at Lausanne. Director of the Institute for Design, Analysis & Production of Mechanical Systems (ICAP), Director of the Laboratory for Production Management & Processes (LGPP), Director of the Mechanical Engineering Section. Membership and Services. Vice-President and member of the board of the Manufuture-CH Association and R&D-Consortium Member of the steering committee of the CTI-program ’’Production & Logistics (1997-2000) CO-founder and member of the Steering Committee of the HTO (Human-Technology-Organization) Swiss network Associate member of the CIRRELT research centre, Canada Member of the Foundation committee of the Invention Space¨, Lausanne, Switzerland (represents EPFL) Member of ASME, ASM, APICS Keywords: Supply Chain Magagement, Selective Laser Sintering. http://lgpp.epfl.ch/

2007-2009 Significant Publications G. PÉPIOT, N. CHEIKHROUHOU, J.-M.FUERBRINGER, R. GLARDON, “A fuzzy approach for the evaluation of competences”, International Journal of Production Economics (March 2008), 2008, pp 336-353 G. PÉPIOT, N. CHEIKHROUHOU, J.-M. FÜRBRINGER, R. GLARDON, “UECML: Unified Enterprise Competence Modelling Language”, Computers in Industry (Feb. 2007 ), 130-142. N. CHEIKHROUHOU, C. HACHEN, R. GLARDON, “A Markovian Model for the Hybrid Manufacturing Planning and Control Method ‘Double Speed Single Production Line’ ”, Computers & Industrial Engineering (2009), in press N. CHEIKHROUHOU, G. PIOT, M. POULY , “A multicriteria model for the evaluation of business benefits in horizontal collaborative networks”, Journal of Intelligent Manufacturing (2009), in press J. JHABVALA, M. DAFFLON, E. BOILLAT, R. GLARDON, “Influence of the process parameters on the liquid bridges between particles in SLS”, In P. J. Bártolo et al., editor, Virtual ad Rapid Manufacturing, Advanced Research in Virtual and Rapid Prototyping, Taylor and Francis (2007), 553-558 A. WINDISCHER, G. GROTE, F. MATHIER, S. MEUNIER MARTINS, R. GLARDON, “Characteristics and organizational constraints of collaborative planning”, Cognition Technology & Work (11(2009)87), 11(2009)87 2007-2009 Awards Best Paper Award, CSCWD’09: 13th International Conference on Computer Supported Cooperative Work in Design. 2009-04-25 Using the Generic Product Model for storing and sharing ERP dataNaciri S.; Pouly M.; Binggeli J.-C.; Glardon R.

Audit 2009 - Vol. C Activity Report

School of Engineering

Research Interests The Laboratory for Production Management & Processes develops its research activities in the two following areas: 1) Operations & Supply Chain Management 2) Layer manufacturing processes through Selecctive Laser Sintering Operations & Supply Chain Management The objectives of the research is to develop models and tools that lead to a better understanding of the behavior of complex Value Adding Network (VAN). This should ultimetaly lead to a more rigorous procedure for performance improvement of networked manufacturing and service enterprises.

Current Group 2 Group Leaders 1.5 Senior Scientists 3 Engineers 4 PhD Students (external) 1 Research Associate 2 Internship Students

The main topics of interest are modelling & simulation of VANs, integration of human decision making in Supply Chain Management, collaborative planning & control, competence modelling & management, physical internet Layer manufacturing processes through Selective Laser Sintering The objectives of the research are on the one hand to improve the understanding of the physical phenomena that govern the Selective Laser Sintering (SLS) process and on the other hand to improve its performances in terms of strength and surface quality. The main topics of interest are the modelling of the physical phenomena governing the SLS-process, the improvement of the process performance and its application to specific materials.

Collaborations & Networks CIRRELT, Interuniversity Research Center on Enterprise Networks, Logistics and Transportation, Canada Teaching Activities BA, Title, Level, Volume, [h] Glardon, Boillat,Procédés de production, BA 6 28 Ramseyer, Statique, BA 2 28 Ramseyer, Introduction au Génie mécanique I BA 1 28 Ramseyer, Introduction au Génie mécanique II BA 2 42 Ramseyer, Projets de conception BA 5 56

2007-2009 External Grants received at the EPFL INTERREG 2007 IMS 2008 Givaudan 2008 EUREKA 2007 CTI 2009 CTI 2007 CTI 2008 Cartier- Horlogerie 2007

CHF 85’000

MA, Title, Level, Volume, [h] Glardon, Gestion de production I, MA 1 28 Glardon, Gestion de production II, MA 2 28 Glardon, Hongler, Wieser Supply Chain Management, MA 2 42 Boillat, Méthodes de développement et de production rapides MA1 28 Cheikhrouhou, Modélisation &simulation de systèmes de production MA 2 28 Pouly, Conception de systèmes de production, MA 1, 28

PhD, Title, Level, Volume [h] CHF 91’000 Boillat, Modeling and simulation of manufacturing processes, PhDPR006 14 CHF 30’000 Fürbringer, Design of Experiment, PhD-PR 02, 40 Cheikhrouhou, Planning and control of value adding networks under CHF 232’000 uncertainties, PhD-PR 003 28 CHF 348’000 Others, Program, Institution, Title, Volume [h] Glardon, IML, Production Systems, 35 CHF 210’000 Glardon, IML, Operational SCM, 35 Glardon, Tactical, SCM, 35 CHF 89’000 Glardon, Cheikhrouhou, Pouly, IML-ASL, Gestion de production, 6 Boillat, Matthey, FSRM, Technologies for Rapid Tooling, 8. CHF 478’660

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Activity Report

School of Engineering

Group Gmür Thomas Gmür, Adjunct Professor Thomas Gmür is Professor of structural dynamics and identification at the Laboratory of Applied Mechanics and Reliability Analysis (LMAF) of the ETH Lausanne since 2006. Born in Brussels (Belgium) in 1954, he studied Mechanical Engineering at the ETH Lausanne where he received his MS degree in 1978 and his PhD degree in 1982. Senior engineer and later on project manager, he became leader of the structural dynamics group in 1986. His research work was focusing on the development of numerical algorithms and experimental tools in structural dynamics and on the formulation of finite element models. Since 1996, his scientific activities also include the modal analysis of multilayered and sandwich composite structures, and more specifically the experimental-numerical parameter characterization in such components. His research team is closely working together with national and international research institutes and industries, seeking a well-balanced project portfolio of fundamental and applied projects. Thomas Gmür has authored or co-authored more than 60 peer-reviewed publications or conference papers, and 5 books or book chapter as well. He is also co-founder of the start-up NRCTech at Ecublens in 2002. Since 1979, he is lecturer at the Section of Mechanical Engineering at the ETH Lausanne and his teaching experience covers currently computational mechanics, structural dynamics and mechanical vibrations. His teaching activity was awarded in 2007 with the Crédit Suisse Prize for Best Teaching. Keywords: Structural Dynamics, Modal Identification, Characterization of Constitutive Parameters, Numerical Methods, Finite Element Method, Mechanics of Composites. http://lmaf.epfl.ch/

2007-2009 Significant Publications Matter M., Gmür Th., Cugnoni J., Schorderet A., “Numerical-experimental identification of the elastic and damping properties in composite plates”, Compos Struct (2009), 90, 180-187 Prenleloup A., Gmür Th., Botsis J., Papailiou K. O., Obrist K., “Stress and failure analysis of crimped metal-composite joints used in electrical insulators subjected to bending”, Compos A (2009), 40, 644-652 Sorensen L., Botsis J., Gmür Th., Humbert L., “Bridging tractions in mode-I delamination: measurements & simulations”, Compos Sci Technol (2008), 68, 2350-2358 Sulmoni M., Gmür Th., Cugnoni J., Matter M., “Modal validation of sandwich shell finite elements based upon a p-order shear deformation theory including zigzag terms”, Int J Numer Meth Eng (2007), 75, 1301-1319 Sorensen L., Botsis J., Gmür Th., Cugnoni J., “Delamination detection and characterisation of bridging tractions using long FBG optical sensors”, Compos A (2007), 38, 2087-2096 Matter M., Gmür Th., Cugnoni J. and Schorderet A. , “Improved modal characterization of the constitutive parameters in multilayered plates”, Compos Sci Technol (2007), 67, 1121-1131 Cugnoni J., Gmür Th., Schorderet A., “Inverse method based on modal analysis for characterizing the constitutive properties of thick composite plates”, Comp Struct (2007), 85, 1310-1320

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School of Engineering

Research Interests Current Group The research objective of the structural dynamics group is the development, analysis and optimisation of 1 PhD Student lightweight and smart structures made of composite material and subjected to vibrations and/or impact 1 Engineer loads. This firstly includes the development of new finite element plate and shell models and novel modal mixed numerical-experimental identification methods for characterizing the elastic and damping properties in composite mechanical components or systems and for estimating the changes of these parameters when the structure is subject to continuous degradation by natural ageing like ultraviolet radiation, moisture and chemical or thermal aggressions. The second focal point is the computational and experimental structural analysis of composite plates and shells under low impact loading and/or modal dynamics using innovative embedded or patched sensors and/or actuators like optical fibre gratings or piezoelectric films. The expertise built with the fundamental research on composite structures has been applied in several industrial cases such as mixed metal-composite adhesively bonded or crimped joints or ultralight high-performance sandwich structures like snowboards and skis. The structural dynamics group has provided a number of valuable contributions in internationally recognised refereed journals and its activity gave rise to many PhD theses in the field of design, analysis, simulation, testing, characterization and optimisation of composite structures.

2007-2009 Awards CreditSuisse Award for Best Teaching, EPFL 2007-04-01

Collaborations & Networks Within EPFL Best EPFL teacher in 2007 LCSM, LTC, LOA, LSRO, LME, LEMA, LPN, SpaceCenter, ...

SNF 2007–2009

Ouside EPFL Universidade do Porto (P), Pfisterer (D), Sintetica (CH), Nidecker (CH), CHF 238’128 PDE Automotive (NL), NRCTech (CH), Hydroptère (CH), Alinghi (CH), CERN (EU), ... CHF 224’750

SNF 2009-2011

CHF 217’155 Teaching Activities

CTI/Sintetica 2007–2009

CHF 333’170 Courses given in 2008-2009

CTI/Pfisterer 2004–2007

CHF 623’500 Mechanics of Vibrations, mandatory BS course, 4 ECTS, 51 students, evaluation grade 5.2 CHF 684’850 Finite Element method, mandatory BS course, 3 ECTS, 52 students, evalutation grade 5.2

2007-2009 External Grants received at the EPFL SNF 2004–2008

CTI/Nidecker 2005–2008

Computational Methods in Solids and Structures, optional MS course, 3 ECTS, 17 students, evaluation grade 5.4 Master projects supervised Diploma works (53 in total), 2 in 2007, 4 in 2008, 6 in 2009 Semester projects (119 in total), 4 in 2007, 7 in 2008, 7 in 2009 Other teaching activities for the Section of Mechanical Engineering Board member, Member of the Teaching Commission, Delegate for the student exchanges, Student Advisor for the Solids and Structures orientation

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School of Engineering

Group Karimi Alireza Karimi, Senior Scientist Alireza Karimi received his B. Sc. and M. Sc. degrees in Electrical Engineering in 1987 and 1990 from Amir Kabir University (Tehran Polytechnic). From 1990 to 1993 he was in charge of Automation Section in Iran-Switch and SAPTA companies. Then he received his DEA and Ph. D. degrees both on Automatic Control from Institut National Polytechnique de Grenoble (INPG) in 1994 and 1997. He was Assistant Professor at Electrical Engineering Department of Sharif University of Technology in Teheran from 1998 to 2000. Then he joined Automatic Laboratory of Swiss Federal Institute of Technology at Lausanne, Switzerland. He is currently Associate Editor of European Journal of Control. Keywords: Data-driven controller tuning, System identification, Robust control. http://lawww.epfl.ch/

2007-2009 Significant Publications Miskovic, Ljubisa ; Karimi, Alireza ; Bonvin, Dominique ; Gevers, Michel , “Closed-loop Identification of Multivariable Systems: With or Without Excitation of All References?”, Automatica (2008), vol. 44, num. 8, p. 2048-2056 Karimi, Alireza ; Butcher, Mark ; Longchamp, Roland, “Model-Free Precompensator Tuning Based on the Correlation Approach”, IEEE Transactions on Control Systems Technology (2008), vol. 16, num. 5, p. 1013-1020 Khatibi, Hamid ; Karimi, Alireza ; Longchamp, Roland , “Fixed-Order Controller Design for Systems with Polytopic Uncertainty Using LMIs”, IEEE Transactions on Automatic Control (2008), vol. 53, num. 1, p. 428-434 Butcher, Mark ; Karimi, Alireza ; Longchamp, Roland, “A Statistical Analysis of Certain Iterative Learning Control Algorithms”, International Journal of Control (2008), vol. 81, num. 1, p. 156-166 Karimi, Alireza ; Khatibi, Hamid ; Longchamp, Roland, “Robust Control of Polytopic Systems by Convex Optimization”, Automatica (2007), vol. 43, num. 6 p. 1395-1402 Miskovic, Ljubisa ; Karimi, Alireza ; Bonvin, Dominique ; Gevers, Michel, “Correlation-Based Tuning of Decoupling Multivariable Controllers”, Automatica (2007), vol. 43, num. 9, p. 1481-1494 Karimi, Alireza ; Kunze, Marc ; Longchamp, Roland, “Robust Controller Design by Linear Programming with Application to a Double-Axis Positioning System”, Control Engineering Practice (2007), vol. 15, num. 2, p. 197-208 Garcia, Daniel ; Karimi, Alireza ; Longchamp, Roland, "Robust PID controller tuning with specifications on the infinitynorm of sensitivity functions", IEE Proceedings Control Theory and Applications (2007), vol. 1, num. 1, p. 263-272.

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School of Engineering

Research Interests The research objective of this group is mainly to develop new methodologies for computing robust controllers for linear systems using only the experimental data. Data-driven model-free controller-tuning approaches try to lump the identification, controller design and controller reduction together and present a direct “datato-controller’’ algorithm. Many nonlinear systems can be presented by a set of linear models or as LinearParameter-Varying systems. Developing data-driven methods for such systems using the convex optimization approaches is also among the main research axis of this group. The proposed method are applied to high precision mechatronic systems, but the other applications can also be considered.

2007-2009 External Grants received at the EPFL FNS 2008-2011

CHF 148’725

FNS 2005-2008

CHF 127’889

FNS 2007-2009

CHF 94’606

FNS 2005-2008

CHF 126’389

Collaborations & Networks - Member of doctoral programme committee in Manufacturing Systems and Robotics (EPFL) - Member of Teaching Committee in SGM (EPFL) - Member of IEEE Technical Committee on System Identification and Adaptive Control - Associate Editor of European Journal of Control since 2004 Teaching Activities - System Identification (Master course, 3 credits) - Advanced Control (Master course, 3 credits, in collaboration) - Robust Control (Doctoral course, 4 credits, in 2005 and 2007) - Estimation Theory (Doctoral course, 4 credits, planned 2010-2011) - 7 Phd students (currently 3) - Supervising Master projects

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Activity Report

School of Engineering

Automatic Control Laboratory 2 Roland Longchamp, Full Professor Roland Longchamp is Professor of Automatic Control and Director of the Automatic Control Laboratory at EPFL. He received his Diploma in Electrical Engineering and his Ph.D. degree both from EPFL. He was appointed as Postdoctoral Fellow, first at the Information Systems Laboratory, Stanford University, and then at the Decision and Control Laboratory, University of Illinois at Urbana-Champaign, working in the areas of nonlinear systems, estimation theory and predictive control. He was with the Asea Brown Boveri Company in Turgi, Switzerland, involved in the field of on-line control of large power systems. He joined EPFL in 1983, where his current research interests include control of linear systems, adaptive control, robust control, with applications to mechatronic systems. He served as Head of the Mechanical Engineering Department in 1991-1993 and as Director of the Automatic Control Laboratory for the periods 1986-1993 and 1997-2003. He is Editor of the EPFL Press Mechanical Engineering Series since 1996. Keywords: Adaptive control, robust control, control systems in mechatronics. http://lawww.epfl.ch/

2007-2009 Significant Publications A. Karimi, M. Butcher, and R. Longchamp, “Model-Free Precompensator Tuning Based on the Correlation Approach”, IEEE Transactions on Control Systems Technology (2008), vol. 16, numb. 5, 1013-1020 H. Khatibi, A. Karimi, and R. Longchamp, “Fixed-Order Controller Design for Systems with Polytopic Uncertainty Using LMIs”, IEEE Transactions on Automatic Control (2008), vol. 53, numb. 1, 428-434 M. Butcher, A. Karimi, and R. Longchamp, “A Statistical Analysis of Certain Iterative Learning Control Algorithms”, International Journal of Control (2008), vol. 81, numb. 1, 156-166 A. Karimi, H. Khatibi, and R. Longchamp, “Robust Control of Polytopic Systems by Convex Optimization”, Automatica (2007), vol. 43, numb. 6, 1395-1402 A. Karimi, M. Kunze, and R. Longchamp, “Robust Controller Design by Linear Programming with Application to a Double-Axis Positioning System”, Control Engineering Practice (2007), vol. 15, numb. 2, 197-208 D. Garcia, A. Karimi, and R. Longchamp, “Robust PID Controller Tuning with Specifications on the Infinity-Norm of Sensitivity Functions”, IEE Proceedings Control Theory and Applications (2007), vol. 1, numb. 1, 263-272.

Audit 2009 - Vol. C Activity Report

School of Engineering

Research Interests Control of linear systems. Adaptive control. Robust control. Control of mechatronic systems.

2007-2009 External Grants received at the EPFL SNSF 2008-2011

Current Group 1 Senior Scientist 1.95 Scientists 0.5 Technician 0.65 Administrative Assistant 0.5 Trainee 7 PhD Students

CHF 149’000

SNSF 2008-2009

CHF 69’000

SNSF 2007-2009

CHF 95’000

SNF 2005-2008

CHF 126’000

CTI 2004-2006

CHF 297’000

Collaborations & Networks Director of the Automatic Control Laboratory Editor of the EPFL Press Mechanical Engineering Series Member of the Electrical Engineering Doctoral Program Committee Member of the the EPFL Libraries Committee (COB) Teaching Activities Automatic Control I (mandatory bachelor course for students in EE, ME, and MT) Automatic Control II (mandatory bachelor course for students in EE and MT, elective course for students in ME) Advanced Control (elective master course for students in EE, ME, and MT) 11 master students in last 3 years 21 Ph.D. students (currently 3)

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School of Engineering

Groupe Maréchal François Maréchal, Senior Scientist Belgium: 28.05.1963, Married: 3 Children, 1986: Chem. Eng., ULg (Liège,B) 1995 : PhD. ULg. (prof. Kalitventzeff lab) : “Energy analysis and synthesis of Industrial Processes» 2001 : EPFL, Industrial Energy Systems Laboratory 2005 : EPFL : Senior Scientist. Keywords: Process system engineering, process integration, energy efficiency, Energy conversion, Urban systems. leni.epfl.ch

2007-2009 Significant Publications Girardin et al., “EnerGis : A geographical information based system for the evaluation of integrated energy conversion systems in urban areas”, Energy (2009), in press Bernier et al., “Multi-objective design optimization of a natural gas-combined cycle with carbon dioxide capture in a life cycle perspective”, Energy (2009), in press Gassner and Marechal , “Methodology for the optimal thermo-economic, multi-objective design of thermochemical fuel production from biomass”, Comp. & Chem. Eng. 33(3) (2009), 769-781 Collazos et al., “Predictive Optimal Management Method for the control of polygeneration systems ”, Comp. & Chem. Eng. 33(10) (2009), 1584-1592 Marechal et al., “Energy Systems Engineering, Invited chapter : Multi-Objective Design and Optimisation of Urban Energy Systems”, ISBN: 978-3-527-31694-6 (2008), 39-81 Gassner and Marechal , “Thermo-economic optimisation of the integration of electrolysis in synthetic natural gas production from wood”, Energy (33) (2008), 189-198 Vince et al., “Multi-objective optimization of RO desalination plants, Desalination”, Desalination, 222 (2008), 96-118 Muller et al., “An energy management method for the food industry”, Applied Thermal Engineering (7) (2007), 471-476

Audit 2009 - Vol. C Activity Report

School of Engineering

Current Group Research Interests Our goal is to develop process system engineering methods for the analysis and the synthesis of efficient and 1 Senior Scientist 7 PhD Students more sustainable thermo-chemical processes. 2 Research Assistants We develop process integration and conceptual process system design methods based on process modeling 1 Postdoctoral Fellow and optimization techniques for studying the rational use and conversion of energy and water in industrial processes and for reducing their environmental impact. Such methods are applied in the food and chemical industry and in energy conversion processes like power plants with CO2 capture, biofuels production, fuel cell systems, geothermal plants, waste water treatment, desalination, ...Applying process system engineering techniques, we study the design of industrial ecology concepts in urban areas by realising the large scale integration of energy systems using networks (heating, cooling, hydrogen, water, CO2,...), considering simultaneously the available (renewable) energy resources, the industrial processes and the buildings requirements.

2007-2009 External Grants received at the EPFL VEOLIA (3 projects) 2005-2009

CHF 328’181

Swisselectric 2008-2011

CHF 120’812

OFEN (5 projects) 2005-2008

CHF 664’000

NESTLE 2003-2007

CHF 341’000

FNS : (2 projects) 2005-2010

CHF 393’233

European commission 2006-2012

CHF 414’188

Erdgas Ost Schweiss 2007-2010

CHF 126’000

EDF (2 projects) 2008-2012

CHF 475’000

Cities and cantons (5 projects) 2005-2011

CHF 262’184

CCEM-CCES (4 projects) 2007-2012

CHF 481’380

Alstom (1 project) 2009-2012

CHF 280’000

Collaborations & Networks - European Center and Laboratories for Energy Efficiency Research : Join Laboratory with EDF and Ecole des Mines Paris (F) - Competence Center Energy Mobility and Environment and Sustainability : PSI, EMPA, ETHZ, FHNW, industry - Biofuels: CEA (F), CORNEL (USA), UNICAMP (Br) - Energy and water efficiency in industry : Nestle (CH), Rhodia (F), EDF (F), VEOLIA (F),Polytechnique de Montreal (CAN), Syngenta (CH) - Swiss representative working party on Computer Aided Process Engineering of the European Federation of Chemical Engineering

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Teaching Activities Coordination of the Minor in Energy (STI-EPFL) Master program Modeling and optimization of energy conversion systems (SGM: 4 ECTS); Advanced energetics (SGM: 5 ECTS); Energy conversion (SIE SMX: 2 ECST); Thermal power plants(SEL: 1 ECST) Doctoral school, energy program Advanced Energy Conversion Systems 2ECTS (4 prof.), Modelling, Optimisation, Design and Analysis of Integrated Energy Technologies 2 ECTS (2 prof.) Invited Professor at the Renewable Energy Sciences School (Iceland) Student projects (67 master thesis since 2001)

Activity Report

School of Engineering

Fluid Mechanics Laboratory Peter Monkewitz, Full Professor After graduating in physics from the Swiss Federal Institute of Technology in Zurich, he received his Ph.D. from the same institution in 1977 with a thesis on internal acoustics. After a post-doc in the Aerospace Department of the Univ. of Southern California in Los Angeles he joined the faculty of the School of Engineering at UCLA in 1980. In 1988 he was awarded the Humboldt prize and spent the academic year 1989/90 as Humboldt Prize recipient at the Technical University in Berlin. In 1992 he was elected Fellow of the American Physical Society. From 1993 until February 2009 he held the chair for experimental fluid mechanics and headed the Laboratory of Fluid Mechanics (LMF) of the Swiss Federal Institute of Technology in Lausanne (EPFL), Switzerland. He has also held visiting appointments at DLR, the University of Marseille, the Illinois Institute of Technology in Chicago and the University of Melbourne. He has organized the 6th European Turbulence Conference at EPFL in 1996, has been Chairman of its Mechanical Engineering Department from July 1997 to December 2000, co-organizer of the 1999 “Research programme on turbulence” at the Isaac Newton Institute in Cambridge, Associate Editor of the Journal of Fluid Mechanics from 1995 to 2000, “Research Councilor” (= program monitor) at the Swiss National Science Foundation from 1997 to 2006 and a member of the EUROMECH Council. He is currently an Associate Editor of Physics of Fluids, remains one of the two Swiss representatives in IUTAM and is a member of an ERC panel of the European Union. Prof. Monkewitz retired in 2009, and is now an Honorary Professor. Keywords: Hydrodynamic Instabilities, Combustion instabilities, Transition to turbulence, Turbulent flows and mixing, Tunnel aerodynamics, Acoustics. http://lmf.epfl.ch

2007-2009 Significant Publications Robert, E. and Monkewitz, P.A., “Experiments in a novel quasi-1D diffusion flame with variable bulk flow”, Proc. Combust. Inst. (2009), vol. 32 Monkewitz, P.A., Chauhan, K.A. and Nagib, H.M., “Comparison of mean flow similarity in zero pressure gradient turbulent boundary layers”, Phys. Fluids (2008), vol. 20, 105102 Monkewitz, P.A., Chauhan, K.A. and Nagib, H.M., “Self-consistent high-Reynolds number asymptotics for ZPG turbulent boundary layers”, Phys. Fluids (2007), vol. 19, 115101 4. LoJacono, D. and Monkewitz, P.A., “Scaling of cell size in cellular instabilities of nonpremixed jet flames”, Combustion and Flame (2007), vol. 151, 321-332 Nagib, H.M., Chauhan, K.A. and Monkewitz, P.A., “Approach to an asymptotic state for zero pressure gradient turbulent boundary layers”, Phil. Trans. Roy. Soc. (2007), vol. A 365, 755-770

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School of Engineering

Research Interests Hydrodynamic instability, bluff body wake flows, turbulence and early on acoustics approached both theoretically and experimentally. In the field of hydrodynamic instability he had a hand in the popularization of the concept of absolute instability in fluid mechanics, the development of the concept as well as of the asymptotic analytical description of global modes in nonparallel flows. He discovered absolute instability in low density jets and co-discovered enhanced mixing by ‛side-jets’ in such jets. He has further contributed significantly to the theoretical modeling of vortex shedding from bluff bodies. Other areas of research include internal acoustics, flow control and transition to turbulence. The areas of current interest are flame instabilities studied in the first experimental realization of a one-dimensional unstretched diffusion flame, localized 3D global modes in the Rayleigh-Bénard-Poiseuille system, grid turbulence and the asymptotics of turbulent boundary layers.

Collaborations & Networks Close ongoing collaboration on turbulent boundary layers with Prof. Hassan Nagib of IIT Chicago since 2000. Member of a collaboration between IIT (H. Nagib), KTH (H. Alfredsson), Princeton (L.Smits) and the University of Melbourne (I. Marusic) to identify the cause of discrepancies between turbulent boundary layer experiments and establish a more solid basis for theoretical developments. Participation in the CICLOPE project of the University of Bologna to build a large turbulent pipe flow facility with international access near Predappio.

Teaching Activities Until February 2009, incompressible fluid mechanics both for mechanical engineering and physics students, instability and turbulence, experimental techniques, selected topics in fluid mechanics and asymptotic methods at the doctoral level. After my retirement I am so far scheduled to keep teaching asymptotic methods at the doctoral level.

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School of Engineering

Applied Thermodynamics and Thermal Turbomachinery Laboratory Peter Ott, Research Associate May 1st, 1956 Date of birth 1981 Diploma Thesis at University of Stuttgart (Aeronautics) 1991 PhD Thesis at EPFL 1983 - 2002 Research Assistant, then Senior Research Assistant at LTT since 2002 Director ad interim of LTT-EPFL Keywords: aero engines, gas turbines, turbines, compressors, aerodynamics, measuring techniques, aeroelasticity, turbine cooling, heat transfer, flow control by cold plasma. http://lttwww.epfl.ch/

2007-2009 Significant Publications G. Wagner, P. Ott, G. Vogel, S. Naik, “Leading Edge Film Cooling and the Influence of Fan Shaped Holes at Design and Off-Design Conditions”, ASME Turbo Expo 2007, Power for Land, Sea & Air (May 14-17, 2007), Paper GT2007-27715 A. Beretta, F. Rottmeier, P. Ott, “Experimental Investigation of Combined/Simultaneous Gust and Oscillating Turbine Row Unsteady Aerodynamics in Transonic Flow”, 7th European Conference on Turbomachinery (March 5-9, 2007), pp. 1285-1297 E. Colombo, F. Bario, P. Ott, “Experimental Investigations on the Flow Control by Aspiration Bleeds on the Hub of an Axial Compressor Rotor using the Non Rotating Annular Cascade Test Facility”, 8th European Conference on Turbomachinery (March 23-27, 2009), pp. 29-39 M. Jonsson, D. Charbonnier, P. Ott, J. von Wolfersdorf, “Application of the Transient Heater Foil Technique for Heat Transfer and Film Cooling Effectiveness Measurements on a Turbine Vane Endwall”, ASME Turbo Expo 2008, Power for Land, Sea & Air (June 9-13, 2008), Paper GT200850451 D. Charbonnier, P. Ott, M. Jonsson, Th. Köbke, F. Cottier, “Experimental and Numerical Study of the Thermal Performance of a Film Cooled Turbine Platform”, ASME Turbo Expo 2009, Power for Land, Sea & Air (June 8-12, 2009), Paper GT2009-60306 S. Pavon, P. Ott, P. Leyland, J-L. Dorier, Ch. Hollenstein, “Effects of surface dielectric barrier discharges on transonic flows around an airfoil”, 47th AIAA Aerospace Sciences Meeting (January 5-8, 2009), G. Wagner, E. Schneider, J. v. Wolfersdorf, P. Ott, B. Weigand, “Method for Analysis of Showerhead Film Cooling Experiments on Highly Curved Surfaces”, International Journal of Experimental Thermal and Fluid Science (February 2007), pp 381-389 S. Pavon, J-L. Dorier, Ch. Hollenstein, P. Ott, P. Leyland, “Effects of high-speed airflows on a surface dielectric barrier discharge”, Journal of Physics D: Applied Physics 40 (2007), pp 1733-1741.

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School of Engineering

Research Interests The top level objectives of LTT’s research are related to the European aeroengine industry and Swiss gas and steam turbine industry. The main activities aim innovative engine configurations in order to obtain a significant and durable reduction of pollution together with increased engine safety. LTT is well known as one of few research institutions active in the field of aeroelasticity in turbomachines.

Current Group 2 Postdoctoral Fellows 8 PhD Students 1 PhD Student (external) 2 Administrative Assistants

Main research topics are steady state and unsteady aerodynamics (i.e. aeroelasticity, flutter, forced response), heat transfer (turbine blade cooling), novel aero-thermal control systems (i.e. application of surface plasma in order to influence boundary layers and aerodynamic shock interference). These investigations are carried out experimentally in the worldwide known non-rotating annular cascade test facility of LTT, as well in other well equipped and confirmed test facilities. Advanced measurement techniques necessary to carry out high standard measurements are developed and validated before being used for complex geometries. The so obtained experimental results are confirmed and completed by CFD computations using commercial and in-house software. LTT carries out research in close collaboration with experts from universities, research agencies and industry in bilateral projects and within European projects (FP4 to FP7). All projects lead to at least one PhD thesis related to original investigations on new topics and leading to high quality publications in high standard conferences and journals.

2007-2009 Patents S. Pavon, J.-L. Dorier, Chr. Hollenstein, P. Ott, A. Sublet, “Long Lifetime System for the Generation of Surface Plasmas”: PCT/IB2009/050489 2007-2009 External Grants received at the EPFL Swiss National Fund 2006-2008 Swiss National Fund 2009-2012 National Office of Energy (OFEN) 2009-2013 MTU Aero Engines, Germany (Industry) 2007-2009 European Commission 2004-2008 European Commission 2006-2010 European Commission 2008-2012 European Commission 2009-2012

Collaborations & Networks Industry: - Alstom, Baden (Switzerland) - MTU Aeroengines, München (Germany) - Rolls Royce plc, Derby (United Kingdom) - Rolls Royce Deutschland, Dahlewitz (Germany) CHF 117’000 - Snecma, Safran Group, Villaroche (France) - Avio, Torino (Italy) CHF 200’000 - ITP-Group, Madrid (Spain) - Volvo Aero Corporation, Trollhättan (Sweden) CHF 800’000 Academics: CHF 520’000 - inside EPFL: CRPP, LIN - Universität Stuttgart (Germany) CHF 775’000 - Royal Institute of Technology (KTH), Stockholm (Sweden) - University of Oxford (UK) CHF 969’000 - Universität Karlsruhe (Germany) - Ecole Centrale de Lyon (France) CHF 1’579’000 Research Organizations: CHF 592’000 - German Aerospace Center (DLR) (Germany) - ONERA (France) - ERCOFTAC

Teaching Activities Introduction aux turbomachines thermiques (Bachelor level, 2 hours/ week, half semester) Turbomachines thermiques (Master level, 4 hours/week) Méthodes numériques en thermique (Master level, 2 hours/week) (until 2008) Student experimental exercice laboratory Semester works Diploma works Responsible of 9 PhD students

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Networks: - ASME (Swiss section executive committee member) - European Conference of Turbomachinery (Swiss representative in the organization committee) - AIAA (member) - MTU Aeroengines (member of expert croups "Turbine" and “Compressor” - EPFL - Dassault - Snecma - Thales (member of committee of the framework agreement)

Activity Report

School of Engineering

Heat and Mass Transfer Laboratory John Richard Thome, Full Professor Director of Doctoral Program in Energy, Director of the European ERCOFTAC Coordination Centre John R. Thome is professor and director at the Laboratory of Heat and Mass Transfer since 1998, where his primary interests of research are two-phase flow and heat transfer, covering both macro- and microscale heat transfer and also enhanced heat transfer. He received his Ph.D. at Oxford University, England in 1978 and was formerly a professor at Michigan State University. From 1984 to 1998, he managed his own international engineering consulting company. He is the author of four books: Enhanced Boiling Heat Transfer, Taylor & Francis (1990); Convective Boiling and Condensation, 3rd edition, Oxford University Press (1994); Wolverine Engineering Databook III, an annually updated ebook (2004); and Nucleate Boiling on Microstructured Surfaces, (2008). He received the ASME Heat Transfer Division’s Best Paper Award in 1998 for a three-part paper on flow boiling heat transfer published in the Journal of Heat Transfer. He has published more than 100 journal papers since joining the EPFL and is also active in giving international short courses on selected topics in two-phase flow and heat transfer. Publications 126 Total Citations 1355 Hirsch index 20 Keywords: two-phase flow, macro and microscale heat transfer. http://ltcm.epfl.ch/

2007-2009 Significant Publications Cioncolini, A; Thome, JR; Lombardi, C, “Algebraic turbulence modeling in adiabatic gas-liquid annular two-phase flow”, International Journal of Multiphase Flow (2009), 35;580-596 Agostini, B; Revellin, R; Thome, JR, “Elongated bubbles in microchannels: Parts I-II”, International Journal of Multiphase Flow (2008), 34;590-613 Agostini, B; Thome, JR; Fabbri, M, et al., “High heat flux flow boiling in silicon multi-microchannels: Parts I-III”, International Journal of Heat and Mass Transfer (2008), 51;5400-5442 Revellin, R; Thome, JR, “A theoretical model for the prediction of the critical heat flux in heated microchannels”, International Journal of Heat and Mass Transfer (2008), 51;1216-1225 Revellin, R; Haberschill, P; Bonjour, J, et al., “Conditions of liquid film dryout during saturated flow boiling in microchannels”, Chemical Engineering Science (2008), 63;5795-5801 Quiben, JM; Thome, JR, “Flow pattern based two-phase frictional pressure drop model for horizontal tubes: Parts I-II”, International Journal of Heat and Fluid Flow (2007), 28;1049-1072 Roques, JF; Thome, JR, “Falling films on arrays of horizontal tubes with R-134a: Parts I-II”, Heat Transfer Engineering (2007), 28;398-434 Revellin, R; Thome, JR, “A new type of diabatic flow pattern map for boiling heat transfer in microchannels”, Journal of Micromechanics and Microengineering (2007), 17;788-796 2007-2009 Awards J&E Hall Gold Medal, UK Institute of Refrigeration 2008-02-13 For contributions to refrigeration heat transfer. Eurotherm 2008 Prize , Eurotherm 2008-05-18 Awarded to Dr. Revellin for his PhD thesis “Experimental two-phase fluid flow in microchannels” in Thermosciences from 2004-7, supervised by Prof. John Thome.

Audit 2009 - Vol. C Activity Report

School of Engineering

Research Interests The main fields of research at LTCM ‘Heat and Mass Transfer Laboratory’ are: Single and two-phase heat transfer in microchannels; Pool and convective boiling of pure fluids and mixtures; Condensation of pure fluids and mixtures; Falling film evaporation and condensation; Heat transfer augmentation; Two-phase flows and modelling of flow regime transitions; Flow visualization of two-phase phenomena and void fraction measurements with use of laser sheets; and numerical modelling of microscale flows.

2007-2009 External Grants received at the EPFL Fonds National Suisse - NanoTera 2009-2013

CHF 690’902

Fonds National Suisse 2009-2012

CHF 167’775

Fonds National Suisse 2008-2010

CHF 204’211

Falling Film Research Club 2009-2011

CHF 195’810

European Space Agency 2007-2009

CHF 115’686

European Space Agency 2007-2009

CHF 101’973

CTI-IBM/EMBRACO 2008-2010

CHF 457’000

CCEM 2009-2012

CHF 239’840

ASHRAE 2007-2010

CHF 194’782

ABB 2008-2009

CHF 321’000

Current Group 12 PhD Students 1 Senior Scientist 4 Scientists 1 PhD Student (external)

Collaborations & Networks ABB, ASHRAE, Carrier Coorporation, ERCOFTAC, IBM, Trane Company, Wieland-Werke AG., and Wolverine Tube Inc. Teaching Activities M.Sc./B.Sc. Course: Heat and mass transfer (ME-341) M.Sc./B.Sc. Course: Two-phase flows and heat transfer (ME-446) Doctoral Course: Two-phase flow and Transitions (ME-743) International Short Course: Fundamentals of Microscale Heat Transfer

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Activity Report

School of Engineering

Group Van Herle Jan Van Herle, Senior Scientist 1987 : Chemist from Basel University (CH). 1988 : Post-graduate IT diploma from Basel Engineering School. 1989 : Industry internship ABB Baden (CH). 1990-1993 : PhD Thesis EPFL, on Solid Oxide Fuel Cell cathode reaction mechanisms. 1994-1995 : Japanese Postdoctoral Fellowship in Tsukuba, Japan. 1995-2000 : Researcher at EPFL, Dpt. Chemistry : project responsible. 1998-2000 : Masters in Energy Technology, EPFL. 2000 : Cofounder of HTceramix SA (EPFL spin-off), based in Yverdon (14 employees). Since 2000 : 1st Assistant and chargé de cours at LENI (STI-IGM). M.E.R. since Nov 2008. Total funding raised so far >8 MCHF (50% as main applicant; 30% outside CH; 20% industry). Scientific output : 83 peer-reviewed publications (1100 citations), 48 conference papers, 21 invited presentations (6 keynotes), 40 granted proposals (20 as main applicant). Keywords: solid oxide fuel cells, biofuels, catalysis, solid state electrochemistry, modeling. http://leniwww.epfl.ch/

2007-2009 Significant Publications Diethelm, S., Bayraktar, D., Graule, T., Holtappels, P., Van herle, J., “Improved stability of La0.5Sr0.5FeO3 by Ta-doping for oxygen separation membrane application”, Solid State Ionics (22/06/2009), 857-860 Luebbe, H., Van herle, J., Hofmann, H., Bowen, P., Aschauer, U., Schuler, A., Snijkers, F., Schindler, H.-J., Vogt, U., Lalanne, C., “Cathode-supported micro-tubular SOFCs based on Nd1.95NiO4 + δ: Fabrication and characterisation of dip-coated electrolyte layers”, Solid State Ionics (22/06/2009), 805-811 Christian Monachon, Aïcha Hessler-Wyser, Antonin Faes, Jan Van herle, Enrico Tagliaferri, “Rapid preparation and SEM microstructural characterization of Nickel-Yttria Stabilized Zirconia cermets ”, J. Amer. Ceram. Soc (01/10/2008), 3405-07 Nakajo, A., Wuillemin, Z., Van herle, J., Favrat, D., “Simulation of thermal stresses in anode-supported solid oxide fuel cell stacks. Part II: Loss of gas-tightness, electrical contact and thermal buckling”, J. Power Sources (01/08/2009), 216-226 Nakajo, A., Wuillemin, Z., Van herle, J., Favrat, D, “Simulation of thermal stresses in anode-supported solid oxide fuel cell stacks. Part I: Probability of failure of the cells”, J. Power Sources (01/08/2009), 203-215 Faes, A, Nakajo, A, Hessler-Wyser, A, Dubois, D, Brisse, A, Modena, S, Van herle, J., “RedOx study of anode-supported solid oxide fuel cell”, J. Power Sources (01/08/2009), 55-64 J. Van herle*, D. Perednis, K. Nakamura, S. Diethelm, M. Zahid, A. Aslanides, T. Somekawa, Y. Baba, K. Horiuchi, Y. Matsuzaki, M. Yoshimoto, O. Bucheli, “Ageing of anode supported solid oxide fuel cell stacks including thermal cycling, and expansion behaviour of MgO-NiO-anodes”, J. Power Sources (01/08/2008), 389-399 Z. Wuillemin*, N. Autissier, M-T. Luong, J. Van herle, D. Favrat, “Modeling and study of the influence of sealing on a solid oxide fuel cell”, Journal of Fuel Cell Science & Technology (01/02/2008), 011016

Audit 2009 - Vol. C Activity Report

School of Engineering

Research Interests Solid Oxide Fuel cell group responsible (10 members), projects on biogas (Federal Energy Office), woodgas (CCEM), bioethanol (COST), fuel cell stacking (CTI, FP6, FNS), ceramic separation membranes (COST, FNS), microtubes (STI Seed), stability/lifetime/reliability in fuel cells (Electricité de France, swisselectric research). Understanding and mitigation of performance and lifetime degrading phenomena in high temperature fuel cells. Conversion of biofuels in fuel cells. Use of impedance spectroscopy. Bringing fuel cells from the laboratory to the market, combining the disciplines of mechanical, chemical, materials science and electrical engineering in the field.

2007-2009 External Grants received at the EPFL Swisselectric Research 2007-2010 Swiss Federal Energy Office 2008-2010 Swiss Federal Energy Office 2009 Swiss Federal Energy Office 2009-2011 SER COST 2009-2010 Private industry 2009-2011 FP7 - JTI 2009-2012 CCEM 2007-2010

Current Group 1 Senior Scientist 7 PhD Students 1 Scientific Collaborator 1 Engineer 1 Master Student

Collaborations & Networks CHF 720’000 EPFL : strong interaction with other laboratories. Four out of seven theses are colateral with SB (GGEC, CIME) and IMX (LTP). New project CHF 145’000 in preparation with LA. CHF 13’000 Switzerland : collaboration with PSI, EMPA, ETHZ, ZHAW via joint projects (swisselectric, CCEM). CHF 133’000 Europe : involved in FP-6 and FP-7 projects (and in COST), bringing CHF 128’000 exchange in competence, results, personnel. Numerous bilateral exchanges with Universities and Research Institutes in B, CZ, D, DK, E, CHF 75’000 F, FIN, GR, IT, N, NL, POR, UK. CHF 300’000 Overseas : personal contacts with Japan (AIST Tsukuba, Tohoku University), USA (Colorado School of Mines, National Fuel Cell Center CHF 230’000 Irvine). Fluent in 5 languages (Dutch, French, German (Swiss-german), English, Spanish). Teaching Activities Currently 7 Ph D ongoing theses. Regular semester course (14-16h) in summer (Advanced Energy Conversion) Energy Doctoral School (8h, Fuel Cells). 3h modules to chemists, physicists, as part of a master course (winter). The fuel group coaches on average 6-7 students per semester (master, bachelor, trainee,...).

Audit 2009 - Vol. C

Activity Report

School of Engineering

Laboratory for Computer-aided Design and Production Paul Xirouchakis, Full Professor July 1995-Present, Professor and Director of CAD/CAM Lab, EPFL 1987-May 1995, JJMA., Arlington, VA, USA 1985-1987 , Associate Professor (with tenure), NTUA, Greece 1978-1985 , Assistant/Associate Professor, MIT 1978 ,MIT, Ph.D. in Structural Mechanics Keywords: Computer-aided manufacturing, computer-aided design, sustainable manufacturing. http://licpwww.epfl.ch/

2007-2009 Significant Publications DY Kim and P Xirouchakis, “CO2DE: a decision support system for collaborative design”, J Engineering Design (2009), Vol. 20, in press JK Rai and P Xirouchakis, “FEM prediction of workpiece temperatures and deformations during milling”, Int J Advanced Manufacturing Technology (2009), 429-449 JK Rai, A Mousavi, P Xirouchakis, “An intelligent system for predicting HPDC process”, J Materials Processing Technology (2008), 72-79 JK Rai, P Xirouchakis, “FEM machining simulation for analyzing part errors induced during milling ”, Int J Machine Tools and Manufacture (2008), 629-643 JK Rai, L Villedieu ,P Xirouchakis, “Mill-cut: thermo-mechanical loads induced in end-milling operations”, Int JAdvanced Manufacturing Technology (2008), 256-264 HB Jun, M Cusin, D Kiritsis, P Xirouchakis, “A multi-objective evolutionary algorithm for EOL product recovery optimization”, Int J Production Research (2007), 4573-4594 Kim, H-J, Lee D-H, P Xirouchakis, “Disassembly scheduling: literature review and future directions”, Int J Production Research (2007), 44654484

Audit 2009 - Vol. C Activity Report

School of Engineering

Research Interests Societal challenges that LICP addresses: optimize the sustainable development of products sustainability of manufacturing systems operation of used product recovery systems

Current Group 2 Senior Scientists 1 Scientific Collaborator 8 PhD Students (external)

LICP is addressing these challenges with advances made towards the development of: Computer-aided methods and tools for product life-cycle management, - to extract precise information from embedded and web-enabled product data - to optimize the complex product system (nonlinear, uncertain, real-time) Near-zero waste manufacturing systems, - to reduce energy consumption, waste and pollution - to achieve near-zero downtime - to optimize manufacturing strategies for new processes, materials and architectures Inverse manufacturing systems, - to optimize the planning and scheduling of the uncertain timing, quantity and quality of used product recovery flows.

2007-2009 External Grants received at the EPFL OFES FP7 IMS2020 2009-2011

Teaching Activities CHF 330’000 At LICP we are responsible for teaching:

OFES FP6-STREP PRIME 2005-2007

CHF 362’000 1. Design for X, 6th sem Bachelor’s

OFES FP6-NoE: VRL-KCiP 2004-2008

CHF 223’000 2. Computer-aided manufacturing, 7th sem Master’s

OFES FP6-IP PROMISE 2004-2008

CHF 1’168’000 3. Computer-aided design, 8th sem, Master’s

OFES FP6-IP NEXT 2005-2009

CHF 772’000 4. Multi-body dynamics simulation, 8th sem Master’s

OFES FP6-IP KoBaS 2004-2007

CHF 649’000 5. Manufacturing Information Systems, doctoral

INTERREG IV SMAC 2009-2011

CHF 100’000 6. Decision-based approaches in conceptual and collaborative design, doctoral

Collaborations & Networks Within the “E-GPR: European Global Product Realization” teaching project (2002-present):

LICP participating in “E-GPR: European Global Product Realization” teaching project in collaboration with TU Delft, TU Ljubljana, City Univ London, TU Zagreb and TU Budapest.

1. TU Delft 2. TU Ljubljana 3. City Univ London 4. TU Zagreb 5. TU Budapest Within (VRL-KCIP) Network of Excellence, (2004-2008): 1.INPG 2. TU Delft 3. Polimi 4. Univ Stuttgart 5. Univ Berlin 6. UnivDurham

Audit 2009 - Vol. C

Activity Report

School of Engineering

Institute of Materials

Group Damjanovic Dragan Damjanovic, Adjunct Professor Dragan Damjanovic received his B.Sc. diploma in physics (suma cum laude) from the University of Sarajevo, in 1980, and Ph.D. in Ceramics Science from the Pennsylvania State University (PSU) in 1987. From 1988 to 1991 he was a research associate in the Materials Research Laboratory at the PSU. He joined the Ceramics Laboratory, Institute of Materials, at the Swiss Federal Institute of Technology in Lausanne (EPFL) in 1991. He is currently an adjunct professor and teaches undergraduate and graduate courses on electrical properties of materials.His research interests include dielectric, piezoelectric and ferroelectric properties of crystals, films, and ceramics as well as application of ferroelectric and piezoelectric materials in actuators, sensors, and high frequency transducers. He has published more than 150 articles. In the last ten years he has participated in or led more than a dozen European and Swiss projects in the field of piezoelectric materials. He is an IEEE Fellow. Keywords: piezoelectric, ferroelectrics, sensors, actuators, medical transducers. http://lc.epfl.ch/

2007-2009 Significant Publications V. Porokhonskyy, Li Jin, and D. Damjanovic, “Separation of piezoelectric grain resonance and domain wall dispersion in Pb(Zr,Ti)O3 ceramics”, Appl. Phys. Lett. (2009), Vol. 94, article no. 212906 J. Rödel, W. Jo, K. Seifert, E.-M. Anton, T. Granzow, and D. Damjanovic, “Perspective on the Development of Lead-free Piezoceramics”, J. Am. Ceram. Soc. (invited feature) (2009), Vol. 92 (6), 1153-1177 W. Jo, T. Granzow, E. Aulbach, J. Rödel, and D. Damjanovic, “Origin of the large strain response in (K0.5Na0.5)NbO3modified (Bi0.5Na0.5)TiO3-BaTiO3 lead-free piezoceramics”, J. Appl. Phys. (2009), Vol. 105, article no. 094102 S-T. Zhang, A. B. Kounga, W. Jo, C. Jamin, K. Seifert, T. Granzow, J. Rödel and D. Damjanovic, “High-Strain Lead-free Antiferroelectric Electrostrictors”, Advanced Materials (2009), in press D. Damjanovic, “Comments on origins of enhanced piezoelectric properties in ferroelectrics”, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control (2009), in press M.I. Morozov and D. Damjanovic, “Hardening-softening transition in Fe-doped Pb(Zr,Ti)O3 ceramics and evolution of the third harmonic of the polarization response”, J. Appl. Phys. (2008), Vol. 104 (3), article no. 034107 D. J. Keeble, S. Singh, R. A. Mackie, M. Morozov, S. McGuire, and D. Damjanovic, “Cation vacancies in ferroelectric PbTiO3 and Pb(Zr,Ti)O3: A positron annihilation lifetime spectroscopy study”, Phys. Rev. B (2007), Vol. 76, article no. 144109 M. Davis, M. Budimir, D. Damjanovic, N. Setter, “Rotator and extender ferroelectrics: Importance of the shear coefficient to the piezoelectric properties of domain-engineered crystals and ceramics”, J. Appl. Phys. (2007), Vol.. 101, article no. 054112

Audit 2009 - Vol. C Activity Report

School of Engineering

Current Group 5 Group Leaders

Research Interests Mechanisms of softening and hardening in ferroelectrics Lead-free piezoelectric materials Properties of ferroelectric-relaxor single crystals Contributions of domain-walls displacement to the piezoelectric, elastic and dielectric properties of materials Hysteresis and relaxation in piezoelectric materials Nonlinear electro-mechanical properties Piezoelectric sensors, actuators and ultrasonic transducers Transducers for ultrasonic imaging and biomedical applications High temperature piezoelectric materials Electro-mechanical effects in biopolymers

Outstanding Achievement Award, International Symposium on Integrated Ferroelectrics, 2007-00-00. Outstanding achievment in the field of integrated ferroelectrics

Institute of Physics, Academy of Sciences, Czech Republik, Prof. J. Petzelt: Broad band dielectric properties of ferroelectrics

Fellow, IEEE 2009-00-00 For contributions to piezoelectric ceramics and Teaching Activities “Dielectic and optical properties of materials”, master level, all sections, single crystals EPFL (2004-) “Ceramics: properties” third year, Materials Section, EPFL (2005- ) Distinguished Lecturer, IEEE Ultrasonics, Frequency Control, and (with E.L. Colla and N. Setter) Ferroelectrics Society “Ceramics: structures” second year, Materials Section, EPFL (2007- ) 2009-00-00 (with E.L. Colla and N. Setter) “Piezoelectric materials, properties and devices” doctoral school, all Ferroelectrics recognition award, IEEE Ultrasonics, Ferroelectrics and sections, EPFL (2004- ) Freqeuncy Control Society, 2009-00-00, For significant contribution to “Ceramics properties”, experimental excercises, third year, Materials the understanding of relations between crystal instabilities, anisotropy, Section, EPFL (1995-) and enhancement of electromechanical properties in piezoelectric ceramics and crystals Rodolphe and René Haenny Prize, Rodolphe and René Haenny Foundation, 2009-00-00, For manifold and important contributions to the understanding of the properties and the structure of electro-ceramics 2007-2009 External Grants received at the EPFL Swiss National Science Foundation 2009-2011 Swiss National Science Foundation 2007-2009 European FP7 2008-2011 Collaborations & Networks University of Florida, USA, Prof. J. L. Jones: piezoelectric nonlinearity Technical University of Darmstadt, Germany, prof. J. Roedel: lead free piezoelectrics Forschunginstitut für mineralische und metallische werkstoffe, Germany, Dr. D. Rytz: properies of ferroelectric single crystals European Network of Excelence MIND (Multifunctional & Integrated Piezoelectric Devices ) partnesr from Denmark, France, Italy, Slovenia, Latvia, Spain, United Kingdom University of Wellington, New Zealand, Prof. J. Trodahl; Raman spectrocopy and phase transitons in ferroelectric materials Audit 2009 - Vol. C

Activity Report

School of Engineering

Laboratory of Semiconductor Materials Anna Fontcuberta i Mofral, Tenure Track Assistant Professor 2005-2010 Marie Curie Excellence Grant Team Leader at ‘Walter Schottky Institut’, Technische Universität München, on leave from ‘Centre National de la Recherche Scientifique’ (CNRS, France). 2004-2005 Visiting Scientist at the California Institute of Technology, on leave from CNRS; Senior Scientist and co-founder of Aonex Technologies (a startup company for large area layer transfer of InP and Ge on foreign substrates for the main application of multi-junction solar cells), 2003 Permanent Research Fellow at CNRS, Ecole Polytechnique, France, 2001-2002 Postdoctoral Scholar at the California Institute of Technology. ‘Study of wafer bonding and hydrogeninduced exfoliation processes for integration of mismatched materials in views of photovoltaic applications’. Sponsor: Professor Harry A. Atwater. 1998-2001 PhD in Materials Science, Ecole Polytechnique. ‘Study of polymorphous silicon: growth mechanisms, optical and structural properties. Application to Solar Cells and Thin Film Transistors’. Advisor: Pere Roca i Cabarrocas. 1997-1998 Diplôme d’Etudes Approfondis (D.E.A.) in Materials Science at Université Paris XI, France. 1993-1997 BA in Physics at Universitat de Barcelona. At EPFL since 01.09.2008 Keywords: semiconductor nanostructure combinations, nanowires, chemical vapor deposition, catalyst-free molecular beam epitaxy. http://lmsc.epfl.ch/

2007-2009 Significant Publications Matthias Heigoldt, Jordi Arbiol, Dance Spirkoska, Josep M. Rebled, Sònia Conesa-Boj, Gerhard Abstreiter, Francesca Peiró, Joan R. Morante, Anna Fontcuberta i Morral, “Long Range Epitaxial Growth of Prismatic Heterostructures on the facets of Catalyst-Free GaAs Nanowires”, J. Mater. Chem. (2009), 840 M. Heiβ, A. Gustafsson, S. Conesa-Boj, F. Peiro, J.R. Morante, G. Abstreiter, J. Arbiol, L. Samuelson, A. Fontcuberta i Morral, “Catalystfree nanowires with axial InxGa1-xAs/GaAs heterostructures”, Nanotechnology (2009), 075603 I. Zardo, L. Yu, S. Conesa-Boj, S. Estradé, P.J. Alet, J. Rössler, M. Frimmer, P. Roca i Cabarrocas, F. Peiró, J. Arbiol, J.R. Morante, A. Fontcuberta i Morral, “Gallium assisted Plasma Enhanced Chemical Vapor Deposition of silicon nanowires”, Nanotechnology (2009), 155602 Y.Xiang, L. Cao, J.Arbiol, M. Brongersma, A. Fontcuberta i Morral, “Synthesis parameter space of bismuth catalyzed germanium nanowires”, Appl. Phys. Lett. (2009), 163101 C. Colombo, M. Heiβ, M. Graetzel, A. Fontcuberta i Morral, “Gallium arsenide p-i-n radial structures for photovoltaic applications”, Appl. Phys. Lett. (2009), 173108 Y. Xiang, L. Cao, S. Conesa-Boj, S. Estrade, J. Arbiol, F. Peiro, M. Heiβ, I. Zardo, J.R. Morante, M.L. Brongersma, A. Fontcuberta i Morral , “Single crystalline and core-shell indium catalyzed germanium nanowires – a systematic thermal CVD growth study”, Nanotechnology (2009), 023119

Anna Fontcuberta i Morral, Dance Spirkoska, Jordi Arbiol, Matthias Heigoldt, Joan Ramon Moranteand Gerhard Abstreiter, “Prismatic Quantum Heterostructures Synthesized on Molecular-Beam Epitaxy GaAs Nanowires”, Small (2008), 899 C. Colombo, D. Spirkoska, M. Frimmer, G. Abstreiter, A. Fontcuberta i Morral, “Growth mechanisms of Ga-assisted catalyst-free MBE GaAs nanowires”, Phys. Rev. B (2008), 155326 N. Isik, M. Bichler, S.F. Roth, A. Fontcuberta i Morral, O. Goektas, M. Grayson , “Shadow modulated two-dimensional heterostructures using vertical pillars”, Appl. Phys. Lett. (2008), 173505 E. Uccelli, M. Bichler, S. Nuremberger, G. Abstreiter, A. Fontcuberta i Morral, “Controlled synthesis of InAs wires, dot and twin dot array configurations by cleaved edge overgrowth”, Nanotechnology (2008), 045303 A. Fontcuberta i Morral, C. Colombo, J. Arbiol, J.R. Morante, G. Abstreiter, “Nucleation mechanism of gallium-assisted molecular beam epitaxy growth of gallium arsenide nanowires”, Appl. Phys. Lett. (2008), 063112 M. Heiβ, E. Riedelberger, M. Bichler, G. Abstreiter, A. Fontcuberta i Morral, “Nucleation mechanism of gallium-assisted Molecular Beam Epitaxy growth of Gallium Arsenide nanowires”, J. Cryst. Growth (2008), 1049 Y. Xiang, W. Lee, K. Nielsch, G. Abstreiter, A. Fontcuberta i Morral, “Microstructured horizontal alumina pore arrays as growth templates for large area few and single nanowire devices”, phys.stat.sol. (RRL) (2008), 59

D. Spirkoska, G. Abstreiter, A. Fontcuberta i Morral, “Size and environment dependence of surface phonon modes of gallium arsenide nanowires as measured by Raman Spectroscopy”, Nanotechnology (2008), 435704 J.D. Prades, A. Cirera, J. Arbiol, J.R. Morante, A. Fontcuberta i Morral, , “Concerning the 506cm-1 band in the Raman spectrum of silicon J. Arbiol, A. Fontcuberta i Morral, S. Estrade, F. Peiro, B. Kalache, P. nanowires”, Appl. Phys. Lett. (2007), 123107 Roca i Cabarrocas, J.R. Morante, “Influence of the (111) twinning on the formation of diamond cubic/diamond hexagonal heterostructures in Cu- S. Dasgupta, C. Knaak, J. Moser, M. Bichler, S.F. Roth, A. Fontcuberta i catalyzed Si nanowires”, J. Appl. Phys. (2008), 064312 Morral, G. Abstreiter, M. Grayson, “Donor binding energy and thermally activated persistent photoconductivity in high mobility (001) AlAs quantum wells”, Appl. Phys. Lett. (2007), 142120

Audit 2009 - Vol. C Activity Report

School of Engineering

Research Interests Our research activities are centered on the research of novel semiconductor nanostructure combinations, using mainly nanowires, which are filamentary crystals with a very high ratio of length to diameter, the latter being in the nanometer range. Semiconductor nanowires are of significant interest from a fundamental point of view as they exhibit new physical and chemical properties owing to their large surface-to-volume ratio, low dimensionality and confinement in one dimension. From a technological perspective, they constitute attractive building blocks for the assembly of novel nano-electronic and nano-photonic systems, as well as biochemical sensor.

Current Group 1/2 Postdoctoral Fellow 1 Master Student 3 PhD Students 1 Administrative Assistant

Our synthesis methods span from the standard Chemical Vapor Deposition to catalyst-free Molecular Beam Epitaxy. Examples of our experimental methods are to study the fundamental properties that span from optical and Raman spectroscopy to magnetotransport.

J. M. Zahler, A . Fontcuberta i Morral, M. Griggs, H. A. Atwater, Y. J. Chabal, “Role of hydrogen in hydrogen-induced layer exfoliation of germanium”, Phys. Rev. B (2007), 035309

2007-2009 External Grants received at the EPFL Swiss National Science Foundation 2009-2011

European Research Council 2010-2015

J. Arbiol, B. Kalache, P. Roca i Cabarrocas, J. R. Morante, A. Fontcuberta i Morral, “Influence of Cu as a catalyst on the properties of silicon nanowires synthesized by the Vapor-Solid-Solid mechanism”, Nanotechnology (2007), 305606

Collaborations & Networks Prof. Gerhard Abstreiter, Prof. Alex Holleitner, Walter Schottky Institut, Technishe Universitaet Muenchen, Germany Dr. Elisabeth Reiger, Universitaet Regensburg, Germany· Dr. Jordi Arbiol, Prof. Francesca Peiro, Universitat de Barcelona, Spain· Prof. Joan Ramon Morante, Institut of Energy, Barcelona, Spain· Prof. Pere Roca i Cabarrocas, Ecole Polytechnique, France

A . Fontcuberta i Morral, J. Arbiol, J.D. Prades, A. Cirera, J.R. Morante, “Synthesis of silicon nanowires with wurtzite crystalline structure by standard Chemical Vapour Deposition’ ”, Adv Mater (2007), 1347 J. M. Zahler, A . Fontcuberta i Morral, M. Griggs, H. A. Atwater, Y. J. Chabal, “Role of hydrogen in hydrogen-induced layer exfoliation of germanium”, Phys. Rev. B (2007), 035309 2007-2009 Awards ERC Starting Grant, ERC

CHF 1’900’000

Prof. Marc Brongersma, Stanford University, USA Prof. Alexander Efros, Naval Research Laboratory at Washington, USA Teaching Activities Introduction to Materials Science (PhD students) Semiconductor materials, from the bulk to the nanostructure (Master)

2007-2009 Patents J.Liu, A. Fontcuberta i Morral, “Carbon Nanotubes as Interconnects in Integrated Circuits and method of fabrication”: WO/2007/064530 A. Fontcuberta i Morral, J. M. Zahler, C. Ladous, Harry A. Atwater Jr., Sean M. Olson, “Method of forming semiconductor layers on handle substrates”: PCT/US2006/030374, WO/2007/019277

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Laboratory of Macromolecular and Organic Materials Holger Frauenrath, Tenure Track Assistant Professor Holger Frauenrath (born in Aachen, Germany) studied chemistry at RWTH Aachen, Germany from 1992 to 1997, with a strong focus on synthetic organic chemistry. He performed his PhD thesis from 1998 to 2001 in the research group of Prof Hartwig Höcker at RWTH Aachen, working on a project related to the stereospecific polymerization of methacrylates as well as their copolymerization with olefins using zirconocene catalysts. Holger Frauenrath then joined the group of Prof. Sam Stupp at Northwestern University, Evanston, IL, USA, as a postdoctoral fellow supported by a Feodor Lynen fellowship of the Alexander von Humboldt Foundation. His postdoctoral research projects were centered around the supramolecular self-assembly of rod-coil molecules. Holger Frauenrath returned to Germany in 2003 and started to build his own research group at FU Berlin, funded with an Emmy Noether Grant from the German Science Foundation. In 2005, the research group moved to ETH Zurich, Switzerland, where they were a scientifcally independent part of the polymer chemistry group led by Prof. A. Dieter Schlüter. Holger Frauenrath obtained his Habilitation from ETH Zurich in 2009. In 2009, Holger Frauenrath has been appointed as a professor at the Institute of Materials (IMX) of the Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland, building the new Laboratory of Macromolecular and Organic Materials (LMOM). Recently, he received the prestigious European Research Council Starting Investigator Award. At EPFL since 01/01/2009 Keywords: organic synthesis, supramolecular chemistry, polymer science. http://lmom.epfl.ch

2007-2009 Significant Publications J. Gebers, D. Rolland, H. Frauenrath, “Coordination-Driven Self-Assembly of PEO-functionalized Perylene Bisimides – Supramolecular Diversity from a Limited Set of Molecular Building Blocks”, Angew. Chem. Int. Ed. (2009), 48, 4480-4483 J. Gebers, D. Rolland, H. Frauenrath, “Synthesis of Diacetylene-Containing Peptide Building Blocks and Amphiphiles, their Self-Assembly and Topochemical Polymerization in Organic Solvents”, Chem. Eur. J. (2009), 15, 388-404 R. Xu, W. B, Schweizer, H. Frauenrath, “Perfluorophenyl-Phenyl Interactions in the Crystallization and Topochemical Polymerization of Triacetylene Monomers”, Chem. Eur. J. (2009), 15, 91059116 E. Jahnke, P. Kreutzkamp, Nikolai, J. P. Rabe, H. Frauenrath, “Molecular Level Control over Hierarchical Structure Formation and Polymerization of Oligopeptide-Polymer Conjugates”, Adv. Mater. (2008), 20, 409-414 H. Frauenrath, E. Jahnke, Chem. Eur. J., “A General Concept for The Preparation of Hierarchically Structured Conjugated Polymers”, Chem. Eur. J. (2008), 14, 2942-2955 J. Weiss, E. Jahnke, N. Severin, J. P. Rabe, H. Frauenrath, “Consecutive Conformational Transitions and Deaggregation of Multiple-Helical Po ly(diacetylene)s”, Nano Lett. (2008), 8, 1660-1666 T. Hoheisel, H. Frauenrath, “A Convenient Negishi Protocol for the Synthesis of Glycosylated Oligo(ethynylene)s”, Org. Lett. (2008), 10, 4525-4528 R.Xu, W. B. Schweizer, H. Frauenrath, “Soluble Poly(diacetylene)s Using the PerfluorophenylPhenyl Motif as a Supramolecular Synthon”, J. Am. Chem. Soc. (2008), 130, 11437-11445 2007-2009 Awards Reimund Stadler Award of the German Chemical Society , Gesellschaft deutscher Chemiker, GdCh 2008 Starting Independent Researcher Award, European Research Council (ERC) 2009

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Research Interests In the research of his group, Holger Frauenrath has aimed to combine his expertise in organic synthesis, supramolecular chemistry, and polymer science in different research projects that have a common focus on the preparation and characterization of nanostructured organic and macromolecular materials. The common theme is to mimic the methods of hierarchical structure formation observed in biomaterials, and transfer them to synthetic materials with properties unknown in biology, such as semincoductivity. The current research projects include investigations on spider-silk mimicking polymers, hydrogen-bonded π-conjugated oligomers and polymers, as well as carbonaceous materials from molecular precursors.

2007-2009 External Grants received at the EPFL SNF 2009-2012 European Research Council 2009-2014

Current Group 1 Postdoctoral Fellow 8 PhD Students 1 Master Student 1 Administrative Assistant

CHF 345’000 CHF 2’584’000

Teaching Activities WS 2007/8 “Supramolecular Chemistry of Advanced Materials”, ETH Zurich WS 2008/9 “Supramolecular Chemistry of Advanced Materials”, ETH Zurich WS 2009/10 “Supramolecular Aspects of Polymer Materials”, EPFL

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Powder Technology Laboratory (Hofmann, Lemaitre, Bowen) Heinrich Hofmann, Full Professor Hofmann Heinrich Prof. H. Hofmann got his PhD in Material Science with a thesis prepared at the Powder Metallurgy Laboratory at the Max Planck Institute in Stuttgart. In 1985 he joins the R&D center of Alusuisse-Lonza Services AG, at Neuhausen-am-Rheinfall. In 1993 he joins the Swiss Federal Institute of Technology as Professor and Director of the Powder Technology Laboratory at the Department of Materials science and engineering. His research area includes the synthesis of nanostructured materials based on nanoparticles and the modification of surfaces with nanoparticles using colloidal methods. The fields of application of such materials are medical and biological, (drug delivery, hyperthermia, cell separation, biosensors), electronics and sensors. Keywords: Powder technology, Colloidal chemistry, Biomaterial, Nanomaterial. http://ltp.epfl.ch/

Research Interests The Powder Technology Laboratory (LTP) research is focused on various aspects of particles and powders including synthesis, characterisation, and surface functionalization. The aim of the research is to understand a) the fundamental steps of powder processing especially colloidal chemistry, powder packaging and consolidation and b) the physical and chemical basic behind these various technologies to improve the processing routes for materials of technological and economical importance. Special emphasis is given to the development of new nanostructured particles and their processing to multifunctional materials for medical, biological, electronic, and sensor application. Nanosized inorganic powders are synthesized by precipitation from aqueous solutions, performing an excellent control of powder characteristics, which is needed to produce materials with optimal performance. One of the specialties at LTP is the synthesis of polycrystalline particles based on the controlled agglomeration or assembly of primary nanoparticles. This allows tuning physical properties like magnetic strengths, optical absorption and electrical conductivity of the material. Another field of interest is the biological functionalisation of nanoparticles for drug and gene delivery and to use these innovative methods as delivery platform for implants, in particular for stents and prostheses. Nanostructured materials and coatings provide novel properties and functions to biomaterials which are not achievable with bulk material. To process nanosized ceramic powders for coating structures with controlled porosity with a size range of 20 nm to 40 micro meter between the smallest and largest pore. This leading edge technology is based on long term fundamental research activities at LTP in the field of ordered arrangement of nanosized particles at surfaces. LTP has established the knowledge of processing particles smaller than 10 nm at large scale, a key competence to achieve that goal. The powder technology research is done in the area of compaction and sintering of inorganic powders. LTPâ&#x20AC;&#x2122;s special interest is the research of the colloidal behaviour of suspension with inorganic particles. One focus of activity is the development of bioresorbable materials for bone filling and skeletal reconstruction (principal investigator J.LemaĂŽtre), which could substitute conventional bone grafts (autografts, allografts and xenografts). Pastes with various consistencies of such materials (Calcium-Phosphate Hydraulic Cements, CPHC) can be prepared and are able to consolidate in vivo. Additional, preparation of bonesubstitutes based on dense nano-hydroxyapatite/polymer composites are under investigation. Beside the synthesis und processing of various nanoparticles and powders, their characterization and that of the suspension is another main activity. LTP has a long term knowledge in characterizing especially nanoparticles by using sophisticated and well matured methods. This guarantees the highest quality of research and development in this field and enables the researchers at LTP to gain a complete picture of the particle and suspension properties. The projects undertaken at LTP are in most cases a translation from basic findings into the industrial applications. Therefore many of them are implemented in very close contact with industrial partners. The need to understand surfaces and interfaces at an atomistic level rather than treat the materials as a continuum is now of prime importance in many areas of research. Experimental methods to access the surfaces and grain boundaries at an atomistic level are often complicated and the resolution limited. This is why simulation at the atomic scale has bben recently launched at LTP which can give important information about structures and processes active during the preparation of ceramic powders and the processing of these powders to produce the final ceramic, without forgetting the ceramic properties themselves. 100

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ÂŠ EPFL 2009

Paul Bowen Dr. P. Bowen obtained his Ph.D. in Physical Chemistry in the field of catalysis from the University of Cambridge, UK, in 1982. He then worked at the BP Research Centre, Sunbury, UK, for 4 years in applied surface sciences before moving to Switzerland and EPFL in1987. He has been at the Powder Technology Laboratory, in the Materials Institute since its conception in 1988. He has over 120 publications and has written an undergraduate book on ceramic processing. His main research interests are inorganic powder synthesis powder charactersiation, colloidal processing sinetring of ceramics and atomistic modelling of surfaces and interfaces for applications as varied as transparent ceramics and the building industry.

Jacques Lemaitre Prof. J. Lemaitre graduated in chemical engineering, and earned his PhD in the field of ceramic processing at the University of Louvain (Belgium). He then specialized in finely divided materials (e.g. heterogeneous catalysts) and in inorganic chemistry of calcium phosphates. He joined LTP in Fall 1988 as a senior scientist, for leading a group working on the chemical processing of piezoelectric ceramics. He also started a research group focused on calcium phosphate-based bone substitutes: this work has lead to the development of cement-like injectable bone graft substitutes.

2007-2009 Significant Publications Gay S, Arostegui S & Lemaitre J, “Preparation and characterization of dense nanohydroxyapatite/PLLA composites.”, Materials Science and Engineering C 29 (2009), 172-177

Blech K, Noyong M, Juillerat F , Nakayama T , Hofmann H , Simon U, "In-situ electrical addressing of one-dimensional gold nanoparticle assemblies, Vol. 8 ", JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY vol 8 (2008), 461-465

Petri-Fink, Alke ; Steitz, Benedikt ; Finka, Andrija ; Salaklang, Jatuporn, H.Hofmann, “Effect of cell media on polymer coated superparamagnetic iron oxide nanoparticles (SPIONs): colloidal stability, cytotoxicity, and cellular uptake studies”, European Journal of Pharmaceutics and Biopharmaceutics, vol. 68 (2008), 129–137

Salaklang, Jatuporn ; Steitz, Benedikt ; Finka, Andrija ; O'Neil, Conlin P. J. Hubbell, H,.Hofmann, A. Fink-Petri. , " Superparamagnetic Nanoparticles as a Powerful Systems Biology. Characterization Tool in the Physiological Context", Angewandte Chemie, International edition, vol. 47 (2008), 7857-7860

Kamau Chapman, Sarah W. ; Hassa, Paul O. ; Koch-Schneidemann, Sabine ; von Rechenberg, Brigitte Margarethe Hofmann-Amtenbrinkd, Benedikt Steitze, Alke Petri-Finke, Heinrich Hofmanne, Michael O. Hottiger , "Application of pulsed-magnetic field enhances non-viral gene delivery in primary cells from different origins ", Journal of Magnetism and Magnetic Materials (2008 ), 1517-1527

Steitz B, Salaklang J, Finka A, O`Neil C, Hofmann H, Petri-Fink A., , " Fixed bed reactor for solid phase surface derivatization of superparamagnetic nanoparticles Bioconjugate Chemistry, Vol 18 , 2007", Bioconjugate Chemistry, vol 18 (2007), 1684-1690

U. Aschauer, P. Bowen and S.C. Parker, , "Surface and Mirror Twin Grain Boundary Segregation in Nd:YAG: An Atomistic Simulation Study", J. Am. Ceram. Soc., 91 (2008), 2698-2705

R. J. Flatt, P. Bowen,, " Yield Stress of multimodal powder suspensions : an extension of the YODEL (Yield stress mODEL)", J.Amer.Ceram. Soc., 90 (2007), 1038-1044 Galmarini, S., Aschauer, U., Bowen, P., and Parker,S.C.,, "Atomistic Simulation of Y doped gamma-Alumina Interfaces", J.Amer.Ceram.Soc. 91 (2008), 3643–3651 continued over page

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- Ecole Nationale Supérieure d'Electrochimie et d'Electrométallurgie de Grenoble/Laboratoire de Thermodynamique et Physico-Chimie Métallurgiques - Eduardo Torroja Institute - Heriot Watt University IP Nanoker (25 partner EU project ) Working group - Hopital Orthopédique de la Suisse Romande leader WG8 Modelling and simulation - INP-CRNS-UJF, Grenoble - INSA Lyon Institute for Reference Materials and Measurements - Iowa State University/ Materials Science (IRMM), Belgium. and Engineering Department - Josef Stefan Institute, Slovenia Nanocem – European network (25 parteners - Karolinska Institutet/Clinical Immunology academic and induustrial ) cementitious materials - Max-Plank Institut fürKolloidchemie, Golm - Centre Hospitalier Universitaire Vaudois - Max Planck Institut for Molecular Genetics, - Consiglio Nazionale delle Ricerche, Berlin Dalhem Istituto di Chimica Fisica Applicata dei Materiali, - Materials Institute CSIC Mardid Genova - NIST USA - Dr. h.c. Robert Mathys Stiftung - Politecnico Torino, Italy Collaborations & Networks Swiss representative for the COST Action 539, coordinator of Working Group 1: Synthesis and characterization of nanopowders prepared by nonconventional techniques.

- Princeton University - Royal Institute of Technology/Engineering Material Physics - Royal Institute of Technology/Materials Chemistry - Tierspital Zürich, Universität Zürich - University of Bath - Universität Zürich/Veterinär-chirurgische Klinik - Université de Fribourg - Université de Genève - Université Paul Sabatier, Toulouse - Université de Paris Sud - University College London/Department of Chemical Engineering - University of Lund - University ofsheffield - University of Stockholm - Charité

2007-2009 Awards Wassermann Price, Wassermann 2009-01-01 Price for the best PhD thesis in the field of Material Science (10'000 CHF for Uli Aschauer) SNF Professor boursier, SNF 2009-02-01 Funding a 4 year professorship for Dr Alke Fink-Petri at the University of Fribourg 2007-2009 Patents L.Piveteau, H.Hofmann, " Porous coating including fluid reservoirs ": WO 2008/018 024 L.Piveteau, H.Hofmann et al., "Reinforced porous coating ": WO 2007/931 972 L.Piveteau, H.Hofmann et al., "Anisotropic nanoporous coating ": WO 2007/148 240 L. Piveteau, H.Hofmann et al., "Porous coating loaded with a liquid or solid substance ": WO 2007/031 968 Steitz, Benedikt ; Petri-Fink, Alke ; Salaklang, Jatuporn ; Finka, Andrija, H.Hofmann, "Magnetic, paramagnetic and/or superparamagnetic nanoparticles ": PCT/IB2007/05469 Kubel, Frank ; Bowen, Paul, "Phosphorescent compounds": EP 1837387 Reinert, Michael ; Bregy, Amadé ; Steitz, Benedikt, Petri-Fink, Alke H.Hofmann. , "Superparamagnetic iron oxide nanoparticle coupled tissue soldering ": EP 07007600.5 Kubel, Frank ; Bowen, Paul, "Phosphorescent compounds": US 2007210282

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Companies: - Asulab - Biakowski - Borregaard LignoTech - CalciTech - Ceramaret - Devex - GlasKeller - Ilford - KPCL - Liquids Research Limited - LUM GmbH - Mathys - micromod Partikeltechnologie GmbH - Oxidkeramiclabor - Sika - Sintec Keramik - SPT Roth - St. Gobain

- Synthes Stratec - Sulzer - Timcal - Union Minière - Rolex - Debiotech - ANTIA - Zeochem

2007-2009 External Grants received at the EPFL SNF, 3200B0-104508, cooperation with UNI Geneva 2004-2008 SNF, 205321-120161 2008-2010 SNF, 205321-111908 2006- 2009 SNF, 122288 2009-2012 NanoCem 2009-2013 Industry, SIKA 2009 Industry, SICPA 2007-2008

Teaching Activities Bachelor CHF 30’000 - Ceramiqie precedée (Hofmann, Bowen) - Phénomèn des transfert (Hofmann, Bowen) CHF 179’869 - Analyse des Microstructure (Hofmann) CHF 160’172 Master - Indroduction to Nanostructured Materials (Hofmann) CHF 349’450 - Powder Technology (Hofmann, Bowen) - Advanced Nanomaterials (Hofmann) CHF 353’000 - Thermodynamique (Lemaitre, Bowen) - Biomatériaux (matériaux pour usage biomédical) (Lemaitre) CHF 55’000 - Matériaux biomimétiques, (Lemaitre) - Optimisation des matériaux et plans d’expériences (méthodologie CHF 133’000 expérimentale) (Lemaitre)

CHF 180’000 Graduate School - Functionalized nanoparticles for biomedical application Industry, Ivoclar 2008-2009 CHF 126’000 (Hofmann, Fink) - Principles of powder and densification processes (Hofmann, Mortensen) European Office of US-Airforce Research and Development 2008 CHF 50’000 - Nanostructured materials (Hofmann) - Powder Characaterisation (Bowen) EU 7th Framework, Nanoker 2006-2010 CHF 292’000 Current Group EU 7th Framework, Nanodiara; Start 10/09 2009 CHF 1500’000 2 Senior Scientists 1 Adjunct Professor EU 7th Framework, Nanobiocom 2005-2007 (only 2007) CHF 16’690 2 Postdoctoral Fellows 8 PhD Students CTI, Nanostent 2006-2009 CHF 306’000 1 Administrative Assistant 2 Laboratory Assistants CTI, Hyperthermia 2008-2010 CHF 336’000 2 PhD Students (external) 2 Master Students CTI, Boneimplantes 2007-2009 CHF 103’950 4 Visiting Students Industry, Rolex 2006-2008

CTI, Biocartis 2009 COST, Nanometro 2007-2008

CHF 97’000 CHF 139’000

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Polymers Laboratory Harm-Anton Klok, Full Professor Director of the Section of Materials Science and Engineering, Member of the EPFL Research Commission Harm-Anton Klok was born in 1971 and studied chemical technology at the University of Twente (Enschede, The Netherlands) from 1989 to 1993. He received his Ph.D. in 1997 from the University of Ulm (Germany) after working with M. Möller. After postdoctoral research with D. N. Reinhoudt (University of Twente) and S. I. Stupp (University of Illinois at Urbana–Champaign, USA), he joined the Max Planck Institute for Polymer Research (Mainz, Germany) in early 1999 as a project leader in the group of K. Müllen. In November 2002, he was appointed to the faculty of EPFL. Keywords: Biologically-inspired hybrid block copolymers, Biofunctional Surfaces, Precision Polymerization. http://lp.epfl.ch/

2007-2009 Significant Publications J. Wang, M. I. Gibson, R. Barbey, S.-J. Xiao, H.-A. Klok, “Nonfouling polypeptide brushes via surface-initiated polymerization of Nε-oligo(ethylene glycol)succinate-L-lysine N-carboxyanhydride”, Macromol. Rapid Commun. (2009), 30, 845 – 850. M. A. Gauthier, M. I. Gibson, H.-A. Klok, “Synthesis of functional polymers by post-polymerization modification”, Angew. Chem. Int. Ed. (2009), 48, 48 – 58. S. Tugulu, H.-A. Klok, “Stability and nonfouling properties of poly(poly(ethylene glycol) methacrylate) brushes under cell culture conditions”, Biomacromolecules (2008), 9, 906 – 912. B. Apostolovic, H.-A. Klok, “pH-Sensitivity of the E3/K3 heterodimeric coiled coil”, Biomacromolecules (2008), 9, 3173 – 3180. M. A. Gauthier, H.-A. Klok, “Peptide/protein – polymer conjugates: synthetic strategies and design concepts”, Chem. Commun. (2008), 2591 – 2611. S. Tugulu, R. Barbey, M. Harms, M. Fricke, D. Volkmer, A. Rossi, H.-A. Klok,, “Synthesis of poly(methacrylic acid) brushes via surface-initiated atom transfer radical polymerization of sodium methacrylate and their use as substrates for the mineralization of calcium carbonate”, Macromolecules (2007), 40, 168 – 177. S. Tugulu, P. Silacci, N. Stergiopulos, H.-A. Klok, “RGD-functionalized polymer brushes as substrates for the integrin specific adhesion of human umbilical vein endothelial cells”, Biomaterials (2007), 28, 2536 – 2546. W. Fieber, A. Herrmann, L. Ouali, M. I. Velazco, G. Kreutzer, H.-A. Klok, C. Ternat, C. J. G. Plummer, J.-A. E. Månson, H. Sommer, “NMR diffusion and relaxation studies of the encapsulation of fragrances by amphiphilic multiarm star block copolymers”, Macromolecules (2007), 40, 5372 – 5378. 2007-2009 Awards Associate Editor of the American Chemical Society Journal Biomacromolecules, American Chemical Society Arthur K. Doolittle Award, American Chemical Society (Polymeric Materials: Science and Engineering Division) 2007-2009 Patents B. Bruchmann, H.-A. Klok, M. Scholl, “Production and use of highly functional, highly branched or hyperbranched polylysines”: WO 2006-EP68479 20061115; H.-A. Klok, L. Lavanant, “Selectively permeable coated biointerface membrane for implantable analyte sensor.": US 2009112075

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Research Interests The research activities of our laboratory are subdivided in three major areas: (i) peptide/protein – synthetic polymer hybrid materials, (ii) polymer brushes and (iii) precision polymerization. Our activities in the area of peptide/protein – synthetic polymer hybrids aim at the design and preparation of novel materials, in particular for biomedical applications, by intelligently and synergistically combining the properties of synthetic polymers and their biological counterparts. Our interest in tthe area of polymer brushes is in using so-called controlled surfaceinitiated polymerization techniques to prepare polymer brush based coatings to tune the surface properties of a wide variety of materials. The term precision polymerization refers to the synthesis of polymers with a well-defined composition and architecture. In this area we are developing various star-shaped, dendritic and hyperbranched polymers that are designed to encapsulate, transport and release various guest substances.

Current Group 1 Administrative Assistant 1 Senior Scientist 6 Scientists 11 PhD Students (external) 1 Laboratory Assistant 1 Technician Apprentice

Collaborations & Networks Sensile Medical AG (Hägendorf, CH): Direct collaboration Zeptosens AG (Witterswil, CH): CTI project Molecular Stamping SRL (Trento, I): EU FP Aplagen GmbH (Baesweiler, D): EU FP6 Dr. R. Unger (Universität Mainz): EU FP6 Prof. E. Fröhlich (Medical University of Graz, Graz, AT): EU FP Prof. J. Vörös (Laboratory for Biosensors and Bioelectronics, ETHZ): CTI project 2007-2009 External Grants received at the EPFL SNF (regular proposal) 2007-2009

CHF 129’979

SNF (regular proposal) 2008-2010

CHF 121’775

SNF (R’Equip) 2007

CHF 86’000

SNF (R’Equip) 2008

CHF 79’590

Prof. P. Muralt (Ceramics laboratory, EPFL): EU FP7 Dr. H. Hall (ETHZ): Informal collaboration Dr. P. Griffiths (Cardiff University, UK): Informal collaboration Prof. G. Borchard (University of Geneva): Informal collaboration

Sensile Medical AG 2008-2011

Dr. A. Pineda-Lucena (Centro de Investigación Príncipe Felipe, Valencia, CHF 520’000 Spain): Informal collaboration

NCCR Nanoscale Science 2009-2012

CHF 240’000

Fondazione Caritro 2008-2011

Teaching Activities CHF 78’375 Sciences du vivant (Life Sciences): Science et génie des matériaux (BA4)

EU FP7 (Mobesens) 2008-2011

CHF 228’750 Matériaux TP II : Science et génie des matériaux (BA4)

EU FP7 (Hiperdart) 2009-2012

CHF 436’179 Materials sciences : Sciences et technologies du vivant (BA6)

CCMX 2007-2010

CHF 180’000 Polymer chemistry and macromolecular engineering: Génie chimique et biologique (MA1), Chimie moléculaire et biologique (MA1), Science et CHF 120’000 génie des matériaux, (MA1).

BASF AG (Ludwigshafen, D) 2007-2008

Precision polymerization and macromolecular engineering: EDMX Fundamentals of Materials Science and Engineering : EDMX

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Group Mischler Stefano Mischler, Senior Scientist Stefano Mischler obtained the diploma in Materials science in 1983 at the Swiss Federal Institute of Technology ETHZ in Zurich. He accomplished his PhD thesis in the field of surface analysis and corrosion at the Materials Department of the Swiss Federal Institute of Technology EPFL in Lausanne in 1988. In the years 1989-1990 he held a postdoctoral position at the United Kingdom Atomic Energy Establishment in Harwell (Oxfordshire) where he developed novel quantification procedures for Auger Electron Spectroscopy and high lateral resolution surface analytical methods for fiber reinforced ceramics. In 1991 he joined the newly created Tribology group at the Laboratory for Metallurgical Chemistry of the EPFL where he developed research activities in the field of wear-corrosion interactions (tribocorrosion) and of tribological coatings. He is currently head of the tribology group and is developing research and training activities in surface science and technology devoted to advanced tribology and corrosion aspects. In 2006 he spent a sabbatical leave of 3 months at the Tokyo Medical and Dental University, Institute of Biomaterials. Keywords: Tribology, Corrosion, Electrochemistry. http://lmch.epfl.ch

2007-2009 Significant Publications J. Stojadinovic, L. Mendia, D. Bouvet, M. Declercq, S. Mischler, “Electrochemically controlled wear transitions in the tribocorrosion of ruthenium”, Wear (2009), Vol 267, 186–194 S. Mischler , “Triboelectrochemical techniques and interpretation methods in tribocorrosion: a comparative evaluation ”, Tribology International (2008), Vol 41, 573-583 J. Stojadinovic, D. Bouvet, M. Declercq, S. Mischler, “Effect of electrode potential on the tribocorrosion of tungsten”, Tribology International (2008), Vol. 42 575– 583 A.Bidiville, M. Favero, P. Stadelmann, S. Mischler, “Effect of surface chemistry on the mechanical response of metals in sliding tribocorrosion systems”, Wear (2007), Vol 263, 207–217 A.Igual Munoz, S. Mischler, “Interactive effects of albumin and phosphate ions on the corrosion of a CoCrMo implant alloy”, Journal of The Electrochemical Society (2007), Vol. 154 C562-C570 A. W Hodgson; S. Mischler; B. Von Rechenberg; S. Virtanen, “An analysis of the in vivo deterioration of CoCrMo implants through wear and corrosion”, Proc. IMechE Part H: J. Engineering in Medicine (2007), Vol 221, 291-303 2007-2009 Awards Professor René Wasserman Price, EPFL Professor René Wasserman Price attributed to S. Msichler for the forefront research work accomplished in the field of wear-corrosion interactions. Best Presentation Award, Japan Society of Corrosion Engineering 2005-01-01 Award for the paper “The inﬂuence of proteins on the fretting–corrosion behaviour of a Ti6Al4V alloy” presented at the Spring Annual Meeting of the Japanese Society of Corrosion Engineering, Yokohama, 2005.

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Research Interests The group is active in the field of advanced tribology as a multi-disciplinary, multi-scale discipline at the interface between material science, mechanics and surface chemistry and physics. Research interest is focussed on the scientific understanding of the interactions between nano-scaled surface features and tribological system behaviour and at developing predictive multiscale models including mechanical, chemical, electrochemical and material factors. This knowledge is exploited to develop innovative materials and processing routes for tailoring surfaces to meet new tribological challenges with special emphasis on smart coatings and in-situ electrochemical surface treatments. The group has developed a particular expertise in the field of tribology in aqueous systems (tribocorrosion) including fundamental and applied aspects in specific areas such as biomedical implants, in-mouth tribology, coatings, components for microelectronics and power plants.

2007-2009 External Grants received at the EPFL CTI 2009-2010

CHF 198’000

CTI 2009-2011

CHF 215’000

Current Group 2 Postdoctoral Fellows 2 PhD Students 1 Engineer 1 Administrative Assistant 2 Visiting Students

Collaborations & Networks Swiss representative in the COST533 action on “Materials for Improved Wear Resistance of Total Artificial Joints” Swiss representative at the International Corrosion Council Member of the steering committee of the Working Party 18 on “Tribocorrosion and Biotribology” of the European Federation of Corrosion Vice-chairman of the Tribology Committee of the CEFRACOR (Centre Français de l’Anticorrosion); until 2008 Member of the steering committee of the SVMT (Swiss Association for Materials Science and Technology) Teaching Activities CORROSION AND MATERIALS PROTECTION (LECTURE, BACHELOR) Ex cathedra course credited with 3 ETCS credits and mandatory for 3rd year students of the Materials Science and Engineering section. CORROSION AND MATERIALS PROTECTION (LABORATORY PRACTICE, BACHELOR) Laboratory work course credited with 1 ETCS credit and mandatory for 3rd year students of the Materials Science and Engineering section. TRIBOLOGY (LECTURE, MASTER) Ex cathedra course credited with 2 ETCS credits, optional for master level students of the sections: Materials Science and Engineering, Mechanical Engineering, Life Sciences.

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Computational Solid Mechanics Laboratory Jean-François Molinari, Associate Professor (ENAC) Teaching Professor at Ecole Polytechnique, Paris and Adjoint Associate Prof. at the Johns Hopkins University, MD, USA Jean-François Molinari earned a bachelor’s degree in mechanical engineering at the University of Technology of Compiègne in 1997. He then continued his studies at the California Institute of Technology, where in 2001 he completed a doctorate in aeronautics with a specialty in applied mathematics. From 2000 to 2006 (promotion to tenure in 2006), he was an assistant professor in the Department of Mechanical Engineering at the Johns Hopkins University. In 2005, he was appointed as a professor at the École Normale Supérieure in Cachan (France), and since 2006 has also been a professor at the École Polytechnique in Paris and an associate professor at the Johns Hopkins University. He is a member of several scientific associations such as the American Society of Mechanical Engineers, the American Ceramic Society, and the Metals, Minerals and Materials Society. At EPFL since 01/07/2007 Associate professor Molinari has written and co-authored a good forty cited publications, as well as about ten books, book chapters and international conference proceedings. In 2000, while he was at Caltech, he was awarded the Ernst E. Sechler Memorial Award in aeronautics in recognition of excellence in teaching and research. In 2009, he has been awarded a prestigious ERC-starting grant. Keywords: Solid Mechanics, Mechanics of Materials, Scientific Computing. http://lsms.epfl.ch

2007-2009 Significant Publications Kraft RH, Molinari JF, “A statistical investigation of the effects of grain boundary properties on transgranular fracture”, ACTA MATERIALIA 56(17) (Oct. 2008), 4739-4749 Warner DH, Molinari JF, “Effect of normal loading on grain boundary migration and sliding in copper”, Modelling and Simulation Materials Science and Engineering 16(7) (Oct. 2008), Molinari A, Molinari JF, “Mathematical aspects of a new criterion for ranking scientific institutions based on the h-index”, Scientometrics 75(2) (May 2008), 339-356 Warner DH, Molinari JF, “Deformation by grain boundary hinge-like behavior”, MATERIALS LETTERS 62(1) (Jan. 2008), 57-60 Kraft RH, Molinari JF, Ramesh KT, et al., “Computational micromechanics of dynamic compressive loading of a brittle polycrystalline material using a distribution of grain boundary properties ”, Journal of the Mechanics and Physics of Solids 56(8) (August 2008), 2618-2641 Molinari JF, Molinari A, “A new methodology for rankings scientific institutions”, Scientometrics, 75(1) (2008), 163-174 Molinari JF, Gazonas G, Raghupathy R, Rusinek A, Zhou F, “The cohesive-element approach to dynamic fracture: the question of energy convergence”, International Journal for Numerical Methods in Engineering, 69(3) (2007), 484-503 2007-2009 Awards ERC-STG, European Commission 2009-09-01 Uncovering the Origins of Friction (UFO) 60 months, 1’773’000 euros

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Research Interests Jean-François Molinari, Associate Professor within ENAC and IMX in STI, is the head of the Computational Solid Mechanics Laboratory (LSMS: lsms.epfl.ch). His research expertise is at the interface of Mechanics, Materials Science and Scientific Computing. The core activity of LSMS is to develop robust, physics-based numerical tools that are beneficial to scientific and industrial communities. His research interests and scientific contributions span mechanisms from the nanoscale (deformation in nanostructured materials, nanotribology) all the way to macroscopic lengthscales (asteroid impact, landslides). Examples of current Ph.D thesis within LSMS include blast resistance of concrete structures, grain boundary engineering in ceramic materials, and direct atomistic finite-element coupling for uncovering the origins of contact at the nanoscale.

2007-2009 External Grants received at the EPFL US Army Research Office 2008-2009

CHF 83’208

US Army Research Laboratory 2008-2009

CHF 61’478

Swiss National Science Foundation 2009-1012 Commission Européenne, ERCstg 2009-2014

Current Group 4 PhD Students 3 Postdoctoral Fellows 1 Administrative Assistant 1 Technician Apprentice 2 Adjunct Professors

CHF 248’000 CHF 2’830’000

Collaborations & Networks Collaborators in Past Four Years: O. Allix (ENS Cachan, France), N. Bernstein (Naval Research Laboratory), S. Chen (JHU), W.A. Curtin (Brown), G. Gazonas (ARL), P. Gosselet (ENS Cachan), J.A. Harrison (Naval Academy), T.C. Hufnagel (JHU), K.J. Hemker (JHU), E. Ma (JHU), A. Molinari (Univ. Metz, France), A. Muttoni (EPFL), D.E. Niesz (Rutgers), R. Radovitzky (MIT), K.T. Ramesh (JHU), M.O. Robbins (JHU), S. Schoenfeld (ARL), L. Stainier (Univ. Liège, Belgium). Teaching Activities BA 2 - Mécanique des milieux continus BA 5 - Modélisation numérique des solides et structures MAS 1-3 - Mécanique des solides, chapitres choisis MAS 1-3 - Introduction to multiscale Methods Doct. School ME - Computational and Solid Mechanics Ecole polytechnique Paris - Continuum Mechanics

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Mechanical Metallurgy Laboratory Andreas Mortensen, Full Professor Director of Institute of Materials Andreas Mortensen graduated in 1980 from the Ecole des Mines de Paris and earned his Ph.D. at MIT in 1986. He is currently Professor and director of the Laboratory for Mechanical Metallurgy and, since Jan. 2006, director of the Institute of Materials at EPFL, where he also was dean of doctoral studies from June 2000 to Dec. of 2005. Prior to joining EPFL he was, from 1986 to 1996, a member of the faculty of the Department of Materials Science and Engineering at MIT, where he held the successive titles of ALCOA Assistant Professor, Associate Professor, and Professor. Besides his academic employment, he was a postdoctoral researcher at Nippon Steel in Japan, was invited professor at the Ecole des Mines in Paris, and is a member of several industrial or government committees. He counts since 2002 among ISI’s Highly Cited authors for Materials Science and received the EPFL-wide annual teaching award in 2003 and 2008. Keywords: metallurgy, mechanics, materials processing. http://lmm.epfl.ch/

2007-2009 Significant Publications D. Empl, L. Felberbaum, V. Laporte, D. Chatain, and A. Mortensen , “Dihedral Angles in Cu-1wt. Grain Boundary Triple Line Effects”, Acta Mater. (2009), Vol. 57:2527-2537 F. Diologent, R. Goodall, and A. Mortensen, "Surface oxide in replicated microcellular aluminium and its influence on the plasticity size effect ”, Acta Mater. (2009), Vol. 57:286-294 A. Hauert, A. Rossoll, and A. Mortensen , “Ductile-to-brittle transition in tensile failure of particle reinforced metals ”, J. Mech. Phys. Sol. (2009), Vol. 57:473-499 V. Laporte and A. Mortensen, “Intermediate temperature embrittlement of copper alloys ”, Int. Materi. Rev. (2009), Vol. 54:94-116 L. Weber and R. Tavangar, “Diamond-based Metal Matrix Composites for thermal Management made by liquid Metal Infiltration - Potential and Limits ”, Adv. Mater. Res. (2009), Vol. 59:111-115 J. M. Molina, M. Bahraini, L. Weber, and A. Mortensen , “Direct measurement of drainage curves in infiltration of SiC particle preforms: influence of interfacial reactivity ”, J. Mater. Sci. (2008), 43(15):5061-5067 L. Weber and R. Tavangar, “On the influence of active element content on the thermal conductivity and thermal expansion of Cu-X (X = Cr, B) diamond composites ”, Scripta Mater. (2007), Vol. 57:988-991 R. Mueller, S. Soubielle, R. Goodall, F. Diologent and A. Mortensen , “On the steady state creep of microcellular metals ”, Scripta Mater. (2007), Vol. 57:33-36 2007-2009 Awards Georg-Sachs Preis (Awarded to L.Weber), Deutsche Gesellschaft für Materialkunde. 2009-06-24 For applied research of scientists under age of 40 FEMS Materials Science and Technology Prize (Awarded to L.Weber), FEMS. 2009-09-07 European materials scientists or engineers under 40 in recognition of a significant contribution in Materials Science and Engineering

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Research Interests Our research addresses the science and engineering of structural metallic materials, with particular focus on advanced metallic materials, including metal matrix composites and metal foams. Our activities and interests span the spectrum from materials processing to the exploration of links between the microstructure and the properties of advanced metallic materials, for both structural and functional applications. Our approach is chiefly experimental and touches upon a number of subtopics of materials science, including capillarity, infiltration, powder densification, phase transformations, micromechanics including damage mechanics, advanced characterization, dislocational plasticity and creep, conduction mechanisms, and fracture mechanics.

2007-2009 Patents L.Weber, “Heat sink made from diamond-copper composite material containing Boron and method of producing a heat sink”: US 2007/0042895

2007-2009 External Grants received at the EPFL UMS-CTI 01.10.2004 - 30.09.2007

Current Group 7 PhD Students 2 Engineers 4 Postdoctoral Fellows 2 Technicians 1 Administrative Assistant 1 Senior Scientist 1 Scientific Collaborator

Collaborations & Networks INPG, Grenoble France, Institute of Physics of Materials in Brno, Czech Republic, University of Alicante, Spain, Poly Torino, Italy, U. of Leuven, U. of Karlsruhe, IFAM Dresden, Slovak Acad. Sci., EMPA

Teaching Activities Metals and Alloys (lectures taught by A. Mortensen, associated lab. CHF 514’800 offering coordinated by A. Rossoll)

Industry 01.05.2006 - 30.04.2009

CHF 412’500 Deformation and fracture at low temperature (lectures taught by A. Mortensen and recitations by two doctoral candidates of the laboratory) CHF 112’378 High-temperature deformation and fracture (lectures taught by A. CHF 272’000 Mortensen and recitations by two doctoral candidates of the laboratory)

Industry 01.11.2008 - 31.01.2009

CHF 321’800 Deformation and fracture Laboratory Work (coordinated by A. Rossoll)

FN 01.04.2005 - 31.03.2007

CHF 115’441 Materials laboratory work I (coordinated by A. Rossoll)

FN 01.03.2006 - 30.09.2007

CHF 134’855 Materials for Microtechnology I (co-taught by L. Weber)

FN 01.10.2007 - 30.09.2009

CHF 107’169 Joining of Materials (co-taught by L. Weber)

FN01.06.2008 - 31.05.2010

EU/ESA 01.11.2004 - 31.10.2009

CHF 306’654 Principles of Powder and Densification Processing (co-taught with Prof. H. Hofmann) CHF 112’775 Introduction to materials (co-taught by L.Weber) CHF 203’050 7 Semester Projets (B. Sc.) AY 2008 – 2009 CHF 430’000 4 Semester Projets (M. Sc.) AY 2008 – 2009 CHF 121’600 4 M. Sc. Diploma projects AY 2008 – 2009 CHF 660’700

Collaboration University Tokyo 01.12.2007 - 30.11.2010

CHF 253’000

UMS-CTI 01.10.2007 - 30.09.2010 Novelis-CTI 01.10.2007 - 30.09.2008

FN 01.10.2008 - 30.09.2010 FN 01.04.2009 - 31.03.2011 EXTREMAT 01.12.2004 - 30.11.2008 EuCARD 01.04.2009 - 31.03.2014

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Group Muralt Paul Muralt, Adjunct Professor Scientific-Mathematical gymnasium in Zurich. Studies of physics at ETH ZUrich (1973-78), PhD work at Solid State Physics Institute (ETH) in phase transitions and nuclear magnetic resonance (1978-84). Works on scanning tunneling microscopy - Invention of STP (potentiometry) - at IBM Zurich lab (1984-86), Build up of STM acitvity at Free University of Berlin (C1 position) (1986-87) (C1 position). Development physicist and manager in thin film processing at Balzers AG in Liechtenstein (1987-93). Since 1993 at EPFL, ceramics lab, group leader in thin film and MEMS activities / Since 1999: Privat Docent. Since 2005: Adjunct Professor. Since 2009: Principal editor of J.Materials Research Keywords: thin films, micro systems, nanotechnology, ferroelectrics, piezoelectrics, solid state ionics, dielectrics. http://lc.epfl.ch/

2007-2009 Significant Publications A. Artieda M. Barbieri C. Silviu Sandu P. Muralt, , “Effect of substrate roughness on c-oriented AlN thin films”, Journal of Applied Physics (2009), vol. 105, art. 024504 S. Bühlmann P. Muralt, “Electrical Nanoscale Training of Piezoelectric Response Leading to Theoretically Predicted Ferroelastic Domain Contributions in PZT Thin Films”, Advanced Materials (2008), vol 20; p.3090-3095 G. Deng N. Xanthopoulos P. Muralt, “Chemical nature of colossal dielectric constant of CaCu3Ti4O12 thin film by pulsed laser deposition”, Applied Physics Letters (2008), vol. 92; art.172909 S. Rey-Mermet P. Muralt, “Solid Oxide fuel cell membranes supported by nickel grid anode”, Solid State Ionics (2008), Vol. 179, p. 1497-1500 P. Muralt, “Recent Progress in Materials Issues for Piezoelectric MEMS”, J. Amer.Ceram.Soc. (2008), vol 91, p. 1385-96 P. Muralt, “Ferroelectric thin films: The emancipation of ferroelectricity”, Nature Materials (2007), Vol. 60, p. 8-9 F. Calame P. Muralt, “Growth and properties of gradient free sol-gel lead zirconate titanate thin films”, Applied Physics Letters (2007), vol. 90, art. 062907 G. Deng T. Yamada P. Muralt, “Evidence for the existence of a metal-insulator-semiconductor junction at the electrode interfaces of CaCu3Ti4O12 thin film capacitors”, Applied Physics Letters (2007), vol. 91, art. 202903 2007-2009 Patents E. Milyutin, P. Muralt, “Piezoelectric resonator operating in thickness shear mode”: US prov. pat. appl. 61/085,479 M. Collet, P. Delobelle, Y. Meyer, V. Walter, P. Muralt, J. Baborowski, “Microsystème piézoélectrique pour l’isolation vibratoire active de composants sensibles aux vibrations,”: FR2900144 (A1) P. Muralt, S. Rey-Mermet, J. Baborowoski, “Metallic Supporting Grid for Thin Electrolyte Membrane in Solid Oxide Fuel Cells, ”: EP1798800A1

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Research Interests Current Group Structural and functional analysis of electroceramics (experimental research in properties, modelling, and 2 Postdoctoral Fellows theory), processing of thin and thick ceramic films and bulk ceramics, micro- and nano-fabrication technology 4 PhD Students with ceramics, and fabrication of bulk and MEMS electroceramic components.

2007-2009 External Grants received at the EPFL FNS 2008-2011 FNS 2006-2010 EU FP7 2008-2011 EU FP6 2007-2010 EU FP6 2006-2009

Teaching Activities CHF 156’000 SMX Master Semester 8: Lecture (1 h) and practical work (2 h): Micro and Nano Structuration CHF 155’000 SMX Master Semester 7: Lecture (2 h): Thin Film Growth CHF 500’000 SMX Bachelor Semester 6: Lecture (1 h) and practical work (1h): Surface CHF 1’200’000 Anlysis (emphasis on XPS)

CTI 2006-2008

CHF 760’000 SMT Bachelor Semester 3: Lecture (2h): Materials for Microtechnique part on Ceramics (2/3 of a semester) CHF 356’000

CCEM & Swisselectric 2007-2010

CHF 196’000

Collaborations & Networks Since 1999, I proposed quite a number of European projects together with partners that are mainly from other EU countries. The 9 realized projects since 2000 include academic partners - University of Uppsala (S), Besançon (F), Tours (F), Cranfield (GB), Southampton (GB), Sheffield (GB), Catania (I), Rome (I), Grenoble (F) - Research Institutes: CNRS- FEMTO(F), CEA-LETI (F), SINTEF (No), CNR (I, Catania), Frauenhofergesellschaft IBMT, ISIT (D),NIL (Bukarest, Ro), - Industries: ST Microelectronics (Grenoble, Catania, Tours), Philips (Aachen), Oerlikon-UNAXIS-Balzers (CH), Thales (Paris, Antibes), Ericson, - SME’s: Aixacct (Aachen, D), Vernom (F), IR-Microsystems (CH), ABCD (CH), .... In Swiss projects I have partners within EPFL, and with ETH Zurich (on microSOFC). Furthermore there I have many contacts with the ferroelectric community (organisation of symposia, conferences) mainly with scientists from US (Pennstate, North Carolina, Argon NL, Sandia NL, ...), Japan (Tokyo, Tsukuba, ..), Germany (Aachen, MPI Jülich, MPI Halle), GB (Univ. Sheffield, Leeds, Cranfield), and Slovenia (JSI), ....

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Laboratory of Composite and Polymer Technology Jan-Anders Månson, Full Professor Professor Jan-Anders E. Månson is born in Sweden 1952. He obtained his PhD in Mechanical Engineering from Chalmers University of Technology, Sweden, in 1981. After 5 years as head of the R&D department of Konstruktions-Bakelit AB, Sweden, he was appointed Professor at University of Washington (Chemical Engineering), Seattle in 1987, and at the Royal Institute of Technology (Department of polymer technology), Stockholm in 1989, where he still has an affiliated position. In 1990 he joined EPFL as Professor and Laboratory Director at the Department of Material Science, and served as EPFL vice-president during the period 2004-2008. Professor Månson has over 600 scientific publications and is acting on the editorial board of numerous scientific journals, and founder of the start-up company EELCEE SA. He is member of several foundations and since 2006 chairman of the Sport academy (AISTS). Professor Månson is also member of the Antidoping Swiss, the Swiss Academy of Engineering Sciences (SATW) and Elected member of the World Economic Forum’s Global Agenda Council. Keywords: Composites, Polymers, Processing, Functional Materials. http://ltc.epfl.ch/

2007-2009 Significant Publications Ruggerone et al, “Highly filled Polystyrene-laponite nanocomposites prepared by emulsion polymerization”, Eur. Polym. J. 45, 621 (2009), Rion et al, “Ultra-Light Asymmetric Photovoltaic Sandwich Structures”, Compos. Part A. (2009),

2007-2009 Awards Fondation Haenny, 2007-00-00 Prix Fondation (Plummer) Eurosensors XXII, 2007-09-10 SID, 2008-05-22

Neagu et al, “Micromechanics and damping properties of composites FPCM 9, 2008-07-01 integrating shear thickening fluids”, Compos. Sci. Technol., 69, 515 (2009), Schmidt et al, “Acrylated Hyperbranched Polymer Photoresist for UltraThick and Low-Stress High Aspect Ratio Micropatterns”, J. Micromech. Microeng. 18, 045022 (2008), Ternat et al, “Investigation of the Release of Bioactive Volatiles from Amphiphilic Multiarm Star-Block Copolymers by Thermogravimetry and Dynamic Headspace Analysis”, Macromolecules, 41, 7079 (2008), Bühler et al, “Cellular thermoplastic Composites with microstructural Gradients of Fibres and Porosity”, Compos. Sci. Technol. (2008),

Best poster (Leterrier et al) Plenary (Leterrier) Keynote (Michaud)

2007-2009 Patents Bourban, Michaud, Plummer, Månson et al, “Structures with adaptive stiffness and damping integrating shear thickening fluids”: WO 2009053946 (A2) Leterrier, Månson et al, “Packaging laminate, method for manufacturing of the packaging laminate and packaging container produced there from (joint EPFL-Tetra Pak application)”: WO 2008/122293A1 Bourban, Buehler, Månson et al, “Cellular gradient polymer composites”: WO 2008/007332A1

de Oliveira et al, “Experimental investigation of the effect of the mould thermal expansion on the development of internal stresses during carbon Leterrier, Månson et al, “Hyperbranched polymers for microdevices fibre composite processing”, Composites Part A, 39, 1083 (2008), (joint EPFL-KAIST application)”: US 2008/286152A1; EP 06821377.6; KR 10-2008-7013639 Kirkby et al, “Embedded Shape-Memory Alloy Wires for Improved Performance of Self-Healing Polymers”, Adv. Func. Mater., 18, 2253 (2008), Fischer et al, “What static and dynamic properties should slalom skis possess? Judgments by advanced and expert skiers”, J. Sports Sci., 25, 14 (2007),

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Research Interests The overall research objective of the laboratory is to establish the scientific base for the next generation of materials and processes in the fast-growing fields of polymers and composites. This involves novel approaches to tailoring material systems and process cycles, development of new materials with controlled rheology, solidification kinetics and surface characteristics, process simulation and costing, and quantitative durability analysis for optimal life cycle strategies. Building on its expertise in the advanced processing of thermoset and thermoplastic composites, the LTC is also active in smart composites, biocomposites, nanocomposites, and thin films and devices. The laboratory has a research record in developing novel principles towards costeffective materials and manufacturing as well as building unique additional functionality, beyond classical performance criteria. Emphasis is placed on scaling up to an industrial context, particularly in the fields of aerospace, automotive, building, medical, electronics and sports.

2007-2009 External Grants received at the EPFL SNF (4 projects) 2007-2009

CHF 361’878

Industry (5 projects) 2007-2009

CHF 800’199

EU (FP6 & FP7), ESA (7 projects) 2007-2009

CHF 1’109’454

CTI + Industry cash (5 projects) 2007-2009

CHF 1’329’201

CCMX, OFEN (2 projects) 2007-2009

Current Group 4 Senior Scientists 2 Visiting Students 7 Engineers 16 PhD Students 3 Administrative Assistants 7 Postdoctoral Fellows 1 Lecturer

CHF 264’000

Collaborations & Networks INDUSTRY: Alinghi; Applied Materials; Arkema, Bobst; Brugg Cable; CEA-LETI; CSEM; Debiotech; Decision; Dynetix; Essilor; Fiberforge; Ford; Hydroptère; Nestlé; Perstorp; Philips; Quadrant; Ruag; Samsung; SNECMA; Solar Impulse; Solvay-Solexis; Swisspor; Unaxis; VHF Technology; Volvo ACADEMIA: EMPA; EPFL-PVLAB, LBO, IOA; CHUV; ETHZ-LTR, IMES, IMRT; HEIG-VD; EAMF; ESPCI, INSA-Lyon; KAIST; Oregon State U; Politecnico Torino; U Delaware; U Illinois; U Latvia; U Leuven; U Nottingham; U Oxford The laboratory additionally has over 50 project partners around the world.

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Teaching Activities BACHELOR: Technologie des matériaux, Rhéologie, Résistance des matériaux, Matériaux Microtechnique II, Composites Polymères (TP), Technologie et mise en œuvre des Polymères (TP), Polymères, structures, propriétés, Matériaux TP II MASTER: Composites Technology, Matériaux pour le sport, Life Cycle Engineering of Polymers, Recyclage des matériaux, Polymer morphological characterization techniques, Techniques d’Assemblage POST-GRAD: EPFL Doctoral School (Modeling of advanced composites; Science and Technology of UV-Induced Polymerization); Master of Advanced Studies in Sport Administration and Technology

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Computational Materials Laboratory Michel Rappaz, Full Professor Honorary professor at the University of Queensland PhD in solid state physics at EPFL (1979) - Post-doc at Oak Ridge National Laboratory (1979-80) - Research fellow at IMX-EPFL (198182) - Project leader Bonnard-Gardel Eng. Consulting (1982-84) - Group leader at IMX-EPFL (1984-90) - Adjunct professor at IMX-EPFL (1990-2003) - Full Professor (2003 - ) at EPFL and head of the Computational Materials Laboratory of IMX. Main axis of research: connection between macroscopic aspects of solidification (heat and mass transfer) and microscopic aspects of microstructure and defect formation, processes, modelling (FEM, FDM, FVM, CA, DEM, phase field, etc.), experimental investigations and validations. Commercialisation of some of these developments integrated within a commercial code distributed by a spin-off company founded in 1991 (Calcom SA), which has joined the French ESI group at the end of 2002. Initiator in 1992 of an annual solidification course which has been attended by more than 600 participants from all over the world. Two monography books, more than 300 papers, H-32 index factor, Highly-cited author of ISI. See awards list below. Keywords: solidification, phase transformations, modelling, microstructures, defects http://lsmx.epfl.ch/

2007-2009 Significant Publications M.D. Asta, C. Beckermann, A. Karma, W. Kurz, R. Napolitano, M. Plapp, G. Purdy, M. Rappaz, R. Trivedi, “Solidification microstructures and solid-state parallels: Recent developments, future directions”, Acta Mater. (2009), 57: 941-71 S. Vernède, J.A. Dantzig, M. Rappaz, “A mesoscale granular model for the mechanical behavior of alloys during solidification”, Acta Mater. (2009), 57:1554–69 E. Boehm-Courjault, F. Gonzales, A. Jacot, F. Kohler, A. Mariaux, C. Niederberger, M. Salgado, M. Rappaz, “EBSD: A Powerful Microstructure Analysis Technique in the Field of Solidification”, J. Microscopy (2009), 233:160–69 F . Kohler , L . Germond , J . Wagnière , M . Rappaz, “Peritectic solidification of Cu – Sn alloys: Microstructural competition at low speed .", Acta Mater. (2009), 57:56-68 C. Niederberger, J. Michler, A. Jacot, “Origin of Intragranular Crystallographic Misorientations in Hot-Dip Al-Zn-Si Coatings”, Acta Mater. (2008), 56:4002-11 F. Gonzales, M. Rappaz, “Grain selection and texture evolution in directionally solidified Al - Zn Alloys”, Met. Mater. Trans. (2008), 39:2148-60 T. Ventura, C.M. Gourlay, K. Nogita, T. Nishimura, M. Rappaz, A. K. Dahle, “The Influence of 0-0.1wt.% Ni on the Microstructure and Fluidity Length of Sn - 0.7 Cu - X Ni”, J. Electronic Mater. (2008), 37:32-39 M. Salgado-Ordorica, M. Rappaz, “Twinned dendrite growth in binary aluminum alloys”, Acta Mater. (2008), 56:5708-18 J.-M. Drezet, O. Ludwig, C. Jaquerod, E. Waz, “Fracture prediction during sawing of DC cast high strength aluminium alloy rolling slabs,”, Inter. J. Cast Metals (2007), 20:163-170 2007-2009 Awards Highly Cited Author, ISI, 2006-09-30 Plenary Lecturer, FEMS 2007-09-30 Plenary speaker at Euromat (about 2000 participants) Prix René Wasserman des matériaux, EPFL 2008-06-30 For the PhD thesis of Stéphane Vernède “A granular model of solidification as applied to hot tearing” Honorary professor, Univ. Queensland, AU 2008-09-30

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Research Interests Phase transformations, in particular from liquid to solid, are of key importance for the processing of materials. The Computational Materials Laboratory (LSMX), formally Pysical Metallurgy Laboratory, focuses most of its activity on multi-scale modelling of solidification processes. Over the past twenty years, it has been a pioneer in the development of tools for coupling the scale of the microstructure with that of processes. These tools have been integrated into a homemade software, CalcoSoft, and into ProCast, both marketed and supported by a spin-off company, Calcom, founded in 1991 and now part of the French group, ESI. Presently, the laboratory focuses most of its activity on the prediction of two major defects of solidification processes, namely porosity and hot tearing, in order to improve the quality of cast components. Fundamental studies at the level of microstructure, e.g., the growth of peritectics at low growth rate or the selecdtion of dendrite growth directions, are also of key interest to the laboratory. We privilege an approach combining experimental validations (e.g.,Bridgman or directional solidification, DSC) and advanced characterisation techniques (e.g., X-ray tomography, EBSD) with modelling tools such as phase field, cellular automata, inverse methods, finite elements/differences methods. Most of the projects are conducted in close connection with industrial partners.

Current Group 1 Postdoctoral Fellow 1 Administrative Assistant 2 Senior Technicians 3 Scientific Collaborators 13 PhD Students 1 Scientist

2007-2009 External Grants received at the EPFL Swiss National Fund, 2008-10 STI Seed Money, 2007-09 Snecma-Cifre, 2009-12 IMPRESS EU Project, 2004-09 CCMX - MERU, 2008-11 Calcom-ESI 2006-09 Asulab 2008-12 Arcelor-Mittal, 2007-09 Alcan-CRV, 2009-12

Teaching Activities CHF 215’000 - Programming (bachelor 1 and 2, MX, 40 students) - Mechanics of continuus media (bachelor 3, MX, 25 students) CHF 110’000 - Phase transformations I (bachelor 5, MX, 25 students) - Phase transformations II (bachelor 6, MX, 25 students) (+salary PhD student) CHF 120’000 - Modelling in materials science (bachelor 6, MX, 25 students) - Metal Forming (bachelor 4, GM, 70 students) CHF 406’000 - Solidification (master, optional, MX, 10 students) CHF 828’000 - Modelling of materials processing and microstructures (master, optional, MX, 6 students) CHF 240’000 - Modelling as a complementary technique to experiment (PhD, EDMX, (+salary PhD student) CHF 50’000 10 students) - Solid-liquid phase transformations (PhD, EDOC, 6 students) CHF 147’000 - Introduction to materials science (bachelor 1, MX and ME, 180 CHF 285’000 students, starting 2009) - Introduction to materials science (bachelor 2, EL and MT, 180 students, starting 2010)

Collaborations & Networks - Prof. Jonathan Dantzig, Univ. Illinois, Urbana-Champaign, USA - Prof. Alain Karma, Northeastern Univ., Boston, USA - Prof. Peter Voorhees, Northwestern, Evanston,USA - Dr Mathis Plapp, Ecole Polytechnique, Paris, France - Prof. Arne Dahle, Univ. Queensland, Brisbane, Australia - Prof. Michel Suéry, Inst. National Polytech. Grenoble, France - Dr Charles-André Gandin, Ecole des Mines de Paris, Sophia-Antipolis, France - Prof. Helena Van Swygenhoeven, PSI, Switzerland - Prof. Marco Stampanoni, PSI, Switzerland - Prof. S. Momjan, Univ. Geneva, Switzerland - Dr A. Hessler, CIME-EPFL, Switzerland - Prof. J.-F. Molinari, ENAC-EPFL, Switzerland European Solidification Network - METCOMP (ESA project) IMPRESS (EU Project) - CCMX

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Construction Materials Laboratory Karen Scrivener, Full Professor Director CCMX, Chair of CIME executive committee, Member EPFL academic promotions committee Professor Karen Scrivener graduated from University of Cambridge in 1979 in Materials Science. She went on to do a PhD on “The Microstructural Development during the Hydration of Portland Cement” at Imperial College, London completed in 1984. She remained at Imperial College until 1995 as Royal Society Research Fellow and then lecturer, heading the Cement and Concrete Group in the Department of Materials. In 1995 she joined the Central Research Laboratories of Lafarge near Lyon in France as Head of research on Calcium Aluminate cements and expert of concrete durability in general. In March 2001 she was appointed as Professor and Head of the Laboratory of Building Materials, Department of Materials at the Swiss Federal Institute of Technology at Lausanne (EPFL, Ecole Polytechnique Fédérale de Lausanne), Switzerland. She created and is co-ordinating NANOCEM – the industrial-academic research network on cement and concrete which brings together 15 industrial and 24 academic partners. She is Editor-in-Chief of the leading academic journal in the field – Cement and Concrete Research. Keywords: Cement, Concrete, Microscopy. http://lmc.epfl.ch/

2007-2009 Significant Publications Bishnoi S., Scrivener, K.L., “Studying nucleation and growth kinetics of alite hydration using μic”, Cement and Concrete Research (2009 sept) Shashank Bishnoi, Karen Scrivener, “µic: A new platform for modelling the hydration of cements”, Cement and Concrete Research (2009 April ), 266-274 Viviani, M., Glisic, B., Scrivener, K.L., Smith, I.F.C., “Equivalency points: Predicting concrete compressive strength evolution in three days”, Cement and Concrete Research (2008 Sept ), 10701078 Schmidt, T; Lothenbach, B; Romer, M; Scrivener, K; Rentsch, D; Figi, R, “A thermodynamic and experimental study of the conditions of thaumasite formation”, Cement and Concrete Research (2008 March ), 337-349 Lothenbach, B; Le Saout, G; Gallucci, E; Scrivener, K , “Influence of limestone on the hydration of Portland cements”, Cement and Concrete Research (2008 July ), 848-860 Gallucci, E, Scrivener, K., Groso, A., Stampanoni, M, Margaritondo, G., “3D experimental investigation of the microstructure of cement pastes using synchrotron X-ray microtomography (µct)”, Cement and Concrete Research (2007 March), 360-368 Benhaha, M., Gallucci, E., Guidoum, A, Scrivener, K.L., “Relation of expansion due to alkali silica reaction to the degree of reaction measured by SEM image analysis”, Cement and Concrete Research (2007 August ), 1206-1214 Gallucci, E, Scrivener, K., “Crystallisation of calcium hydroxide in early age model and ordinary cementitious systems”, Cement and Concrete Research (2007 April), 492-501 2007-2009 Awards Dykerhoff Prize, Dykerhoff Foundation an endowment of 30,000 EURO in appreciation of pioneering contributions to research or professional achievements in the invention and/or development of application or manufacturing processes in the field of hydraulic binding agents

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Research Interests Our research interests concern all aspects of the materials science of cementitious materials. We combine advance microstructural characterisation techniques with modelling tools to understand the micro and nanoscale mechanisms governing the performance of concrete. Much of our works in directed to increasing the sustainability of cementitious materials which are the most used materials in the world and due to the enormous volumes involved account for 5-8% of man-made CO2 emissions. We have several projects concerned with understanding the mechanisms of hydration (the chemical process of reaction between cement and water which leads to setting and hardening). Here we have developed a powerful modelling platform capable of simulating the reaction of many millions of particles in a few hours. On the experimental side we employ scanning electron microscopy; X-ray diffraction, isothermal calorimetry, etc to follow the progress of the reaction and the development of microstructure. We are also developing models to link microstructure to mechanical properties. Other projects concern the study of degradation reactions which may affect concrete during its service life, in particular we have long running programme in association with the Federal Authorities to predict the progress of Alkli Silica Reaction with is causing expansion of a number of Swiss Dams.

2007-2009 External Grants received at the EPFL SIKA Technology AG, 6340 Baar 2005-2009

CHF 340’000

OFEG (Ofice fédéral des eaux et de la géologie) Bienne 2005-2009

CHF 360’000

LAFARGE Aluminates, 75016 Paris 2006-2009

CHF 54’000

Holcim Group Support Ltd, 5113 Holderbank 2007-2011

CHF 480’000

Current Group 1 Senior Scientist 2 Engineers 1 Senior Technician 1 Technician 3 PhD Students (external) 10 Research Associates 1 Master Student 4 Scientists

GCC Technology and Processes SA, 1400 Yverdon-les-Bains 2005-2009 CHF 80’000 Fond National Suisse 2008-2010

CHF 456’263

Fond National Suisse 2009-2012 EU- Marie Curie programme 2006-2010 Collaborations & Networks I founded the Nanocem consortium, which is an independent IndustrialAcademic Partnership for fundamental research on cementitious materials. This brings together 15 industrial (including the top 5 cement companies worldwide) and 23 academic partners in Europe. This consortium is now co-ordinating around 30 Projects, including 5 in my laboratory. Another important on-going collaboration is with a University in Cuba, with whom we are developing low cost substitutes for conventional cement. This work has been supported by 2 successive grants from the SNSF under their programme for partnerships with developing countries. On a less formal level we have a wide network of contacts in North America, China, India and South Africa.

Teaching Activities Construction Materials for 1st year Civil Engineers lectures plus practical course about 90 students Construction Materials for 3rd year Materials Scientists lectures plus practical course about 25 students Advanced Cementitious Materials optional Master course for Materials Scientists 5-10 students Doctoral Course in cementitious Materials around 20-30 students including external

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Ceramics Laboratory Nava Setter, Full Professor Director of Doctoral School of Materials Education: 1980 PhD (Solid State Science) Penn. State Univ., USA 1976 MSc (Civil Engineering) Technion, Israel Professional experience: 2007 Visiting Prof, Tokyo Inst. Tech., Japan (Spring). 1999 Visiting Prof, Weizmann Inst., Israel (Winter), 1996-2002 Affiliated prof Micro Eng. Dept., EPFL, 1992- Full prof MS&E, EPFL, 1989- Assoc prof and director of the Ceramics Lab, EPFL, 1983-1989 Researcher and then Head of the ElectroCeramics Lab., Haifa, Israel, 1980-1983 Post-doc: Penn State / Oxford UK and chemistry Dept., Uni. Geneva, Switzerland, 1973-1980 Research asst Penn State USA, Technion Israel. 1970-1973 temp. jobs, private & public eng. companies. Academic Service: 2007- Director, doctoral school - materials, EPFL. 2004- Member, faculty promotion comm., EPFL. 2002-2008 Member of the EPFL Research commission. 1996-1998 Head of the MS&E Department, EPFL. 1994-1996 Head, Academic committee, MS&E, EPFL. Keywords: ceramics, functional materials, piezoelectrics, ferroelectrics, electroceramics. http://lc.epfl.ch/

2007-2009 Significant Publications Yamada T, Sandu CS, Gureev M, Sherman VO, Noeth A, Muralt P, Tagantsev AK, Setter N , “Self-Assembled Perovskite-Fluorite Oblique Nanostructures for Adaptive (Tunable) Electronics ", Advanced Materials (2009), V. 21, pp.1363-1367 A Noeth, T Yamada, AK Tagantsev, N Setter, “Electrical tuning of dc bias induced acoustic resonances in paraelectric thin films", J. App. Phys. (2008), V.104(094102) I. Stolichnov, S. Riester, J. Trodahl, N. Setter , “Non-volatile ferroelectric control of ferromagnetism in (Ga, Mn)As", Nature Materials (2008), V. 7 (pp. 464-467) J. Wang, C. S. Sandu, E. Colla, Y. Wang, W. Ma, R. Gysel, H. J. Trodahl, N. Setter, M. Kuball, “Ferroelectric domains and piezoelectricity in monocrystalline Pb(Zr,Ti)O3 nanowires", Appl. Phys. Lett. (2007), V.90(133107) Sherman, VO; Tagantsev, AK; Setter, N, “Model of a low-permittivity and high-tunability ferroelectric based composite", J. Appl. Phys. (2007), V.90(162901) Hollenstein, E; Damjanovic, D; Setter, N, “Temperature stability of the piezoelectric properties of Li-modified KNN ceramics", J. EUR. CER. SOC. (2007), V.27(pp.4093-4097) Gerra, G; Tagantsev, AK; Setter, N, “Ferroelectricity in asymmetric metal-ferroelectric-metal heterostructures: A combined first-principles-phenomenological approach", Physical Rev. Lett. (2007), V.98 (207601) M. Davis, M. Budimir, D. Damjanovic, N. Setter, “Rotator & extender ferroelectrics: Importance of the shear coeff to the piezoelectric properties of domain-engineered crystals & ceramics", J.Appl.Phys. (2007), V.101(054112) 2007-2009 Awards Fellow, IEEE 2007-01-01 Academician, World Academy of Ceramics 2007-01-01

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Research Interests Research at the Ceramics Laboratory is centered on the science and technology of functional ceramics. In the focus are piezoelectric and related materials: ferroelectrics, dielectrics, pyroelectrics. Other classes of electroceramics, such as conductive and semi-conductive ceramics are studied too. The work includes fundamental and applied research and covers the various scales from the unit cell to the final devices. Key competences in the lab are in the following areas: Structural and functional analysis of electroceramics (experimental research in properties, modelling, and theory), processing of thin films, micro- and nanofabrication technology with ceramics, and fabrication of bulk and MEMS electroceramic components.

Current Group 2.5 Senior Scientists 5 Postdoctoral Fellows 5 PhD Students 2 Technicians 4 Master Students

My individual research interests: (1) Ferroelectrics, and piezoelectrics: in particular effects due to interfaces, size effects, domain wall phenomena.Structure-property relations in the above. Pursuit of new applications based on the above. (2) Science learning & science teaching - investigating mechanisms to enhance the above and implementing them.

2007-2009 External Grants received at the EPFL Swiss Foreign Ministry (SDC) 2009-2012

CHF 340’800

SNF 2006-2010

CHF 940’000

NCCR-SNF 2001-2009

CHF 400’000

EU PF7 2009-2011

CHF 1’050’000

EU PF7 2009-2010

CHF 100’000

EU PF6 NoE 2005-2010

CHF 800’000

EU PF6 2008-2010

CHF 160’000

EU PF6 2005-2008

CHF 2’300’000

EU COST 2006-2009

CHF 150’000

EPF council 2006-2008

CHF 120’000

CTI 2006-2009

CHF 284’000

Collaborations & Networks Formal collaborations with various universities, research institutes, and industries through research projects of the EU. Networks: Participation in the MIND NoE (piezoelectrics) of the EU and in the COST 539 project in which some 25 European universities are members. Teaching Activities Bachelor courses: Ceramics - structures, ceramics - properties, functional materials in communication systems.

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Group Van Swygenhoven Helena Van Swygenhoven, Adjunct Professor (Paul Scherrer Institute) Helena Van Swygenhoven studied physics in the Free University of Brussels, was research assistant in the University Center of Limburg, received her PhD degree in physics from the Central Jury in Belgium on radiation damage in materials (1983). She then went back as postdoctoral fellow at the Free University of Brussels. After a professional break for motherhood (1989-1991), she joined the Fusion Technology Division at the Paul Scherrer Institute with a Marie-Heim Voegtlin stipendium from the Swiss National Science Foundation. She moved to the Neutron Spallation Source department, starting a research group in the field of nanostructured materials (1993), involving as well experimental research as computer modelling. Keywords: http://lmm.epfl.ch/, http://mss.web.psi.ch

2007-2009 Significant Publications S.Chiesa, P.M. Derlet, S.L. Dudarev, H. Van Swygenhoven, “Atomistic calculation of elastic constants of alpha iron containing point defects ba means of magnetic interatomic potential”, Jnl. Nucl.Mat. (2009), 386 (2009)49 A. Elsener, O. Politano, P.M. Derlet, H. Van Swygenhoven, “Variable-chage method applied to to coupled grain boundary migration in the presence of oxygen”, Acta Mat. (2009), 57 (2009) 1988 E. Bitzek, C. Brandl, D. Weygand, P-M- Derlet, H. Van Swygenhoven, “Atomistic simulation of dislocation shear loop interacting with grain boundaries in nc- Al”, Modelling and Simulation in Material Science and Engineering (2009), 17 (2009) 55008 V. Vidal, L. Thilly, S. Van Petegem, U. Stuhr, F. Lecouturier, P.O. Renault, H. Van Swygenhoven, “Plasticity of nanostructured Cu-Nb-based wires: strengthening mechanism revealed by in-situ deformation with neutrons”, Scripta Mat. (2009), 60 (2009) 171 S. Van Petegem, S. Brandstetter, R. Maaß, A. M. Hodge, Bassem S. El-Dasher, J. Biener, B. Schmitt, C. Borca, H. Van Swygenhoven, “On the microstructure of nanoporous gold: an x-ray diffraction study”, Nano Letters (2009), 9 (2009) 1158 S. Van Petegem, S. Brandstetter, B. Schmid, H. Van Swygenhoven, “Creep in nanocrystalline Ni during X-ray diffraction”, Scripta Mat. (2009), 60 (2009) 297

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Research Interests Synergies between in-situ X-ray/neutron diffraction experiments and computational material science with emphasis on the following topics. Development and use of miniaturized testing techniques for ex-situ and in-situ mechanical testing in the Swiss light source (SLS) allowing to address structural/functional and mechanical properties of materials - small scale plasticity in confined systems for micro/nanotechnology - metallic alloys with nanoscaled microstructures - electrical resistivity in confined systems Development and use of in-situ measurement techniques at the SLS and SINQ addressing the role of residual stresses in the performance of advanced alloys with complex multiphase microstructures of industrial relevance. Performance of large scale atomistic simulations (molecular dynamics, ab-initio) to guide experiments investigating dynamical processes in metallic materials. Development of computational tools to be used as bottom-up approach for the interpretation of monochromatic powder diffraction and white beam Laue diffraction patterns. Providing user support for external users of POLDI. Performance of large scale atomistic simulations (molecular dynamics, ab-initio) providing synergies with the in-situ experiments investigating dynamical processes in metallic materials.

Collaborations & Networks Prof. Van Swygenhoven is Group Leader of Materials Science and Simulation at the Paul Scherrer Institute. Committees - Elected by the EC-commission as a member of the External Advisory Group (EAG) of the NMP program with respect to FP7 and FP8. - Elected member of the International Advisory Committee of the International Risø Symposium on Materials Science - Elected member of the PSI research commission (FOKO) - Member of the Foundation and member of the Hiring commission for three Directors of the Interdisciplinary Center for Advanced Materials Modelling (ICAMS), which will be attached to Ruhr-University Bochum, Germany (2007). - Member of the hiring commission for the Professor in Experimental Condensed Matter Physics at ETHZ and Head of Laboratory for Neutron Scattering at PSI (2008) - Member of Expert Evaluators Panel for FP7-NMP-2007-SMALL-1, Strategic objective NMP2007-2.5-2-Modelling of microstructural evolution under work conditions and in materials processing (May 2007). - Member of the reviewing commission of the proposals for beam time at the instruments at FRM II Editor activities Volume editor in the MRS Bulletin 2009, Atomistic simulations of nanomechanics. Member of the Editorial Advisory Panel of the journal “Materials Today”, Elsevier, since Jan 2007. She has been co-organizing several international conferences, workshops to promote a synergy between modeling, theory and experiment and is a chair of the MRS Fall Meeting 2006, and vicechair of the International Conference of Strength of Materials (ICSMA) Teaching Activities Doctoral school EPFL international summerschools in Austria, Hamburg, Italy

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Laboratory of Optoelectronics of Molecular Materials Libero Zuppiroli, Full Professor Born 1947-07-14. Origin Italian. Studies in France. Telecommunications engineer, Paris, 1969. Specialisation in Solid State Physics, Orsay, 1970. PHD Thesis, Orsay, 1976. Scientist at Commissariat à l’Energie Atomique, Saclay, 1976-1985. Associate Professor à l’Ecole Polytechnique de France, 1985-1990. Professor at EPFL, 1990Keywords: Optoelectronics in molecular materials, Hybrid polymer films for photonics, Self-assembled monolayers, Charge transport theories in organic semiconductors. http://lomm.epfl.ch/

2007-2009 Significant Publications Nicolet, O., Huber, S., Lovey, C., Chappellet, S., Perrenoud, J., Pauchard, M., Ferrini, R. and Zuppiroli, L, “Quantum yield measurement of fluorescent zeolite nanopigments”, Advanced Functional Materials (2009), 19 pp. 1877 Zuppiroli, L., Bussac, M.-N. and Grimm, C. , “Traité de la lumière”, Book in french, 810 exemplars sold in 4 months (2009), 1-481 El-Kallassi, P., Balog, S., Houdré, R., Balet, L., Li, L., Francardi, M., Gerardino, A., Fiore, A., Ferrini, R. and Zuppiroli, L. , “Local infiltration of planar photonic crystals with UV-curable polymers”, Journal of the Optical Society of America B (2008), 25(10) pp. 1562 Konezny, S.J., Bussac, M.N. and Zuppiroli, L. , “Charge transport mechanisms in microcrystalline silicon”, Applied Physics Letters (2008), 92 pp. 012107-1 - 3 Zuppiroli, L., “Le traité des couleurs de Goethe et la science d’hier et d’aujourd’hui”, Book chapter in french (2008), 3-36 El-Kallassi, P., Ferrini, R., Zuppiroli, L., Le Thomas, N., Houdré, R., Berrier, A., Anand, S. and Talneau, A. , “Optical tuning of planar photonic crystals infiltrated with organic molecules”, Journal of the Optical Society of America B (2007), 24(9) pp. 2165 Picon, J.D., Bussac, M.N. and Zuppiroli, L. , “Quantum coherence and carriers mobility in organic semiconductors”, Physical Review B (2007), 75 pp. 235106 von Mühlenen, A., Errien, N., Schaer, M., Bussac, M.N. and Zuppiroli, L. , “Thermopower measurements on pentacene transistors”, Physical Review B (2007), 75(11) pp. 115338 2007-2009 Awards Prix Arnulf-Françon of the French Optical Society, best book in optics. 2009-06-19 The committee was impressed by the remarkable aesthetics, the original pedagogical style and the powerful impact of this work (the book Traité de la lumière) that will contribute to the readers love of optics and its history. 2007-2009 Patents Ferrini, R., Fürholz, U., Nicolet, O., Pauchard, M., Perrenoud, J. and Zuppiroli, L. (2008) , “Optisches Element und Verfahren zu seiner Herstellung (Optical element and methods for its fabrication)”: # EP08164280.3

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Research Interests - Charge transport in organic materials (theory) - Photonics (experiments : light emission, light extraction, fluorescence) - Organic light emitting diodes (OLED’s) - Organic field effect transistors (OFET’s) - Infiltration of photonic crystals with organic molecules - Color changing films for lighting applications

Current Group 1 Scientific Collaborator 1 Engineer 2 Senior Technicians 0.5 Administrative Assistant 3 Postdoctoral Fellows 3 PhD Students 1 Master Student

Collaborations & Networks 2007-2009 External Grants received at the EPFL Within EPFL, M. Graetzel (OLED’s and fluorescence), M.A. Ionescu and Swiss National Center of Competence and Research (NCCR) in Quantum Photonics 2005-2009 CHF 170’000 J. Brugger (OFET’s), O.J.F. Martin and R. Houdré (Photonics). With industries, Ilford; Marly, Artemide, Milano; Ciba Geigy, Basel NSF no 200021-111856 Hybrid Polymer films for light propagation, confinement and modulation 2007-2008 CHF 95’348 (Color changing films for lighting applications). Saint Gobain Recherche (OLED’s). NSF no 200020-121715 Propriétés optoélectroniques de semiconducteurs organiques 2008-2010 CHF 403’269 Ecole Polytechnique de France, M.N. Bussac (Charge transport in organic media, theory). NSF no 200020-121554 Films hybrides à base de polymères pour la Université de Saint Etienne, A. Tishchenko (Light extraction from propagation, le confinement et la modulation de la lumière 2008-2010 CHF 223’356 optoelectronic devices, theory). National Network, NCCR Quantum Photonics. NSF no 2000020-113254 Optoelectronic properties of organic semiconductors 2007-2008 CHF 184’852 European Network, ePIXnet, European Network of Excellence on Photonics Integrated Components and Circuits. ePIXnet, European Network of Excellence on Photonics Integrated Components and Circuits 2007-2008 CHF 14’500 Teaching Activities CTI no 8184.1 New Color Changing Films for Lightning Applications 2007-2008 CHF 161’520 + 35’000 First year course INTRODUCTION TO MATERIALS SCIENCE (3 hours per week during the whole year, about 360 students this year) Contract EPFL - Ilford, attribution by Ilford of 350 square meters labs on the industrial site of Marly (labs space, running costs and subventions of Master course : QUANTUM MECHANICS IN VIEW OF meals for EPFL collaborators) 2007- CHF 289’500 APPLICATIONS I (3 hours per week, one semester, 21 students in 2009) -Direct industrial contract, Saint Gobain 2007-2008

CHF 126’000 Master course : QUANTUM MECHANICS IN VIEW OF APPLICATIONS II (3 hours per week, one semester, 10 students in 2009).

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Institute of Microengineering

Photovoltaics and Thin Film Electronics Laboratory Christophe Ballif, Full Professor 1 1.10.2004 Institute of Microengineering IMT, (EPFL, University of Neuchâtel until 1.1.2009). Full professor, Director of the PV-Lab. 5.2003 - 9. 2004 Swiss Federal Institute for Material Research (EMPA), Thun. Head of the ‘nanofactory lab’ . 2000 – 4.2003 Fraunhofer Institute for Solar Energy Systems (ISE), Industry Laboratory, Gelsenkirchen, Germany. 3. 2001 Weizmann Institute, Rehovot, Israel. Invited scientist. 1999 – 2000 National Renewable Energy laboratory (NREL), Golden, CO, USA. Postdoc. 1994-1998 Ecole Polytechnique Fédérale de Lausanne (EPFL). Research assistant and thesis.(Prof. F. Lévy, supervisor). At EPFL since 2009/Transfert from Unine Keywords: Photovoltaics, thin film Silicon, amorphous silicon, heterojunction cells, lamination. http://pvlab.epfl.ch/

2007-2009 Significant Publications G. Bugnon, A. Feltrin, F. Meillaud, J. Bailat, and C. Ballif, “Influence of pressure and silane depletion on microcrystalline silicon material quality and solar cell performance”, Journal of Applied Physics (2009), 064507 R. Bartlome, A. Feltrin, and C. Ballif, “Infrared Laser-Based Monitoring of the Silane Dissociation during Deposition of Silicon Thin Films”, Applied Physics Letter (2009), 201501 D.Dominé, P.Buehlmann, J. Bailat, A. Billet, A. Feltrin, and C. Ballif, “Optical management for high-efficiency thin-film silicon micromorph solar cells with an in situ silicon oxide based intermediate reflector”, Rapid Research Letter (2008), 163 F.-J. Haug, T. Söderström, O. Cubero, V. Terrazzoni-Daudrix, C. Ballif , “Plasmonic absorption in textured silver back reflectors of thin film solar cell ”, Journal of Applied Physics (2008), 064509 S. De Wolf, S. Olibet, and C. Ballif, “Stretched-exponential a-Si:H / c-Si interface recombination decay”, Applied Physics Letter (2008), 32101 S. Olibet, E. Vallat-Sauvain, and C. Ballif , “A model for a-Si:H/c-Si interface recombination based on the amphoteric nature of silicon dangling bonds ”, Physical Review B (2007), 76 035326 J. Steinhauser, S. Faÿ, N. Oliveira, E. Vallat-Sauvain, and C. Ballif, “Transition between grain boundary and intragrain scattering transport mechanisms in boron-doped zinc oxide thin films ”, Applied Physics letters (2007), 142107 S.Hoffmann, F.Östlund, J.Michler, H.J.Fan, M. Zacharias, S.H.Christiansen and C. Ballif , “Fracture strength and Young’s modulus of ZnO nanowires”, Nanotechnology (2007), 205503 2007-2009 Awards Best technical poster, OFEN 2007-05-19 V. Terrazzoni-D., Th. Söderström, Best technical poster, 7thNational PV, conf. Luzern 2007 Swiss-Electric research award , Swiss-Electric research 2007-09-25 - S. Olibet, Swiss-Electric research award 2007 (CHF 25’000) Best visual presentaion category crystalline Si, EU-PVSC conference 2007-09-27 L. Fesquet, best visual presentation, category c-Si, 22nd EUPSCV Milano 2007 best young scientist oral contribution, IEEE 2008-05-21 - G. Bugnon, best young scientist oral contribution, 31st IEEE PVSC, San Diego 2008 Prix Nexans, Nexans 2009-10-19

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N. Wyrsch, Prix Nexans 2007 (CHF 20’000)

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Research Interests The focus of the the lab is the developpement of new prrocesses and device structures for photovoltaics, ranging from material aspects to full demonstrators. Key points are the the realisation of high efficiency thin film silicon solar cells (based on a-Si and microcrystalline Si) on glass and plastic substrate as well as the physical properties and manufacturing of high efficiency heterojunction crystalline Si solar cells(a-Si/c-Si). A special focus is set on the development of transparent conductive oxydes (TCO) and advanced light trapping structures for thin film Si solar cell and on plasma processes for cell fabrication, including new plasma diagnostic tools and high deposition rate approaches. Encapsulation processes and reliability of PV-Modules, with emphasis on durability of thin film Si modules are also investigated, based on the full infrastructure at the PV-Lab. Finally, thin film electronic devices processing (e.g. TFT) and specialized detectors (e.g. X-Rays) are also considered.

2007-2009 Patents P. Buehlmann, D. Domine, J. Bailat, “Dispositif photoélectrique à jonctions multiples et son procédé de réalisation, pour les cellules en configuration p-i-n, no de dépôt : ”: EP08169424.2, date de dépôt : 19.11.08 T. Söderström, “ Dispositif photoélectrique à jonctions multiples et son procédé de réalisation, pour les cellules en configuration n-i-p”: EP08169423.2 Filed 19.11.08 Olibet, Damon-Lacoste, Ballif, “ Procédé pour limiter la croissance épitaxiale dans un dispositif photoélectrique à hétérojonctions et un tel dispositif photoélectrique ”: EP08163425/Filed 1.9.08 2007-2009 External Grants received at the EPFL Swiss electric research 2007-2009 OFEN 1011091 2008-2011 Industrial research contracts 2007-2012

Current Group 8 Group Leaders 1 Senior Technician 3 Trainees 1 Research Coordinator 5 Scientific Collaborators 6 Engineers 5 Laboratory Assistants 7 PhD Students 2 PhD Students (external) 5 Research Assistants 6 Postdoctoral Fellows 2 Undergraduate Students 1 MD, PhD Student 1 Visiting Student 1 Student Grant-holder

Collaborations & Networks - Involved in several EU consortium, scientific and personal exchange, with several research institutes worlwide (AIST Japan, NREL US, TU Eindhoven NL,...) - Involved in Swiss CCEM-CH project (IMT, EPFL, EMPA) - Involved in a network of compagnies, establishing production plants for low costs thin film silicon modules. Teaching Activities AT Unine (2004-2009), in charge of lectures on a) Semiconductor physics (3rd year), b) Thin film technology (master level), c) Introduction to electronics (1st year)

At EPFL (starting sept 2009), in charge of lectures on a) Fundamentals and processes for photovoltaic devices (Master level, 1st semester), b) CHF 160’000 Opto- and macroelectronic materials (Master level, 2nd semester) CHF 3’000’000 Various lectures on energy on photovoltaics are regularyl given (e.g.organisation of thin Film PV schools) CHF 5’200’000

FN 200021_126926 2009-2011

CHF 272’000

FN 200020-116630/1 2007-2009

CHF 252’000

EU-FP7 N2P 2008-2012

CHF 445’000

EU-FP7 Hesti 2008-2011

CHF 540’000

EnergieNet.Dk 2008-2010

CHF 375’000

CTI 9908.2 2009-2011

CHF 321’000

CTI 8968 2008-2009

CHF 355’000

CTI 8809 2007-2009

CHF 587’000

AxpoNaturstromfonds 2007-2011

CHF 920’000

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Learning algorithms and systems Laboratory Aude Billard, Associate Professor Aude Billard received her B.Sc. (1994) and M.Sc. (1995) in Physics from EPFL, with specialization in Particle Physics at the European Center for Nuclear Research (CERN), a MSc. in Knowledge-based Systems (1996) and a Ph.D. in Artificial Intelligence (1998) from the Department of Artificial Intelligence at the University of Edinburgh. She worked as Research associate (1999-2000) and then as Research Assistant Professor (2000-2004) at the department of Computer Science at the University of Southern California, where she retained an adjunct faculty position to this day. She was then an Assistant Professor at EPFL (2002-2004), where she became Associate Professor in January 2006. Keywords: Machine Learning, Robotics, Mechatronics. http://lasa.epfl.ch/

2007-2009 Significant Publications M. Hersch, F. Guenter, S. Calinon and A. Billard, “Dynamical System Modulation for Robot Learning via Kinesthetic Demonstrations ”, IEEE Transactions on Robotics (2008), vol 24, pp. 1463–1467 A. Billard, S. Calinon, R. Dillmann and S. Schaal, “Robot Programming by Demonstration ”, in Handbook of Robotics, MIT Press (2008), 95-107 M. Hersch and A. Billard, “Reaching with Multi-Referential Dynamical Systems ”, Autonomous Robots (2008), Vol. 25, pp 71-83 S. Calinon, F. Guenter and A. Billard, “On Learning, Representing and Generalizing a Task in a Humanoid Robot ”, IEEE transactions on systems, man and cybernetics, Part B. (2007), Vol. 37, pp 286-298 E. Sauser and A. Billard, “Dynamic Updating of Distributed Neural Representations using Forward Models ”, Biological Cybernetics (2006), vol 95(6), pp 567-588. A. Billard, B. Robins, K. Dautenhahn and J. Nadel, “Building Robota, a Mini-Humanoid Robot for the Rehabilitation of Children with Autism.”, the RESNA Assistive Technology Journal (2006), Vol. 19, pp. 68-88. A. Billard, S. Calinon and F. Guenter, “Discriminative and Adaptive Imitation in Uni-Manual and Bi-Manual Tasks ”, Robotics and Autonomous Systems (2006), vol. 54, pp 370-384 B. Petreska and A. Billard, “Movement Curvature Planning through Force Field Internal Models ”, Biological Cybernetics (03/05/2009), vol: 100, pp. 331-407

2007-2009 Awards Best Paper award - CORES’07, CORES, 2007-11-16. Conference on Computer Recognition Systems (CORES). Basilio Noris, PhD student, received a distinction award for his oral presentation of his work on automatic gaze tracking. CORES brings together researches and provides an international forum for the sharing, exchange, presentation and discussion of original research results in both methodological issues and different application areas of pattern recognition. The conference covers all topics in pattern recognition. ICRA’08 1st Prize - Grand Challenge on Human-Robot Interaction, IEEE Robotics and Automation Society, 2008-05-22. The LASA laboratory won the Grand Challenge on Human-Robot Interaction held during the International Conference Robotics and Automatition (ICRA) in Pasadena, USA. IJCNN’08 Best Student Paper, International Joint Conference on Neural Networks, 2008-06-05. Biljana Petreska received the best student paper award. IJCNN is the premier international conference in the area of neural networks theory, analysis and applications. It is organized by the International Neural Networks Society (INNS) and sponsored jointly by INNS and the IEEE Computational Intelligence Society. Best Paper Award - ROMAN’07, IEEE - ROMAN, 2008-08-01. Best paper award.The ROMAN conference addresses fundamental issues of co-existence of human and intelligent machines such as robots and recent advancements of technological as well as psychological researches on every aspect of interactive communication and collaboration between robots and humans. Interactive communication and collaboration in human/robots as well as human/robot/humans will be crucial issues to enrich our human welfare and happiness in networked society. RobotDalen Prize, RobotDalen, 2008-12-08. Dr. Sylvain Calinon received the Robotdalen Scientific Award for his PhD thesis on Robot Programming by Demonstration conducted at LASA/EPFL from 20032008. The Robotdalen Scientific Award is an international competition for young scientists, with € 20 000 in prize money. Robotdalen (Robot Valley) is a Swedish initiative supporting the development of robotics and automation for the industrial, logistics and healthcare sectors.

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Research Interests Current Group Learning and Dynamical Systems, Neural Computation and Modeling, Human-Machine Interaction, 3 Postdoctoral Fellows Humanoids Robotics, Mechatronics, Design of Therapeutic and Educational Devices. 0.6 Administrative Assistant 7 PhD Students 1 Engineer 1 Scientific Collaborator

2007-2009 External Grants received at the EPFL Swiss National Center of Competence in Research (NCR) on Interactive Multimodal Information Management. IM2. 2006 - 2010 CHF 240,000

Collaborations & Networks International (European Consortiums): - ROBOT-CUB (IP) - FEELIX-GROWING (STREP) - ROBOT@CWE (STREP) - Skin (STREP)

7th Framework Program on Information Society Technologies; EU Commission. Roboskin: Skin-based technologies and capabilities for In Switzerland: safe, autonomous and interactive robots. 2009 - 2012 CHF 795,000 - Swiss National Center of Competence in Research: IM2 - EPFL Robotics Center 6th Framework Program: Cross-Cutting Research Activities; EU Other collaborations with individuals: Commission. TACT, Thought in Action. 2006 - 2008 CHF 388,000 Prof. Tamar Flash, Weizmann Institute, Israel Prof. Jacqueline Nadel, CNRS, France Prof. Robin Murphy, Texas A&M, USA 6th Framework Program on Information Society Technologies; EU Commission. Robot@CWE: Advanced robotic systems in future collaborative working environments. 2006 - 2008 CHF 434,000 Teaching Activities MSC Courses: 6th Framework Program on Information Society Technologies; EU Applied Machine Learning (4 credits): MicroEngineering Section and Commission. Feelix Growing: Feel, interact, express: a global approach Electrical Engineering Section Applied Robotics Practicals (4 credits): to development with interdisciplilnary grounding. MicroEngineering Section 2006 - 2008 CHF 434,000 PhD Courses: 6th Framework Program on Information Society Technologies; EU Machine Learning (4 credits): EDIC & EDPR doctoral programs Commission. Cogniron: The cognitive robotic companion Autonomous Robots (4 credits): EDPR doctoal program 2004 - 2008 CHF 527,000 Seminars in Robotics (2 credits): EDPR doctoral program 6th Framework Program on Information Society Technologies; EU Commission. Robot-Cub: Robotic open-architecture technology for cognition, understanding and behaviors. 2004 - 2009 CHF 860,000

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Robotic Systems Laboratory 1 Hannes Bleuler, Full Professor Director of the Section of Microengineering, President of APEL, President of EPFL Assembly Swiss, Born 19.2.1954 1973-78 ETH Zurich, M.S. in Electrical Engineering 1979-84 Teaching Assistant, Doctorate Student at ETH (Inst. of Mechanics) 1984 Ph.D. thesis in Mechatronics (magnetic bearings, Prof. G. Schweitzer) 1985-87 Research Engineer at Hitachi Ltd, Japan, Mechanical Engineering Research Laboratory; 1987 Invited researcher at the Tokyo Institute of Technology (Precision Mechatronics, Prof. K. Ono) 1988-91 Lecturer and Senior Assistant at ETH ; co-foundation of MECOS-Traxler AG 1991-95 Toshiba Chair of "Intelligent Mechatronics" and then regular Associate Professor at The University of Tokyo (Institute of Industrial Science) 1995 - present Full Professor at EPFL Lausanne on micro–robotics, biomedical robotics; 2000 Co-founder of xitact SA, Morges (robotic surgery instrumentation & simulators) 2002-2006 President Conference of Professors and Lecturers of EPFL, member of Assemblée de l’Ecole 2006 Chairman of ISMB10 (10th International Symposium on Magnetic Bearings, Martigny, Switzerland) 2006 Nomination as member of the Swiss Academy of Technical Sciences (SATW)

2007-2009 Significant Publications R. Gassert, D. Chapuis, H. Bleuler, and E. Burdet, “Sensors for applications in magnetic resonance environments.”, IEEE/ ASME Transactions on Mechatronics (2008), 13(3):335–344 P. Maillard, L. Flaction, E. Samur, D. Hellier, J. Passenger, and H. Bleuler, “Instrumentation of a Clinical Colonoscope for Surgical Simulation”, 30th Annual International IEEE EMBS Conference (2008), pp. 70-73 D. Hellier, E. Samur, J. Passenger, U. Spaelter, H. Frimmel, M. Appleyard, H. Bleuler, and S. Ourselin, “A modular simulation framework for colonoscopy using a new haptic device”, 16th Medicine Meets Virtual Reality Conference (MMVR) (2008), E. Samur, U. Spaelter, L. Flaction, P. Maillard, R. Wuthrich, and H. Bleuler, “Control of a Haptic Interface and a Micromachining Setup with an Open Source Real-Time System”, The 3rd ASME/IEEE International Conference on Mechatronic and Embedded Systems and Applications (2007), Teaching Activities Assembly and robotics Laboratory Work (SMT) Robotics - microrobotics I (SMT SGM) Statics and Dynamics (SMT) Vibrational systems (SMT)

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Keywords: Parallel robots, Frictionless bearings, Nanometric positioning, Medical robotics and instrumentation, Current Group 2 Administrative Assistants Mechatronic design. http://lsro.epfl.ch/ 1 Senior Scientist 5 Scientists Research Interests The Laboratoire de Systèmes Robotiques (LSRO) is a mulitidisiplinary research unit working mostly in the 5 Laboratory Assistants fields of micro-robotics, biomedical robotics, haptics, MRI compatible instrumentation and nanotechnologies. 2 Engineers 11 PhD Students Within the large field of “microrobotics”, we are interested in various small mobile robots, in high precision 3 Scientific Advisers 2 Scientific Collaborators motion control and in contact-free and vacuum compatible devices. 1 Senior Technician Project examples include 2 Technicians - Haptic mini-invasive surgery simulators (Laparoscopy, Hysteroscopy, Radiology, Colonoscopy) 1 Trainee - fMRI compatible haptic devices - Diamagnetic and contact-free devices for sensors or vacuum compatible actuation - Electrostatic Motor for Cesium Atomic Clock (together with Observatoire de Neuchâtel, Professor Thomann, and METAS-office, Berne) - Optical Delay Line for the European Southern Observatory (a project together with the Observatoire de Genève, Prof. Mayor and Didier Queloz, the discoverers of exoplanets) - Spark Assisted Chemical Engraving, a method for 3-D structuring of glass, used e.g. for rapid prototyping of microfluidic elements (together with Professor Christos Comninellis, EPFL)

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Microsystems Laboratory 1 Jürgen Brugger, Associate Professor Vice-Director Institute of Microengineering Juergen Brugger (M.Sc. and Dr.sc. from the University of Neuchatel) joined EPFL in 2002 as tenure-track assistant professor. In 2008 he was appointed associated professor and Vice-director of the Institute of Microtechnology (IMT). Before joining EPFL, he was Research Program Coordinator at the MESA Research Institute of Nanotechnology, University of Twente, The Netherlands, research staff member at the IBM Zurich Research Laboratory, and research fellow at the Hitachi Central Research Laboratory, Tokyo. He works in the field of interdisciplinary and experimental micro and nanotechnologies towards integrated micro/nanosystems. In his research, he combines cleanroom technologies with emerging micro and nanopatterning methods and inkjet printing, to be applied to information technologies and life-sciences. Dr. Brugger has published over 90 peer-reviewed scientific publications. He serves as editorial board member and section editor of the IOP journal "Nanotechnology". He participates in various conference committees such as the IEEE-IEDM, Transducers and MEMS and serves as Chair for the Eurosensors XXIII, Lausanne, 2009. His own laboratory presently consists of 4 postdocs and 7 PhD students. He is co-inventor of about 10 patents and received two IBM research awards. Keywords: MEMS, nanotechnology, inkjet printing. http://lmis1.epfl.ch/

2007-2009 Significant Publications J.Y. Kim, C. Ingrosso, V. Fakhfouri, M. Striccoli, A. Agostiano, M.L. Curri and J. Brugger, “Inkjet-Printed Multicolor Arrays of Highly Luminescent Nanocrystal-Based Nanocomposites”, Small, 5 (2009), 1051-1057 G. Villanueva, O. Vazquez-Mena, C. Hibert and J. Brugger., “Direct Etching of High Aspect structures through a Stencil ”, Proceedings of the 22nd IEEE International Conference on Micro Electro Mechanical Systems (2009), O. Vazquez Mena, G. Villanueva, V. Savu, K. Sidler, M.A.F. van den Boogaart and J. Brugger, “Metallic Nanowires by Full Wafer Stencil Lithography ”, Nano Letters, 8 (2008), 3675-3682 S. Krishnamoorthy, M.A.F. Van den Boogaart, J. Brugger, C. Hibert, R. Pugin, C. Hinderling and H. Heinzelmann, “Combining micelle self-assembly with nanostencil lithography to create periodic/aperiodic micro-/nanopatterns on surfaces ”, Advanced Materials, 20 (2008), 3533-3538 T. Kiefer, F. Favier, O. Vazquez, G. Villanueva and J. Brugger , “A single nanotrench in a palladium microwire for hydrogen detection ”, Nanotechnology, 19 (2008), 125502 K. Lee, M. Duchamp, G. Kulik, A. Magrez, J.W. Seo, S. Jeney, A.J. Kulik, L. Forro, R.S. Sundaram and J. Brugger , “Uniformly Dispersed Deposition of Colloidal Nanoparticles and Nanowires by Boiling”, Applied Physics Letters, 91 (2007), 173112 K.W. Eberhardt, S. Mouaziz, G. Boero, J. Brugger and B.H. Meier, “Direct observation of nuclear spin diffusion in real space”, Physics Review Letters, 99 (2007), 227603 (4 pages) C. Ingrosso, V. Fakhfouri, M. Striccoli, A. Agostiano, A. Voigt, G. Gruetzner, M.L. Curri and J. Brugger, “An Epoxy Photoresist Modified by Luminescent Nanocrystals for the Fabrication of 3D High-Aspect-Ratio Microstructures”, Advanced Functional Materials, 17 (2007), 2009-2017 2007-2009 Patents J. Brugger, C. Martin-Olmos, G. Mermoud, A. Martinoli, “Containers assembled in fluid and corresponding production ”: US 61/170,673 J. Brugger, K. Pataky, Th. Halazonetis, “An X-ray microcolimator for irradiating regions, whose width is in the micrometer to submicrometer range ”: US 61/046,007 Brugger Juergen van den Boogaart Marc Arcamone Julien Sansa Marc Pérez Murano Francesco, “Method and apparatus for plane positions of disk substrates”: ES P200802208 J Brugger, F. Vakhfouri, G. Gruetzner, K. Pfeiffer, “Micro optical articles, process of their production and uses”: EP 08075732.1 and US 61/091,882

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Research Interests Our laboratory is devoted to micro/nanosystems (MEMS/NEMS) and to the development of new fabrication techniques for highly miniaturized functional devices and systems. We focus in particular on rapid prototyping techniques to create innovative micro and nanostructures by novel patterning methods (e.g. nano-stenciling and inkjet printing). We share our generic technologies with partners from fundamental material science, applied physics and life-sciences enabling to continously push the limits of experimental investigations. We also include the study of scalability for future cost-effective and eco-friendly micro/nanomanufacturing to enable technology transfer and commercialization of new nanotechnology-based products.

2007-2009 External Grants received at the EPFL SystemsX IPP “inkjet cell mimetics” 2008-2009

Current Group 4 Postdoctoral Fellows 6 PhD Students 1 PhD Student (external) 1 Visiting Student 0.5 Administrative Assistant

CHF 93’850

FN Radio on Paper total: 218’056; LMIS-1: 109’028 2006-2008

CHF 109’028

FN Radio on Flexible total: 257’800; LMIS-1: 128’900 2008-2010

CHF 128’900

FN Nanotera “SELFSYS” total: 1’841’098; LMIS1: 425’000 2009-2013 CHF 425’000 Collaborations & Networks CH-based: IBM Zurich, CSEM, ETHZ, UniBE, F. Miescher Institute, RFID Center, MiCS, EMPA FN IC Nano total: 205’504.-; LMIS-1: 57’100 2006-2007

FN Cells 2 total: 714’290; LMIS-1: 178’290 2009-2012 FN Cells 1 total: 660’688; LMIS-1: 165’172 2006-2009 FN Ambitione 2008-2011 FN 3D SiNW total: 389’550; LMIS-1: 195’000 2009-2012 CTI “Ceramicro” 2008-2010 CE 7FP STREP “Novopoly” 2005-2008

CHF 57’100

International: Stanford University, University of Twente, Technical University of Denmark, CNM Barcelona, CNR Bari Italy, CNRS CHF 178’290 Montpellier France, Cambridge University Framework collaborations: Nanotera ’SELFSYS’ (PI) with ETHZ, CSEM, CHF 165’172 IBM, ICARE; EU NanoICT working group NEMS (working group leader); EU Marie-Curie ’ACAPOLY’ (PI), with Microresist Technology CHF 450’185 Berlin; EU IP HYSYS on new Hydrogen systems for automotives; EU IP NaPa on Emerging nanopatterning methods (managing board member) (ended 2008) CHF 195’000 CHF 275’000 Teaching Activities Nanotechnology for Engineers (master course), Technology of CHF 863’040 microstructures (3rd year), Clean room TP (hands-on MEMS and nanotechnology, Doctoral school course on Nanoengineering

CE 7FP Marie-Curie “Acapoly” 2008-2012

CHF 597’238

CE 7FP IP “Hysys” 2006-2009

CHF 387’600

CE 7FP CA “nanoICT” 2008-2010

CHF 91’592

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Robotic Systems Laboratory 2 Reymond Clavel, Full Professor Reymond CLAVEL, obtained his degree in mechanical engineering at the EPFL in 1973. After nine years of experience in industrial plants (R&D), he was appointed professor at the EPFL, where he obtained his PhD degree in parallel robotics in 1991. He was then consecutively entrusted with the following positions: Head of the department, Director of the Section of micro engineering and, in 1993, Director of the Laboratory of robotics systems. R. Clavel’s research successes in parallel, industrial and medical robotics received worldwide special mentions among which the JIRA Award for the DELTA concept (Japan Industrial Robot Association), 1989, the Golden Robot Award, 1999, for the Delta concept and for the perseverance to support the success of new robot applications in industries. R. Clavel is at the origin of 26 patents. His research results are continuously transferred to the industry. During his academic career, he has led successfully 25 students to their PhD. He is currently supervising six new PhD students. Keywords: Parallel robots. http://lsro.epfl.ch/

2007-2009 Significant Publications V. Nabat, R. Clavel, “Le pick-and-place et la robotique parallèle”, JAUTOMATISE, Histoire de la robotique (Nov. 08), Y. Stauffer, Y. Allemand, M. Bouri, J. Fournier, R. Clavel, P. Métrailler, R. Brodard, F. Reynard, “The WalkTrainer-A New Generation of Walking Reeducation Device Combining Orthoses and Muscle Stimulation”, IEEE Transactions on Neural Systems and Rehabilitation Engineering (Feb. 09), Vol. 17, NO. 1 P. Métrailler, R. Brodard, Y. Stauffer, R. Frischknecht, R. Clavel, “Cyberthosis: Rehabilitation Robotics With Controlled Electrical Muscle Stimulation”, Ch. 17, Book Rehabilitation Robotics (Aug. 07), ISBN 978-3902613-04-2, I-Tech Education and Publishing R. Clavel, P. Pham, B. Lorent, B. Le Gall, M. Bouri, “New Variants of Delta Robots and Double-Tilt Platform for Assembly”, Invited paper, Proceedings of Robotic Systems for Assembly, 3rt International Colloquium of the Collaborative Research Center, Braunschweig (28/29.04.08), D. Zhang, W. Driesen, J-M. Breguet, R. Clavel, J. Michler, “A highsensitivity and quasi-linear capacitive sensor for nanomechanical testing applications”, Journal of Micromechanics and Microengineering (2009), 19, IOP Publishing C. Canales, F. Cosandier, G. Boetsch, V. Chatagny, J.H Lee, G. Bringout, R. Clavel, “A complete manipulation platform for characterization of micro-components”, International Symposium on Optomechatronic Technologies (ISOT), San Diego (2008), B. Dagon, C. Baur, V. Bettschart, “Intraoperative update of liver surgery planning based on ultrasound images”, SURGETICA (2007), p. 419-423 Sauramps Medical E. Lubrano, R. Clavel, “Thermal Behavior of an Ultra High-Precision Linear Axis Operating in Industrial Environment”, Proc. of 9th International Workshop on Research and Education in Mechatronics, Bergamo, Italy (18/19.09.08),

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Research Interests The LSRO2 is a multidisiplinary research unit working mostly in the fields of robotics, micro-robotics and high precision instrumentation. Its main domains of expertise are: Parallel Kinematics / Conception of mechanisms for parallel robots with high precision (nanometric resolution), high stiftness and high dynamics (frictionless bearing, flexures, grippers, tools changer force sensor) / Micro-factory laboratory / Virtual reality and active interfaces / Medical robots and devices (rehabilitation of paraplegia, sport training / Surgical robots

2007-2009 Patents Ch. BAUR jr, R. CLAVEL, P. HELMER, M. WEIBEL / 08.05.2008, “Parallel Kinematic structure”: WO2008052581 (A1) CARTIER-MILLON Christophe, CLAVEL Reymond, VIGOUROUX Didier / 04.08.2008, “Dispositif de télécommande pour interrupteur équipé d’un mécanisme amplificateur et d’un générateur rotatif, et interrrupteur doté d’un tel dispositif.”: no de dépot: 0804433 T. AKIYAMA, R. CLAVEL, M. DAFFLON, U. STAUFER / 18.07.2007, “Probe module, probe array and a method of assembling probe arrays.”: 07405154.1-1234 2007-2009 External Grants received at the EPFL Trilame 07/09

Current Group 5 PhD Students 6 Laboratory Assistants 3 Engineers 1 Visiting Student 1 Group Leader 1 Senior Technician 2 Scientific Advisers 1 Scientist 2 Administrative Assistants 1 Trainee

Collaborations & Networks Industries: GF Agie Charmilles, Willemin-Macodel, Step Tec, Mikron, Baur, Asyril, Bosch Packaging Technology, Force Dimension, Mecartex, Octax Microscience,, OFFIS e.V., STMicroelectronics, Dr. Volker Klocke Nanotechnik, Tescan, Nanoscale Technologies. Universities / hospitals / Laboratories: CHUV - HUG - LIRMM (Dr. F. Pierrot) Uni. Montpellier - Institut of Machines Tools and Production Technology, TU, Braunschweig - IRR (institut de recherche en réadaptation-réinsertion), Sion, Technische Universiteit Eindhoven, Universität Stuttgart, Ceské vysoké uceni technické v Praze, Université Pierre et Marie Curie, University of Edinburgh, Danmarks Tekniske Universitet, Uni. Bâle, Uni. Berne, Uni. Genève, Uni. Zürich, ETHZ, ZHW, HTI - Bienne, Klinik St-Anna Lucerne, Hop.Cant. Lucerne, CSEM, EMPA, METAS.

CHF 552’920

Nanohand EU 06/09

Teaching Activities CHF 773’560 Design of mechanisms: SEL, BA1, 3h/week

Golem EU 06/09

CHF 566’388 Mechanical design project: SEL, BA2, 3h/week

FNS - Etalonnage 07/10

CHF 136’488 Microengineering components I & II : SMT, BA3 4, 3h/week (5 credits)

CTI - Mikra II 06/09

CTI - Antichoc I 2007

CHF 300’000 Robotics-microrobotics I & II: SMT SGM, MS 1 2, I: 3h/week - II: 2h/ week CHF 100’000 Project of semester and Master (TPM): 12 - 20/year CHF 70’000

COME 06/07

CHF 250’500

COME 07/08

CHF 210’000

COME 08/09

CHF 245’100

CTI - Antichoc II 09/10

Brevet Delta 07/08/09

CHF 187’281.50

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The Sensors, Actuators and Microsystems Laboratory Nico de Rooij, Full Professor Director of the Institute of Microengineering Vice-President of CSEM Nico de Rooij received a M.Sc. degree in physical chemistry from the State University of Utrecht, The Netherlands, in 1975, and a Ph.D. degree from the Twente University of Technology, The Netherlands, in 1978. From 1978 to 1982, he worked at the Research and Development Department of Cordis Europa N.V., The Netherlands. In 1982, he joined the Institute of Microtechnology of the University of Neuchâtel, Switzerland (IMT Uni-NE), as professor and head of the Sensors, Actuators and Microsystems Laboratory. Since October 1990 till October 1996 and again from October 2002 until June 2008, he has been the director of the IMT UNI-NE. He lectured at the Swiss Federal Institute of Technology, Zurich ETHZ, and since 1989, he has been a part-time professor at the EPFL. He has been appointed Vice-President of the CSEM SA in February 2008 and heads the newly created Microsystems Technology Division of CSEM SA, which started its activities in April 2008. Since January 2009, he has also been appointed Director of EPFL’s Institute of Microengineering, following the transfer of the IMT Uni-NE to the EPFL. Keywords: Microsystems, MEMS. http://samlab.epfl.ch

2007-2009 Significant Publications P.L.T.M. Frederix, P.D. Bosshart, T. Akiyama, M. Chami, M.R. Gullo, J.J. Blackstock, K. Dooleweerdt, N.F. de Rooij, U, Staufer, A. Engel, “Conductive supports for combined AFM-SECM on biological membranes”, Nanotechnology (September 24, 2008), D. Bayat, T. Akiyama, N.F. de Rooij, U. Staufer, “Dynamic behavior of the tuning fork AFM probe ”, Microelectronic Engineering (May 2008), 1018-1021 D. Teyssieux, D. Briand, J. Charnay, N.F. de Rooij, B. Cretin, “Dynamic and static thermal study of micromachined heaters: the advantages of visible and near-infrared thermography compared to classical methods ”, Journal of Micromechanics and Microengineering (June 2008), A. Han, M. Creus, G. Schurman, V. Linder, T. R. Ward, N.F. de Rooij, U. Staufer, “ Label-free detection of single protein molecules and protein-protein interactions using synthetic nanopores ”, Analytical Chemistry (June 15, 2008), 4651-4658 W.E. Morf, P.D. van der Wal, N.F. de Rooij, “Computer simulation and theory of the diffusionand flow-induced concentration dispersion in microfluidic devices and HPLC systems based on rectangular microchannels ”, Analytica Chimica Acta (August 1, 2008), 175-181 A. Homsy, V. Linder, F. Lucklum, N.F. de Rooij, “Magnetohydrodynamic pumping in nuclear magnetic resonance environments”, Sensors and Actuators B-Chemical (April 10, 2007), 636-646 S. Generelli, R. Jacquemart, N.F. de Rooij, M. Jolicoeur, M. Koudelka-Hep, O.T Guenat, “Potentiometric platform for the quantification of cellular potassium efflux ”, Lab on a Chip (2008), 1210-1215 D. Briand, O. Manzardo, N.F. de Rooij, J. Hildenbrand, J. Wollenstein, , “Gas detection using a micromachined FTIR spectrometer ”, IEEE Sensors (2007), 1364-1367 2007-2009 Awards IEEE Jun-Ichi Nishizawa Gold Medal, IEEEE 2007-06-16 Award for pioneering contributions to microsystem technology and effective transfer into industrial products and applications

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Current Group Research Interests The research activities include the design, micro fabrication and application of miniaturized silicon based 5 Group Leaders 2 Scientists sensors, actuators, and microsystems. The following research areas are currently covered: 15 PhD Students (external) Time-Frequency: Development of technologies for the realization of components and systems for time- 5 Master Students frequnecy applications. Micro Bio Electrochemical Systems: Development of variety of microsystrems, based on electrochemical detection, for environmental monitoring, process control and biomedical applications. Optical MEMS: Development of microsystems for applications in optcal fiber based communication networks, advanced instrumentation and displays. Microfluidics: Development of microsystems for biomedical applications, incorporating sample pretreatment, separation and fluid handling. Tools for nanoscience: Development of SPM (Scanning Probe Microscopy) Tools for the observation and manipulation at the nanometer scale.

2007-2009 External Grants received at the EPFL Nano-Tera.CH 2009-2011

CHF 980’000

Industry 2007-2009

CHF 300’000

FNS 2009-2012

CHF 450’000

EU 2006-2009

CHF 600’000

ESA 2008-20111

CHF 200’000

CTI 2007-2010

CHF 600’000

Collaborations & Networks The Sensors, Actuators and Microsystems Laboratory (SAMLAB) is currently involved in the following collaborations: On national level: cooperations with the ETHZ (NanoTera.ch), University of Neuchâtel (FN Sinergia), University of Geneva (NCCR MANEP, NCCR Quantum Photonics),University of Basle (NCCR Nanoscale Science), CSEM SA as well several Swiss industries (CTI, direct contracts) On international level: cooperations with partners from the EU (FP6 projects), Singapore. Teaching Activities Master course: Integrated Sensors and Actuators, Semester Projects, PhD projects.

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Microvision & Microdiagnostics Christian Depeursinge, Adjunct Professor CDI research platform (Chair) Christian Depeursinge is the leader of the Microvision and Micro-Diagnosis (MVD) group at the Advanced Photonics Laboratory of the Institute of Microengineering at EPFL (Ecole Polytechnique Fédérale de Lausanne), Switzerland (http://apl.epfl.ch/muvision). His research and expertise are in biomedical engineering and optics. His current research topics include coherent and incoherent Imaging applied to diagnostics in biology, His research group pioneered in the development of DHM technology. He is author and co-author of over 100 papers published in peer reviewed journals, several book chapters and more than 30 patents. He has given more than 25 invited lectures and plenaries in the last five years. He developed many projects in cooperation with national and international industries. He is co-founder of a start-up company (Lyncée Tec SA: www.Lynceetec.com). He is chairing the “neuro-imaging” platform developed by STI in collaboration with the Brain and Mind Institute of the SV faculty BMI. He is currently teaching at EPFL and occasionally in foreign universities and institutes. Keywords: optics,microscopy, holography,coherent imaging,tissue optics. http://apl.epfl.ch/muvision

2007-2009 Significant Publications Depeursinge, C. et Al., "DHM: Digital Holographic Microscopy, a novel modality in microscopy", Nature Photonics (2009), submitted E. Shaffer et al., "Digital holographic microscopy investigation of second harmonic generated at a glass/air interface", Optics Letters (2009), 2450 B. Rappaz et al., "Spatial analysis of erythrocyte membrane fluctuations by digital holographic microscopy", Blood Cells, Molecules, and Diseases 42 (2009), 228 J. Kühn et al., "Sub-micrometer tomography of cells by multiplewavelength DHM in reflection", Optics Letters 34 (2009), 653 B Rappaz et al., "Non-invasive characterization of the fission yeast cell cycle by monitoring dry mass with DHM", JBO Letters 14 (2009), 034049 J. Kühn et al., "Axial sub-nanometer accuracy in digital holographic microscopy", Measurement Science and Technology 19 (2008), 074007 B. Rappaz et al., "Simultaneous cell morphometry and refractive index measurement with dual-wavelength...", Optics Letters 33 (2008), 744 B. Rappaz et al., "Comparative study of human erythrocytes by digital holographic microscopy,...", Cytometry A 73A (2008), 895 F. Charrière et al., "Amplitude point spread function measurement of high NA microscope objectives by digital holographic microscopy", Optics Letters 32 (2007), 2456 F. Charrière et al., "Influence of shot noise on phase measurement accuracy in digital holographic microscopy", Opt. Express 15 (2007), 8818

2007-2009 Awards LEICA Geosystems Prize , SSOM 2007-09-12

Young Researcher Award , ISGP/ ESA /ASGSB /ELGRA 2008-06-22 Life on earth symposium Omega Student Prize, EPFL 2008-10-04

J. Kühnet al., "Real-time dual-wavelength digital holographic microscopy with a single hologram acquisition", Opt. Express 15 (2007), 7231 A. Marian et al., "On the complex three-dimensional amplitude point spread function ...", J. Microsc. 225 (2007), 156

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DHM of cells in microgravity

Research Interests In MVD group, the main focus has been Optics plays an increasing role in nanotechnologies, life sciences, biophysical research and biomedical engineering. Optical imaging, in particular, enjoys a growth of interest, based on the development of new concepts in coherent imaging. Exploitation of light coherence appears as a cornerstone in the development of new imaging technology in microscopy will provide access to the intimate organization of biological matter, at the ultimate limit of single molecules. The development, in MVD group (Microvision and Microdiagnostics group) of Digital Holographic Microscopy (DHM) appears as a promising imaging approach, because it provides the full complex photonic wavefield which is interpreted in terms of full complex dielectric tensor of matter. This novel method of microscopy is suitable for materials investigations at the nanoscale, such as nanoparticles, surface and more generally complex materials: layered materials, photonic crystals, plasmonics or random media. The exploitation of the properties of coherent optics opens the way to nano metrology and imaging: micro-optics, MEMS and MOEMS. Spectroscopy also provides a multi-modality imaging combining DHM andfluorescence. Nonlinear optical properties of matter (SHG,THG, CARS) provides an access to the molecular structure and biochemical composition of living cells and tissues. Pioneering work on Digital Holography applied to Life Sciences have been realized thanks to an interdisciplinary approach with biologists. Tissue diagnosis: functional imaging biological cells and tissues has been developed by the recourse to novel coherent and incoherent imaging methods: photon and photon density waves. Finally, targeting biological tissues and cells with engineered beams provide means to manipulate or treat cells and tissues.

2007-2009 Patents DEPEURSINGE C. et al., "Method and Apparatus to Measure and Compute the Amplitude Point Spread Function...": WO 2007116365 COLOMB T. et al., "Wave Front Sensing Method and Apparatus...": US2008265130 DEPEURSINGE C. et al., "Sensor system and sampling cell assembly ...": US2008231857 2007-2009 External Grants received at the EPFL STI seed money 2007-2009 Space Center EPFL 2007-2008 NCCBI 2009-2011 FNSNF 2008-2010 FNSNF 2006-2008 FNSNF 2006-2008

Current Group 4 Scientists 6 PhD Students (external) 2 Engineers

Collaborations & Networks Swiss collaborations and networks: Prof P.Magistretti: Laboratory of Neuroenergetics and Cellular Dynamics LNDC,SV,EPFL Dr.P.Marquet, Center for Psychiatric Neuroscience, DP-CHUV/UNIL Prilly Prof Unser, BIG, LIB, IOA – EPFL Prof.Meda, Dpt. de physiol.cell. et métab. CMU Genève Dr.Marcel Egli Space Biology Center ETHZ Prof. Y.Barral, Institut f. Biochemie HPM D 8.3 ETHZ Zürich

Research institutions: CHF 110'000 CSEM: Swiss Center for Electronics and Microtechnology Startups and industries: CHF 22'532 Dr Yves Emery, PhD, Lyncée Tec SA www.lynceetec.com PSE A Lausanne CHF 130'000 Dr.K.Hassler SCANCO Medical AG www.scanco.ch Fabrikweg 2 Brüttisellen CHF 292'100 International Network: Oulu University Finland , Bremer Institut Fuer Angewandte Strahltechnik Gmbh,Bilkent University, Turkey, CNR CHF 143'055 Istituto Nazionale di Ottica Applicata Italia, National University Of Ireland,Warsaw University Of Technology,Poland,Münster univ.GMBH. CHF 250'772

CTI LS 2006-2008

CHF 822'703 Teaching Activities Regular courses: CHF 803'736 - Postgraduate Course (2001-now) on Coherent Imaging (Doctoral School) CHF 147'000 - Course on bio-optical instrumentation (winter semester: 28 periods: microengineering and life science sections) CHF 923'869 Thesis supervision: five PhD students are achieving their PhD degree in CHF 428'693 the MVD group. Laboratory training and Master.

CCMX AN 2008-2011

CHF 258'229

ESRP Space Center EPFL 2007 -2010

CHF 150'000

EU STREP 2008-2011 EU IP 2006-2010 CTI MT 2008-2010 CTI LS 2008-2010

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Electronics and Signal Processing Laboratory Pierre-André Farine, Full Professor Associate Professor UniNE Pierre-Andre Farine is full professor in electronics and signal processing at the Ecole Polytechnique Fédérale de Lausanne (EPFL STI) and associate professor at the University of Neuchâtel. He is head of the Electronics and Signal Processing Laboratory (ESPLAB) and of the Pattern Recognition Laboratory (PARLAB) at the institute of Microtechnology (IMT NE) of the EPFL. He is currently working in projects for CMOS implementation of video and audio compression algorithms in telecommunications and for the use of UWB and GNSS systems for local, global positioning and navigation, and for time acquisition and network synchronization. He has 12 years experience in GPS receivers design in low power integrated circuits. At EPFL since 01.01.2009 Keywords: GPS, Galileo, GNSS, UWB, mmRFIC, APS, CMOS, Low Power, IC, CELP, H264. http://esplab.epfl.ch/

2007-2009 Significant Publications P. Saad, R. Merz, F. Chastellain, C. Robert, U. Yodprasit, C. Botteron, P.-A. Farine, R. Caillet, A. Heubi, N. Senouci, “A Low-Power, Low Data-Rate, Ultra-Wideband Receiver Architecture for Indoor Wireless Systems”, Proc. of the 2008 IEEE International Conference on Ultra-Wideband (September 2008), C. Botteron, G. Waelchli, G. Zamuner, M. Frei, D. Manetti, F. Chastellain, P.-A. Farine, “A flexible Galileo E1 Receiver Platform for the Validation of Low Power and Rapid Acquisition Schemes”, Proc. of 19th ION GNSS (September 2007), 2383-2395 R. Merz, C. Botteron, P.-A. Farine, “Performance of an Impulse Radio Communication System in the Presence of Gaussian Jitter”, Proc. of ICUWB 2007 (September 2007), U. Yodprasit, P. Saad, C. Botteron, P.-A. Farine, “Bulk-source-coupled CMOS Quadrature Oscillators”, IEE Electronics Letters (January 2009), Vol. 45 S. Grassi, P. Heck, P. Stadelmann, P. Cotofrei, P. Dinissen, F. Meylan, J.-P. Mignot, J.-N. Pfeuti, F. Piccini, P. Geiser, G. Biundo, P.-A. Farine, J. Grupp, K. Stoffel, “Watch-dictaphone for Automatic Medical Codification”, Proc. EUSIPCO 2008 (August 2008), K. Imfeld, S. Neukom, A. Maccione, Y. Bornat, S. Martinoia, P.-A. Farine, M. Koudelka, L. Berdondini, “Large-Scale, High-Resolution Data Acquisition System for Extracellulat Recording of Electrophysiological Activity”, IEEE Transactions on Biomedical Engineering (August 2008), Vol. 55, N° 8 P. Dubois, C. Botteron, V. Mitev, C. Menon, P.-A. Farine, P. Dainesi, A. Ionescu, H. Shea, “Ad-hoc Wireless Sensor Networks for Exploration of Solar-system Bodies”, Acta Astronautica, Elsevier (April 2009), Vol. 64, N°5-6 R. Merz, F. Chastellain, A. Blatter, C. Botteron, P.-A. Farine , “An Experimental Platform for an Indoor Location and Tracking System”, Proc. of ENC-GNSS 2008 (April 2008), 2007-2009 Patents R. Merz, C. Botteron, P.-A. Farine, “Procédé d’identification d’une donnée codée par modulation PPM, récepteur pour ce procédé.”: PCT/EP2009/053471

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Research Interests GNSS receivers, ultra precise miniature atomic clocks for synchronization systems for mobile telephones such as UMTS and Multi-Mode Sensor Arrays MMSA, UWB communication systems with carrier-less impulse radios for local positioning and ultra low power wireless data transmission. He is also working in active picture sensors APS, in multi-mode sensor arrays MMSA, in video and audio coding, compression and signal processing. Implementation of signal processing algorithms made in CMOS low power integrated circuits.

2007-2009 External Grants received at the EPFL ublox SA 2007-2009 SNF 205321-113976/1 2006-2010 SNF 200021-120187/1 2008-2010 SNF 200020-113472/1 2006-2009 PX Group 2008-2010 FP7 ICT 224132 2008-2011 FP7 GSA 228339 2009-2011

Current Group 2 Postdoctoral Fellows 1 Research Assistant 15 PhD Students 1 Adjunct Professor 3 Senior Scientists 3 Scientists 2 Group Leaders 1 Technician 1 Engineer 2 Administrative Assistants

Collaborations & Networks CHF 537’600 Within LEA (European Associated Laboratory) in microtechnology, EPFL is associated with the french CNRS and the University of FrancheCHF 384’881 Comté in Besançon. LEA is characterized with activities for teaching (Summer courses HiM Highlights in Technology, and Ateliers d’Arc-etCHF 156’798 Senans) for PhD students. CHF 215’286 For research and technology transfer, collaborations with the swiss and european industry in microengineering and in microtechnology, such as CHF 300’000 Swatch Group (EM-Marin, The Swatch Group R&D units, ETA, OSA), PX Group, ON Semiconductors, Semtech, ublox, Johnson & Johnson CHF 1’394’600 NE, Syderal, Spectratime, Colibrys, etc. CHF 135’000

CTI 9861 2009-2010

Teaching Activities CHF 135’300 At UniNE, ESPLAB and PARLAB are involved in teaching activities for BSc in micro and nanosciences UniNE: CHF 145’700 - Signal processing and systems I & II (6 ECTS) - Control systems (3 ECTS) CHF 336’450 - Image processing (3 ECTS) - Pattern Recognition (3 ECTS) CHF 432’000 for MSc in micro and nanotechnology UniNE: CHF 70’000 - Wireless Communications and RF Design (3 ECTS)

CTI 9124 2007-2009

CHF 870’000

CTI 8871 2007-2009

CHF 510’000

CTI 8811 2000-2011

CHF 620’000

CTI 8711 2007-2009

CHF 590’000

CTI 8427 2007-2009

CHF 700’000

armasuisse 8003405652 2008-2010

CHF 400’000

FP7 GSA 228237 2009-2011 FP7 GSA 228193 2009-2011 FP6 MOIF 21926 2006-2009 ESA mUSO 2007-2009

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Laboratory of Intelligent Systems Dario Floreano, Associate Professor Responsible of Printed Circuit Workshop (ACI), Responsible of Master Specialization in Robotics & Autonomous Systems Dario Floreano received an M.A. in Cognitive Science from University of Trieste (Italy) in 1988, an M.S. in Neural Computation from the University of Stirling (UK) in 1991, and a PhD in Evolutionary Robotics in 1995 from University of Trieste (Italy), all of them with distinction. In 1996 he was appointed senior researcher at the Department of Computer Science of EPFL where he established the Robot Learning group. In 1998 he was invited researcher at Sony Computer Science Labs in Tokyo where he worked on the Sony robotic division. In 2000 he was awarded a Swiss National Science Foundation professorship for carrying out research in bio-inspired robotics at EPFL. In 2005 he was appointed associate professor by EPFL and established the Laboratory of Intelligent Systems. Prof. Floreano is co-founder of the International Society for Artificial Life, Inc., member of the Advisory Group to the European Commission for Future Emerging Technologies, and past-member of the Board of Governors of the International Society for Neural Networks. Keywords: Bio-inspired Robotics; Bio-inspired A.I.; Systems Biology; Evolutionary Computation; Neural Computation; Swarm Intelligence. http://lis.epfl.ch/

2007-2009 Significant Publications Karlen, W., Mattiussi, C. and Floreano, D., “Sleep and Wake Classification With ECG and Respiratory Effort Signals.”, IEEE Transactions on Biomedical Circuits and Systems (2009), In press Waibel, M., Keller, L. and Floreano, D., “Genetic Team Composition and Level of Selection in the Evolution of Multi-Agent Systems”, IEEE Transactions on Evolutionary Computation (2009), In press Hauert, S., Zufferey, J.-C. and Floreano, D., “Evolved swarming without positioning information: an application in aerial communication relay.”, Autonomous Robots (2009), In press Marbach, D., Mattiussi, C. and Floreano, D. , “Replaying the Evolutionary Tape: Biomimetic Reverse Engineering of Gene Networks.”, Annals of the New York Academy of Sciences (2009), 1158: 234–245 Marbach, D., Schaffter, T., Mattiussi, C. and Floreano, D., “Generating Realistic in silico Gene Networks for Performance Assessment of Reverse Engineering Methods.", Journal of Computational Biology (2009), 16(2): 229-39 Hauert, S., Winkler, L., Zufferey, J.-C. and Floreano, D., “Ant-based Swarming with Positionless Micro Air Vehicles for Communication Relay.", Swarm Intelligence (2008), 2(2-4), 167-188 Mattiussi, C. and Floreano, D., “Analog Genetic Encoding for the Evolution of Circuits and Networks.”, IEEE Transactions on Evolutionary Computation (2007), 11(5): 596-607 Floreano, D., Mitri, S., Magnenat, S. and Keller, L., “Evolutionary Conditions for the Emergence of Communication in Robots.”, Current Biology (2007), 17: 514-519 2007-2009 Awards Best paper, International Conference on Intelligent Robots and Systems (IROS) 2007-10-30 Best paper award for vision-based indoor flying robot Winner, DREAM Organizers, New York 2007-12-20 Winner of the first International Competition on Reverse Engineering of Gene Regulatory Networks, 5-gene network category Best project, European Commission, Future & Emerging Technologies 2008-01-07 European project Swarmbot, whose robots have been developed at the Laboratory of Intelligent Systems, is nominated Success Story. Best science video, American Association for Artificial Intelligence 2008-07-15 Best video award for educational video showing development of bio-mimetic robots

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Research Interests Principles of biological self-organization, such as evolution, learning, and adaptation; bio-inspired robots capable of autonomous behavior, such as terrestrial, flying, jumping, evolutionary, and networked robots; computational biology.

Current Group 13 PhD Students 3 Postdoctoral Fellows 2 Engineers 8 Master Students 1 Visiting Student 1 Administrative Assistant

2007-2009 Patents Zufferey, J-C., Beyeler, A., Floreano, D., “Visual autopilot for nearobstacle flight”: PCT/EP/US filed on April 15, 2008 2007-2009 External Grants received at the EPFL Swiss NSF 2008-2012

CHF 240’000

Swiss NSF 2008-2010

CHF 549’000

Swiss NSF 2007-2010

CHF 343’000

European Commission 2009-2013

CHF 1’150’000

Collaborations & Networks Prof. R. Wood, Harvard University Prof. R. Full, Berkeley Center for Biomechanics Prof. M. Sitti, Carnegie Mellon University Dr. A. Stoica, NASA JPL Robotics Division Prof. H. Lipson, Cornell University Prof. M. V. Srinivasan, University of Queensland Prof. C. Ellington, University of Cambridge Prof. E. Szathmary, Eotvos University and Collegium Budapest Dr. J. Duparré, Fraunhofer Institute for Microoptics, Jena Prof. H. Buelthoff, Max-Planck Institute for Biological Cybernetics Tuebingen Prof. M. Dorigo, Université Libre de Bruxelles Prof. R. Siegwart, ETHZ Prof. R. Pfeifer, University of Zurich Prof. L. Keller, University of Lausanne Teaching Activities Doctoral course: Autonomous Robots, 4 credits Doctoral course: Advanced Robotics Seminar, 2 credits Master course: Biological and Artificial Intelligent Systems, 3 credits Master course: Mobile Robots, 3 credits Master course: Robotics Laboratory Work, 2 credits Master course: EPFL Robot Competition, 2 credits

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Microsystems Laboratory 2 Martinus Gijs, Full Professor Martin A.M. Gijs received his degree in physics in 1981 from the Katholieke Universiteit Leuven, Belgium, and his PhD degree in physics at the same university in 1986. He joined the Philips Research Laboratories in Eindhoven, The Netherlands, in 1987 and the Ecole Polytechnique Fédérale de Lausanne (EPFL) in 1997. He presently is a professor in the Institute of Micro-engineering, where he is responsible for the Microsystems Technology Group. He is in the editorial board of Microfluidics and Nanofluidics and the Journal of Micromechanics and Microengineering. He has published over 160 papers in peer-reviewed journals and holds over 20 patents. Keywords: microfluidics, bioMEMS, technology development, microsystems. http://lmis2.epfl.ch/

2007-2009 Significant Publications Martin A. M. Gijs, Frédéric Lacharme, and Ulrike Lehmann, “Microfluidic applications of magnetic particles for biological analysis and catalysis (review)”, Chemical Reviews (2009), D. Berdat, A.C. Martin Rodriguez, F. Herrera, and M.A.M. Gijs, “Label-free detection of DNA with interdigitated micro-electrodes in a fluidic cell”, Lab on a Chip 8 (2008), 302-308 Virendra K. Parashar, Jean-Baptiste Orhan, Abdeljalil Sayah, and Martin A.M. Gijs, “Borosilicate nanoparticles prepared by exothermic phase separation (+ journal COVER page)”, Nature Nanotechnology 3 (2008), 589-594 J.-B. Orhan, J. Flueckiger, V. K. Parashar, and M. A. M. Gijs, “In-situ modification of poly(dimethylsiloxane) microchannels with a sol-gel borosilicate glass coating ”, Langmuir 24 (2008), 9154-9161 E. Dahan, V. Bize, T. Lehnert, J.-D. Horisberger, and M.A.M. Gijs, “Rapid fluidic exchange microsystem for recording of fast ion channel kinetics in Xenopus oocytes”, Lab on a Chip 8 (2008), 1809-1818 Donqing Li, Editor-in-Chief; Martin Gijs, Section Editor, “Encyclopedia of Microfluidics and Nanofluidics, Springer Science+Business Media”, LLC (2008), 2226 pages F. Lacharme, C. Vandevyver, and M.A.M. Gijs, “Full on-chip nanoliter immuno-assay by geometrical magnetic trapping of nanoparticle chains ”, Analytical Chemistry 80 (2008), 2905-2910 M.A.M. Gijs, “Will fluidic electronics take off?”, Nature Nanotechnology 2 (2007), 268-270 2007-2009 Awards Best Poster award 33rd International Conference on Micro- and Nano-Engineering MNE07, Copenhagen, Conference organisation 2007-09-26 Bead-based protein microarrays realized through electrostatic self-assembly of carboxylated beads Best poster award Eurosensors XXII, Dresden, Conference organsiation 2008-09-10 Automated label-free optical sensor for multi-antibiotics detection in milk Prize ’DuPont des Matériaux 2009’, DuPont company 2009-04-30 Prize attributed for the Ph.D. thesis of Dr. Ulrike Lehmann: ’Manipulation of magnetic microparticles in liquid phases for on-chip biomedical analysis methods’

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Research Interests The laboratory has centered its activities on the following themes: development and use of novel microfabrication technologies, miniaturised magnetic applications, microfluidics and microsystems for biomedical applications (bio-MEMS).

2007-2009 Patents A. Rida, M. Gijs, O. Elsenhans, and G. Savatic, “Method and apparatus for transporting magnetic or magnetisable particles”: EP application 07006148.6 (2007) 2007-2009 External Grants received at the EPFL STREP European Commission no. 037118 2007-2010 Integrated Systems Centre (EPFL) Research project 2007-2008 Integrated Systems Centre (EPFL) Research project 2008-2009

Current Group 2 Postdoctoral Fellows 3 Senior Scientists 10 PhD Students 0.5 Administrative Assistant

Collaborations & Networks Intense national and international collaborations with academic and industrial partners in the biomedical, biological and chemical sciences. Teaching Activities Technologie des microstructures I (2 1 sem.h) M. Gijs, J. Brugger (85,15)

CHF 3’000’000 Travaux pratiques en salle blanche (1 sem.h.) in groups of 4 students accompanied by assistant A. Sayah, M. Gijs, J. Brugger (40,40,20) CHF 76’000 Technologie des microstructures II (3 sem.h) M. Gijs CHF 76’000

Integrated NanoTechnologies, LLC, Henrietta, New York 2008-2009 CHF 125’000 Indo Swiss Joint Research Programme (ISJRP) 2009-2012

CHF 150’000

FNS project 32003B-120422 2008-2011

CHF 140’000

FNS project 205320-111636 2006-2008

CHF 227’000

FNS project 200020-121558 2009-2012

CHF 194’000

FNS project 200020-119788 2008-20111

CHF 167’000

FNS project 200020-111679 2006-2008

CHF 102’000

CTI project 7920.3 NMPP-NM 2006-2008

CHF 135’000

CTI project 10004.1 PFNM-NM 2009-2010

CHF 143’000

CCMX project 2007-2009

CHF 410’000

Ambizione Research project PZ00P2 121827 2008-2011

CHF 451’000

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Basics of applied magnetism (1 sem.h) M. Gijs Doctoral course Glass microfabrication (1 sem h) M. Gijs, V.K. Parashar Doctoral course

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Optics and Photonics Technology Laboratory Hans Peter Herzig, Full Professor President of the European Optical Society Hans Peter Herzig received his diploma in physics from the Swiss Federal Institute of Technology in Zürich, CH, in 1978. From 1978 to 1982 he was a scientist with the Optics Development Department of Kern in Aarau, CH, working in lens design and testing. In 1983, he became a research assistant with the Applied Optics Group at the Institute of Microtechnology of the University of Neuchâtel, CH, working in the field of holographic optical elements. In 1987, he received his PhD degree in optics. From 1989 to 2001 he was head of the microoptics research group in Neuchâtel. 2001, he got a call as professor (C4) from the University of Stuttgart, Germany. From 2002 to 2008 he was full professor at the University of Neuchâtel. Professor Herzig joined the faculty at EPFL in January 2009. Dr. Herzig is in the editorial board of different scientific journals (JM3, Optical Review, JEOS). He served as Conference Chairman for international conferences of EOS, IEE, IEEE/LEOS, OSA and SPIE; and as Guest Editor of IEEE and OSA journals. He is editor of a well-known book on micro-optics (published in English and Chinese), author of 12 book chapters, over 100 “peer reviewed” articles and 220 conference proceedings. At EPFL since 01/01/2009 Keywords: Micro-optics, nanophotonics. http://opt.epfl.ch/

2007-2009 Significant Publications S. Herminjard, “Surface plasmon resonance sensor showing enhanced sensitivity for CO2 detection in the mid-infrared range”, Opt. Express (2009), Vol. 17, 293 B. Bai, “Asymmetrical coupling of surface plasmon polaritons on blazed gratings at normal incidence”, Phys. Rev. B (2009), Vol. 80, 035407 P. Ruffieux, “Micro-optical polarizer with high efficiency”, Opt. Express (2008), Vol. 16, 2023 E. Descrovi, “Near-field imaging of Bloch surface waves on silicon nitride one-dimensional photonic crystals”, Opt. Express (2008), Vol. 16, 5453 T. Sfez, “Near-field analysis of surface electromagnetic waves in the bandgap region of a polymeric grating written on a one-dimensional photonic crystal”, Appl. Phys. Lett. (2008), Vol. 93, 061108 C. Rockstuhl, “Liquid-Crystalline Thiol- and Disulfide-Based Dendrimers for the Functionalization of Gold Nanoparticles”, Journal of Microscopy-Oxford (2008), Vol. 229, 281 T. Akiyama, “Concept and demonstration of individual probe actuation in two-dimensional parallel atomic force microscope system”, Jpn. J. Appl. Phys. (2007), Vol. 46, 6458 C. Rockstuhl, “Design of an artificial three-dimensional composite metamaterial with magnetic resonances in the visible range of the electromagnetic spectrum”, Phys. Rev. Lett. PRL (2007), Vol. 99, 017401 2007-2009 Patents P. Torok, “Optical Disk and Reader therefor”: WO2006010882 O. Manzardo, “Miniature Lamellar Grating Interferometer Based on Silicon Technology”: US2008204879

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Current Group 1 Administrative Assistant 10 PhD Students 2 PhD Students (external) 1 Laboratory Assistant 1 Technician Building on a number of past and present research projects concerning optical and photonic nanostructures, 1 Senior Scientist the OPT Lab has developed a number of capabilities spanning the design, fabrication, and characterization of 1 Scientist nanostructured optical and photonic devices. Collectively, these capabilities permit the investigation of a wide 3 Postdoctoral Fellows range of nanoscale optical effects, which facilitates both an improved understanding of optical phenomena on the nanoscale as well as an accelerated approach to producing optical and photonic devices for practical applications. Research Interests The Optics & Photonics Technology Lab (OPT Lab) has longstanding activities in micro-optics. Microfabrication technologies like photolithography, resist processing, and reactive ion etching are used to manufacture refractive and diffractive micro-optical elements, birefringent optics (liquid crystal devices), as well as nano-scale optics (subwavelength structures, photonic crystals, near field microscopy).

2007-2009 External Grants received at the EPFL SNF 10/07-03/12

CHF 610’408

NanoTera 07/09-06/13

CHF 375’000

EU 06/08-08/11

CHF 602’000

EU 10/09-09/12

CHF 5’328’000 / 1’045 (for the lab)

ESA 06-09

CHF 135’000

CTI 10/07-03/10

CHF 419’000

Collaborations & Networks NEMO - Network of Excellence in Micro-Optics Prof. W. Nakagawa, Montana State University, Bozeman, USA Prof. Y. Fainmann, University of California, San Diego, USA Prof. M. Kuittinen, Prof. J. Turunen, University of Joensuu, Finland. Prof. P. Török, Imperial College London, UK. Teaching Activities - Lectures on “Introduction à l’optique”,University of Neuchâtel (until 2008). - Lectures on “Optique moderne”, University of Neuchâtel (until 2008). - Lectures on “Micro-optics and Optical MEMS”, Ecole Doctorale, EPFL (since 2007) - Lectures on micro-optics in national and international education courses (summer courses, tutorials, etc.)

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Nanostructuring Research Group Patrik Hoffmann, Senior Scientist CCE Member Of German nationality, Patrik Hoffmann was born in Landau in der Pfalz in Germany in 1961. After the studies in Chemistry at Fridericiana University (Ecole Polytechnique) of Karsruhe, he obtained his diploma of chemistry in 1988. He carried out his PhD in EPFL and got docteur ès sciences in 1992 for his work on the deposition of metallic micro- and nano-structures. In 1992, he moved to research center of IBM at Almaden in California, USA and then was employed by IBM. He moved back to EPFL in 1993 to join the Institute of Applied Optics as adjoint scientifique. In 1995 he became the head of dental section and department of R&D in a German galvanic company. In March 1997, he was nominated Maître d’enseignement et de recherche (MER), specialized in techniques of microfabrication by laser at the Institute of Applied Optics of department of microtechnics in EPFL. From April 2009 he heads the Advanced Materials Processing Laoratory of Empa, Swiss Federal Institute of Materials research and Testing at Thun. Keywords: Wettability, Mico-structuring, Electron-beam Deposition, Photodeposition, Photoablation, Nano-optics. http://apl.epfl.ch/

2007-2009 Significant Publications L. Wang, F. Montagne, P. Hoffmann, R. Pugin, “Gold nanoring arrays from responsive block copolymer templates”, Chemical Communications (2009), 3798-3800 I. Utke, P. Hoffmann, and J. Melngailis, “Gas-assisted focused electron beam and ion beam processing and fabrication”, Journal of Vacuum Science & Technology B (2008), 26, 1197-1276 M. G. Jenke, C. Santschi and P. Hoffmann, “Two-dimensional electrostatic force field measurements with simultaneous topography measurement on embedded interdigitated nanoelectrodes using a force distance curve based method”, Applied Physics Letters (2008), 92, 063113 X. Multone, Y. Luo, and P. Hoffmann, “Er-doped Al2O3 thin films deposited by high-vacuum chemical vapor deposition (HV-CVD)”, Materials Science and Engineering B-Solid State Materials for Advanced Technology (2008), 146, 35-40 Y. Poujet, J. Salvi, F. I. Baida, D. van Labeke, A. Perentes, C. Santschi, and P. Hoffmann, “Near-field optical images of subwavelength annular aperture arrays exhibiting an extraordinary transmission”, Journal of Microscopy-Oxford (2008), 229, 203-209 V. Friedli, C. Santschi, J. Michler, P. Hoffmann , and I. Utke, “Mass sensor for in situ monitoring of focused ion and electron beam induced processes”, Applied Physics Letters (2007), 90, 053106 L. Barbieri, E. Halary-Wagner, and P. Hoffmann, “Water Wetting Transition Parameters of Perfluorinated Substrates with Periodically Distributed Flat-Top Microscale Obstacles”, Langmuir (2007), 23, 17231734 A. Perentes and P. Hoffmann, “Focused electron beam induced deposition of Si-based materials from SiOxCy to stoichiometric SiO2: Chemical compositions, chemical-etch rates, and deep ultraviolet optical transmissions”, Chemical Vapor Deposition (2007), 13, 176-184 D. R. Barbero, M. S. M. Saifullah, P. Hoffmann, H. J. Mathieu, D. Anderson, G. A. C. Jones, M. E. Welland, and U. Steiner, “High resolution nanoimprinting with a robust and reusable polymer mold”, Advanced Functional Materials (2007), 17, 2419-2425

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Current Group Research Interests Beam induced surface structuring and 3D deposition of nano-materials. Focus on micro and nano structuring 5 PhD Students of substrates and functional materials by etching and deposition techniques. By studying the underlying 2 Scientific Collaborators processes, we are developing novel enabling structuring technologies. In more detail, focused electron beam induced deposition of materials (FEB), patterned laser beam induced deposition of different oxides and their mixtures, and other non classical UV Excimer laser applications and chemical coating processes are investigated.

2007-2009 Patents P. Hoffmann, “Recovery of Si from sawing waste”: WO2009081245-A1 T. Bret, P. Hoffmann, M. Rossi, X. Multone, “Beam-induced etching of material on substrate involves directing gaseous compound which reacts in the presence of beam to etch the excess material which not etching the substrate”: EP1710327-A3 Teaching Activities Microengineering Chemistry of surfaces (SMT) Laser micro-machining training course (SMT) Micro- and nano-machining of materials by lasers Nano-machining of materials by focused charged particle beams Nanotechnology I (SMX SPH SMT SEL) Nanotechnology II (SPH SMT)

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Group Hongler Max-Olivier Hongler, Adjunct Professor Director of doctoral program in Manufacturing and robotics Formed as a theoretical physicist, (Phd from University of Geneva in 1981), postoctoral fellow (univ. Austin - Texas-USA) and Univ. Toronto - Canada), senior scientist (Univ. of Lisbon - Portugal) and invited Prof (Univ Bielefeld - Germany), I came to EPFL in 1990 where I developed a research activity in the modeling of manufacturing systems and production lines. I did supervise 5 EPFL-doctorate, (entirely sponsored by the Swiss National Fundation). One thesis was awarderd the ABB prize for research in 2002. While I permanently pay a great attention to promote research themes with close industrial relevance, my research activity is focused on mathematical approaches inspired from statistical and non-linear physics. Several of my results are now introduced in my regular teaching activity. Keywords: Operational research for manufacturing systems. http://lpm.epfl.ch/ Research Interests Operations research, (manufacturing and productiion) Non-linear dynamics and optimal control, (multi-agents systems) Applied probability and stochastic processes

2007-2009 Significant Publications O. Gallay and M.-O. Hongler , “Circulation of autonomous agents in production and service networks ”, Int. J. of Production Economics (2009), in press (see Scopus) J. Rodriguez and M.-O. Hongler, “Network of Mixed Canonical-Dissipative Systems and Dynamics Hebbian Learning”, Int. J. Comput. Intelligence,2(2) (2009), 140-146 O. Gallay and M.-O. Hongler, “Market sharing dynamics between two service providers ”, Europ. J. Operational Research, 190(1) (2008), 241-254 R. Filliger, M.-O. Hongler and L. Streit, “Connection between an exactly solvable stochastic optimal control problem and a nonlinear reaction-diffusion equation ”, J. of Optim. Theory, 137(2) (2008), 497-505 O. Gallay and M.-O. Hongler, “Cooperative dynamics of loyal customers in queueing networks”, J. Syst. Science and Syst. Engineer. (2008), 241-254 M-O. Hongler and P.R. Parthasarathy, “On a super-diffusive, nonlinear birth and death process”, Phys. Letters A, 372(19) (2008), 3360-3362 Ph. Blanchard and M.-O. Hongler, “Modeling Human Activity in the Spirit of Barabasi’s Queueing Systems”, Phys. Rev. E, 75(2) (2007), 026102

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2007-2009 External Grants received at the EPFL NSF 2007-2009

CHF 100’000

Collaborations & Networks Universiät Bielefeld (Germany) Dpt Theoretical Physics - co-direction of doctoral thesis in this institution Steering comittee member of the Europ. Science Found. (ESF), project entitled: Exploring the physics of small devices (started april 2009). Associate Editor of the IEEE Trans. on Industrial Informatics (since 2008). Teaching Activities Systèmes vibratoires Modélisation Dynamique Gestion des réseaux d’entreprises et “supply chain management”.

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Laboratory of Microengineering for Manufacturing 1 Jacques Jacot, Full Professor Jacques Jacot has over three decades of research and teaching experience from various corporate and academic institutions. He was previously in several SME acting as a director. Prof. Jacot holds a Master in mechanical engineering from EPFL. Keywords: assembly, visionsystems, manufacturing. http://lpm.epfl.ch/

2007-2009 Significant Publications P. Roduit, “ Trajectory analysis using point distribution models, ”, Ph.D. Thesis (2009), M. Bellino, “Multi-experts scheduling system for real-time applications, ”, Ph.D. Thesis (2009), F. Seigneur,, “Encapsulation hermétique pour systèmes hydro- et thermo-sensibles, ”, Ph.D. Thesis (2009), F. Seigneur, Y. Fournier, T. Maeder, P. Ryser and J. Jacot, “Hermetic package for optical MEMS”, Ceramic Interconnect and Ceramic Microsystems Technologies (CICMT) (2008), pp. 627-633 T. Lochmatter, P. Roduit, C. Cianci, N. Correll, J. Jacot and A. Martinoli, “SwisTrack - A Flexible Open Source Tracking Software for Multi-Agent Systems I ”, Proceedings of the IEEE/RSJ international Conference on Intelligent Robots and Systems (IROS 2008) (2008), pp. 4004-4010 P. Roduit, A. Martinoli and J. Jacot, “A Quantitative Method for Comparing Trajectories of Mobile Robots Using Point Distribution Models”, Proc. of the 2007 IEEE/RSJ Int. Conf. on Intelligent Robots and Systems (IROS 2007) (2007), pp. 24412448 F. Seigneur, Y. Fournier, T. Maeder and J. Jacot, “Laser soldering of LTCC hermetic packages with minimal thermal impact (EMPC)”, Proceedings, 16th IMAPS European Microelectronics & Packaging Conference (EMPC), Oulu, Finnland, (2007), pp. 526-530 F. Bourgeois, “Vers la maîtrise de la qualité des assemblages de précision, ”, Ph.D. Thesis (2007),

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Research Interests - Product conception, process control, industrialisation and tolerancing - Research & development for new attachement and optimized assembly technics applied to submillimetric scale - Optical and vision systems for assembly and quality control - Aesthetic quality control for high-end products - Robust signal processing algorithms and efficient real-time DSP software for optimized implementation in embedded systems.

Current Group 1 Adjunct Professor 1 Postdoctoral Fellow 6 Scientists 1 Scientific Collaborator 4 Scientific Advisers 16 PhD Students 2 Engineers 2 Technician Apprentices The research activities in the team cover a wide range of domains and they are published in many different 1 Trainee journals. Among them: Mikroproduktion; Revue polytechnique; Bulletin de la société suisse de chronométrie; 4 Technicians Electronic Letters on Computer Vision and Image Analysis; IEEE transactions on pattern analysis and 6 Laboratory Assistants machine intelligence.

Collaborations & Networks - Watch industries in Switzerland - Micro-mechanical industry - Automotive companies in Europe Most of the research projects originate from the numerous contacts established since a long time with the local industry. They involve leading companies or institutions working in micro-mechanical, vision, audio, medical, or domains. Teaching Activities Conception de produits I II Techniques d’assemblage I II Méthodes de production Industrialisation

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Group Jacquot Pierre Jacquot, Adjunct Professor Born in 1947 in Besançon, where he also graduates with Masters in Physics in 1970, and PhD in Physics in 1973. Joined the EPFL in 1974. In 1978 he is nominated as chargé de cours, he received the title of Adjunct Professor in 1996. Keywords: interferometry, speckle metrology, fringe pattern processing, optical trapping and binding, holography. http://nam.epfl.ch/research/99.html

2007-2009 Significant Publications P. Jacquot, P. Slangen, D. Borza, “Eléments d’interférométrie speckle”, Traité MIM, M. Grédiac Ed., Hermés Scientifique Lavoisier (2009), Chap. 5, 28 p. P. Jacquot, “Techniques speckle: théorie et applications”, Méthodes et Techniques Optiques pour l’Industrie, CMOI-SFO ed., ISBN 978-2-918241-00-3 (2009), Chap. 3, 106 p. S. Equis, P. Jacquot, “A new application of the Delaunay triangulation: the processing of speckle interferometry signals”, Proceedings of Fringe’09, Springer Ed. (2009), 8 p. S. Equis, and P. Jacquot, “The empirical mode decomposition: a must-have tool in speckle interferometry?”, Opt. Express (2009), 611-623 P. Jacquot, “Speckle interferometry: a review of the principal methods in use for experimental mechanics applications”, Strain (2008), 57-69 S. Equis and P. Jacquot, “Phase extraction in dynamic speckle interferometry by Empirical Mode Decomposition and Hilbert transform”, Strain (2008), 9 p. J.-M. Fournier, F. Merenda, J. Rohner, R.-P. Salathé, and P. Jacquot, “Optical micromanipulation of mesoscopic objects in microfluidic devices”, Proceedings ISFV13-13th International Symposium on Flow Visualization (2008), 10 p. J.-M. Fournier, F. Merenda, J. Rohner, P. Jacquot, and R.P. Salathé, “Comparison between various types of multiple optical tweezers”, Optical Trapping and Optical Micromanipulation, Proc SPIE Vol. 7038 (2008), 1-14 2007-2009 Awards Pericles Theocaris award, EURASEM 2007-07-04 “For outstanding contributions in the field of optical methods of experimental mechanics”

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Research Interests - correlation properties of speckle field - phase extraction of speckle interferometry signals and phase reconstruction algorithms - new optical methods and arrangements for full-field measurements - trapping and binding in multiple interferometric traps Many disciplines, in the laboratories or in industry, require very powerful investigation means. In fine, experimentations, and subsequently measurements, are at the heart of almost all scientific and engineering activities. Scientists clearly call for measurements techniques exhibiting higher and higher throughputs in numerical format, better spatial, temporal and measurement resolutions. The general research orientation of our group is to cope with this demand by resorting to optical full-field methods, which, a priori, fulfil these requirements. Our focus is double. On the one hand, we concentrate on photo-mechanics, to help to solve problems in structural behaviour and material properties identifications, conformity of mechanical tests, nondestructive testing. On the other hand, our major developments are in speckle interferometry and fringe projection, including the study of the correlation properties of speckle fields and the phase extraction of the interferometric signals. As a by-product of our realisations in interferometry, we are also interested in trapping and biding microscopic particles in 3D fringe patterns.

Collaborations & Networks - scientific committee member of CMOI, EURASEM organizations, and of SPIE, ICEM, BSSM and diverse conferences - Editorial board member of Computational and Experimental Methods in Structures, Imperial College Press - member of OSA, SPIE, EOS, SFO, SVMT - scientific committee member and instructor of Ateliers Photomécaniques CNRS - participant in the GDR CNRS 25 19 Mesures de champs et identification en mécanique des solides - collaboration with IOA-EPFL (Salathé, Fournier, Sidler, Unser)

2007-2009 External Grants received at the EPFL SNSF/with IOA-EPFLcollabortion 2006-2007 SNSF(principal requerant) 2006-2008

Teaching Activities - Speckle Metrology PO-18 Doctoral School Photonics 2008 - 12 Topics in Optics (participation in the Salathé’s courses) Microtechnique, Bachelor, 2008 - Optical Full-field Methods of Measurement, Microtechnique, optional, master - Techniques Speckle : Théorie et Applications, Journée de formation CMOI, France - Mesure de forme et de déformation en lumière cohérente diffuse speckle - Applications en métrologie des interfaces, CHF 210’000 - Master recherche, CREST, Université de Franche-Comté, Belfort, France CHF 140’000 - Atelier Photomécanique 2007, CNRS, Saint-Etienne, France

SNSF(principal requerant) 2009

CHF 60’000

SNSF(co-requerant) 2006-2007

CHF 210’000

SNSF (co-requerant) 2009-2011

CHF 270’000

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Laboratoire d’optique biomédicale Theo Lasser, Full Professor Theo Lasser studied physics at the Fridericiana University, Karlsruhe, He joined the Institut de Recherches franco-allemand at SaintLouis, France as scientific collaborator, and in 1986 the research division of Carl Zeiss in Oberkochen, Germany. Here he developed various laser systems for medical application. From 1990 he directed the laser laboratory, medical division; from 1993 the Lasers for ophthalmology unit; from 1995 ophthalmology Carl Zeiss, Jena and from 1998 was director research Jena. During this time he developed numerous refractive instruments, biomicroscopes and retina cameras. In July 1998 he was nominated ordinary Professor of Optique Biomedicale, EPFL. Keywords: Functional imaging, Metabolic imaging, Single molecule detection, high resolution, non-linear microscopy, Optical Coherence Microscopy, Laser Doppler Imaging, Tissue optics. http://lob.epfl.ch

2007-2009 Significant Publications M. Villiger, J. Goulley, M. Friedrich, A. Grapin-Botton, P. Meda, T. Lasser and R. A. Leitgeb, “In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy ”, Diabetologia (2009), DOI 10.1007/s00125-009-1383-y A. Raabe, D. Van De Ville, M. Leutenegger, A. Szelényi, E. Hattingen, R. Gerlach, V. Seifert, C. Hauger, A. Lopez, R. Leitgeb, M. Unser, E.J. Martin-Williams and T. Lasser, “Laser Doppler imaging for intraoperative human brain mapping ”, NeuroImage (2009), 44(4), 1284-1289 F. Aguet, S. Geissbühler, I. Märki, T. Lasser and M. Unser, “Super-resolution orientation estimation and localization of fluorescent dipoles using 3-D steerable filters ”, Optics Express (2009), 17(8), 6829-6848 R. Michaely, A.H. Bachmann, M.L. Villiger, C. Blatter, T. Lasser and R.A. Leitgeb, “Vectorial reconstruction of retinal blood flow in three dimensions measured with high resolution resonant Doppler Fourier domain optical coherence tomography ”, Journal of Biomedical Optics (2007), 12(4), 041213 R. Robelek, M. Leutenegger, B. Wiltschi, E.S. Lemke, D. Oesterhelt, T. Lasser and E.K. Sinner, “In vitro synthesis of GPCRs in a solid supported planar lipid membrane system ”, Biophysical Journal (2007), 38A, Suppl. S K. Hassler, P. Rigler, H. Blom, R. Rigler, J. Widengren and T. Lasser, “Dynamic disorder in horseradish peroxidase observed with total internal reflection fluorescence correlation spectroscopy ”, Optics Express (2007), 15(9), 5366-5375 A. Bilenca, T. Lasser, A. Ozcan, R.A. Leitgeb, B.E. Bouma and G.J. Tearney, “Image formation in fluorescence coherence-gated imaging through scattering media ”, Optics Express (2007), 15(6), 2810-2821 A.H. Bachmann, M.L. Villiger, C. Blatter, T. Lasser and R.A. Leitgeb, “Resonant Doppler flow imaging and optical vivisection of retinal blood vessels ”, Optics Express (2007), 15(2), 408-422

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Research Interests LOB focuses on optical functional imaging applied to life sciences and medicine, specifically: Single molecule detection and imaging with enhanced confinement for biofunctionality studies, High lateral resolution and nonlinear microscopy for cell and tissue imaging, Optical Coherence Microscopy and Laser Doppler Imaging for medical application e.g. diabetes, neurosurgery, etc.

Current Group 3 Postdoctoral Fellows 6 PhD Students 1 Administrative Assistant 1 Scientific Collaborator 1 Technician 1 Master Student 1 Undergraduate Student 3 Student Assistants 2 Engineers

2007-2009 External Grants received at the EPFL SNF 2009-2012 Innogrant 2008-2009

2007-2009 Awards Swiss Technology Award, CTI 2007-03-14 Laser Doppler Imaging of Microcirculation. 2007-2009 Patents A. Serov and T. Lasser, “Instrument and method for high-speed perfusion imaging ”: WO2006111909 (A1) Ch. Hauger, W. Nahm, T. Lasser, M. Leutenegger, E.J. Martin-Williams, A. Lopez., “Method and apparatus for displaying the field of a brain of a patient and navigation system for brain surgery.”: US 2009/0054788 A1, EP 1982645, JP 2008-110323, DE 102007018641.1 T. Lasser, D. Van de Ville, E.J. Martin-Williams, M. Leutenegger, I. Maerki, M. Friedrich, M. Villiger. , “Functional Optical Coherent Imaging.”: PCT / IB 2008 / 052787 (10 July 2008)

CHF 90’000

FN 2007-2010

CHF 349’043

FN 2006-2007

CHF 127’674

EU 2008-2012

CHF 956’300

EU 2006-2009

CHF 607’600

EU 2006-2009

CHF 444’929

CTI 2009-2011

CHF 486’382

Carl Zeiss 2006-2007

CHF 176’700

Collaborations & Networks Various networks across Europe, South East Asia, India and North & South America. Teaching Activities Biomicroscopy I & II Photonics I & II Doctoral School - Microscopy

R. Leitgeb, A. Bachmann and T. Lasser, “Phase sensitive Fourier domain optical coherence tomography ”: EP1872084 Ch. Hauger, W. Nahm, T. Lasser, M. Leutenegger, E.J. Martin-Williams, A. Lopez., “System and Method for examining an object.": DE 102007048362.9, EP 2008/008547/WO, WO 2009/046985 A2 R. Leitgeb, T. Lasser, A. Bachmann, L. Steinmann and M. Villiger, “Optical imaging system with extended depth of focus ”: WO2007085992

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Nanophotonics and Metrology Laboratory Olivier J.F. Martin, Associate Professor Director of the doctoral program in Photonics Olivier J.F. Martin received the B.Sc. and Ph.D. degrees in physics in 1989 and 1994, respectively, from the Swiss Federal Institute of Technology, Lausanne (EPFL), Switzerland. In 1989, he joined IBM Zurich Research Laboratory, where he investigated thermal and optical properties of semiconductor laser diodes. Between 1994 and 1997 he was a research staff member at the Swiss Federal Institute of Technology, Zurich (ETHZ). In 1997 he received a Lecturer fellowship from the Swiss National Science Foundation (SNSF). During the period 1996-1999, he spent a year and a half in the U.S.A., as invited scientist at the University of California in San Diego (UCSD). In 2001 he received a Professorship grant from the SNSF and became Professor of Nano-Optics at the ETHZ. In 2003, he was appointed Professor of Nanophotonics and Optical Signal Processing at the Swiss Federal Institute of Technology, Lausanne (EPFL), where he is currently head of the Nanophotonics and Metrology Laboratory. Dr. Martin has organized several important conferences, including the EOS Topical Meeting on Molecular Plasmonics Devices and the 9th International Conference on Near-field Optics, Nanphotonics and Related Techniques in 2006. Dr. Martin has authored or co-authored over 110 scientific publications in peer-reviewed journals and over 150 conference proceedings and abstracts. He also holds a handful of patents and invention disclosures. In 1999 he received the Latsis University prize for contributions to the study of near-field optics and photonic bandgap structures. Keywords: plasmonics, nanophotonics, photonics, biosensors, metamaterials, modelling, nanofabrication, near-field optics. http://nam.epfl.ch

2007-2009 Significant Publications L. Huang, S.J. Maerkl, and O.J.F. Martin, “Integration of plasmonic trapping in a microfluidic environment”, Opt. Express (2009), vol. 17, p. 6018 W. Zhang, H. Fischer, R. Zenobi, and O.J.F. Martin, “Mode-selective surface-enhanced Raman spectroscopy using plasmonic dipole antennas”, J. Phys. Chem. C (2009), vol. 113, p. 14672 G. Baffou, C. Girard, E. Dujardin, G. Colas des Francs, and O.J.F. Martin, “Molecular quenching and relaxation in a plasmonic tunable system”, Phy. Rev. B (2008), vol. 77, p. 121101R G. Lévêque, and O.J.F. Martin, “Narrow-band multiresonant plasmon nanostructure for the coherent control of light: An optical analog of the xylophone ”, Phys. Rev. Lett. (2008), vol. 100, p. 117402 H. Fischer, and O.J.F. Martin, “Engineering the optical response of plasmonic nanoantennas”, Opt. Express (2008), vol. 16, p. 9144 A. Christ, O.J.F. Martin, Y. Ekincy, N.A. Gippius, and S.G. Tikhodeev, “Symmetry breaking in a plasmonic metamaterial at optical wavelength”, Nano Letters (2008), vol. 8, p. 2171 G. Colas des Francs, C. Girard, T. Laroche, G. Lévêque, and O.J.F. Martin, “Theory of molecular excitation and relaxation near a plasmonic device”, J. Chem. Phys. (2007), vol. 127, p. 034701 A. Christ, Y. Ekinci, H. H. Solak, N. A. Gippius, S. G. Tikhodeev, and O.J.F. Martin, “Controlling the Fano interference in a plasmonic lattice”, Phy. Rev. B (2007), vol. 76, p. 201405R 2007-2009 Awards Landry prize, EPFL 2007-01-01 E. Lamothe, “Calculs des forces générées par des plasmons de surface sur des nano-fils en or” Best poster, China Nano 2009 2009-09-01 W. Zhang and O.J.F. Martin, “Mode-selective surface-enhanced Raman spectroscopy using nanofabricated plasmonic dipole antennas”

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Research Interests The main focus of our research is nanophotonics: the study of the interaction of light with structures smaller than the wavelength, with special emphasis on plasmonics: the optics of metallic nanostructures. We try to pursue a broad research that includes modelling, nanofabrication and optical characterization. Applications of our work include optical signal processing, biosensors, and novel optical metamaterials.

2007-2009 External Grants received at the EPFL SNSF NCCR Nanosciences 2007-09

CHF 214’000

SNSF NCCR Nanosciences 2009-13

CHF 240’000

SNSF 2008-11

CHF 125’000

SNSF 2009-12

CHF 257’000

OFES 2009-12

CHF 182’000

EC 2009-12

CHF 300’000

CCMX and CSEM 2009-12

CHF 175’000

Current Group 3 Scientists 1 Engineer 1 Administrative Assistant 8 PhD Students 1 PhD Student (external)

Collaborations & Networks As initiator and chair of the COST Action MP0803, the Nanophotonics and Metrology Laboratory is strongly connected to the main laboratories active in plasmonics in Europe. On-going collaborations include the Chalmers University, CNRS, Konstanz University, Queen's University Belfast, University of Southampton, and University of Burgundy in Europe; Duke University and Peking University overseas. Several national projects include institutions such as Basel University, CSEM, ETHZ and PSI. Teaching Activities Prof. Olivier Martin teaches the following five courses: Electrotechnique I, Laboratoires d'Electrotechnique (in collaboration with C. Doré), Optique, Applied Photonics I, Nanophotonics and Plasmonics. As director of the doctoral program in photonics, he also puts quite some efforts into federating photonics throughout EPFL with actions such as the yearly EPFL photonics day and photonics BBQ; Prof. Martin has initiated and maintains the website photonics.epfl.ch.

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Group Mondada Francesco Mondada, Senior Scientist Dr. Mondada received his M.Sc. in micro-engineering in 1991 and his Doctoral degree in 1997 at EPFL. During his thesis he co-founded the company K-Team, being both CEO and president of the company for about 5 years. He is one of the three main developers of the Khepera robot, considered as a standard in bio-inspired robotics and used by more than 1,000 universities and research centers worldwide. Fully back in research in 2000 and after a short period at CALTECH, he has been the main developer of the s-bot platform, which was ranked on position 39 in the list of “The 50 Best Robots Ever” (fiction or real) by the Wired Journal in 2006. The SWARM-BOTS project was selected as FET-IST success story by the EU commission. He is author of more than 70 papers in the field of bio-inspired robotics and system level robot design. He is co-editor of several international conference proceedings. In November 2005 he received the “Swiss Latsis University prize”, worth 16,500 EUR, for his contributions to bio-inspired robotics. Keywords: miniature mobile robot design, mechatronics, swarm robotics, edutainment. http://lsro.epfl.ch/

2007-2009 Significant Publications Tâche, F., Fischer, W., Caprari, G., Siegwart, R., Moser, R. and Mondada, F., “Magnebike: A magnetic wheeled robot with high mobility for inspecting complex-shaped structures”, Journal of Field Robotics (2009), 431-452 Halloy, J., Sempo, G., Caprari, G., Rivault, C., Asadpour, M., Tache, F., Said, I., Durier, V., Canonge, S., Ame, J.M., Detrain, C., Correll, N., Martinoli, A., Mondada, F., Siegwart, R. and Deneubourg, J.-L., “Social Integration of Robots into Groups of Cockroaches to Control SelfOrganized Choices”, Science (2007), 1155-1158 Baldassarre, G., Trianni, V., Bonani, M., Mondada, F., Dorigo, M. and Nolfi, S. , “Self-Organised Coordinated Motion in Groups of Physically Connected Robots”, IEEE Transactions on Systems, Man and Cybernetics Part B : Cybernetics (2007), 224-239 2007-2009 Patents MOSER Roland Richard, FISCHER Wolfgang, TÂCHE Fabien, SIEGWART Roland, MONDADA Francesco, “Stabilization mechanism for an inspection robot”: 07110243.8 2007-2009 External Grants received at the EPFL Swisscom 2009

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CHF 30’000

SNF 2008-2010

CHF 116’000

EC 2008-2009

CHF 260’000

EC 2006-2010

CHF 600’000

EC 2008-2009

CHF 203’000

CTI 2006-2009

CHF 715’000

ALSTOM 2009

CHF 95’000

School of Engineering

Research Interests My core activity is in the design of mobile miniature robots from a mechatronic perspective. This activity imply research in robot hardware and software architecture, vertical integration of control algorithms, design methodologies exploiting specific phenomena such as morphological computation etc. Because robots can be applied in many areas, we are used to make our research in the frameworks of interdisciplinary collaboration projects where we can find synergies with chemists, biologists, artists, designers, architects or teachers, to cite some of them. This allow us to innovate, for instance, in robot-animal interactions, functional robot design, swarm robotics, integration of robots in our daily life and in educational programs. The resulting technology is applied in industrial collaborations or by spin-offs.

Current Group 1 Postdoctoral Fellow 6 PhD Students 5 Engineers 1 Senior Technician 1 Trainee 1 Administrative Assistant

Collaborations & Networks Ongoing financed collaborations with: Universities: IRIDIA, Institut de Recherches Interdisciplinaires et de Développements en Intelligence Artificielle Université Libre de Bruxelles (Belgium), IDSIA, Istituto Dalle Molle di Studi sull’Intelligenza Artificiale (Switzerland), CNR-ISTC, Consiglio Nazionale delle Ricerche - Institute of Cognitive Science and Technology (Italy), CENOLI, Center for Nonlinear Phenomena and Complex Systems, Université Libre de Bruxelles (Belgium), HEIG-VD, Haute Ecole d’Ingénierie et de Gestion du Canton de Vaud (Switzerland), UPC, Universitat Politecnica de Catalunya, Advanced Hardware Architectures (AHA) Group (Spain), UJF, Université Joseph Fourier Grenoble, Laboratory of Preclinical Neuroscience (France), IMA, Institute of Applied Mathematics, University of Lausanne (Switzerland), DMCS, Department of Microelectronics and Computer Science, Politechnika Lodzka (Poland), LIRMM, Laboratory of informatic, robotic and microelectronic of Montpellier (France) Companies: ALSTOM Power Service (Switzerland), CSEM Centre Suisse d’Electronique et de Microtechnique SA (Switzerland) Teaching Activities Course “microinformatique”, last semester bachelor in microengineering. Course on embedded system programming. Practical exercises on mobile robots. 6 credits, 168 hours in summer semester. Coordinator of the practical exercises “TP de robotique” for master students. Obligatory course for students in microengineering, option “Robotics and Autonomous Systems”. 2 credits, 56 hours winter semester.

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Integrated Actuators Laboratory Yves Perriard, Adjunct Professor Vice-Director of the IMT-NE Institute Yves Perriard was born in Lausanne in 1965. He received the M. Sc. in Microengineering from the Swiss Federal Institute of Technology - Lausanne (EPFL) in 1989 and the Ph D. degree in 1992. Co-founder of Micro-Beam SA, he was CEO of this company involved in high precision electric drive. Senior lecturer from 1998 and professor since 2003, he is currently director of Laboratory of Integrated Actuators. His research interests are in the field of new actuator design and associated electronic devices. Since 2009, he is appointed Vice-Director of the Microengineering Institute in Neuchâtel. Keywords: Electric drives, Linear transducers, Complex system optimization, Invasive blood pump, Piezo electric motors. http://lai.epfl.ch/

2007-2009 Significant Publications Fernandez, J.M. and Perriard, Y., “Optimization of a new type of ultrasonic linear motor”, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control (01/09/2008), 659 – 667 Markovic, M., Jufer, M. and Perriard, Y. , “Analytical Force Determination in an Electromagnetic Actuator”, IEEE Transactions on Magnetics (01/09/2008), 2181 – 2185 Markovic, M. and Perriard, Y. , “Analytical Solution for Rotor Eddy-Current Losses in a Slotless Permanent-Magnet Motor: The Case of Current Sheet Excitation.”, IEEE Transactions on Magnetics (01/09/2008), 386 – 393 Markovic, M. and Perriard, Y., “An analytical determination of eddy-current losses in a configuration with a rotating permanent magnet”, IEEE Transactions on Magnetics (01/09/2007), 3380-3386 Germano, P., Crivii, M., Demarco, D., Paratte, L., Marquis, R. and Perriard, Y., “Analysis and modeling of electrostatic discharge in a tactile glass featured watch”, IEEE Transactions on Industry Applications (01/09/2007), 1091-1098 Persson, J., Markovic, M. and Perriard, Y. , “A New Standstill Position Detection Technique for Nonsalient Permanent-Magnet Synchronous Motors Using the Magnetic Anisotropy Method”, IEEE Transactions on Magnetics (01/09/2007), 554-560 2007-2009 Awards Student awards of best teacher of the STI Faculty, AGEPOLY-EPFL 2005-09-01 Students of each Faculty designates the best teacher of the Faculty Senior member IEEE, IEEE 2005-11-01 Student awards of best teacher of the STI Faculty, AGEPOLY-EPFL 2006-09-01 Students of each Faculty designates the best teacher of the Faculty

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Research Interests The overall research objective of the laboratory is to establish the scientific base for the nest generation of actuators and contactless energy transfer in the fast-growing fields of transducers. The activities of the Integrated Actuators Laboratory (LAI) are focused on tracking and setting new trends in two domains: design of small electromechanical (micro and MEMS), piezoelectric moving devices (motors and actuators), and of systems for the contactless energy transfer. Constant contacts and feedbacks from our industrila partners enable us to keep staying at the cutting edge in these domains. This includes basic research in sensorless electronic devices. In the world of ever-miniaturizing industrial products, the motion devices have to be optimal from technical (mass, volume, efficiency), industrial (simplicity, riability) and economical (price) point of view. This is always confronted with other constraints imposed by the device specifications (high speed, more than one degree of freedom, strong thermal and mechanical constraints).

2007-2009 Patents J. Persson, M. Markovic, Y. Perriard, “A Method and Device to Estimate the Position of a Rotor in a Permanent Magnet Synchronous Machine”: Pending L. Cardoletti, Y. Perriard, “Method and Device for Controlling a Synchronous Motor with Permanent Magnet”: Japon JP G7P004Y, USA US 09/529,039 L. Cardoletti, Y. Perriard, “Procédé et dispositif de commande d’un moteur synchrone à aimant permanent”: Europe Patent No EP 98944947.5 F. Bonvin, L. Cardoletti, Y. Perriard, “Procédé de détermination de la position du rotor d’un moteur électromagnétique sans collecteur et dispositif pour sa mise en oeuvre”: EU. Patent No 00810479.6-1522

Current Group 10 PhD Students 1.9 Senior Scientists 1 Scientific Collaborator 2 Laboratory Assistants 0.4 Administrative Assistant

CTI KABA AG 2007-2008

CHF 280’000

CTI Felco SA 2009-2011

CHF 278’000

CTI ETA SA 2006-2008

CHF 523’000

Collaborations & Networks Member of the Executive Council of the EPE Association, European Power Electronics, Brussels Past-President of the EPFL School Council (Assemblée d’Ecole) Expert RTD’ evaluator To the European Commission under 5th and 6th Program Expert for the Government of the Region Wallone in Belgium Member of the Steering committee of the IEMDC-IEEE Conference Member of the Steering committee of the ELECTRIMACS-TC1 Conference

V. Mosimann, L. Cardoletti, Y. Perriard, “Pièce à main dentaire motorisée Associate Editor IEE Journal of Electrical Engineering munie d’un accessoire électrique tel qu’un éclairage”: EP 0 688 539 B1 Associate Editor of IEEE Transactions on Industry Applications 2007-2009 External Grants received at the EPFL Schneider Electric SA (FR) 2008-2009

EU FP7 Airbus Project 2009-2010

CHF 135’000 Teaching Activities Actuator control by way of a microprocessor [fr] (SMT SEL) CHF 25’000 Electromechanics I [fr] (SMT SEL) Electromechanics II TP [fr] (SEL) CHF 180’000 Electromechanics conversion I [fr] (SMT) Electromechanics conversion II [fr] (SMT) CHF 336’000 Electromechanics conversion, Laboratory Work [fr] (SMT) Electrotechnics I [fr] (SMT) CHF 75’000 Electrotechnics II [fr] (SMT) Integrated transducers and drives [fr] (SMT SEL) CHF 150’000 Modeling of dynamic systems [fr] (SGM SMT)

CTI Sonceboz SA 2008-2010

CHF 310’000

CTI Solar Impulse 2006-2008

CHF 510’000

CTI Logitech SA 2008-2010

CHF 270’000

CTI KABA II AG 2009-2010

CHF 185’000

Patek Philippe 2009 MMT SA (FR) 2007-2009 Logitech SA 2008-2010 Interreg III 2008-2009

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Microsystems Laboratory 3 Radivoje Popovic, Full Professor Radivoje S. Popovic received the Dipl. Ing. degree in engineering physics from the University of Beograd, Yugoslavia in 1969, and the M.Sci. and Dr.Sci. degrees in electronics from the University of Nis, Yugoslavia in 1974 and 1978. From 1969 to 1981, he worked for Elektronska Industrija in Nis, Yugoslavia; and from 1982 to 1993, he was with Landis & Gyr AG, Central R&D in Zug, Switzerland, where 1991 he was appointed vice president Central R&D. In 1994 he joined Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland, as professor for microtechnology systems. Dr Popovic is author or co-author of 250 publications and 100 patent applications. He is founder of start-up companies Sentron AG, Sentronis AD, Senis GmbH, Ametes AG, Sensima Technology SA, and Sensima Inspection Sarl. He is member of Swiss Academy of Engineering Sciences and of Serbian Academy of Engineering Sciences. Keywords: Magnetic Optical Sensors. http://lmis3.epfl.ch/

2007-2009 Significant Publications M. Lany, G. Boero, R. S. Popovic, “Electron counting at room temperature in an avalanche bipolar transistor”, Appl. Phys. Lett. 92 (2008), 022111 P.D. Dimitropoulos, P.M. Drljaca, R.S. Popovic, P. Chatzinikolaou, “Horizontal HALL devices: A lumped-circuit model for EDA simulators”, Sensors and Actuators A , 161 (2008), 145-146 K. Ehrmann, N. Saillen, F. Vincent,M. Stettler,M. Jordan,F. M. Wurm, P.A. Besse and R. Popovic, “Microfabricated solenoids and Helmholtz coils for NMR spectroscopy of mammalian cells”, Lab on Chip 7 (2007), 373-380 O. Zorlu, P. Kejik, R. S. Popovic, “An orthogonal fluxgate-type magnetic microsensor with electroplated Permalloy core ”, Sensors and Actuators A, 135 (2007), 43-49 P. Kejik, P. Drljaca, R. S. Popovic, “Integrated Hall Microsystem with Current Re-Use ”, Sensor Letters, vol. 5 (2007), 42-44 D. Popovic, S. Dimitrievic, M. Blagojevic, P. Kejik, E. Schurig, R. S. Popovic, “Three-Axis Teslameter With Integrated Hall Probe”, IEEE Transactions on Instrumentation and Measurement, 56 (2007), 1396-1402 J. Sherman, J. Lubkert, R. Popovic, and M. DiSilvestro, “Characterization of a Novel Magnetic Tracking System”, IEEE Transactions on Magnetics, 43 (2007), 2725-2727 2007-2009 Patents MOSER ROLAND RICHARD; REVAZ BERNARD; REYMOND SERGE; KEJIK PAVEL; POPOVIC RADIVOJE, “METHOD FOR DETERMINING GEOMETRIC CHARACTERISTICS OF AN ANOMALY IN A TEST OBJECT AND MEASURING APPARATUS FOR CARRYING OUT THE METHOD”: US2009108838 (A1) Mirjana Banjevic, Radivoje Popovic, “FIELD SENSOR MEASURING A DIRECTION OF A MAGNETIC FIELD IN A PLANE AND CURRENT SENSOR”: PCT/EP2009/054225 POPOVIC RADIVOJE; KEJIK PAVEL; REYMOND SERGE, “Magnetic field sensor for measuring a direction of a magnetic field in a plane”: EP20070109063 20070529 Marc Lany, Radivoje Popovic, “Semiconductor device for measuring ultra small electrical currents and small voltages”: EP 1 936 390 A1

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Research Interests New effects and concepts for sensor devices, interface electronics, and integration of sensors and electronics; particularly, pushing the limits of the known and possible in the field of integrated magnetic and optical sensors. Current projects: - Integrated Hall magnetic sensors for better current and angular position sensing, - Integrated single photon counting avalanche diodes for future lidar applications, - Integrated single electron bipolar avalanche transistors for very fast electronics in the sub-picoamp current range.

2007-2009 External Grants received at the EPFL Toyota Motor Corporation, Japan 2007 - 2010

CHF 484’774

Swiss National Foundation 2006 - 2009

CHF 131’500

RUAG Aerospace, Nyon 2007 - 2008

CHF 155’000

Marie-Curie Industry Academia 2008 - 2010

CHF 177’000

Hamamatsu Photonics, Solid State Division, Japan 2005 - 2008

CHF 240’000

CTI - LEM SA 2008 - 2011

CHF 192’000

Commission of the European Communities 2007 - 2010

CHF 761’360

Asahi KASEI Electronics Co. Ltd, Japan 2007 ALSTOM (Switzerland) Ltd., Baden 2008

Current Group 2 Lecturers 1 Senior Scientist 1 Research Associate 3 Scientists 2 Research Assistants 4 PhD Students

CHF 62’000 CHF 102’000

Teaching Activities Courses: Analysis of products and systems [fr]; Integrating sensors with electronics [en]; Micro-magnetic field sensors and actuators [en]; Microelectronics [en]; Microelectronics and microsystems lab I and II [fr]

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Optics Laboratory Demetri Psaltis, Full Professor (STI/SV) Dean, School of Engineering Demetri Psaltis is the Dean of the School of Engineering and a Professor of Engineering and Life Sciences at the Ecole Polytechnique Fédérale de Lausanne, Switzerland. He graduated from Carnegie-Mellon University with a BS in Electrical Engineering and Economics in 1974, a MS degree in 1975, and a PhD in Electrical Engineering in 1977. In 1980, he joined the Electrical Engineering faculty at the California Institute of Technology in Pasadena, California and he served as Executive Officer for the Computation and Neural Systems department from 1992-1996. From 1996-1999 he was the Director of the National Science Foundation research center on Neuromorphic Systems Engineering at Caltech. From 2004-2008, he was the Director of the DARPA research center for Optofluidic Integration at Caltech. In 2007, he moved to the Ecole Polytechnique Fédérale de Lausanne, Switzerland. At EPFL since 2007 Keywords: optofluidics, nanoparticles, nonlinear optics, second harmonic, biophotonics, holography. http://lo.epfl.ch/

2007-2009 Significant Publications Chia-Lung Hsieh, Rachel Grange, Ye Pu, Demetri Psaltis, “Three-dimensional harmonic holographic microscopy using nanoparticles as probes for cell imaging”, Optics Express (2009 February), Vol. 17, pp. 2880-2891 Wuzhou Song, Andreas E. Vasdekis, Zhenyu Li, Demetri Psaltis, “Low-order distributed feedback optofluidic dye laser with reduced threshold”, Applied Physics Letters (2009 February ), Vol. 94, Article #051117 Wuzhou Song, Andreas E. Vasdekis, Zhenyu Li, Demetri Psaltis, “Optofluidic evanescent dye laser based on a distributed feedback circular grating”, Applied Physics Letters (2009 April ), Vol. 94, Article #161110 Zhenyu Li, Demetri Psaltis, “Optofluidic dye lasers”, Microfluidics and Nanofluidics (2008 January), Vol. 4, pp. 145-158 Zahid Yaqoob, Demetri Psaltis, Michael S. Feld, Changhuei Yang, “Optical phase conjugation for turbidity suppression in biological samples”, Nature Photonics (2008 February), Vol. 2, pp. 110-116 Ye Pu, Martin Centurion, Demetri Psaltis, “Harmonic holography: a new holographic principle”, Applied Optics (2008 February), Vol. 47, pp. A103-A110 Xiquan Cui, Lap Man Lee, Xin Heng, Weiwei Zhong, Paul W. Sternberg, Demetri Psaltis, Changuei Yang, “Lensless highresolution on-chip optofluidic mocroscopes for Caenorhabditis elegans and cell imaging”, PNAS (2008 August), Vol. 105, pp. 10670-10675 David A. Boyd, James R. Adleman, David G. Goodwin, Demetri Psaltis, “Chemical Separations by Buddle-Assisted Interphase Mass-Transfer”, Analytical Chemistry (2008 April ), Vol. 80, pp. 2452-2456 2007-2009 Awards Chia-Lung Hsieh, 2009-06-14 “Barium titanate nanoparticles as second harmonic radiation imaging probes”, Best student presentation, The 12th Topical Meeting on “Photorefractive Materials, Effects, and Devices - Control of Light and Matter” , NCCR 2007-2009, CHF 76’700.

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Current Group Research Interests The Optics Laboratory is mainly active in optofluidic devices, second harmonic imaging applications with 4 PhD Students 4 Postdoctoral Fellows nanoparticles as biomarkers and nonlinear optics. 1 Administrative Assistant Optofluidics: Fluids are used to synthesize novel optical systems. The optical properties of fluids can be modified by chemical synthesis relatively easily and the insertion of fluids in the optical path specifies or adapts the functionality of the optical system. One of the approaches we are pursuing is the integration of microfluidic circuits with photonic structures that contain voids into which fluids are injected. Imaging applications with nanoparticles: Second harmonic generation (SHG) from nanoparticles can be used as contrast markers to label biological cells and allow for better detection techniques. In contrast to fluorescent markers limited by photobleaching, Second Harmonic Radiation IMaging Probe (SHRIMP) emits a stable signal over a long time owing to the lack of real energy state transition. Moreover the coherent nature of SHG enables us to capture three-dimensional information in single frame by recording hologram at the doubled optical frequency. Nonlinear optics: We are studying theoretical and experimental nonlinear propagation of femtosecond pulses in 3D media. The nonlinearity produces very distinctive diffraction patterns such as self focusing and solitary waves. The research is mainly on nonlinear optics with evanescent waves, filament formation, modulation and transverse instabilities.

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Microsystems Laboratory 4 Philippe Renaud, Full Professor Scientific director of CMI Philippe Renaud received his diploma in physics from the University of Neuchâtel (1983) and his Ph.D. degree from the University of Lausanne (1988). He was postdoctoral fellow at University of California, Berkeley (1988-89) and then at the IBM Zürich Research Laboratory in Switzerland (1990-91). In 1992, he joined the Sensors and Actuators group of the Swiss Center for Electronics and Microtechnology (CSEM) at Neuchâtel, Switzerland. He was appointed assistant professor at EPFL in 1994 and full professor in 1997. In summer 1996, he was visiting professor at the Tohoku University, Japan. Ph. Renaud is active in several scientific committee (scientific journals, international conferences, scientific advisory boards of companies, PhD thesis committee). He is also co-founder of the Nanotech-Montreux conference and founding member of MSN conference (which is now Nanotech in USA). Ph. Renaud is committed to valorization of basic research through his involvement in several high-tech start-up companies. Keywords: BioMEMS, microfluidics, cell chips, bioelectronics, biosensors. http://lmis4.epfl.ch/

2007-2009 Significant Publications N. Durand and P. Renaud, “Label-free determination of protein-surface interaction kinetics by ionic conductance inside a nanochannel”, Lab on a Chip (2009), vol. 9, no. 2, pp. 319-324 L. Metref, F. Bianchi, V. Vallet, N. Blanc, R. Goetschmann, and P. Renaud, “Microfluidic system based on thermoexpandable polymer for on chip blood coagulation testing”, Micro and Nanosystems (2009), vol. 1, no. 1, pp. 41-45 S. Gawad, M. Giugliano, M. O. Heuschkel, B. Wessling, H. Markram, V. Schnakenberg, P. Renaud, and H. Morgan, “Substrate arrays of iridium oxide microelectrodes for in-vitro neuronal interfacing”, Frontiers in Neuroengineering (2009), vol. 2, pp. 1.1-1.7 T. Braschler, N. Demierre, E. M. Nascimento, A. G. Oliva, and P. Renaud, “Continuous separation of cells by balanced dielectrophoretic forces at multiple frequencies”, Lab on a Chip (2008), Vol. 8, no. 2, pp. 280-286 A. Ginggen, Y. Tardy, R. Crivelli, T. Bork, and P. Renaud, “A telemetric pressure sensor system for biomedical applications”, IEEE Transactions on Biomedical Engineering (2008), vol. 55, no. 4, pp. 1374-1381 A. Mercanzini, K. Cheung, D. L. Buhl, M. Boers, A. Maillard, P. Colin, J.-C. Bensadoun, A. Bertsch, and P. Renaud, “Demonstration of cortical recording using novel flexible polymer neural probes”, Sensors and Actuators A: physical (2008), vol. 143, no. 1, pp. 90-96 N. Durand, A. Bertsch, M. Todorova, and P. Renaud, “Direct Measurement of Effective Diffusion Coefficients in Nanochannels Using Steady-State Dispersion Effects”, Applied Physics Letters (2007), vol. 91, p. 203106

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Current Group 3 Master Students 4 Postdoctoral Fellows 10 PhD Students 1 Erasmus student 0.5 Administrative Assistant Cell-Chips With the combination of microfluidics and microelectrodes, we are studying new types of Cell-Chip devices 2 Senior Scientists in which we can manipulate, analyze, and modify biological cells. Cells are analysed by impedance 1 Visiting Student spectroscopy while flowing through micro-channels. The objective is to achieve in-situ cell separation after 2 Engineers electrical identification. The same device can also be used for controlled manipulation or single cell electrotransfection. Recently, we have developed a new technique for entrapping cells in polymer gels directly in micro-channels. This offers the possibility to generate gel structures with layers of different cells for the study of behaviour in various biochemical environments and cell-cell interactions. Research Interests The research of our group is related to the exploitation of miniaturization to address new applications in life sciences and other fields. We apply technologies and develop understanding of related physical phenomena in small scale devices. We are currently focusing on three main areas of research:

Teaching Activities 2007-2009 External Grants received at the EPFL SysX - WingX 2008 - 2012 CHF 246’000 for LMIS Capteurs, 4h/week, 3rd year MT, EL, MX (joint teaching with Dr. G. Boero) Stoicescu Fondation 2009 - 2011 CHF 225’000 BioMEMS, 2h/week, master MT et SV SNF - CRSI20_122698 -SAMS 2009 -2012 CHF 185’000 for LMIS Microsystèmes-lois d’échelle, 2h/week, master MT, EL, MX (joint teaching with Pr. H. Shea) SNF - 315200_114152 - Retina III 2007 - 2009 CHF 127’000 for LMIS Physiologie Instrumentation, 2h/week, master MT, minor BM (joint teaching with Pr. K. Aminian) SNF - 200020_121572 - Nanoslit II 2008 - 2010 CHF 134’000 Scaling in MEMS, 1 credit EDOC NanoTera - SiMos 2009 -2012 NanoTera - Livesense 2009 -2012 EURO FP7 - Nanobe 2009 - 2012 ESA - 21014 - MicroMag 2008

CHF 240’000 for LMIS TP Microsystèmes, 4h week, master MT (joint supervision with Pr. Popovic) CHF 600’000 for LMIS (tot: 2’874’000) TP BioMEMS, lab practice in life sciences, 1.5 days, master SV CHF 256’000 for LMIS CHF 30’000 for LMIS (tot: 75’000)

CTI - 9847 - CLS24 II 2009 - 2010

CHF 96’000 for LMIS

CTI - 9077.1 - CLS24 2008

CHF 220’000 for LMIS (tot: 453’000)

CTI - 9044 -RBC 2008 - 2010

CHF 360’000 for LMIS (tot: 657’000)

CTI - 8913 - Sigatec 2007 - 2009 CCMX - Papamod 2008 - 2009

EPFL minor in Biomedical Technology: coordinator

CHF 310’000 CHF 130’000 for LMIS (tot: 260’000)

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Laboratory of Microengineering for Manufacturing 2 Peter Ryser, Associate Professor Dr. Peter Ryser is a Professor of Microengineering at the Swiss Federal Institute of Technology in Lausanne. He has over three decades of research and teaching experience from various corporate and academic institutions. He was previously a Director at Siemens Building Technologies where he was responsible for R&D, product innovation and patents. Dr. Ryser has a Ph.D. in applied Physics from the University of Geneva, a Masters degree in Experimental Physics and an MBA. Keywords: Product conception, Microsystem packaging, biomedical sensors. http://lpm.epfl.ch/ Research Interests Product development, micro system packaging, thick film technology

2007-2009 Significant Publications Ambrosetti, G (Ambrosetti, Gianluca); Johner, N (Johner, Niklaus); Grimaldi, C (Grimaldi, Claudio); Danani, A (Danani, Andrea); Ryser, P (Ryser, Peter), "Optimal percolation of disordered segregated composites", PHYSICAL REVIEW E, 79 (2): Art. No. 020104 Part 1 FEB 2009 (), Maeder, T (Maeder, Thomas); Affolter, G (Affolter, Gregory); Johner, N (Johner, Niklaus); Corradini, G (Corradini, Giancarlo); Ryser, P (Ryser, Peter), "Optimisation of a thick-film 10-400 N force sensor", MICROELECTRONICS RELIABILITY, 48 (6): 902-905 JUN 2008 (), Johner, N (Johner, N.); Grimaldi, C (Grimaldi, C.); Balberg, I (Balberg, I.); Ryser, P (Ryser, P.), "Transport exponent in a three-dimensional continuum tunneling-percolation model", PHYSICAL REVIEW B, 77 (17): Art. No. 174204 MAY 2008 (), Johner, N (Johner, N.); Ryser, P (Ryser, P.); Grimaldi, C (Grimaldi, C.); Balberg, I (Balberg, I.), "Piezoresistivity and tunneling-percolation transport in apparently nonuniversal systems", PHYSICAL REVIEW B, 75 (10): Art. No. 104204 MAR 2007 (), Birol, H (Birol, Hansu); Maeder, T (Maeder, Thomas); Nadzeyka, I (Nadzeyka, Ingo); Boers, M (Boers, Marc); Ryser, P (Ryser, Peter), "Fabrication of a millinewton force sensor using low temperature co-fired ceramic (LTCC) technology", SENSORS AND ACTUATORS A-PHYSICAL, 134 (2): 334-338 MAR 15 2007 (), Birol, H (Birol, H.); Maeder, T (Maeder, T.); Ryser, P (Ryser, P.), "Application of graphite-based sacrificial layers for fabrication of LTCC (low temperature co-fired ceramic) membranes and micro-channels", JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 17 (1): 50-60 JAN 2007 (), Barraud, A (Barraud, Antoine); Kunzi, S (Kuenzi, Simon); Meurville, E (Meurville, Eric); Rougnon, JP (Rougnon, Jean-Pierre); Maeder, T (Maeder, Thomas); Kowlessur, S (Kowlessur, Sadasing); Latin, P (Latin, Pierre); Gyger, M (Gyger, Marcel); Ryser, P (Ryser, Peter); Takano, N (Takano, Nao); Straessler, S (Straessler, Sigfrid); Robin, F (Robin, Franck), "In-vivo studies of a long-term implantable glucose monitoring sensor based on a rheological technique", DIABETES, 57: A551-A552 Suppl. 1 JUN 2008 (),

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2007-2009 External Grants received at the EPFL KTI Precimed 2008

CHF 49’660

FP7 Have-it 2008-2012

CHF 897’750

FN Synergia HA 2009-2012

CHF 299’594

FN Oritran 2007-2008 FN nanoterra Simos 2009-2012

CHF 45’288 CHF 292’000

FN Conper 2009-2011

CHF 97’775

CTI HTPS 2007-2009

CHF 738’000

CTI Grapoly 2008-2009

CHF 679’820

Collaborations & Networks Microengineering Industry in Switzerland Start-up companies Medical instrumentation companies European automotive supplier industries CTI /SNF /FP7 nanoterra project leader Teaching Activities Product conception Industrialisation L’ingénieur dans le R&D industriel

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Advanced Photonics Laboratory René Salathé, Full Professor René Paul Salathé is Professor of Applied Optics and Director of the Advanced Photonics Laboratory at EPF Lausanne. He is presently also a member of the Life Sciences expert team at the Swiss Innovation Agency CTI in Bern and of the Kuratorium at the Fraunhofer Institut für Lasertechnik ILT in Aachen. René Paul Salathé received the MS, PhD, and Habilitation (Privatdozent) degrees at the University of Bern in 1970, 1974, and 1979, respectively. Prior to his appointment at EPFL in 1989, he was directing the division "Material Testing and Technology" at the research and development center of the Swiss PTT. He has been active in the fields of semiconductor lasers, fibers, integrated optics, laser processing, and biomedical optics. The results of his research activities have been published more than 250 scientific contributions and 36 PhD theses at EPFL. Several start-up companies have been founded based on patents elaborated in his laboratory and/or by his PhD students. Keywords: Lasers, Optics,Sensors. http://apl.epfl.ch/

2007-2009 Significant Publications F. Merenda, M. Grossenbacher, S. Jeney, L. Forro, and R. P. Salathe, “Three-dimensional force measurements in optical tweezers formed with high-NA micromirrors”, Optics Letters 34 (2009), 1063-1065 R. de Oliveira, S. Lavanchy, R. Chatton, D. Costantini, V. Michaud, R. Salathe, and J. A. E. Manson, “Experimental investigation of the effect of the mould thermal expansion on the development of internal stresses during carbon fibre composite processing”, Composites Part A: Applied Science and Manufacturing 39 (2008), 1083-1090 J. M. Fournier, F. Merenda, J. Rohner, P. Jacquot, and R. P. Salathe, “Comparison between various types of multiple optical tweezers”, SPIE WA 98227-0010 (2008), 70381 F. Merenda, J. Rohner, J. M. Fournier, and R. P. Salathe, “Miniaturized high-NA focusing-mirror multiple optical tweezers”, Optics Express 15 (2007), 6075-6086 F. Gardillou, Y. E. Romanyuk, C. N. Borca, R. P. Salathe, and M. Pollnau, “Lu, Gd codoped KY(WO4)(2): Yb epitaxial layers: towards integrated optics based on KY(WO4)(2)”, Optics Letters 32 (2007), 488-490 Absence of UV-induced stress in Bragg gratings recorded by high-intensity 264 nm laser pulses in a hydrogenated standard telecom fiber, “H. G. Limberger, C. Ban, R. P. Salathe, S. A. Slattery, and D. N. Nikogosyan”, Optics Express 15 (2007), 5610-5615 G. Boer, R. Johann, J. Rohner, F. Merenda, G. Delacre taz, P. Renaud, and R.P. Salathe, “Combining multiple optical trapping with microflow manipulation for the rapid bioanalytics on microparticles in a chip”, Review of Scientific Instruments 78 (2007), 116101 Y. Tissot, H. G. Limberger, and R. P. Salathe, “Ultrawide bandwidth wavelength monitor based on a pair of tilted fiber Bragg gratings”, IEEE Photonics Technology Letters 19 (2007), 1702-1704 2007-2009 Patents F. Merenda, J. Rohner, and R. Salathe, ‘Miniaturized optical tweezers based on high NA micromirrors’: WO 2008/012767 A2 G. Boer, F. Merenda, G. Delacrétaz, and R. Salathe, ‘Miniaturized optical tweezers array with an array of reflective elements for reflecting the light back to the focal area’: WO 2007/042989 A1 B. Rachet, F. Merenda, and R. Salathe, ‘Focusing micromirror array scanner for polychromatic, large-field and high-resolution microscopy and microlithography’: PCT/IB2009/050285

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Research Interests laser tweezers, optical sensor applications, integrated optics, laser processing

2007-2009 External Grants received at the EPFL SNF 2006-2007 SNF 2007-2009 SNF 2009-2010 Medtronic 2008 Intel Corp 2005-2007 ESA 2007-2009 CTI 2008-2010 CTI 2009-2010 CTI 2009-2010

Current Group 3 Postdoctoral Fellows 2 Group Leaders 2 PhD Students 1 Senior Technician 1 Engineer

Teaching Activities CHF 130’000 Bachelor level: 2007 and 2008 Lectures and Exercices on ‘Optics’ CHF 130’000 Master level: CHF 150’000 2007 and 2008 Lectures ‘Laser’ together with T. Sidler, 2009 Lectures ‘Laser’ given by T.Sidler and T. Kippenberg CHF 26’000 2008 Lectures ‘Integrated Optics’ together with Hans Limberger 2007-2009 TP ‘Optics’ together with T. SidlePHD level: CHF 337’000 2007-2009 supervision of 7 thesis CHF 480’000 Doctoral School in Photonics: 2007 Lectures on ‘Coherent Imaging’ together with Christian CHF 660’000 Depeursinge 2007 and 2009 Lectures on ‘Waveguide Lasers’ given by H. Limberger CHF 90’000 2008 Lectures on ‘Fiber Devices’ given by H. Limberger CHF 93’000 Doctoral School in Material Sciences: 2007 and 2009 Lectures on ‘Laser micro-processing’ T. Sidler and P.Hoffmann

Collaborations & Networks - joint experiments in the framework of COST Action MP0604 on ‘Optical Micro-Manipulation By Nonlinear Nanophotonics’: - on ‘Laser Trapping and Raman Measurements’ with Prof. Dimitri Petrov and Dr. R. Satish The Institute of Photonic Sciences, Barcelona, Spain - on ‘Trapping with white light’ with Prof. K. Dholakia, University of St. Andrews, UK - joint experiments on ‘hollow core fibers and fiber tweezers’ with Prof. Ken Oh, Yonsei University, Seoul, South Korea - joint experiments on ‘Chromium and Bismuth doped optical fibers’ with Academician E. Dianov at Fiber Optic Research center at Russian Academy of Sciences (FORC-RAS), - joint experiments on ‘Welding of pacemakers with multi-sensor control’ with Dr S. Favre, Medtronic, Tolochenaz, - joint experiments within the project ‘Optical Ground Service Equipment for ALFA-project’ with Dr. M. Schillinger, Dr N. Riguet of ESA/Astrium SAS, Toulouse, France and Dr. A. Hélière, ESA, Noordwijk, Netherlands - Informal collaborations on ‘Stress measurements in optical fibers’ with J. Albert, Carlton University, Ottawa, Canada and D. Nikogosyan, Univ. Cork, Ireland

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Groupe Seitz Peter Seitz, Adjunct Professor 1975-1984: MSc. and Ph.D. in Physics, Swiss Federal Institute of Technology (ETH) Zurich 1984-1987: Staff Member, RCA Research Laboratories, Princeton (New Jersey) and Zurich 1987-1997: Group Leader, Paul Scherrer Institute, Zurich 1997-2000: Section Head, Image Sensing, CSEM SA, Zurich 2000-2004: Vice President Photonics, CSEM SA 2004-2005: Head Science & Technology, Swissnex, scientific annex to the consulate general of Switzerland, San Francisco, California 2005-2007: Vice President Academic Relations, CSEM SA 2007-today: Vice President Nanomedicine, CSEM SA 1998-today: Professor, Institute for Microtechnology, University of Neuchatel Peter Seitz has authored or co-authored more than 180 scientific publications, conference papers and book chapters. He has been distinguished with 20 national and international awards; the most prestigious being the 2004 Grand Prize of the European Commission's Information Society Technology Award (endowed with 200,000 Euro). He holds 35 international patents. Keywords: Semiconductor image sensors, Photonic microsystems, Organic semiconductors, Polymer optoelectronics. http://esplab.epfl.ch/

2007-2009 Significant Publications N. Blanc, P. Giffard, P. Seitz, P. Buchschacher, V. Nguyen, M. Hoheisel, "Semiconductor Image Sensing", More than Moore (Springer, Massachusetts) (2009) P. Seitz, "Nanophotonics for Lab-on-Chip Applications", LNICST Lecture Notes on NanoBiophotonics (Springer, Berlin) (2009) P. Seitz, "Optical Biochips", Biophotonics (Springer, Berlin) (2008), 217-237 B. B端ttgen and P. Seitz, "Robust Optical Time-of-Flight Range Imaging Based on Smart Pixel Structures", IEEE Transactions on Circuits and Systems, Vol. 55 (2008), 1512-1525 P. Seitz, "Quantum-Noise Limited Distance Resolution of Optical Range Imaging Techniques", IEEE Transactions on Circuits and Systems, Vol. 55 (2008), 2368-2377 M. Ramuz, L. B端rgi, C. Winnewisser and P. Seitz, "High sensitivity organic photodiodes with low dark currents and increased lifetimes", Organic Electronics, Vol. 9 (2008), 369-376 B. Hosticka, P. Seitz and A. Simoni, "Optical TOF Sensors for Solid-State 3D Vision", Encyclopedia of Sensors, Vol. 7 (2007), 259-290 B. B端ttgen, M.-A. El Mechat, F. Lustenberger and P. Seitz, "Pseudo-Noise Optical Modulation for Real-Time 3D-Imaging with Minimum Interference", IEEE Transactions on Circuits and Systems, Vol. 54 (2007), 2109-2119 2007-2009 Patents P. Seitz and F. Lustenberger, "Photosensor with low noise and high dynamic range": US 7,550,705 P. Seitz, "Colorimetric three-dimensional microscopy": US 60/839,424 P. Seitz, "Imaging optical coherence tomography with dynamic coherent focus": US 60/833,810 P. Seitz, "Human Interaction Trainer and Facilitator": US 60,780,977 P. Seitz and C. Urban, "Optical profiler using low-coherence light": US 11/881,444 P. Seitz and A. Falhi, "Method and apparatus for acquiring long-exposure images without motion artifacts": PCT/EP 2009/057602 P. Seitz, "Solid-state photosensor with electronic aperture control": EP 1,624,491

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Research Interests Current Group Semiconductor image sensors. Smart pixels. High-performance photosensing. Low-noise, high-speed and 5 PhD Students high-dynamic-range image sensing. Photonic microsystems. Optical metrology and measurement systems. Optical time-of-flight 3D range cameras. Organic semiconductors. Polymer optoelectronics. Monolithic photonic microsystems based on organic semiconductors. Entrepreneurship, management, creativity, intellectual property and project management.

P. Seitz and J. NĂźesch, "Authentication method of packaged goods": EP 09156340.3 Ch. Lotto and P. Seitz, "Charge pulse detecting circuit": EP 08169759.1 P. Seitz, "Charge sampling device and method": EP 08168070.4 Ch. Lotto and P. Seitz, "Highly sensitive solid-state image sensor": EP 08163384.4 P. Seitz and St. Beer, "Electrical circuit, apparatus and method for the demodulation of an intensity-modulated signal": CN 100,477,490C Collaborations & Networks Vice President Nanomedicine CSEM SA, CH-Landquart Editor-in-Chief, SENSORS, CH-Basel Member, Swiss Academy of Technical Sciences (SATW) Member, Steering Committee NRP-62, Swiss National Science Foundation Board Member European Optical Society, D-Hannover Board Member, Stakeholders in Photonics, B-Brussels Chairman of the Board, Dynetix AG, CH-Landquart Chairman of the Board, Heliotis AG, CH-Root Chairman of the Board, SwissTom AG, CH-Landquart Member of the Board, Espros Photonics Corp., CH-Sargans Member of the Board, Zentronica AG, CH-Lucerne Teaching Activities Solid-State Image Sensing, Doctoral School of Photonics, EPFL 2009 Entrepreneurship, Master Course, Uni Neuchatel 2007 and 2008 Solid-State Imaging - Architectures and Techniques, Master Course, EPFL 2007 Management of R&D Projects, Bachelor Course, Uni Neuchatel 2007 and 2008 Semiconductor Photosensors, Master Course, Uni Neuchatel 2007 and 2008

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Microsystems for Space Technologies Laboratory Herbert Shea, Tenure Track Assistant Professor Education PhD, Physics, Harvard University, 1997 MA, Physics, Harvard University, 1993 BSc, Physics, McGill University, 1991 Professional experience - Assistant Professor, Tenure Track, EPFL, 2004 - present - Technical Manager, MEMS Reliability Group, Bell Labs, Lucent Technologies, 2001-2004 - Member of Technical Staff, Bell Labs, Lucent Technologies, 1999-2001 - Postdoctoral Fellow, IBM TJ Watson Research Center Yorktown Heights, NY, USA, 1997-1999 Keywords: MEMS, Space, Electric propulsion, Artificial Muscle, Dielectric Elastomer Actuator, Chip-scale Plasma, inertial sensing, Tunable Optics, Polymer MEMS, Radiation Hardness of MEMS, Picosatellites. http://lmts.epfl.ch/

2007-2009 Significant Publications R. Krpoun, K. L. Smith, J. P. W. Stark, and H.R. Shea, “Tailoring the hydraulic impedance of out-of-plane micromachined electrospray sources with integrated electrodes”, Applied Physics Letters (2009), vol. 94, p. 163502 R. Krpoun and H. Shea, “Integrated out-of-plane nanoelectrospray thruster arrays for spacecraft propulsion ”, Journal of Micromechanics and Microengineering (2009), vol 19, p. 045019 S. Rosset, M. Niklaus, P. Dubois, H. R. Shea, “Metal Ion Implantation for the Fabrication of Stretchable Electrodes on Elastomers”, Advanced Functional Materials (2009), Vol 19, p. 470 P. Dubois, S. Rosset, M. Niklaus, M. Dadras, H.R. Shea, “Voltage Control of the Resonance Frequency of Dielectric Electroactive Polymer (DEAP) Membranes”, IEEE/ASME Journal of Microelectromechanical Systems (2008), Vol .17, pp 1072 S. Rosset , M. Niklaus, P. Dubois, and H. R. Shea, “Mechanical Characterization of a Dielectric Elastomer Microactuator With Ion-Implanted Electrodes”, Sensors and Actuators A (2008), 144, pp.185 Niklaus, S. Rosset, P. Dubois, M. Dadras, and H. Shea, “Microstructure of 5 keV Gold implanted Polydimethylsiloxane ”, Scripta Materialia (2008), vol 59 , pp. 893 M. Bodendorfer, K. Altwegg, P. Wurz, H. Shea, “Identification of the ECR zone in the SWISSCASE ECR ion source”, Nuclear Instruments and Methods in Physics Research Section B (2008), Vol. 266, Iss 21 pp 4788 R. Krpoun and H.R. Shea, “A method to determine the onset voltage of single and arrays of electrospray emitters”, Journal of Applied Physics (2008), vol 104, p. 064511 2007-2009 Patents E. Charbon, R. Krpoun, N. Scheidegger, H. Shea, “Method and apparatus to determine a planet vector”: US application# 20080177473

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Research Interests The mission of the Microsystems for Space Technologies Laboratory’s (EPFL-LMTS) is to develop reliable MEMS for use in Spacecraft as well as on Earth. Our activities cut across several MEMS technologies, both silicon and polymer based. Since the lab was founded in 2004, a major focus has been on miniaturized electroactive polymer (EAP) actuators fabricated using low-energy metal ion implantation in silicone elastomers. This research has led to miniaturized EAP device with the largest reported percentage displacement, to flexible metal electrodes conducting reliably at strains greater than 175%, and to arrays of EAP devices on a chip, including tunable lenses, and devices applying cyclic stress on single cells. We have developed two types of Earth Sensors for use on satellites, one based on imaging atmospheric oxygen airglow, the other based on directly measuring the gravity gradient vector using a MEMS pendulum, thus allowing the spacecraft to determine its orientation with respect to the Earth without optical access. We are investigating chip scale plasma light sources to be used in miniature atomic clocks, and have demonstrated the first mmscale hermetically sealed plasma fabricated at the wafer-scale. We demonstrated a highly efficient compact and integrated MEMS thruster (electric propulsion) which can be tuned to emit either ions or charged droplets. We are actively pursuing the development of this thruster in collaboration with an international consortium. Our laboratory was instrumental in starting the SwissCube project, a 1 kg satellite designed and built primarily at the EPFL, with launch planned in August 2009. The LMTS was responsible for the payload which will demonstrate one of our novel Earth sensor concepts.

Current Group 2 Postdoctoral Fellows 4 PhD Students 0.3 Administrative Assistant

Collaborations & Networks The EPFL-LMTS collaborates with the European space agency (ESA) and with European space industry to develop micro-propulsion systems, in particular with TNO in the Netherlands and with Nanospace in Sweden. In the field of optical coherence tomography (OCT), we have a joint research with the IIT Madras in India, entailing the exchange of personnel and devices. We have ongoing work with UCSB on cell sorting. Within Switzerland, we work closely with the CSEM on MEMS reliability, with the ETHZ on cell cytomechanics,and with Swiss space industry (Oerlikon Space, Sercalo Microtechnology) on optical switching and instruments for satellite navigation. Teaching Activities I teach two classes in the Microengineering department (“section Microtechnique”), both at the Master’s level. 2007-2009 External Grants received at the EPFL Swiss State Secretariat for Education and Research 2009-2012 Swiss National Science Foundation 2006-2008 & 2008-2010 & 2009-2012 Fondation en faveur d’un Laboratoire de Recherches Horlogères (FLRH) 2008

1. MEMS Reliability. Covers the different aspects of the reliability of MEMS devices, from materials to design to packaging. CHF 254’000 2. Scaling in MEMS (with Prof. Renaud). Overview of the dominant physical effects and scaling of laws when downsizing sensors and actuators. Shows the limits and breakdown of scaling laws. CHF 609’000 CHF 50’000

European Space Agency (ESA), 6 projects 2006-2009

CHF 582’000

European Commission (FP7) 2006-2009

CHF 150’000

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Biomedical Imaging Laboratory Michael Unser, Full Professor Director of CIBM signal processing core Michael Unser received the M.S. (summa cum laude) and Ph.D. degrees in Electrical Engineering in 1981 and 1984, respectively, from the EPFL. He spent 13 years working as a scientist with the National Institutes of Health, Bethesda MD, before being appointed professor at the EPFL in 1997. His main research topics are biomedical image processing, splines and wavelets. He has published over 150 journal papers, and is one of ISI’s Highly Cited authors in Engineering. Dr. Unser is a fellow of the IEEE, and the recipients of three IEEE- SPS Best Paper Awards. Keywords: Biomedical imaging, image processing, splines, wavelets, inverse problems. http://bigwww.epfl.ch/

2007-2009 Significant Publications D. Van De Ville, M. Unser, “False Discovery Rate for Wavelet-Based Statistical Parametric Mapping”, IEEE J. Sel. Topics in Sig. Proc. (12/2008), 897-906 D. Van De Ville, M. Unser, “Complex Wavelet Bases, Steerability, and the Marr-Like Pyramid”, IEEE TIP (11/2008), 206380 S. Ramani et al., “Monte-Carlo SURE: A Black-Box Optimization of Regularization Parameters for General Denoising Algorithms”, IEEE TIP (09/2008), 1540-54 F. Aguet et al., “Model-Based 2.5-D Deconvolution for Extended Depth of Field in Brightfield Microscopy”, IEEE TIP (07/2008), 1144-53 C.S. Seelamantula et al., “Exact and Efficient Signal Reconstruction in Frequency-Domain Optical-Coherence Tomography”, JOSA A (07/2008), 1762-71 I. Khalidov et al., “BSLIM: Spectral Localization by Imaging with Explicit B0 Field Inhomogeneity Compensation”, IEEE TMI (07/2007), 990-1000 O. Bernard et al., “Variational B-Spline Level-Set: A Linear Filtering Approach for Fast Deformable Model Evolution”, IEEE TIP (06/2009), 1179-91 F. Aguet et al., “Super-Resolution Orientation Estimation and Localization of Fluorescent Dipoles Using 3-D Steerable Filters”, Optics Express (04/2009), 6829-48 P.D. Tafti et al., “Invariances, Laplacian-Like Wavelet Bases, and the Whitening of Fractal Processes”, IEEE TIP (04/2009), 689-702 P. Thévenaz, M. Unser, “Snakuscules”, IEEE TIP (04/2008), 585-93 T. Blu, M. Unser, “Self-Similarity: Part II—Optimal Estimation of Fractal Processes”, IEEE TSP (04/2007), 1364-78 M. Unser, T. Blu, “Self-Similarity: Part I—Splines and Operators”, IEEE TSP (04/2007), 1352-63 C. Vonesch, M. Unser, “A Fast Multilevel Algorithm for Wavelet-Regularized Image Restoration”, IEEE TIP (03/2009), 50923 S. Ramani et al., “Nonideal Sampling and Regularization Theory”, IEEE TSP (03/2008), 1055-70 C.Ó.S. Sorzano et al., “Elastic Image Registration of 2-D Gels for Differential and Repeatability Studies”, Proteomics (01/2008), 62-5

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Research Interests The Biomedical Imaging Group (BIG) pursues research on the development of new algorithms and mathematical tools for the advanced processing of medical and biological images. Topics of interest are image reconstruction, multi-modal imaging, image analysis and visualization. Research efforts are taking place at two complementary levels: (i) fundamental and mathematical aspects of imaging; and (ii) applicationoriented projects in collaboration with researchers in medicine and biology. The strength of this group lies in the strong interaction between theory and practice, and the use of sophisticated mathematics for solving concrete problems in biomedical imaging. Our priority is to develop algorithms that respond to specific needs of the biomedical community. In many cases, these are incorporated into userfriendly software that is made available to researchers over the web.

Current Group 10 PhD Students 3 Postdoctoral Fellows 2 Research Assistants 1 Senior Technician 1 Administrative Assistant 3 Scientific Advisers

2007-2009 Awards Elected Member, Swiss Academy of Engineering Sciences. 2007-01-01 Technical Achievement Award, IEEE Signal Processing Society. 2008-01-01 Fellow, EURASIP. 2009-01-01 Collaborations & Networks Centre d’imagerie biomédicale (CIBM-EPFL-UNIGE): Profs. Thiran, Gruetter, Lazeyras SystemX-DynamicX: Prof. Maerkle Dr. Patrick Hunziker, Kardiologie, Kantonsspital, Basel EPFL optical imaging: BiOP center, Profs. Salathé, Lasser, Depeursinge Teaching Activities Image Processing I Image Processing II Signaux et systèmes I (microtechnique) Signaux et systèmes I (sciences de la vie) Signaux et systèmes II (microtechnique) Signaux et systèmes II (sciences de la vie)

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Interfaculty Institute of Bioengineering

Laboratory of Movement Analysis and Measurement Kamiar Aminian, Adjunct Professor Kamiar Aminian received the electrical engineering degree in 1982 and the Ph.D. degree in biomedical engineering in 1989 from Ecole Polytechnique Fédérale de Lausanne (EPFL). He worked as a Research Associate in the Metrology Laboratory, EPFL and as an Assistant Professor at Sharif University of Technology, Tehran, Iran. In January 2002, he joined the School of Engineering of EPFL where he is currently Professor of medical instrumentation with the Interfaculty Institute of Bioengineering and the Center Interinstitutional of Translational Biomechanics. Keywords: Biomechanics, Sport, Inertial sensors, Wearable systems, System integration, Clinimetry, Orthopaedics engineering. http://lmam.epfl.ch/

2007-2009 Significant Publications B. Najafi, J. Helbostad , R. Moe-Nilssen, W. Zijlstra, K. Aminian , "Does walking strategy in older people change as a function of walking distance?", Gait & Posture (2009), 261-266 B. Coley, BM. Jolles, A. Farron, K. Aminian, "Arm position during daily activity", Gait & Posture (2008), 581–587 J. Favre, B.M. Jolles, R. Aissaoui, K. Aminian, "Ambulatory measurement of 3D knee joint angle", Journal of Biomechanics (2008), 1029-1035 A. Paraschiv-Ionescu, E. Buchser, B. Rutschmann, K. Aminian, "Nonlinear analysis of the human physical activity patterns in health and disease", Phys. Rev. E (2008), 77, 021913 B. Coley, BM. Jolles, A. Farron, C. Pichonnaz, JP Bassin, K. Aminian, "Estimating the upper-limb dominant segment during daily activity", Gait & Posture (2008), 368-375 H. Dejnabadi, BM Jolles, K. Aminian, "A New Approach for Quantitative Analysis of Inter-Joint Coordination during Gait", IEEE Transactions on Biomedical Engineering (2008), 755-764 A. Salarian, H. Russmann, F. Vingerhoets , P. R. Burkhard, K Aminian, " Ambulatory monitoring of physical activities in patients with Parkinson’s disease", IEEE Transactions on Biomedical Engineering (2007), 2296-2299 A. Salarian, H. Russmann, C. Wider, P. R. Burkhard, F. Vingerhoets , K Aminian, "Quantification of tremor and bradykinesia in Parkinson’s disease using a novel ambulatory monitoring system", IEEE Transactions on Biomedical Engineering (2007 ), 313-322 2007-2009 Awards Prix Venel, Swiss Society of Orthopedics 2008-00-00 Best swiss research team’s work in orthopedics Symposium DISS, Dép. interfacultaire de Sport et Santé, UNIL and Association Romande en Sciences du Sport 2008-11-00 Best paper 2007-2009 Patents A. Paraschiv-Ionescu, K. Aminian, E. Buchser, “Methods and device to quantify human physical activity pattern”: Patent no. 07113253.4-1526

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Current Group 1 M.D., Adjunct Professor 1 Administrative Assistant 1 Scientific Collaborator 2 Senior Technicians 2 Postdoctoral Fellows 7 PhD Students 4 Scientific Advisers 1 Trainee 3 Master Students 8 Undergraduate Students 4 Student Assistants

2007-2009 External Grants received at the EPFL Telethon Foundation 2007-2009 Swiss National Foundation, PNR53, 405340-104752/1/2 2004-2009 Swiss National Foundation, 325200-109401 2005-2007 Swiss National Foundation, 3200B0-120422 2008-2011 Swiss National Foundation, 3200B0-105880/1 2005-2007 Swiss National Foundation, 205321-120136 2008-2011

Collaborations & Networks CHF 104'600 Academic: Europe: University of Bologne, University of Groningen, University of Bergen, Université d’Aix-Marseille, Robert-BoschKrankenhaus, Hôpital Sainte Marguerite, USA/Canada: Rosalind CHF 505'421 Franklin University of Medicine & Science, Oregon Health and Science University, Université de Montréal, Stanford University, Asia/Africa: University of Tehran, Sharif University of Technology, Shibaura Institute CHF 120'000 of Technology, Health Research & Development Centre, Ifakara, Switzerland: ETHZ, UNIL, CHUV, Swiss Tropical Institute, Inselspital, HUG, CRR-SUVA, Kantonales Spital Sursee-Wolhusen, Swiss-ski, CHF 243'000 OFS (Macolin), EPFL: Signal Processing Laboratory 5, Microsystems Laboratory 2, Microsystems Laboratory 4, Electronics Laboratory 1, Geodetic Engineering Laboratory. Industry: Medtronic, Logitech, CHF 173'000 Proteor,GE Healthcare Findland Oy, IMEC (NL), ROLEX, Symbios, Telealarm CHF 259'569

Office Fédéral du sport Macolin 2007-2010

Teaching Activities CHF 540'000 Bachelor (EE program): 1) Measuring Systems, 2) Measuring Systems Labs CHF 41'275 Master (Biomedical Engineering): 1) Sensors in Medical CHF 224'900 Instrumentation, 2) Seminar in Physiology & Instrumentation

Kinetics Foundation, Oregon Health Science University 2006-2007

CHF 148'000

SImOS, nanotera program (SNF) 2009-2013 Proteor, France 2009-2010

Industry- Confidential 2007-2009 HOSR Foundation 2007-2009

CHF 51'500 CHF 600'000

Cooperation-Seed Money, EPFL 2006-2007

CHF 40'000

AREH 2005-2007

CHF 35'000

6th Framework Programme EU, Minami, 034690 2006-2009

Master (Thesis): 14 during the 5 past years Doctoral school (EDBB): Orthopedics Engineering,

CHF 124'000

6th Framework Programme EU, Liaison 2004-2007

CHF 45'600

6th Framework Programme EU, 02.0312-1 2003-2007

CHF 56'000

7th Framework Programme EU, 215493 2008-2010

Master (AISTS): Measuring techniques for sports

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Laboratory of Integrative and Systems Physiology Johan Auwerx, Full Professor (SV) Nestlé Chair in Energy Metabolism Doctor of Medecine Johan Auwerx received his M.D. in 1982 and his Ph.D. in Molecular Endocrinology in 1989 at the Katholieke Universiteit in Leuven, Belgium. He is a certified clinical specialist in Endocrinology, Metabolism and Nutrition and is currently professor at the Ecole Polytechnique Fédérale in Lausanne, Switzerland, where he heads a research group together with Dr. Schoonjans. Johan Auwerx is internationally known as an expert in metabolic diseases, molecular biology, and mouse molecular genetics. His work was instrumental for the development of agonists of the peroxisome prolifération activated receptors into drugs, which now are commonly used in the treatment of type 2 diabetes. He furthermore was amongst the first scientists to recognize the impact of the sirtuins and SRC/p160 gene family on metabolic homeostasis, suggesting that cofactors are valid targets to treat metabolic diseases. Dr. Auwerx spearheaded a unique large mouse phenogenomics program and was the director of the Strasbourg Mouse Clinical Institute from 2006 to 2008. Prof. Auwerx was elected as a member of EMBO in 2003. At EPFL since 01/09/2008 Keywords: Diabetes, Genetics, Metabolism, Metabolic Disease, Phenogenomics, Transcription. http://auwerx-lab.epfl.ch/

2007-2009 Significant Publications S. Heikkinen, C. Argmann, J.N. Feige, H. Koutnikova, M.F. Champy, N. Dali-Youcef, E.S. Schadt, M. Laakso, J. Auwerx. , “The Pro12Ala PPARg2 variant determines metabolism at the gene-environment interface.", Cell Metabolism (2009), 9, 88-98 C. Canto, Z. Gerhart-Hines, J.N. Feige, M. Lagouge, L. Noriega, J.C. Millne, P. Puigserver, J. Auwerx. , “AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.”, Nature (2009), 458, 1056-1060 R. Duggavathi, D.H. Volle, C. Mataki, M.C. Antal, N. Messadeq, J. Auwerx, B.D. Murphy, K. Schoonjans. , “Liver receptor homolog 1 is essential for ovulation.”, Genes Dev (2008), 22, 1871-1876. A. Coste, J.F. louet, M. Lagouge, C. Lerin, M.C. Antal, H. Meziane, K. Schoonjans, P. Puigserver, B. W. O’Malley, J. Auwerx, “The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1a.”, Proc Natl Acad Sci USA (2008), 105, 17187-17192 J.N. Feige, M. Lagouge, C. Canto, A. Strehle, S. Houten, J. Millne, P.D. Lambert, C. Mataki, P.J. Elliot, J. Auwerx, “Specific SIRT activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.", Cell Metabolism (2008), 8, 347-358 D. H. Volle, R. Duggavathi, B.C. Magnier, S.M. Houten, C. L. Cummins, J.-M. Lobaccaro, G. Verhoeven, K. Schoonjans, J. Auwerx, “The small heterodimer partner is a gonadol gatekeeper of sexual maturity in male mice.”, Genes Dev (2007), 21, 303-315 C. Mataki, B. Magnier, S.M. Houten, J.-S. Annicotte, C. Argmann, C. Thomas, H. Overmars, W. Kulik, D. Metzger, J. Auwerx, K. Schoonjans, “Compromised intestinal lipid absorption in mice with a liver-specific deficiency of the Liver Receptor Homolog 1.”, Mol Cell Biol (2007), 27, 8330-8339 F. Gofflot, N. Chartoire, L. Vasseur, S. Heikkinen, D. Dembele, J. Le Merre, J Auwerx. , “Systematic gene expression mapping clusters nuclear receptors on the basis of their function in the brain.”, Cell (2007), 131, 405-418.

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Research Interests The research of the Laboratory of Integrative and Systems Physiology (LISP) aims to understand how regulatory proteins, including nuclear receptors, membrane receptors and transcriptional cofactors, act as sensors for molecules of nutritional, metabolic or pharmacological origin, and translate this into altered gene expression and protein patterns affecting metabolic function. The Auwerx/Schoonjans laboratory was amongst the pioneers to unravel the wide-ranging implications of the three PPARs, PPARα, PPARβ/δ, and PPARγ, in metabolic control. Perhaps most striking in this context was our discovery of an association between the PPARγ Pro12Ala gene variant with type 2 diabetes and obesity, identified long before the era of genome-wide association studies, and as such the first gene tied with these common complex diseases. We established how the enterohepatic nuclear receptors, LRH-1 and SHP, govern hepatic lipid and bile acid metabolism, regulate mucosal immune homeostasis, and control fertility via their commanding role on steroid production. We furthermore identified bile acids as endocrine regulators of energy expenditure, through the activation of a novel membrane receptor, TGR5. Finally, We established that transcriptional cofactors, such as the acetyltransferases (SRC2/TIF2 and SRC-3) and the deacetylases (such as SIRT1), fine-tune energy homeostasis by changing the acetylation status of PGC-1α, the master regulator of mitochondria. Since altered signaling by nuclear receptors and cofactors, contributes to the pathogenesis of type 2 diabetes, obesity and atherosclerosis, our research paved the way for novel preventive and therapeutic strategies for these common diseases. The importance of these discoveries is testified by the fact that several compounds targeting these receptors and or cofactors have made it into the clinic. Examples of drugs for which our research contributed to clinical development are the fibrates (that target PPARα), thiazolidinediones (that target PPARγ), PPARβ/δ agonists, bile acids and bile acid derivatives (that target both the TGR5 and FXR), and resveratrol and SRT1720 (which activate SIRT1).

Current Group 2 PhD Students 10 Postdoctoral Fellows 1 Administrative Assistant 4 Technicians 1 Scientific Collaborator 2 Master Students 1 Visiting Student

2007-2009 External Grants received at the EPFL NIH 2009-2011

CHF 500’000

Fonds National Suisse (FNS) 2009-2012

CHF 755’000

Fonds National Suisse (FNS) 2009-2012

CHF 415’000

European Research Council (ERC) 2009-2014

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CHF 3’900’000

Stem Cell Dynamics Laboratory Yann Barrandon, Full Professor (SV) Member of the Ethical Committee Head of Joint Chair EPFL - CHUV - UNIL Prof. Barrandon trained as a dermatologist at Hospital St-Louis in Paris and completed his Ph. D."on the long term cultivation of human haematopoietic stem cells” in 1982 under the direction of Dr. Catherine Dresch (Centre Hayem, St Louis Hospital). He worked as a post-doctoral fellow (1982-1983) with Pr. Marvin Karasek in the Department of Dermatology at Stanford University CA, and then with Pr. Howard Green, a pioneer in cell therapy, in the Department of Molecular and Cellular Physiology at Harvard Medical School (1983-1990). During this period, he participated to the first transplantations of epidermal stem cells on extensive third degree wound and demonstrated by clonal analysis the presence of stem cells in cultured epithelium grafts. He also demonstrated in collaboration with Jeffrey Morgan and Pr Richard Mulligan at the Whitehead Institute for Biomedical Research (Massachussets Institute of Technology, Cambridge, USA) that human keratinocyte stem cells could be efficiently transduced by retroviral vectors. He has also participated to the transfer of the stem cell technology from Harvard University to a spin off biotechnology company now part of Genzyme. He returned to France in 1990 as Director of Research at the INSERM (National Institute of Heath and Medical Research) and Director of Laboratory at the Ecole Normale Supérieure, Paris. During this period, he demonstrated the presence of multipotent stem cells in hair follicles and successfully conducted a clinical trial demonstrating the usefulness of a fibrin matrix to transplant epidermal stem cells. Keywords: Stem cells, morphogenesis, microenvironment, plasticity, reprogramming, cell and gene therapy. http://ldcs.epfl.ch/

2007-2009 Significant Publications Bonfanti, P., Claudinot, S., Amici, A.W., Farley, F., Blackburn, C.C., Barrandon, Y., “Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells”, Nature (submitted), Gurtner, G.C., Werner, S., Barrandon, Y., Longaker, M.T., “Wound repair and regeneration”, Nature (2008), Vol 453, pp. 314-321 Majo, F., Rochat, A., Nicolas, M., Abou Jaoudé, G., Barrandon, Y., “Oligopotent stem cells are distributed throughout the ocular surface”, Nature (2008), vol 456, pp 250-254 Nakamura,T., Ohtsuka, T., Sekiyama,E., Cooper, L.J., Kokubu, H., Fullwood,N.J., Barrandon, Y., Kageyama, R., “Hes1 Regulates Corneal Development and the function of corneal epithelial stem/ progenitor cells”, Stem Cells (2008), Vol 26(5), pp 1265-1274 Feutz, A.C., Barrandon, Y., Monard, D. , “Control of thrombin signaling through P13K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells”, J.Cell Sci. (2008), vol 121, pp 1435-1443 P. Linderholm, J. Vannod, Y. Barrandon, and P. Renaud, “Bipolar resistivity profiling of 3D tissue culture”, Biosensors and Bioelectronics (2007), vol. 22, no. 6, pp. 789-796 Barrandon Y. , “Crossing Boundaries: stem cells, holoclones and the fundamentals of squamous epithelial renewal”, Cornea (2007), Vol 26, pp10-12 Barrandon Y., “Genetic manipulation of skin stem cells:success, hope and challenges ahead”, Mol. Ther. (2007), Vol15(3), pp443-444 Vauclair, S., Majo. F., Durham, A.D., Ghyselinck, N.B., Barrandon, Y., Radtke, F., “Corneal epithelial cell fate is maitained during repair by Notch 1 signaling via the regulation of vitamin A metabolism”, Dev.Cell (2007), vol 13(2), pp 242-253 2007-2009 Awards CTI - Medtech Award, CTI 2008-09-02 “Drug administration with a KISS” 2007-2009 Patents Barrandon Yann, Brouard Michel Azzabi Fahd, “Target of Rapamycin modulators of and use thereof”: C07K14/47; C12N15/86

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Research Interests The laboratory is developing research in the field of adult stem cells (tissue) using the skin of mammals as a model. Research projects range from understanding the basic biology of stem cells, their use in cell therapy and gene therapy.

Current Group 1 Group Leader 1 Scientific Collaborator 9 Postdoctoral Fellows 4 PhD Students Collaborations & Networks 2 Master Students Prof. Barrandon was a board member of the European Tissue Repair Society and he is now a board member 3 Technicians of TERMIS and of the International Society of Differentiation. Yann Barrandon is recognized as one of the 1 Administrative Assistant leading experts in his field and he has given more than 300 conferences worldwide on the basic and clinical 1 Senior Technician application of stem cells. He was a partner in EuroStemCell and Therapeuskin, two FP6- research consortia, and he is now a principal investigator in EuroSystem, OptiStem and Betacelltherapy, FP7- European research consortia. He was awarded the Eloi Collery Prize by the French Academy of Medicine in 2001 and the SV Best teacher award in 2006.

2007-2009 External Grants received at the EPFL Japanese-Swiss Science and Technology Cooperation 2009-2011 FNS : Sinergia pending 2009-2012

CHF 150’000 CHF 1’556’100

FNS : PNR63 pending 2010-202012

CHF 300’000

FNS 2007-2009

CHF 223’000

FNS pending 2010-2012

CHF 900’000

Eu - FP7 : Optistem 2009-2013

CHF 450’000

Eu - FP7 : EuroSystem 2008-2012

CHF 600’000

Eu - FP7 : Betacelltherapy 2010-2014

CHF 600’000

ERC Advanced Grant pending 2010-2014 CTI 2008-2010

CHF 3’726’000 CHF 300’000

Teaching Activities Advanced stem cell biology (EDNE) Developmental Biology I (SSV) Stem Cells (SSV SSIE SCGC) Stem cell biology (EDNE)

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Laboratory For Biomolecular Modeling Matteo Dal Peraro, Tenure Track Assistant Professor (SV) Matteo Dal Peraro graduated in Physics at the University of Padova, he obtained his Ph.D. in Biophysics at the International School for Advanced Studies (SISSA, Trieste, Italy) with Prof. P. Carloni, and received postdoctoral training under the guidance of Prof. M. L. Klein (University of Pennsylvania). In 2007 he was nominated Assistant Professor at the EPFL-School of Life Sciences. At EPFL since November 2007 Keywords: computational biophysics and structural biology; multi-scale molecular simulations; macro-molecular assembly; protein and drug design; high-performance computing. http://lbm.epfl.ch/

2007-2009 Significant Publications Khurana, E., Dal Peraro, M., DeVane, R.,Vemparala, S., DeGrado, W.F., Klein, M.L. , “Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus”, Proc Natl Acad Sci USA (2009), 106(4), 1069 –1074 S. Wagner, I. Sorg, M. Degiacomi, L. Journet, M. Dal Peraro and G.R. Cornelis, “The helical content of the YscP molecular ruler determines the length of the Yersinia injectisome”, Molecular Microbiology (2009), 692-701 M. De Vivo, M. Dal Peraro and M.L. Klein, “Phosphodiester Cleavage in Ribonuclease H Occurs via an Associative Two-Metal-Aided Catalytic Mechanism”, Journal of the American Chemical Society (2008), 130(33), 10955–10962 M. Cascella, M.A. Neri, P. Carloni and M. Dal Peraro, “Topologically based multipolar reconstruction of electrostatic interactions in multiscale simulations of proteins ”, Journal of Chemical Theory Computation (2008), 4(8), 1378–1385 M. Dal Peraro, A.J. Vila, P. Carloni and M.L. Klein, “Role of zinc content on the catalytic efficiency of B1 metallo beta-lactamases”, Journal of the American Chemical Society (2007), 129(10), 2808-16 M. Dal Peraro, K. Spiegel, G. Lamoureux, M.D. Vivo, W.F. DeGrado and M.L. Klein, “Modeling the charge distribution at metal sites in proteins for molecular dynamics simulations", J Struct Biol (2007), 157(3), 444-53

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Research Interests Current Group In the Laboratory for Biomolecular Modeling we use advanced molecular modeling techniques combined 2 Postdoctoral Fellows with high-performance computing to investigate biological systems, in particular their function emerging from 3 PhD Students structure. Our main targets are bacterial and viral systems and their mechanism of resistance towards natural and clinical drugs. We develop new multiscale schemes and models to extend the power of current molecular simulations to tackle problems such as the assembly of large macromolecular complexes and the design of remedies for pathogenic infections.

2007-2009 External Grants received at the EPFL SNF - Sinergia 2009-2012 (of 1’256’000) CHF 320’000 SNF 2008-2011

CHF 292’000

Collaborations & Networks He is actively involved in a network of local and international collaborations with computational and experimental groups. He collaborates within the domain of computational modeling with Prof. Klein (University of Pennsylvania), Prof. Cascella (University of Bern), Prof. Carloni (SISSA), and Prof. Hatzimanikatis (EPFL). Collaborations are also active with several experimental groups: Prof. van der Goot (EPFL), Prof. Maerkl (EPFL), Prof. Deplanke (EPFL), Prof. Cornelis (Biozentrum Basel), Prof. DeGrado (University of Pennsylvania), and Prof Vila (University of Rosario). Teaching Activities He is currently involved in the teaching activities of the bachelor in “Life Sciences & Technology" and the master programs in “Life Sciences & Technology" and “Bioengineering & Biotechnology". He is involved in the bachelor course in “Project design" and he will start in the academic year 2009-2010 a new course at the master level in “Biomolecular structure and mechanics".

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Laboratory of Systems Biology and Genetics Bart Deplancke, Tenure Track Assistant Professor (SV) Professional experience 2007 - Assistant Professor in Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Féderale de Lausanne (EPFL), Lausanne (Switzerland) 2003 - 2007 Postdoctoral Fellow, Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester (USA) 2002 - 2003 Postdoctoral Fellow, Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Genetics, Harvard Medical School, Boston, Massachusetts (USA) 1998 - 2002 Research Fellow, Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois (USA) Education 2002 - Ph.D. in Intestinal Immunobiology (Division of Nutritional Sciences), University of Illinois at Urbana-Champaign, USA 1998 - M.S. in Biochemical Engineering, Ghent University, Belgium 1995 - B.S. in Bio-engineering, Ghent University, Belgium. At EPFL since November 2007 Keywords: gene regulatory network, transcription, genomics, systems biology, high-throughput. http://deplanckelab.epfl.ch/

2007-2009 Significant Publications B. Deplancke, “Experimental advances in the characterization of metazoan gene regulatory networks.", Briefings in Functional Genomics and Proteomics (2009), 8:12-27 J.S. Reece-Hoyes*, B. Deplancke*, I. Barrasa, I. Hatzold, R. Smit, E. Arda, P. Pope, J. Gaudet, B. Conradt, A.J.M. Walhout. (*, shared first authorship), “The C. elegans Snail homolog CES-1 can activate gene expression by binding to an extended binding site, and share targets with bHLH transcription factors.", Nucleic Acid Research (2009), epub (doi:10.1093/nar/ gkp232) A. Mukhopadhyay*, B. Deplancke*, A.J. Walhout, H.A. Tissenbaum. (*, shared first authorship), “Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans.", Nature Protocols (2008), 3:698-709 V. Vermeirssen*, B. Deplancke*, I. Barrasa*, J.S. Reece-Hoyes*, N.J. Martinez, H.E. Arda, C.A. Grove, A.J.M. Walhout. (*, shared first authorship), “A C. elegans transcription factor array and Steiner Triple System-based smart pools: highperformance tools for transcription regulatory network mapping.", Nature Methods (2007), 4:659-664

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Research Interests Experimental systems biology: Reverse engineering of the gene regulatory networks that control differential gene expression in metazoan organisms, specifically the mouse and Drosophila, through (1) the large-scale experimental identification of regulatory elements that control metazoan gene expression as well as their associated TFs, (2) the development of innovative tools and resources to detect and monitor protein-DNA interactions in vivo. Computational systems biology: Modeling of the dynamic properties of core gene regulatory circuitries. Synthetic biology: Metazoan promoter design and analysis of combinatorial cisregulation.

2007-2009 External Grants received at the EPFL SystemsX.ch RTD Project (co-investigator) 2010-2014

CHF 4’500’000

SystemsX.ch iPhD Project 2008-2011

CHF 171’725

SNSF R’Equip 2008

CHF 270’000

SNSF Individual Project Grant 2008-2011

CHF 498’825

Merck-Serono (Co-investigator) 2008-2011

CHF 525’000

FP7 Marie Curie IRG 2008-2012

CHF 160’000

Flemish Scientific Fund 2009-2010

CHF 100’000

Collaborations & Networks (1) Dr. Andrew Oates (Max Planck Institute, Dresden): Mapping of zebrafish TF-protein and TF-DNA interactions; (2) Dr. Eileen Furlong (EMBL, Heidelberg): cis-regulatory module chacterization in Drosophila; (3) Dr. Stanislav Shvartzman (Princeton): Elucidation of the regulatory logic underlying shell development in Drosophila; (4) Dr. Patrick Callaerts (VIB, Leuven): Mapping Drosophila gene regulatory networks underlying neuroblast formation; Teaching Activities 2008 - International Genetic Engineering Competition (iGEM) Team EPFL Instructor 2008 - Functional Genomics Course Lecturer (PhD Course), EPFL, Switzerland

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Laboratory for Regenerative Medicine & Pharmacobiology Peter Frey, Adjunct Professor (Joint Affiliation CHUV) Doctor of Medecine Born in Basel on January 14, 1948, Peter Frey has studied medical zoology and immunology and qualified in these subjects at Basel University , prior to undertaking medical studies at the same establishment. He earned a medical degree in 1980 and went on to complete various internships at hospitals in Switzerland and abroad (Great Britain, Kenya, Sri Lanka and France). In 1987 he earned a PhD in medicine from Basel University and in 1988, he was accredited by the FMH Swiss Medical Federation as a specialist in pediatric surgery. In 1990 he was promoted Privat Docent at the University of Basel. He was further appointed senior lecturer and research fellow, as well as Privat Docent at Lausanne University (UNIL) in 2000, and associate professor of pediatric urology in 2003. Peter Frey has headed the pediatric urology unit at the University Hospital Center of the Canton of Vaud (CHUV) since 1994. From 1996-1997, he conducted several medical missions to Côte d’Ivoire, Benin and Togo for the “Terre des Hommes” federation. Keywords: Fibrin Matrices for Tissue Engneering, Novel Polymer Materials for Biotechnology Applications, Synthetic ECM Analogs, Protein Engineering for Biomaterial Systems. http://lmrp.epfl.ch/

2007-2009 Significant Publications Gapany C, Frey P, Cachat F, Gudinchet F, Jichlinski P, Meyrat BJ, Ramseyer P, Theintz G, Burnand B., “Management of cryptorchidism in children: guidelines”, Swiss Med Wkly (23/08/2008), 138(33-34):492-8 Adelöw C, Segura T, Hubbell JA and Frey P., “The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype”, Biomaterials (2008), 29: 314-326 Gapany C, Grasset N, Tercier S, Ramseyer P, Frey P, Meyrat BJ, “A lower fistula rate in hypospadias surgery”, Journal of pediatric urology (2007), 3(5):395-7 Oberson C, Boubaker A, Ramseyer P, Meyrat BJ, Frey P, “Endoscopic and surgical treatment of vesico-ureteral reflux in children. Comparative long-term follow-up”, Swiss Med Wkly (2007), 137(33-34):471-5 Ramseyer P, Meagher-Villemure K, Burki M, Frey P, “(Poly)acrylonitrile-based hydrogel as a therapeutic bulking agent in urology”, Biomaterials (2007), 28(6):1185-90

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Research Interests Prof. Frey has been working with the EPFL’s School of Life Science’s laboratory for regenerative medicine and pharmacobiology since 2004, concentrating more particularly on tissue engineering of the urinary tract and the development of biomaterials.

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Laboratory of Life Sciences Electronics Carlotta Guiducci, Tenure Track Assistant Professor SwissUp Chair in Engineering 2009: Assistant Professor Tenure Track at the IBI, EPFL. 2007 - 2008: Junior group leader at the University of Bologna, Italy; 2005 - 2007: Postdoc at ESPCI Paris (F). 2005: PhD in Electrical Engineering from the University of Bologna, Italy. 2001: Master Degree in Electrical Engineering, Microelectronics Career from the University of Bologna, Italy. At EPFL since 01/02/2009 Keywords: biosensors, integrated systems, parallel detection and interaction. http://clse.epfl.ch/

2007-2009 Significant Publications Y Temiz, F.K. Gurkaynak, S Terrettaz, H Vogel, G De Micheli, Y Leblebici, C Guiducci, and L Benini, “Real-Time HighSensitivity Impedance Measurement Interface for Tethered BLM Biosensor Arrays", Proceedings of the 7th IEEE Sensors conference (26/10/2008), pages 650-653 C. Guiducci, C. Stagni, M. Brocchi, M. Lanzoni, B. Ricco, A. Nascetti, D. Caputo, and A. De Cesare, “Innovative optoelectronic approaches to biomolecular analysis with arrays of silicon devices", Vlsi-Soc: Research Trends in Vlsi and Systems on Chip (2008), pages 37-53 C. Guiducci, A. Schmid, F. K. Guerkaynak, and Y. Leblebici, "Novel front-end circuit architectures for integrated bioelectronic interfaces", roceedings of Design Automation and Test in Europe (DATE) Conference 2008 (2008), pages 13281333 C. Stagni, C. Guiducci, L. Benini, B. Ricco, S. Carrara, C. Paulus, M. Schienle, and R. Thewes, "A fully electronic label-free DNA sensor chip", Ieee Sensors Journal (2007), volume 7, number 3-4, pages 577-585 L. Benini, C. Paulus, and C. Guiducci, "Electronic detection of DNA hybridization: Toward CMOS microarrays", Ieee Design & Test of Computers (2007), volume 24, number 1, pages 38-48 2007-2009 Patents B. Ricco, C. Guiducci, and L. Benini, "Micro-array device, for DNA recognition, includes micro-sensors to output signals indicating absorption of ultraviolet radiation in micro-location, when traversed by UV beam during hybridization process": PCT/IB2006/000531. Collaborations & Networks Department of Electronics and Department of Biochemistry, University of Bologna (I). LETI, CEA, Grenoble (F).

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Research Interests Current Group Design and characterization of electronic biosensors. Applications span from nucleic acid, protein and drug 2 PhD Students detection to the measurements of bacterial metabolism. 1 Administrative Assistant 2 Internship Students

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Laboratory of Computational Systems Biotechnology Vassily Hatzimanikatis, Associate Professor (SV/SB) Dr. Vassily Hatzimanikatis is currently Associate Professor of Chemical Engineering and Bioengineering at École Polytechnique Fédérale de Lausanne (EPFL). Vassily received a PhD and a MS in Chemical Engineering from the California Institute of Technology, and his Diploma in Chemical Engineering from the University of Patras, in Greece. After the completion of his doctoral studies, he held a research group leader position at the Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland. Prior to joining Northwestern, Vassily worked for three years in DuPont, Cargill, and Cargill Dow, on the development of biocatalysts for the production of industrial chemicals, and for six years as an Assistant Professor of Chemical Engineering at Northwestern University in Evanston, Illinois. Vassily was a DuPont Young Professor (2001-2004) and he received the Jay Bailey Young Investigator Best Paper Award in Metabolic Engineering in 2002. While at Northwestern University he received the Teacher of the Year Award from the School of Engineering and Applied Sciences in 2004. He is currently a member of the Executive Committee of SystemsX, the Swiss Initiative in Systems Biology. Keywords: Modeling and Analysis of Large Biopolymerization Networks, Metabolic Control Analysis under Uncertainty, Discovery of Novel Biotransformations. http://isic2.epfl.ch/page63322-en.html

2007-2009 Significant Publications R. Thomas, C.J. Paredes, S. Mehrotra, V. Hatzimanikatis and E.T. Papoutsakis, “A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression data.", BMC Bioinformatics (2007), 8, 228-239 C.S. Henry, L.J. Broadbelt and V. Hatzimanikatis, “ThermodynamicsBased Metabolic Flux Analysis", Biophysical Journal (2007), 92(5), 1792-1805 H. Zouridis and V. Hatzimanikatis, “A Model for Protein Translation: Polysome Self-Organization Leads to Maximum Protein Synthesis Rates", Biophysical Journal (2007), 92(3), 717-730

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Research Interests Vassilyâ&#x20AC;&#x2122;s research interests are in the areas of systems biotechnology, bioinformatics, and complexity of biological systems. He is associate editor of the journal Biotechnology and Bioengineering, and associate editor for Bioinformatics of the journal Metabolic Engineering. He serves on the editorial advisory board of the journals Bioprocess and Biosystems Engineering and Journal of Chemical Technology & Biotechnology. He has published over 40 technical articles and he is co-inventor in two patents.

Current Group 3 Postdoctoral Fellows 7 PhD Students 1 Administrative Assistant 4 Visiting Students

Teaching Activities Courses Principles and Applications of Systems Biology - Master level course Biotechnology TP - Bachelor level course Introduction to Chemical Engineering - Bachelor level course Master/Semester Projects Redesigning of Yeast Metabolism Tools for Analysis of Genome-scale Metabolic Models Analysis of Signaling Pathways Modeling of Electron Transport Chain of Saccharomyces cerevisiae Modeling and optimization of Jak-Stat pathway Modeling and Analysis of Enzyme Kinetics Search for Missing Pathways in Metabolism Modeling and Analysis of the Sphingolipid Biosynthesis Pathway in Yeast

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Regenerative Medicine and Pharmacobiology Laboratory Jeffrey Hubbell, Full Professor (SV/SB/STI) Director of the Insitute of Bioengineering, Director of the Center for Neuroprosthetics, Merck Serono chair in Drug Delivery EDUCATION B.S. Chemical Engineering, Kansas State University, 1982 Ph.D. Chemical Engineering, Rice University, 1986 EXPERIENCE 2004-Present Professor (Ordinarius)of Biomedical Engineering in the Integrative Biosciences Institute (Faculty of Life Sciences) and the Instite for Chemical Sciences and Technology (Faculty of Basic Sciences); Director, Integrative Biosciences Institute 1997-2003 Professor (Ordinarius) of Biomedical Engineering in the Department of Materials (ETH) and the Faculty of Medicine (University of Zurich); Director, Institute for Biomedical Engineering (ETH and Univ. Zurich) 1995-1997 Professor of Chemical Engineering, California Institute of Technology 1991-1994 Associate Professor of Chemical Engineering, University of Texas Keywords: Biomaterials, drug delivery, tissue engineering, immunotherapeutics. http://lmrp.epfl.ch//

2007-2009 Significant Publications Velluto, D., Demurtas, D. & Hubbell, J.A. , “PEG-b-PPS diblock copolymer aggregates for hydrophobic drug solubilization and release: Cyclosporin A as an example.", Molecular Pharmaceutics (2008), 5, 632-642 Pharmaceutics 5, 632-642 (2008). Rothenfluh, D.A., Bermudez, H., O’Neil, C.P. & Hubbell, J.A. , “Biofunctional polymer nanopartilces for intra-articular targeting and retention in cartilage.", Nature Materials (2008), 7, 248-254 Kraehenbuehl, T.P., Zammaretti, P., Van der Vlies, A.J., Schoenmakers, R.G., Lutolf, M.P., Jaconi, M.E. & Hubbell, J.A. , “Three-dimensional extracellular matrix-directed cardioprogenitor differentiation: Systematic modulation of a synthetic cell-responsive PEG-hydrogel.", Biomaterials (2008), 29, 2757-2766 Jo, Y.S., van der Vlies, A.J., Gantz, J., Antonijevic, S., Demurtas, D., Velluto, D. & Hubbell, J.A. , “RAFT homoand copolymerization of N-acryloyl-morpholine, piperidine, and azocane and their self-assembled structures.", Macromolecules (2008), 41, 1140-1150 Bearinger, J.P., Stone, G., Christian, A.T., Dugan, L., Hiddessen, A.L., Wu, K.J.J., Wu, L., Hamilton, J., Stockton, C. & Hubbell, J.A., “Porphyrin-based photocatalytic lithography.", Langmuir (2008), 24, 5179-5184 Adelöw, C., Segura, T., Hubbell, J.A. & Frey, P., “The effect of enzymatially degradable poly(ethylene glycol) hydrogels on smoorh muscle cell phenotype.", Biomaterials (2008), 29, 314-326 Reddy, S.T., van der Vlies, A.J., Simeoni, E., Angeli, V., Randolph, G.J., O’Neill, C.P., Lee, L.K., Swartz, M.A. & Hubbell, J.A. , " Exploiting lymphatic transport and complement activation in nanoparticle vaccines.", Nature Biotechnology (2007), 25, 1159-1164 Cerritelli, S., Velluto, D. & Hubbell, J.A. , “PEG-SS-PPS: Reduction-sensitive disulfide block copolymer vesicles for intracellular drug delivery.", Biomacromolecules (2007), 8, 1966-1972 Cerritelli, S., Velluto, D. & Hubbell, J.A. , “PEG-SS-PPS: Reduction-sensitive disulfide block copolymer vesicles for intracellular drug delivery.", Biomacromolecules (2007), 8, 1966-1972

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Research Interests Our research is in the field of biomaterials, with applications in tissue engineering and drug delivery in mind. We tend to select research problems that require a substantial understanding of biology and that require the development of novel materials. As such, our group consists of people with backgrounds in biology, materials chemistry, and bioengineering, about one-third coming from each area. Our materials focus at the moment is biological activity, whether the design and use of biological or biomimetic molecules, or the development of materials that can respond to biological signals. Our applications foci at the moment are (i) regenerative medicine, especially angiogenesis, bone healing, chronic dermal wound healing, and nerve regeneration; (ii) delivery of drugs to the cytoplasm or the nucleus, especially delivery of plasmid DNA and antisense oligonucleotides across the plasma membrane and into the appropriate intracellular targets; and (ii) delivery of anticancer or antiproliferative drugs in difficult-to-reach loci using biological trafficking, especially the coronary artery wall and the lymphatics.

Current Group 1 Senior Scientist 1 Adjunct Professor 2 Scientists 9 Postdoctoral Fellows 14 PhD Students 2 MD, PhD Students 1 Administrative Assistant 1 Engineer 1 Technician

Collaborations & Networks The LMRP leads the EU FP7 Large Scale Integrative Project "Angioscaff ", working the area of angiogenesis-inducing biomolecules and biomaterial scaffolds. This Euro 12.5 million project unites 20 academic laboratories and 10 corporate partners working on novel second-generation engineered angiogenesis factors, novel material delivery platforms, and applications in bone, skin, muscle and nerve, as well as with basic investigations into angiogenesis science using these molecular and materials tools. Teaching Activities Introduction to Biochemical Engineering, MS course in Bioengineering and Chemical Engineering. Biomaterials, MS course in Bioengineering and Chemical Engineering (with M.P. Lutolf) Materials Science, BS course in Bioengineering (with H-A Klok). Design Projects in Bioengineering and Biotechnology.

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Laboratory of Protein Engineering Kai Johnsson, Full Professor (SB) Kai Johnsson did his Ph.D. in the lab of Prof. Steven Benner in the Department of Organic Chemistry at the ETH Zürich, working on the design of catalytically active polypeptides. In 1992 he joined the group of Prof. Peter G. Schultz at the University of California, Berkeley as a postdoc, working on the mechanism of action of the tuberculosis drug isoniazid, catalytic antibodies, and the organization of nanoparticles using DNA. After 2 ½ years at the Ruhr-Universität Bochum, Germany, he was appointed in 1999 as an assistant professor at the Chemistry Department of the University of Lausanne and subsequently at the EPFL. Since 2005 he is associate professor at the Institute of Chemical Sciences and Engineering at the EPFL. His current research interests are the development and application of chemical approaches to study and manipulate protein function. Kai Johnsson is Associate Editor of ACS Chemical Biology since 2005. He is member of the editorial board of Chemistry&Biology, member of the advisory board of Chemical Society Reviews and Member of Faculty of 1000. He is co-founder of Covalys Biosciences which is based on protein labeling technologies developed in his laboratory; these technologies are now available through New England BioLabs. He received the Prix APLE for the invention of the year 2003 of the EPFL. Keywords: semisynthetic fluorescent sensor proteins, protein-protein interactions, functional proteomics, drug candidates for tuberculosis, controlling protein function in living cells. http://isic2.epfl.ch/page58098.html

2007-2009 Significant Publications Matthias A. Brun, Kui-Thong Tan, Eiji Nakata, Marlon J. Hinner, and Kai Johnsson, “Semisynthetic fluorescent sensor proteins based on self-labeling protein tags”, J. Am. Chem. Soc. (2009), Kai Johnsson, “Visualizing biochemical activities in living cells”, Nature Chemical Biology (2009), volume 5, pages 63-65 Helen O’Hare, Alexandre Juillerat, Petra Dianiskova, and Kai Johnsson, “A split-protein sensor for studying protein-protein interactions in mycobacteria”, Journal of Microbiological Methods (2008), volume 73, pages 79-84 Johanna Generosi, Michel Kropf, Giorgio Margaritondo, Harald Hirling, Stefan Catsicas, Kai Johnsson, Norman H. Tolk, David W. Piston, and Antonio Cricenti, “AMPA receptor imaging by infrared scanning near-field optical microscopy”, Physica Status Solidi (2008), volume 5, number 8, page 2641–2644 Christopher Chidley, Katarzyna Mosiewicz, and Kai Johnsson, “A designed protein for the specific and covalent heteroconjugation of biomolecules”, Bioconjugate Chemistry (2008), volume 19, pages 1753-1756 Michel Kropf, Guillaume Rey, Liliane Glauser, Karina Kulangara, Kai Johnsson, and Harald Hirling, “Subunit-specific surface mobility of differentially labeled AMPA receptor subunits”, European Journal of Cell Biology (2008), volume 87, pages 763-778 Johanna Generosi, Giorgio Margaritondo, Michel Kropf, Harald Hirling, Stefan Catsicas, Kai Johnsson, Norman H. Tolk, David W. Piston, and Antonio Cricenti, “Photobleaching-free infrared near-field microscopy localizes molecules in neurons”, Journal of Applied Physics (2008), volume 104, page 106102 Helen M. O’Hare, Rosario Durán, Carlos Cerveñansky, Marco Bellinzoni, Anne Marie Wehenkel, Otto Pritsch, Gonzalo Obal, Jens Baumgartner, Jérome Vialaret, Kai Johnsson, and Pedro M. Alzari, “Regulation of glutamate metabolism by protein kinases in mycobacteria”, Molecular Microgiology (2008), Volume 70, pages 1408-1423 Teaching Activities - Biological chemistry I (SCGC) - Biological chemistry II (SCGC) - Chemical biology (SCGC) - Topics in bioorganic chemistry, biochemistry and biophysics - cycle 1 : Modern aspects of bioorganic chemistry

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Research Interests The visualization and characterization of biologically relevant molecules and activities inside living cells continues to transform cell biology into a truly quantitative science. However, despite the spectacular achievements in some areas of cell biology, the majority of cellular processes still operate invisibly. Further progress will therefore depend increasingly on the development of new (fluorescent) sensors and chemical probes to target and characterize these activities. Our research addresses this need by developing and applying chemical approaches to observe and manipulate protein function in living cells. For example, we have introduced general methods for the covalent and specific labeling of fusion proteins with chemically diverse compounds that open up new ways of studying proteins (i.e. SNAP-tag, CLIP-tag and ACP-tag). We are pursuing the further development of such approaches and their application to biological problems that cannot be resolved by traditional approaches.

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Current Group 6 Scientists 1 Laboratory Assistant 3 Postdoctoral Fellows 7 PhD Students 1 Scientific Adviser

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Laboratory of Stem Cell Bioengineering Matthias Lutolf, Tenure Track Assistant Professor Matthias Lutolf completed his undergraduate studies in Materials Engineering at ETH Zurich (1999) with a Masters thesis in the group of Prof. Ulrich W. Suter. From 1996 to 1997 he worked as trainee for ABB (Baden-Daettwil), Sulzer Innotec (Winterthur), Contraves Space (Zurich) and Baxter Healthcare Corporation (Irvine, USA). He carried out his graduate studies at ETH and the University of Zurich in the group of Prof. Jeffrey A. Hubbell. In 2005, Lutolf joined the Baxter Laboratory in Genetic Pharmacology of Prof. Helen Blau at Stanford University School of Medicine. He was awarded a Leukemia and Lymphoma Society fellowship (2006) for his research on microenvironmental regulation of hematopoietic stem cells. Since February 2007 he is Assistant Professor within the Faculty of Life Sciences and Institute of Bioengineering at the EPFL. His current research activities interface biomolecular engineering with adult stem cell biology. Lutolf recently won a prestigious European Young Investigator (EURYI) award to start up his independent research at EFPL. At EPFL since 01/03/2007 Keywords: Stem cell bioengineering, tissue engineering, biomolecular materials. http://lscb.epfl.ch/

2007-2009 Significant Publications Lutolf, M.P.* and Blau, H.M.*, “Artificial stem cell niches”, Advanced Materials (2009), DOI: 10.1002/adma.200802582 Lutolf, M.P.,, “Biomaterials: Spotlight on hydrogels”, Nature Materials (2009), 8, 451 - 453 Kobel, S., Limacher, M., Gobaa, S., Laroche, T., Lutolf, M.P.*, “Micropatterning of hydrogels by soft embossing”, Langmuir (2009), DOI: 10.1021/la9002115 Lutolf, M.P.*, “Artificial ECM: expanding the cell biology toolbox in 3D”, Integrative Biology (2009), 1, 235 - 241 Lutolf, M.P.*, Doyonnas, R., Havenstrite, K., Koleckar, K., Blau, H.M.*, “Perturbation of single hematopoietic stem cell fates in artificial niches”, Integrative Biology (2009), 1, 59 Jo Y.S., Gantz, F., Hubbell, J.A., Lutolf, M.P.*, “Tailoring hydrogel degradation and drug release via neighboring amino acidcontrolled ester hydrolysis”, Soft Matter (2009), 5, 440-446 Cordey, M., Limacher, M., Kobel, S., Taylor, V., Lutolf, M.P.*, “Enhancing the reliability and throughput of neurosphere culture on hydrogel microwell arrays”, Stem Cells (2008), 26, 2586-2594 Ehrbar, M., Rizzi, S.C., Schoenmakers, R., Hubbell, J.A., Weber, F.E., Lutolf, M.P.*, “Biomolecular hydrogels formed and degraded via site-specific enzymatic reactions”, Biomacromolecules (2007), 8(10) : 3000-3007 Ehrbar, M., Rizzi, S.C., Schoenmakers, R., Zisch, A.H., Hubbell, J.A., Weber, F.E., and Lutolf, M.P.*, “Enzymatic formation of modular cell-instructive synthetic fibrin analogs for tissue engineering”, Biomaterials (2007), 28(26): 3856-66 2007-2009 Awards European Young Investigator (EURYI) Award, European Science Foundation 2007-06-01 Jean Leray Award for Excellence in biomaterials research, European Society for Biomaterials 2008-05-01

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Research Interests Research in the Lutolf is at the interface of stem cell biology and biomolecular engineering to gain fundamental insight into how protein components of tissue-specific microenvironments, termed niches, control the behavior of multipotent adult stem cells such as hematopoietic stem cells (i.e. the stem cells that give rise to all blood cells).

Current Group 3 Postdoctoral Fellows 6 PhD Students 1 Administrative Assistant

We develop novel technologies to biochemically and structurally deconstruct in vivo niches, and reconstruct them in vitro, creating well-defined artificial stem cell niches as novel paradigms to decipher adult stem cell regulation. We are using these platforms as tools to probe the biochemical stem cell-niche crosstalk at the single cell level and in high-throughput. This research will yield insights into the dynamics of stem cell fate changes in response to extrinsic protein signals, and may spawn new strategies for tissue engineering and stem cell-based therapies, for example the robust expansion of rare hematopoietic stem cells for the treatment of blood cancers.

2007-2009 External Grants received at the EPFL SystemsX.ch IPP (with J. Brugger, EPFL) 2009

CHF 20’000

Swiss National Science Foundation 3 2009-2012

CHF 180’000

Swiss National Science Foundation 2 2009-2012

CHF 360’000

Swiss National Science Foundation 1 2007-2009

CHF 210’000

Novartis Consumer Health Foundation 2009-2010

CHF 70’000

Marie Curie Intra-European Fellowships (IEF) 2009-2011

CHF 244’000

KTI 2007-2009

CHF 240’000

EURYI Award 2007-2012 EU FP7 (Angioscaff) 2009-2012

CHF 2’000’000 CHF 380’000

Collaborations & Networks Many national and international collaborators Teaching Activities Biomaterials [en] (SMX SPH SSV SCGC) Stem Cells [en] (SSV SSIE SCGC)

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Laboratory of Biological Network Characterisation Sebastian Maerkl, Tenure Track Assistant Professor Prof. Maerkl received two bachelor degrees in biology and chemistry from Fairleigh-Dickinson University in 2001. Maerkl then joined Caltech where he pursued his PhD in the laboratory of Prof. Quake. During his PhD, Maerkl implemented the first highly-integrated microfluidic device. He later applied this technology to systems biology. His PhD research resulted in two Science, a Nature Biotechnology, and a Nature Method publication. Maerkl achieved 1st place in the I-Challenge in 2005, a joint technology contest between Stanford, UC Berkeley, and Caltech. He was also awarded the DTK prize, which honors annually the best Caltech PhD thesis in Biotechnology. Sebastian Maerkl joined EPFL in 2008 where he established a rapidly expanding group. Sebastian Maerkl is currently the lead PI of the SystemsX.ch RTD DynamiX, which brings together 5 PIs to work on yeast systems biology, as well as a Nano-Tera NTF. At EPFL since 15/01/2008 Keywords: microfluidics, systems biology, transcription factor biophysics. http://lbnc.epfl.ch/

2007-2009 Significant Publications Maerkl S.J. and Quake S.R., “Experimental determination of the evolvability of a transcription factor”, PNAS (Accepted), Einav, S., D. Gerber, P.D. Bryson, E.H. Sklan, M. Elazar, S.J. Maerkl, J.S. Glenn, and S.R. Quake, “Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.”, Nature Biotechnology (31/08/2008), 1019-1027 Huang, L., S.J. Maerkl, and O.J. Martin, “Integration of plasmonic trapping in a microfluidic environment.”, Optics Express (30/03/2009), 6018-6024 Thorsen, T., S.J. Maerkl, and S.R. Quake, “Microfluidic large-scale integration.”, Science (18/10/2002), 580-584 Maerkl, S.J. and S.R. Quake, “A systems approach to measuring the binding energy landscapes of transcription factors.”, Science (12/01/2007), 233-237 Maerkl, S, “Microfluidic high-throughput screening”, Integrative Biology (01/01/2009), 19-29 2007-2009 Awards 1st Place, I-Challenge 2005-01-06 The I-Challenge is a joint technology contest amongst Stanford University, UC Berkeley, and the California Institute of Technology. Demetriades-Tsafka-Kokkalis Prize, Caltech 2008-05-23 For the best Caltech PhD thesis in the field of Biotechnology. 2007-2009 Patents Maerkl S.J. and Quake S.R., “Mechanically Induced Trapping of Molecular Interactions”: 60/762,300 Maerkl S.J. and Quake S.R., “Programming Microﬂuidic Devices with Molecular Information”: 60/762,344

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Research Interests The Maerkl lab conducts research at the interface of engineering and biology. We are interested in developing novel, state-of-the-art microfluidic technology to solve pertinent problems in systems biology, Darwinian evolution, and synthetic biology/genetic engineering. We are currently developing methods to understand protein expression dynamics on a proteome wide scale with high-spatio temporal resolution. We are also establishing quantitative models of eukaryotic transcriptional regulation by synthesizing hundreds of promoter constructs and measuring the characteristic induction curves of these promoters. Finally, we are developing a rapid approach to generating proteome scale protein arrays to map the interaction networks of transcription factors. The lab is also developing methods in the fields of Darwinian molecular evolution, in vitro synthetic biology, and we are continuing our research on understanding transcription factor biophysics in the context of gene regulation and evolution. In the field of microfluidics we are developing software programmable microfluidic devices.

2007-2009 External Grants received at the EPFL SystemsX.ch RTD 2008-2012 SystemsX.CH IPP 2010-2011 Nikon 2009

CHF 2’296’000 CHF 119’558 CHF 7’500

Nano-Tera 2008-2009

CHF 85’190

KGF 2009

CHF 12’500

FP7 2010-2013

Current Group 5 PhD Students 2 Postdoctoral Fellows 3 PhD Students (external) 1 Undergraduate Student 1 Internship Student 1 Administrative Assistant

CHF 352’315

Collaborations & Networks John McKinney (SV) Olivier Martin (STI) Bart Deplancke (SV) Matthias Lutolf (SV) Felix Naef (SV) Michael Unser (STI) David Shore (U. Geneva) Martin Kreitman (U. Chicago) Michael Laessig (U. Cologne) Teaching Activities 2008 iGEM project course 2009 iGEM project course Together with Prof. Deplancke, Maerkl is teaching the iGEM project course. iGEM is an annual competition held at MIT. The iGEM project course is year-long and involves lecture series, brain storming sessions, and active lab work. In 2009 Deplancke and Maerkl raised 40’000 CHF of support.

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Defitech Chair in Non-Invasive Brain-Machine Interface José del Rocio Millán Ruiz, Associate Professor Chair of EPFL Center for Neuroprosthetics José del R. Millán is the Defitech Professor at EPFL. He received his Ph.D. in computer science from the Univ. Politècnica de Catalunya (Barcelona, Spain) in 1992, where he was an assistant professor for three years. He was also a research scientist at the Joint Research Centre of the European Commission in Ispra (Italy), a senior researcher at the Idiap Research Institute in Martigny (Switzerland), and a visiting scholar at the Universities of Stanford and Berkeley. Dr. Millán is a pioneer in the fields of adaptive intelligent robotics and brain-computer interfaces (BCI). He designed one of the first reinforcement-learning adaptive robots in the early 90s. In 1996, he started to work on non-invasive BCI and since has led 3 European projects on this field. His research on BCI was nominated finalist of the European Descartes Prize 2001 and he was named Research Leader 2004 by the journal Scientific American for his work on brain-controlled robots. The journal Science has reviewed his work as one of the world’s key researchers in the field of BCI. Dr. Millán is a frequent keynote speaker at international events as well as an IEEE Distinguished Lecturer. His work on BCI has received wide media coverage around the world. At EPFL since 15/10/2008 Keywords: neuroprosthetics, brain-machine interfaces, machine learning, robotics, neuroscience. http://cnbi.epfl.ch

2007-2009 Significant Publications Garipelli, G., Chavarriaga, R., and Millán, J. del R., “Fast Recognition of Anticipation Related Potentials”, IEEE Trans. on Biomedical Engineering (2009), vol. 56, pp. 1257–1260 Millán, J. del R., Ferrez, P.W., and Seidl, T., “Validation of Brain-Machine Interfaces during Parabolic Flight”, International Review of Neurobiology (2009), vol. 86, to appear. Special issue on “Brain Machine Interfaces for Space Applications: Enhancing Astronaut Capabilities” Ferrez, P.W. and Millán, J. del R., “Error-Related EEG Potentials Generated during Simulated Brain-Computer Interaction”, IEEE Trans. on Biomedical Engineering (2008), vol. 55, pp. 923-929 Millán, J. del R., Ferrez, P.W., Galán, F., Lew, E., and Chavarriaga, R., “Non-Invasive Brain-Machine Interaction”, International Journal of Pattern Recognition and Artificial Intelligence (2008), vol. 22, pp. 959-972 Bourdaud, N., Chavarriaga, R., Galán, F., and Millán, J. del R., “Characterizing the EEG Correlates of Exploratory Behavior”, IEEE Trans. on Neural Systems and Rehabilitation Engineering (2008), vol. 16, pp. 549–556 Galán, F., Nuttin, M., Lew, E., Ferrez, P.W., Vanacker, G., Philips, J., and Millán, J. del R., “A Brain-Actuated Wheelchair: Asynchronous and Non-Invasive Brain-Computer Interfaces for Continuous Control of Robots”, Clinical Neurophysiology (2008), vol. 119, pp. 2159–2169 Millán, J. del R., “Brain-Controlled Robots”, IEEE Intelligent Systems (2008), vol. 23, pp. 74–76 Marcel, S. and Millán, J. del R., “Person Authentication using Brainwaves (EEG) and Maximum A Posteriori Model Adaptation”, IEEE Trans. on Pattern Analysis and Machine Intelligence (2007), vol. 29, pp. 743-748

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Research Interests Dr. Millán explores the use of brain signals for multimodal interaction and, in particular, the development of non-invasive brain-controlled robots and neuroprostheses. In this multidisciplinary research effort, he is bringing together his pioneering work on the two fields of brain-computer interfaces (BCI) and adaptive intelligent robotics. Among his achievements, Dr. Millán and his students have developed the first noninvasive brain-controlled mobile robot and wheelchair.

Current Group 9 PhD Students 2 Master Students 1 Postdoctoral Fellow 1 Scientist 1 Administrative Assistant

The primary focus of his research on BCI is to augment the capabilities of paralyzed people by providing a new interaction link with the outside world that they can operate naturally without requiring any kind of external stimulation. His algorithms for real-time analysis of brain activity allow users to convey mental commands very rapidly, on the order of hundred of milliseconds. In addition, he designs approaches to monitor users’ cognitive state in order to facilitate interaction. Dr. Millán has recently run, in collaboration with the European Space Agency during the December07’s parabolic flight campaign, the first experiments of BCI operated in microgravity conditions. The long-term goal of this project is develop BCI to compensate some of the limits imposed to human sensory-motor system by zero-gravity environments.

2007-2009 Awards IEEE SMC Distinguished Lecturer, IEEE 2009-05-27 2007-2009 External Grants received at the EPFL Swiss NSF 2009-2012

CHF 318’000

European Commission 2008-2012 managed)

CHF ~3’000’000 (~14,000’000 total

European Commission 2009-2012

CHF ~500’000

European Commission 2006-2010

CHF ~950’000

Collaborations & Networks Formal collaborations (mainly through European projects) with: - BCI groups (notably, Fondazione Santa Lucia in Rome, Technical Univ. Graz, Technical Univ. Berlin, Univ. Tuebingen). - Neuroprosthetics and neurorehabilation clinics (e.g., Univ. Heidelberg, Fondazione Santa Lucia, Suva in Sion). - Robotics groups (e.g., ETHZ, Katholeike Univ. Leuven, Grenoble). - European Space Agency. Teaching Activities “Brain-computer Interaction”

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Biomechanical Orthopedics Laboratory Dominique Pioletti, Tenure Track Assistant Professor Assistant Professor of the Interinstitutional Center of Translational Biomechanics Prof. Dominique Pioletti received his Master in Physics from the EPFL in 1992. He pursued his education in the same Institution and obtained his PhD in biomechanics in 1997. He developed original constitutive laws taking into account viscoelasticity in large deformations. Then he spent two years at UCSD as post-doc fellow acquiring know-how in cell and molecular biology. He was interested in particular to gene expression of bone cells in contact to orthopedic implant. Since April 2006, Dominique Pioletti is appointed Assistant Professor tenure-track at the EPFL and is director of the Laboratory of Biomechanical Orthopedics. Keywords: Biomechanics, issue Engineering, Mechano-biology. http://lbo.epfl.ch/

2007-2009 Significant Publications Blecha L.D., Rakotomanana L., Razafimahery F., Terrier A., Pioletti D.P. , “Targeted mechanical properties for optimal fluid motion inside artificial bone constructs.”, J Orthop Res (2009), 10821089 Stadelmann V.A., Terrier A., Gauthier O., Bouler J.-M., Pioletti D.P., “Prediction of bone density around orthopedic implants delivering bisphosphonate.”, J. Biomechanics (2009), 1206-1211 Terrier A., Merlini F., Pioletti D.P., Farron A, “Total shoulder arthroplasty: downward inclination of the glenoid component to balance supraspinatus deficiency.” , J Shoulder Elbow Surg, (2009), 360-365 Terrier A., Merlini F., Pioletti D.P., Farron A., “Comparison of polyethylene wear in anatomic and reversed shoulder prostheses.”, J Bone Joint Surg-B (2009), 977-982 Montjovent M.O, Mark S, Mathieu L., Scaletta C., Scherberich A., Delabarde C., Zam-belli P.Y., Bourban P.E., Applegate L.A., Pioletti D.P. , “Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering.”, Bone (2008), 554-564 Stadelmann V.A., Gauthier O., Terrier A., Bouler J-M., Pioletti D.P. , “Implants delivering bisphosphonate locally increase peri-implant bone density in an osteoporotic sheep model.”, Eur Cell Mat (2008), 10-16 Stadelmann V.A., Terrier A., Pioletti D.P. , “Microstimulations at the bone implant interface upregulate osteoclast activation pathway.”, Bone (2008), 358-364 Ramaniraka N.A., Saunier P., Siegrist O., Pioletti D.P. , “Biomechanical evaluation of intraarticular and extra-articular procedures in ACL reconstruction: a finite element analysis.”, Clinical Biomechanics (2007), 336-343 2007-2009 Awards Advanced Researcher, Société de Biomécanique 2007-2009 Patents Bourban, Buehler, Manson, Mathieu, Pioletti, Stadelmann, “Cellular gradient polymer composites”: 0013-066.B.WO

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Research Interests The LBO focus its research on the orthopedic field developing new solutions based on engineering or biological approaches. In particular, through the understanding of fundamental aspects of mechano-transduction, innovative solutions are proposed to control the tissue formation around implants. A mixed theoretical and experimental approach is followed in the development of orthopedic implant used as drug delivery system, in the incorporation of biomechanical principles to favor bone formation inside artificial scaffold or in the design of new orthopedic implant for shoulder, hip or knee joints. A strong emphasis is put to translate the results obtained in the laboratory to clinical applications by a close collaboration with surgeons of the CHUV and industrial partners.

2007-2009 External Grants received at the EPFL Stryker 2007 Stryker 2007 SNSF 2008-2010 SNSF 2009-2012 SNSF 2009-2012 Fondation Fernando et Rose Inverni-Desarzens 2008-2009 CCMX 2007-2008

Current Group 1 Postdoctoral Fellow 6 PhD Students 1 Administrative Assistant 3 Scientists 1 Laboratory Assistant 1 Group Leader 4 Master Students 4 Undergraduate Students 3 MDs 1 MD, Professor

Collaborations & Networks CHF 43’315 National - LTC, EPFL (Prof. J.A. Månson) CHF 58’982 - LA, EPFL (Prof. R. Longchamp) - LMAM, EPFL (Prof. K. Aminian) CHF 235’555 - Division des maladies osseuses, Université de Genève (Prof. S. Ferrari, Dr. J. Caverzasio) CHF 171’775 - Inselspital, Bern (Dr. R. Nyffeler) - Robert Mathys Foundation, Bettlach (Dr. M. Bohner) CHF 168’775 - Tissue Engineering, University of Basel (Dr. I. Martin) - AO Reseach Institute, Davos (Prof. K. Ito) - Tierspital, Zurich (Prof. B. von Rechenberg) CHF 85’000 - Nonmetallic Inorganic Materials, ETHZ (Dr. U. Gonzenbach) CHF 41’000 International - IRMAR, University of Rennes I, France (Prof. L. Rakotomanana) - INSERM, University of Nantes, France (Prof. J.M. Bouler) - University of Nijmegen, The Netherlands (Prof. N. Verdonschot) - Orthopaedic Mechanobiology Laboratory, University of Maryland (Prof. A. Hsieh) - Cell and Molecular Biomechanics Laboratory, Stanford University (Prof. C. Jacobs) - Cartilage Tissue Engineering Lab, UCSD (Prof B. Sah) Steering committee member - ESF Research Networking Program on regenerative medicine (REMEDIC) 2008-2010. Editorial boards - Member of the Editorial Board for Journal of Biomechanics, since 2009 - Member of the Editorial Board for Applied Bionics and Biomechanics, since 2007 - Member of the Editorial Board for Computer Methods in Biomechanics and Biomedical Engineering, since 2005 - Member of the Editorial Board for Journal of Bone and Joint SurgeryBr, 2003-2005

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Laboratory of Nanoscale Biology Aleksandra Radenovic, Tenure Track Assistant Professor 2008 Tenure-Track Assistant Professor of Bioengineering at the School of Engineering, EPFL 2007 - July 2008 Visiting Scientist NIDCR at NIH Institute Bethesda and HHMI Janelia Farm USA 2004 - 2007 Postdoctoral Fellow Department of Physics, University of California Berkeley,USA December, 2003 PhD in Physics Laboratory of Physics of Living Matter, University of Lausanne December, 1999 Diploma in Physics Department of Physics, Faculty of Science, University of Zagreb At EPFL since 01/08/2000 Keywords: solid-state nanopores, single molecule, GPCRs, RNAP, DNA sequencing, nanoelectrodes. http://lben.epfl.ch/

2007-2009 Significant Publications J. Miklossy, H.Qing, A. Radenovic, A.Kis, B. Villeno, F. Laszlo,L. Miller, R. Martins, G. Waeberf V.Mooser, F. Bosman, K Khalilii, N Darbinian-Sarkissian P. L. McGeer, “Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes”, Neurobiology of Aging (23/10/2008), 2009 in press Y. Nakayama*, P. J. Pauzauskie*, A. Radenovic*, R. M. Onorato, R. J. Saykally, J. T. Liphardt, and P. Yang, “Tunable Nanowire Nonlinear Optical Probe ”, Nature (19/07/2007), 447 (7148): 1098- 1101 (2007) E.Trepagnier* A. Radenovic*, David Sivak, Phillip Geissler and J. Liphardt, “Controlling DNA Capture and Propagation through Artificial Nanopores ”, Nano Letters (17/09/2007), 7 (9), 2824 -2830, (2007) A.Radenovic, E.Trepagnier, R. Csencsits, K. Downing and J. Liphardt, “ Fabrication of 10 nm diameter hydrocarbon nanopore ”, Applied Physics Letters (15/06/2008), 93, 183101 (2008) 2007-2009 Patents Pauzauskie P, Radenovic A, Trepagnier E, Liphardt J, Yang P , “Alignment, Transportation And Integration Of Nanowires Using Optical Trapping”: WO2007079411-A2; WO2007079411-A3; US2008315175-A1

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Research Interests The research of the Laboratory of Nanoscale Biology focuses on developing tools and probes for single molecule biophysics. The group uses optical tweezers, AFM, single-molecule fluorescence, and nanofabricated structures to study biomolecular systems and advance new nanotechnology.

Current Group 2 PhD Students 2 Postdoctoral Fellows 1 Student Assistant

Current experimental work in our lab focuses on two interconnecting areas: 1.Nanofabricated probes and platforms for single-molecule biophysics experiments Including nanofabricated SHG nanocylinders, solid-state nanopores, local nanolectrodes for molecular sensing and sequencing 2. Local probe studies of single biomolecules For example RNA polymerase, DNA binding proteins, membrane proteins such G protein–coupled receptors

2007-2009 External Grants received at the EPFL SystemsX IPhD 2008-2011

CHF 171’725

SNSF 2009-2012

CHF 231’536

FP7-NMP-2007-SMALL-1 2009-2012

CHF 80’000

Collaborations & Networks Catherine G. Galbraith, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892 James A. Galbraith, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892Luca Scorrano University of Geneva, Facullty of Medicine Ivo F. Sbalzarini ETH Zurich Institute of Computational Science Teaching Activities Methods in Single Molecule Biophysics Spring Semester 2009 3 credits Mentor for one project in Design Projects in Bioengineering and Biotechnology , Spring 2009

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Hemodynamics and Cardiovascular Technology Laboratory Nikolaos Stergiopulos, Full Professor Director of Doctoral Program in Biotechnology and Biomedical Engineering Nikos Stergiopulos received B.S. in Mechanical Engineering from the National Technilcal University of Athens, Greece in 1985 and M.S. and Ph.D. in Biomedical Engineering from Iowa State University, USA in 1987 and 1990, respectively. In 1991 moves to the EPFL as a Scientific Collaborator, to be later promoted to Assistant Professor in 1996 and Associate Professor in 2003. He is director of the Laboratory of Hemodynamics and Cardiovascular Technology. His main research interests are arterial wall mechanics, arterial wall remodeling, hemodynamics, heart-arterial system interaction and vascular implants. He currently directs the Graduate Program of Bioengineering. Nikos Stergiopulos has been actively promoting technology transfer and entrepreneurship in Medical Device Technology. In 1998 he co-founded EndoArt, a medical device company, world leader in telemetrically controlled implants for the treatment of congenital heart disease and morbid obesity. In 2008 he has founded Antlia S.A., a medical device startup developing implantable drug delivery pumps for the preclinical and clinical markets. Keywords: Vascular mechanics, hemodynamics, medical devices. http://lhtc.epfl.ch/

2007-2009 Significant Publications Fonck E, Feigl GG, Fasel J, Sage D, Unser M, Rufenacht DA, and Stergiopulos N, “Effect of Aging on Elastin Functionality in Human Cerebral Arteries”, Stroke (2009), Ioannou CV, Morel DR, Katsamouris AN, Katranitsa S, Startchik I, Kalangos A, Westerhof N, and Stergiopulos N, “Left Ventricular Hypertrophy Induced by Reduced Aortic Compliance”, J Vasc Res (2009), 46: 417-425 Tsamis A and Stergiopulos N, “Arterial remodeling in response to increased blood flow using a constituent-based model”, J Biomech (2009), 42: 531-536 Gambillara V, Thacher T, Silacci P, and Stergiopulos N, “Effects of reduced cyclic stretch on vascular smooth muscle cell function of pig carotids perfused ex vivo”, Am J Hypertens (2008), 21: 425-431 Roy S, Tsamis A, Prod’hom G, and Stergiopulos N, “On the in-series and in-parallel contribution of elastin assessed by a structure-based biomechanical model of the arterial wall”, J Biomech (2008), 41: 737-743 Fonck E, Prod’hom G, Roy S, Augsburger L, Rufenacht DA, and Stergiopulos N, “Effect of elastin degradation on carotid wall mechanics as assessed by a constituent-based biomechanical model”, Am J Physiol Heart Circ Physiol (2007), 292: H2754-2763 Tsamis A and Stergiopulos N., “Arterial remodeling in response to hypertension using a constituent-based model”, Am J Physiol Heart Circ Physiol (2007), 293: H3130-3139 Zulliger MA and Stergiopulos N, “Structural strain energy function applied to the ageing of the human aorta”, J Biomech (2007), 40: 3061-3069

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Research Interests Understanding the way blood flow and the related physical forces (pressure, tension, wall shear) interact with the heart and vascular tissue is one of the key elements in understanding the genesis, progression, diagnosis and treatment of cardiovascular disease. Current lines of research are: - Arterial wall biomechanics and vascular remodeling - Blood flow in the cerebral circulation - Wave propagation in the systemic circulation - Ventricular-arterial coupling in ageing and hypertension - Effect of hemodynamical forces on the endothelium and vascular smooth muscle

Current Group 3 Postdoctoral Fellows 1 Senior Scientist 2 Engineers 5 PhD Students 4 Master Students

Teaching Activities - Fluid mechanics for life scientists (BS level, 4 credits) - Cardiovascular Mechanics (MS level, 3 credits) - Selected chapters in Medical Technology (MS level, 3 credits) - Integrative biomechanics (MS level, 2 credits)

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Laboratory of Lymphatic and Cancer Bioengineering Melody Swartz, Associate Professor (SV/SB) Melody Swartz is an Associate Professor of Bioengineering (SV and STI) and has joint appointments in ISIC at the École Polytechnique Fédédrale de Lausanne. She received her BS in Chemical Engineering from Johns Hopkins University in 1991, and her PhD in Chemical Engineering from MIT in 1998. She did a postdoc at Harvard in the group of Dr. Jeffrey Drazen of the Brigham & Women’s Hospital. In 1999, she moved to Northwestern University as an Assistant Professor of Biomedical Engineering, and after 3.5 years, she was recruited to the EPFL. Throughout her career, she has focused on the lymphatic system, integrating physiology, bioengineering, tissue mechanics, and cell biology to elucidate their functional-biological regulation and more recently how immune cells and cancer cells gain access to the lymphatics. Keywords: Lymphatic biology, cancer metastasis, biotransport, biomechanics, tissue engineering, cell engineering, lymphangiogenesis, lymph node, immunomodulation. http://lmbm.epfl.ch/

2007-2009 Significant Publications AA Tomei, S Siegert, MR Britschgi, SA Luther, and MA Swartz, “Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node model”, Journal of Immunology (2009), in press JB Dixon, S Rangunathan, and MA Swartz, “A tissue engineered model of the intestinal microenvironment for evaluating lipid uptake into lacteals”, Biotechnology and Bioengineering (2009), 103(6): 1224-35 A Issa, TX Le, AN Shoushtari, JD Shields, and MA Swartz, “VEGF-C and CCL21 in tumor celllymphatic crosstalk promote invasive phenotype”, Cancer Research (2009), 69:349-57 JA Hubbell, SN Thomas, and MA Swartz, “Materials engineering for immunomodulation”, Nature (2009), 2009 MA Swartz, JA Hubbell, and ST Reddy, “Lymphatic drainage function and its immunological implications: From dendritic cell homing to vaccine design”, Seminars in Immunology (2008), 20(2): 147-56 ST Reddy, AJ van der Vlies, E Simeoni, V. Angeli, GJ Randolph, MA Swartz, and JA Hubbell , “Exploiting lymphatic transport and complement activation in nanoparticle vaccines (won KPMG Innovation award)”, Nature Biotechnology (2007), 25(10): 1159-64 JD Shields, ME Fleury, C Yong, AA Tomei, GJ Randolph, and MA Swartz , “Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling (comment J Cell Biol 178:4; won Servier Award by the Microcirculatory Society in 2008)”, Cancer Cell (2007), 11: 526-538 J Goldman, JM Rutkowski, JD Shields, MC Pasquier, Y Cui, HG Schmoekel, S Wiley, DJ Hicklin, B Pytowski, and MA Swartz, “Cooperative and redundant roles of VEGFR-3 and VEGFR-2 signaling in adult lymphangiogenesis”, FASEB Journal (2007), 21(4):1003-12 2007-2009 Patents JA Hubbell, MA Swartz, ST Reddy, and AJ Van der Vlies, “Immunofunctional Nanoparticles”: U.S. No. 11/707,627

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Research Interests Cancer metastasis, lymphedema, lipid transport, and immune cell function all depend on lymphatic function or dysfunction, and are all tied to interstitial fluid balance and transport. Despite its importance, the regulatory biology of lymphatic function is poorly understood. Furthermore, lymphatic drug delivery holds great potential because of localized targeting of lymph nodes, where one might target metastasized cancer cells, deliver imaging agents, or deliver immunomodulatory drugs to lymph node-resident antigen presenting cells. Our lab aims to elucidate and exploit the integrated physiology and biology of interstitial and lymphatic transport – how it is actively regulated by cells, how it affects cancer metastasis and immune cell trafficking, and how it can be exploited for drug delivery – using interdisciplinary in vivo, in vitro, and in silico approaches. In doing so, we aim to both describe new fundamental mechanisms of lymphatic and interstitial flow mechanobiology and develop new design principles for tissue engineering, immunomodulatory therapeutics, and drug delivery.

Current Group 6 PhD Students 2 Student Assistants 3 Technicians 5 Master Students 2 Erasmus students 1 Administrative Assistant 6 Postdoctoral Fellows 2 Undergraduate Students 1 PhD Student (external)

2007-2009 Awards - Elected Fellow, American Institute for Medical and Biological Engineering (AIMBE) 2007-00-00 - KPMG Innovation Award , KPMG 2007-00-00 with Sai Reddy and Jeffrey Hubbell, for new vaccine technology targeting lymphatics - Best review paper, Annals of Biomedical Engineering 2007-01-01 Pedersen and Swartz, “Mechanobiology in the third dimension", for most downloads in 2006-7 - Highest Cited Original Research, J Controlled Release 2008-01-01 For Reddy et al; most highly cited paper of 2006

Collaborations & Networks 2007-2009 External Grants received at the EPFL Collaborators: US Department of Defense Breast Cancer Research Program 2009-10 CHF 82’000 EPFL: Jeffrey Hubbell, John McKinney Swiss Vaccine Research Institute (with Stefan Kunz and Jeffrey Hubbell, co-PIs) 2009-11 CHF 150’000 University of Lausanne: Sanjiv Luther Swiss National Science Foundation 2008-11

CHF 479’000 Mt. Sinai, New York: Gwendalyn Randolph (joint RO1 from the NIH)

Swiss National Science Foundation 2005-8

CHF 425’000 Texas A&M: David Zawieja

Swiss Cancer League (OncoSuisse) 2008-11

CHF 311’100 University of Bergen, Norway: Helge Wiig

Susan G. Komen Foundation 2008-10

CHF 165’000 Politechnico di Milano: Federica Boschetti; University of Varese: Daniela Negrini CHF 50’000 University of Cape Town: Mladen Poluta, Willem Hanekom CHF 440’000 Networks: NCCR in Molecular Oncology; FP7 AngioScaff CHF 813’900

Novartis Foundation 2007-8 National Institutes of Health / NHLBI 2009-13 Merck-Serono 2009-12 European Research Council 2008-13 European Framework Project 7 (FP7-NMP-2007-LARGE) 2008-12 Competence Center in Materials Science (CCMX), ETH 2006-9 Carigest 2008-11 Bill and Melinda Gates Foundation (Grand Challenges Explorations) 2009-10

CHF 2’600’000 Teaching Activities Biological and physiological transport, Bioingénierie et Biotechnologie master; CHF 587’000 Advanced transport phenomena, Génie chimique et biochimique, Master, Bioingénierie et Biotechnologie - master, Mass and energy balances for engineers, Sciences et technologies du CHF 300’000 vivant, 2009-2010, Bachelor Responsible Conduct in Biomedical Research, École Doctorale de CHF 240’000 Bioingénierie et Biotechnologie (PhD) CHF 110’000

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Group van den Bergh Hubert van den Bergh, Full Professor (SB/ISIC) President of CPA (Committee of professorial promotion) Prof. H. van den Bergh was born in 1943 in New York. He obtained his BA at Williams College, Massachusetts, his MSc at the University of California and his PhD at the University of Cambridge (UK) in physical chemistry. He worked from 1970 to 1973 at the Max Planck Institute in Göttingen (D). In 1973, he joined the Swiss Federal Institute of Technology in the chemistry department. He was nominated professor in 1990 as director of the Laboratory of Atmospheric Pollution and Climate Studies. After basic research in the area of chemical kinetics and collisional energy transfer, he studied laser isotope separation, laser and ion beam induced metallisation of integrated circuits, detection of early cancer by fluorescence endoscopy, photodynamic therapy of cancer and age related macular degeneration, and various aspect of air pollution. For the latter, he developed a number of LIDAR detection systems, mesoscale models and studied reactions on substitute aerosol surfaces. He is the author of about 250 peer reviewed publications and 17 patents. He was awarded the prize of the Swiss Chemical Society in 1978, the Ruzicka prize in 1986, the prize of the Swiss Society of Biomedical Optics in 1989 and the prize of the ILRC in 2000. He is also a member of the executive council of the Swiss National Science Foundation, and consultant for a number of biomedical companies, as well as a member of several editorial boards. Moved from ENAC to STI in Sept. 2008. Keywords: Photodynamic Therapy, Cancer Photodetection, Endoscopic Fluorescence Imaging. http://lpas.epfl.ch/PDT/ Research Interests Detection of early cancer by fluorescence endoscopy, photodynamic therapy of cancer and age related macular degeneration.

2007-2009 Significant Publications Y Hua, S. Lopes, Th. Krueger, L. Decosterd, J.-P. Ballini, H.-B. Ris, S. Andrejevic-Blant, “Comparison of LiposomalEncapsulated vs Free Doxorubicin for Isolated Cytostatic Lung Perfusion in Tumor-bearing Rodents”, (submitted), P. Uehlinger, T. Gabrecht, Th. Glanzmann, J.-P. Ballini, A. Radu, S. Andrejevic, Ph. Monnier, and G. Wagnières , “In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence”, J. Biomedical Optics (2009), pp 1-9 N. Dögnitz, D. Salomon, M. Zellweger, J-.P. Ballini, T. Gabrecht, N. Lange, H. van den Bergh, G. Wagnières, “Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma”, J. Photochem. Photobiol. B: Biol (2008), pp 140 – 148 E. Debefve, B. Pegaz, H. van den Bergh, G. Wagnières, N. Lange, J.–P. Ballini, “Video monitoring of neovessel occlusion induced by photodynamic therapy with verteporfin (Visudyne®), in the CAM model”, Angiogenesis (2008), pp 235 – 243 E. Debefve, B. Pegaz, H. van den Bergh, G. Wagnières, N. Lange, J.–P. Ballini, “Video monitoring of neovessel occlusion induced by photodynamic therapy with verteporfin (Visudyne®), in the CAM model”, Angiogenesis (2008), 11(3) pp 235243 A. Stenzl, D. Jocham, P. Jichlinski, K. Junker, F. König, H. van den Bergh, B. Volkmer, D. Zaak, J. Gschwend, “Photodynamic diagnostics in the urinary tract. Consensus paper of the working group for oncology of the German Society for Urology”, Urologue A. (2008), 47(8), pp 982-987 Debefve, E., Pegaz, B., Ballini, J.-P., Konan, Y.N. and van den Bergh H., “Combination therapy using aspirin-enhanced photodynamic selective drug delivery”, Vascular Pharmacology (2007), 46(3), pp 171-180

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Current Group 1 Group Leader 1 Senior Scientist 5 Scientists 2 PhD Students 1 Scientific Collaborator 1 Administrative Assistant 1 Senior Technician

2007-2009 External Grants received at the EPFL Novartis 2007-2010 Fonds Jacobi 2008-2012

CHF 300’000 CHF 1’900’000

FN-Bronchoscopy (REQUIP) 2007-2009

CHF 224’000

CTI-Photoderma 2007-2009

CHF 370’000

AMD Biolitec 2006-2009

CHF 170’000

Accord Richard Wolf 2008-2010

CHF 347’000

Collaborations & Networks Some accomplishments from recent collaborations with industry : - Development of the laser system for Visudyne therapy of age related macular degeneration with Novartis Ophthalmics (CH), Coherent Medical (USA) and Carl Zeiss (D). About one million treatments completed world wide. - Development of hexvix, the drug used in the detection of early stage bladder cancer with Photocure (N) and General Electric Health Care (USA). Accepted in 26 European countries as the new standard method for detection of cancer in the bladder. - Development of an autofluorescence endoscope with R. Wolf GmBH (D). About 300 of these endoscopes sold worldwide. Some other recent advances : - A Lidar (optical radar) was designed, constructed for, and delivered to MeteoSwiss, which rapidly measures water vapor and temperature, height resolved, up to the stratosphere. - A quantum cascade laser based open path system was developed to measure average O3, H2O and CO2 as well as temperature and turbulence over several km optical path. Teaching Activities Teaching in ENAC until september 2008, before moving to STI. 2009 : Biophotonics summer school - Ven, Sweden

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Cellular Biotechnology Laboratory Florian Wurm, Full Professor (SV/SB) Florian Wurm received his Ph.D. in molecular biology and genetic work in 1979 at the University of Giessen in Germany. From 1980 to 1985, he led a research group within the Department of Virology of Behringwerke, Marburg, Germany. In 1985, he joined the arvard Medical School in Boston, Massachusetts as a visiting lecturer. From 1986 to 1995 he held the position of "Scientist, Senior Scientist,Project Team Leader and Senior Manager at Genentech, Inc. San Francisco, California. In 1995 he was appointed professor at the Ecole Polytechnique Fédérale de Lausanne, and then full professor in 1998. Professor Wurm is a consultant and member of several scientific societies and national organizations, including ESACT (European Society of Animal Cell Technology). He recently founded a biotechnology start-up in Monthey Switzerland (ExcellGene SA) Keywords: Mammalian cell culture, recombinant protein expression, orbital shaking technology, transient gene expression, DNA integration, microinjection, stable cell line development, bioreactor. http://lbtc.epfl.ch/ Research Interests Research at the LBTC is situated on the crossroads between biology and engineering, and it addresses the expression of recombinant proteins from suspension cultures of mammalian cells, which is the major approach to therapeutic protein production in modern biotechnology industry. We are investigating three major thematic areas: (i) gene delivery and transient gene expression, (ii) orbital shaking technology for the cultivation of animal cells in suspension, and (iii) novel methods of gene transfer and integration for the generation of high-producing stable cell lines.

2007-2009 Significant Publications S. Chenuet, M. Derouazi, D. Hacker and F. Wurm, “DNA delivery by microinjection for the generation of recombinant mammalian cell lines”, Methods Mol Biol. (2009), 518:99-112 D.L. Hacker, M. De Jesus and F.M. Wurm, “25 years of recombinant proteins from reactor-grown cells - Where do we go from here?”, Biotechnol Adv. (2009), X. Zhang, M. Stettler, D.D. Sanctis, M. Perrone, N. Parolini, M. Discacciati, M.D. Jesus, D. Hacker, A. Quarteroni and F. Wurm, “Use of Orbital Shaken Disposable Bioreactors for Mammalian Cell Cultures from the Milliliter-Scale to the 1,000-Liter Scale”, Adv Biochem Eng Biotechnol. (2009), S. Nallet, M. Amacker, N. Westerfeld, L. Baldi, I. König, D.L. Hacker, C. Zaborosch, R. Zurbriggen and F.M. Wurm, “Respiratory syncytial virus subunit vaccine based on a recombinant fusion protein expressed transiently in mammalian cells”, Vaccine (2009), E.M. Engelhardt, S. Houis, T. Gries, J. Hilborn, M. Adam and F.M. Wurm, “Suspension-adapted Chinese hamster ovary-derived cells expressing green fluorescent protein as a screening tool for biomaterials”, Biotechnol Lett (2009), 31(8):1143-9 Zhang, X., Stettler, M., Reif, O., Kocourek, A., Dejesus, M., Hacker, D. L., and Wurm, F. M. , “Shaken helical track bioreactors: Providing oxygen to high-density cultures of mammalian cells at volumes up to 1000 L by surface aeration with air”, N Biotechnol (2008), 25, 68-75 Wulhfard, S., Tissot, S., Bouchet, S., Cevey, J., De Jesus, M., Hacker, D. L., and Wurm, F. M., “Mild hypothermia improves transient gene expression yields several fold in Chinese hamster ovary cells”, Biotechnol Prog (2008), 24, 458-465. Backliwal, G., Hildinger, M., Hasija, V., and Wurm, F. M., “High-density transfection with HEK-293 cells allows doubling of transient titers and removes need for a priori DNA complex formation with PEI”, Biotechnol Bioeng (2008), 99, 721-727. Backliwal, G., Hildinger, M., Chenuet, S., Wulhfard, S., De Jesus, M., and Wurm, F. M., “Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions”, Nucleic Acids Res (2008), 36, e96 Stettler M, Zhang X, Hacker DL, De Jesus M, Wurm FM, “Novel orbital shake bioreactors for transient production of CHO derived IgGs”, Biotechnol Prog (2008), Nov-Dec;23(6):1340-6 Hildinger M, Baldi L, Stettler M, Wurm FM., “High-titer, serum-free production of adenoassociated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells.”, Biotechnol Lett (2007), Nov; 29 (11):1713-21

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1. Gene delivery and transient gene expression. We have studied the cellular uptake and disassembly of PEI-DNA complexes in mammalian cells, and by combining our knowledge of cellular metabolism in suspension cultures with our most recent results we were able to dramatically increase recombinant protein productivity from transiently transfected cells. We achieved the highest titers ever reported for a transiently expressed recombinant antibody (1 g/L) in mammalian cells. This was obtained in an orbitally shaken, non-instrumented cultivation system, and is now being upscaled to 100 and 1’000 Liters (see below). 2. The orbitally shaken bioreactor technology for mammalian cell cultivation, designed in our lab, has been scaled-up to 1’000 L with a custom-made research bioreactor. This and other orbitally shaken cylindrical vessels (with nominal volumes from 50 mL to 250 L) are being extensively studied in order to characterize the hydrodynamics of this type of agitated systems. For these studies we have formed collaborations with the Professor Alfio Quarteroni (Chair of Modelling and Scientific Computing) and Dr. Mohamed Farhat of the Laboratory of Hydraulic Machines to study the fluid dynamics in orbitally shaken bioreactors. 3. Gene transfer and integration strategies for the generation of high-producing cell lines. Stable cell line development has had an important impact on biotechnology. Methods have been constantly innovated over time, as the general knowledge of the molecular mechanisms of gene integration have become better understood. Our research has focused on one cell line, CHO, which is the most widely used cell line in the biotech industry. We have investigated in collaboration with researchers at the CHUV in Lausanne the cytogenetics of CHO-derived stable cell lines generated using different DNA delivery techniques, and extensively analysed the clonal stability of these cell lines over time. We have also investigated microinjection as a tool for DNA delivery for cell line generation, which allows quantitative delivery of plasmid DNA inside a single cell. We are also investigating biological gene delivery for cell line generation using lentiviral vectors and transposons. Overall, our research provided useful insights for understanding cell cultivation in suspension, gene integration and protein expression. These studies are of general interest in biotechnology (gene therapy, protein production, industrial biotechnology). Through our research we also provide innovative tools for industrial applications and development.

Collaborations & Networks During the past years we have established a large number of collaborations with academic institutions and with the biopharmaceutical industry. Funded by a major grant from the Swiss Science Foundation, we have established, in collaboration with a Swiss company and three other university labs in Lausanne, a CHO-based production process for a human recombinant anti-RhD – immunoglobulin. The process was transferred to a GMP-manufacturer and provided clinical material that has been tested in phase II clinical trials. Another collaborative agreement was initiated in the 2000 with the American company Vaxgen Inc., for the development of a production process for HIV gp120, a candidate vaccine against HIV.

Current Group 6 PhD Students 3 Visiting Students 2 Administrative Assistants 3 Technicians 1 Scientist 1 Undergraduate Student 2 Senior Scientists 1 Postdoctoral Fellow

The majority of these past collaborations served us as models to establish a scalable bioreactor based protein production technology using transient gene expression. Our lab is the pioneer for scalable transient gene expression since we reported in the year 2001 on the first transient gene expression approach for protein production using a 100 L- scale bioreactor. Presently we collaborate actively with Prof. Alfio Quarteroni (Chair of Modelling and Scientific Computing) and Dr. Mohamed Farhat of the Laboratory of Hydraulic Machines to study the fluid dynamics in orbitally shaken bioreactors. Teaching Activities Life Sciences and Technologies Advanced biotechnology I (SPH SSV SCGC) Advanced biotechnology II (SPH SSV) Biotechnology lab (for CGC) (SCGC)

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The Centers

Center of MicroNano Technology Philippe Flückiger, Director of Operations Since 1999 Philippe Flückiger is the Director of Operations at the EPFL Center of MicroNanoTechnology, a world-class state-of-the-art cleanroom dedicated to research and development in the field of Micro- and Nano- Fabrication. He received his PhD in physics from the University of Neuchâtel, Switzerland. From 1993 to 1994 he was a post doc at Stanford University in the group of Calvin Quate, inventor of the AFM. From 1995 to 1997 he was employed by Micronas SA in Bevaix, Switzerland, a microelectronics company. The Center of MicroNano technology is a world-class technological platform dedicated to research in micro- and nanofabrication. The Center serves a dynamic, interactive community of topnotch researchers but also as a forum where interdisciplinary science is the rule rather than the exception. The Center is open to all researchers (academic organizations and industry) Keywords: Micro- and Nano Fabrication, Technological platform. http://cmi.epfl.ch/

Grants & Funding Funding is done through EPFL (consumable, maintenance, energy), STI (salaries) as well as the users through user’s fees and service revenues. The total budget is above 5 MCHF/year, not counting capital expenditure as well as the amortization of equipment. Collaboration and network During the year 2008, more than 220 researchers utilized the CMI shared facilities. They are employed by 40 EPFL laboratories, 5 external laboratories and 17 private companies. The users breakdown (# of participants) is as follow: School of Engineering: 49% School of Basic Sciences: 5% School of Life Science: 2% Other EPFL: 6% Universities: 1% Other research centers: 1% ETHZ: 3% CSEM: 3% Industry: 24% Teaching activities The intellectual core of CMI is supported by a research community comprised of 40 laboratories of EPFL, 5 external laboratories and 17 private companies, all conducting research in the Center. The staff of the CMI also plays a vital role maintaining and developing both the know-how and the infrastructure, incorporating the latest fabrication techniques and ensuring processes are stable and well characterized. The staff of the CMI offer individual consulting to the researchers helping them select the right technological options for their particular project. The staff then train the researchers individually to operate the scientific equipment Research activities Research conducted by these researchers (see the list under: http://cmi.epfl.ch/projects/files/Research_2009.pdf) summarized in our annual report) spans an exceptionally broad range including biology, medicine, microelectronics, mechanics, optics, photonics, MEMS, material sciences and nanotechnology. Most recent publications See annual report and the list above together with the publications by the individual labs.

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Equipment and Infrastructure A complete set of state-of-the-art equipment is offered to the researchers in 1000 m2 of class 100 cleanrooms. The available processes include photolithography, electron beam lithography, dry and wet etching, FIB, oxidation and thin films deposition, polishing (CMP), anodic bonding, electroplating, dicing, and SEM. 21 MCHF have been invested for the processing equipment and more than 13 MCHF for the infrastructure of the CMI.

Group and Staff 1 Managing director 9 Engineers 4 Technicians 1 Administrative Assistant 3 Trainees

Structures down to 10nm can be fabricated at CMI on 100mm and 150 mm wafers as well as piece parts by using processes derived from the microelectronic industry and cutting edge nano-fabrication techniques. A wide collection of materials is available.

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Interdisciplinary Center for Electronic Microscopy Cécile Hébert, Director Associate Professor (SB), Head of Spectrometry and Microscopy Laboratory (SB) Cécile Hébert was born in France in 1970. She obtained her Engineering degree (physics) and her PhD degree (design of a new energy filter for transmission electron microscopy, under the direction of Prof. B. Jouffrey) at the Ecole Centrale in Paris. As a post doc with Prof. P. Schattschneider, she was working on the calculation of the fine structure of ionisation edges in EELS. As a research assistant at the Vienna University of Technology, she was one of the main participant to the CHIRALTEM project dealing with the measurement of magnetic circular dichroism in the electron microscope. She joined EPFL in May 2007. Prof. C. Hébert is also affiliated to the FSB-IPMC and the LSME laboratory. Her research project are run under this affiliation and therefore not counted into CIME’s project. The interdisciplinary center for electron microscopy (CIME) at EPFL hosts all the TEM (transmission electron microscope) and most of the SEM (scanning electron microscope) at EPFL. CIME has three main missions: service and training, teaching and research in electron microscopy. Keywords: Electron microscopy, surface analysis. http://cime.epfl.ch/

Grants & Funding The financing is covered at 70 to 75% by the three main user’s Schools: Basic Science, Engineering and Life Science and roughly at 25 to 30% by an income from billing of the microscopes beam time and users training. Funding of CIME through third party projects of users: - CTI project Development of welding technology for the construction of new small guide wires for neurological applications. Total budget: CHF 1’026’921.-. Budget for CIME: CHF 306’289 - Eifer-project in collaboration with EPFL-LENI: Redox stability of Anode supported SOFC. Total budget: € 635’607 Budget for CIME: € 69’576 - Industrial project : Projet SLID: Réalisation de soudures hermétiques par interdiffusion solide-liquide. Total Budget: CHF 143’160. Budget for CIME: CHF 71’580 - OFEN project in collaboration with LENI : AccelenT (Accelerated Testing of SOFC Components):, (Jan van Herle). Budget for CIME ca. CHF 20’000 - CTI project Profiled photovoltaic modules. Total Budget: CHF 1’710’100, Budget for CIME: CHF 231’000 - CTI project: Development of material resistant to high pressure aluminum and magnesium die casting. Total Budget: CHF 1’020’097, Budget for CIME: CHF 341’542 - Collaboration with IMT/EPFL-PVLab Characterization of photovoltaic cells, approx. CHF 12’000 - Industrial collaboration: 3D imaging and EDX analysis at high lateral resolution with combined focused ion beam and scanning electron microscope, Budget for CIME: CHF 384’132 - FNS project: Nanoscale optical and structural properties of group-III nitrides semiconductors microactivities studied by S(P)TEM, EEL- and CL-spectrum imaging. Budget CHF 117’000

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Equipment and Infrastructure The electron microscopy techniques covered at CIME can be divided into three categories: transmission electron microscopy (TEM), scanning electron microscopy (SEM) and focused ion beam (FIB). The Center has 3 SEMs all equipped with EDX (FEI XL30, XL30 +EBSD, XL30 Sirion), 5 TEMs (FEI CM10, CM12, CM20 & CM300 FEG HRTEM; Jeol JEM2200FS), and 1 FIB (Zeiss Nvision40) machines available through a booking system for registered and trained users. The techniques covered are described into more detail in the main audit report, Chapter 4.7.3. In addition CIME is hosting the recently created surface analysis facility Collaboration and network CIME offers its services to all EPFL Schools, but currently four are using it: SB, SV, STI and ENAC.

Teaching activities Besides the training activities, CIME is also involved in teaching at various level: the courses on electron microscopy is given at the bachelor, master and doctoral school level. In addition, the Center has also an education and science promotion role for high-school pupils, daughter’s day, etc Research Activities Research activities at CIME are oriented towards development of new Electron Microscopy techniques and their application to existing problems. It is a priority to concentrate on techniques that are relevant to the activities of the other EPFL labs. CIME does not produce samples to be investigated. As a consequence CIME has no research project alone and most of them are in collaboration with other institutes or laboratories, some in collaboration with industries. The external lab or industry brings the problems to solve and the samples to investigate while CIME offers the technique and develop them to offer top-level and unique investigation tools. The following electron microscopy techniques are developed at CIME - Cathodoluminescense in the STEM. A Gatan mono-CL system is fitted on the newly installed JEOL 2200 FS FEG TEM with in-column omega-filter. This is one of the few instrument to be fitted with such a device (3 or 4 around the world) project leader: Pierre Stadelmann. Linked to projects of N. Grandjean (SB-IPEQ) who provides the samples and to the activity of B. Deveaud-Plédran & J.D. Ganière (SBIPEQ) who develop CL-SEM and time-resolved CL-SE. - Computational electron microscopy. The JEMS program for high resolution image simulation and diffraction pattern calculation including all aberrations of the microscope as well as dynamical effects is being developed by Pierre Stadelmann since more than 20 years. More than 1’000 licenses of the program have been sold to labs and industries around the world.

Group and Staff 1 Adjunct Professor 2 Scientists 4 Scientific Collaborators 1 Engineer 1 Senior Technician 5 Technicians 2 Administrative Assistants 1 Trainee 4 PhD Students 4 PhD Students (external)

- Electron Energy Loss Spectrometry (EELS) is a powerful tool for chemical analysis but can in addition give unique information about the electronic state on a very localized scale. In particular, low loss EELS gives access to the angular resolved loss function at very high lateral resolution and in combination with all structural informations obtainable by electron microscopy. - High resolution TEM (HRTEM). With the CM300 acquired in 1991, and the competences especially in image simulation for interpretation, CIME has been a leading center in the field of HRTEM. Not owning a Cs corrected microscope makes it now impossible to compete with the international state of the art, but the development of nanomaterials, nano particles as well as highly sophisticated multi-layered materials in many labs at EPFL makes it increasingly important to rebuild this activity. It is therefore in the future objectives. 2007 – 2009 Significant Publications These are the publications by CIME’s team members. More than 100 journal publications by EPFL groups come every year that made use of CIME. When the image acquisition and interpretation is made independently, CIME does not request to be coauthor. 1. He, Z.B., Stolitchnov, I., Setter, N., Cantoni, M., Wojciechowski, T., Karczewski, G. HREM studies of twins in Cd1-x Zn x Te (x ≈ 0.04) thin films grown by molecular beam epitaxy (2009) Journal of Alloys and Compounds, . Article in Press. . 2. Hébert, C., Bartova, B., Cantoni, M., Aydemir, U., Baitinger, M. TEM and SEM investigation on oxidised Ge-based clathrates (2008) Microscopy and Microanalysis, 14 (SUPPL. 2), pp. 1142-1143. . 3. C. Senatore, R. Flukiger, M. Cantoni, G. Wu, R. H. Liu, and X. H. Chen. Upper critical fields well above 100 T for the superconductor SmFeAsO0.85F0.15 with T-c=46 K Physical Review B 78 (2008). 4. V. K. Parashar, J. B. Orhan, A. Sayah, M. Cantoni, and M. A. M. Gijs Borosilicate nanoparticles prepared by exothermic phase separation Nature Nanotechnology 3, 589 (2008). continued over page

- 3D microscopy and EDX analysis with FIB (focused ion beam) nanotomography. This technique is becoming increasingly important especially since the manufacturers brought to the market the last generation of FIBs with high resolution electron column.

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5. A. Faes, A. Hessler-Wyser, D. Presvytes et al., " Nickel–Zirconia Anode Degradation and Triple Phase BoundaryQuantification fromMicrostructural Analysis", accepted in Fuel Cell, DOI: 10.1002/ fuce.200800147

14. F. Cordella, M. de Nardi, E. Menna, C. Hébert and M.A. Loi Tuning the photophysical properties of soluble single-wall carbon nanotube derivatives by co-functionalization with organic molecules carbon, Vol. 47, pp. 1264–1269, 2009.

6. A. Faes, A. Nakajo, A. Hessler-Wyser et al., "RedOx study of anode supported solid oxide fuel cell", accepted in Journal of Power Sources, 2008, doi:10.1016/j.jpowsour.2008.12.118.

15. Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: Physicochemical and magnetic properties, in vitro and in vivo drug release. Butoescu, N ; Jordan, O ; Burdet, P ; Stadelmann, P et al. In: EUROPEAN JOURAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 72, num. 3, 2009, p. 529-538. Date: 2009

7. C. Monachon, A. Hessler-Wyser, A. Faes et al., "Rapid Preparation and SEM Microstructural Characterization of Nickel-Yttria-Stabilized Zirconia Cermets", J. Am. Ceram. Soc., 91 [10] 3405-3407, 2008. 8. A. Faes, Q. Jeangros, J. B. Wagner et al., "in situ réduction and oxidation of nickel from solid oxide fuel cells in a transmission electron microscope", submitted to Electrochemical Society Transactions. 9. P. Schattschneider, C. Hébert, S. Rubino, M. Stöger-Pollach, J. Rusz, and P. Novak. Magnetic circular dichroism in EELS: Towards 10 nm resolution. Ultramicroscopy, 108:433–438, 2008. 10. C. Hébert, P. Schattschneider, S. Rubino, P. Novak, J. Rusz, and M. Stöger- Pollach. Magnetic circular dichroism in electron energy loss spectrometry. Ultramicroscopy, 108:277–284, 2008. 11. Jian Zhang, Dangsheng Su, Aihua Zhang, Di Wang, Robert Schlögl, and Cécile Hébert. Nanocarbon as robust catalyst : Mechanistic insight into carbon- mediated catalysis. Angewandte Chemie, 46(38):7319– 7323, 2007. 12. J. Verbeeck, C. Hébert, P. Schattschneider, S. Rubino, P. Novak, J. Rusz, F. Houdellier, and C. Gatel. Optimal aperture sizes and positions for EMCD experiments. Ultramicroscopy, 108(9):865–872, 2008. 13. P. Schattschneider, S. Rubino, M. Stoeger-Pollach, C. Hebert, J. Rusz, L. Calmels, and E. Snoeck. Energy loss magnetic chiral dichroism: A new technique for the study of magnetic properties in the electron microscope (invited). Journal of applied physics, 103:07D931, 2008.

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16. Preparation of BN microtubes/nanotubes with a unique chemical process Bechelany, M. ; Brioude, A. ; Stadelmann, P. ; Bernards, S. et al. In: Journal of Physical Chemistry C, vol. 112, num. 47, 2008, p. 1832518330, Date: 2008 17. Large vacuum Rabi splitting in a multiple quantum well GaN-based microcavity in the strong-coupling regime. Christmann, G. ; Butté, R. ; Feltin, E. ; Mouti, A. et al. In: Physical Review B - Condensed Matter and Materials Physics, vol. 77, num. 8, 2008, p. 085310 18. Knott GW, Holtmaat A, Trachtenberg JT, Svoboda K, Welker E (2009) A protocol for preparing GFP-labeled neurons previously imaged in vivo and in slice preparations for light and electron microscopic analysis. Nature Protocols 4:1145-1156. 19. Holtmaat A, Bonhoeffer T, Chow DK, Chuckowree J, De Paola V, Hofer SB, Hubener M, Keck T, Knott G, Lee WC, Mostany R, Mrsic-Flogel TD, Nedivi E, Portera-Cailliau C, Svoboda K, Trachtenberg JT, Wilbrecht L (2009) Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nature Protocols 4:1128-1144. 20. Rapid functional maturation of nascent dendritic. Zito K, Scheuss V, Knott G, Hill T, Svoboda K (2009) spines. Neuron 61:247-258. 21. Imaging of experience-dependent structural plasticity in the mouse neocortex in vivo, Holtmaat A, De Paola V, Wilbrecht L, Knott GW (2008) Behavioural Brain Research 192:20-25.

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22. Dendritic spine plasticity--current understanding from in vivo studies. Knott G, Holtmaat A (2008) Brain Research Rev 58:282-289. 23. Serial section scanning electron microscopy of adult brain tissue using focused ion beam milling. Knott G, Marchman H, Wall D, Lich B (2008) J Neurosci 28:2959-2964. 24. Growth structures of ZnO transparent electrical contacts for thinfilm silicon solar cells, D.T.L. Alexander, S. Nicolay, M. Cantoni, S. Faÿ, and C. Ballif, printed abstract and poster presentation Microscopy Conference 2009 in Graz, August 30 – September 4, 2009.

Whenever the needs are not sufficient to justify the relatively long training, investigations are performed by CIME’s staff members seconded by CIME's PhD students and post docs. CIME staffs members are also present to answer questions by the users or to help them with the interpretation of data. In 2008, the total usage amounted to 12’000 beam hours, split as follow between users: - STI: 36%, CIME : 23%, Teaching: 11%, SB: 16%, SV: 6%, ENAC: 2%, other EPFL-Services : 5% and external:1%. and instruments: - SEMs: XL30 EBSD: 19%; XL30: 19%; XL30 SFEG: 9%; HF2000: 3% - TEMs: CM300: 17% ; CM20: 12% ; CM10: 10% ; CM30: 7% ; - FIB: 4%

Service and training activities 250 users from 40 different EPFL labs are using CIME's microscopes. With very little personnel for many machines (CIME is one of the TEM centers with the least scientific staff per instrument), it is impossible to perform investigations for all users. Therefore, as soon as the user’s needs exceed a certain level, the user is trained to the technique(s) needed so that investigations can be performed as independently as possible. Each person requesting training is asked to fill a project sheet reviewed by CIME’s staff in order to judge if the requested technique is relevant to solve the addressed problems. The trainings are going deep into the field and offer theoretical background as well as a practical training on the instrument, representing about 20 hours of direct contact with the teachers. Trainees are mainly PhD students and post Docs. Approx. 100 trainings sessions are provided every year (about 20 % of them are for existing users on a technique new to them) and there is a large turnover of the users as most of them stay between 2 and 4 years at EPFL Whenever the needs are not sufficient to justify the relatively long training, investigations are performed by CIME’s staff members seconded by CIME's PhD students and post docs. CIME staffs members are also present to answer questions by the users or to help them with the interpretation of data. In 2008, the total usage amounted to 12’000 beam hours, split as follow between users: - STI: 36%, CIME : 23%, Teaching: 11%, SB: 16%, SV: 6%, ENAC: 2%, other EPFL-Services : 5% and external:1%. and instruments: - SEMs: XL30 EBSD: 19%; XL30: 19%; XL30 SFEG: 9%; HF2000: 3% - TEMs: CM300: 17% ; CM20: 12% ; CM10: 10% ; CM30: 7% ; - FIB: 4%

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Center for Neuroprosthetics Jeffrey Hubbell, Director Full Profesor (SV/SB/STI), Director of the Insitute of Bioengineering, Merck Serono chair in Drug Delivery, Head of Regenerative Medicine and Pharmacobiology Laboratory Jeffrey Hubbell obtained his B.S. in Chemical Engineering from Kansas State University in 1982, followed by a Ph.D. in Chemical Engineerign from Rice University in 19986. He was then successively Assistant and Associate Professor at the University of Texas, Austin from 1986 to 1995, then Professor of Chemical Engineering at Caltech from 1995 to 1997 before becoming Material Science professor at ETHZ in 1998. In 2004, he joined the EPFL as Full Professor of bioengineering, affiliated to the School of Engineering and the School of Life Science (bioengineering Institute) but also to the School of Basic Science (Chemical Engineering). The Center for Neuroprosthetics will be active at the crossroads between fundamental research (theoretical and experimental), clinical applications and market opportunities. The center will concentrate on six main themes: vision (retinal implants), hearing (cochlear implants), mobility (cortical and spinal implants), non-invasive man-machine interfaces (piloting at distance, robotics), the micro-and nano-fabrication of implants, and neuronal coding (signal processing, sensors). Keywords: neuroprosthetics, vision, hearing, mobility, brain, sensors. http://neuroprosthetics.epfl.ch/

Grants and funding Generous donations received from the Defitech Foundation, the Foundation Bertarelli, the Sandoz Family Foundation as well as the International Institute for Research in Paraplegia (IRP) are helping financing the center that should be provided with the following chairs: - Defitech Foundation Chair in Non-invasive Brain-machine Interface - Sandoz Family Foundation Chair on Neural Coding and Neuroprosthesis - Foundation Bertarelli Chair in Neuroengineering and Neuroprosthetics (open) - Foundation Bertarelli Chair in Neurophysiology and Coding of Cochlear implants (open) - Foundation IRP Chair in Spinal cord Neuroprosthetics (open) The search process is still ongoing in order to progressively fill the open positions hopefully until Mid 2010 Collaboration and network The Center is formally part of EPFLâ&#x20AC;&#x2122;s School of Engineering, in collaboration with the School of Life Sciences and the School of Computer and Communication Sciences. The center will also develop col-laborations with other institutions in the Lake Geneva area, such as University of Lausanne and the Cantonal Hospital (CHUV), University of Geneva and its hospital (HUG), and the regional biomedical industry.

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Teaching Activities See teaching activities of prof. J. Hubbel and J. Millán Research Activities José del R. Millán was hired as associate professor in April 2009 from the IDIAP Research Institute in Martigny, Switzerland and is occupying the Defitech Foundation Chair in Non-invasive Brain-machine Interface. He is currently coordinating a large European integrated project in the area of “tools for brain-computer interaction” (TOBI). 2007-2009 Significant Publications See publication of prof. J. Millán - Defitech Foundation Chair in Non-invasive Brain-machine Interface (CNBI)

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Space Center Maurice Borgeaud, Director Dr. Maurice Borgeaud earned an EPFL degree in Electrical Engineering, then a Master of Science and a Ph.D. Degree from the Massachusetts Institute of Technology, both in Electrical Engineering and Computer Science. He worked in 1988 for the German Aerospace Agency (DLR) in Munich and was then member of the staff of the European Space Agency (ESA) from 1989 to 2002 at the European Space Research and technology Center (ESTEC). During this time, he was responsible for several space technology and Earth observation projects. He also spent a one-year sabbatical leave at the NASA/Caltech Jet Propulsion Laboratory (JPL) in 1992. From 2002 to 2004, he was affiliated with the Swiss Space Office in Berne and was member of the Swiss delegation to ESA where he was in charge of the Earth observation, satellite navigation and communications sectors. Since September 2004, he has been appointed Director of the Space Center EPFL. M. Borgeaud is a Senior Member of the IEEE, was an associate Editor for both the “IEEE Transactions on Geoscience and Remote Sensing” and the “Journal of Electromagnetic Waves and Applications”. He has authored and co-authored more than 100 publications in refereed journals or conference proceedings. Since 2008, Maurice Borgeaud has been elected Chairman of the ESA Program Board on Earth observation. The mission of the Space Center EPFL is to promote and develop space activities by involving Swiss education, science and industries around internationally recognized R&D and application projects and missions, as well as around top-class education and training for students and industry.

Grants and funding Industrial, institutional, academic, and other Swiss partners: total of CHF 3’150’000 over the time period 2007 to 2009 Collaborations & Networks The Space Center EPFL has created a network of academic partners in Switzerland with the HES-SO, university of Neuchâtel and the FHNWBrugg. In addition, it has a strong partnership with the members of the Steering Committee of the Space Center EPFL such as RUAG Aerospace, Oerlikon Space, CSEM, and the Swiss Space Office. Thanks to the SwissCube project, the Space Center EPFL has also created a dense network with several European universities active in the design and construction of small satellites. Before joining the Space Center EPFL, most of the staff of the Space Center EPFL was active in the space sector, either with the European Space Agency or at NASA/JPL which makes easy to link and connect with these space agencies. In addition, a very good cooperation has been established with BMSTU in Moscow (Bauman Moscow State Technical University).

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Keywords: Space research and technology, Satellite development and micro-satellite design, System Group and staff 8 Scientific Collaborators engineering, Applications for Earth observation, Mars and planetary exploration. http://space.epfl.ch 1 PhD student (external) 2 Master students Equipment and Infrastructure The Space Center EPFL has developed Concurrent Design Facility, similar to what can be found at ESA and 10 undergraduate students NASA, in order to foster the development of system engineering for complex projects which could be applied to both space and non-space projects.

Service and training activities The Space Center EPFL organizes and co-organizes specific events such as the Space Research Days. In addition, it can provide services through its Concurrent Design Facility that can be rented by entities or companies external to the EPFL. Teaching Activities The staff of the Space Center EPFL is currently teaching the following courses in the frame of the Minor in space technologies (Master level). ‘Remote sensing of the Earth by satellites’, ‘Spacecraft design and system engineering’, ‘Introduction to planetary sciences’. In addition, the ESA astronaut and EPFL Professor Claude Nicollier also teaches a class in the frame of the Minor: ‘Space technologies and operations’. Research Activities In terms of research, the Space Center EPFL is interested in four main domains: - System engineering for space (and non-space) applications: The concurrent design facility (CDF) is an environment where engineers of different specialties come together to perform system engineering studies for a project. The design process is facilitated by the co-location of specialists in one room with access to all necessary information and tools, and special software that enables instantaneous data exchange during the design process. CDFs have been founded at ESA and NASA research centers as well as in the industry. - Development of micro-satellites: The Space Center EPFL, in cooperation with Swiss academic and industrial partners has built a nano-satellite of 1 Kg during the period 2006-2009. Its primary goal is educational, in the sense that students learn how to build a complex engineering system from A to Z. Though the satellite is rather small in size, a cube with sides of 10cm for a weight of 1 Kg, it contains all the critical sub-systems and functions present in larger satellites. SwissCube has also a scientific goal to image the night-glow luminescence created by the recombination of atoms of oxygen at 100 Km of altitude and a technological aim to study a new generation of Earth-sensors for satellites.

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- Earth observation by satellites: More and more satellites are being launched to observe the Earth. The research activities of the Space Center EPFL deal with the improvement of the comprehension on how electromagnetic waves interact with the Earth surfaces so that signals collected by satellites may be better understood. The goal is to develop new models and retrieval algorithms to derive bio- and geo-physical parameters for land applications using remote sensing data acquired by satellites. - Planetary exploration: The Space Center EPFL is currently involved in the interpretation of data collected by several satellites orbiting Mars to derive Digital Elevation models (DEM) from image stereo pairs and to characterize water ice deposits on Mars using subsurface sounding data. 2007-2009 Significant Publications B. Koetz, K. Itten, M. Borgeaud, D. Brunner, B. Buchmann, C. Fiegenwinter, F. Hüsler, M. Kneubühler, E. Parlow, A. Psomas, S. Wunderle, N. E. Zimmermann, ‘Hyper-Swiss-Net: Fostering the Swiss Research Community in the Field of Imaging Spectroscopy’ , EARSeL Imaging Spectrometry Workshop (March 2009), N. Ackermann, L. Ling, M. Borgeaud, E. Chen, Z. Li, ‘Identification of tropical forested areas using a synergetical approach with SAR satellite imagery’, ESA Dragon Symposium (July 2009), M. Noca, F. Jordan, N. Steiner, T. Choueiri, F. George, N. Scheidegger, H. Peter-Contesse, M. Borgeaud, R. Krpoun, and H. R. Shea, ‘Lessons Learned from the First Swiss Pico-Satellite: SwissCube’ , 23rd Annual AIAA/USU Conference on Small Satellites, (August 2009), M. Borgeaud, N. Scheidegger, M. Noca, G Roethlisberger, F. Jordan, T. Choueiri, and N Steiner, ‘SwissCube : The first entirely-built Swiss student satellite with an Earth observation payload’ , Chapter of a Springer book (Accepted for publication, 2009),

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Interinstitutional Center of Translational Biomechanics Brigitte Jolles-Haeberli, Director Adjunct Professor, Doctor of Medecine, Privat-Docent Senior Scientist (CHUV/UNIL) A citizen of Liechtenstein, Brigitte Jolles-Haeberli studied microtechnology engineering at EPFL in 1990, and earned her federal diploma and doctor of medicine degree from the University of Lausanne in 1995. She then continued her training in hospitals in Vaud and Geneva, as well as at St. Michel Hospital and the University of Toronto in Canada. In 2002 she was awarded her federal diploma as a Swiss Medical Association specialist in orthopedic surgery and traumatology. Her academic advancement at the University of Lausanne included the titles of tenured senior lecturer and research group leader in 2003 and privat-docent in 2005. In 2008 she became an adjunct professor at EPFL, and took the managing responsibility for the Interinstitutional Center of Translational Biomechanics. The mission of the Inter-institutional Center of Translational Biomechanics (CBT) is to promote and support the transfer of findings from basic science of the laboratory to clinical application, but also observation from clinic back to the lab, with a clear aim at improving patient care. Besides, the key point of this collaboration is based on double-headed management, with a strong relationship between a clinician and an engineer, for each specific project. Keywords: Gait analysis (in lab, ambulatory in field, long-term monitoring), Biomechanics of joints and implants, Foetal cell therapy, Tissue engineering, Orthopaedic surgery, Rehabilitation, Sports Medicine. http://cbt.epfl.ch/

Grants & funding The Center is funded both by the EPFL and the “Fondation de Soutien de l’hôpital orthopédique”. So far, 1’200 kCHF is shared every year. Beside, the CBT constituting labs are free regarding other sources of funding. They are considered as EPFL labs as far as third party funding is concerned. Collaborations & Networks The Center has established a series of collaboration other research institutions or industrial partners, within but also outside EPFL: EPFL - Composites and Polymer Technology Laboratory (Dr. P.E. Bourban) - Automatic Control Laboratory(Dr. P. Muellhaupt) - Signal Processing Laboratory 5 (Prof. J-P. Thiran) - Microsystems Laboratory 2 & 4 (Prof. M. Gijs, Prof. P. Renaud) - Electronics Laboratory 1 (Prof. C. Dehollain) - Microengineering for Manufacturing 2 (Prof. P. Ryser, Dr E. Meurville) - Geodetic Engineering Laboratory (Prof. B. Merminod) Switzerland - Department of Bone Diseases, HUG, Geneva (Prof. S. Ferrari, Prof. J.Caverzasio) - Department of Orthopaedic Surgery, HUG ; Geneva (Prof. P. Hoffmeyer, Dr Anne Lubbeke-Wolff, Dr S. Armand) - Genomic Research Laboratory, HUG ; Geneva (Dr J. Schrenzel) - Microengineering Institute, University of Neuchatel (Prof. PA. Farine) - CRR – SUVA, Sion (Prof. C. Gobelet, Dr F. Luthi) - Inselspital, Bern - MEM Research Center, Institute for Surgical Technology & Biomechanics, Bern (Dr. Urs Müller). - Tissue Engineering Laboratory, University Hospital of Basel (Prof. I. Martin) - Musculoskeletal Research Unit, University of Zurich (Prof. B. von Rechenberg) - ETHZ - AO Research Institute, Davos (Prof. K. Ito) - Department of Orthopaedic Surgery, Kantonales Spital SurseeWolhusen, Lucerne (Dr P. Schai) - Swiss Federal Department of Sport Macolin OFSPO - Swiss ski alpine national team (S. Allemand) - Swiss ski jumper national team (F. Cuendet)

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Europe - IRMAR, University of Rennes 1, France (Prof. L. Rakotomanana) - INSERM, University of Nantes, France (Prof. J.M. Bouler) - INSERM, Departement of Biostatistics and Medical Computing, University of Paris and Hôpital Saint-Louis, France (Dr. D. Biau). - University of Aix-Marseille, Hôpital Sainte Marguerite of Marseille, France (Prof. J-N. Argenson, Dr S. Parratte) - Department of Orthopaedic Surgery, Yvette Clinic of Longjumeau, France (Dr C. Delaunay, President of the French Hip and Knee Society) - Department of Orthopaedic Surgery, Medico-surgical Clinic, Bruayen-Artois, France (Dr J-A. Epinette) - Department of Orthopaedic Surgery, Hôpital Pitié Salpétrière, University of Paris, France (Prof. Y. Catonné and Dr E. Sariali) - Biomechanics Laboratory, Istituti Ortopedici Rizzoli, University of Bologna, Italy (Dr S. Martelli) - Robert-Bosch Krankenhaus, Deutschland - University of Grönigen, Netherlands - Department of Orthopaedics, Leiden University Medical Center (LUMC), Netherlands (Dr B.L. Kaptein) International - University of Bergen, Norway - Department of Mechanical Eng., Stanford University, USA (Prof. C. Jacobs) - Rosalind Franklin University of Medicine and Science, Oregon Health and Science University, USA - Image and Orthopaedic Research Laboratory (LIO), Université de Montréal, Canada (Prof. R. Aissaoui) - Epidemiology Program, Toronto Western Hospital, University of Toronto, Canada (Prof. P. Côté) - Mobility Department, St. Michael's Hospital, University of Toronto, Canada (Prof. E.R. Bogoch) - Department of Biotechnology, IIT Madras, India (Prof. A. Jayakrishnan)

School of Engineering

Group and staff 1 Adjunct Professor 1 Associate Professor 2 Group Leaders 1 Engineer 10 PhD Students 1 MD, Professor 2 Technicians 2 Postdoctoral Fellows 2 Senior Technicians 3 MDs

INDUSTRIES - Felco - Fischer ski - GE Healthcare Finland Oy - IMEC (NL) - Logitech - Mathys Medical AG - Medtronic - Rolex - Smith & Nephew - Stryker, Osteosynthesis Division - Symbios OrthopĂŠdie SA - Telealarm - Tornier Implants Chirurgicaux - Zimmer Research activities - Develop new tools for a truly objective analysis of surgical results in orthopaedic surgery and for the analysis of joint pathology (long-term ambulatory gait-analysis, instrumented implants,...) - Develop new approaches to design new treatments of orthopaedic lesions (finite element analysis of joints and implants, joint neuromuscular modelling and bone remodelling, tissue engineering, foetal cell therapy,...) - Develop new methods to analyse sports performance and to prevent orthopaedic lesions (swiss national team or leisure sports activities, rehabilitation,...)

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Integrated Systems Center Giovanni De Micheli, Director Full Professor (STI/IC), Director of the Institute of Electrical Engineering, Head of the Laboratory of Integrated Systems Giovanni De Micheli is Professor and Director of the Institute of Electrical Engineering and of the Integrated Systems Center at EPF Lausanne, Switzerland. He also chairs the Scientific Committee of CSEM, Neuchatel, Switzerland. Previously, he was Professor of Electrical Engineering at Stanford University. He received the 1987 D. Pederson Award for the best paper on the IEEE Transactions on CAD/ICAS, two Best Paper Awards at the Design Automation Conference, in 1983 and in 1993, and a Best Paper Award at the DATE Conference in 2005. The Integrated Systems Center is an interfaculty center to promote activities between the School of Engineering, The School of Computer and Communication Sciences as well as the School of Life Science. The center researches different design aspects for integrated systems on Silicon, as well as on heterogeneous platforms including, but not limited to, electrical, optical, micromechanical and biological components in various forms and mixtures. The center has spurred several transversal activities, and has been the incubator of the nanotera.ch (www.nano-tera.ch) initiative. The scientific projects include topics at the intersection of various disciplines, such as electrical engineering, computer science, biology and medicine. Keywords: Integrated systems on silicon; heterogeneous platforms; electrical, optical, micromechanical and biological components. http://si.epfl.ch/

Collaboration & Networks The Center has associated faculty members who contribute to the development of its activities - Embedded Systems Laboratory – ESL (Prof. David Atienza) - Microsystems Laboratory – LMIS 1 (Prof. J. Brugger) - Integrated Systems Laboratory – LSI (Dr. Sandro Carrara, Dr. Nadia Khaled) - Integrated Systems Laboratory – LSI (Prof. Christian Enz, EPFL and CSEM) - Microsystems Laboratory – LMIS 2 (Prof. M. Gijs) - Nanoelectronic Devices Laboratory – NANOLAB (Prof. Adrian Ionescu) - Microelectronic Systems Laboratory – LSM (Prof. Yusuf Leblebici) - Swiss-up engineering Chair - Laboratory of Life Sciences Electronics (STI/SV)) – CLSE (Prof. Carlotta Guiducci) - Group Kayal – Electronics (Prof. Maher Kayal) - Group Mattavelli – Video processing – SCI-STI-MM (Dr. Marco Mattavelli) - Group Ijspeert – IC-BIRG (Prof. Auke Ijspeert) - Quantum Architecture Group – AQUA Group (Prof. Edoardo Charbon, EPFL and TU Delft, NL) - Systemic Modeling Laboratory – IC-LAMS (Prof. Jean-Dominique Decotignie) - Processor Architecture Laboratory – IC-LAP (Prof. Paolo Ienne) - Distributed Intelligent Systems and Algorithms Laboratory – ENAC-DISAL (Prof. Alcherio Martinoli) - Sensory Processing Laboratory – LSENS (Prof. Carl Petersen) - Processor Architecture Laboratory – IC-LAP (Prof. Christian Piguet) Teaching Activities The Center SI has been organizing weekly seminars and summer schools, most notably on “Geometric Programming” (2006), ”Frontiers of Nanoscale Electronics” (2008), “Nanoelectronic Circuits and Tools” (29 june – 3 July, 2009) and “Nano-bio-sensing” (14-18 July, 2009)

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Research Activities The scientific projects include topics at the intersection of various disciplines, such as electrical engineering, computer science, biology and medicine. Research and education in heterogeneous integrated systems require a departure from previous models. The complexity and breadth of the issues at stake is possibly unprecedented. There are several ingredients that are necessary to perform excellent and relevant research in this area. The first one is to have the pool of competences that goes beyond the capability of a single laboratory. The second ingredient is a continuous interaction with the industrial world, to provide a feedback mechanism on the realistic impact of research done within the university domain, as well as to provide a path to physical realization of ideas, which cannot be completely done within the university. Projects of the supported by the CSI include: - A Methodology for Controlling and Exploiting Self-Assembly across Length-Scales - Bio-Optical System-on-chip Based on CMOS Single Photon Avalanche Diode Technology - Fault-Tolerant Design of Memory Arrays and PLAs With Failure-Prone Nanometer-Scale Technologies - Gate-all-Around Silicon Sub-Micron Devices and Integrated Photonics for On-Chip Signaling - Advanced Cell-Electronics Interface for Implanted Devices and Brain-Machine Interaction - Generic Scavenger Powered DSP-Based System-on-Chip for Emerging Implantable Biosensors and Bioactuators - Building 3D Silicon Architectures - Perfomance Monitoring for professional and recreation sports using WSM - GALS interfAce for compleX digital sYstem integration (FP7: GALAXY) - Enabling Nano-Bio-Chip Technologies for Sensing Applications

2007-2009 Significant Publications - AQUA Group Publications (Edoardo Charbon) see http://aqua.epfl.ch/publications.html - BIRG Publications (Auke Ijspeert) see http://birg2.epfl.ch/publications/ - CARG Publications (Gianluca Tempesti) http://lslwww.epfl.ch/pages/staff/tempesti/publi.htm - LAP Publications (Paolo Ienne) http://lap.epfl.ch/page68175.html - NANOLAB Publications (Adrian Ionescu) http://nanolab.epfl.ch/publications.htm - GR-KA Publications (Maher Kayal) http://elab.epfl.ch/publications.htm - LMIS Publications (Martin Gijs) http://lmis2.epfl.ch/?page=search_publication&type_selected=journal - LSI Publications (Giovanni De Micheli, Christian Enz) http://lsi.epfl.ch/page13139.html - LSM Publications (Yusuf Leblebici) http://lsm.epfl.ch/page13405.html

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