Diabetes mellitus is one of the most widely prevalent endocrine disorder of carbohydrate metabolism. Over the last couple of years, there has been a significant rise in diabetes mellitus cases worldwide. Sedentary lifestyle coupled with unhealthy dietaries leads to obesity which in turn is fueling diabetic cases. Glucose sensors is a compact analytical device or a unit incorporating a biological or biologically derived sensitive recognition element integrated with physiochemical transducer. Self-monitoring blood glucose investigated in diabetes mellitus is essential for insulin treatment or oral glucose lowering medication to provide information of glucose concentrations in our body. These sensors has proved quite efficient in monitoring the glucose level in human body, thus gaining wide popularity among healthcare practitioners for assessment purpose.