CATALOGUE
HORSE FEEDS
YOUR COMPLETE VETERINARY SUPPLY AND SUPPORT SOLUTION
ABOUT EUROVETS EUROVETS IS YOUR COMPLETE VETERINARY SUPPLY & SUPPORT SOLUTION Eurovets, established in 2001 has become the Middle East’s foremost supplier of some of the world’s best known veterinary products to veterinary clinics throughout the UAE. We represent leading multi-national brands in nutrition, veterinary equipment, medicines and consumables for companion, -equine and production animals. In addition to the traditional wholesaling, Eurovets provides warehousing, distribution, marketing and sales resources in order to support the product in the region. We also offer a host of value-added services such as maintenance and support for all equipment supplied; service-based offerings such as Spectrum allergy testing; even end-to-end IT solutions for clinics. Eurovets supports Continued Professional Development, imparting knowledge of the latest developments in the field to veterinary professionals through high-powered seminars. We pride ourselves on our professional approach and offer vet specialized product advice where required. In conclusion our mission is to not only deliver excellent products but to be committed to deliver exceptional customer service to all veterinary clinics and pet retailers in the region. Eurovets YOUR headquarters for veterinary supply and support and a proud distributor of Qalian products.
ABOUT QALIAN The company is involved in product design through to production and sale in France and abroad. an Unique player in the market, Qalian develops at a single laboratory in France three large families of complementary products for animal well-being and health. This include Veterinary medicines sold in over 40 countries. Veterinary dietary specialties that support and reinforce the physiological functions of an organism and improves the performance and wellbeing of animals in each development stage. And lastly they also develop and distribute a wide range of animal and livestock hygiene products. www.qalian.com
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INDEX
Page Medicines Coxaprol. . . . . . . . . . . . . . . . . . . 4 Diaziprim
. . . . . . . . . . . . . . . . . . 5
Disthelm . . . . . . . . . . . . . . . . . . . 6 Doxoral . . . . . . . . . . . . . . . . . . 7-8 Enrosol . . . . . . . . . . . . . . . . . . 9-10 Hypersol . . . . . . . . . . . . . . . . . 11-12 Milicoli . . . . . . . . . . . . . . . . . . . 13 Tiamisol . . . . . . . . . . . . . . . . . 14-15 Tyloral . . . . . . . . . . . . . . . . . . 16-17
Dietetics Antitox . . . . . . . . . . . . . . . . . . . 18 Bicalphos . . . . . . . . . . . . . . . . . . 19 B-Max . . . . . . . . . . . . . . . . . . . 20 Carnitol-L . . . . . . . . . . . . . . . . . . 21 C-Vet . . . . . . . . . . . . . . . . . . . . 22 Livoral . . . . . . . . . . . . . . . . . . . 23 Toniselen . . . . . . . . . . . . . . . . . . 24 Ucavit AD3E . . . . . . . . . . . . . . . . . 25 Vitaflash . . . . . . . . . . . . . . . . . . 26
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VÉTÉRINAIRE
Oral solution V07022012EAL
MEDICINES
COXAPROL
LA B O R AT O I R E
Poultry
COMPOSITION
PRECAUTIONS FOR USE
Amprolium (as hydrochloride)............................................. 106 mg Excipient ......................................................................... QS 1 mL
Special precautions for use in animals Renew medicated drinking water each 24 hours.
PHARMACOLOGICAL PROPERTIES Pharmacotherapeutic group : Internal antiparasitics, other antiprotozoal agents ATCvet code : QP51AX09. Pharmacodynamic properties Amprolium is a coccidiostat which belongs to the thiamine analogues family. Amprolium acts by interfering as a competitive antagonist of thiamine within thiamine transport mechanisms. It interferes in the carbohydrate metabolism required for coccidies multiplication and survival.
Special precautions to be taken by the person administering the medicinal product to animals Avoid a direct contact with skin. Wash hands after use. In case of accidental projection in eyes, flush with plenty of wate. If irritation persists, seek for medical advice and show the label. In case of accidental ingestion, consult a doctor. Special precautions for the disposal of unused drugs or materials derived from the use of these drugs The empty packaging and any remaining product should be removed following the practices governed by waste regulations.
Pharmacokinetic caracteristics Amprolium is weakly absorbed after oral administration. Maximum plasma drug concentration is reached 4 hours later. Amprolium is excreted mainly via faeces.
WITHDRAWAL PERIOD
INDICATIONS Poultry : Treatment of coccidiosis.
Meat and offal : zero days Eggs : zero days
ADMINISTRATION AND DOSAGE Oral route. 20 mg of amprolium per kg body weight per day, for 5 to 7 days i.e. 2 mL of oral solution per 10 kg body weight per day, for 5 to 7 days. The oral solution should be diluted in drinking water according to amount of medicinal drinking water consumed by animals, in order to comply with the weight dosage (in mg / kg).
OVERDOSE A prolonged use at high doses can induce thiamine deficienc. This deficiency can be compensated by a thiamine intake
STORAGE Shelf-life : 24 months After opening : 3 months After dilution in drinking water : 24 hours
CATEGORY Veterinary use. Prescription only. Adhere to prescribed doses.
PACKAGING 100 mL can 500 mL can 1 L can 2 L can 5 L can Not all pack sizes may be marketed.
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Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
VÉTÉRINAIRE
Oral solution V29072011EAL
MEDICINES
DIAZIPRIM
LA B O R AT O I R E
COMPOSITION
SPECIAL WARNINGS FOR EACH TARGET SPECIES
Sulfadiazine ................................................................... 83.35 mg Trimethoprime ............................................................... 16.65 mg Excipient ......................................................................... Q.S 1 ml
Do not administer to laying hens uses to produce eggs for human consumption
PHARMACOLOGIC PROPERTIES Therapeutic group : anti-infectives for systemic use. ATC-vet code : QJ01EW10 Pharmacodynamic properties Sulfadiazine is a long-acting sulfamide with a broad spectrum of activity. It is active against Gram-positive and Gram-negative germs. Trimethoprim belongs to the family of diaminopyrimidines. It is active against streptococci and most of the Gram-negative bacteria. In combination, these two active substances are synergetic. Sulfadiazine is potentiated by a diaminopyrimidine, the trimethoprim. The combination of these two active substances allows a sequential blocking of the biosynthesis of folic acid. Both substances act sequentially on the synthesis of acid tetrahydrofolic, the sulfamide inhibiting the incorporation of acid para amino benzoic in the folic acid, the trimethoprim inhibiting specifically the microbial dehydrofolate reductase. The theoretical spectrum of activity extends to both Gram-positive bacteria (Staphylococcus, Listeria ...) and Gram-negative bacteria (Escherichia coli, Salmonella, Proteus, Enterobacter, Bordetella ...). Pharmacokinetic particulars Sulfadiazine is considered as a slow-acting sulfamide with a long persistence of plasma levels. Its fixation to plasma proteins is important. The distribution is good in most of tissues and organs. Trimethoprim is rapidly absorbed after oral administration. It is widely distributed in the body. The two active ingredients are partially metabolized in the liver. Their elimination is essentially renal.
USE DURING PREGNANCY, LACTATION OR LAY Laboratory studies in animals have shown evidence of teratogenic and foetotoxic effects at doses exceeding the recommended therapeutic doses. The use is not recommended during pregnancy and lactation.
Lambs
PRECAUTIONS FOR USE Special precautions to be taken by the person administering the medicinal product to animals People with known hypersensitivity to sulfadiazines should avoid contact with the product. Do not eat, drink or smoke while handling the product. If any symptom should appear, such as a cutaneous eruption, seek prompt medical advice and show the package leaflet or the label to the doctor. Swelling of the face, lips or eyes or respiratory difficulties are the most serious signs with require urgent medical attention.
Poultry
Rabbits
Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products, if appropriate Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
INDICATIONS
WITHDRAWAL PERIOD
Treatment of infections caused by microorganisms sensitive to sulfadiazine and trimethoprim.
Meat and offal : 12 days. Eggs : do not use in laying birds producing eggs for human consumption, 4 weeks before laying starts and during laying.
In calves, lambs, rabbits and poultry : Prevention and treatment of respiratory and gastrointestinal infections
Calves
CONTRAINDICATIONS Do not use in case of hypersensitivity to sulfadiazine or trimethoprim. Do not use in animals with severe renal or hepatic dysfunction.
STORAGE ADMINISTRATION AND DOSAGE Oral route. Calves, lambs : 12.5 mg of sulfadiazine and 2.5 mg of trimethoprim / kg body weight / 12 hours, for 4 – 7 days, i.e. 1.5 ml of solution / 10 kg body weight / 12 hours, for 4 – 7 days, to mix with the milk feed (when adding the water). Poultry and rabbits : 25 mg of sulfadiazine and 5 mg of trimethoprim / kg body weight / day for 4 – 7 days, i.e. 3 ml of solution / 10 kg body weight / day for 4 to 7 days, to be diluted in drinking water or liquid food. The uptake of medicated water or liquid feed depends on the clinical condition of the animals. In order to obtain the correct dosage the concentration of sulfadiazine and trimethoprim has to be adjusted accordingly.
24 months. After first opening : 3 months. After dissolving in drinking water : 12 hours. After dissolving in milk : 2 hours
CATEGORY Veterinary use. Prescription only. Adhere to prescribed doses.
FRENCH MARKETING LICENCE (AMM) : FR/V/8645630 0/2000
PACKAGING CAN 1 L CAN 2 L CAN 5 L CAN 10 L
GTIN 03661753028986 GTIN 03661753016877 GTIN 03661753016884 GTIN 03661753028993
Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
PAGE 5
VÉTÉRINAIRE
Oral suspension V21072011EAL
MEDICINES
DISTHELM 2,5%
LA B O R AT O I R E
COMPOSITION
USE DURING PREGNANCY, LACTATION OR LAY
Albendazole ..................................................................... 25.0 mg Benzoic acid (E210) ............................................................ 1.8 mg Potassium sorbate (E 202)................................................... 1.5 mg Excipient ............................................................................ QS 1 g
Studies in laboratory animals (mice, rats, rabbits) and in sheep have shown a teratogenic effect of albendazole. The use is contraindicated in pregnant female during the first third of gestation.
PHARMACOLOGICAL PROPERTIES
PRECAUTIONS FOR USE
Pharmacotherapeutic group : Antiparasitic product, benzimidazole. ATC vet code : QP52AC11
special precautions for use in animals Body weight should be determined as accurately as possible, before calculating the dose. Resistance to this class of anthelmintics can develop when using too frequent and repeated an anthelmintic of this class.
pharmacodynamic properties Albendazole is an anthelmintic of the benzimidazole family. It works by interfering in the energy metabolism of parasites. Anthelmintic efficacy is based on the inhibition of tubulin polymerization into microtubules. The destruction of the microtubular system often leads to the disintegration and cell death. In ruminants, albendazole exhibits activity on gastrointestinal roundworms (including the encysted larvae of Haemonchus and Ostertagia spp) on the lung roundworms, tapeworms, and the adult flukes, albendazole has also ovicidal activity. pharmacokinetic caracteristics Albendazole is metabolized in the liver to albendazole sulfoxide, albendazole sulphone and albendazole 2-aminosulfone. In general, the elimination of albendazole and its metabolites is via the faeces and to a smaller part in the urine and milk.
special precautions to be taken by the person administering the medicinal product to animals Avoid direct contact with the skin. Wash hands after use. Wear suitable clothing including impermeable rubber gloves when using the product. In case of accidental ingestion, seek medical attention. special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products, if appropriate Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements
INDICATIONS in sheep and goat : Treatment of the following parasites infestations: • Gastrointestinal roundworms (adults and L4 larvae): Trichostrongylus spp, Haemonchus contortus, Cooperia curticei, Nematodirus spp., Bunostomum trigonocephalum, Strongyloides papillosus, Oesophagostomum venulosum, Chabertia ovina. • Lungworms (adults and L4 larvae): Dictyocaulus filaria • Tapeworms: Moniezia spp • Trematodes: Fasciola hepatica, Dicrocelium lanceolatum
WITHDRAWAL PERIOD Meat and offal : 10 days. Milk : In the absence of a withdrawal period, do not use in lactating dairy females.
CONTRAINDICATIONS Do not use in animals with known hypersensitivity to the active substance(s). Do not use if resistance to benzimidazoles is suspected.
SPECIAL WARNINGS FOR EACH TARGET SPECIES Do not use in female dairy (see section «withdrawal time»).
ADMINISRTATION AND DOSAGE In sheep : • Gastro-intestinal roundworms, lungworms and tapeworms : 3.8 mg of albendazole per kg bodyweight, i.e. 1.5 mL per 10 kg bodyweight in a single oral administration. • Fluke (adult) : 7.5 mg of albendazole per kg bodyweight, i.e. 3 mL per 10 kg bodyweight in a single oral administration. • Small flukes (adults) : 15 mg of albendazole per kg bodyweight, i.e. 6 mL per 10 kg bodyweight in a single oral administration. In goats : • Gastro-intestinal roundworms, lungworms, tapeworms and liver flukes (adults) : 7.5 mg of albendazole per kg bodyweight, i.e. 30 mL per 10 kg bodyweight in a single oral administration. • Small flukes (adults) : 15 mg of albendazole per kg bodyweight, i.e. 60 mL per 100 kg bodyweight in a single oral administration. Shake the suspension before use to a good homogeneity of the product. Use a dispenser clean and properly calibrated.
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STORAGE Shelf life : 24 months After first opening : 3 months Do not store the veterinary medicinal product above 25°C
CATEGORY Veterinary use. Prescription only. Adhere to prescribed doses.
AMM N° :
FR/V/0195210 8/1986
PACKAGING CAN 1 LITRE CAN 2 LITRE CAN 5 LITRE
GTIN 03353239013370 GTIN 03353239013387 GTIN 03353239013394
Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
Sheep
Goat
VÉTÉRINAIRE
powder for oral solution for chickens
Powder for oral solution V07022012EAL
MEDICINES
DOXORAL 500 mg/g
LA B O R AT O I R E
Chickens broilers, broiler breeders
COMPOSITION Doxycycline (as hyclate) ..................................................... 500 mg Excipients ........................................................................... QS 1 g
Based on the recommended dose, and the number and weight of the animals to be treated, the exact daily amount of DOXORAL should be calculated according to the following formula :
PHARMACOLOGICAL PROPERTIES
mg of doxycycline / kg Mean body weight (kg) body weight / day X of animals to be treated
Therapeutic group : Antibiotic for systemic use, tetracycline. ATC-vet code : QJ01AA02. Pharmacodynamic properties Doxycycline binds reversibly to receptors on the 30S ribosome, thereby blocking the binding of aminoacyl-tRNA to the corresponding site on the messenger RNA-ribosome complex. This inhibits protein synthesis and therefore halts bacterial growth (the effect is therefore predominantly bacteriostatic). The bacteriostatic effect of doxycycline requires its penetration into the bacterial cell. This penetration takes place both by passive diffusion (cross-membrane transfer) and by an active mechanism (requiring an energy source and by definition can therefore be saturated). The principal resistance mechanism possible is due to the presence of an R factor responsible for decreasing the active transport of doxycycline. Doxycycline is a broad-spectrum antibiotic, active against a large number of Gram-positive and Gram- negative, aerobe and anaerobe microorganisms, Mycoplasmata, Chlamydiae and Rickettsia. Cross resistance to other tetracyclines is possible. This resistance is habitually of plasmid origin. Continuous treatment with low concentrations of doxycycline may also lead to other antibiotics. Pharmacokinetic caracteristics Doxycycline is rapidly (2-3 h) absorbed after administration by oral route and its bioavailability is approximately of 70 % in mostly of species. Plasma protein binding is high (over 90%). Because doxycycline is highly lipid soluble compared with other tetracyclines of 1st generation, doxycycline is widely distributed in the organism. It reaches well watered tissues as well as peripheral tissues. The highest concentrations of doxycyclines have been reported in lungs, kidneys, liver and spleen. Doxycycline cross the placenta. Doxycycline is excreted via the bile but a large proportion is reabsorbed by the small intestine (enterohepatic cycle). 40% of doxycycline is metabolized and excreted in feces mainly as conjugated inactive metabolites.
INDICATIONS Chickens : Treatment of clinical respiratory infections associated with Mycoplasma gallisepticum susceptible to doxycycline.
ADMINISTRATION AND DOSAGE To be administered in drinking water. Chickens : 20 mg doxycycline per kg of body weight daily (corresponding to 40 mg product per kg of body weight), administered in the drinking water for 5 consecutive days.
Mean daily water consumption(l) per animal
= mg of doxycycline / litre of drinking water
To ensure a correct dosage body weight should be determined as accurately as possible. The uptake of medicated water is dependant on the clinical conditions of the animals. In order to obtain the correct dosage, the concentration in drinking water may have to be adjusted. The use of suitability calibrated weighing equipment is recommended if part packs are used. The daily amount is to be added to the drinking water such that all medication will be consumed in 24 hours. Medicated drinking water should be freshly prepared every 24 hours. It is recommended to prepare a concentrated pre-solution – approximately 100 grams product per litre drinking water – and to dilute this further to therapeutic concentrations if required. Alternatively, the concentrated solution can be used in a proportional water medicator.
WITHDRAWAL PERIOD Chickens : 5 days Eggs : Not permitted for use in laying birds producing eggs for human consumption
STORAGE Shelf-life : 18 months After opening : 6 months Store in the original container tightly closed in order to protect from moisture. Do not store above 25°C.
CATEGORY Veterinary use. Prescription only. Adhere to prescribed doses.
FRENCH MARKETING LICENCE (AMM) : PACKAGING 100 G SACHET 200 G SACHET 500 G JAR 1 KG JAR
Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
PAGE 7
OVERDOSE
Doxycycline may form insoluble complexes with divalent ions, especially iron or calcium, zinc and magnesium.
During the target animal tolerance study, no adverse effect was observed even at the fivefold therapeutic dose administered for two times the recommended duration in either target animal species. If suspected toxic reactions do occur due to extreme overdose, the medication should be discontinued and appropriate symptomatic treatment should be initiated if necessary.
Do not use in case of hypersensitivity to the active substance or to any of the excipients. Do not use when tetracycline resistance has been detected in the flock due to the potential for cross resistance. Do not use in animals with hepatic dysfunction.
SPECIAL WARNINGS FOR EACH TARGET SPECIES The uptake of medication by animals can be altered as a consequence of illness. In case of insufficient uptake of drinking water, animals should be treated parenterally. Do not administer to poultry whose eggs are intended for human consumption.
ADVERSE REACTIONS As for all tetracyclines, on rare occasions allergic reactions and photosensitivity may occur. If suspected adverse reactions occur, treatment should be discontinued. If you notice any serious effects or other effects not mentioned in this leaflet, please inform your veterinary surgeon.
USE DURING PREGNANCY, LACTATION OR LAY Laboratory studies in rats and rabbits have not produced any evidence of a teratogenic, foetotoxic, maternotoxic effects. Do not use in birds in lay and within 4 weeks before the onset of the laying period.
INTERACTION WITH OTHER MEDICINAL PRODUCTS AND OTHER FORMS OF INTERACTION Do not administer concurrently with feed overloaded with polyvalent cations such as Ca2+, Mg2+, Zn2+ and Fe3+ because the formation of doxycycline complexes with these cations is possible. Do not administer together with antacids, kaolin and iron preparations as tetracyclines are bacteriostatic antimicrobials, do not administer in conjunction with bactericidal antibiotics like beta-lactames. It is advised that the interval between administration of other products containing polyvalent cations should be 1-2 hours because they limit the absorption of tetracycline. Doxycycline increases the action of anticoagulants.
PAGE 8
Chickens broilers, broiler breeders
PRECAUTIONS FOR USE Special precautions for use in animals Inappropriate use of the product may increase the prevalence of bacteria resistant to tetracycline due to the potential for cross resistance. Due to variability (time, geographical) in susceptibility of bacteria for doxycycline, bacteriological sampling and susceptibility testing of microorganisms from diseased birds on farm are highly recommended. A high resistance rate of E. coli , isolated from chickens, against tetracyclines has been documented. Therefore the product should be used for the treatment of infections caused by E. coli only after susceptibility testing has been carried out. As eradication of the target pathogens may not be achieved, medication should therefore be combined with good management practices, e.g. good hygiene, proper ventilation, no overstocking. Use of the product should be based on susceptibility testing and take into account official and local antimicrobial policies. Special precautions to be taken by the person administering the medicinal product to animals Direct contact of the product with the skin, eyes and mucous membranes should be avoided. People with known hypersensitivity to tetracyclines should avoid contact with the veterinary medicinal product. Wear protective gloves and goggles when reconstituting or administering the solution. Wash exposed skin after preparation. In case of accidental projection into the eyes, rinse abundantly with water. Do not smoke, eat or drink when handling the product. In case of accidental ingestion, seek medical advice immediately and show the label to the physician. Inflammation of the face, lips or eyes or respiratory difficulties are the most serious signs which require urgent medical attention. Special precautions for the disposal of unused drugs or materials derived from the use of these drugs The empty packaging and any remaining product should be removed following the practices governed by waste regulations.
Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
Powder for oral solution
CONTRAINDICATIONS
DOXORAL 500 mg/g
MEDICINES
INCOMPATIBILITIES
VÉTÉRINAIRE
Oral Solution V01062012EAL
MEDICINES
ENROSOL 10%
LA B O R AT O I R E
COMPOSITION
ADMINISTRATION AND DOSAGE
Enrofloxaci ....................................................................... 100 mg Excipient ......................................................................... QS 1 mL
For oral administration via the drinking water. This may be put directly into the header tanks, or via water proportioner systems. Dosage : 10 mg of enrofloxacin per kg bodyweight per day for 5 consecutive days Medication of the water supply should be continuous during the treatment period and no other source of water should be available. Medicated water should be made every day, immediately prior to provision. Carefully calculate the total body mass to be treated and the total daily water consumption before each treatment. The uptake of medicated water depends on age and clinical condition of the animals, ambient temperature, and light regime. In order to obtain the correct dosage the concentration of the product should be adjusted accordingly. Taking into consideration that 10 mg enrofloxacin per kg body weight corresponds to 0.1 ml of the product per kg body weight; the following calculation should be made to provide the required amount of the product per litre of drinking water:
PHARMACOLOGICAL PROPERTIES Pharmacotherapeutic group : Fluoroquinolone ATCvet code : QJ01MA90 Pharmacodynamic properties Enrofloxacin is a synthetic broad spectrum antimicrobial substance, belonging to the fluoroquinolone group of antibiotics It is bactericidal in action with activity against a range of Gram positive and Gram negative bacteria and mycoplasmas. The mechanism of action of the quinolones is unique among antimicrobials – they act primarily to inhibit bacterial DNA gyrase, an enzyme responsible for controlling the supercoiling of bacterial DNA during replication. Resealing of the double standard helix is inhibited resulting in irreversible degradation of the chromosomal DNA. The fluoroquinolones also possess activity against bacteria in the stationary phase by an alteration of the permeability of the outer membrane phospholipid cell wall. Resistances to fluoroquinolones occur primarily by alterations in bactericidal cell wall penetration. Permeability changes occurs either via decreased permeability of the hydrophilic pores or through alteration of the active transport (efflux) pump thereby decreasing the intracellular content of fluoroquinolones Pharmacokinetic caracteristics The pharmacokinetics of enrofloxacin are such that oral and parenteral administration leads to similar serum levels. Enrofloxacin possesses a high distribution volume. Tissue levels 2 – 3 times higher than that found in the serum, have been demonstrated in laboratory animals and target species. Organs in which high levels can be expected are the lungs, liver, kidney, skin, bone and lymphatic system. Enrofloxacin also distributes into the cerebrospinal fluid and the aqueous humou. Following oral administration of enrofloxacin in rabbits the maximum concentration reaches between 0.5 to 2.5 hours. The maximum concentration after administration of a therapeutic dose is between 1 – 2.5 µg/ml. The degree of metabolism depends on the species and ranges between 50-60%. Biotransformation at hepatic level of enrofloxacin results in the active metabolite, ciprofloxacin In general, metabolism is by hydroxylation and oxidation processes to oxofluoroquinolones Other reactions that also occur are N-dealkylation and conjugation with glucoronic acid. Excretion occurs by biliary and renal route, with excretion in the urine predominating.
0.1 ml Average bodyweight product per kg of animals to be Number bodyweight X treated (kg) X of animals Total water consumption (l) of the flock at the previous day
Chickens
Turkeys
Rabbits
= ml product per litre of drinking water
Care should be taken that the intended dose is completely ingested. Use appropriate and properly calibrated dosing equipment.
WITHDRAWAL PERIOD Meat and offal Chickens : 4 days Turkeys : 4 days Rabbits : 2 days Eggs : Not permitted for use in laying birds producing eggs for human consumption. Do not use within 4 weeks of onset of lay.
STORAGE Shelf-life : 24 months After opening : 6 months After dilution in drinking water : 24 hours
CATEGORY
INDICATIONS In poultry and turkey: Treatment of diseases of the respiratory tract due to Escherichia coli or / and Mycoplasma gallisepticum, where clinical experience and/or sensitivity testing indicates enrofloxacin as the drug of choice In rabbits: Treatment of diseases of the respiratory tract due to P. multocida.
Veterinary use. Prescription only. Adhere to prescribed doses.
PACKAGING 1 Litre can
CONTRAINDICATIONS Do not use in birds producing eggs for human consumption. Do not use for prophylaxis. Do not use in cases of confirmed or suspected, resistance to quinolones. Do not use in cases of hypersensitivity to the active substance.
Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
PAGE 9
Special precautions for use in animals Before use, header tanks should be emptied, thoroughly cleaned and then filled with a known volume of clean water before adding the required amount of product. The resulting mixture should be stirred. Before use, header tanks should be inspected at regular intervals for presence of dust, algae formation and sedimentation. Official and local antimicrobial policies should be taken into account when the product is used. Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials. Wherever possible, fluoroquinolones should be used based on susceptibility testing. Use of the product deviating from instructions given in the SPC may increase the prevalence of bacteria resistant to fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance. If there is no clinical improvement within two to three days susceptibility testing should be repeated and therapy should be changes, if appropriate.
In rabbit, enrofloxacin crosses the placental barrier and is excreted through the milk. When using the product in lactating rabbits should be taken into account that in rabbits neonates, and until at least 16 days of age, the ability of eliminate enrofloxacin is significantly less than that of adult
INTERACTION WITH OTHER MEDICINAL PRODUCTS AND OTHER FORMS OF INTERACTION Concurrent administration of enrofloxacin with other antimicrobials tetracyclines and macrolide antibiotics, may result in antagonistic effects. Absorption of enrofloxacin may be reduced if the product is administered together with substances containing magnesium or aluminium. Do not combine enrofloxacin with steroidal anti-inflammaty products.
OVERDOSE (SYMPTOMS, EMERGENCY PROCEDURES, ANTIDOTES), IF NECESSARY Do not exceed the recommended dose. In accidental overdose there is no antidote and treatment should be symptomatic.
INCOMPATIBILITIES Do not mix with any other veterinary medicinal product. Increased influx of the air (admixing CO2 from the air) into medicated drinking water may result in precipitation of enrofloxacin High concentrations of calcium and magnesium in the water system may result in precipitation of enrofloxacin during intermediate dilution in the dosage devices.
PAGE 10
Special precautions to be taken by the person administering the medicinal product to animals Wear impervious gloves when handling the product. Direct contact with the skin should be avoided because of sensitisation, contact dermatitis and possible hypersensitivity reactions. Wash any splashes from skin or eyes immediately with water. Wash hands and exposed skin after use. Do not eat, drink or smoke whilst using the product. Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
Chickens
Turkeys
Rabbits
Oral Solution
PRECAUTIONS FOR USE
Do not use in birds where eggs are intended for human consumption.
ENROSOL 10%
MEDICINES
USE DURING PREGNANCY, LACTATION OR LAY
VÉTÉRINAIRE
Powder for oral solution V03082011EAL
MEDICINES
HYPERSOL
LA B O R AT O I R E
Poultry
INDICATIONS In poultry and rabbits : Treatment and prevention of septicaemia in infected environment, of respiratory infections and digestive infections due to oxytetracycline sensitive germs.
COMPOSITION Oxytetracycline (as chlorhydrate) ............................ 0.50 g Excipient : Anhydrous citric acid ..................................... Q.S. 1.00 g
PHARMACOLOGICAL PROPERTIES Pharmacotherapeutic group : Antibiotic, Tetracyclines. ATCvet code : QJ01AA06. Pharmacodynamic properties The oxytetracycline links reversibly to the ribosomal subunit 30S receptors, leading to a blockage of the union between aminoacyltRNA and the site corresponding to the mRNA-ribosome complex messenger. It results in the inhibition of the protein synthesis and then a growth stoppage of the bacterial culture. The oxytetracycline activity is mainly bacteriostatic. The bacteriostatic activity of oxytetracycline involves penetration of the substance in the bacterial cell. Oxytetracycline penetrates by both passive and active diffusions. The main possible mode of resistance is due to the potential presence of a R factor responsible for a decrease in the active transport of oxytetracycline. Oxytetracycline is a broad-spectrum antibiotic. It is mainly active against Gram-positive and Gram negative bacteria, aerobic and anaerobic, as well as against Mycoplasma, Chlamydia and Rickettsiae. Acquired resistance to oxytetracycline has been reported. This resistance is usually a plasmid origin. Crossresistance to other tetracyclines is possible. Continuous treatment with low doses of oxytetracycline may also cause increased resistance to other antibiotics. Pharmacokinetic particulars For most species, oxytetracycline is rapidly (2-4 h) absorbed after oral administration in animals and in fasting conditions. The bioavailability is within 60% and 80%, which can be reduced in the presence of food in the stomach, as oxytetracycline leads to the formation of insoluble chelates with divalent or trivalent cations (Mg, Fe, Al, Ca). In pigs, the influence of food is negligible on the bioavailability of oxytetracycline which is less than 5%. The oxytetracycline binds variably to plasma proteins according to the species (20-40%). Its distribution is large The oxytetracycline diffuses throughout the body, the highest concentrations have been found in the kidneys, liver, spleen and lungs. The oxytetracycline crosses the placental barrier. Oxytetracycline is excreted unchanged mainly via urine. It is also excreted via biliar but a high proportion of oxytetracycline is reabsorbed by the small intestine (enterohepatic cycle).
Rabbits
ADMINISTRATION AND DOSAGE Oral route. The uptake of medicated depends on the clinical conditions of the animals. In order to obtain the recommended dosage, water uptake has to be monitored and the concentration of oxytetracycline content must be adjusted accordingly. Poultry and rabbits : 20 mg of oxytetracycline / kg body weight / day, for 3 – 5 days in drinking water, i.e. 400 mg of oral powder / L of drinking water. To take full advantage of the qualities of solubility Hypersol it is important to realize a first concentrated solution to 400 g / L (adjust the volume of water to the amount of powder) and then further diluted the first solution in the final volume of water (or reservoir tank dosing pump).
WITHDRAWAL PERIOD Meat and offal : 7 days. Eggs : zero days.
STORAGE Shelf-life : 24 months. After first opening : 6 months. After dilution in drinking water : 24 hours. 5 kg and 10 kg bags : do not store at a temperature higher than 25°C.
CATEGORY Veterinary use. Prescription only. Adhere to prescribed doses.
FRENCH MARKETING LICENCE (AMM) : FR/V/7627467 3/2010
PACKAGING 1 KG BOX 5 KG BAG 10 KG BAG
GTIN 03661753060856 GTIN 03661753060849 GTIN 03661753060832
Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
PAGE 11
PRECAUTIONS FOR USE
Do not use in case of hypersensitivity to oxytetracycline or any other substance from tetracyclines group. Do not use in case of a known resistance to tetracyclin group.
Precautions for use in animals This powder for oral solution is intended to be dissolved in liquid feed or water and can not be used as is.
INTERACTION WITH OTHER MEDICINAL PRODUCTS AND OTHER FORMS OF INTERACTION Divalent or trivalent cations (Mg, Fe, Al, Ca) may chelate with tetracyclines. The tetracylines should not be administered with antacids, gels containing aluminium, preparations containing vitamins or minerals as insoluble complexes will be formed, which decreases the absorption of the antibiotic.
ADVERSE REACTIONS As for all other tetracyclines, side effects have been observed such as intestinal disorders and less frequently, allergic and photosensibility.
Precautions to be taken by the person administering the veterinary medicinal product to animals Do not handle the product in case of known allergy due to tretracyclines. Do not eat, drink or smoke while handling the product. In case of reactions after being exposed at the product (a cutaneous eruption for example), consult the doctor. Special precaution for the disposal of unused products or waste materials derived from the use of such products, if appropriate Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements
USE DURING PREGNANCY, LACTATION OR L AY Laboratory studies in animals have not produced any evidence of embryotoxicity or teratogenic effects. In mammals, oxytetracycline crosses the placental barrier, resulting in staining of teeth and slow foetal growth. Tetracyclines are found in breast milk. Product safety has not been evaluated during pregnancy and lactation. This medicinal product will be subjected to an assessment of the beneďŹ t risk ratio by the veterinarian.
PAGE 12
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Poultry
Rabbits
HYPERSOL Powder for oral solution - Poultry and rabbits
MEDICINES
CONTRAINDICATION
VÉTÉRINAIRE
Oral solution V29072011EAL
MEDICINES
MILICOLI
LA B O R AT O I R E
The recommended daily dose should be divided into two if the product is to be administered directly into the mouth of the animal.
COMPOSITION Colistin (as sulphate) .................................... 2 000 000 IU Benzyl alcohol ...................................................... 0.01 mL Excipient ............................................................ Q.S 1 mL
Poultry : 75 000 IU of colistin per kilogram body weight daily, for 3-5 consecutive days in drinking water, i.e. 37.5 mL of solution per tonne body weigh per day for 3 to 5 days.
Calves
Lambs
PRECAUTIONS FOR USE PHARMACOLOGIC PROPERTIES Therapeutic group : Intestinal antiinfectives, polypeptides. ATC-vet code : QA07AA10. Pharmacodynamic properties Colistin is a polypeptide antibiotic belonging to the polymyxin therapeutic class. Colistin exerts bactericidal activity against susceptible bacteria strains by disruption of their cytoplasmic membrane, leading to an alteration of cell permeability and then leakage of intracellular materials. Colistin has bactericidal effects against a broad spectrum of gram-negative microorganisms, such as enterobacteriaceae and particularly, escherichia coli. Colistin presents little effect against gram-positive bacteria and fungi organisms. Gram-positive bacteria, and some species of gram- negative bacteria like proteus and serratia are naturally resistant to colistin. However, colistin-resistance acquisition by gram- negative enteric bacteria is rare and can be explained by simple mutation. Pharmacokinetic caracterictics Colistin (as sulfate) is poorly absorbed after oral administration through the intestinal barrier. In serum and tissues, the concentrations of colistin are very weak. However, colistin is present in important quantities and is persistent in the different sections of the digestive tract. No metabolism was observed. Colistin is almost exclusively excreted via faeces.
INDICATIONS In calves, lambs and poultry : treatment of gastrointestinal infections caused by Escherichia coli and Salmonella susceptible to colistin.
Special precautions to be taken by the person administering the medicinal product to animals People with known hypersensitivity to polymyxins should avoid contact with this veterinary medicinal product. In case of accidental projection in the eyes, rinse with plenty of water, seek prompt medical advice and show the package leaflet or the label to the doctor. Wash hands after use.
Poultry
Precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products, if appropriate Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
WITHDRAWAL PERIOD Meat and offal : 1 day. Eggs : zero days
STORAGE Shelf-life : 24 months. After first opening : 3 months. Do not store above 25 ° C.
CATEGORY Veterinary use. Prescription only. Adhere to prescribed doses.
ADMINISTRATION AND DOSAGE To be administered orally. The uptake of medicated water depends on the physiological and clinical condition of the animals. In order to obtain the correct dosage, the concentration of colistin has to be adjusted accordingly. Calves and lambs : 100 000 IU of colistin per kilogram body weight daily, for 3-5 consecutive days in the milk, in liquid feed or in drinking water, i.e. 0.5 mL of solution per 10 kg body weigh per day during 3 to 5 days.
FRENCH MARKETING LICENCE (AMM) : FR/V/1262476 0/1998
PACKAGING CAN 100 ML CAN 500 ML CAN 1 L CAN 2 L CAN 5 L
GTIN 03661753004218 GTIN 03661753004232 GTIN 03661753004225 GTIN 03661753021826
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PAGE 13
VÉTÉRINAIRE
Oral solution V01032012EAL
MEDICINES
TIAMISOL
LA B O R AT O I R E
COMPOSITION
ADMINISTRATION AND DOSAGE
Tiamulin (as hydrogen fumarate)................................... 101.20 mg Excipient ......................................................................... QS 1 mL
Oral route. Administer in drinking water.
PHARMACOLOGICAL PROPERTIES Therapeutic group : Anti-infective for systemic use. ATCvet Code : QJ01XQ01 Pharmacodynamic properties Tiamulin is a bacteriostatic antibiotic semisynthetic that belongs to the class of pleuromutilin, The mode of action is by inhibition of ribosomal protein synthesis in sensitive bacteria Tiamulin showed in vitro activity against a wide variety of bacteria including Brachyspira hyodysenteriae, Brachyspira pilosicoli, Lawsonia intracellularis, and Mycoplasma spp. Tiamulin is bacteriostatic at therapeutic doses and acts on the 70S ribosome, the primary binding site on the 50S subunit with a potential secondary binding site between the subunits 50S and 30S. It appears to inhibit the production of the protein by forming a complex microbial initial biochemically inactive, which prevents elongation of the polypeptide chain. The mechanisms responsible for the development of resistance to the pleuromutilin class in Brachyspira spp would be based on mutations in the ribosomal target site. The development of resistance to tiamulin clinically visible requires a combination of mutations around the binding site. Tiamulin resistance may be associated with a decreased sensitivity regarding other pleuromutilin. Pharmacokinetic caracteristics Chicken : Tiamulin is well absorbed in the chicken (70-95%) after oral administration.Tiamulin is widely distributed throughout the body and accumulates in the liver and kidneys (excretion sites), and in the lungs (30 times the serum concentration). Excretion is mainly via the bile (55-65%) and kidneys (15-30%), mainly as microbiologically inactive metabolites. It is relatively fast, 99% of the dose in 48 hours. Turkey : In turkeys, serum concentrations of tiamulin are similar to those observed in chickens. In breeding, the mean serum after administration of 0.025% tiamulin was 0.36 μg/ml (0.22 to 0.5 μg / ml).
INDICATIONS Infections due to tiamulin-susceptible micro-organisms in chickens and turkeys . Chickens : Treatment and prevention of chronic respiratory disease (CRD) and airsacculitis caused by Mycoplasma gallisepticum and Mycoplasma synoviae. Turkeys : Treatment and prevention of infectious sinusitis and airsacculitis caused by Mycoplasma gallisepticum, Mycoplasma meleagridis and Mycoplasma synoviae.
Chickens (broilers, replacement pullets, laying hens and breeding) : 20.2 mg of tiamulin per kg body weight per day, administered for a period of 3 to 5 consecutive days. The dosage is normally achieved by an incorporation rate of 20 ml of tiamulin per 100 kg in drinking water. Turkeys (poults, turkey breeders) : 32.4 mg of tiamulin per kg body weight per day, administered for a period of 3 to 5 consecutive days. The dosage is normally achieved by an incorporation rate of 32.4 ml of tiamulin per 100 kg in drinking water. The medicated water consumption depends on the physiological and clinical condition of the animals. In order to obtain the correct dosage, the concentration of tiamulin should be adjusted, Preventive treatment with tiamulin should only be initiated after confirmation of infection with M gallisepticum, M. synoviae and M. meleagridis and as an aid in the context of prevention strategy to reduce clinical signs and mortality from respiratory disease on farms, or infection of the egg is probably because the disease is known to exist in the previous generation. The prevention strategy should include actions to eliminate infection from the previous generation.
WITHDRAWAL PERIOD Meat and offal : Pigs and Turkeys : 4 days Chicken : 1 day Eggs : zero days
STORAGE Shelf-life : 24 months After opening : 6 months After dilution in drinking water : 24 hours
CATEGORY Veterinary use. Prescription only. Adhere to prescribed doses.
PACKAGING 100 mL can 250 mL can 500 mL can 1 L can 2 L can 5 L can
Not all pack sizes may be marketed.
PAGE 14
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Turkeys (poults, turkey breeders)
Chickens (broilers, replacement pullets, laying hens and breeding)
Animals should not receive products containing ionophores as monensin, narasin or salinomycin, during or for at least seven days before or after treatment. Severe growth depression or death may result. See section “Interaction with other medicinal products and other forms of interaction” for the information concerning interactions between tiamulin and ionophores.
SPECIAL WARNINGS FOR EACH TARGET SPECIES In case of depress of water intake during the administration, the incorporation rate in water may be increased to reach the target dose. Animals not drinking enough should be treated by parenteral route. Do not use if hypersensitivity to the active substance or any excipients. Do not use in case of resistance to tiamulin.
UNDESIRABLE EFFECTS (frequency and seriousness) On rare occasions erythema or mild oedema of the skin may occur in pigs following the use of tiamulin hydrogen fumarate. USE DURING PREGNANCY AND LACTATION The product can be used in laying and breeding chickens and turkeys.
INTERACTION WITH OTHER MEDICINAL PRODUCTS AND OTHER FORMS OF INTERACTION For chickens and turkeys: Tiamulin interacts with ionophores such as monensin, salinomycin and narasin. This can cause signs of poisoning indistinguishable ionophores. Animals should not receive products containing ionophores during treatment with tiamulin or for at least seven days before or after treatment with tiamulin. Severe growth depression or ataxia, paralysis or death may result. For this purpose, it must be notified to the supplier of food that tiamulin will be used and that these products must not be incorporated into the food or contaminate it. Check any presence of ionophore in the food in case of suspicion. In case of occurrence of interaction, stop treatment with drinking water containing tiamulin and replace water with clean water. Remove the contaminated food as soon as possible and replace it with a food product not incompatible with tiamulin.
The clinical signs of toxicity in chickens are: vocalization, clonic cramps and lying in a lateral position. Symptoms in turkeys are: clonic cramps, lateral or dorsal position, salivation and ptosis. If signs of poisoning are observed, withdraw rapidly the medicated water and replace it with fresh water. Appropriate symptomatic treatment should be initiated.
Turkeys (poults, turkey breeders)
PRECAUTIONS FOR USE Special precautions for use in animals Use of the product should be based on susceptibility testing and take into account official and local antimicrobial policies The inappropriate use may increase the prevalence of bacteria resistant to tiamulin and may decrease the effectiveness of treatment using substances related to tiamulin. Long term or repeated use should be avoided by improving management practice and thorough cleansing and disinfection. In the absence of a satisfactory response to treatment, the diagnosis should be reconsidered. See section «Interaction with other medicinal products and other forms of interaction» for information on the interaction between tiamulin and ionophores.
Chickens (broilers, replacement pullets, laying hens and breeding)
Special precautions to be taken by the person administering the medicinal product to animals When mixing the veterinary medicinal product, direct contact with the eyes, skin and mucous membranes should be avoided. Personal protective equipment should be worn when mixing the veterinary medicinal product or handling the medicated water: a pair of overalls, impervious gloves and either a disposable half-mask respirator in accordance with European standard EN 149 or a respirator disposable in accordance with European standard EN 140, a filter with European standard EN 143. Wash exposed skin. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or label of the product People with known hypersensitivity to tiamulin should handle the product carefully. Special precautions for the disposal of unused drugs or materials derived from the use of these drugs Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
OVERDOSE (SYMPTOMS, EMERGENCY PROCEDURES, ANTIDOTES), IF NECESSARY Poultry : The LD50 for chickens is 1290 mg / kg bodyweight and for turkeys 840 mg / kg bodyweight.
Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
TIAMISOL Oral solution
MEDICINES
CONTRA-INDICATIONS
PAGE 15
VÉTÉRINAIRE
Powder for oral solution V29072011EAL
MEDICINES
TYLORAL
LA B O R AT O I R E
Poultry
COMPOSITION Tylosin (as tartrate)................................................. 100 000 000 IU Excipient ..................................................... Q.S. 1 sachet or 1 pot
PHARMACOLOGICAL PROPERTIES Pharmacotherapeutic group : Antibacterial macrolides. ATC-vet code : QJ01FA90. Pharmacodynamic properties Tylosin is an antibiotic with pKa of 7.1 structurally related to erythromycin. It is produced by a strain of Streptomyces fradiae. Tylosin is not very soluble in water, that’s the reason why we use tylosin tartrate which is soluble in water. Tylosin has the same antibiotic action mechanism as other macrolides, i.e. by fixing to the fraction 50S of ribosomes, resulting in inhibition of protein synthesis of susceptible micro-organisms. Tylosin has a dominant bacteriostatic activity. Tylosin has an antibiotic effect against the Gram-positive cocci (Staphylococci, Streptococci ) and the Gram-positive bacteria (Corynebacterium spp., Clostridium spp. Erysipelothrix, Bacillus anthracis, Actinomyces ), some Gram-negative strains (Haemophilus spp, Pasteurella
Calves : 20 000 IU of tylosin / kg of body weight, i.e. approximately 20 mg of tylosin / kg of body weight / twice daily for two weeks. The total quantity of powder contained in the container allows daily treatment of 50 calves. The intake of medicated water depends on the clinical condition of the animals. In order to obtain the correct dosage, the concentration of Tyloral has to be adjusted accordingly. Chickens : Prevention of necrotic enteritis: 10 000 to 20 000 IU of tylosin / kg of body weight, i.e. about 10 to 20 mg of tylosin / kg of body weight for 3 days. The total quantity of powder contained in the container is to be emptied in the tank of treatment for 1000 litres of drinking water. Turkeys : 50 000 to 100 000 IU of tylosin / kg of body weight, i.e., about 50 to 100 mg of tylosin / kg of body weight for 2 to 5 days. The total quantity of powder contained in the container is to be emptied in the tank of treatment for 200 litres of drinking water.
spp. Mannheimia spp.) and the mycoplasmas.
WITHDRAWAL PERIOD
Pharmacokinetic particulars Tylosin tartrate is well absorbed from the gastrointestinal tract. Tylosin is widely distributed in the body after absorption but does not achieve bloodbrain-barrier penetration. The volume of distribution of tylosin is about 1 to 2 L / kg in animals. It is excreted via urine and biliary as unchanged form. The time for half-life elimination of tylosin is about one to two hours depending on the species.
Meat and offal : - Calves : 10 days. - Poultry : 1 day. - Turkeys : 3 days. Eggs : zero day.
INDICATIONS Treatment of infections caused by germs susceptible to tylosin in poultry and calves. In poultry : Prevention and treatment of avian mycoplasmosis. In chickens : Prevention of necrotic enteritis caused by Clostridium perfringens. In turkeys : Prevention and treatment of infectious sinusitis. In calves : Prevention of pneumonia in calves due to mycoplasmas and Mannheimia haemolytica.
Shelf-life : 24 months. After dilution in drinking water : 24 hours. After dilution in milk or milk replacer : 2 hours. Keep the packaging carefully closed.
CATEGORY
ADMINISTRATION AND DOSAGE
Veterinary use. Prescription only. Adhere to prescribed doses.
Oral route. The total quantity of the 100 000 000 IU container (pot or sachet) should be diluted.
FRENCH MARKETING LICENCE (AMM) :
Poultry : Prevention and treatment of avian mycoplasmosis : 50 000 to 100 000 IU of tylosin / kg of body weight, i.e., about 50 to 100 mg of tylosin / kg of body weight for 3 days. The total quantity of powder contained in the container is to be emptied in the tank of treatment for 200 litres of drinking water.
PAGE 16
STORAGE
FR/V/7257757 2/2006
PACKAGING SACHET 100 000 000 UI POT 100 000 000 UI
GTIN 03661753033102 GTIN 03661753033119
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Turkey
Calves
Precautions for use in animals None.
ADVERSE REACTIONS Tylosin can induce diarrhea when administered orally in adult ruminants.
USE DURING PREGNANCY, LACTATION OR LAY Laboratory studies in animals have not produced any evidence of teratogenic or embryotoxicity effects or consequences on the fertility of animals.
Precautions to be taken by the person administering the veterinary medicinal product to animals Macrolides, such as tylosin, may cause hypersensitivity (allergy) following injection, inhalation, ingestion or contact with skin. Hypersensitivity to tylosin may lead to cross reactions to other macrolides and vice versa. Allergic reactions to these substances may occasionally be serious. In case of hypersensitivity, avoid contact with the product. If you develop symptoms following exposure, such as skin rash, you should seek medical advice. In case of swelling of the face, lips or eyes or difďŹ culty in breathing, seek urgent medical attention. Avoid inhaling dust and avoid contact with skin and eyes when handling the product. In case of accidental eye contact, ush the eyes with plenty of clean, running water. Wash hands after use of the product. Special precaution for the disposal of unused products or waste materials Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Poultry
Turkey
Calves
Powder for oral solution
PRECAUTIONS FOR USE
Do not use in case of hypersensitivity to tylosin or other macrolides.
TYLORAL
MEDICINES
CONTRAINDICATION
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PAGE 17
LA B O R AT O I R E
VÉTÉRINAIRE
Hydrosoluble powder making easier the elimination of toxins by liver and kidneys.
3034-1
DIETETICS
ANTITOX
INDICATIONS
DOSAGE
- Complement of anti-infectious treatment - Nephritis, hepatic disorder - Nutritional gastro-enteritis - Tonic for liver and kidneys
Use during 3 to 5 days. Poultry, rabbits : 1 g / Litre of drinking water. Other species : 1 g / 10 kg of live weight.
COMPOSITION PER KG Vitamin A ......................................10 000 000 UI Vitamin E ..............................................2 500 mg Vitamin K3 ...........................................1 000 mg Vitamin C .............................................2 500 mg Sodium benzoate .......................................500 g Ethanol-beta-amino Phosphoric acid ..........100 g
STORAGE Store in a cool and dry place and away from light.
PACKAGING 10 x 100 GR 1 Kg
PAGE 18
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LA B O R AT O I R E
VÉTÉRINAIRE
Nutritional supplement - Oral solution for all livestock animals V09062011EAL
DIETETICS
BICALPHOS
NUTRITIONAL AIMS
PRECAUTIONS FOR USE
Mineral supplement for all live stocks animals
Make sure feed is well balanced, body condition is good and animals are clean. Ensure a good feed transition. Must be recorded in the farm register.
•
Preparation for œstrus and reproduction.
•
Critical growth periods.
INSTRUCTIONS FOR USE
ADDITIVES PER KG
Distribute in drinking water or in feed, for 3 to 5 days at the following doses: Poultry, rabbits and young game birds (pheasants, partridges, quails) : 1 Litre per 1 000 Litres of drinking water.
Phosphorus (Phosphoric acid) ............99 500 mg Calcium (Calcium chloride) .................50 600 mg Sodium (Sodium chloride)...................15 200 mg Magnesium (Magnesium chloride) ......11 070 mg Manganese (Manganese chloride).........1 300 mg Iron(Iron chloride) .................................1420 mg Zinc (Zinc chloride) ..............................2 200 mg Copper (Copper chloride) .........................560 mg Excipient .............................................sqf 1 Litre
Large animals : • Adults : 1 mL per 10 kg of body weight per day (do not exceed 50 mL per animal per day). • Young animals : maximum 5 mL per animal and per day.
STORAGE Store in a cool and dry place and away from light.
PACKAGING 1 Litre can 5 Litre can
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PAGE 19
DIETETICS
B-MAX
LA B O R AT O I R E
VÉTÉRINAIRE
Liquid nutritional supplement V29072011EAL
for poultry and ruminants
NUTRITIONAL AIMS
INSTRUCTIONS FOR USE
Cutaneous protection and feather quality. Preparation for reproduction.
B-MAX is used for 3 to 5 days : - During periods of breeding, spawning, growth and moulting, for all species of poultry and game cage. - During periods of reproduction, growth and high production in all species. Pre-dilute 100 mL of B-MAX in a Litre of water, then use this mother solution on the rate of : - 1 mL per Litre of water for poultry - 5 mL per lamb or kid - 10 mL per sheep or adult goat - 10 mL per calf - 50 mL per bull calf or cattle
NUTRITIONAL INGREDIENTS Vitamins B1, B2, B5, B6, B12, PP, H, folic acid precursor.
COMPOSITION Guaranteed contents per 1 litre : Vitamin PP .................................................310 g Vitamin B5 .................................................150 g Vitamin B2 ...................................................32 g Vitamin B1 HCl .............................................19 g Vitamin B6 HCl ...............................................9 g Precurseur of folic acid .............................4,20 g Vitamin H .......................................................1 g Vitamin B12 ............................................100 mg
PRECAUTIONS FOR USE Make sure feed is well balanced, body condition is good, and animals are clean. Use a suitable dosage system. Store in a cool place. Degradation of vitamins is increased by the light and thermal shocks.
PACKAGING AND GLOBAL TRADE INTERNATIONAL NUMBER 100 mL BOTTLE GTIN 3661753003334 500 mL BOTTLE GTIN 3661753003341
PAGE 20
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LA B O R AT O I R E
VÉTÉRINAIRE
Nutritional liquid supplement for all species V29072011EAL
DIETETICS
CARNITOL - L
NUTRITIONAL AIMS
INSTRUCTIONS FOR USE
Weaning and critical growth periods. Hepatic steatosis syndrome risk reduction.
D-Sorbitol, Choline Chloride, plants and fruits Extracts (Artichoke, Boldo, Rosemary, Orthosiphon), L-carnitine, potassium sorbate, sodium citrate.
Distribute for 5 to 10 days in drinking water or feed at a dosage of : - Poultry, palmipeds : 1 mL per Litre of drinking water. - Calves : 20 mL per day. - Cattle : 50 to 100 mL per day, according to the weight. - Sheep and Goats : 20 mL per day. - Rabbits : 1 mL per Litre of drinking water.
COMPOSITION
PRECAUTIONS FOR USE
Guaranteed contents per 1 Litre : D-Sorbitol ..................................................... 200 g Choline (as chloride) ........................................ 28 g L-Carnitine ..................................................... 25 g
Ensure a good transition food, and distribute a ration low in energy. Use a suitable assay system. Products for animal feed. Store away from heat and light.
NUTRITIONAL INGREDIENTS
INDICATIONS AND ZOOTECHNICAL BENEFIT Throught its effects on intestinal transit and lipid intake, CARNITOL-L aids maximum use of feed in all species. It is recommended during periods of feed transition, fat overdeposit and peak in laying associated with the above-mentioned factors.
PACKAGING CAN 1 L CAN 5 L CAN 10 L
GTIN 3661753036707 GTIN 3661753036714 GTIN 3661753038794
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PAGE 21
LA B O R AT O I R E
VÉTÉRINAIRE
Nutritional supplement soluble powder V17092014ELO
DIETETICS
C-VET
COMPOSITION
PRECAUTION FOR USE
Vitamin C (Ascorbic acid).................................... 99 %
Ensure a good feed transition.
INDICATION Reduction of stress reactions. Critical growth stages.
INSTRUCTION FOR USE Distribute in drinking water or in feed for 3 to 7 days, at a dose of : • Poultry, rabbits, game birds : 0.25 to 1 g / L of water. • Sheep, goats, calves, foals : 4 g / 100 kg of body weight, by day. • Cattle, horses : 2 g / 100 kg of body weight, by day
PAGE 22
STORAGE Store in a cool and dry place and away from light.
PACKAGING Box : 1 kg Bag : 5 kg
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LA B O R AT O I R E
VÉTÉRINAIRE
Dietary nutritional supplement for all species Oral solution V03082011EAL
DIETETICS
LIVORAL
INDICATION Reduces risk of hepatic steatosis (all species). Pre force feeding (palmipeds).
NUTRITIONAL INGREDIENT D-Sorbitol, Choline chloride, Methionine, Potassium sorbate, sodium citrate.
COMPOSITION PER LITRE D-Sorbitol .............................................. 280 g Choline .................................................... 84 g Methionine ............................................. 7.5 g Ecipients ........................................... sq 1 Litre
INSTRUCTIONS FOR USE Distribute in drinking water or feed at the following doses : Rabbits, poultry : 1 to 2 mL per Litre of drinking water for 5 to 10 days. Cattle, horses, sheep, goats : 25 mL per 100 kg live weight per day for 3 to 5 days.
PRECAUTIONS FOR USE Ensure good feed transition. Use a suitable dosage system. Distribute a low energy feed.
SHELF-LIFE Store in a cool and dry place and away from light.
PACKAGING CAN 1 L CAN 5 L
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PAGE 23
DIETETICS
TONISELEN
LA B O R AT O I R E
VÉTÉRINAIRE
Nutritional Supplement V08032011EAL
all species
NUTRITIONAL AIMS
PRECAUTIONS FOR USE
Weaning, critical phases of growth. Preparing to estrus and reproduction (mammals, birds).
Use TONISELEN as a diet supplement during periods of high production, growth, peak spawning, lactation or in last part of pregnancy period.
Reflect selenium intake in the diet overall and not exceed 0.5 mg / kg of complete feed. Ensure a well-balanced nutrition, good bodies states and health. Ensure a good transition food. The distribution of this nutritional supplement must be noted on the Register Livestock
COMPOSITION
ANALYTICAL CONSTITUENTS
PROPERTIES
Vegetable oil.
INSTRUCTIONS FOR USE Distribute in drinking water or with the ration as : ! Poultry, rabbits : 1 mL per 10 kg of bodyweight or 1 Litre of drinking water for 5 days. ! Sheep, goats : 1 mL per 10 kg of bodyweight for 5 days. ! Calves, newborns : 3 mL at birth, repeated 15 days later. ! Calf rearing : 1 mL per Litre of drinking during 3 to 5 days. ! Dairy cows in dry off period : 100 mL per cow, 1 time per week for 4 weeks before calving.
Crude proteins ............................................ < 0.5% Crude fats ...................................................... 17% Humidity ......................................................... 72% Crude ash ...................................................... 0.3%
ADDITIVES PER KG Vitamin (3a700) Vitamin E .................................. 98,800 mg Trace element (E8) Selenium (as Sodium Selenite) ........... 445 mg
STORAGE Keep away from heat in its original packaging.
PACKAGING 1 Litre can 5 Litre can 10 Litre can
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Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
LA B O R AT O I R E
VÉTÉRINAIRE
Nutritional Supplement Oral solution V16032011EAL
DIETETICS
UCAVIT AD3E
INDICATIONS
INSTRUCTIONS FOR USE
Preparation for oestrus or reproduction. Critical phases of growth.
Before use, dilute as 10% with clean drinking water. Distribute in drinking water for 2 days. Renewable every 3 months. Can be used every month if the following doses are divided by three.
COMPOSITION Vitamin A ................................................... 100 MIU Vitamin D3 .................................................. 20 MIU Vitamin E ........................................................ 20 g Excipient water sq ............................................... 1 L
PRECAUTIONS FOR USE Ensure a good transition food. Make sure diet is well balanced, and animals are clean and healthy. Must be recorded in farm register.
Poultry and rabbits : ! Youth : 5 mL per Litre of drinking water per day. ! Adults : 1 mL per Litre of drinking water per day. Other species: ! Youth : - Calf : 20 mL per day for a calf - Lambs and kid : 5 mL per day for a lamb or kid ! Adult (intended for breeding) : - Lactating cow or milk cow : 100 mL per day for a dairy or lactating cow - Goat or sheep : 10 mL per animal, per day ! Adults (fattening): - Cattle: 50 mL per animal per day.
STORAGE Store in a cool and dry place and away from light.
PACKAGING 1 Litre can 5 Litre can
Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
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DIETETICS
VITAFLASH
LA B O R AT O I R E
VÉTÉRINAIRE
Hydrosoluble poly vitamins and amino acids powder
V03102011EAL
For all species
INDICATIONS All species : Stress, convalescence, growth, reproduction, anaemia and vitamins deficiencies.
INSTRUCTIONS FOR USE Use during 3 to 5 days as : – 1 g / Litre of drinking water – 1 g / 10 kg of live weight – 2 kg / ton of complete feed
COMPOSITION PER KG Vitamin A ......................................... 20 000 000 UI Vitamin D3 ........................................ 4 000 000 UI Vitamin E ................................................ 10 000 mg Vitamin B1................................................ 2 000 mg Vitamin B2................................................ 2 500 mg Vitamin B6................................................ 2 000 mg Vitamin B12..................................................... 5 mg Vitamin C .............................................. 10 000 mg Vitamin K3................................................ 2 000 mg Nicotinic acid .......................................... 10 000 mg Folic acid..................................................... 500 mg Methionine ............................................. 20 000 mg Lysine .................................................... 30 000 mg Calcium panthotenate ............................... 5 000 mg
STORAGE Keep in a cool and dry place.
PACKAGING 10 x 100 GR 1 Kg 5 Kg 25 Kg
PRECAUTIONS FOR USE Veterinary use.
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Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
DIETETICS
NOTES
Products and prices are subject to change without notice. For more information please contact Eurovets via Tel: +971 4 434 2436 or e-mail: orders@eurovetsworld.com
PAGE 27
ALL THE BEST BRANDS Eurovets is dedicated to providing your clinic with all your veterinary needs. We offer a comprehensive product range at highly competitive prices for small, large and equine animal practices including biological, diagnostics, nutritionals, medicines, equipment, consumables and more. Contact us today to place your order: Eurovets Veterinary Tel: +971 4 434 2436 E-mail: orders@eurovetsworld.com Address: Warehouse A6, Dubai Science Park, Dubailand, Al barsha South, United Arab Emirates, Dubai
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