Research Catalog
TARGETED PRODUCTS FOR CANCER RESEARCH
Primary Antibodies Detection Systems Antibody Microarrays Recombinant Proteins Other Complementary Reagents
2012
TECHNICAL CAPABILITIES
Recombinant Antibodies Mutation-Specific Antibodies Rabbit And Other Species Monoclonals
Ki-67 (SP6) Rabbit Monoclonal Human Tonsil
iNOS (SP126) Rabbit Monoclonal Human Lung
Actin-beta (SP124) Rabbit Monoclonal Human Placenta
F4/80 (SP115) Rabbit Monoclonal Mouse Liver
IKAROS (SP108)
FEATURING SP CLONES
Delivering Best-in-Class Rabbit Monoclonals since 2001.
Rabbit Monoclonal Human Tonsil
CD278/ICOS (SP98) Rabbit Monoclonal Human Reactive Lymph Node
FOXA1 (SP88) Rabbit Monoclonal Human Prostate
MESSAGE FROM SPRING BIOSCIENCE
Community of Cancer Researchers, Thank you for using our 2012 product catalog. Spring Bioscience is driven to build essential tools for cancer researchers so that tomorrow’s patients may benefit from today’s innovations. As a part of the Roche Diagnostics team and members of a society afflicted by cancer, we put tomorrow’s cancer patients at the center of our mission and are impassioned to enable researchers with high-quality tools for the analysis of cancer tissue. Spring was founded in 2001 by a team of scientists and achieved early success with their line of SP Clone rabbit monoclonal antibodies for clinical immunohistochemistry. This momentum was quickly noticed by Ventana Medical Systems who acquired the company in 2007 for its antibody development capabilities. Ventana Medical Systems was shortly thereafter acquired by Roche. Today, Spring serves an important role as an antibody center of excellence in Roche’s mission to deliver companion diagnostics. This is accomplished through not only developing antibodies destined for clinical assays through Ventana and other Roche affiliates but using our collective medical/market intelligence to serve the cancer research community. Our 2012 catalog highlights the dozens of new products we launched during 2011 and various other product updates including improved product utility and application images. By the time you are reading this catalog we will have also launched a new website at www. springbio.com which will contain a host of other product resources not available in the catalog. For example, hundreds of additional product images, customer feedback section, and much more. Thank you for the opportunity to assist you in your important and purposed work and if there is anything we can do to better serve you please let us know.
Sincerely,
Steve Reichling, General Manager, Spring Bioscience
TA B L E O F C O N T E N T S
Table of Contents Primary Antibody Products
11
Detection and Ancillary Products
109
Antibody Microarray Products
113
Recombinant Protein Products
115
Product Index
117
6
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
Urinary Bladder
√
Thyroid
√
Testis
√
√
Stomach
√
Soft Tissue
√
√
SM Intestine
√
Skin
√
Prostate
Liver
√
Pleura
Kidney
√
Placenta
Hematopoietic Cells
√
SP8
Pancreas
Endocrine
√
ALK/p80
Ovary
Colorectum
SP124
M308
Product Name
Osseous Tissue
Cervix
Actin-beta
Nervous Tissue
Cardiovascular
M424
Root Cat#
Lung
Clone
Breast
Rabbit Monoclonal Antibodies by Tissue Focus
√
√
√
√
√
√
√
√
√
√
M407
Androgen Receptor (AR)
SP107
√
M347
BAX
SP47
√
√
√ √
√
√
√
√
M366
BCL-2 alpha
SP66
√
√
√
√
√
√
M392
BOB-1
SP92
√
√
√
√
√
M391
C4d
SP91
M364
Cadherin-E/E-Cadherin
SP64
√
EC √
√
√
DC √
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M390
Cadherin-N/N-Cadherin
SP90
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M317
Calcitonin
SP17
M381
Calpain
SP81
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M382
Calpastatin
SP82
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M313
Calretinin
SP13
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M406
Carbonic Anhydrase 9 (CA-9)
SP106
√
M343
Caveolin-1
SP43
M307
CD3
SP7
TC
√
√
M335
CD4
SP35
TC
M319
CD5
SP19
TC
M394
CD7
SP94
TC
M316
CD8
SP16
TC
M367
CD10
SP67
√
M410
CD19
SP110
BC
M332
CD20
SP32
BC
M404
CD22
SP104
BC
M323
CD23
SP23
M338
CD31
SP38
M355
CD43
SP55
M337
CD44 Std
SP37
M318
CD79a
SP18
M419
CD99
SP119
M326
CD117/c-kit
SP26
M396
CD163
SP96
M398
CD278/ICOS
SP98
M380
CDK2
SP80
M354
CDX2
SP54
√
√ √
√
√
√
√
√
√
√
BC EC
EC
EC
EC
EC
EC
EC
EC
EC
√
√
√
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
√
√
√
√
√
√
√
√
√
√
√
√
√ √
√
√
√
√
√
EC
EC
TC √
√
√
√
√
√
BC √ √
√
√
√
√
√
√
√
√
√
√
√
TC
√
√
√ √
√ √
√
√
√
√
√
√
√
√ √
M303
c-erbB-2/HER-2
SP3
√
√
√
c-erbB-3/HER-3
SP71
√
√
√
√
√
M312
Chromogranin A
SP12
NE
NE
M344
c-Met
SP44
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M359
c-Met (Paired 1003)
SP59
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M358
c-Met (Phospho T1003)
SP58
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M321
COX-2
SP21
√
√
√
√
√
√
√
√
√
√
√
√
√
M383
c-TEN
SP83
√
√
√
√
√
√
√
√
√
√
√
√
√
M304
Cyclin D1
SP4
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
M331
DOG-1
SP31
M309
Epidermal Growth Factor Receptor (EGFR)
SP9
√
√
√
√
√
√
√
√
√
M384
Epidermal Growth Factor Receptor (EGFR)
SP84
√
√
√
√
√
√
√
√
M368
ERCC1
SP68
√
√
√
√
√
√
√
√
M301
Estrogen Receptor (ER)
SP1
√
√
√
NE
√ √
√
√
√
√
√
√
√
√
√
√
√
√
√
NE
NE
NE
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
PLC
PLC
PLC
PLC
PLC
PLC
PLC
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
NE
√ NE
NE
√
√
√
√
√
√
√
√
√
√
√
M371
√
√
√
√ √
√
√ √
√ √
√ √
PLC
PLC
PLC
√
√
M415
F4/80
SP115
K
M
M
M
M423
FLK-1 (mouse)
SP123
√
√
√
M √
√
M √
√
√
√
√
√
√
√
M √
√
√
√
√
√
√
√
√
√
M388
FOXA1
SP88
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
SP86
hENT1
SP120
M408
IKAROS
SP108
M405
J-chain
SP105
M327
Keratin 5
SP27
√
√
M387
Keratin 6
SP87
√
√
M352
Keratin 7
SP52
√
√
√
√
√
M402
Keratin 8
SP102
√
√
√
√
√
√
√
√
√
√
√
Urinary Bladder
√
Thyroid
√
√
Prostate
√
Ovary
√
√
Testis
Pancreas
Osseous Tissue
√ √
Stomach
Glypican-3
M420
√
Soft Tissue
M386
√
SM Intestine
√
Skin
SP78
Pleura
Glial Fibrillary Acidic Protein (GFAP)
Placenta
SP97
M378
Nervous Tissue
FOXP3
Lung
M397
Liver
Kidney
Hematopoietic Cells
Endocrine
Colorectum
Cervix
Clone
Cardiovascular
Product Name
Breast
Root Cat#
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
PC
M399
Keratin 10
SP99
√
√
√
√
M353
Keratin 14
SP53
√
√
√
√
M395
Keratin 17
SP95
√
√
√
M369
Keratin 18
SP69
√
√
√
√
M333
Keratin 20
SP33
√
√
M306
Ki-67
SP6
M351
LMO2
SP51
M385
MCM2
M374
PLC
√
PLC
PLC
PLC
PLC
PLC
SP85
√
√
√
√
√
Mesothelin
SP74
√
M346
MSH2
SP46
√
√
√
√
√
√
√
M393
MSH6
SP93
√
√
√
√
√
√
√
M414
MUM1/IRF4
SP114
M372
Myeloperoxidase (MPO)
SP72
√
M403
Nestin
SP103
ST
M426
Nitric Oxide SynthaseInducible (iNOS)
SP126
M363
p120 (catenin delta 1)
SP63
M305
p53
SP5
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√ √
√ √
√
√
√
√
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M
M
√
√
√
√
√
√
√
√
√
√
√ √
√
√
√
M √
√
√
ST
M √
√
M √
√
√
√
ST M √
√
√
√
√
√
√
√
√
√
√
M418
p57
SP118
M334
PAX-5
SP34
√
M362
PI3K p85
SP62
M315
PLAP
SP15
M302
Progesterone Receptor (PR)
SP2
√
√
√
√
√
√
√
√
√
√
√
M342
Progesterone Receptor (PR)
SP42
√
√
√
√
√
√
√
√
√
√
√
M329
PSMA
SP29
M350
S6 Ribosomal (Phospho S235/236)
SP50
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M345
S6 Ribosomal (Phospho S240/244)
SP45
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
ST
ST
ST
√ √
√
√
√
√ √
√
√ √
√
√
√
√
√
√
√
√
√
√
√
√ √
√
√
√
M422
SLIT2
SP122
M376
SOX-2
SP76
ST
√
√
M349
Stathmin
SP49
√
√
√
√
√
√
√
√
√
√
√
√
√
M379
Survivin
SP79
√
√
√
√
√
√
√
√
√
√
√
√
√
M311
Synaptophysin
SP11
NE
NE
NE
NE
M336
Syntaxin 1A
SP36
M370
Tau (Neuronal Marker)
SP70
√
√
√
√
√
√
√
√
√
√
√
√
√
M412
Thymidylate Synthase (TS)
SP112
√
√
√
√
√
√
√
√
√
√
√
√
√
M373
Uroplakin III
SP73
M328
Vascular Endothelial Growth Factor (VEGF)
SP28
M320
Vimentin
SP20
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M417
Vinculin
SP117
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
MC, EC
ST
√
√
√
√
√
√
√
√
√
√
√
√
ST
ST
√
√
√
√
√
√
√
√
√
√
NE
ST
NE
√
√
√
√
√
√
√
√ √
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√ √
ST √
NE
√
√ √
√
NE
√
√ √
ST
√
√ √
√
√ √
√
√
√
√
√
√
√ Indicates the organs or tumors derived from these organs express these markers using the information available in the public domain. Abbreviation: TC = T lymphocyte, BC = B lymphocyte, DC=dendritic cell, EC =endothelial cell, PC= plasma cell, NE = neuroendocrine cell, PLC =proliferating cell, ST=stem cell, M=macrophages, K=Kupffer cells, MC=Cardiac, skeletal, and smooth cells.
√
7
8
SP124
M308
ALK/p80
SP8
M407
Androgen Receptor (AR)
SP107
BAX
SP47
√
BCL-2 alpha
SP66
√
BOB-1
SP92
C4d
SP91
√ √
M364
Cadherin-E/E-Cadherin
SP64
√
M390
Cadherin-N/N-Cadherin
SP90
√
M317
Calcitonin
SP17
M381
Calpain
SP81
M382
Calpastatin
SP82
M313
Calretinin
SP13
M406
Carbonic Anhydrase 9 (CA-9)
SP106
√ √ √ √ √
M343
Caveolin-1
SP43
M307
CD3
SP7
√
M335
CD4
SP35
√
M319
CD5
SP19
√
M394
CD7
SP94
M316
CD8
SP16
M367
CD10
SP67
M410
CD19
SP110
√
M332
CD20
SP32
√
M404
CD22
SP104
√
M323
CD23
SP23
M338
CD31
SP38
M355
CD43
SP55
M337
CD44 Std
SP37
M318
CD79a
SP18
M419
CD99
SP119
M326
CD117/c-kit
SP26
M396
CD163
SP96
M398
CD278/ICOS
SP98
M380
CDK2
SP80
√
√ √ √
√ √ √ √ √ √ √ √ √ √
M354
CDX2
SP54
M303
c-erbB-2/HER-2
SP3
√
√
M371
c-erbB-3/HER-3
SP71
√
M312
Chromogranin A
SP12
M344
c-Met
SP44
√
M359
c-Met (Paired 1003)
SP59
√
M358
c-Met (phospho T1003)
SP58
√
M321
COX-2
SP21
M383
c-TEN
SP83
√
√ √
M304
Cyclin D1
SP4
M331
DOG-1
SP31
M309
Epidermal Growth Factor Receptor (EGFR)
SP9
√
M384
Epidermal Growth Factor Receptor (EGFR)
SP84
√
M368
ERCC1
SP68
M301
Estrogen Receptor (ER)
SP1
M415
F4/80
SP115
√ √
√ √ √
Translational Control
Transcriptional Regulators
Synthesis and Degradation
Steroid Receptors
Stem Cell
Signal Transduction
Oncogenesis
Nitrogen Metabolism
Neuroscience
Lymphocyte Signaling
Immunoglobulin
Hormones
Homeodomain Proteins
Hematopoiesis
Enzymes
EGFR Family
DNA Synthesis
DNA Replication and Repair
Cytoskeletal Proteins
Complement
Cell Junctions
Cell Cycle
Cell Adhesion
√ √
M347 M392
Cancer Markers
√
M366 M391
B Cell Markers
Clone
Actin-beta
Apoptosis
Product Name
M424
Angiogenesis
Root Cat#
AKT/PKB Signaling
Rabbit Monoclonal Antibodies by Major Research Interest
SP123
M388
FOXA1
SP88
M397
FOXP3
SP97
M378
Glial Fibrillary Acidic Protein (GFAP)
SP78
M386
Glypican-3
SP86
M420
hENT1
SP120
M408
IKAROS
SP108
M405
J-chain
SP105
M327
Keratin 5
SP27
M387
Keratin 6
SP87 √ √
M395
Keratin 17
SP95
Translational Control
Transcriptional Regulators
Synthesis and Degradation
Steroid Receptors
Stem Cell
Signal Transduction
Oncogenesis
Nitrogen Metabolism
Neuroscience
Lymphocyte Signaling
Immunoglobulin
Hormones
√ √
SP52 SP99
Homeodomain Proteins
√ √
SP102 SP53
Hematopoiesis
√ √
Keratin 7 Keratin 10
Enzymes
√ √
Keratin 8 Keratin 14
EGFR Family
√
M352 M399
DNA Synthesis
√
M402 M353
DNA Replication and Repair
Cytoskeletal Proteins
Complement
Cell Junctions
Cell Cycle
Cell Adhesion
Cancer Markers
B Cell Markers
Apoptosis
Clone
FLK-1 (mouse)
Angiogenesis
Product Name
M423
AKT/PKB Signaling
Root Cat#
√
√ √
M369
Keratin 18
SP69
√
M333
Keratin 20
SP33
√
M306
Ki-67
SP6
M351
LMO2
SP51
M385
MCM2
SP85
√ √ √
M374
Mesothelin
SP74
M346
MSH2
SP46
√ √
M393
MSH6
SP93
√
M414
MUM1/IRF4
SP114
M372
Myeloperoxidase (MPO)
SP72
√ √
M403
Nestin
SP103
M426
Nitric Oxide SynthaseInducible (iNOS)
SP126
M363
p120 (catenin delta 1)
SP63
M305
p53
SP5
√
M418
p57
SP118
√
M334
PAX-5
SP34
M362
PI3k p85
SP62
M315
PLAP
SP15
√
M302
Progesterone Receptor (PR)
SP2
√
M342
Progesterone Receptor (PR)
SP42
M329
PSMA
SP29
M350
S6 Ribosomal (phospho S235/236)
SP50
√
M345
S6 Ribosomal (phospho S240/244)
SP45
√
M422
SLIT2
SP122
M376
SOX-2
SP76
M349
Stathmin
SP49
M379
Survivin
SP79
M311
Synaptophysin
SP11
M336
Syntaxin 1A
SP36
M370
Tau (Neuronal Marker)
SP70
M412
Thymidylate Synthase (TS)
SP112
M373
Uroplakin III
SP73
M328
Vascular Endothelial Growth Factor (VEGF)
SP28
M320
Vimentin
SP20
M417
Vinculin
SP117
√ √ √
√ √
√ √
√ √ √ √ √ √ √ √ √ √ √ √
9
FEATURING SP CLONES
Rabbit Monoclonal
Delivering Best-in-Class Rabbit Monoclonals since 2001.
CD19
Rabbit Monoclonal
SP = Spring Bioscience Corporation While you may not be familiar with Spring Bioscience Corporation, you are probably quite familiar with rabbit monoclonal “SP� clones. All SP antibody clone products were CD19 Rabbit Monoclonal designed and manufactured by Spring Bioscience. It all started with SP1, the now gold standard Estrogen Receptor marker. SP clones continue to emerge as best-in-class immunohistochemistry markers for their high affinity, sensitivity, and specificity.
10
Terms and Conditions Spring Bioscience products are for research use only. They are not for use in diagnostic procedures. Spring Bioscience strives to provide complete and accurate information; however, Spring Bioscience and its business associates assume no liability for any reliance on any of the information provided. Furthermore, Spring Bioscience assumes no liability for any omissions. It is the sole responsibility of researchers to independently validate the information and proper use of any products. Spring Bioscience reserves the right to make any changes, additions, and/or deletions to its product information at anytime without notice.
PRIMARY ANTIBODY PRODUCTS
Spring Bioscience develops and manufactures a wide range of products primarily specialized for IHC. Primary Antibodies – specifically characterized for use in IHC, featuring: • Clean and intense staining • Lower pre-treatment requirement • Robust performance for FFPE tissue • Improved reproducibility • Accepted by industry leaders Available in 0.1ml, 0.5ml and 1.0ml concentrated sizes as well as a 7ml ready-to-use configuration. Antibody product technologies include: • Rabbit Monoclonal (SP clones) • Mouse Monoclonal (SPM clones) • Rabbit Polyclonal
11
14-3-3 beta Rabbit Polyclonal
Actin-beta Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E4550
0.1ml
Concentrate
Immunogen: N-terminus of human beta actin.
Concentrate
Immunogen: Synthetic peptide from N-terminus of human 14-3-3 beta.
E4552
0.5ml
Concentrate
Concentrate
Application: IHC-P, WB
Application: IHC-P
1.0ml
E4554
1.0ml
Concentrate
7.0ml
Ready-to-use
Species Reactivity: Human*
E4551
7.0ml
Ready-to-use
Species Reactivity: Human*
Catalog No.
Size
Format
E2920
0.1ml
Concentrate
E2922
0.5ml
E2924 E2921
Isotype: Rabbit IgG
Clone: N/A
Isotype: Rabbit IgG Control Tissue: Leiomyoma, Skin
Control Tissue: Brain, Prostate Carcinoma, Liver Carcinoma
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm Control Lysate: Jurkat Molecular Weight: 30 kDa Human Leiomyoma stained with anti-Actin-beta antibody E455
Human Brain stained with anti-14-3-3 beta antibody E292
Product Description: At least 7 mammalian isoforms comprise the 14-3-3 family of signaling intermediates. 14-3-3 molecules are highly conserved, expressed in a broad range of tissues and cell types and were first discovered as a series of highly abundant proteins in brain tissue. There is increasing evidence that 14-3-3 proteins are critical to cell transformation and mitotic signaling.
Product Description: The two major cytoskeletal proteins implicated in cell motility are actin and myosin. There are three α-actins (skeletal, cardiac, and smooth muscle), one β-actin (β-nonmuscle), and two γ-actins (γ-smooth muscle and γ-nonmuscle). Antibody to β-actin provides a specific and useful tool in studying the intracellular distribution of β-actin and the static and dynamic aspects of the cytoskeleton.
14-3-3 zeta Rabbit Polyclonal
Actin-Skeletal Muscle Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E3880
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human 14-3-3 zeta.
E3882
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P, WB
E3884
1.0ml
Concentrate
7.0ml
Ready-to-use
Species Reactivity: Human*
E3881
7.0ml
Ready-to-use
Catalog No.
Size
Format
E12600
0.1ml
Concentrate
E12602
0.5ml
E12604 E12601
Clone: N/A Immunogen: Synthetic peptide derived from N-terminus of human alpha skeletal muscle isoform of actin. Application: IHC-P Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Tonsil
Control Tissue: Skeletal Muscle
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Control Lysate: 293T Molecular Weight: 28 kDa
Human Skeletal Muscle stained with anti-Actin-Skeletal Muscle antibody E388
Human Breast Carcinoma stained with anti-14-3-3 zeta antibody E1260
Product Description: 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation and activation/repression of enzyme activity.
Product Description: This antibody reacts with sarcomeric actins of normal tissues and neoplasms derived from such tissues (i.e. rhabdomyosarcomas).
Actin-beta Rabbit Monoclonal
Actin-Skeletal Muscle Mouse Monoclonal Clone: 5C5.F8.C7
Clone: SP124
Catalog No.
Size
Format
E16650
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide near the N-terminus of human actin-beta protein.
E16652
0.5ml
Concentrate
Immunogen: N-terminus decapeptide of alpha skeletal muscle isoform of actin.
1.0ml
Concentrate
Application: IHC-P, WB
E16654
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E16651
7.0ml
Ready-to-use
Catalog No.
Size
Format
M4240
0.1ml
Concentrate
M4242
0.5ml
M4244 M4241
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Mouse IgM
Control Tissue: Placenta
Control Tissue: Skeletal Muscle
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Control Lysate: Raji Molecular Weight: 42 kDa Human Placenta stained with anti-Actin-beta antibody M424
Product Description: Beta-actin is a nonmuscle cytoskeletal protein in all human cell types and is involved in cell motility, structure, and integrity. There are six different actin isoforms in human. Antibody to beta-actin provides a specific and useful tool in studying the intracellular distribution of beta-actin and the static and dynamic aspects of the cytoskeleton.
12
Human Skeletal Muscle stained with anti-Actin-Skeletal Muscle antibody E1665
Product Description: This antibody reacts with sarcomeric actins of normal tissues and neoplasms derived from such tissues (i.e. rhabdomyosarcomas).
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Actin-Smooth Muscle Rabbit Polyclonal
Adrenocorticotrophic Hormone (ACTH) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3490
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from N-terminus of human alpha smooth muscle isoform of actin.
E3492
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human ACTH.
1.0ml
Concentrate
Application: IHC-P
E3494
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E3491
7.0ml
Ready-to-use
Catalog No.
Size
Format
E2460
0.1ml
Concentrate
E2462
0.5ml
E2464 E2461
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Leiomyoma, Smooth Muscle in Small Intestine
Control Tissue: Pituitary Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Smooth Muscle in Small Intestine stained with anti-Actin-Smooth Muscle antibody E246
Human Pituitary stained with anti-Adrenocorticotrophic Hormone (ACTH) antibody E349
Product Description: This antibody stains smooth muscle cells in vessel walls, gut wall, and myometrium. Myoepithelial cells in breast and salivary gland are also stained. It reacts with tumors arising from smooth muscles and myoepithelial cells. Actin from fibroblasts (beta- and gamma-cytoplasmic), striated muscle (alpha-sarcomeric), and myocardium (alpha-myocardial) are not stained.
Product Description: ACTH labels corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas.
Actin-Smooth Muscle Mouse Monoclonal
Adrenocorticotrophic Hormone (ACTH) Mouse Monoclonal
Clone: 1A4
Catalog No.
Size
Format
E16450
0.1ml
Concentrate
Immunogen: ACTH synthetic peptide.
Concentrate
Immunogen: Synthetic peptide from N-terminus of human alpha smooth muscle isoform of actin.
E16452
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
E16454
1.0ml
Concentrate
7.0ml
Ready-to-use
Species Reactivity: Human*
E16451
7.0ml
Ready-to-use
Species Reactivity: Human*
Catalog No.
Size
Format
E14340
0.1ml
Concentrate
E14342
0.5ml
E14344 E14341
Isotype: Mouse IgG1/k
Clone: SPM501
Isotype: Mouse IgG1 Control Tissue: Pituitary
Control Tissue: Leiomyoma, Smooth Muscle
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Smooth Muscle stained with anti-Actin-Smooth Muscle antibody E1434
Human Pituitary stained with anti-Adrenocorticotrophic Hormone (ACTH) antibody E1645
Product Description: This antibody stains smooth muscle cells in vessel walls, gut wall, and myometrium. Myoepithelial cells in breast and salivary gland are also stained. It reacts with tumors arising from smooth muscles and myoepithelial cells. Actin from fibroblasts (beta- and gamma-cytoplasmic), striated muscle (alpha-sarcomeric), and myocardium (alpha-myocardial) are not stained.
Product Description: ACTH labels corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas.
Adenomatous Polyposis Coli (APC) Rabbit Polyclonal
AKT-1/AKT-2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E10840
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human APC protein.
E10842
0.5ml
Concentrate
Immunogen: Synthetic peptide from N-terminus of human AKT-1.
1.0ml
Concentrate
Application: IHC-P
E10844
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E10841
7.0ml
Ready-to-use
Catalog No.
Size
Format
E4080
0.1ml
Concentrate
E4082
0.5ml
E4084 E4081
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Colon Carcinoma
Control Tissue: Lung Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Colon Carcinoma stained with anti-Adenomatous Polyposis Coli (APC) antibody E408
Human Lung Carcinoma stained with anti-AKT-1/AKT-2 antibody E1084
Product Description: APC is associated with structural components of intracellular junctions, including conductin, and it competes with E-cadherin for binding to specific internal regions of both β- and γ-catenin. Like APC, APC2 contains SAMP domains, which are required for conductin binding. Both APC and APC2 regulate the formation of active β-catenin-Tcf complexes.
Product Description: Two serine/threonine kinases, designated AKT-1 and AKT-2 (alternatively referred to as PKB or RacPK), exhibit sequence homology with the protein kinase A and C families and are encoded by the c-AKT proto-oncogene. AKT-1 and AKT-2 contain a Pleckstrin homology (PH) domain and are activated by PDGF stimulation. This activation is dependent on PDGFR-beta tyrosine residues 740 and 751, which bind the 85kDa subunit of the phosphatidylinositol 3-kinase (PI-3 kinase) complex.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
13
AKT-1/PKB (Phospho S473) Rabbit Polyclonal Catalog No.
Size
Format
E13450
0.1ml
Concentrate
E13452
0.5ml
Concentrate
E13454
1.0ml
Concentrate
E13451
7.0ml
Ready-to-use
alpha Fetoprotein (AFP) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide derived from the region of human AKT-1 that contains phosphorylated site of serine 473.
E2950
0.1ml
Concentrate
E2952
0.5ml
Concentrate
Immunogen: Human alpha-fetoprotein purified from human cord serum.
E2954
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P, WB
E2951
7.0ml
Ready-to-use
Species Reactivity: Human*
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG Control Tissue: Breast Carcinoma
Control Tissue: Human alpha-fetoprotein purified from human cord serum.
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Cytoplasm Control Lysate: HepG2 Molecular Weight: 70 kDa
Human Breast Carcinoma stained with anti-AKT-1/PKB (Phospho S473) antibody E1345
Human Fetal Liver stained with anti-alpha Fetoprotein (AFP) antibody E295
Product Description: The AKT-1 serine threonine protein kinase is catalytically inactive in serum starved primary and immortalized fibroblasts and activated by platelet derived growth factor. The activation is rapid and specific. Survival factors can suppress apoptosis in a transcription independent manner by activating AKT-1, which then phosphorylates and inactivates components of the apoptotic machinery. This antibody is specific to the phosphorylated form of AKT-1.
Product Description: AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been identified in hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.
ALK/p80 Rabbit Monoclonal
alpha-1-Antichymotrypsin Rabbit Polyclonal
Catalog No.
Size
Format
M3080
0.1ml
Concentrate
M3082
0.5ml
Concentrate
M3084
1.0ml
Concentrate
M3081
7.0ml
Ready-to-use
Clone: SP8 Immunogen: Recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript. Application: IHC-P Species Reactivity: Human*
Clone: N/A
Catalog No.
Size
Format
E3450
0.1ml
Concentrate
Immunogen: Purified human alpha-1-antichymotrypsin.
E3452
0.5ml
Concentrate
Application: IHC-P
E3454
1.0ml
Concentrate
E3451
7.0ml
Ready-to-use
Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Tonsil
Isotype: Rabbit IgG
Cellular Localization: Cytoplasm
Control Tissue: Anaplastic Lymphoma Cellular Localization: Cytoplasm, Nucleus
Human Anaplastic Lymphoma stained with anti-ALK/p80 antibody M308
Human Tonsil stained with anti-alpha-1-Antichymotrypsin antibody E345
Product Description: This antibody recognizes a human p80 protein, identified as a hybrid of the anaplastic lymphoma kinase (ALK) gene and the nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in a third of large cell lymphomas. This antibody can be used to detect p80 in these lymphomas and may also be used to detect a subtype of large B cell lymphoma, which expresses the full-length ALK protein.
Product Description: Alpha-1-Antichymotrypsin (Alpha 1-ACT) is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1-ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer’s disease (AD) and in normal aged human and monkey brain. Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation.
ALK/p80 Rabbit Polyclonal
alpha-1-Antitrypsin Rabbit Polyclonal
Catalog No.
Size
Format
E1090
0.1ml
Concentrate
E1092
0.5ml
Concentrate
E1094
1.0ml
Concentrate
E1091
7.0ml
Ready-to-use
Clone: N/A Immunogen: Recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C- terminus of the NPM-ALK transcript. Application: IHC-P Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Anaplastic Lymphoma
Clone: 5C5.F8.C7
Catalog No.
Size
Format
E3440
0.1ml
Concentrate
Immunogen: Purified human alpha-1-antitrypsin.
E3442
0.5ml
Concentrate
Application: IHC-P
E3444
1.0ml
Concentrate
E3441
7.0ml
Ready-to-use
Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Tonsil Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Nucleus
Human Anaplastic Lymphoma stained with anti-ALK/p80 antibody E109
Product Description: This antibody recognizes a human p80 protein, identified as a hybrid of the anaplastic lymphoma kinase (ALK) gene and the nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in a third of large cell lymphomas. This antibody can be used to detect p80 in these lymphomas and may also be used to detect a subtype of large B cell lymphoma, which expresses the full-length ALK protein.
14
Human Tonsil stained with anti-alpha-1-Antitrypsin antibody E344
Product Description: Alpha-1-antitrypsin (alpha-1-AT) exists in a number of genetic variants. MM variant is the most common. Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema).
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Amylin Peptide Rabbit Polyclonal
Androgen Receptor (AR) Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4070
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human amylin protein.
M4072
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from near N-terminus of human AR.
1.0ml
Concentrate
Application: IHC-P
M4074
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M4071
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3400
0.1ml
Concentrate
E3402
0.5ml
E3404 E3401
Clone: SP107
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Pancreas
Control Tissue: Prostate Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus
Human Pancreas stained with anti-Amylin Peptide antibody E340
Human Prostate Carcinoma stained with anti-Androgen Receptor (AR) antibody M407
Product Description: Amylin is a pancreatic islet peptide with a role in the maintenance of glucose homoeostasis. It is predominantly found in the beta cells of the pancreas and to a lesser extent in the gastrointestinal tract and nervous system. This antibody may prove of value in studies to determine the level of staining for amylin in normal and diabetic pancreas and pancreatic carcinoma.
Product Description: The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. The expression of AR is reportedly inversely correlated with histologic grade, i.e., well differentiated prostate tumors show higher expression than the poorly differentiated tumors.
Amyloid Precursor Protein (APP) Rabbit Polyclonal
Androgen Receptor (AR) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2720
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human APP.
E2722
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from near N-terminus of human AR.
1.0ml
Concentrate
Application: IHC-P
E2724
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
E2721
7.0ml
Ready-to-use
Catalog No.
Size
Format
E2650
0.1ml
Concentrate
E2652
0.5ml
E2654 E2651
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Alzheimer’s Brain
Control Tissue: Prostate Carcinoma
Cellular Localization: Cytoplasm, Extracellular Matrix
Cellular Localization: Nucleus Control Lysate: LnCap Molecular Weight: 110 kDa
Human Alzheimer’s Brain stained with anti-Amyloid Precursor Protein (APP) antibody E265
Human Prostate Carcinoma stained with anti-Androgen Receptor (AR) antibody E272
Product Description: This antibody recognizes APP (β-APP770), MW 110kDa. Predicted to recognize β-APP695 and β-APP751. Amyloid precursor protein (APP) and APP-like proteins are transmembrane glycoproteins with a similar modular domain structure.
Product Description: The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. The expression of AR is reportedly inversely correlated with histologic grade, i.e., well differentiated prostate tumors show higher expression than the poorly differentiated tumors.
Amyloid-beta/Amyloid A4 Rabbit Polyclonal
Annexin I Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E14030
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from N-terminus of human amyloid beta.
E14032
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human annexin I.
1.0ml
Concentrate
Application: IHC-P
E14034
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E14031
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3530
0.1ml
Concentrate
E3532
0.5ml
E3534 E3531
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Alzheimer’s Brain
Control Tissue: Placenta
Cellular Localization: Transmembrane, Extracellular Matrix
Cellular Localization: Membrane
Human Alzheimer’s Brain stained with anti-Amyloid-beta/Amyloid A4 antibody E353
Human Placenta stained with anti-Annexin I antibody E1403
Product Description: Amyloid beta-protein/amyloid A4 or amyloid beta-peptide is derived from the amyloid betaprecursor protein. Beta amyloid is an extracellular filamentous protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles in Alzheimer’s brain. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type) and in the Guam Parkinson-Dementia complex.
Product Description: Annexin family members have been implicated as regulators of such diverse processes as ion flux, endocytosis and exocytosis and cellular adhesion. Annexin A1, a gene related to phagocytosis, was found to be one of the most highly upregulated genes in hairy cell leukemia.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
15
Annexin VI Rabbit Polyclonal
BAX Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3470
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human Annexin VI.
M3472
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human BAX protein.
1.0ml
Concentrate
Application: IHC-P, WB
M3474
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M3471
7.0ml
Ready-to-use
Catalog No.
Size
Format
E12380
0.1ml
Concentrate
E12382
0.5ml
E12384 E12381
Clone: SP47
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Liver, Tonsil
Control Tissue: Breast, Colon
Cellular Localization: Membrane
Cellular Localization: Cytoplasm, Membrane
Control Lysate: 293T Molecular Weight: 75 kDa Human Liver stained with anti-Annexin VI antibody E1238
Human Breast stained with anti-BAX antibody M347
Product Description: Annexin family members have been implicated as regulators of such diverse processes as ion flux, endocytosis and exocytosis and cellular adhesion. Annexin VI is positively regulated by calcium. It contains 8 annexin repeats and it binds actin filament and lipids. Annexin VI has been localized to stress fibers, membrane ruffles, and microspikes.
Product Description: BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
Apoptosis Protease Activating Factor 1 (APAF-1) Rabbit Polyclonal
BAX Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17990
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human APAF-1.
E17992
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human BAX protein.
1.0ml
Concentrate
Application: IHC-P
E17994
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E17991
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3950
0.1ml
Concentrate
E3952
0.5ml
E3954 E3951
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Testis
Control Tissue: Breast, Colon
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Human Testis stained with anti-Apoptosis Protease Activating Factor 1 (APAF-1) antibody E395
Human Breast stained with anti-BAX antibody E1799
Product Description: APAF-1 is a cytosolic protein that rests in a latent state until bound by cytochrome c (APAF-2). The resulting APAF-1/cytochrome c complex associates with the zymogen form of caspase-9 (APAF-3) in the presence of dATP or ATP, promoting the autocatalytic activation of caspase-9. This antibody can be useful in studies of apoptotic cell death.
Product Description: BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
BAK Rabbit Polyclonal
BCL-2 alpha** Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3660
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human BAK.
M3662
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human BCL-2 alpha protein.
1.0ml
Concentrate
Application: IHC-P
M3664
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M3661
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3320
0.1ml
Concentrate
E3322
0.5ml
E3324 E3321
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Human Tonsil stained with anti-BAK antibody E332
Human Tonsil stained with anti-BCL-2 alpha antibody M366
Product Description: BAK or BCL-2-homologous antagonist is a member of the BCL-2 family of homologous proteins which function in the regulation of apoptosis. The BCL-2 related proteins interact with one another through the formation of homo- and heterodimers. BAK has been localized by immunohistochemistry to the cytosol of cells and stains in a punctate pattern characteristic of other BCL-2 family proteins, which have been localized to intracellular organelles.
16
Clone: SP66
Product Description: Expression of BCL-2 alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies BCL-2 alpha Rabbit Polyclonal
BCL-10 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E19030
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human BCL-2 alpha protein.
E19032
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human BCL-10.
1.0ml
Concentrate
Application: IHC-P
E19034
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E19031
7.0ml
Ready-to-use
Catalog No.
Size
Format
E17980
0.1ml
Concentrate
E17982
0.5ml
E17984 E17981
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm
Human Tonsil stained with anti-BCL-2 alpha antibody E1798
Human Tonsil stained with anti-BCL-10 antibody E1903
Product Description: Expression of BCL-2 alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative.
Product Description: BCL-10/CIPER/CLAP/mE10 is expressed in many human and murine tissues. It contains a CARD (caspase recruiting domain) domain and is involved in activation of caspase 9 to induce apoptosis. It is a cellular homolog of equine herpesvirus 2 E-10. It is known to induce activation of JNK, p38 and NF-kappaB. Mutations in BCL-10 are observed in many B and T cell lymphomas implicating its role in pathogenesis of human cancer.
BCL-6 Rabbit Polyclonal
BCL-10 Mouse Monoclonal Clone: N/A
Catalog No.
Size
Format
E16760
0.1ml
Concentrate
Immunogen: Recombinant BCL-10 protein.
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human BCL-6 protein.
E16762
0.5ml
Concentrate
Concentrate
Application: IHC-P
Application: IHC-P
1.0ml
E16764
1.0ml
Concentrate
7.0ml
Ready-to-use
Species Reactivity: Human*
E16761
7.0ml
Ready-to-use
Species Reactivity: Human*
Catalog No.
Size
Format
E14090
0.1ml
Concentrate
E14092
0.5ml
E14094 E14091
Isotype: Rabbit IgG
Clone: SPM520
Isotype: Mouse IgG1 Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Nucleus
Human Tonsil stained with anti-BCL-6 antibody E1409
Human Tonsil stained with anti-BCL-10 antibody E1676
Product Description: BCL-6 proto-oncogene product is mainly expressed in normal germinal center B cells and related lymphomas. BCL-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin’s lymphomas and BCL-6 rearrangements have been detected in diffuse large B cell lymphomas. BCL-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt lymphomas and in nodular, lymphocyte predominant Hodgkin’s disease.
Product Description: BCL-10/CIPER/CLAP/mE10 is expressed in many human and murine tissues. It contains a CARD (caspase recruiting domain) domain and is involved in activation of caspase 9 to induce apoptosis. It is a cellular homolog of equine herpesvirus 2 E-10. It is known to induce activation of JNK, p38 and NF-kappaB. Mutations in BCL-10 are observed in many B and T cell lymphomas implicating its role in pathogenesis of human cancer.
BCL-10 Rabbit Polyclonal
BCL-X Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E3370
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide near the N-terminus of human BCL-10 protein.
E3372
0.5ml
Concentrate
Immunogen: Synthetic protein derived from near N-terminus of the human BCL-X protein.
1.0ml
Concentrate
Application: IHC-P
E3374
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
E3371
7.0ml
Ready-to-use
Catalog No.
Size
Format
E19240
0.1ml
Concentrate
E19242
0.5ml
E19244 E19241
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Hodgkin’s Lymphoma
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Cytoplasm, Membrane, Nucleus Control Lysate: 293T Molecular Weight: 27 kDa
Human Tonsil stained with anti-BCL-10 antibody E1924
Product Description: BCL-10 is a cytoplasmic protein expressed at different levels in most normal human cells and translocates into the nucleus of MALT lymphoma, especially in those with translocation (1;14)(p22;q32). BCL-10 and MALT-1 protein form a complex in MALT lymphoma. They are thought to synergize in the activation of NF-kappaB, and may contribute to the same pathogenic process that leads to malignancy. Mutations in BCL-10 are observed in some B and T cell lymphomas.
Human Hodgkin’s Lymphoma stained with anti-BCL-X antibody E337
Product Description: BCL-X is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. BCL-X has two isoforms, BCL-XL (long) a 241 amino acid protein and BCL-XS (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the BCL-2 family.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
17
BCL-XL Rabbit Polyclonal
Bnip3L Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
E16840
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human BCL-X protein.
E16842
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human BNIP3L protein.
1.0ml
Concentrate
Application: IHC-P, WB
E16844
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E16841
7.0ml
Ready-to-use
Catalog No.
Size
Format
E4200
0.1ml
Concentrate
E4202
0.5ml
E4204 E4201
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma, Hodgkin’s Lymphoma
Control Tissue: Breast Carcinoma Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane, Nucleus Control Lysate: 293T Molecular Weight: 27 kDa
Human Breast Carcinoma stained with anti-Bnip3L antibody E1684
Human Colon Carcinoma stained with anti-BCL-XL antibody E420
Product Description: BCL-X is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. BCL-X has two isoforms, BCL-XL (long) a 241 amino acid protein and BCL-XS (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the BCL-2 family.
Product Description: BCL2/adenovirus E1B 19kDa protein-interacting protein 3-like (Bnip3L) is a protein encoded by the BNIP3L gene in humans. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes suppression by BCL-2 and BCL-XL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues. Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.
BCL-XL Mouse Monoclonal
BOB-1 Rabbit Monoclonal Clone: SP92
Clone: 7D9
Catalog No.
Size
Format
M3920
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of mouse BCL-XL protein.
M3922
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human BOB-1 protein.
1.0ml
Concentrate
Application: IHC-P
M3924
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
M3921
7.0ml
Ready-to-use
Catalog No.
Size
Format
E16660
0.1ml
Concentrate
E16662
0.5ml
E16664 E16661
Species Reactivity: Human*
Isotype: Mouse IgG2a
Isotype: Rabbit IgG
Control Tissue: Hodgkin’s Lymphoma
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Membrane, Nucleus
Cellular Localization: Nucleus Control Lysate: Ramos Molecular Weight: 35 kDa Human Tonsil stained with anti-BOB-1 antibody M392
Human Hodgkin’s Lymphoma stained with anti-BCL-XL antibody E1666
Product Description: BCL-X is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. BCL-X has two isoforms, BCL-XL (long) a 241 amino acid protein and BCL-XS (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the BCL-2 family.
Product Description: B cell Oct binding protein 1 (BOB-1), is a transcription factor that is required for germinal center formation and immunoglobulin production. BOB-1 is expressed at high levels in spleen and peripheral blood leukocytes and represents an OCT co-factor capable of conferring cell specific activation of OCT-1 and OCT-2.
BIM/BOD Rabbit Polyclonal
BOB-1 Rabbit Polyclonal Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E16670
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human BIM.
E16672
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human BOB-1.
1.0ml
Concentrate
Application: IHC-P
E16674
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
E16671
7.0ml
Ready-to-use
Catalog No.
Size
Format
E4360
0.1ml
Concentrate
E4362
0.5ml
E4364 E4361
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta
Control Tissue: Tonsil
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus Control Lysate: Ramos Molecular Weight: 35 kDa
Human Placenta stained with anti-BIM/BOD antibody E436
Human Tonsil stained with anti-BOB-1 antibody E1667
Product Description: BIM/BOD (BCL-2-related Ovarian Death Gene) belongs to BCL-2 family of proteins containing BCL-2 homology domain3 (BH3). It is proapoptotic and exerts its effects by interacting with prosurvival members of the BCL-2 family like BCL-2, BCL-XL and BCL-W. It exhibits three splice variants; BIML, BIMS and BIMEL. They all share homology in their C-terminus BH3 domain and are ubiquitously expressed. BIMS is the strongest of them with respect to the proapoptotic capacity.
Product Description: B cell Oct binding protein 1 (BOB-1), is a transcription factor that is required for germinal center formation and immunoglobulin production. BOB-1 is expressed at high levels in spleen and peripheral blood leukocytes and represents an OCT co-factor capable of conferring cell specific activation of OCT-1 and OCT-2.
18
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Bone Morphogenetic Protein 4 (BMP-4) Rabbit Polyclonal
c-Abl Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Recombinant human BMP-4 protein.
E4000
0.1ml
Concentrate
Concentrate
Application: IHC-P
E4002
0.5ml
Concentrate
1.0ml
Concentrate
1.0ml
Concentrate
Ready-to-use
Species Reactivity: Human*
E4004
7.0ml
E4001
7.0ml
Ready-to-use
Catalog No.
Size
Format
E12510
0.1ml
E12510
0.5ml
E12514 E12511
Isotype: Rabbit IgG
Clone: N/A Immunogen: Synthetic peptide from the sequence adjacent to protein tyrosine kinase domain of human c-Abl. Application: IHC-P Species Reactivity: Human*
Control Tissue: Bone Marrow
Isotype: Rabbit IgG
Cellular Localization: Cytoplasm
Control Tissue: Placenta Cellular Localization: Cytoplasm
Human Bone Marrow stained with anti-Bone Morphogenetic Protein 4 (BMP-4) antibody E1251
Human Placenta stained with anti-c-Abl antibody E400
Product Description: Bone morphogenetic protein 4 (BMP4) is one of nine structurally related BMPs belonging to the transforming growth factor beta superfamily of secreted proteins. BMP4 has important roles as a signaling molecule in the developing central and peripheral nervous system, musculature and skeleton. BMP also plays an important role in early tooth morphogenesis.
Product Description: The c-Abl proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
C4d** Rabbit Monoclonal
Cadherin-E/E-Cadherin** Rabbit Monoclonal Clone: SP91
Catalog No.
Size
Format
M3640
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human C4d protein.
M3642
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 600-707 of human cadherin-E.
1.0ml
Concentrate
Application: IHC-P
M3644
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
M3641
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3910
0.1ml
Concentrate
M3912
0.5ml
M3914 M3911
Clone: SP64
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Breast Carcinoma, Colon
Cellular Localization: Secreted Protein
Cellular Localization: Membrane Control Lysate: MCF7 Molecular Weight: 135 kDa
Human Tonsil stained with anti-C4d antibody M391
Human Breast Carcinoma stained with anti-Cadherin-E/E-Cadherin antibody M364
Product Description: C4 plays a central role in the activation of the classical pathway of the complement system. Prior to secretion, the single-chain precursor is enzymatically cleaved to yield the non-identical chains (alpha, beta and gamma). During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.
Product Description: Cadherin-E/E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity.
C4d Rabbit Polyclonal
Cadherin-E/E-Cadherin Mouse Monoclonal Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Synthetic peptide of human C4d.
E8640
0.1ml
Concentrate
Concentrate
Application: IHC-P
E8642
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 600-707 of human cadherin-E.
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
Ready-to-use
Species Reactivity: Human*
E8644
7.0ml
E8641
7.0ml
Ready-to-use
Catalog No.
Size
Format
E17340
0.1ml
E17342
0.5ml
E17344 E17341
Isotype: Rabbit IgG
Clone: SPM471
Species Reactivity: Human* Isotype: Mouse IgG2b/k
Control Tissue: Kidney, Tonsil Cellular Localization: Secreted Protein
Control Tissue: Breast, Skin, Tonsil
Human Tonsil stained with anti-C4d antibody E1734
Human Breast stained with anti-Cadherin-E/E-Cadherin antibody E864
Product Description: C4 plays a central role in the activation of the classical pathway of the complement system. Prior to secretion, the single-chain precursor is enzymatically cleaved to yield the non-identical chains (alpha, beta and gamma). During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.
Cellular Localization: Membrane
Product Description: E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
19
Cadherin-E/E-Cadherin Rabbit Polyclonal
Cadherin-pan Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2360
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 600-707 of human cadherin-E.
E2362
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of chicken cadherin-N protein.
1.0ml
Concentrate
Application: IHC-P
E2364
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E2361
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3460
0.1ml
Concentrate
E3462
0.5ml
E3464 E3461
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast, Skin, Tonsil
Control Tissue: Skin, Tonsil
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Skin stained with anti-Cadherin-E/E-Cadherin antibody E346
Human Skin stained with anti-Cadherin-pan antibody E236
Product Description: E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity.
Product Description: Cadherins are calcium dependent cell adhesion molecules, which play important roles in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. In adhesion junctions, cadherins are bound to β and γ catenins, which in turn bind to α catenin, an actin-binding protein. Cadherins play important roles in tumor invasion and metastasis.
Cadherin-N/N-Cadherin Rabbit Monoclonal
Calbindin D28 Rabbit Polyclonal
Clone: SP90
Catalog No.
Size
Format
E10340
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human cadherin-N protein.
E10342
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human calbindin D28K protein.
1.0ml
Concentrate
Application: IHC-P
E10344
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
E10341
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3900
0.1ml
Concentrate
M3902
0.5ml
M3904 M3901
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Mesothelioma
Control Tissue: Cerebellum, Kidney
Cellular Localization: Membrane
Cellular Localization: Cytoplasm Control Lysate: Human Kidney Molecular Weight: 28 kDa
Human Mesothelioma stained with anti-Cadherin-N/N-Cadherin antibody M390
Human Cerebellum stained with anti-Calbindin D28 antibody E1034
Product Description: Cadherin-N/N-cadherin is a 140kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion. The function of N-cadherin is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminus region of N-cadherin and the cytoplasmic catenin proteins.
Product Description: Calbindin-D-28K is a highly conserved calcium binding protein. It belongs to a family of low molecular weight calcium-binding proteins (CaBPs). Calbindin-D-28K is found predominantly in subpopulations of central and peripheral nervous system neurons, and in certain epithelial nervous system neurons, and in certain epithelial cells involved in Ca2+ transport such as distal tubular cells and cortical collecting tubules of the kidney, and in enteric neuroendocrine cells.
Cadherin-N/N-Cadherin Rabbit Polyclonal
Calcitonin Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3170
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human cadherin-N protein.
M3172
0.5ml
Concentrate
Immunogen: Synthetic human calcitonin 1-32 amino acid peptide.
1.0ml
Concentrate
Application: IHC-P
M3174
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M3171
7.0ml
Ready-to-use
Catalog No.
Size
Format
E18260
0.1ml
Concentrate
E18262
0.5ml
E18264 E18261
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Adrenal Gland, Liver, Pancreas
Control Tissue: Thyroid, Thyroid Medullary Carcinoma
Cellular Localization: Membrane
Cellular Localization: Cytoplasm
Human Liver stained with anti-Cadherin-N/N-Cadherin antibody E1826
Human Thyroid Medullary Carcinoma stained with anti-Calcitonin antibody M317
Product Description: Cadherin-N/N-cadherin is a 140kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion. The function of N-cadherin is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminus region of N-cadherin and the cytoplasmic catenin proteins.
20
Clone: SP17
Product Description: Calcitonin is a 32 amino acid peptide which can be demonstrated in C cells of the normal and hyperplastic thyroid. Calcitonin is expressed in a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Calcitonin Rabbit Polyclonal
Calpain Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18780
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic human calcitonin 1-32 amino acid peptide.
E18782
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human calpain protein.
1.0ml
Concentrate
Application: IHC-P, WB
E18784
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E18781
7.0ml
Ready-to-use
Catalog No.
Size
Format
E1150
0.1ml
Concentrate
E1152
0.5ml
E1154 E1151
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Thyroid, Thyroid Medullary Carcinoma
Control Tissue: Breast Carcinoma Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm Control Lysate: Human Thyroid Molecular Weight: 14 kDa
Human Breast Carcinoma stained with anti-Calpain antibody E1878
Human Thyroid stained with anti-Calcitonin antibody E115
Product Description: Calcitonin is a 32 amino acid peptide which can be demonstrated in C cells of the normal and hyperplastic thyroid. Calcitonin is expressed in a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.
Product Description: Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes due to calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. Calpain S1 is a small subunit common to both Calpain I and II and is associated with myotonic dystrophy.
Calcium Sensing Receptor (CaSR) Rabbit Polyclonal
Calpastatin Rabbit Monoclonal Clone: SP82
Clone: N/A
Catalog No.
Size
Format
M3820
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from N-terminus of rat calcium sensing receptor.
M3822
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from near C-terminus of human calpastatin protein.
1.0ml
Concentrate
Application: IHC-P
M3824
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
M3821
7.0ml
Ready-to-use
Catalog No.
Size
Format
E10620
0.1ml
Concentrate
E10622
0.5ml
E10624 E10621
Species Reactivity: Human*
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Placenta Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Placenta stained with anti-Calcium Sensing Receptor (CaSR) antibody E1062
Human Breast Carcinoma stained with anti-Calpastatin antibody M382
Product Description: The calcium sensing receptor (CaSR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo).
Product Description: Calpastatin is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. Calpastatin, a specific endogenous inhibitor of calpain, functions by binding to calpain. It contains mutliple inhibitory fragments for calpain activity.
Calpain Rabbit Monoclonal
Calpastatin Rabbit Polyclonal Clone: N/A
Clone: SP81
Catalog No.
Size
Format
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human calpain protein.
E18790 E18792
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from near C-terminus of human calpastatin protein.
1.0ml
Concentrate
Application: IHC-P, WB
E18794
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
E18791
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3810
0.1ml
Concentrate
M3812
0.5ml
M3814 M3811
Species Reactivity: Human*, Mouse*
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm Control Lysate: 293T Molecular Weight: 28 kDa
Human Breast Carcinoma stained with anti-Calpastatin antibody E1879
Human Breast Carcinoma stained with anti-Calpain antibody M381
Product Description: Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes due to calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. Calpain S1 is a small subunit common to both Calpain I and II and is associated with myotonic dystrophy.
Product Description: Calpastatin is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. Calpastatin, a specific endogenous inhibitor of calpain, functions by binding to calpain. It contains mutliple inhibitory fragments for calpain activity.
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International Orders Email: intlorders@springbio.com
21
Calretinin Rabbit Monoclonal
CaM Kinase Kinase alpha Rabbit Polyclonal Clone: SP13
Catalog No.
Size
Format
E13850
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant full length mouse calretinin protein.
E13852
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human CaM kinase kinase alpha.
1.0ml
Concentrate
Application: IHC-P
E13854
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E13851
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3130
0.1ml
Concentrate
M3132
0.5ml
M3134 M3131
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Mesothelioma
Control Tissue: Brain
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Nucleus
Human Mesothelioma stained with anti-Calretinin antibody M313
Human Brain stained with anti-CaM Kinase Kinase alpha antibody E1385
Product Description: Calretinin is an intracellular calcium-binding protein belonging to the troponin C superfamily. The immunohistochemical detection of calretinin in developing cerebellum is restricted to the later stages indicated by weak staining from week 21 of gestation in Purkinje and basket cells and in neurons of the dentate nucleus. In tumors, calretinin has been detected in mesotheliomas and some pulmonary adenocarcinomas.
Product Description: Ca2+/Calmodulin dependent protein kinases (CaM Kinase I, II and IV) are considered to play a central role in many cellular functions in response to Ca2+ signaling, including synthesis and secretion of neurotransmitters, axonal transport, long term potentiation (LTP), receptor function, modification of the cytoskeleton and regulation of gene expression.
Calretinin Rabbit Polyclonal
Carbonic Anhydrase 9 (CA-9) Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M4060
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant full length mouse calretinin protein.
M4062
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from human CA-9.
1.0ml
Concentrate
Application: IHC-P, WB
M4064
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M4061
7.0ml
Ready-to-use
Catalog No.
Size
Format
E1170
0.1ml
Concentrate
E1172
0.5ml
E1174 E1171
Clone: SP106
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Mesothelioma
Control Tissue: Stomach
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Membrane, Nucleus
Control Lysate: Human Brain Molecular Weight: 29 kDa Human Mesothelioma stained with anti-Calretinin antibody E117
Human Stomach stained with anti-Carbonic Anhydrase 9 (CA-9) antibody M406
Product Description: Calretinin is an intracellular calcium-binding protein belonging to the troponin C superfamily. The immunohistochemical detection of calretinin in developing cerebellum is restricted to the later stages indicated by weak staining from week 21 of gestation in Purkinje and basket cells and in neurons of the dentate nucleus. In tumors, calretinin has been detected in mesotheliomas and some pulmonary adenocarcinomas.
Product Description: Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. CA-9 is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. CA-9 is a reliable histochemical marker of hypoxia.
CaM Kinase IV Rabbit Polyclonal
Carbonic Anhydrase 9 (CA-9) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18420
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of rat CaM kinase IV.
E18422
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from human CA-9.
1.0ml
Concentrate
Application: IHC-P
E18424
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
E18421
7.0ml
Ready-to-use
Catalog No.
Size
Format
E10600
0.1ml
Concentrate
E10602
0.5ml
E10604 E10601
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain
Control Tissue: Stomach
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Membrane, Nucleus Control Lysate: Ramos Molecular Weight: 50 kDa
Human Brain stained with anti-CaM Kinase IV antibody E1060
Product Description: Calmodulin dependent protein kinases (CaM kinases) consist of a family of Ser/Thr protein kinases including CaMKI, CaMKII and CaMKIV. CaMKs play a central role in many cellular functions in response to Ca2+ signaling, including synthesis and secretion of neurotransmitters, axonal transport, long term potentiation etc. CaM kinase IV is abundantly expressed in the brain and in the thymus and is localized to the cytoplasm and nucleus.
22
Human Stomach stained with anti-Carbonic Anhydrase 9 (CA-9) antibody E1842
Product Description: Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux and it can be used as a histochemical marker of hypoxia.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies CAS Rabbit Polyclonal
Caspase-10 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E10850
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from N-terminus of human CAS.
E10852
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human caspase-10.
1.0ml
Concentrate
Application: IHC-P
E10854
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E10851
7.0ml
Ready-to-use
Catalog No.
Size
Format
E10810
0.1ml
Concentrate
E10812
0.5ml
E10814 E10811
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Liver Carcinoma
Control Tissue: Liver Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Liver Carcinoma stained with anti-CAS antibody E1081
Human Liver Carcinoma stained with anti-Caspase-10 antibody E1085
Product Description: CAS (Cellular Apoptosis Susceptibility) contains 971 amino acids with 59% overall sequence homology as compared to yeast chromosome segregation homolog, CSE1. CAS is highly expressed in testis and fetal liver. CAS expression in human fibroblasts increases as cells are induced to proliferate and decreases in growth arrested cells.
Product Description: Caspase-10 is a member of the Ced-3 cystein protease family and it has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli. Caspase-1 to-10 function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity.
Caspase-1 Rabbit Polyclonal
Catenin-beta Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2260
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human caspase-1 protein.
E2262
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of the catenin-beta protein.
1.0ml
Concentrate
Application: IHC-P
E2264
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
E2261
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3910
0.1ml
Concentrate
E3912
0.5ml
E3914 E3911
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane Control Lysate: A431 Molecular Weight: 92 kDa
Human Placenta stained with anti-Caspase-1 antibody E391
Human Breast Carcinoma stained with anti-Catenin-beta antibody E226
Product Description: Caspase-1/ICE (Interleukin-1 Beta Converting Enzyme) is expressed as a proenzyme of 45kDa in many tissues and is activated by proteolytic cleavage. Active caspase-1 is a tetramer of two subunits p10 and p20. Caspase-1 (cystein aspartic-specific protease 1) cleaves interleukin beta into its active form which further exerts its proinflammatory effects. Overexpression of caspase-1 can induce apoptosis in fibroblasts.
Product Description: The catenins (α, β and γ) are ubiquitously expressed, cytoplasmic proteins associated with E-cadherin at cellular junctions. β-catenin also binds to N-cadherin and co-immunoprecipitates with APC. Cadherin/catenin complexes are linked to the cytoskeleton via a direct association between α-actin and α-catenin. Increased tyrosine phosphorylation can disrupt catenin-cadherin complexes, influencing cellular adhesion.
Caspase-8 Rabbit Polyclonal
Catenin-gamma Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E3680
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human caspase-8 protein.
E3682
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human catenin-gamma protein.
1.0ml
Concentrate
Application: IHC-P
E3684
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E3681
7.0ml
Ready-to-use
Catalog No.
Size
Format
E2280
0.1ml
Concentrate
E2282
0.5ml
E2284 E2281
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Stomach
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Human Stomach stained with anti-Caspase-8 antibody E228
Human Breast Carcinoma stained with anti-Catenin-gamma antibody E368
Product Description: Caspase-8 binds to the death effector domain (DED) through an analogous DED domain. Recruitment of caspase-8 to the Fas receptor results in oligomerization of the caspase-8 protein, which in turn drives its autoactivation through “self-cleavage.” Activated caspase-8 then activates other downstream caspases including caspase-9, thereby commiting the cell to undergo apoptosis. This antibody also detects the processed forms (42/44kDa, 25kDA, and 14kDa) of caspase-8.
Product Description: The catenins (α, β and γ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin. α-catenin can also bind P-cadherin and N-cadherin. γ-catenin, also known as plakoglobin, is an 82kDa protein that binds with α-catenin and N-cadherin.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
23
Cathepsin D Rabbit Polyclonal
Caveolin-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Recombinant human cathepsin D protein.
E10780
0.1ml
Concentrate
Concentrate
Application: IHC-P
E10782
0.5ml
Concentrate
Immunogen: Synthetic peptide from N-terminus of human caveolin-1.
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
Ready-to-use
Species Reactivity: Human*
E10784
7.0ml
E10781
7.0ml
Ready-to-use
Catalog No.
Size
Format
E2820
0.1ml
E2822
0.5ml
E2824 E2821
Isotype: Rabbit IgG
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma Cellular Localization: Cytoplasm
Control Tissue: Lung Carcinoma
Human Breast Carcinoma stained with anti-Cathepsin D antibody E282
Human Lung Carcinoma stained with anti-Caveolin-1 antibody E1078
Cellular Localization: Cytoplasm, Membrane
Product Description: Cathepsin D is synthesized as a 54kDa precursor and is proteolytically processed to an intermediate 48kDa single chain. The 48KDa form is further processed into the more stable 34kDa and 14kDa mature forms. Cathepsin D is an estrogen-regulated lysosomal protease that facilitates cancer cell migration and invasion by digesting the basement membrane, extracellular matrix, and connective tissue. Cathepsin D is expressed in epithelial cells as well as in macrophages.
Product Description: Caveolae are 50-100 nm flask-shaped subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules across capillary endothelial cells, uptake of small molecules via potocytosis and the compartmentalization of certain signaling molecules or receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3 have been identified as principle components of caveolae.
Caveolin-1 Rabbit Monoclonal
CBP/p300-Interacting Transactivator 1 (CITED-1) Rabbit Polyclonal
Clone: SP43
Catalog No.
Size
Format
E3510
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human caveolin-1 protein.
E3512
0.5ml
Concentrate
Immunogen: Recombinant full-length human CITED-1 protein.
1.0ml
Concentrate
Application: IHC-P
E3514
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*, Mouse*
E3511
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3430
0.1ml
Concentrate
M3432
0.5ml
M3434 M3431
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung, Lung Carcinoma Cellular Localization: Cytoplasm, Membrane
Control Tissue: Breast Carcinoma, Papillary Thyroid Carcinoma
Human Lung Carcinoma stained with anti-Caveolin-1 antibody M343
Human Breast Carcinoma stained with anti-CBP/p300-Interacting Transactivator 1 (CITED-1) antibody E351
Cellular Localization: Cytoplasm, Nucleus
Product Description: Caveolae are 50-100 nm flask-shaped subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules across capillary endothelial cells, uptake of small molecules via potocytosis and the compartmentalization of certain signaling molecules or receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3 have been identified as principle components of caveolae.
Product Description: CITED1 (CBP/p300-Interacting Transactivator 1)/Melanocytespecific protein 1 is highly expressed in most of the papillary thyroid carcinoma. It is not expressed in normal tissues except normal breast epithelium. Studies show that this protein functions as a selective coactivator for estrogen-dependent transcription.
Caveolin-1 Rabbit Polyclonal
CCR7 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18460
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human caveolin-1.
E18462
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from human CCR7.
1.0ml
Concentrate
Application: IHC-P
E18464
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E18461
7.0ml
Ready-to-use
Catalog No.
Size
Format
E17640
0.1ml
Concentrate
E17642
0.5ml
E17644 E17641
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung, Lung Carcinoma
Control Tissue: Small Intestine
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Membrane
Human Lung stained with anti-Caveolin-1 antibody E1764
Human Small Intestine stained with anti-CCR7 antibody E1846
Product Description: Caveolae are 50-100 nm flask-shaped subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules across capillary endothelial cells, uptake of small molecules via potocytosis and the compartmentalization of certain signaling molecules or receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3 have been identified as principle components of caveolae.
24
Clone: N/A
Product Description: C-C chemokine receptor type 7 (CCR7) is a member of the G protein coupled receptor family (subfamily: chemokine). This receptor was identified as a gene induced by the Epstein Barr virus (EBV). It is expressed particularly in lymphoid tissues and in activated B and T lymphocytes and has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies CCR8 Rabbit Polyclonal
CD3 Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3070
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from aa 183-193 of human CCR8.
M3072
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
M3074
1.0ml
Concentrate
7.0ml
Ready-to-use
Species Reactivity: Human*
M3071
7.0ml
Ready-to-use
Catalog No.
Size
Format
E10790
0.1ml
Concentrate
E10792
0.5ml
E10794 E10791
Clone: SP7 Immunogen: Synthetic peptide corresponding to internal region of the epsilon chain of human CD3 protein. Application: IHC-P, WB Species Reactivity: Human*, Mouse*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Thymus
Control Tissue: Tonsil
Cellular Localization: Membrane
Cellular Localization: Membrane Control Lysate: Jurkat Molecular Weight: 20 kDa
Human Thymus stained with anti-CCR8 antibody E1079
Human Tonsil stained with anti-CD3 antibody M307
Product Description: C-C chemokine receptor type 8 (CCR8) encodes a member of the beta chemokine receptor family. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP1 beta) have been identified as ligands of this receptor. CCR8 expression has been reported in spleen and thymus, natural-killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes.
Product Description: This antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by T cells. It stains human T cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues. This antibody is suitable for staining normal and neoplastic T cells in formalin-fixed, paraffin-embedded tissues.
CD1 alpha Rabbit Polyclonal
CD3 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E1250
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 19-327 of human CD1 alpha.
E1252
0.5ml
Concentrate
1.0ml
Concentrate
Application: WB
E1254
1.0ml
Concentrate
N/A
N/A
Species Reactivity: Human*
E1251
7.0ml
Ready-to-use
Catalog No.
Size
Format
E4710
0.1ml
Concentrate
E4712
0.5ml
E4714 N/A
Clone: N/A Immunogen: Synthetic 13-mer peptide corresponding to internal region of the epsilon chain of human CD3 protein. Application: IHC-P, WB Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: N/A
Control Tissue: Tonsil
Cellular Localization: N/A
Cellular Localization: Membrane
Control Lysate: K562 Molecular Weight: 49 kDa
Control Lysate: Jurkat
N/A E471
Human Tonsil stained with anti-CD3 antibody E125
Molecular Weight: 19 kDa
Product Description: At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 is expressed on cortical thymocytes, Langerhans cells, and dendritic cells. It is absent on mature peripheral blood T cells but intracytoplasmic expression is detected on activated T lymphocytes. CD1 proteins have been demonstrated to restrict T-cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation.
Product Description: This antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by T cells. It stains human T cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues. This antibody is suitable for staining normal and neoplastic T cells in formalin-fixed, paraffin-embedded tissues.
CD2 Rabbit Polyclonal
CD3 zeta Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E3050
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 25-209 of human CD2 .
E3052
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from near N-terminus of the zeta chain of human CD3 protein.
1.0ml
Concentrate
Application: IHC-P, WB
E3054
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E3051
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3040
0.1ml
Concentrate
E3042
0.5ml
E3044 E3041
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Membrane
Cellular Localization: Membrane
Control Lysate: Jurkat Molecular Weight: 45-58 kDa Human Tonsil stained with anti-CD2 antibody E304
Product Description: The CD2 antigen (LFA-2) is a monomeric 45 to 58kDa glycoprotein. It is an accessory molecule important in mediating the adhesion of activated T cells and thymocytes with antigen-presenting cells and target cells. This antibody reacts with the majority of T cells in peripheral lymphoid tissue, NK cells, cortical thymocytes and most malignant cells of T cell origin.
Human Tonsil stained with anti-CD3 zeta antibody E305
Product Description: CD3 consists of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains, a heterodimer of delta and epsilon chains and a homodimer of two zeta chains or a heterodimer of zeta and eta chains. The zeta chain contains three consecutive copies of the same motif.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
25
CD4 Rabbit Monoclonal
CD5 Rabbit Polyclonal Clone: SP35
Catalog No.
Size
Format
E2470
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human CD4.
E2472
0.5ml
Concentrate
Immunogen: Synthetic peptide from the intracellular region of CD5.
1.0ml
Concentrate
Application: IHC-P
E2474
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E2471
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3350
0.1ml
Concentrate
M3352
0.5ml
M3354 M3351
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: T Cell Lymphoma, Tonsil
Control Tissue: Tonsil
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Tonsil stained with anti-CD4 antibody M335
Human Tonsil stained with anti-CD5 antibody E247
Product Description: CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV and is expressed in T-cell lymphomas.
Product Description: CD5, a transmembrane protein, is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Occasionally, CD5 antigen is also expressed on a subset of B cells. Mantle cell lymphomas (same as diffuse centrocytic lymphomas) are CD5+ while the follicle center cell lymphoma are CD5-.
CD4 Rabbit Polyclonal
CD7** Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3940
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human CD4.
M3942
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human CD7 protein.
1.0ml
Concentrate
Application: IHC-P
M3944
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M3941
7.0ml
Ready-to-use
Catalog No.
Size
Format
E17680
0.1ml
Concentrate
E17682
0.5ml
E17684 E17681
Clone: SP94
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Tonsil stained with anti-CD4 antibody E1768
Human Tonsil stained with anti-CD7 antibody M394
Product Description: CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV and is expressed in T-cell lymphomas.
Product Description: CD7 (gp40, Leu9) is a member of the immunoglobulin gene superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T cell interactions and also in T cell/B cell interactions during early lymphoid development. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on maligant B cells.
CD5 Rabbit Monoclonal
CD7 Rabbit Polyclonal Clone: SP19
Catalog No.
Size
Format
E18930
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from the intracellular region of human CD5.
E18932
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human CD7 protein.
1.0ml
Concentrate
Application: IHC-P
E18934
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E18931
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3190
0.1ml
Concentrate
M3192
0.5ml
M3194 M3191
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Tonsil stained with anti-CD5 antibody M319
Human Tonsil stained with anti-CD7 antibody E1893
Product Description: CD5, a transmembrane protein, is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Occasionally, CD5 antigen is also expressed on a subset of B cells. Mantle cell lymphomas (same as diffuse centrocytic lymphomas) are CD5+ while the follicle center cell lymphoma are CD5-.
26
Clone: N/A
Product Description: CD7 (gp40, Leu9) is a member of the immunoglobulin gene superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T cell interactions and also in T cell/B cell interactions during early lymphoid development. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on maligant B cells.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies CD8 Rabbit Monoclonal
CD10** Rabbit Monoclonal Clone: SP16
Catalog No.
Size
Format
M3670
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of alpha chain of the human CD8 molecule.
M3672
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to human CD10.
1.0ml
Concentrate
Application: IHC-P
M3674
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
M3671
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3160
0.1ml
Concentrate
M3162
0.5ml
M3164 M3161
Clone: SP67
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Renal Cell Carcinoma, Tonsil
Cellular Localization: Membrane
Cellular Localization: Cytoplasm, Membrane Control Lysate: Ramos Molecular Weight: 100 kDa
Human Tonsil stained with anti-CD8 antibody M316
Human Renal Cell Carcinoma stained with anti-CD10 antibody M367
Product Description: The CD8 molecule consists of two chains, termed α and β chain, which are expressed as a disulfide-linked α/β heterdimer or as an α/α homodimer on T cell subset, thymocytes and NK cells. The majority of CD8+ T cells express CD8 as α/β heterdimer. CD8 functions as a coreceptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 α chain (but not β chain).
Product Description: CD10, also known as the Common Acute Lymphocytic Leukemia Antigen (CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity. CD10 is expressed on the cells of lymphoblastic, Burkitt’s, and follicular lymphomas, immature B cells, chronic myelocytic leukemia, and renal clear cell carcinoma. It is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border kidney, and gut epithelial cells.
CD8 Rabbit Polyclonal
CD10 Rabbit Polyclonal
Catalog No.
Size
Format
E2480
0.1ml
Concentrate
E2482
0.5ml
Concentrate
E2484
1.0ml
Concentrate
E2481
7.0ml
Ready-to-use
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to C-terminus of the cytoplasmic domain of alpha chain of the CD8 molecule.
E18270
0.1ml
Concentrate
E18272
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human CD10.
E18274
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
E18271
7.0ml
Ready-to-use
Species Reactivity: Human*
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Kidney, Tonsil
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Membrane
Human Tonsil stained with anti-CD8 antibody E248
Human Kidney stained with anti-CD10 antibody E1827
Product Description: The CD8 molecule consists of two chains, termed α and β chain, which are expressed as a disulfide-linked α/β heterdimer or as an α/α homodimer on T cell subset, thymocytes and NK cells. The majority of CD8+ T cells express CD8 as α/β heterdimer. CD8 functions as a coreceptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 α chain (but not β chain).
Product Description: CD10, also known as the Common Acute Lymphocytic Leukemia Antigen (CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity. CD10 is expressed on the cells of lymphoblastic, Burkitt’s, and follicular lymphomas, immature B cells, chronic myelocytic leukemia, and renal clear cell carcinoma. It is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border kidney, and gut epithelial cells.
CD9 Rabbit Polyclonal
CD19 Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M4100
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant human full-length CD9 protein.
M4102
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human CD19.
1.0ml
Concentrate
Application: IHC-P
M4104
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M4101
7.0ml
Ready-to-use
Catalog No.
Size
Format
E11010
0.1ml
Concentrate
E11012
0.5ml
E11014 E11011
Clone: SP110
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Tonsil stained with anti-CD9 antibody E1101
Human Tonsil stained with anti-CD19 antibody M410
Product Description: The CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophils, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. In pre-B cells and platelets, CD9 antigen regulates cell activation aggregation possibly through an association with the integrin CD41/CD61. It also regulates cell motility in a variety of cell lines.
Product Description: CD19 is expressed in B lymphocytes and B cell lymphoma. It may also be present on some early myeloid progenitors, particularly those of the monoblastic type. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. CD19 is negative in T lymphocytes, plasma cells, and their tumors.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
27
CD19 Rabbit Polyclonal
CD22** Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M4040
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human CD19 protein.
M4042
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human CD22.
1.0ml
Concentrate
Application: IHC-P
M4044
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M4041
7.0ml
Ready-to-use
Catalog No.
Size
Format
E18960
0.1ml
Concentrate
E18962
0.5ml
E18964 E18961
Clone: SP104
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Membrane
Cellular Localization: Cytoplasm, Membrane
Human Tonsil stained with anti-CD19 antibody E1896
Human Tonsil stained with anti-CD22 antibody M404
Product Description: CD19 is expressed in B lymphocytes and B-cell lymphoma. It may also be present on some early myeloid progenitors, particularly those of the monoblastic type. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. CD19 is negative in T lymphocytes, plasma cells, and their tumors.
Product Description: CD22 is a type 1 integral membrane glycoprotein expressed in both the cytoplasm and cell membrane of B lymphocytes. CD22 antigen appears early in B cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. CD22 membrane expression is limited to the late differentiation stages. There are two different isoforms of CD22. It exists as a monomer and heterodimer. CD22 is strongly expressed in hairy cell leukemia.
CD20 Rabbit Monoclonal
CD22 Rabbit Polyclonal Clone: SP32
Catalog No.
Size
Format
E19020
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human CD20 protein.
E19022
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human CD22.
1.0ml
Concentrate
Application: IHC-P, WB
E19024
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E19021
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3320
0.1ml
Concentrate
M3322
0.5ml
M3324 M3321
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: B Cell Lymphoma, Tonsil
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm, Membrane
Control Lysate: Ramos Molecular Weight: 35 kDa Human B Cell Lymphoma stained with anti-CD20 antibody M332
Human Tonsil stained with anti-CD22 antibody E1902
Product Description: CD20 is a leukocyte surface antigen consisting of four transmembrane regions and cytoplasmic N- and C-termini. CD20 is expressed primarily on B cells but has also been detected on both normal and neoplastic T cells. Activation of CD20 significantly increases DNA synthesis and is thought to involve basic helix-loop-helix leucine zipper transcription factors.
Product Description: CD22 is a type 1 integral membrane glycoprotein expressed in both the cytoplasm and cell membrane of B lymphocytes. CD22 antigen appears early in B cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. CD22 membrane expression is limited to the late differentiation stages. There are two different isoforms of CD22. It exists as a monomer and heterodimer. CD22 is strongly expressed in hairy cell leukemia.
CD20 Rabbit Polyclonal
CD23 Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3230
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human CD20 protein.
M3232
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 48-248 of human CD23.
1.0ml
Concentrate
Application: IHC-P, WB
M3234
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
M3231
7.0ml
Ready-to-use
Catalog No.
Size
Format
E2560
0.1ml
Concentrate
E2562
0.5ml
E2564 E2561
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: B Cell Lymphoma, Tonsil
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Membrane
Control Lysate: Raji
Molecular Weight: 45 kDa
Molecular Weight: 35 kDa Human Tonsil stained with anti-CD20 antibody E256
Product Description: CD20 is a leukocyte surface antigen consisting of four transmembrane regions and cytoplasmic N- and C-termini. CD20 is expressed primarily on B cells but has also been detected on both normal and neoplastic T cells. Activation of CD20 significantly increases DNA synthesis and is thought to involve basic helix-loophelix leucine zipper transcription factors.
28
Clone: SP23
Control Lysate: Raji
Human Tonsil stained with anti-CD23 antibody M323
Product Description: CD23 is a 45kDa glycoprotein, which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukemia and some cases of centroblastic/ centrocytic lymphoma.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies CD23 Rabbit Polyclonal
CD31 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E11110
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 48-248 of human CD23.
E11112
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of mouse CD31 protein.
1.0ml
Concentrate
Application: IHC-P
E11114
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E11111
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3020
0.1ml
Concentrate
E3022
0.5ml
E3024 E3021
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Tonsil stained with anti-CD23 antibody E302
Human Tonsil stained with anti-CD31 antibody E1111
Product Description: CD23 is a 45kDa glycoprotein, which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukemia and some cases of centroblastic/ centrocytic lymphoma.
Product Description: CD31 is a glycoprotein expressed on endothelial cells and in platelets. It is known to be involved in cell signaling and cell adhesion.
CD30 Rabbit Polyclonal
CD34 (Endothelial Cell Marker) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E17540
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human CD30.
E17542
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to human CD34 protein.
1.0ml
Concentrate
Application: IHC-P
E17544
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E17541
7.0ml
Ready-to-use
Catalog No.
Size
Format
E17410
0.1ml
Concentrate
E17412
0.5ml
E17414 E17411
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Hodgkin’s Lymphoma, Tonsil
Control Tissue: Angiosarcoma, Lung, Tonsil
Cellular Localization: Membrane
Cellular Localization: Cytoplasm, Membrane
Human Hodgkin’s Lymphoma stained with anti-CD30 antibody E1741
Human Angiosarcoma stained with anti-CD34 (Endothelial Cell Marker) antibody E1754
Product Description: CD30, a single chain glycoprotein, is synthesized as a 90kDa precursor which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. The CD30/Ki-1 antigen is expressed by mononuclear Hodgkin and multinucleated Reed-Sternberg cells in Hodgkin’s disease, by the tumor cells of a majority of anaplastic large cell lymphomas, and by a varying proportion of activated T and B cells.
Product Description: CD34, a single chain transmembrane glycoprotein, is selectively expressed on human lymphoid and myeloid hematopoietic progenitor cells.
CD31 Rabbit Monoclonal
CD34 (Endothelial Cell Marker) Mouse Monoclonal Clone: SP38
Catalog No.
Size
Format
E1280
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of mouse CD31 protein.
E1282
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E1284
1.0ml
Concentrate
7.0ml
Ready-to-use
Species Reactivity: Human*, Mouse*
E1281
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3380
0.1ml
Concentrate
M3382
0.5ml
M3384 M3381
Clone: QBEnd/10 Immunogen: Detergent solubilized vesicular suspension prepared from a perfusate of human term placenta. Application: IHC-P Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Mouse IgG1/k
Control Tissue: Tonsil Cellular Localization: Membrane
Control Tissue: Lung, Tonsil
Human Tonsil stained with anti-CD31 antibody M338
Human Tonsil stained with anti-CD34 (Endothelial Cell Marker) antibody E128
Product Description: CD31 is a glycoprotein expressed on endothelial cells and in platelets. It is known to be involved in cell signaling and cell adhesion.
Cellular Localization: Cytoplasm, Membrane
Product Description: CD34, a single chain transmembrane glycoprotein, is selectively expressed on human lymphoid and myeloid hematopoietic progenitor cells.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
29
CD38 Rabbit Polyclonal
CD43 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E17950
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide near the C-terminus of human CD38.
E17952
0.5ml
Concentrate
Immunogen: Synthetic peptide from internal region of human CD43 protein.
1.0ml
Concentrate
Application: IHC-P, WB
E17954
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E17951
7.0ml
Ready-to-use
Catalog No.
Size
Format
E19170
0.1ml
Concentrate
E19172
0.5ml
E19174 E19171
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Membrane
Control Lysate: HeLa Molecular Weight: 46 kDa (predicted) Human Tonsil stained with anti-CD38 antibody E1917
Human Tonsil stained with anti-CD43 antibody E1795
Product Description: CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a transmembrane glycoprotein found on the surface of many immune cells including plasma cells, activated or immature T and B cells, monocytes, and natural killer cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. CD38 is used as one of the plasma cell markers and its ligand is CD31 molecules.
Product Description: CD43 is one of the major glycoproteins of thymocytes and T lymphocytes. It plays a role in the physiochemical properties of the T cell surface and in lectin binding. CD43 presents carbohydrate ligands to selectins. It has an extended rod-like structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. During T cell activation CD43 is actively removed from the T cell antigen presenting cell contact site.
CD40 Rabbit Polyclonal
CD44 Std** Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3370
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human CD40.
M3372
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to human CD44.
1.0ml
Concentrate
Application: IHC-P
M3374
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
M3371
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3700
0.1ml
Concentrate
E3702
0.5ml
E3704 E3701
Clone: SP37
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Hodgkin’s Lymphoma, Tonsil
Control Tissue: Esophageal Carcinoma
Cellular Localization: Membrane
Cellular Localization: Membrane Control Lysate: HeLa Molecular Weight: 80 kDa
Human Hodgkin’s Lymphoma stained with anti-CD40 antibody E370
Human Esophageal Carcinoma stained with anti-CD44 Std antibody M337
Product Description: The CD40 antigen is a single chain glycoprotein. It is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin’s disease associated antigen, CD30. CD40 is present on all B cells except plasma cells. It is also found on some epithelial cells, carcinomas and lymphoid dentritic cells.
Product Description: CD44 is a cell surface glycoprotein expressed on lymphocytes, monocytes, and granulocytes. CD44 is also known as homing cell adhesion molecule (H-CAM), phagocytic glycoprotein-1 (PgP-1), ECM-III, HUTCH-1, or Hermes-1. CD44 has been implicated in cell migration, in lymphocyte homing, and in tumor metastasis.
CD43 Rabbit Monoclonal
CD44 Std Rabbit Polyclonal Clone: SP55
Catalog No.
Size
Format
E17370
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from the human CD43.
E17372
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human CD44.
1.0ml
Concentrate
Application: IHC-P, WB
E17374
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E17371
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3550
0.1ml
Concentrate
M3552
0.5ml
M3554 M3551
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Esophageal Carcinoma
Cellular Localization: Membrane
Cellular Localization: Membrane
Control Lysate: Jurkat Molecular Weight: 95/115/135 kDa Human Tonsil stained with anti-CD43 antibody M355
Product Description: CD43 is one of the major glycoproteins of thymocytes and T lymphocytes. It plays a role in the physiochemical properties of the T cell surface and in lectin binding. CD43 presents carbohydrate ligands to selectins. It has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. During T cell activation CD43 is actively removed from the T cell antigen presenting cell contact site.
30
Human Esophageal Carcinoma stained with anti-CD44 Std antibody E1737
Product Description: CD44 is a cell surface glycoprotein expressed on lymphocytes, monocytes, and granulocytes. CD44 is also known as homing cell adhesion molecule (H-CAM), phagocytic glycoprotein-1 (PgP-1), ECM-III, HUTCH-1, or Hermes-1. CD44 has been implicated in cell migration, in lymphocyte homing, and in tumor metastasis.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies CD44 Std Mouse Monoclonal
CD56 Mouse Monoclonal Clone: SPM521
Catalog No.
Size
Format
E1370
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to human CD44.
E1372
0.5ml
Concentrate
Immunogen: Membrane preparation of a small cell lung carcinoma.
1.0ml
Concentrate
Application: IHC-P, WB
E1374
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E1371
7.0ml
Ready-to-use
Catalog No.
Size
Format
E17360
0.1ml
Concentrate
E17362
0.5ml
E17364 E17361
Clone: SPM128
Species Reactivity: Human*
Isotype: Mouse IgG2a
Isotype: Mouse IgG1/k
Control Tissue: Esophageal Carcinoma
Control Tissue: Brain, Neuroblastoma
Cellular Localization: Membrane
Cellular Localization: Membrane
Control Lysate: HeLa Molecular Weight: 80 kDa Human Esophageal Carcinoma stained with anti-CD44 Std antibody E1736
Human Neuroblastoma stained with anti-CD56 antibody E137
Product Description: CD44 is a cell surface glycoprotein expressed on lymphocytes, monocytes, and granulocytes. CD44 is also known as homing cell adhesion molecule (H-CAM), phagocytic glycoprotein-1 (PgP-1), ECM-III, HUTCH-1, or Hermes-1. CD44 has been implicated in cell migration, in lymphocyte homing, and in tumor metastasis.
Product Description: Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. NCAM (CD56) is reported to express on most neuroectodermal derived cell lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytoma, and neuroblastoma. It is also expressed on some mesodermally derived tumors such as rhabdomyosarcoma and also on natural killer cells.
CD45/T200/LCA Mouse Monoclonal
CD56 Mouse Monoclonal
Clone: SPM496
Catalog No.
Size
Format
Concentrate
Immunogen: Stimulated human leucocytes.
E11100
0.1ml
Concentrate
Concentrate
Application: IHC-P
E11102
0.5ml
Concentrate
Immunogen: Membrane preparation of a small cell lung carcinoma.
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
Ready-to-use
Species Reactivity: Human*
E11104
7.0ml
E11101
7.0ml
Ready-to-use
Catalog No.
Size
Format
E12430
0.1ml
E12432
0.5ml
E12434 E12431
Isotype: Mouse IgG1/k
Clone: 123C3
Species Reactivity: Human* Isotype: Mouse IgG1/k
Control Tissue: Tonsil Cellular Localization: Membrane
Control Tissue: Brain, Neuroblastoma
Human Tonsil stained with anti-CD45/T200/LCA antibody E1243
Human Neuroblastoma stained with anti-CD56 antibody E1110
Cellular Localization: Membrane
Product Description: CD45 leucocyte common antigen (LCA) belongs to a family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines and normal and malignant non-hematopoietic tissues. The intracellular portion of these molecules has protein phosphatase activity and is involved in regulation of transmembrane signals.
Product Description: Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. NCAM (CD56) is reported to express on most neuroectodermal derived cell lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytoma, and neuroblastoma. It is also expressed on some mesodermally derived tumors such as rhabdomyosarcoma and also on natural killer cells.
CD45RA Mouse Monoclonal
CD63 Mouse Monoclonal Clone: SPM504
Catalog No.
Size
Format
Concentrate
Immunogen: Stimulated human leucocytes.
E17510
0.1ml
Concentrate
Immunogen: Recombinant human CD63 protein.
0.5ml
Concentrate
Application: IHC-P
E17512
0.5ml
Concentrate
Application: IHC-P
E16484
1.0ml
Concentrate
E17514
1.0ml
Concentrate
E16481
7.0ml
Ready-to-use
Species Reactivity: Human*
E17511
7.0ml
Ready-to-use
Species Reactivity: Human*
Catalog No.
Size
Format
E16480
0.1ml
E16482
Isotype: Mouse IgG2a
Clone: SPM524
Isotype: Mouse IgG1/k
Control Tissue: Tonsil
Control Tissue: Melanoma
Cellular Localization: Membrane
Cellular Localization: Cytoplasm
Human Tonsil stained with anti-CD45RA antibody E1648
Human Melanoma stained with anti-CD63 antibody E1751
Product Description: CD45 or Leukocyte Common Antigen (LCA/T200) is a membrane sialoglycoprotein. The differential splicing of the exons generates various isoforms. CD45RA is a single chain glycoprotein. It is expressed on appoximately 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive T-cells while CD45RO+ cells are memory T-cells.
Product Description: CD63 is expressed on activated platelets. CD63 is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. It is also present in monocytes and macrophages and is weakly expressed on granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen which is ME491 and to the platelet antigen PTLGP40.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
31
CD68 Rabbit Polyclonal
CD74 Mouse Monoclonal Clone: N/A
Catalog No.
Size
Format
E17420
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide in the internal region of human CD68 protein.
E17422
0.5ml
Concentrate
Immunogen: Recombinant human CD74 protein.
1.0ml
Concentrate
Application: IHC-P
E17424
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
E17421
7.0ml
Ready-to-use
Catalog No.
Size
Format
E19190
0.1ml
Concentrate
E19192
0.5ml
E19194 E19191
Clone: SPM523
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Mouse IgG1/k
Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Cytoplasm
Cellular Localization: Membrane Control Lysate: Ramos Molecular Weight: 35 kDa
Human Tonsil stained with anti-CD68 antibody E1919
Human Tonsil stained with anti-CD74 antibody E1742
Product Description: CD68 is an intracellular glycoprotein mainly expressed on macrophages and monocytes. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is also expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma.
Product Description: Expression of the invariant chain of the HLA-DR antigen (CD74) by B-lymphocytes begins in the pre-B stage but lost before the final differentiation to plasma cells. This antibody is expressed in B-lymphocytes and many B cell lymphomas.
CD68 Rabbit Polyclonal
CD79a Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3180
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide near the C-terminus of human CD68 protein.
M3182
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus region of human CD79a protein.
1.0ml
Concentrate
Application: IHC-P, WB
M3184
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M3181
7.0ml
Ready-to-use
Catalog No.
Size
Format
E19160
0.1ml
Concentrate
E19162
0.5ml
E19164 E19161
Clone: SP18
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: B Cell Lymphoma, Tonsil
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Control Lysate: Raji, SH-SY5Y Molecular Weight: 37 kDa Protein (calculated); 110 kDa (apparent) Human Tonsil stained with anti-CD68 antibody E1916
Human B Cell Lymphoma stained with anti-CD79a antibody M318
Product Description: CD68 is an intracellular glycoprotein mainly expressed on macrophages and monocytes. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is also expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma.
Product Description: A disulphide-linked heterodimer, consisting of CD79a/mb-1 and CD79b/B29 polypeptides, CD79a is non-covalently associated with membrane-bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a first appears at pre B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas.
CD68 Rabbit Polyclonal
CD79a Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2490
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 155-355 of human CD68.
E2492
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human CD79a protein.
1.0ml
Concentrate
Application: WB
E2494
1.0ml
Concentrate
Application: IHC-P, WB
N/A
N/A
Species Reactivity: Human*
E2491
7.0ml
Ready-to-use
Catalog No.
Size
Format
E13920
0.1ml
Concentrate
E13922
0.5ml
E13924 N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: N/A
Control Tissue: B Cell Lymphoma, Tonsil
Cellular Localization: N/A
Cellular Localization: Membrane
Control Lysate: Human Brain
Control Lysate: Raji
Molecular Weight: 38 kDa
Molecular Weight: 44-48 kDa
N/A E1392
Human Tonsil stained with anti-CD79a antibody E249
Product Description: CD68 is an intracellular glycoprotein expressed on macrophages and monocytes. CD68 expression has been demonstrated in T cells, NK cells, liver and renal tubules.
32
Clone: N/A
Product Description: A disulphide-linked heterodimer, consisting of CD79a/mb-1 and CD79b/B29 polypeptides, CD79a is non-covalently associated with membrane-bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a first appears at pre B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies CD95/FAS Rabbit Polyclonal
CD105/Endoglin/TGF 1/3 Receptor Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E4230
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human FAS protein.
E4232
0.5ml
Concentrate
Immunogen: Recombinant protein encoding 26-176 aa of human CD105.
1.0ml
Concentrate
Application: IHC-P
E4234
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E4231
7.0ml
Ready-to-use
Catalog No.
Size
Format
E2500
0.1ml
Concentrate
E2502
0.5ml
E2504 E2501
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Small Intestine
Control Tissue: Tonsil
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Colon stained with anti-CD95/FAS antibody E250
Human Tonsil stained with anti-CD105/Endoglin/TGF 1/3 Receptor antibody E423
Product Description: CD95, also known as FAS, is a transmembrane glycoprotein. It is a member of the nerve growth factor receptor/tumor necrosis factor superfamily. This cell surface molecule mediates receptor-triggered apoptosis. The FAS antigen is expressed on the surface of various cell types, including activated T and B lymphocytes and T lymphoblastoid cell lines.
Product Description: CD105 or endoglin or GP160 is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists as an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial cell marker. CD105 binds to TGF-Beta1 and Beta3 with high affinity but not TGF-Beta2.
CD99 Rabbit Monoclonal
CD117/c-kit Rabbit Monoclonal Clone: SP119
Catalog No.
Size
Format
M3260
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant full length human CD99 protein.
M3262
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to cytoplasmic domain of human CD117 protein.
1.0ml
Concentrate
Application: IHC-P
M3264
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M3261
7.0ml
Ready-to-use
Catalog No.
Size
Format
M4190
0.1ml
Concentrate
M4192
0.5ml
M4194 M4191
Clone: SP26
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Pancreas
Control Tissue: Gastrointestinal Stromal Tumor
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm
Human Pancreas stained with anti-CD99 antibody M419
Human Gastrointestinal Stromal Tumor stained with anti-CD117/c-kit antibody M326
Product Description: CD99, or MIC2 gene product, or E2 antigen is expressed on the cell membrane of some lymphocytes, cortical thymocytes, and granulosa cells of the ovary. The antigen is also expressed by most pancreatic islet cells, Sertoli cells of the testis, and some endothelial cells. Mature granulocytes express very little or no CD99. MIC2 is strongly expressed on Ewing’s sarcoma cells and primitive peripheral neuroectodermal tumors.
Product Description: CD117, also called KIT or c-kit receptor, is a cytokine receptor on the surface of hematopoietic stem cells and other cells. CD117 gene encodes the human homolog of the proto-oncogene c-kit. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, and chronic myelogenous leukemia.
CD99/MIC2 Rabbit Polyclonal
CD117/c-kit Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E1440
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant full length human CD99 protein.
E1442
0.5ml
Concentrate
Immunogen: Synthetic peptide from the cytoplasmic domain of human CD117/c-kit protein.
1.0ml
Concentrate
Application: IHC-P, WB
E1444
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E1441
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3390
0.1ml
Concentrate
E3392
0.5ml
E3394 E3391
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Pancreas
Control Tissue: Gastrointestinal Stromal Tumor
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm
Control Lysate: Jurkat Molecular Weight: 32/28 kDa Human Pancreas stained with anti-CD99/MIC2 antibody E339
Product Description: CD99, or MIC2 gene product, or E2 antigen is expressed on the cell membrane of some lymphocytes, cortical thymocytes, and granulosa cells of the ovary. The antigen is also expressed by most pancreatic islet cells, Sertoli cells of the testis, and some endothelial cells. Mature granulocytes express very little or no CD99. MIC2 is strongly expressed on Ewing’s sarcoma cells and primitive peripheral neuroectodermal tumors.
Human Gastrointestinal Stromal Tumor stained with anti-CD117/c-kit antibody E144
Product Description: CD117, also called KIT or c-kit receptor, is a cytokine receptor on the surface of hematopoietic stem cells and other cells. CD117 gene encodes the human homolog of the proto-oncogene c-kit. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, and chronic myelogenous leukemia.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
33
CD138 Rabbit Polyclonal
CD163 Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3960
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 18-218 human CD138.
M3962
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to near N-terminus of human CD163 protein.
1.0ml
Concentrate
Application: IHC-P
M3964
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M3961
7.0ml
Ready-to-use
Catalog No.
Size
Format
E4560
0.1ml
Concentrate
E4562
0.5ml
E4564 E4561
Clone: SP96
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Lung
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Tonsil stained with anti-CD138 antibody E456
Human Lung stained with anti-CD163 antibody M396
Product Description: CD138/Syndecan-1 is a transmembrane heparin sulphate proteoglycan which is made up of one core protein and five glycosaminoglycan. CD138 is expected to play a role in cell adhesion. It is expressed on the surface of pre-B cells and plasma cells but is absent from mature B cells. It is lost from the apoptotic myeloma cells.
Product Description: CD163, a 130kDa membrane glycoprotein, is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone.
CD146 Rabbit Polyclonal
CD163 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18680
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant human CD146 protein encoding aa 433-647 expressed in E. coli.
E18682
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from near N-terminus of human CD163 protein.
1.0ml
Concentrate
Application: IHC-P
E18684
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E18681
7.0ml
Ready-to-use
Catalog No.
Size
Format
E11130
0.1ml
Concentrate
E11132
0.5ml
E11134 E11131
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Angiosarcoma
Control Tissue: Skin, Thymus
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Angiosarcoma stained with anti-CD146 antibody E1113
Human Skin stained with anti-CD163 antibody E1868
Product Description: CD146, also known as the melanoma cell adhesion molecule (MCAM), is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. CD146 belongs to the immunoglobulin super-gene family with five immunoglobulin like domains (V-V-C2-C2-C2), a transmembrane region and a 63 residue cytoplasmic tail. The protein is a membrane glycoprotein that functions as a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions.
Product Description: CD163, a 130kDa membrane glycoprotein, is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone.
CD150 Rabbit Polyclonal
CD168 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18740
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 1-136 of human CD150.
E18742
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from near C-terminus of human CD168 protein.
1.0ml
Concentrate
Application: WB
E18744
1.0ml
Concentrate
Application: IHC-P
N/A
N/A
Species Reactivity: Human*
E18741
7.0ml
Ready-to-use
Catalog No.
Size
Format
E13940
0.1ml
Concentrate
E13942
0.5ml
E13944 N/A
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: N/A
Control Tissue: Prostate Carcinoma
Cellular Localization: N/A
Cellular Localization: Membrane
Control Lysate: Human Heart Molecular Weight: 37 kDa N/A E1394
Product Description: CD150, designated SLAM (Signaling Lymphocyte Activation Molecule) or CDw150, belongs to the immunoglobulin gene superfamily and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form, and the cytoplasmic isoforms of SLAM.
34
Human Prostate Carcinoma stained with anti-CD168 antibody E1874
Product Description: The CD168 antigen is a non-integral cell surface hyaluronan receptor and intracellular protein. When hyaluronan binds to CD168, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. CD168 activation regulates various cellular processes including cell migration, proliferation, signaling, regulation of gene expression, cell differentiation, morphogenesis, and metastasis.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies CD274/B7-H1 Rabbit Polyclonal
CDC2 p34 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4150
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to near N-terminus of human CD274.
E4152
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E4154
1.0ml
Concentrate
7.0ml
Ready-to-use
Species Reactivity: Human*
E4151
7.0ml
Ready-to-use
Catalog No.
Size
Format
E18360
0.1ml
Concentrate
E18362
0.5ml
E18364 E18361
Clone: N/A Immunogen: Synthetic peptide derived from C-terminus of human CDC2 p34 protein. Application: IHC-P, WB Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung, Skeletal Muscle, Tonsil
Control Tissue: Breast Carcinoma, Tonsil
Cellular Localization: Membrane
Cellular Localization: Nucleus Control Lysate: HeLa Molecular Weight: 34 kDa
Human Tonsil stained with anti-CD274/B7-H1 antibody E1836
Human Tonsil stained with anti-CDC2 p34 antibody E415
Product Description: B7-H1 (B7 homologue 1, PD-L1), expressed on the surface of tumor cells or antigen-presenting cells in the tumor microenvironment, can suppress antitumor activity in immune reaction, promote tumor growth and help tumor cells to escape the immune response. B7-H1 is highly expressed on leukemia cells of acute monocyte leukemia (M5). B7-H1 expression also plays a critical role in the pathogenesis of human gastric carcinoma.
Product Description: In vertebrates, multiple cyclins have been identified, including a total of eight such regulatory proteins in mammals. In contrast to the situation in yeast, the CDC2 p34 kinase is not the only catalytic subunit identified in vertebrates that can interact with cyclins. CDC2 p34 is essential for the G2 to M transition in vertebrate cells. Several additional CDC2 p34-related cyclin dependent kinases have been identified.
CD278/ICOS Rabbit Monoclonal
CDH1 Rabbit Polyclonal
Clone: SP98
Catalog No.
Size
Format
E18830
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human CD278.
E18832
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from near N-terminus of human CDH1 protein.
1.0ml
Concentrate
Application: IHC-P
E18834
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E18831
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3980
0.1ml
Concentrate
M3982
0.5ml
M3984 M3981
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Reactive Lymph Node, Tonsil
Control Tissue: Rectal Carcinoma
Cellular Localization: Membrane
Cellular Localization: Nucleus
Human Reactive Lymph Node stained with anti-CD278/ICOS antibody M398
Human Rectal Carcinoma stained with anti-CDH1 antibody E1883
Product Description: CD278 belongs to the CD28 and CTLA-4 cell-surface receptor family and is highly expressed in activated T cells. It is essential both for efficient interaction between T and B cells and for normal antibody responses to T cell dependent antigens. It enhances all basic T cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells.
Product Description: CDH1 protein is a limiting, substrate-specific activator of anaphase-promoting complex (APC)-dependent proteolysis and is required for the degradation of the APC substrates, such as CIB2 and ASE1. CDH1 plays an important role in mitotic regulation.
CD278/ICOS Rabbit Polyclonal
CDK2 Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3800
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from near C-terminus of human CD278 protein.
M3802
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
M3804
1.0ml
Concentrate
7.0ml
Ready-to-use
Species Reactivity: Human*
M3801
7.0ml
Ready-to-use
Catalog No.
Size
Format
E18650
0.1ml
Concentrate
E18652
0.5ml
E18654 E18651
Clone: SP80 Immunogen: Synthetic peptide corresponding to C-terminus of human CDK2 protein. Application: IHC-P, WB Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Membrane
Cellular Localization: Cytoplasm, Nucleus Control Lysate: HeLa Molecular Weight: 33 kDa
Human Tonsil stained with anti-CD278/ICOS antibody E1865
Product Description: CD278 belongs to the CD28 and CTLA-4 cell-surface receptor family and is highly expressed in activated T cells. It is essential both for efficient interaction between T and B cells and for normal antibody responses to T cell dependent antigens. It enhances all basic T cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells.
Human Tonsil stained with anti-CDK2 antibody M380
Product Description: CDK2 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae CDC28, and S. pombe CDC2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and is essential for cell cycle G1/S phase transition. This protein is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B).
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
35
CDK2 Rabbit Polyclonal
CEA/CD66e Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2970
0.1ml
Concentrate
Immunogen: Purified human CEA.
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human CDK2 protein.
E2972
0.5ml
Concentrate
Concentrate
Application: IHC-P, WB
Application: IHC-P
1.0ml
E2974
1.0ml
Concentrate
7.0ml
Ready-to-use
Species Reactivity: Human*
E2971
7.0ml
Ready-to-use
Species Reactivity: Human*
Catalog No.
Size
Format
E18540
0.1ml
Concentrate
E18542
0.5ml
E18544 E18541
Isotype: Rabbit IgG
Clone: N/A
Isotype: Rabbit IgG Control Tissue: Colon Carcinoma
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Luminal Membrane
Cellular Localization: Cytoplasm, Nucleus Control Lysate: HeLa Molecular Weight: 33 kDa Human Tonsil stained with anti-CDK2 antibody E1854
Human Colon Carcinoma stained with anti-CEA/CD66e antibody E297
Product Description: CDK2 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae CDC28, and S. pombe CDC2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and is essential for cell cycle G1/S phase transition. This protein is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B).
Product Description: Carcinoembryonic antigen (CEA), is synthesized during development in the fetal gut, and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. CEA is expressed in various metastatic adenocarcinomas and in pulmonary adenocarcinomas.
CDX2 Rabbit Monoclonal
CEA/CD66e Mouse Monoclonal Clone: SP54
Catalog No.
Size
Format
E16500
0.1ml
Concentrate
Immunogen: Purified human CEA.
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human CDX2.
E16502
0.5ml
Concentrate
Concentrate
Application: IHC-P
Application: IHC-P
1.0ml
E16504
1.0ml
Concentrate
7.0ml
Ready-to-use
Species Reactivity: Human*
E16501
7.0ml
Ready-to-use
Species Reactivity: Human*
Catalog No.
Size
Format
M3540
0.1ml
Concentrate
M3542
0.5ml
M3544 M3541
Isotype: Rabbit IgG
Clone: SPM506
Isotype: Mouse IgG1 Control Tissue: Colon Carcinoma
Control Tissue: Colon Carcinoma
Cellular Localization: Cytoplasm, Luminal Membrane
Cellular Localization: Nucleus
Human Colon Carcinoma stained with anti-CDX2 antibody M354
Human Colon Carcinoma stained with anti-CEA/CD66e antibody E1650
Product Description: CDX2 encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, colorectal carcinomas, intestinal metaplasia of the stomach, and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa.
Product Description: Carcinoembryonic antigen (CEA), is synthesized during development in the fetal gut, and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. CEA is expressed in various metastatic adenocarcinomas and in pulmonary adenocarcinomas.
CDX2 Rabbit Polyclonal
c-erbB-2 (Paired 1248) Rabbit Polyclonal
Catalog No.
Size
Format
E14180
0.1ml
Concentrate
E14182
0.5ml
Concentrate
E14184
1.0ml
Concentrate
N/A
N/A
N/A
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to N-terminus of human CDX2.
E18480
0.1ml
Concentrate
E18482
0.5ml
Concentrate
E18484
1.0ml
Concentrate
Application: WB
E18481
7.0ml
Ready-to-use
Clone: N/A Immunogen: Synthetic peptide derived from the region of human c-erbB-2 that contains non-phosphorylated tyrosine 1248. Application: IHC-P
Species Reactivity: Human*
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: N/A
Control Tissue: Breast Carcinoma
Cellular Localization: N/A
Cellular Localization: Membrane
Control Lysate: Human Placenta Molecular Weight: 37 kDa N/A E1418
Product Description: CDX2 encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, colorectal carcinomas, intestinal metaplasia of the stomach, and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa.
36
Human Breast Carcinoma stained with anti-c-erbB-2 (Paired 1248) antibody E1848
Product Description: c-erbB-2 is a 185kDa transmembrane tyrosine kinase that belongs to the epidermal growth factor receptor (EGFR) family. This family comprises four homologous receptors: ERFR, c-erbB-2, cerbB-3 and c-erbB-4. Activation of c-erbB-2 through autophosphorylation at tyrosine residues, is initiated by either homo- or heterodimerization and triggers intracellular signaling events. This antibody labels c-cerbB-2 that is non-phosphorylated at 1248 tyrosine residue.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies c-erbB-2 (Phospho Y1248) Rabbit Polyclonal Catalog No.
Size
Format
E18470
0.1ml
Concentrate
E18472
0.5ml
Concentrate
E18474
1.0ml
Concentrate
E18471
7.0ml
Ready-to-use
c-erbB-3/HER-3 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide derived from the region of human c-erbB-2 that contains phosphorylated tyrosine 1248.
M3710
0.1ml
Concentrate
M3712
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human c-erbB-3.
M3714
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
M3711
7.0ml
Ready-to-use
Species Reactivity: Human*
Clone: SP71
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Small Intestine
Control Tissue: Breast Carcinoma
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Breast Carcinoma stained with anti-c-erbB-2 (Phospho Y1248) antibody E1847
Human Small Intestine stained with anti-c-erbB-3/HER-3 antibody M371
Product Description: c-erbB-2 is a 185kDa transmembrane tyrosine kinase belongs to the epidermal growth factor receptor (EGFR) family. This family comprises four homologous receptors: ERFR, c-erbB-2, cerbB-3 and c-erbB-4. Activation of c-erbB-2 through autophosphorylation at tyrosine residues, is initiated by either homo- or heterodimerization and triggers intracellular signaling events. This antibody labels c-cerbB-2 that is non-phosphorylated at 1248 tyrosine residue.
Product Description: The gene for c-erbB-3/HER-3 is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6.2kb mRNA which is translated into a 160/180kDa glycoprotein. The c-erbB-3/HER-3 gene encodes secreted as well as transmembrane receptor tyrosine kinase due to alternative splicing. The c-erbB-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon.
c-erbB-2/HER-2 Rabbit Monoclonal
c-erbB-3/HER-3 Rabbit Polyclonal
Clone: SP3
Catalog No.
Size
Format
E18580
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding extracellular domain of human c-erbB-2.
E18582
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human c-erbB-3 protein.
1.0ml
Concentrate
Application: IHC-P
E18584
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E18581
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3030
0.1ml
Concentrate
M3032
0.5ml
M3034 M3031
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Breast Carcinoma, Colon Carcinoma
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Breast Carcinoma stained with anti-c-erbB-2/HER-2 antibody M303
Human Colon Carcinoma stained with anti-c-erbB-3/HER-3 antibody E1858
Product Description: c-erbB-2 is a receptor tyrosine kinase of the c-erbB family. It is closely related in structure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is detectable in a proportion of breast and other adenocarconomas, as well as transitional cell carcinomas.
Product Description: The gene for c-erbB-3/HER-3 is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6.2kb mRNA which is translated into a 160/180kDa glycoprotein. The c-erbB-3/HER-3 gene encodes secreted as well as transmembrane receptor tyrosine kinase due to alternative splicing. The c-erbB-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon.
c-erbB-2/HER-2 Rabbit Polyclonal
c-erbB-3/HER-3 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17930
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human c-erbB-2 protein.
E17932
0.5ml
Concentrate
Immunogen: Synthetic peptide from near N-terminus of human c-erbB-3 protein.
1.0ml
Concentrate
Application: IHC-P
E17934
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E17931
7.0ml
Ready-to-use
Catalog No.
Size
Format
E2440
0.1ml
Concentrate
E2442
0.5ml
E2444 E2441
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Breast Carcinoma, Colon Carcinoma
Cellular Localization: Membrane
Cellular Localization: Cytoplasm, Membrane
Human Breast Carcinoma stained with anti-c-erbB-2/HER-2 antibody E244
Human Breast Carcinoma stained with anti-c-erbB-3/HER-3 antibody E1793
Product Description: c-erbB-2 is a receptor tyrosine kinase of the c-erbB family. It is closely related in structure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is detectable in a proportion of breast and other adenocarconomas, as well as transitional cell carcinomas.
Product Description: The gene for c-erbB-3/HER-3 is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6.2kb mRNA which is translated into a 160/180kDa glycoprotein. The c-erbB-3/HER-3 gene encodes secreted as well as transmembrane receptor tyrosine kinase due to alternative splicing. The c-erbB-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
37
c-erbB-4/HER-4 Rabbit Polyclonal
Chromogranin A Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3120
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human c-erbB-4 protein.
M3122
0.5ml
Concentrate
Immunogen: Recombinant protein encoding human chromogranin A.
1.0ml
Concentrate
Application: IHC-P, WB
M3124
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M3121
7.0ml
Ready-to-use
Catalog No.
Size
Format
E2760
0.1ml
Concentrate
E2762
0.5ml
E2764 E2761
Clone: SP12
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Pancreas
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm
Control Lysate: A431 Molecular Weight: 140 kDa Human Breast Carcinoma stained with anti-c-erbB-4/HER-4 antibody E276
Human Pancreas stained with anti-Chromogranin A antibody M312
Product Description: c-erbB-4 or HER-4 is the fourth member of the class I receptor kinase family. HER-4 is expressed in normal skeletal muscle, heart, pituitary, cerebellum, and breast. It is specifically bound and activated by neuregulins, NRG-2, NRG-3, heparinbinding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA.
Product Description: Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It has been identified in carcinoid tumors, phenochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
c-Fos Rabbit Polyclonal
Chromogranin A Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E1520
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human c-Fos oncoprotein.
E1522
0.5ml
Concentrate
Immunogen: Recombinant protein encoding human chromogranin A.
1.0ml
Concentrate
Application: IHC-P
E1524
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E1521
7.0ml
Ready-to-use
Catalog No.
Size
Format
E4460
0.1ml
Concentrate
E4462
0.5ml
E4464 E4461
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Skin
Control Tissue: Pancreas
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm
Human Skin stained with anti-c-Fos antibody E446
Human Pancreas stained with anti-Chromogranin A antibody E152
Product Description: The c-Fos proto-oncogene encodes a nuclear phosphoprotein and is a regulator of transcription, forming a complex with the c-Jun proto-oncogene product. Expression of the c-Fos gene is low in most normal adult tissues. However, high levels of expression have been detected in normal skin.
Product Description: Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It has been identified in carcinoid tumors, phenochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
Cholecystokinin (CCK-8) Rabbit Polyclonal
Claudin-1 Rabbit Polyclonal
Catalog No.
Size
Format
E4510
0.1ml
Concentrate
E4512
0.5ml
Concentrate
E4514
1.0ml
Concentrate
E4511
7.0ml
Ready-to-use
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide sulfated cholecystokinin (26-33) amide (sulfated CCK-8).
E3410
0.1ml
Concentrate
E3412
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human claudin-1 peptide.
E3414
1.0ml
Concentrate
Application: IHC-P, WB
Application: IHC-P, WB
E3411
7.0ml
Ready-to-use
Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Stomach
Species Reactivity: Human*, Mouse* Isotype: Rabbit IgG Control Tissue: Breast Carcinoma, Skin
Cellular Localization: Cytoplasm
Cellular Localization: Cell Junction, Cytoplasm, Membrane
Control Lysate: Human Brain
Control Lysate: HeLa
Molecular Weight: 12 kDa
Molecular Weight: 20 kDa
Human Stomach stained with anti-Cholecystokinin (CCK-8) antibody E451
Human Skin stained with anti-Claudin-1 antibody E341
Product Description: Cholecystokinin (CCK) is a neuropeptide hormone and neurotransmitter widely distributed throughout the gastrointestinal (GI) tract and the central nervous system (CNS). Antibodies that react specifically with CCK are useful for the study of the mode of action, differential tissue expression and intracellular and subcellular localization of CCK in the CNS and periphery as well as in neuroendocrine cells of the digestive system.
38
Clone: N/A
Product Description: Claudin 1-18 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact, made up of a network of strands to act as a molecular gasket for preventing the leakage of ions and water between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different claudin composition.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Claudin-3 Rabbit Polyclonal
Claudin-7 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E10590
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of mouse claudin-3.
E10592
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human claudin-7 protein.
1.0ml
Concentrate
Application: IHC-P
E10594
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E10591
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3830
0.1ml
Concentrate
E3832
0.5ml
E3834 E3831
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Small Intestine
Control Tissue: Colon Carcinoma
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm, Membrane
Human Small Intestine stained with anti-Claudin-3 antibody E383
Human Colon Carcinoma stained with anti-Claudin-7 antibody E1059
Product Description: Claudin 1-18 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact, made up of a network of strands to act as a molecular gasket for preventing the leakage of ions and water between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different claudin composition.
Product Description: The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Claudins, which consist of four trans-membrane domains and two extracellular loops, make up tight junction strands.
Claudin-4 Rabbit Polyclonal
Claudin-10 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E10240
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human claudin-4.
E10242
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human claudin-10 protein.
1.0ml
Concentrate
Application: IHC-P
E10244
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E10241
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3980
0.1ml
Concentrate
E3982
0.5ml
E3984 E3981
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Ovarian Carcinoma, Tonsil
Control Tissue: Brain, Skeletal Muscle
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm
Human Ovarian Carcinoma stained with anti-Claudin-4 antibody E398
Human Skeletal Muscle stained with anti-Claudin-10 antibody E1024
Product Description: Claudin 1-18 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact, made up of a network of strands to act as a molecular gasket for preventing the leakage of ions and water between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different claudin composition.
Product Description: The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Claudins, which consist of four trans-membrane domains and two extracellular loops, make up tight junction strands.
Claudin-5 Rabbit Polyclonal
Claudin-11 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E8770
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of mouse claudin-5.
E8772
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human claudin-11 protein.
1.0ml
Concentrate
Application: IHC-P
E8774
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E8771
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3750
0.1ml
Concentrate
E3752
0.5ml
E3754 E3751
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung
Control Tissue: Mouse Brain, Testis
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Membrane
Human Lung stained with anti-Claudin-5 antibody E375
Human Testis stained with anti-Claudin-11 antibody E877
Product Description: Claudin 1-18 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact, made up of a network of strands to act as a molecular gasket for preventing the leakage of ions and water between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different claudin composition.
Product Description: The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Claudin-11 plays a major role in tight junction-specific obliteration of the intercellular space.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
39
c-Met** Rabbit Monoclonal
c-Met (Paired 1003) Rabbit Polyclonal Clone: SP44
Catalog No.
Size
Format
E18110
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human c-Met protein.
E18112
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E18114
1.0ml
Concentrate
7.0ml
Ready-to-use
Species Reactivity: Human*
E18111
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3440
0.1ml
Concentrate
M3442
0.5ml
M3444 M3441
Clone: N/A Immunogen: Synthetic peptide corresponding to the region of c-Met that contains non-phosphorylated tyrosine 1003. Application: IHC-P Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma Cellular Localization: Membrane
Control Tissue: Breast Carcinoma
Human Breast Carcinoma stained with anti-c-Met antibody M344
Human Breast Carcinoma stained with anti-c-Met (Paired 1003) antibody E1811
Cellular Localization: Membrane
Product Description: The c-Met oncogene was originally isolated from human osteogenic sarcoma cell line by transfection analysis in NIH/3T3 cells. The Met proto-oncogene product was identified as a transmembrane receptor-like protein with tyrosine kinase activity that is expressed in many tissues. The c-Met gene product has been identified as the cell surface receptor for hepatocyte growth factor, a plasminogen-like protein thought to be a humoral mediator of liver regeneration.
Product Description: The c-Met oncogene was identified as a transmembrane receptor-like protein with tyrosine kinase activity. The c-Met gene product has been identified as the cell surface receptor for hepatocyte growth factor and is involved in cell proliferation, scattering, morphogenesis, and survival. This antibody labels c-Met that is non-phosphorylated at 1003 tyrosine residue.
c-Met Rabbit Polyclonal
c-Met (Paired 1349) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18130
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human c-Met protein.
E18132
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E18134
1.0ml
Concentrate
7.0ml
Ready-to-use
Species Reactivity: Human*
E18131
7.0ml
Ready-to-use
Catalog No.
Size
Format
E10610
0.1ml
Concentrate
E10612
0.5ml
E10614 E10611
Clone: N/A Immunogen: Synthetic peptide corresponding to the region of c-Met that contains non-phosphorylated tyrosine 1349. Application: IHC-P Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Ovarian Carcinoma Cellular Localization: Cytoplasm, Membrane
Control Tissue: Breast Carcinoma
Human Ovarian Carcinoma stained with anti-c-Met antibody E1061
Human Breast Carcinoma stained with anti-c-Met (Paired 1349) antibody E1813
Cellular Localization: Membrane
Product Description: The c-Met oncogene was originally isolated from human osteogenic sarcoma cell line by transfection analysis in NIH/3T3 cells. The Met proto-oncogene product was identified as a transmembrane receptor-like protein with tyrosine kinase activity that is expressed in many tissues. The c-Met gene product has been identified as the cell surface receptor for hepatocyte growth factor, a plasminogen-like protein thought to be a humoral mediator of liver regeneration.
Product Description: The c-Met oncogene was identified as a transmembrane receptor-like protein with tyrosine kinase activity. The c-Met gene product has been identified as the cell surface receptor for hepatocyte growth factor and is involved in cell proliferation, scattering, morphogenesis, and survival. This antibody labels c-Met that is non-phosphorylated at 1003 tyrosine residue.
c-Met (Paired 1003) Rabbit Monoclonal
c-Met (Phospho Y1003) Rabbit Monoclonal
Catalog No.
Size
Format
M3590
0.1ml
Concentrate
M3592
0.5ml
Concentrate
M3594
1.0ml
Concentrate
M3591
7.0ml
Ready-to-use
Clone: SP59
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to the region of c-Met that contains non-phosphorylated tyrosine 1003.
M3580
0.1ml
Concentrate
M3582
0.5ml
Concentrate
M3584
1.0ml
Concentrate
Application: IHC-P
M3581
7.0ml
Ready-to-use
Immunogen: Synthetic peptide corresponding to the region of c-Met that contains phosphorylated tyrosine 1003. Application: IHC-P
Species Reactivity: Human*
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Breast Carcinoma stained with anti-c-Met (Paired 1003) antibody M359
Human Breast Carcinoma stained with anti-c-Met (Phospho Y1003) antibody M358
Product Description: The c-Met oncogene was identified as a transmembrane receptor-like protein with tyrosine kinase activity. The c-Met gene product has been identified as the cell surface receptor for hepatocyte growth factor and is involved in cell proliferation, scattering, morphogenesis, and survival. This antibody labels c-Met that is non-phosphorylated at 1003 tyrosine residue.
40
Clone: SP58
Product Description: The c-Met oncogene was identified as a transmembrane receptor-like protein with tyrosine kinase activity. It is a cell surface receptor for hepatocyte growth factor and involves in cell proliferation, scattering, morphogenesis, and survival. This antibody is specific for Met (c-Met), only when phosphorylated at tyrosine 1003.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies c-Met (Phospho Y1003) Rabbit Polyclonal Catalog No.
Size
Format
E18100
0.1ml
Concentrate
E18102
0.5ml
Concentrate
E18104
1.0ml
Concentrate
E18101
7.0ml
Ready-to-use
Connexin-43 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to the region of c-Met that contains phosphorylated tyrosine 1003.
E2740
0.1ml
Concentrate
E2742
0.5ml
Concentrate
E2744
1.0ml
Concentrate
Application: IHC-P
E2741
7.0ml
Ready-to-use
Clone: N/A Immunogen: Synthetic peptide derived from a segment of the 3rd cytoplasmic domain of rat connexin-43. Application: IHC-P, WB
Species Reactivity: Human*
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Heart
Cellular Localization: Membrane
Cellular Localization: Cytoplasm Control Lysate: MCF7 Molecular Weight: 43 kDa
Human Breast Carcinoma stained with anti-c-Met (Phospho Y1003) antibody E1810
Human Heart stained with anti-Connexin-43 antibody E274
Product Description: The c-Met oncogene was identified as a trans-membrane receptor-like protein with tyrosine kinase activity. It is a cell surface receptor for hepatocyte growth factor and involves in cell proliferation, scattering, morphogenesis, and survival. This antibody is specific for Met (c-Met), only when phosphorylated at tyrosine 1003.
Product Description: The connexins are a group of gap junction proteins which form a hexamer to compose a connexon. Clusters of connexins form a gap junction through which low molecular weight proteins may diffuse from cell to cell. Connexins are also thought to be essential for the development of labor contractions.
c-Met (Phospho Y1234/1235) Rabbit Polyclonal
Corticotropin Releasing Factor (CRF) Rabbit Polyclonal
Catalog No.
Size
Format
E18140
0.1ml
Concentrate
E18142
0.5ml
Concentrate
E18144
1.0ml
Concentrate
E18141
7.0ml
Ready-to-use
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to the region of c-Met that contains phosphorylated tyrosine 1234/1235.
E10250
0.1ml
Concentrate
E10252
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human CRF protein.
E10254
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
E10251
7.0ml
Ready-to-use
Species Reactivity: Human*
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain, Placenta
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Membrane
Human Breast Carcinoma stained with anti-c-Met (Phospho Y1234/1235) antibody E1814
Human Brain stained with anti-Corticotropin Releasing Factor (CRF) antibody E1025
Product Description: The c-Met oncogene was originally isolated from human osteogenic sarcoma cell line by transfection analysis in NIH/3T3 cells. The c-Met protein was identified as a trans-membrane receptor-like protein with tyrosine kinase activity. It is a cell surface receptor for hepatocyte growth factor and involves in cell proliferation, scattering, morphogenesis, and survival. This antibody is specific for Met (c-Met), only when phosphorylated at tyrosine 1234 and 1235.
Product Description: Corticotropin Releasing Factor (CRF), a 41 amino acids neuropeptide, belongs to a family of structurally related peptides including urocortin, sauvagine and urotensin I. CRF is critical in the regulation of the pituitary-adrenal gland axis, and in endocrine, autonomic and behavioral responses to stress. CRF is widely distributed in the brain and peripheral nervous system with the highest levels in the hypothalamic paraventricular nucleus.
c-Met (Phospho Y1349) Rabbit Polyclonal
COX-1 Rabbit Polyclonal
Catalog No.
Size
Format
E18120
0.1ml
Concentrate
E18122
0.5ml
Concentrate
E18124
1.0ml
Concentrate
E18121
7.0ml
Ready-to-use
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to the region of c-Met that contains phosphorylated tyrosine 1349.
E14310
0.1ml
Concentrate
E14312
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human COX-1.
E14314
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
E14311
7.0ml
Ready-to-use
Species Reactivity: Human*
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Esophageal Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Membrane
Human Breast Carcinoma stained with anti-c-Met (Phospho Y1349) antibody E1812
Product Description: The c-Met oncogene was originally isolated from human osteogenic sarcoma cell line by transfection analysis in NIH/3T3 cells. The c-Met protein was identified as a trans-membrane receptor-like protein with tyrosine kinase activity. It is a cell surface receptor for hepatocyte growth factor and involves in cell proliferation, scattering, morphogenesis, and survival. This antibody is specific for Met (c-Met), only when phosphorylated at tyrosine 1349.
Clone: N/A
Human Esophageal Carcinoma stained with anti-COX-1 antibody E1431
Product Description: Cyclooxygenases 1 and 2 (COX-1, COX-2) are enzymes involved in the conversion of arichidonate to prostaglandins. COX-1 and COX-2 are very similar in structure and function, though they vary in expression. COX-1 is normally expressed in most cell types, whereas COX-2 expression is at low levels unless induced by hormonal stimuli. In some breast cancer and bladder carcinoma studies, COX-1 was expressed in the stroma cells adjacent to the tumors but not in tumor cells.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
41
COX-2 Rabbit Monoclonal
Cripto-1 Rabbit Polyclonal Clone: SP21
Catalog No.
Size
Format
E18430
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of rat COX-2.
E18432
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from human cripto-1.
1.0ml
Concentrate
Application: IHC-P
E18434
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E18431
7.0ml
Ready-to-use
Catalog No.
Size
Format
M3210
0.1ml
Concentrate
M3212
0.5ml
M3214 M3211
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Colon, Lung
Control Tissue: Colon Carcinoma
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Membrane
Human Breast Carcinoma stained with anti-COX-2 antibody M321
Human Colon Carcinoma stained with anti-Cripto-1 antibody E1843
Product Description: COX2 (Cyclooxygenase-2 COX2) is an inducible enzyme in response to growth factors, tumor promoters, and cytokines. COX2 is induced by a wide variety of stimuli and was initially identified as immediate-early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.
Product Description: The cripto gene is expressed both in embryonic stem cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers. The expression of Cripto-1 may represent a useful marker to identify cancer stem cells in melanoma, and possibly other aggressive tumors as well. Caveolin-1 can be down-regulated during the process of Cripto-1 mediated tumorigenesis in the mammary gland.
COX-2 Rabbit Polyclonal
c-TEN Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3830
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of rat COX-2.
M3832
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human c-TEN protein.
1.0ml
Concentrate
Application: IHC-P
M3834
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
M3831
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3030
0.1ml
Concentrate
E3032
0.5ml
E3034 E3031
Clone: SP83
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Colon, Lung
Control Tissue: Liver Carcinoma
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm, Membrane
Human Breast Carcinoma stained with anti-COX-2 antibody E303
Human Liver Carcinoma stained with anti-c-TEN antibody M383
Product Description: COX2 (Cyclooxygenase-2 COX2) is an inducible enzyme in response to growth factors, tumor promoters, and cytokines. COX2 is induced by a wide variety of stimuli and was initially identified as immediate-early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.
Product Description: c-TEN/TNS4 links the focal adhesion and cell adhesion signaling to the actin cytoskeleton. It may be involved in cell survival and migration. The protein may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton and promote apoptosis, via its cleavage by caspase-3.
CREB-Binding Protein (CBP ) Rabbit Polyclonal
c-TEN Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18190
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to aa 2422-2441 of human CBP.
E18192
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human c-TEN protein.
1.0ml
Concentrate
Application: IHC-P
E18194
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E18191
7.0ml
Ready-to-use
Catalog No.
Size
Format
E13840
0.1ml
Concentrate
E13842
0.5ml
E13844 E13841
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Colon Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm, Membrane
Human Tonsil stained with anti-CREB-Binding Protein (CBP ) antibody E1384
Human Colon Carcinoma stained with anti-c-TEN antibody E1819
Product Description: CBP (CREB-binding protein) is a 265kDa nuclear protein which probably has many of the properties expected of a CREB co-activator. It shows substantial sequence homology with p300.
42
Clone: SP58
Product Description: c-TEN/TNS4 links the focal adhesion and cell adhesion signaling to the actin cytoskeleton. It may be involved in cell survival and migration. The protein may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton and promote apoptosis, via its cleavage by caspase-3.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Cullin-1 (CUL-1) Rabbit Polyclonal
Cyclin B1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4100
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human cullin-1.
E4102
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human cyclin B1 protein.
1.0ml
Concentrate
Application: IHC-P
E4104
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E4101
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3790
0.1ml
Concentrate
E3792
0.5ml
E3794 E3791
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma, Tonsil
Control Tissue: Breast Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm, Nucleus
Human Colon Carcinoma stained with anti-Cullin-1 (CUL-1) antibody E379
Human Breast Carcinoma stained with anti-Cyclin B1 antibody E410
Product Description: Cullin-1 (CUL-1) is a member of the family of human cullin genes (cullin-1, 2, 3, 4a, 4b, and 5) homologous to the S. cerevisiae cdc53 gene. Cullin-1 forms a complex with human p19skp1 and F box protein p45skp2, both of which, together with cdc53, as three subunits, form an ubiquitin ligase controlling proteolysis of G1 cell cycle regulatory proteins. The cullin-1/p19skp1/p45skp2 complex is thought to play a role in the ubiquitination of G1 regulatory proteins.
Product Description: Cyclin B1 is a regulatory protein involved in mitosis. Cyclin B1 associates with inactive p34 (cdc2) to facilitate phosphorylation of p34 (cdc2) at aa 14Thr and 15Tyr. Cyclin B1 is expressed predominantly during G2/M phase of the cell cycle. The cyclin B1-p34 (cdc2) complex plays a critical role in G2 to M transition. Cyclin B1 also contributes to the switch-like all or none behavior of the cell in deciding to commit to mitosis.
Cullin-2 (CUL-2) Rabbit Polyclonal
Cyclin D1 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3040
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human cullin-2.
M3042
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human cyclin D1.
1.0ml
Concentrate
Application: IHC-P
M3044
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
M3041
7.0ml
Ready-to-use
Catalog No.
Size
Format
E4160
0.1ml
Concentrate
E4162
0.5ml
E4164 E4161
Clone: SP4
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Mantle Cell Lymphoma, Tonsil
Cellular Localization: Nucleus
Cellular Localization: Nucleus Control Lysate: MCF7 Molecular Weight: 36 kDa
Human Tonsil stained with anti-Cullin-2 (CUL-2) antibody E416
Human Mantle Cell Lymphoma stained with anti-Cyclin D1 antibody M304
Product Description: Cullin-2 (CUL-2) is a member of human cullin gene family (CUL-1, -2, -3, -4a, -4b, and -5). It is the core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes. The ECS ligase complexes mediate the ubiquitination of target proteins such as hypoxia-inducible factor (HIF).
Product Description: Cyclin D1 or PRAD-1 or BCL-1 is one of the key cell cycle regulators, and functions in association with CDK4 and / or CDK6 by phosphorylating the Rb protein. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL).
CXCR4 Rabbit Polyclonal
Cyclin D1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E1540
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from the human CXCR4.
E1542
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human cyclin D1.
1.0ml
Concentrate
Application: IHC-P
E1544
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
E1541
7.0ml
Ready-to-use
Catalog No.
Size
Format
E18440
0.1ml
Concentrate
E18442
0.5ml
E18444 E18441
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta
Control Tissue: Mantle Cell Lymphoma, Tonsil
Cellular Localization: Membrane
Cellular Localization: Nucleus Control Lysate: MCF7 Molecular Weight: 36 kDa
Human Placenta stained with anti-CXCR4 antibody E1844
Product Description: CXCR4 is a principal coreceptor for T cell tropic strains of HIV1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV1 and mediates CD4 independent infection by HIV2. The chemokine SDF1 is the ligand for CXCR4 and prevents infection by T tropic HIV1. CXCR4 is highly expressed in brain and heart, and in white blood cells, vascular endothelial cells, and umbilical cord endothelial cells.
Human Mantle Cell Lymphoma stained with anti-Cyclin D1 antibody E154
Product Description: Cyclin D1 or PRAD-1 or BCL-1 is one of the key cell cycle regulators, and functions in association with CDK4 and / or CDK6 by phosphorylating the Rb protein. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL).
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
43
Cyclin E Rabbit Polyclonal
D4-GDI Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2430
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human cyclin E.
E2432
0.5ml
Concentrate
Immunogen: Recombinant full-length human D4-GDI protein.
1.0ml
Concentrate
Application: IHC-P
E2434
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-use
Species Reactivity: Human*
E2431
7.0ml
Ready-to-use
Catalog No.
Size
Format
E3600
0.1ml
Concentrate
E3602
0.5ml
E3604 E3601
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Placenta
Control Tissue: Placenta, Tonsil
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm, Nucleus Control Lysate: Jurkat Molecular Weight: 23 kDa
Human Breast Carcinoma stained with anti-Cyclin E antibody E360
Human Placenta stained with anti-D4-GDI antibody E243
Product Description: Cyclin E is a regulatory subunit of CDK-2 and controls G1/S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post-transcriptional regulation of Cyclin E. In vitro analysis indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1.
Product Description: D4-GDI belongs to the family of Rho-GDIs or GDP-dissociation inhibitors for the Rho/Rac family of small G proteins; consisting of RhoGDI-1, D4-GDI/ RhoGDI-2 and RhoGDI-3. It inhibits the release of GDP from the Rho proteins, essential for GTP-loading and activation of GTPase activity. D4- GDI is located in the cytoplasm and is involved in the regulation of the membrane association and dissociation cycle of Rho/Rac proteins.
CYR61 Rabbit Polyclonal
D5DR Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E12580
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human CYR61.
E12582
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to aa 459-477 of human D5DR.
1.0ml
Concentrate
Application: IHC-P
E12584
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E12581
7.0ml
Ready-to-use
Catalog No.
Size
Format
E18300
0.1ml
Concentrate
E18302
0.5ml
E18304 E18301
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Placenta
Control Tissue: Brain
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Human Colon stained with anti-CYR61 antibody E1830
Human Brain stained with anti-D5DR antibody E1258
Product Description: CYR61 is a secreted cysteine-rich heparin binding protein, encoded by a growth factor inducible immediate-early gene. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins. As an angiogenic inducer, CYR61 binds to the cell surface receptor to promotes DNA synthesis of human vascular endothelial cells. CYR61 is also detected in a wide variety of tumors as it induces tumor growth.
Product Description: The dopamine receptors are divided into two classes, D1 and D2, which differ in their functional characteristics. D1DR and D5DR compose the D1 class of dopamine receptors, and D2DR, D3DR and D4DR compose the D2 class. D1 receptors stimulate adenylyl cyclase, while D2 receptors inhibit adenylyl cyclase activity.
Cytochrome C Rabbit Polyclonal
DAPK2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E16860
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant full length human cytochrome C protein.
E16862
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human DAPK2 protein.
1.0ml
Concentrate
Application: IHC-P
E16864
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-use
Species Reactivity: Human*
E16861
7.0ml
Ready-to-use
Catalog No.
Size
Format
E12410
0.1ml
Concentrate
E12412
0.5ml
E12414 E12411
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Brain stained with anti-Cytochrome C antibody E1241
Human Breast Carcinoma stained with anti-DAPK2 antibody E1686
Product Description: Cytochrome C is an electron transporting protein that resides within the inter-membrane space of the mitochondria, where it plays a critical role in the process of oxidative phosphorylation and production of cellular ATP. Cytocrome C is up-regulated and it is rapidly released from the mitochondria into the cytosol in apoptotic processes. Cytosolic cytochrome C participates in the activation of apoptotic effectors such as caspase-3 and ICE family molecule.
44
Clone: N/A
Product Description: Death-associated protein kinase 2 (DAPK2) is a protein belonging to the serine/threonine protein kinase family. It is pro-apoptotic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFN gamma induced apoptosis. The messenger RNA of DAPK2 is expressed in multiple human tissues.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Desmin Rabbit Polyclonal
DJ-1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E8760
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide mapping near the C-terminus of human desmin.
E8762
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human DJ-1 protein.
1.0ml
Concentrate
Application: IHC-P
E8764
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E8761
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2570
0.1ml
Concentrate
E2572
0.5ml
E2574 E2571
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Sarcoma, Skeletal Muscle
Control Tissue: Breast
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Nucleus Control Lysate: Jurkat Molecular Weight: 22 kDa
Human Skeletal Muscle stained with anti-Desmin antibody E257
Human Breast stained with anti-DJ-1 antibody E876
Product Description: Desmin is an intermediate filament protein of both smooth and striated muscles. Antibody to desmin reacts with striated (skeletal and cardiac) as well as smooth muscle cells. In skeletal and cardiac muscles, the staining is confined to the Z-bands giving a characteristic striated appearance.
Product Description: DJ-1 protein has 189 amino acids and was cloned from a HeLa cell cDNA library as a novel oncogene which weakly transformed NIH3T3 cells. The expression of DJ-1 is induced by growth signals and is translocated from the cytoplasm to the nucleus during the S phase, although no nuclear localization signals are present. It has been suggested that DJ-1 is a mitogen-dependent oncogene product involved in Ras-related signal transduction pathway.
DFF-45 Rabbit Polyclonal
DOG-1 Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3310
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human DFF-45 protein.
M3312
0.5ml
Concentrate
Immunogen: Synthetic peptide of human DOG-1 protein.
1.0ml
Concentrate
Application: IHC-P
M3314
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3311
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3900
0.1ml
Concentrate
E3902
0.5ml
E3904 E3901
Clone: SP31
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma
Control Tissue: Gastrointestinal Stromal Tumor
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Human Colon Carcinoma stained with anti-DFF-45 antibody E390
Human Gastrointestinal Stromal Tumor stained with anti-DOG-1 antibody M331
Product Description: DFF45 and DFF40 (ICAD and CAD) are two subunits of heterodimeric caspase activated DNAse. DFF45/ ICAD (Inhibitor of Caspase Activated DNAse) acts as a chaperon for appropriate folding of DFF40 and it also acts as inhibitor of DFF40. The activation of caspase 3 cleaves DFF to release DFF40/CAD, which oligomerizes into a large active complex and eventually causes the degradation of DNA in nuclei. Hence cleavage of DFF45 is an important step in apoptosis.
Product Description: DOG-1, a novel marker, is expressed ubiquitously in gastrointestinal stromal tumors (GIST) irrespective of KIT or PDGFR alpha mutation status.
DHFR Rabbit Polyclonal
DOG-1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E16710
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human DHFR.
E16712
0.5ml
Concentrate
Immunogen: Synthetic peptide of human DOG-1 protein.
1.0ml
Concentrate
Application: IHC-P
E16714
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E16711
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18220
0.1ml
Concentrate
E18222
0.5ml
E18224 E18221
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Gastrointestinal Stromal Tumor
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Cytoplasm, Membrane
Human Breast Carcinoma stained with anti-DHFR antibody E1822
Human Gastrointestinal Stromal Tumor stained with anti-DOG-1 antibody E1671
Product Description: Dihydrofolate reductase (DHFR) converts dihydrofolate into tetrahydrofolate, and is required for the synthesis of purines, thymidylic acid and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
Product Description: DOG-1, a novel marker, is expressed ubiquitously in gastrointestinal stromal tumors (GIST) irrespective of KIT or PDGFR alpha mutation status.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
45
DOK-1 Rabbit Polyclonal
Dysferlin Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2670
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human DOK-1 protein.
E2672
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human dysferlin.
1.0ml
Concentrate
Application: IHC-P
E2674
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2671
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16830
0.1ml
Concentrate
E16832
0.5ml
E16834 E16831
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Skeletal Muscle
Cellular Localization: Membrane
Cellular Localization: Cytoplasm, Membrane Control Lysate: Human Skeletal Muscle Molecular Weight: ~231 kDa
Human Breast Carcinoma stained with anti-DOK-1 antibody E1683
Human Skeletal Muscle stained with anti-Dysferlin antibody E267
Product Description: DOK-1 (P62dok, Docking protein 1) is believed to be a mainly cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. DOK-1 is a major substrate for many tyrosine kinases including c-kit, v-abl, vFPS, EGF, and PDGF. Upon phosphorylation by kinases, DOK-1 forms a complex with ras GTPase-activating protein.
Product Description: Dysferlin is the protein product of the 2p13 gene that is defective in patients with Limb-Girdle muscular dystrophy type 2B (LGMD2B) and Miyoshi Myopathy (MM). Dysferlin is normally localized to the muscle plasma membrane. In patients with LGMD2B and MM, immunoreactivity to dysferlin is severely reduced or lost, depending on the type of mutation.
DOK-2 Rabbit Polyclonal
Dystrophin Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2660
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human DOK-2 protein.
E2662
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human dystrophin.
1.0ml
Concentrate
Application: IHC-P
E2664
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2661
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16730
0.1ml
Concentrate
E16732
0.5ml
E16734 E16731
Clone: N/A
Species Reactivity: Human*, Mouse*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Skeletal Muscle
Cellular Localization: Cytoplasm
Cellular Localization: Membrane Control Lysate: Human Skeletal Muscle Molecular Weight: 427 kDa
Human Breast Carcinoma stained with anti-DOK-2 antibody E1673
Human Skeletal Muscle stained with anti-Dystrophin antibody E266
Product Description: Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. DOK-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. DOK-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung.
Product Description: Dystrophin is a member of the spectrin/alpha-actinin family of actin-binding, triple helix rod-containing proteins. It is absent or greatly reduced in individuals with the X-linked recessive Duchenne’s muscular dystrophy disorder, as well as in mice with the mdx (murine muscular dystrophy) mutation. This antibody is highly specific to dystrophin and shows no cross-reaction with C-protein (an isoform of α-actinin), α-actin, or human muscle spectrin.
DRAK2 Rabbit Polyclonal
Dystrophin Mouse Monoclonal Clone: N/A
Catalog No.
Size
Format
E14010
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human DRAK2 protein.
E14012
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human dystrophin.
1.0ml
Concentrate
Application: IHC-P
E14014
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E14011
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16750
0.1ml
Concentrate
E16752
0.5ml
E16754 E16751
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Mouse IgG1/k
Control Tissue: Breast Carcinoma
Control Tissue: Skeletal Muscle
Cellular Localization: Nucleus
Cellular Localization: Membrane
Human Breast Carcinoma stained with anti-DRAK2 antibody E1675
Human Skeletal Muscle stained with anti-Dystrophin antibody E1401
Product Description: Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosisinducing protein kinases). DRAKs contain a N-terminal kinase domain and a C-terminus regulation domain. Overexpression of DRAK2 induces apoptosis. DRAK2 is located in nucleus and its mRNA is ubiquitously expressed in human tissue.
46
Clone: SPM499
Product Description: Dystrophin is a member of the spectrin/alpha-actinin family of actin-binding, triple helix rod-containing proteins. It is absent or greatly reduced in individuals with the X-linked recessive Duchenne’s muscular dystrophy disorder, as well as in mice with the mdx (murine muscular dystrophy) mutation. This antibody is highly specific to dystrophin and shows no cross-reaction with C-protein (an isoform of α-actinin), α-actin, or human muscle spectrin.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies E2F-2 Rabbit Polyclonal
Epidermal Growth Factor Receptor (EGFR) Rabbit Monoclonal
Catalog No.
Size
Format
E13610
0.1ml
Concentrate
E13612
0.5ml
Concentrate
E13614
1.0ml
Concentrate
N/A
N/A
N/A
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to N-terminus of human E2F-2.
M3840
0.1ml
Concentrate
M3842
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human EGFR protein.
M3844
1.0ml
Concentrate
Application: WB
Application: IHC-P, WB
M3841
7.0ml
Ready-to-Use
Species Reactivity: Human*
Clone: SP84
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG Control Tissue: N/A
Control Tissue: Lung Squamous Cell Carcinoma
Cellular Localization: N/A
Cellular Localization: Membrane
Control Lysate: HepG2
Control Lysate: A431
Molecular Weight: 48 kDa
Molecular Weight: 175 kDa
E1361
Human Lung Squamous Cell Carcinoma stained with anti-Epidermal Growth Factor Receptor (EGFR) antibody M384
Product Description: E2F transcription factors are functionally regulated by binding to Rb p110, p107, and p130. E2F-2 is regulated by complex formation with Rb p110. E2F family members bind DNA as heterodimers with members of the DP family of polypeptides.
Product Description: EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3, -4 or HER-1, -2, -3, -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-alpha (TGF-alpha), Heparin-binding EGF (HBEGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head, neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
EGFL7 Rabbit Polyclonal
Epidermal Growth Factor Receptor (EGFR) Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3090
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to an internal region of human EGFL7 protein.
M3092
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human EGFR protein.
1.0ml
Concentrate
Application: IHC-P
M3094
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3091
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19130
0.1ml
Concentrate
E19132
0.5ml
E19134 E19131
Clone: SP9
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta
Control Tissue: Lung, Placenta
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm, Membrane
Human Placenta stained with anti-EGFL7 antibody E1913
Human Placenta stained with anti-Epidermal Growth Factor Receptor (EGFR) antibody M309
Product Description: Epidermal growth factor-like protein 7 (EGFL7), also known as VEstatin, MEGF7, Notch4-like protein or Zneu1, is a 29.6 kDa protein produced and secreted by endothelium. The protein is also expressed by some normal and malignant tissues. The main function of EGFL7 is to regulate angiogenesis and vasculogenesis. A high level of EFGL-7 can be found in tissues with active angiogenesis of a variety of disorders.
Product Description: EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3, -4 or HER-1, -2, -3, -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-alpha (TGF-alpha), Heparin-binding EGF (HBEGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head, neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Ephrin A4 Rabbit Polyclonal
Epidermal Growth Factor Receptor (EGFR) Mouse Monoclonal Clone: N/A
Catalog No.
Size
Format
E6690
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant full length human ephrin A4 protein.
E6692
0.5ml
Concentrate
Immunogen: Extracellular domain of human recombinant EGFR protein.
1.0ml
Concentrate
Application: IHC-P
E6694
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E6691
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E11150
0.1ml
Concentrate
E11152
0.5ml
E11154 E11151
Clone: SPM341
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Mouse IgG1
Control Tissue: Brain Cellular Localization: Cytoplasm, Membrane
Control Tissue: Placenta, Skin, Squamous Cell Carcinoma
Human Brain stained with anti-Ephrin A4 antibody E1115
Human Placenta stained with anti-Epidermal Growth Factor Receptor (EGFR) antibody E669
Product Description: Ephrin-A4, also known as LERK-4 or ELF-4, is a ligand for the erythropoietin-producing hepatocellular (Eph) receptor family of tyrosine kinases and it binds EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, and EphB1. Ephrin-A4 interacts with activated B lymphocytes and dendritic cells and it is expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney.
Cellular Localization: Membrane
Product Description: EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3, -4 or HER-1, -2, -3, -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-alpha (TGF-alpha), Heparin-binding EGF (HBEGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head, neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
47
Epidermal Growth Factor Receptor (EGFR) Rabbit Polyclonal
ERCC1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18890
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human EGFR protein.
E18892
0.5ml
Concentrate
Immunogen: Recombinant human ERCC1 protein.
1.0ml
Concentrate
Application: IHC-P, WB
E18894
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18891
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18170
0.1ml
Concentrate
E18172
0.5ml
E18174 E18171
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Esophageal Carcinoma, Placenta
Control Tissue: Lung Squamous Cell Carcinoma, Rectal Carcinoma
Cellular Localization: Membrane
Cellular Localization: Nucleus
Control Lysate: A431
Control Lysate: HeLa
Molecular Weight: 170 kDa
Molecular Weight: 39 kDa
Human Esophageal Carcinoma stained with antiEpidermal Growth Factor Receptor (EGFR) antibody E1817
Human Lung Squamous Cell Carcinoma stained with anti-ERCC1 antibody E1889
Product Description: EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3, -4 or HER-1, -2, -3, -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-alpha (TGF-alpha), Heparin-binding EGF (HBEGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head, neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Product Description: The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to S. cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. The NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3’ of the DNA lesion while the ERCC1-XPF complex makes the 5’ incision.
ERAB Rabbit Polyclonal
ERCC1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18550
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human ERAB protein.
E18552
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human ERCC1 protein.
1.0ml
Concentrate
Application: IHC-P
E18554
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18551
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10320
0.1ml
Concentrate
E10322
0.5ml
E10324 E10321
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Alzheimer’s Brain, Tonsil
Control Tissue: Colon
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus
Human Alzheimer’s Brain stained with anti-ERAB antibody E1032
Human Colon stained with anti-ERCC1 antibody E1855
Product Description: ERAB also known as 3-hydroxyacyl-CoA dehydrogenase type-2 belongs to the short-chain dehydrogenases/reductases (SDR) family. It is one of the mutated genes associated with early onset Alzheimer’s disease. It is shown to be expressed at high levels in Alzheimer’s disease-affected brain and may be related to neuronal dysfunction in Alzheimer’s disease.
Product Description: The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to S. cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. The NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3’ of the DNA lesion while the ERCC1-XPF complex makes the 5’ incision.
ERCC1 Rabbit Monoclonal
ERK-1 Rabbit Polyclonal Clone: SP68
Catalog No.
Size
Format
Concentrate
Immunogen: Recombinant human ERCC1 protein.
E3560
0.1ml
Concentrate
Concentrate
Application: IHC-P
E3562
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human ERK-1 protein.
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
Ready-to-Use
Species Reactivity: Human*
E3564
7.0ml
E3561
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3680
0.1ml
M3682
0.5ml
M3684 M3681
Isotype: Rabbit IgG Control Tissue: Colon, Non-Small Cell Lung Carcinoma
Species Reactivity: Human* Isotype: Rabbit IgG
Cellular Localization: Nucleus
Control Tissue: Breast Carcinoma
Human Lung Carcinoma stained with anti-ERCC1 antibody M368
Human Breast Carcinoma stained with anti-ERK-1 antibody E356
Product Description: The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to S. cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. The NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3’ of the DNA lesion while the ERCC1-XPF complex makes the 5’ incision.
48
Clone: N/A
Cellular Localization: Cytoplasm
Product Description: ERK-1/extracellular signal-regulated kinase 1/p44 MAP kinase/ microtubule-associated protein 2 kinase/myelin basic protein kinase/EGF receptor T669 kinase is ubiquitously expressed in various tissues and cells. It gets activated by phosphorylation of neighboring serine and threonine residues by MEK-1 and MEK-2 in response to diverse stimuli like growth factors and mitogens.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies ERK-2 Rabbit Polyclonal
Estrogen Receptor (ER) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E1640
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of mouse ERK-2 protein.
E1642
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human estrogen receptor.
1.0ml
Concentrate
Application: IHC-P
E1644
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E1641
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3970
0.1ml
Concentrate
E3972
0.5ml
E3974 E3971
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Nucleus
Human Breast Carcinoma stained with anti-ERK-2 antibody E397
Human Breast Carcinoma stained with anti-Estrogen Receptor (ER) antibody E164
Product Description: Extracellular signal-regulated kinase 2 (ERK-2) is a serine-threonine kinase phosphorylates microtubule associated protein-2 and myelin basic protein. This kinase is an important proximal component of the MAP kinase pathway involved in transmitting the signals from growth factors, neurotransmitters and hormones at the cell surface to the transcriptional events in the nucleus.
Product Description: This antibody recognizes a protein of 67kDa, which is identified as estrogen receptor (ER). This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland.
ESA/Ep-CAM Mouse Monoclonal
EZH2 Rabbit Polyclonal
Clone: SPM491
Catalog No.
Size
Format
E19090
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant human ESA protein expressed in E. coli.
E19092
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human EZH2 protein.
1.0ml
Concentrate
Application: IHC-P
E19094
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E19091
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E11170
0.1ml
Concentrate
E11172
0.5ml
E11174 E11171
Clone: N/A
Species Reactivity: Human*
Isotype: Mouse IgG1/k
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Prostate Carcinoma
Cellular Localization: Membrane
Cellular Localization: Nucleus
Human Breast Carcinoma stained with anti-ESA/Ep-CAM antibody E1117
Human Prostate Carcinoma stained with anti-EZH2 antibody E1909
Product Description: EGP40 is a 40kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas.
Product Description: KMT6 / Enhancer of zeste homologue 2 (EZH2) is a histone lysine methyl transferase which is associated with transcriptional repression. EZH2 is ubiquitously expressed during early embryo genesis, and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. The expression of EZH2 is highly expressed in follicular T cells and a variety of tumors including lymphoma, breast and prostate cancer.
Estrogen Receptor (ER) Rabbit Monoclonal
F4/80 Rabbit Monoclonal
Catalog No.
Size
Format
M3010
0.1ml
Concentrate
M3012
0.5ml
Concentrate
M3014
1.0ml
Concentrate
M3011
7.0ml
Ready-to-Use
Clone: SP1
Catalog No.
Size
Format
Immunogen: Synthetic peptide derived from C-terminus of human estrogen receptor alpha.
M4150
0.1ml
Concentrate
M4152
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of mouse F4/80 protein.
M4154
1.0ml
Concentrate
Application: IHC-P, WB
Application: IHC-P
M4151
7.0ml
Ready-to-Use
Species Reactivity: Human*
Clone: SP115
Species Reactivity: Mouse* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Mouse Liver
Control Tissue: Breast Carcinoma
Cellular Localization: Membrane
Cellular Localization: Nucleus Control Lysate: MCF7 Molecular Weight: 67 kDa Human Breast Carcinoma stained with anti-Estrogen Receptor (ER) antibody M301
Product Description: This antibody recognizes a protein of 67kDa, which is identified as estrogen receptor (ER). This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland.
Mouse Liver stained with anti-F4/80 antibody M415
Product Description: F4/80 is a cell surface glycoprotein and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages and a subpopulation of dendritic cells. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ regulatory T cells.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
49
F4/80 Rabbit Polyclonal
FcRH5 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E19250
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of mouse F4/80 protein.
E19252
0.5ml
Concentrate
Immunogen: Synthetic peptide near the C-terminus of human FcRH5 protein.
1.0ml
Concentrate
Application: IHC-P
E19254
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E19251
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18970
0.1ml
Concentrate
E18972
0.5ml
E18974 E18971
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung
Control Tissue: Tonsil
Cellular Localization: Membrane
Cellular Localization: Membrane
Human Lung stained with anti-F4/80 antibody E1897
Human Tonsil stained with anti-FcRH5 antibody E1925
Product Description: F4/80 antigen is a 160kDa cell surface glycoprotein expressed in mature tissue macrophages such as Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, and bone marrow stroma. F4/80 is also expressed in a subpopulation of dendritic cells but absent from macrophages located in T cell areas of the spleen and lymph node. Recent studies suggest a role for F4/80 in the generation of CD8+ regulatory T cells.
Product Description: Fc receptor homologs (FcRH5), also known as IRTA2 proteins, are transmembrane proteins with sequence homology to classical Fc receptor families. FcRH5 function as activating or inhibitory receptors on discrete B cell populations and are involved in B cell development and differentiation in peripheral lymphoid organs. FcRH5 expression is deregulated in multiple myeloma and Burkitt lymphoma cell lines with 1q21 abnormalities.
FAS Ligand Rabbit Polyclonal
FGFR-1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E10580
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from near N-terminus of human FAS ligand.
E10582
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human FGFR-1 protein.
1.0ml
Concentrate
Application: IHC-P
E10584
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E10581
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2710
0.1ml
Concentrate
E2712
0.5ml
E2714 E2711
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate, Testis, Tonsil
Control Tissue: Breast Carcinoma, Pituitary
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm, Membrane
Human Tonsil stained with anti-FAS Ligand antibody E271
Human Breast Carcinoma stained with anti-FGFR-1 antibody E1058
Product Description: Fas ligand is a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis. Various cells express Fas, where Fas ligand is expressed predominantly on activated T cells. Fas and Fas ligand are involved in the down-regulation of immune reactions as well as T cellmediated cytotoxicity.
Product Description: Fibroblast growth factors (FGFs) are members of a large family of structurally related polypeptides that regulates growth and differentiation in most cells. FGFR-1 is one of the four genes encoding for high affinity cell surface FGF receptors (FGFRs). FGFRs are members of the tyrosine kinase family of growth factor receptors. At the mRNA level, FGFR-1 is highly expressed in developing human tissues such as brain, vascular basement membrane, and skin.
FAS-Associated Phosphatase (FAP-1) Rabbit Polyclonal
FGFR-2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E10570
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 22902491 of human FAP-1.
E10572
0.5ml
Concentrate
Immunogen: Synthetic peptide from aa 362-374 of human FGFR-2 protein.
1.0ml
Concentrate
Application: IHC-P
E10574
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E10571
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12360
0.1ml
Concentrate
E12362
0.5ml
E12364 E12361
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma, Placenta
Control Tissue: Breast Carcinoma, Liver Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Human Colon Carcinoma stained with anti-FAS-Associated Phosphatase (FAP-1) antibody E1236
Human Breast Carcinoma stained with anti-FGFR-2 antibody E1057
Product Description: FAS-associated phosphatase (FAP-1), a novel protein tyrosine phosphatase, regulates FAS-induced apoptosis and nerve growth factor receptor (NGFR)-mediated pro-apoptotic signaling. It has been shown to associate with the fifteen amino acids at the carboxy terminus of FAS. FAP-1 contains three isoforms and a membrane-binding domain. It is present in most tissues with the exception of the liver and skeletal muscle, and is most abundant in lung, kidney and fetal brain.
50
Clone: N/A
Product Description: Fibroblast growth factors (FGFs) are members of a large family of structurally related polypeptides that regulates growth and differentiation in most cells. FGFR-2 is one of the four genes encoding for high affinity cell surface FGF receptors (FGFRs). FGFRs are members of the tyrosine kinase family of growth factor receptors. FGFR-2 is highly expressed in developing human tissues such as brain, choroids plexus, and lung.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies FGFR-3 Rabbit Polyclonal
FLK-1/KDR/VEGFR-2 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E3710
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human FGFR-3 protein.
E3712
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human FLK-1.
1.0ml
Concentrate
Application: IHC-P
E3714
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3711
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10230
0.1ml
Concentrate
E10232
0.5ml
E10234 E10231
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast, Breast Carcinoma
Control Tissue: Angiosarcoma, Placenta
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Human Breast stained with anti-FGFR-3 antibody E1023
Human Placenta stained with anti-FLK-1/KDR/VEGFR-2 antibody E371
Product Description: Fibroblast growth factors (FGFs) are members of a large family of structurally related polypeptides that regulates growth and differentiation in most cells. FGFR-3 is one of the four genes encoding for high affinity cell surface FGF receptors (FGFRs). FGFRs are members of the tyrosine kinase family of growth factor receptors. FGFR-3 is widely expressed in many fetal and adult human and animal tissues.
Product Description: FLK-1/KDR/VEGFR2, a cell membrane receptor kinase, is a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis. It contains seven immunoglobulin-like sequences in the extracellular domain and exhibits sequence similarity to FLT-1 and FLT-4.
FLI-1 Rabbit Polyclonal
FLT-1/VEGFR1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2800
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human FLI-1.
E2802
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human FLT-1.
1.0ml
Concentrate
Application: IHC-P
E2804
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2801
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4280
0.1ml
Concentrate
E4282
0.5ml
E4284 E4281
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Angiosarcoma, Ewing Sarcoma
Control Tissue: Angiosarcoma, Placenta
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm, Membrane
Human Ewing Sarcoma stained with anti-FLI-1 antibody E428
Human Placenta stained with anti-FLT-1/VEGFR1 antibody E280
Product Description: Fli-1 is a member of the ETS-1gene family which includes ETS-1, ETS-2, ERG-1, ERG-2, ELK, E74, FLI-1, PU-1 and PEA-3. Fli-1 is a nuclear protein and its defects are the cause of Ewing sarcoma (ES), a highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue in children and adolescents.
Product Description: FLT-1/vascular endothelial growth factor receptor 1 (VEGFR1), a cell membrane receptor kinase, is a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis. It contains seven immunoglobulin like sequences in the extracellular domain and exhibits sequence similarity to FLK-1 and FLT-4.
FLK-1 (mouse) Rabbit Monoclonal
FLT-4/VEGFR3 Rabbit Polyclonal
Clone: SP123
Catalog No.
Size
Format
E3870
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide near the N-terminus of mouse FLK-1 protein.
E3872
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human FLT-4 protein.
1.0ml
Concentrate
Application: IHC-P
E3874
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3871
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4230
0.1ml
Concentrate
M4232
0.5ml
M4234 M4231
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta
Control Tissue: Breast Carcinoma, Placenta
Cellular Localization: Membrane
Cellular Localization: Cytoplasm, Membrane
Human Placenta stained with anti-FLK-1 (mouse) antibody M423
Human Placenta stained with anti-FLT-4/VEGFR3 antibody E387
Product Description: FLK-1/KDR/VEGFR2, a cell membrane receptor kinase, is a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis. It contains seven immunoglobulin-like sequences in the extracellular domain and exhibits sequence similarity to FLT-1 and FLT-4.
Product Description: Three cell membrane receptor tyrosine kinases, FLT (also designated VEGF-R1), FLK-1 (also designated VEGF-R2) and FLT-4 (also designated VEGF-R3), are putatively involved in the growth of endothelial cells as characterized by the presence of seven immuno-globulin-like sequences in their extracellular domain. On the basis of structural similarity to FLT and FLK-1, it has been speculated that FLT-4 might represent a third receptor for either VEGF or a VEGF-related ligand.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
51
Fn14 Rabbit Polyclonal
FOXO1A Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Internal region of human Fn14.
E17820
0.1ml
Concentrate
Concentrate
Application: IHC-P
E17822
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human FOXO1A.
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
Ready-to-Use
Species Reactivity: Human*
E17824
7.0ml
E17821
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19080
0.1ml
E19082
0.5ml
E19084 E19081
Isotype: Rabbit IgG
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Control Tissue: Kidney, Placenta Cellular Localization: Membrane
Control Tissue: Prostate Carcinoma
Human Placenta stained with anti-Fn14 antibody E1908
Human Prostate Carcinoma stained with anti-FOXO1A antibody E1782
Cellular Localization: Cytoplasm, Nucleus
Product Description: Fibroblast growth factor-inducible 14 (Fn14) is the receptor for Tweak, a member of the TNF receptor family. It was first described as a weak inducer of apoptosis in some cell types. It is thought to promote angiogenesis and the proliferation of endothelial cells as well as modulating cellular adhesion to matrix proteins. Fn14 is highly expressed in glioma and some cancer cases of breast, pancreas, and liver.
Product Description: FOXO1A (FKHR or ForkHead in Rhabdomyosarcoma) is a member of a subfamily of the forkhead homeotic gene family of transcription factors. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C-terminus of the FOXO1A protein. Chromosomal aberrations involving FOXO1A are associated with rhabdomyosarcoma 2 (RMS2) or alveolar rhabdomyosarcoma.
FOXA1 Rabbit Monoclonal
FOXO3A Rabbit Polyclonal Clone: SP88
Catalog No.
Size
Format
E17730
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from near C-terminus of human FOXA1 protein.
E17732
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human FOXO3A protein.
1.0ml
Concentrate
Application: IHC-P
E17734
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E17731
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3880
0.1ml
Concentrate
M3882
0.5ml
M3884 M3881
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate
Control Tissue: Breast Carcinoma, Tonsil
Cellular Localization: Nucleus in Breast Carcinoma, Prostate. Cytoplasm in most malignancies.
Cellular Localization: Cytoplasm, Nucleus
Human Prostate stained with anti-FOXA1 antibody M388
Human Breast Carcinoma stained with anti-FOXO3A antibody E1773
Product Description: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
Product Description: FOXO3A belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
FOXA1 Rabbit Polyclonal
FOXP1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E19060
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from near C-terminus of human FOXA1 protein.
E19062
0.5ml
Concentrate
Immunogen: Synthetic peptide near C-terminus of human FOXP1.
1.0ml
Concentrate
Application: IHC-P
E19064
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E19061
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18850
0.1ml
Concentrate
E18852
0.5ml
E18854 E18851
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Nucleus
Human Breast Carcinoma stained with anti-FOXA1 antibody E1885
Human Tonsil stained with anti-FOXP1 antibody E1906
Product Description: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
52
Clone: N/A
Product Description: Forkhead box (FOX) proteins are a group of 43 conserved transcription factors that are further divided into subgroups. The FOXP subgroup has four members, FOXP1 to FOXP4, which are widely expressed and contribute some critical roles in organ development, immune response, and cancer pathogenesis. FOXP1 is a transcriptional repressor that plays an important role in lung, cardiac valve, and B cell development.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies FOXP3 Rabbit Monoclonal
FPGS Rabbit Polyclonal Clone: SP97
Catalog No.
Size
Format
E18340
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human FOXP3 protein.
E18342
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human FPGS.
1.0ml
Concentrate
Application: IHC-P
E18344
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18341
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3970
0.1ml
Concentrate
M3972
0.5ml
M3974 M3971
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Breast Carcinoma, Liver Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm
Human Tonsil stained with anti-FOXP3 antibody M397
Human Breast Carcinoma stained with anti-FPGS antibody E1834
Product Description: Forkhead box protein P3 (FOXP3) is a member of the forkhead/ winged-helix family of transcriptional regulators. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25+ and CD4+ T cells, at low level in CD4+/CD25- cells, and is absent in CD4-/CD8+ T cells. FOXP-3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.
Product Description: Folylpoly-gamma-glutamate synthetase (FPGS) converts folates to polyglutamate derivatives by catalyzing the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs. FFPGS is widely expressed in human tumors and is tightly linked either to proliferation or to a lack of differentiation.
FOXP3 Rabbit Polyclonal
FRA-2 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E4210
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human FOXP3 protein.
E4212
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human FRA-2 protein.
1.0ml
Concentrate
Application: IHC-P
E4214
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4211
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18490
0.1ml
Concentrate
E18492
0.5ml
E18494 E18491
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Prostate Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Tonsil stained with anti-FOXP3 antibody E1849
Human Prostate Carcinoma stained with anti-FRA-2 antibody E421
Product Description: Forkhead box protein P3 (FOXP3) is a member of the forkhead/ winged-helix family of transcriptional regulators. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25+ and CD4+ T cells, at low level in CD4+/CD25- cells, and is absent in CD4-/CD8+ T cells. FOXP-3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.
Product Description: FRA-2 has homologous sequence with c-FOS, FRA-1, and FOS B. It forms heterodimers with c-Jun that recognize specific DNA sequences, such as the binding site for transcription factor AP-1.
FOXP4 Rabbit Polyclonal
Fragile Histidine Triad (FHIT) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E3640
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human FOXP4 protein.
E3642
0.5ml
Concentrate
Immunogen: Recombinant full length human FHIT protein.
1.0ml
Concentrate
Application: IHC-P
E3644
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3641
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16390
0.1ml
Concentrate
E16392
0.5ml
E16394 E16391
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung
Control Tissue: Breast
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm
Human Lung stained with anti-FOXP4 antibody E1639
Human Breast stained with anti-Fragile Histidine Triad (FHIT) antibody E364
Product Description: FOXP4 gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx.
Product Description: This antibody reacts with human FHIT (Fragile Histidine Triad). Alterations and deletions of the FHIT gene are strongly linked to the genesis and establishment of human tumors of the lung, cervix, breast, colon, stomach, and pancreas. In normal cells, FHIT may act as a tumor suppressor.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
53
GADD153 Rabbit Polyclonal
Gastrin-1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E4490
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant human full length GADD153 protein.
E4492
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of gastrin-1.
1.0ml
Concentrate
Application: IHC-P
E4494
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4491
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10980
0.1ml
Concentrate
E10982
0.5ml
E10984 E10981
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Stomach
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Breast Carcinoma stained with anti-GADD153 antibody E1098
Human Stomach stained with anti-Gastrin-1 antibody E449
Product Description: GADD153 has been described as a growth arrest and DNA damage-inducible gene that encodes a C/EBP-related nuclear protein. GADD153 expression is induced by a variety of cellular stresses. GADD153 functions to block cells in G1 to S phase in cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD153 dimers away from classical C/EBP binding sites.
Product Description: Gastrin is a 17 amino acid peptide hormone and neurotransmitter widely distributed throughout the gastrointestinal (GI) tract and the central nervous system (CNS). Antibodies that react specifically with gastrin may be used to study the differential tissue expression and intracellular and subcellular localization of gastrin in neuroendocrine cells of the gastrointestinal tract, and in the CNS.
Gamma Glutamylcysteine Synthetase (GCS) Rabbit Polyclonal
GDNF Rabbit Polyclonal
Catalog No.
Size
Format
E16740
0.1ml
Concentrate
E16742
0.5ml
Concentrate
E16744
1.0ml
Concentrate
E16741
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to internal region of rat heavy subunit of GCS protein.
E11020
0.1ml
Concentrate
E11022
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to aa 186-205 of human GDNF.
E11024
1.0ml
Concentrate
Application: IHC-P, WB
Application: IHC-P
E11021
7.0ml
Ready-to-Use
Species Reactivity: Human*
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain (Hippocampus)
Control Tissue: Kidney, Testis
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm Control Lysate: Human Kidney Molecular Weight: 73 kDa Human Testis stained with anti-Gamma Glutamylcysteine Synthetase (GCS) antibody E1674
Human Brain stained with anti-GDNF antibody E1102
Product Description: Gamma Glutamylcysteune Synthetase (GCS) is the first enzyme and rate limiting step in the glutathione biosynthesis pathway. Glutathione (GSH) plays an important role in detoxification of oxidants and toxins from the cells. It is composed of heavy and light subunits. These subunits are coded by different genes which are controlled by different mechanisms. The heavy subunit carries the catalytic activity and can be inhibited through feedback mechanism by GSH.
Product Description: Glial cell line-derived neurotrophic factor (GDNF) has been identified as a potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons. GDNF promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. It was suggested that GDNF may have utility in the treatment of Parkinson’s disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.
GANP Rabbit Polyclonal
Glial Fibrillary Acidic Protein (GFAP) Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3780
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 1-150 of human GANP.
M3782
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human GFAP protein.
1.0ml
Concentrate
Application: IHC-P
M3784
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3781
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E14080
0.1ml
Concentrate
E14082
0.5ml
E14084 E14081
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Astrocytoma
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm
Human Tonsil stained with anti-GANP antibody E1408
Human Astrocytoma stained with anti-Glial Fibrillary Acidic Protein (GFAP) antibody M378
Product Description: Germinal center-associated nuclear protein (GANP) is thought to be involved in the nuclear localization pathway of MCM3 and in regulation of cell proliferation of antigen-driven B cells in germinal centers. It carries an MCM-binding domain in the carboxyl-terminal side and it is up-regulated selectively in germinal centers.
54
Clone: SP78
Product Description: Glial Fibrillary Acidic Protein (GFAP) is specific to astrocytes (i.e., glial cells) and ependymal cells of the central nervous system. The antibody to GFAP is useful for documenting astrocytic differentiation in tumors outside the CNS.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Glial Fibrillary Acidic Protein (GFAP) Rabbit Polyclonal
GluR1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3060
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human GFAP.
E3062
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human GluR1.
1.0ml
Concentrate
Application: IHC-P
E3064
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3061
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18320
0.1ml
Concentrate
E18322
0.5ml
E18324 E18321
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Astrocytoma
Control Tissue: Brain
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Astrocytoma stained with anti-Glial Fibrillary Acidic Protein (GFAP) antibody E1832
Human Brain stained with anti-GluR1 antibody E306
Product Description: Glial Fibrillary Acidic Protein (GFAP) is specific to astrocytes (i.e., glial cells) and ependymal cells of the central nervous system. The antibody to GFAP is useful for documenting astrocytic differentiation in tumors outside the CNS.
Product Description: Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-3, KAI-2), which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors and they activate phopholipases or adenylylcyclase once they are activated.
Glial Fibrillary Acidic Protein (GFAP) Mouse Monoclonal
GluR2/3 Rabbit Polyclonal
Clone: SPM507
Catalog No.
Size
Format
Concentrate
Immunogen: Porcupine spinal cord.
E3000
0.1ml
Concentrate
Concentrate
Application: IHC-P
E3002
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human GluR2/3.
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
Ready-to-Use
Species Reactivity: Human*
E3004
7.0ml
E3001
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16510
0.1ml
E16512
0.5ml
E16514 E16511
Isotype: Mouse IgG1
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Control Tissue: Astrocytoma, Brain Cellular Localization: Cytoplasm
Control Tissue: Cerebellum
Human Astrocytoma stained with anti-Glial Fibrillary Acidic Protein (GFAP) antibody E1651
Human Cerebellum stained with anti-GluR2/3 antibody E300
Cellular Localization: Cytoplasm
Product Description: Glial Fibrillary Acidic Protein (GFAP) is specific to astrocytes (i.e., glial cells) and ependymal cells of the central nervous system. The antibody to GFAP is useful for documenting astrocytic differentiation in tumors outside the CNS.
Product Description: Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-3, KAI-2), which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G protein coupled receptors and they activate phopholipases or adenylylcyclase once they are activated.
Glucagon Rabbit Polyclonal
GluR6/7 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2930
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human glucagon.
E2932
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human GluR6/7.
1.0ml
Concentrate
Application: IHC-P
E2934
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2931
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18180
0.1ml
Concentrate
E18182
0.5ml
E18184 E18181
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Pancreas
Control Tissue: Brain
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Pancreas stained with anti-Glucagon antibody E1818
Human Brain stained with anti-GluR6/7 antibody E293
Product Description: Glucagon is a hormone that is secreted by alpha cells in the pancreas. Glucagon antagonizes insulin by converting glycogen to glucose in the liver and increasing blood sugar levels. Glucagon-like peptide 1 (GLP1), Glucagon-like peptide 2 (GLP2), VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase activating polypeptide) are in the glucagons hormone family.
Product Description: Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-3, KAI-2), which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors and they activate phopholipases or adenylylcyclase once they are activated.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
55
GLUT-1 Rabbit Polyclonal
Glutamic Acid Decarboxylase 65 (GAD65) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E3310
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human GLUT-1 protein.
E3312
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human GAD65.
1.0ml
Concentrate
Application: IHC-P
E3314
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3311
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2840
0.1ml
Concentrate
E2842
0.5ml
E2844 E2841
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Esophagus
Control Tissue: Pancreas
Cellular Localization: Membrane
Cellular Localization: Cytoplasm
Human Esophagus stained with anti-GLUT-1 antibody E284
Human Pancreas stained with anti-Glutamic Acid Decarboxylase 65 (GAD65) antibody E331
Product Description: Glucose is fundamental to the metabolism of mammalian cells. Several glucose transporter protein (Glut) isoforms have been identified and shown to function in response to insulin and IGF-1 induced signaling. GLUT-1 is detectable in many human tissues including those of the colon, lung, stomach, esophagus, and breast.
Product Description: Glutamate decarboxylase 2 (GAD65) catalyzes the production of Îł-Aminobutyric acid (GABA). Adults express two forms of glutamate decarboxylase (GAD), GAD65 and GAD67. Both are expressed in most GABA containing neurons. GAD65 appears to be targeted to the membrane and nerve endings; GAD65 is predominantly expressed in pancreatic beta cells. Autoantibodies to GAD65 are strongly associated with insulin-dependent diabetes mellitus.
GLUT-1 Mouse Monoclonal
Glutamic Acid Decarboxylase 67 (GAD67) Rabbit Polyclonal Clone: SPM498
Catalog No.
Size
Format
E10260
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human GLUT-1 protein.
E10262
0.5ml
Concentrate
Immunogen: Synthetic peptide from near N-terminus of mouse GAD67 protein.
1.0ml
Concentrate
Application: IHC-P
E10264
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E10261
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E13810
0.1ml
Concentrate
E13812
0.5ml
E13814 E13811
Clone: N/A
Species Reactivity: Human*
Isotype: Mouse IgG2a/k
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Esophagus
Control Tissue: Brain, Pancreas
Cellular Localization: Membrane
Cellular Localization: Cytoplasm, Membrane
Human Esophagus stained with anti-GLUT-1 antibody E1381
Human Pancreas stained with anti-Glutamic Acid Decarboxylase 67 (GAD67) antibody E1026
Product Description: Glucose is fundamental to the metabolism of mammalian cells. Several glucose transporter protein (Glut) isoforms have been identified and shown to function in response to insulin and IGF-1 induced signaling. GLUT-1 is detectable in many human tissues including those of the colon, lung, stomach, esophagus, and breast.
Product Description: Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of L-glutamate to gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, and a putative paracrine signal molecule in pancreatic islets. GAD67 is a cytoplasmic protein and is encoded on chromosome 2.
GLUT-3 Rabbit Polyclonal
Glypican-3 Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3860
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human GLUT-3 protein.
M3862
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
M3864
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3861
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3270
0.1ml
Concentrate
E3272
0.5ml
E3274 E3271
Isotype: Rabbit IgG Control Tissue: Placenta Cellular Localization: Cytoplasm
Clone: SP86 Immunogen: Synthetic peptide derived from C-terminus of human glypican-3 protein. Application: IHC-P, WB Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Placenta Cellular Localization: Membrane Control Lysate: HepG2 Molecular Weight: 64 kDa
Human Placenta stained with anti-GLUT-3 antibody E327
Human Placenta stained with anti-Glypican-3 antibody M386
Product Description: Glucose is fundamental to the metabolism of mammalian cells. Several glucose transporter protein (GLUT) isoforms have been identified and shown to function in response to insulin and IGF-1 induced signaling. GLUT-3 is detectable in a few normal cell type spermatids in testis with active spermatogenesis, placental trophoblast membranes, and neurons in brain. GLUT-3 staining is also detectable in human cancers including those of the ovary, lung, and testis.
Product Description: Expression alteration of glypican-3 (GPC3) is associated with several malignancies and has been identified as an overexpressed gene in hepatocellular carcinoma (HCC). Glypican-3 is a cell surface proteoglycan that bears heparan sulfate (HS). It may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs.
56
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Glypican-3 Rabbit Polyclonal
Granzyme B Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2580
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human glypican-3 protein.
E2582
0.5ml
Concentrate
Immunogen: Synthetic peptide from N-terminus of human granzyme B.
1.0ml
Concentrate
Application: IHC-P
E2584
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2581
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18870
0.1ml
Concentrate
E18872
0.5ml
E18874 E18871
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Liver Carcinoma
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm
Human Liver Carcinoma stained with anti-Glypican-3 antibody E1887
Human Tonsil stained with anti-Granzyme B antibody E258
Product Description: Expression alteration of glypican-3 (GPC3) is associated with several malignancies and has been identified as an overexpressed gene in hepatocellular carcinoma (HCC). Glypican-3 is a cell surface proteoglycan that bears heparan sulfate (HS). It may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs.
Product Description: Granzyme A and granzyme B are serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. Both granzyme A and granzyme B are synthesized as inactive proenzymes, and are stored within cytolytic granules and released by effector cells during degradation. This antibody should be useful for the localization of granzyme B-containing lytic granules and for the characterization of activated CTLs or NK cells.
GNB2 Rabbit Polyclonal
GRB2-Associated Binder 1 (GAB-1) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E3620
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from near N-terminus of human GNB2 protein.
E3622
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human GAB-1.
1.0ml
Concentrate
Application: IHC-P
E3624
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3621
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17940
0.1ml
Concentrate
E17942
0.5ml
E17944 E17941
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta
Control Tissue: Astrocytoma
Cellular Localization: Membrane
Cellular Localization: Cytoplasm
Human Placenta stained with anti-GNB2 antibody E1794
Human Astrocytoma stained with anti-GRB2-Associated Binder 1 (GAB-1) antibody E362
Product Description: Guanine nucleotide-binding protein subunit beta-2 (GNB2) is one of the three subunits (alpha, beta and gamma) for guanine nucleotide binding proteins (G proteins). G proteins are membrane associated and heterotrimeric proteins. G proteins and their receptors (GPCRs) form one of the most prevalent signaling systems in mammalian cells. G protein signaling system regulates sensory perception, cell growth, and hormonal regulation.
Product Description: GAB-1 is a multisubstrate docking protein downstream in the signaling pathways of different receptor tyrosine kinases, including the epidermal growth factor receptor (EGFR) and appears to play a crucial role in cellular growth response, transformation, and apoptosis. Experimental data indicates that GAB1 coupling to the Met receptor requires binding of GRB2 and correlates with the transforming potential of Tpr-Met.
GP200 (Renal Cell Carcinoma Marker) Mouse Monoclonal
GRP75 Rabbit Polyclonal
Clone: SPM487
Catalog No.
Size
Format
Concentrate
Immunogen: Recombinant human gp200 protein.
E12490
0.1ml
Concentrate
Concentrate
Application: IHC-P
E12492
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to aa 661-679 of human GRP75 protein.
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
Ready-to-Use
Species Reactivity: Human*
E12494
7.0ml
E12491
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E11050
0.1ml
E11052
0.5ml
E11054 E11051
Isotype: Mouse IgG1/k
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Control Tissue: Kidney, Renal Cell Carcinoma Cellular Localization: Cytoplasm, Membrane
Control Tissue: Colon Carcinoma
Human Renal Cell Carcinoma stained with anti-GP200 (Renal Cell Carcinoma Marker) antibody E1105
Human Colon Carcinoma stained with anti-GRP75 antibody E1249
Product Description: GP200 is localized along the brush border of renal tubule and Bowman’s capsule, the luminal surfaces of breast lobules and ducts and the epididymal tubular epithelium, cytoplasm of parathyroid parenchymal cells and the colloid of thyroid follicles. GP200 is reportedly expressed by 93% of primary and 84% of metastatic renal cell carcinomas.
Cellular Localization: Cytoplasm
Product Description: The HSP70 family is composed of four highly conserved proteins: HSP70, HSC70, GRP75 and GRP78. These proteins serve a variety of roles. GRP75 expression is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin. GRP75 and GRP78 are unresponsive to heat stress and are induced by glucose deprivation.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
57
GRP78 Rabbit Polyclonal
GSK-3 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2910
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to near N-terminus of human GRP78 protein.
E2912
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human GSK-3.
1.0ml
Concentrate
Application: IHC-P
E2914
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2911
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12570
0.1ml
Concentrate
E12572
0.5ml
E12574 E12571
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Brain
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Breast Carcinoma stained with anti-GRP78 antibody E1257
Human Brain stained with anti-GSK-3 antibody E291
Product Description: The HSP70 family is composed of four highly conserved proteins: HSP70, HSC70, GRP75 and GRP78. GRP78 is localized in the endoplasmic reticulum where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains.
Product Description: Glycogen Synthase Kinase-3 (GSK-3) differs from most serine/ threonine kinases in that it is active in the absence of the action of signaling pathways. Two isoforms exist, GSK-3α and GSK-3β. The function of GSK-3 is to phosphorylate glycogen synthase and thereby inactivate it. Insulin action stimulates the PI 3-kinase pathway, resulting in Akt activation, which phosphorylates and inactivates GSK-3.
GRP94 Rabbit Polyclonal
Guanylyl Cyclase beta Rabbit Polyclonal
Catalog No.
Size
Format
E13860
0.1ml
Concentrate
E13862
0.5ml
Concentrate
E13864
1.0ml
Concentrate
E13861
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to C-terminus of human GRP94 protein.
E10270
0.1ml
Concentrate
E10272
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human guanylyl cyclase beta 1, soluble.
E10274
1.0ml
Concentrate
Application: IHC-P, WB
Application: IHC-P
E10271
7.0ml
Ready-to-Use
Species Reactivity: Human*
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm Control Lysate: HeLa Molecular Weight: 94 kDa
Human Brain stained with anti-Guanylyl Cyclase beta antibody E1027
Human Breast Carcinoma stained with anti-GRP94 antibody E1386
Product Description: Glucose-regulated protein 94kDa (GRP-94), also known as endoplasmin, is a member of human heat shock protein (HSP) 90 family. GRP-94 is a cytosolic protein that participates in signaling pathways with PKC ε to protect cells from external damage, particularly in heat shock-mediated events. GRP-94 localizes to the ER and is highly expressed in BGC-823 human gastric carcinoma cells and is upregulated in human endothelial cells in response to hypoxia by HIF-1.
Product Description: Soluble guanylyl cyclase catalyses in a Mg2+ or Mn2+ dependent manner, the conversion of guanosine-5’-triphosphate (GTP) to cyclic guanosine-3’,5monophosphate (cGMP) and pyrophosphate. This enzyme is a major physiological receptor for nitric oxide (NO), an important intra- and intercellular membrane-permeant signaling molecule.
GRSF-1 Rabbit Polyclonal
H. Pylori Rabbit Polyclonal Clone: N/A
Clone: N/A
Catalog No.
Size
Format
0.1ml
Concentrate
Immunogen: Purified Helicobacter pylori.
Concentrate
Immunogen: Synthetic peptide derived from internal region of human GRSF-1 protein.
E3010 E3012
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E3014
1.0ml
Concentrate
Ready-to-Use
E3011
7.0ml
Ready-to-Use
Species Reactivity: Human*
7.0ml
Catalog No.
Size
Format
E18690
0.1ml
Concentrate
E18692
0.5ml
E18694 E18691
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: H. Pylori Infected Tissue
Control Tissue: Brain
Cellular Localization: H. Pyloric
Cellular Localization: Cytoplasm
Human Brain stained with anti-GRSF-1 antibody E1869
Product Description: G-rich sequence factor 1 (GRSF-1) is a cytoplasmic protein that binds RNAs containing the G-rich element. GRSF-1 is up-regulated with prostate cancer progression and down regulated by the differentiating agents phenylacetate and phenylbutyrate. The function of GRSF-1 is uncharacterized, but potential roles include mRNA transport, stabilization, and translation. It might be involved in prostate cancer metastasis.
58
Human H. Pylori infected Stomach stained with anti-H. Pylori antibody E301
Product Description: Helicobacter pylori (H. Pylori) is known to cause peptic ulcers and chronic gastritis in human. It is associated with duodenal ulcers and may be involved in development of adenocarcimona and low grade lymphoma of mucosa-associated lymphoid tissue in the stomach.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies H. Pylori Mouse Monoclonal
Heat Shock Protein 60 (HSP60) Rabbit Polyclonal Clone: SPM526
Catalog No.
Size
Format
Concentrate
Immunogen: Purified helicobacter pylori.
E12450
0.1ml
Concentrate
Concentrate
Application: IHC-P
E12452
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to aa 31-50 of human HSP60 protein.
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P, WB
Ready-to-Use
Species Reactivity: Human*
E12454
7.0ml
E12451
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18380
0.1ml
E18382
0.5ml
E18384 E18381
Isotype: Mouse IgG1/k
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Control Tissue: H. Pylori Infected Tissue
Control Tissue: Colon Carcinoma
Cellular Localization: H. Pyloric
Cellular Localization: Cytoplasm Control Lysate: HeLa Molecular Weight: 60 kDa
Human H. Pylori infected Stomach stained with anti-H. Pylori antibody E1838
Human Colon Carcinoma stained with anti-Heat Shock Protein 60 (HSP60) antibody E1245
Product Description: Helicobacter pylori (H. Pylori) is known to cause peptic ulcers and chronic gastritis in human. It is associated with duodenal ulcers and may be involved in development of adenocarcimona and low grade lymphoma of mucosa-associated lymphoid tissue in the stomach.
Product Description: A wide variety of environmental and pathophysiological stressful condition triggers the synthesis of heat shock proteins or stress response proteins. HSP60 is a potential antigen in a number of autoimmune diseases including human arthritis.
HDAC1 Rabbit Polyclonal
Heat Shock Protein 70 (HSP70) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E12330
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human HDAC1 protein.
E12332
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E12334
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E12331
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3550
0.1ml
Concentrate
E3552
0.5ml
E3554 E3551
Clone: N/A Immunogen: Synthetic peptide corresponding to aa 574-591 of human HSP70 protein. Application: IHC-P, WB Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Tonsil
Control Tissue: Breast Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm, Nucleus Control Lysate: 293T Molecular Weight: 70 kDa
Human Breast Carcinoma stained with anti-HDAC1 antibody E355
Human Breast Carcinoma stained with anti-Heat Shock Protein 70 (HSP70) antibody E1233
Product Description: Mammalian HADC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases. The deacetylation of histones is associated with transcriptional silencing.
Product Description: The HSP70 family is composed of four highly conserved proteins: HSP70, HSC70, GRP75 and GRP78. These proteins serve a variety of roles: they act as molecular chaperones facilitating the assembly of multi-protein complexes, they participate in the translocation of polypeptides across cell membranes and to the nucleus and they aid in the proper folding of nascent polypeptide chain. HSP70 expression is strongly induced in response to heat stress.
HDAC2 Rabbit Polyclonal
hENT1** Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M4200
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human HDAC2.
M4202
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human hENT1 protein.
1.0ml
Concentrate
Application: IHC-P, WB
M4204
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M4201
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10640
0.1ml
Concentrate
E10642
0.5ml
E10644 E10641
Clone: SP120
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Pancreas, Tonsil
Cellular Localization: Nucleus
Cellular Localization: Membrane
Control Lysate: K562 Molecular Weight: 60 kDa Human Tonsil stained with anti-HDAC2 antibody E1064
Product Description: Histone acetylation is a dynamic process whose levels are determined by the net activities of histone acetyltransferases (HATs) and the competing enzymes histone deacetylases (HDACs). Both activities are associated with the nuclear matrix. Six or seven different mammalian HDACs have been described. HDAC1, HDAC2 and several other HDACs are the catalytic subunits of different multiprotein regulatory complexes.
Human Pancreas stained with anti-hENT1 antibody M420
Product Description: Human equilibrative nucleoside transporter 1 (hENT1) is a member of the equilibrative nucleoside transporter family. It is a transmembrane glycoprotein in the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides. Nucleoside transporters such as hENT1 are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways. These transporters are necessary for the uptake of cytotoxic nucleosides used for chemotherapies.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
59
HMGA2 Rabbit Polyclonal
ID3 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E14050
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human HMGA2.
E14052
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human ID3 protein.
1.0ml
Concentrate
Application: IHC-P
E14054
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E14051
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16330
0.1ml
Concentrate
E16332
0.5ml
E16334 E16331
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Breast Carcinoma stained with anti-HMGA2 antibody E1633
Human Breast Carcinoma stained with anti-ID3 antibody E1405
Product Description: HMGA2, previously known as HMGI-C, belongs to the group of high mobility chromosomal proteins that have the AT-hook DNA-binding motif. It is highly and ubiquitously expressed during embryogenesis. Chromosomal rearrangements of the HMGA2 gene and overexpression are frequently associated with benign and malignant tumors, respectively. Human and mouse HMGA2 share 95% amino acid sequence identity.
Product Description: DNA-binding protein inhibitor ID-3 (ID3) is a basic helix-loophelix (bHLH) protein that inhibits muscle-specific gene expression by the binding of E2A-containing protein complexes to the muscle creatine kinase E-box enhancer. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation.
Human Growth Hormone (HGH) Rabbit Polyclonal
IKAROS Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Purified human growth hormone.
M4080
0.1ml
Concentrate
Concentrate
Application: IHC-P
M4082
0.5ml
Concentrate
Immunogen: Synthetic peptide near the N-terminus of human IKAROS.
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
Ready-to-Use
Species Reactivity: Human*
M4084
7.0ml
M4081
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17470
0.1ml
E17472
0.5ml
E17474 E17471
Isotype: Rabbit IgG
Clone: SP108
Species Reactivity: Human* Isotype: Rabbit IgG
Control Tissue: Anterior Pituitary Cellular Localization: Cytoplasm
Control Tissue: Tonsil
Human Anterior Pituitary stained with anti-Human Growth Hormone (HGH) antibody E1747
Human Tonsil stained with anti-IKAROS antibody M408
Cellular Localization: Nucleus
Product Description: HGH is produced by the somatotroph cells in the pituitary. HGH acts through binding to membrane receptors. Ligand binding induces receptor dimerization and activation of the receptor-associated kinase. This results in phosphorylation of the kinase itself, of the receptor, and of many cellular proteins including the Stat proteins as well as adaptors leading to the activation of the Ras/MAP kinase pathway and of the PI-3 kinase pathway.
Product Description: DNA-binding protein IKAROS functions in the specification and the maturation of the T lymphocyte. It also interacts with a critical control element in the terminal deoxynucleotidyl transferase promoter as well as with the promoters for other genes expressed during early stages of B cell and T cell development.
ID2 Rabbit Polyclonal
IKAROS Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E19000
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human ID2 protein.
E19002
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from near N-terminus of human IKAROS protein.
1.0ml
Concentrate
Application: IHC-P
E19004
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E19001
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16410
0.1ml
Concentrate
E16412
0.5ml
E16414 E16411
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Tonsil
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Breast Carcinoma stained with anti-ID2 antibody E1641
Human Tonsil stained with anti-IKAROS antibody E1900
Product Description: Inhibitor of differentiation 2 (ID2) protein is a transcriptional modulator. ID2 participates in the differentiation and cell cycle progression in organisms. It belongs to a protein family characterized by a helix-loop-helix (HLH) region, but lacking the basic amino acid domain required to bind to DNA. Id2 can disrupt the antiproliferative effects of retinoblastoma (Rb) family tumor suppressor proteins and facilitate the progression of the cell cycle.
60
Clone: N/A
Product Description: DNA-binding protein IKAROS functions in the specification and the maturation of the T lymphocyte. It also interacts with a critical control element in the terminal deoxynucleotidyl transferase promoter as well as with the promoters for other genes expressed during early stages of B cell and T cell development.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Inhibin-alpha Rabbit Polyclonal
IPO-38 (Proliferation Marker) Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E16580
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human inhibin-alpha.
E16582
0.5ml
Concentrate
Immunogen: Spleen cells of a patient with hairy cell leukemia.
1.0ml
Concentrate
Application: IHC-P, WB
E16584
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E16581
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17390
0.1ml
Concentrate
E17392
0.5ml
E17394 E17391
Clone: SPM515
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Mouse IgM/k
Control Tissue: Testis
Control Tissue: Tonsil
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus
Control Lysate: HeLa Molecular Weight: 40 kDa Human Testis stained with anti-Inhibin-alpha antibody E1739
Human Tonsil stained with anti-IPO-38 (Proliferation Marker) antibody E1658
Product Description: Inhibin is a dimeric glycoprotein hormone from the TGF-beta family made up of alpha and beta subunits. It inhibits the production of folliclestimulating hormone from the pituitary while activin stimulates the production of FSH. It is suggested that inhibin may act as a gonadal tumor suppressor.
Product Description: IPO-38 antigen is present in the nuclei of proliferating cells such as Hodgkin’s disease and non-Hodgkin’s lymphomas, different forms of leukemias, breast and colorectal carcinomas, and PHA-stimulated lymphocytes. It is not expressed in the cells of non-stimulated lymphocytes and granulocytes.
Integrin beta 5 Rabbit Polyclonal
IRS-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E12590
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human integrin beta 5 subunit.
E12592
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to aa 1223-1242 of human IRS-1.
1.0ml
Concentrate
Application: IHC-P
E12594
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E12591
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2860
0.1ml
Concentrate
E2862
0.5ml
E2864 E2861
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bone Marrow, Colon Carcinoma, Small Intestine
Control Tissue: Colon Carcinoma Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Human Small Intestine stained with anti-Integrin beta 5 antibody E286
Human Colon Carcinoma stained with anti-IRS-1 antibody E1259
Product Description: Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. Most integrin receptors bind ligands that are components of the extracellular matrix, including fibronectin, collagen and vitronectin. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors.
Product Description: The insulin receptor substrate-1 (IRS-1), a 170-185kDa protein major substrate of the insulin receptor is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor (IGF-I) and interleukin 4. IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues.
Involucrin Rabbit Polyclonal
JAB1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E10280
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 420-578 of human involucrin.
E10282
0.5ml
Concentrate
Immunogen: Synthetic peptide from N-terminus of human JAB1 protein.
1.0ml
Concentrate
Application: IHC-P
E10284
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E10281
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10630
0.1ml
Concentrate
E10632
0.5ml
E10634 E10631
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Skin
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Nucleus
Human Skin stained with anti-Involucrin antibody E1063
Human Breast Carcinoma stained with anti-JAB1 antibody E1028
Product Description: Involucrin is a cytoplasmic protein precursor of the epidermal cornified envelope that becomes cross-linked by transglutaminase during envelope assembly. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea which lacks a distinct cornified layer. The protein is a useful marker of terminal differentiation. It is tightly linked to the onset of differentiation and first expressed in the immediate suprabasal layers of the epidermis.
Product Description: Jun activation domain-binding protein-1 (JAB1) also designated COP9 subunits 5 (COPS5) or SGN5 is a coactivator of AP-1 transcription factor that also promotes degradation of the cyclin-dependent kinase inhibitor p27Kip1. JAB1 interacts with c-Jun AP-1 containing complexes, and enhances transactivation from AP-1dependent promoters. JAB1 is highly conserved in evolution and is widely expressed in mammalian tissues. It is localized both in the nucleus and the cytoplasm.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
61
J-chain Rabbit Monoclonal
Kappa Light Chain (B Cell Marker) Mouse Monoclonal Clone: SP105
Catalog No.
Size
Format
E16520
0.1ml
Concentrate
Immunogen: B-lymphoma cells.
Concentrate
Immunogen: Synthetic peptide near the internal region of human J-chain.
E16522
0.5ml
Concentrate
Concentrate
Application: IHC-P
Application: IHC-P, WB
1.0ml
E16524
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*, Mouse*
E16521
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
M4050
0.1ml
Concentrate
M4052
0.5ml
M4054 M4051
Isotype: Rabbit IgG
Clone: SPM508
Isotype: Mouse IgG1 Control Tissue: Tonsil
Control Tissue: Tonsil
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Control Lysate: Human Spleen Molecular Weight: 25 kDa
Human Tonsil stained with anti-J-chain antibody M405
Human Tonsil stained with anti-Kappa Light Chain (B Cell Marker) antibody E1652
Product Description: J chain is a small glycopeptide and is structurally unrelated to heavy or light chains, but is synthesized by all plasma cells. J chain is linked to IgA and IgM by disulfide bonds, however, it has been detected in IgG- and IgD-containing cells. B cells secrete J chain at an early stage of differentiation. J chains are present in a large proportion of the immunoglobulin-positive cells in the germinal centers of the tonsil and lymph node.
Product Description: Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the light chains are divided into constant and variable regions. The constant regions have the same amino acid sequences between all the immunoglobulin classes. The variable regions have approximately 110 amino acids with high sequence variability. Kappa light chain contains one immunoglobulin like domain.
J-chain Rabbit Polyclonal
Keratin 5 Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3270
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from near C-terminus of human J-chain protein.
M3272
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human cytokeratin 5.
1.0ml
Concentrate
Application: IHC-P
M3274
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3271
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19010
0.1ml
Concentrate
E19012
0.5ml
E19014 E19011
Clone: SP27
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Breast, Mesothelioma, Prostate, Skin
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm Control Lysate: A431 Molecular Weight: 58 kDa
Human Tonsil stained with anti-J-chain antibody E1901
Human Prostate Adenocarcinoma stained with anti-Keratin 5 antibody M327
Product Description: J chain is a small glycopeptide and is structurally unrelated to heavy or light chains, but is synthesized by all plasma cells. J chain is linked to IgA and IgM by disulfide bonds, however, it has been detected in IgG- and IgD-containing cells. B cells secrete J chain at an early stage of differentiation. J chains are present in a large proportion of the immunoglobulin-positive cells in the germinal centers of the tonsil and lymph node.
Product Description: Twenty human keratins are divided into acidic and basic subfamilies. Members of the acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Human keratins are useful markers in cancer research. Cytokeratin 5 is expressed in breast myoepithelia cells, prostate basal cells, most epithelial and biphasic mesotheliomas.
Jena-Muenchen4 (JM4) Rabbit Polyclonal
Keratin 5 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E13820
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to aa 165-178 of human JM4.
E13822
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human cytokeratin 5.
1.0ml
Concentrate
Application: IHC-P
E13824
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E13821
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E14000
0.1ml
Concentrate
E14002
0.5ml
E14004 E14001
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain
Control Tissue: Breast, Mesothelioma, Prostate, Skin
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm
Human Brain stained with anti-Jena-Muenchen4 (JM4) antibody E1400
Human Skin stained with anti-Keratin 5 antibody E1382
Product Description: JM4 is a 19kDa four-transmembrane protein binding to the CCR5 receptor. It plays a role in the regulation of intracellular protein transport. It is expressed in normal brain, small intestine, lung, spleen, and pancreas and has also been detected in tumors of breast, colon, lung, and ovary.
62
Clone: N/A
Product Description: Twenty human keratins are divided into acidic and basic subfamilies. Members of the acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Human keratins are useful markers in cancer research. Cytokeratin 5 is expressed in breast myoepithelia cells, prostate basal cells, most epithelial and biphasic mesotheliomas.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Keratin 6 Rabbit Monoclonal
Keratin 7 Rabbit Polyclonal Clone: SP87
Catalog No.
Size
Format
E18000
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human keratin 6 protein.
E18002
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human cytokeratin 7.
1.0ml
Concentrate
Application: IHC-P, WB
E18004
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18001
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3870
0.1ml
Concentrate
M3872
0.5ml
M3874 M3871
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate, Skin
Control Tissue: Breast Carcinoma, Ovarian Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Control Lysate: A431 Molecular Weight: 60 kDa
Control Lysate: HeLa
Human Prostate Carcinoma stained with anti-Keratin 6 antibody M387
Human Breast Carcinoma stained with anti-Keratin 7 antibody E1800
Molecular Weight: 54 kDa
Product Description: Cytokeratin 6 (CK6) and 16 (CK16) are expressed in keratinocytes, which undergo rapid turnover in the suprabasal region. CK6 is found in basal cells of prostate glands, hair follicles, suprabasal cells of a variety of internal stratified epithelia and in epidermis. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas.
Product Description: Cytokeratin 7 (CK7) is a basic cytokeratin which is found in most glandular and transitional epithelia but not in the stratified squamous epithelia. Cytokeratin 7 is expressed in the epithelial cells of ovary, lung, and breast but not of colon, prostate, or gastrointestinal tract.
Keratin 6 Rabbit Polyclonal
Keratin 8 Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M4020
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human cytokeratin 6 protein.
M4022
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human keratin 8.
1.0ml
Concentrate
Application: IHC-P
M4024
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M4021
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18880
0.1ml
Concentrate
E18882
0.5ml
E18884 E18881
Clone: SP102
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate, Skin
Control Tissue: Breast Ductal Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Human Prostate stained with anti-Keratin 6 antibody E1888
Human Breast Ductal Carcinoma stained with anti-Keratin 8 antibody M402
Product Description: Cytokeratin 6 (CK6) and 16 (CK16) are expressed in keratinocytes, which undergo rapid turnover in the suprabasal region. CK6 is found in basal cells of prostate glands, hair follicles, suprabasal cells of a variety of internal stratified epithelia and in epidermis. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas.
Product Description: Keratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in association with keratin 18. Keratin 8 is primarily found in the non-squamous epithelia. It is present in hepatocellular carcinomas and the majority of adenocarcinomas and ductal carcinomas, but it is absent in squamous cell carcinomas.
Keratin 7** Rabbit Monoclonal
Keratin 8 Rabbit Polyclonal
Clone: SP52
Catalog No.
Size
Format
E3260
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human cytokeratin 7.
E3262
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 1-483 of human cytokeratin 8.
1.0ml
Concentrate
Application: IHC-P, WB
E3264
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3261
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3520
0.1ml
Concentrate
M3522
0.5ml
M3524 M3521
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Ovarian Carcinoma
Control Tissue: Breast Carcinoma, Lung, Skin
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Control Lysate: HeLa
Control Lysate: HeLa
Molecular Weight: 54 kDa
Molecular Weight: 52 kDa
Human Breast Carcinoma stained with anti-Keratin 7 antibody M352
Human Lung stained with anti-Keratin 8 antibody E326
Product Description: Cytokeratin 7 (CK7) is a basic cytokeratin which is found in most glandular and transitional epithelia but not in the stratified squamous epithelia. Cytokeratin 7 is expressed in the epithelial cells of ovary, lung, and breast but not in colon, prostate, or gastrointestinal tract.
Product Description: Keratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in association with keratin 18. Keratin 8 is primarily found in the non-squamous epithelia. It is present in hepatocellular carcinomas and the majority of adenocarcinomas and ductal carcinomas, but it is absent in squamous cell carcinomas.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
63
Keratin 8 Rabbit Polyclonal
Keratin 14 Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3530
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from the human cytokeratin 8.
M3532
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human cytokeratin 14.
1.0ml
Concentrate
Application: IHC-P
M3534
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3531
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18400
0.1ml
Concentrate
E18402
0.5ml
E18404 E18401
Clone: SP53
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Colon Carcinoma
Control Tissue: Prostate, Skin, Squamous Cell Carcinoma
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm Control Lysate: A431 Molecular Weight: 50 kDa
Human Colon Carcinoma stained with anti-Keratin 8 antibody E1840
Human Prostate stained with anti-Keratin 14 antibody M353
Product Description: Keratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in association with keratin 18. Keratin 8 is primarily found in the non-squamous epithelia. It is present in hepatocellular carcinomas and the majority of adenocarcinomas and ductal carcinomas, but it is absent in squamous cell carcinomas.
Product Description: Cytokeratin 14 (CK14) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 5.
Keratin 10** Rabbit Monoclonal
Keratin 14 Rabbit Polyclonal
Clone: SP99
Catalog No.
Size
Format
E2620
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human keratin 10.
E2622
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human cytokeratin 14.
1.0ml
Concentrate
Application: IHC-P
E2624
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2621
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3990
0.1ml
Concentrate
M3992
0.5ml
M3994 M3991
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Skin
Control Tissue: Skin, Squamous Cell Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Skin stained with anti-Keratin 10 antibody M399
Human Skin stained with anti-Keratin 14 antibody E262
Product Description: Cytokeratin 10 is a type I cytokeratin, expressed by suprabasal cells of stratified and cornified epithelia. Its defects are implicated in bullous congenital ichthyosiform erythroderma, epidermolytic hyperkeratosis and diffuse nonepidermolytic palomoplantar keratoderma.
Product Description: Cytokeratin 14 (CK14) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 5.
Keratin 10 Rabbit Polyclonal
Keratin 17** Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3950
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human keratin 10 protein.
M3952
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
M3954
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3951
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18980
0.1ml
Concentrate
E18982
0.5ml
E18984 E18981
Isotype: Rabbit IgG Control Tissue: Skin Cellular Localization: Cytoplasm
Clone: SP95 Immunogen: Synthetic peptide corresponding to C-terminus of human keratin 17 protein. Application: IHC-P, WB Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Prostate Carcinoma Cellular Localization: Cytoplasm Control Lysate: HeLa Molecular Weight: 48 kDa
Human Skin stained with anti-Keratin 10 antibody E1898
Product Description: Cytokeratin 10 is a type I cytokeratin, expressed by suprabasal cells of stratified and cornified epithelia. Its defects are implicated in bullous congenital ichthyosiform erythroderma, epidermolytic hyperkeratosis and diffuse nonepidermolytic palomoplantar keratoderma.
64
Human Prostate Carcinoma stained with anti-Keratin 17 antibody M395
Product Description: Cytokeratin 17 (CK17) plays a role in the formation and maintenance of various skin appendages cytokeratin 17 is expressed in the outer root sheath and medulla region of hair follicle from mucosal stratified squamous epithelia, basal cells of oral epithelium, palmoplantar epidermis, and sweat and mammary glands. It is also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Keratin 17 Rabbit Polyclonal
Keratin 18 Mouse Monoclonal Clone: N/A
Catalog No.
Size
Format
E17010
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of cytokeratin 17 protein.
E17012
0.5ml
Concentrate
Immunogen: Human breast cancer PMC42 cells.
1.0ml
Concentrate
Application: IHC-P, WB
E17014
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E17011
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18920
0.1ml
Concentrate
E18922
0.5ml
E18924 E18921
Clone: DC10
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Mouse IgG1
Control Tissue: Lung Adenocarcinoma, Prostate Carcinoma
Control Tissue: Breast Carcinoma, Skin
Cellular Localization: Cytoplasm
Control Lysate: A431
Cellular Localization: Cytoplasm
Control Lysate: HeLa
Molecular Weight: 48 kDa
Molecular Weight: 48 kDa Human Lung Adenocarcinoma stained with anti-Keratin 17 antibody E1892
Human Breast Carcinoma stained with anti-Keratin 18 antibody E1701
Product Description: Cytokeratin 17 (CK17) plays a role in the formation and maintenance of various skin appendages cytokeratin 17 is expressed in the outer root sheath and medulla region of hair follicle from mucosal stratified squamous epithelia, basal cells of oral epithelium, palmoplantar epidermis, and sweat and mammary glands. It is also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix.
Product Description: Cytokeratin 18 (CK18), which belongs to the type A (acidic) subfamily of low molecular weight keratins exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14.
Keratin 18 Rabbit Monoclonal
Keratin 18 Mouse Monoclonal Clone: SP69
Catalog No.
Size
Format
E16540
0.1ml
Concentrate
Immunogen: Human breast cancer PMC42 cells
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human cytokeratin 18.
E16542
0.5ml
Concentrate
Concentrate
Application: IHC-P, WB
Application: IHC-P
1.0ml
E16544
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E16541
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
M3690
0.1ml
Concentrate
M3692
0.5ml
M3694 M3691
Isotype: Rabbit IgG
Clone: SPM510
Isotype: Mouse IgG1 Control Tissue: Breast Carcinoma, Skin
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm Control Lysate: A431 Molecular Weight: 48 kDa Human Breast Carcinoma stained with anti-Keratin 18 antibody M369
Human Skin stained with anti-Keratin 18 antibody E1654
Product Description: Cytokeratin 18 (CK18), which belongs to the type A (acidic) subfamily of low molecular weight keratins exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14.
Product Description: Cytokeratin 18 (CK18), which belongs to the type A (acidic) subfamily of low molecular weight keratins exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14.
Keratin 18 Rabbit Polyclonal
Keratin 19 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2630
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human cytokeratin 18
E2632
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human cytokeratin 19.
1.0ml
Concentrate
Application: IHC-P, WB
E2634
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2631
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18330
0.1ml
Concentrate
E18332
0.5ml
E18334 E18331
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Skin
Control Tissue: Skin
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Control Lysate: A431 Molecular Weight: 48 kDa Human Breast Carcinoma stained with anti-Keratin 18 antibody E1833
Product Description: Cytokeratin 18 (CK18), which belongs to the type A (acidic) subfamily of low molecular weight keratins exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14.
Human Skin stained with anti-Keratin 19 antibody E263
Product Description: Cytokeratin 19 (CK19) is a member of type I acidic subfamily of intermediate filaments. It is expressed in various different human tissues except in liver. Cytokeratin 19 is not expressed in hepatocytes.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
65
Keratin 20** Rabbit Monoclonal
Ki-67 Rabbit Polyclonal
Clone: SP33
Catalog No.
Size
Format
E1870
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human cytokeratin 20.
E1872
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from the human Ki-67 protein.
1.0ml
Concentrate
Application: IHC-P
E1874
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E1871
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3330
0.1ml
Concentrate
M3332
0.5ml
M3334 M3331
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma
Control Tissue: Breast Carcinoma, Lymph Node, Tonsil
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus
Human Colon Carcinoma stained with anti-Keratin 20 antibody M333
Human Tonsil stained with anti-Ki-67 antibody E187
Product Description: Cytokeratin 20 (CK20) is a Type-I keratin primarily expressed in gastric and intestinal epithelium, urothelium, and Merkel-cells. CK20 is expressed in adenocarcinomas of the colon, stomach, pancreas and the bile system, mucinous ovarian tumors, transitional-cell, and Merkel-cell carcinomas. CK20 is negative in squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium, non-mucinous tumors of the ovary, and small cell carcinomas.
Product Description: Ki-67 is a nuclear protein which is expressed in the proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.
Keratin 20 Rabbit Polyclonal
KOC/L523S Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18310
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human cytokeratin 20.
E18312
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human KOC/L523S.
1.0ml
Concentrate
Application: IHC-P
E18314
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18311
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16440
0.1ml
Concentrate
E16442
0.5ml
E16444 E16441
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma
Control Tissue: Placenta, Prostate Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Colon Carcinoma stained with anti-Keratin 20 antibody E1644
Human Prostate Carcinoma stained with anti-KOC/L523S antibody E1831
Product Description: Cytokeratin 20 (CK20) is a Type-I keratin primarily expressed in gastric and intestinal epithelium, urothelium, and Merkel-cells. CK20 is expressed in adenocarcinomas of the colon, stomach, pancreas and the bile system, mucinous ovarian tumors, transitional-cell, and Merkel-cell carcinomas. CK20 is negative in squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium, non-mucinous tumors of the ovary, and small cell carcinomas.
Product Description: Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein (KOC), is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed in some malignancies such as melanoma but not in benign nevi. IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi. IMP-3 appears to be involved in the progression of malignant melanoma.
Ki-67 Rabbit Monoclonal
k-Ras Rabbit Polyclonal Clone: SP6
Catalog No.
Size
Format
E17960
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human Ki-67 protein.
E17962
0.5ml
Concentrate
Immunogen: Synthetic peptide from internal region of human k-Ras protein.
1.0ml
Concentrate
Application: IHC-P
E17964
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*, Mouse*
E17961
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3060
0.1ml
Concentrate
M3062
0.5ml
M3064 M3061
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Bladder, Breast, Prostate Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Membrane
Human Tonsil stained with anti-Ki-67 antibody M306
Human Prostate Carcinoma stained with anti-k-Ras antibodyy E1796
Product Description: Ki-67 is a nuclear protein which is expressed in the proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.
66
Clone: N/A
Product Description: The guanine-nucleotide binding proteins (K-Ras, H-Ras and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms. Receptor tyrosine kinases and G-protein-coupled receptors activate Ras. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp (G12D).
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Ku80 Rabbit Polyclonal
Lamin B Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E13490
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human Ku80 protein.
E13492
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human lamin B.
1.0ml
Concentrate
Application: IHC-P
E13494
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E13491
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19120
0.1ml
Concentrate
E19122
0.5ml
E19124 E19121
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta
Control Tissue: Breast Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Nucleus Envelope Control Lysate: HepG2 Molecular Weight: 67 kDa
Human Placenta stained with anti-Ku80 antibody E1912
Human Breast Carcinoma stained with anti-Lamin B antibody E1349
Product Description: X-ray repair cross-complementing protein 5 (XRCC5), alternative name (Ku80), is a single stranded DNA-dependent ATP-dependent helicase. Ku80, along with Ku70 forms a heterodimeric protein and Ku80 is a widely expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks. The inhibition of Ku80 can damage the DNA repair pathway of tumor cells and potentially increase the killing of cancer cells.
Product Description: Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing: lamin A, lamin C and lamin Adel10. While the B-type lamins include two proteins arising from two distinct genes: lamin B1 and lamin B2.
Ku80 Rabbit Polyclonal
Lewis A Mouse Monoclonal Clone: N/A
Catalog No.
Size
Format
E17380
0.1ml
Concentrate
Immunogen: Mucin isolated from an ovarian cyst.
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human Ku80 protein.
E17382
0.5ml
Concentrate
Concentrate
Application: IHC-P
Application: IHC-P
1.0ml
E17384
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E17381
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E19110
0.1ml
Concentrate
E19112
0.5ml
E19114 E19111
Isotype: Rabbit IgG
Clone: SPM522
Isotype: Mouse IgG1 Control Tissue: Colon Carcinoma
Control Tissue: Placenta
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus
Human Placenta stained with anti-Ku80 antibody E1911
Human Colon Carcinoma stained with anti-Lewis A antibody E1738
Product Description: X-ray repair cross-complementing protein 5 (XRCC5), alternative name (Ku80), is a single stranded DNA-dependent ATP-dependent helicase. Ku80, along with Ku70 forms a heterodimeric protein and Ku80 is a widely expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks. The inhibition of Ku80 can damage the DNA repair pathway of tumor cells and potentially increase the killing of cancer cells.
Product Description: Lewis A is a blood group antigen consisting of Gal Beta1-3 (Fuc alpha1-4) GlcNAc. Lewis A is found to be present primarily on epithelial cells such as colon and kidneys.
Lambda Light Chain Rabbit Polyclonal
LIMD1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18700
0.1ml
Concentrate
Concentrate
Immunogen: Free lambda light chain from pooled human IgG lambda myeloma sera.
E18702
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human LIMD1 protein.
1.0ml
Concentrate
Application: IHC-P, WB
E18704
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18701
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19200
0.1ml
Concentrate
E19202
0.5ml
E19204 E19201
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Lung, Lung Carcinoma
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm, Nucleus
Control Lysate: Human Spleen Molecular Weight: 25 kDa Human Tonsil stained with anti-Lambda Light Chain antibody E1920
Product Description: Lambda light chains are polypeptide chains located in the cell membrane and cytoplasmic regions of normal B cells and plasma cells. The combination of lambda light chains and heavy chains forms immunoglobulin molecules. There are two classes of light chains found in immunoglobulins: kappa light chains and lambda light chains. Light chain production by lymphoid cells is genetically restricted to single light chain class.
Human Lung Carcinoma stained with anti-LIMD1 antibody E1870
Product Description: The Zyxin family of proteins contains five members: Ajuba, LIMD1, LPP, TRIP6 and Zyxin. LIMD1 is a ubiquitously expressed tumor suppressor. LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions. LIMD1 was first identified when the deletion of its gene was noted in some cervical cancers. LIMD1 blocks tumor growth and is downregulated in lung cancer.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
67
Lipocalin-2 Rabbit Polyclonal
LMO2 Mouse Monoclonal Clone: N/A
Catalog No.
Size
Format
E17650
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from near N-terminus of human lipocalin-2 protein.
E17652
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to human LMO2 protein.
1.0ml
Concentrate
Application: IHC-P
E17654
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E17651
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18810
0.1ml
Concentrate
E18812
0.5ml
E18814 E18811
Clone: 1A9-3D11
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Mouse IgG1
Control Tissue: Breast Carcinoma, Stomach Carcinoma
Control Tissue: Hodgkin’s Lymphoma, Tonsil
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus
Human Stomach Carcinoma stained with anti-Lipocalin-2 antibody E1881
Human Tonsil stained with anti-LMO2 antibody E1765
Product Description: Lipocalin 2 is a member of the lipocalin family which encompass more than 25 members (including proteins like retinol binding protein, a1 microglobulin, b lactoglobulin, apolipoprotein D and odorant binding protein). The members of the lipocalin family are characterized by their ability to bind small lipophilic substances in their hydrophobic core, and thereby serve as transporters of substances.
Product Description: LMO-2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO-2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO-2 transcription start site is located approximately 25 kb downstream from the 11p13 T cell translocation cluster (11p13 ttc), where T cell acute lymphoblastic leukemia-specific translocations occur.
LMO2** Rabbit Monoclonal
Luteinizing Hormone (LH) Rabbit Polyclonal
Catalog No.
Size
Format
M3510
0.1ml
Concentrate
M3512
0.5ml
Concentrate
M3514
1.0ml
Concentrate
M3511
7.0ml
Ready-to-Use
Clone: SP51
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to near N-terminus of human LMO2 protein.
E17480
0.1ml
Concentrate
Immunogen: Purified human luteinizing hormone.
E17482
0.5ml
Concentrate
Application: IHC-P
E17484
1.0ml
Concentrate
Application: IHC-P, WB
E17481
7.0ml
Ready-to-Use
Species Reactivity: Human*
Species Reactivity: Human*
Clone: N/A
Isotype: Rabbit IgG Control Tissue: Anterior Pituitary
Isotype: Rabbit IgG
Cellular Localization: Cytoplasm
Control Tissue: Hodgkin’s Lymphoma, Tonsil Cellular Localization: Nucleus Control Lysate: Ramos Molecular Weight: 24 kDa Human Tonsil stained with anti-LMO2 antibody M351
Human Anterior Pituitary stained with anti-Luteinizing Hormone (LH) antibody E1748
Product Description: LMO-2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO-2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO-2 transcription start site is located approximately 25 kb downstream from the 11p13 T cell translocation cluster (11p13 ttc), where T cell acute lymphoblastic leukemia-specific translocations occur.
Product Description: LH is a tropic hormone which modulates the secretory activity of other endocrine glands. It is produced in the anterior hypophysis of the pituitary gland. The glycoprotein hormone, LH, like follicle stimulating hormone and thyroid stimulating hormone, is composed of a common alpha-subunit but also a specific beta-subunit, which characterizes each of these hormones.
LMO2 Rabbit Polyclonal
MAGE-1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E4500
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to human LMO2 protein.
E4502
0.5ml
Concentrate
Immunogen: Full length recombinant human MAGE-1 protein.
1.0ml
Concentrate
Application: IHC-P
E4504
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4501
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17830
0.1ml
Concentrate
E17832
0.5ml
E17834 E17831
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Hodgkin’s Lymphoma, Tonsil
Control Tissue: Melanoma, Testis
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm
Human Tonsil stained with anti-LMO2 antibody E1783
Human Melanoma stained with anti-MAGE-1 antibody E450
Product Description: LMO-2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO-2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO-2 transcription start site is located approximately 25 kb downstream from the 11p13 T cell translocation cluster (11p13 ttc), where T cell acute lymphoblastic leukemia-specific translocations occur.
68
Clone: N/A
Product Description: Melanoma-associated antigen 1 (MAGE-1) genes encode an important group of antigens. MAGE-1 is expressed on a significant proportion of human neoplasms such as melanoma, brain glial tumors, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, and renal cell carcinomas, but not on kidney tumor, leukemias and lymphomas.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies MALT-1 Rabbit Polyclonal
MCL-1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2640
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human MALT-1 protein.
E2642
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human MCL-1.
1.0ml
Concentrate
Application: IHC-P, WB
E2644
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2641
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18900
0.1ml
Concentrate
E18902
0.5ml
E18904 E18901
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: B Cell Lymphoma, Lymph Node, Tonsil
Control Tissue: Tonsil Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Cytoplasm, Nucleus Control Lysate: HeLa Molecular Weight: 90 kDa Human B Cell Lymphoma stained with anti-MALT-1 antibody E1890
Human Tonsil stained with anti-MCL-1 antibody E264
Product Description: Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT-1) has two alternatively spliced transcript variants encoding different isoforms. Isoform a is protein of 824 amino acids, and isoform b is a protein of 813 amino acids. MALT-1 is thought to play a role in NF kappaB signaling by enchancing NF kappaB activation through interaction with BCL-10. Interaction between MALT-1 and BCL-10 mediates IKK activation in vitro.
Product Description: Myeloid cell leukemia-1 (MCL-1) is a member of the BCL-2 family. The carboxy terminal of MCL-1 and BCL-2 share significant sequence homology. Expression of MCL-1 is increased upon exposure of ML-1 cells to ionizing radiation, ultraviolet radiation, and alkylating drugs along with increases in GADD45 and Bax and a decrease in BCL-2. Like BCL-2, MCL-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis.
Mammaglobin Rabbit Polyclonal
MCM2 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3850
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to human mammmaglobin protein.
M3852
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
M3854
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3851
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16400
0.1ml
Concentrate
E16402
0.5ml
E16404 E16401
Clone: SP85 Immunogen: Synthetic peptide derived from internal region of human MCM2 protein. Application: IHC-P, WB Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Rectal Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus Control Lysate: HeLa Molecular Weight: 130 kDa
Human Breast Carcinoma stained with anti-Mammaglobin antibody E1640
Human Rectal Carcinoma stained with anti-MCM2 antibody M385
Product Description: The mammaglobin gene was first identified using a differential screening approach directed at the isolation of novel, human breast cancer-associated genes. Mammaglobin encodes a 10kDa glycoprotein and is distantly related to a family of epithelial secretory proteins. Mammaglobin is overexpressed in human breast cancer. Mammaglobin is a relatively specific mammary marker.
Product Description: The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4(CDC21), MCM5(CDC46), MCM6(Mis5) and MCM7(CDC47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. MCM2/MCM4 complexes function as substrates for CDC2/ cyclin B in vitro.
MART-1/Melan-A Rabbit Polyclonal
MCM2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Recombinant human MART-1 protein.
E18730
0.1ml
Concentrate
Concentrate
Application: IHC-P
E18732
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human MCM2 protein.
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
Ready-to-Use
Species Reactivity: Human*
E18734
7.0ml
E18731
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2830
0.1ml
E2832
0.5ml
E2834 E2831
Isotype: Rabbit IgG
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Control Tissue: Melanoma Cellular Localization: Cytoplasm
Control Tissue: Rectal Carcinoma
Human Melanoma stained with anti-MART-1/Melan-A antibody E283
Human Rectal Carcinoma stained with anti-MCM2 antibody E1873
Product Description: MART-1 / Melan-A is a melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-1 tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum.
Cellular Localization: Nucleus
Product Description: The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4(CDC21), MCM5(CDC46), MCM6(Mis5) and MCM7(CDC47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. MCM2/MCM4 complexes function as substrates for CDC2/ cyclin B in vitro.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
69
MCM2 Rabbit Polyclonal
MDGI Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18620
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human MCM2 protein.
E18622
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human MDGI protein.
1.0ml
Concentrate
Application: IHC-P
E18624
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18621
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12480
0.1ml
Concentrate
E12482
0.5ml
E12484 E12481
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Colon Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm
Human Breast Carcinoma stained with anti-MCM2 antibody E1248
Human Colon Carcinoma stained with anti-MDGI antibody E1862
Product Description: The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4(CDC21), MCM5(CDC46), MCM6(Mis5) and MCM7(CDC47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. MCM2/MCM4 complexes function as substrates for CDC2/ cyclin B in vitro.
Product Description:MDGI/FABP3 is a small cytosolic protein responsible for the transport and deposition of fatty acids inside the cell.
MCM5 Rabbit Polyclonal
MDM2 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E3500
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 1-150 of human MCM5.
E3502
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human MDM2 protein.
1.0ml
Concentrate
Application: IHC-P
E3504
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3501
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E13830
0.1ml
Concentrate
E13832
0.5ml
E13834 E13831
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate
Control Tissue: Breast Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Prostate stained with anti-MCM5 antibody E1383
Human Breast Carcinoma stained with anti-MDM2 antibody E350
Product Description: MCM5 (Mini Chromosome Maintainance protein-5) is involved in the control of DNA replication. MCM proteins have DNA dependent ATPase motifs in their central domain which is conserved from yeast to mammals. MCM proteins form a complex which exhibits ATPase and helicase activities. G0 phase levels of MCM2 and MCM5 are lower than that of MCM7 and MCM3 but increase as the cell enters G1/S phase of the cell cycle.
Product Description: Human homolog of murine double minute-2 (MDM2) and p53 function in mutual regulation: activation of p53 results in expression of MDM2 which consequently inhibits the ability of wild type p53 to stimulate expression of target genes. MDM2 is frequently overexpressed in the nuclei of soft tissue sarcomas, and to a much lesser extent in a wide variety of malignancies of bladder, breast, testis, cervix, glial cells.
MDGI Rabbit Polyclonal
MEF-2 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E12390
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human MDGI protein.
E12392
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to aa 487-507 of human MEF-2.
1.0ml
Concentrate
Application: IHC-P
E12394
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E12391
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18670
0.1ml
Concentrate
E18672
0.5ml
E18674 E18671
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma
Control Tissue: Brain
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus
Human Colon Carcinoma stained with anti-MDGI antibody E1867
Human Brain stained with anti-MEF-2 antibody E1239
Product Description: MDGI/FABP3 is a small cytosolic protein responsible for the transport and deposition of fatty acids inside the cell.
70
Clone: N/A
Product Description:The myocyte enhancer factors-2 (MEF-2) family of transcription factors associate with a variety of co-repressors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four distinct family members arise from alternatively splices transcripts, termed MEF-2A, MEF-2B, MEF-2C, and MEF2D. These members bind as homo- and heterodimers to the MEF2 site in the promoter region of affected genes.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Melanoma (gp100) Rabbit Polyclonal
mGluR1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2890
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 1-150 human gp100.
E2892
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human mGluR1.
1.0ml
Concentrate
Application: IHC-P
E2894
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2891
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4450
0.1ml
Concentrate
E4452
0.5ml
E4454 E4451
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Melanoma
Control Tissue: Brain
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Melanoma stained with anti-Melanoma (gp100) antibody E445
Human Brain stained with anti-mGluR1 antibody E289
Product Description: By immunohistochemistry, this antibody specifically recognizes a protein in melanocytes and melanomas. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.
Product Description: Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-3, KAI-2) which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors, which when activated can activate phopholipases or adenylylcyclase.
Mesothelin Rabbit Monoclonal
mGluR5 Rabbit Polyclonal
Clone: SP74
Catalog No.
Size
Format
E2870
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human mesothelin protein.
E2872
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human mGluR5.
1.0ml
Concentrate
Application: IHC-P
E2874
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2871
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3740
0.1ml
Concentrate
M3742
0.5ml
M3744 M3741
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Mesothelioma
Control Tissue: Brain
Cellular Localization: Membrane
Cellular Localization: Cytoplasm
Human Mesothelioma stained with anti-Mesothelin antibody M374
Human Brain stained with anti-mGluR5 antibody E287
Product Description: Mesothelin is a glycocylphosphotidylianositol-linked cell-surface glycoprotein that is present on the surface of normal mesothelium and is overexpressed in epithelial ovarian cancer and malignant mesotheliomas.
Product Description: Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-3, KAI-2) which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors, which when activated can activate phopholipases or adenylylcyclase.
Mesothelin Rabbit Polyclonal
Microphthalmia (MiTF) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E17900
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from the human mesothelin.
E17902
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to human MiTF.
1.0ml
Concentrate
Application: IHC-P
E17904
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E17901
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18390
0.1ml
Concentrate
E18392
0.5ml
E18394 E18391
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Mesothelioma
Control Tissue: Melanoma
Cellular Localization: Membrane
Cellular Localization: Nucleus
Human Mesothelioma stained with anti-Mesothelin antibody E1839
Human Melanoma stained with anti-Microphthalmia (MiTF) antibody E1790
Product Description: Mesothelin is a glycocylphosphotidylianositol-linked cell-surface glycoprotein that is present on the surface of normal mesothelium and is overexpressed in epithelial ovarian cancer and malignant mesotheliomas.
Product Description: Microphthalmia associated transcription factor (MiTF) is a basic helix-loop-helix leucine zipper transcription factor implicated in pigmentation, mast cells and bone development. There are two known isoforms of MiTF. The shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer Mi form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melonoma cells, as well as mast cells and heart.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
71
MIP-1 alpha Rabbit Polyclonal
MMP-2 (72kDa Collagenase IV) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18010
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human MIP-1 alpha.
E18012
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from near N-terminus of human MMP-2 protein.
1.0ml
Concentrate
Application: IHC-P
E18014
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18011
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12680
0.1ml
Concentrate
E12682
0.5ml
E12684 E12681
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung Cellular Localization: Cytoplasm, Membrane
Control Tissue: Bladder, Breast, Ovarian Carcinoma, Placenta
Human Lung stained with anti-MIP-1 alpha antibody E1268
Human Placenta stained with anti-MMP-2 (72kDa Collagenase IV) antibody E1801
Cellular Localization: Cytoplasm
Product Description: Macrophage inflammatory protein-1a (MIP-1a) is an 8kDa member of the C-C chemokine subfamily. C-C chemokines are chemoattractants and activators for monocytes and T cells. MIP-1a has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1b and RANTES.
Product Description: MMPs are proteolytic enzymes capable of degrading connective tissue components. They have a common mode of activation, a conserved amino acid sequence in the putative metal-binding active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP-2 is activated by cleavage of the first 80 amino acids. This antibody reacts with both latent and active MMP-2.
MLH1 Rabbit Polyclonal
MMP-3 (Stromelysin-1) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E12670
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human MLH1 protein.
E12672
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 251478 of human MMP-3.
1.0ml
Concentrate
Application: IHC-P
E12674
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E12671
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17810
0.1ml
Concentrate
E17812
0.5ml
E17814 E17811
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Rectal Carcinoma
Control Tissue: Placenta
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm
Human Colon Carcinoma stained with anti-MLH1 antibody E1781
Human Placenta stained with anti-MMP-3 (Stromelysin-1) antibody E1267
Product Description: MUTL protein homolog 1 (MLH1) is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintain the integrity of genetic information. An alteration of microsatellite repeats due to strand misalignment during DNA replication is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis.
Product Description: Matrix metalloproteinases (MMP) are proteolytic enzymes capable of degrading connective tissue components. Imbalanced secretion of certain MMP or disturbances in the differential control of MMP by tissue inhibitor of MMPs (TIMPs) is implicated in the invasive potential of malignant tumors. Stromelysin (MMP3/Transin) degrades several matrix components including the core proteins of proteoglycans, laminin and non-helical regions of collagens.
MMP-1 Rabbit Polyclonal
MMP-9 (92kDa Collagenase IV) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E3660
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from near C-terminus of human MMP-1 protein.
E3662
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from near C-terminus of human MMP-9 protein.
1.0ml
Concentrate
Application: IHC-P
E3664
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3661
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3570
0.1ml
Concentrate
E3572
0.5ml
E3574 E3571
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bladder, Breast, Ovarian Carcinoma, Placenta
Control Tissue: Breast Carcinoma, Placenta
Cellular Localization: Cytoplasm
Human Placenta stained with anti-MMP-1 antibody E357
Product Description: Matrix metalloproteinases (MMP) are proteolytic enzymes capable of degrading connective tissue components. Imbalanced secretion of certain MMP or disturbances in the differential control of MMP by tissue inhibitor of MMPs (TIMPs) is implicated in the invasive potential of tumors. MMP-1, MMP2, and MMP-9 dissolve extracellular matrix (ECM) and may initiate and promote angiogenesis.
72
Clone: N/A
Cellular Localization: Cytoplasm
Human Placenta stained with anti-MMP-9 (92kDa Collagenase IV) antibody E366
Product Description: MMPs are proteolytic enzymes capable of degrading connective tissue components. They have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. This antibody reacts with both latent and active MMP-9.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies MMP-10 (Stromelysin-2) Rabbit Polyclonal
MMP-19 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4030
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from the hinge domain of human MMP-10 protein.
E4032
0.5ml
Concentrate
Immunogen: Synthetic peptide from N-terminus of human MMP-19 protein.
1.0ml
Concentrate
Application: IHC-P
E4034
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4031
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3670
0.1ml
Concentrate
E3672
0.5ml
E3674 E3671
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Placenta
Control Tissue: Placenta
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Placenta stained with anti-MMP-10 (Stromelysin-2) antibody E367
Human Placenta stained with anti-MMP-19 antibody E403
Product Description: MMPs are proteolytic enzymes capable of degrading connective tissue components. They have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. This antibody reacts with both latent and active MMP-10.
Product Description: MMPs are proteolytic enzymes capable of degrading connective tissue components. They have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP-19 is the target of autoantibodies in rheumatoid arthritis and SLE.
MMP-14/MT1-MMP Rabbit Polyclonal
MMP-23 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4040
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human MMP-14 protein.
E4042
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human MMP-23 protein.
1.0ml
Concentrate
Application: IHC-P
E4044
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4041
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3860
0.1ml
Concentrate
E3862
0.5ml
E3864 E3861
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Placenta
Control Tissue: Placenta
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Placenta stained with anti-MMP-14/MT1-MMP antibody E386
Human Placenta stained with anti-MMP-23 antibody E404
Product Description: MMPs are a group of enzymes involved in matrix degradation. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively, contain a C-terminus transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MMP-14 cleaves progelatinase A (MMP-2) and progelatinase B to their active forms and it gets activated through the membrane plasmin cascade.
Product Description: MMPs are proteolytic enzymes capable of degrading connective tissue components. They have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play a significant role in regulating angiogenesis. MMP-23 transcripts have been detected in reproductive organs like ovary, testis and prostate. MMP-23 is inhibited by TIMP-1.
MMP-15/MT2-MMP Rabbit Polyclonal
MSH2 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size Format
Clone: SP46
M3460
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from the catalytic domain of mouse MMP-15/MT2-MMP protein.
M3462
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human MSH2.
1.0ml
Concentrate
Application: IHC-P
M3464
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3461
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E4120
0.1ml
Concentrate
E4122
0.5ml
E4124 E4121
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta
Control Tissue: Colon Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus
Human Placenta stained with anti-MMP-15/MT2-MMP antibody E412
Human Colon Carcinoma stained with anti-MSH2 antibody M346
Product Description: MMPs are a group of enzymes involved in matrix degradation. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminus transmembrane domain anchoring them to the cell surface. MMP15 plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. MMP14 and MMP15 can be coexpressed in advanced stages of breast carcinoma.
Product Description: MSH2 as a mismatch repair protein is involved in DNA repair. Mutations of MSH2 are found in approximately 50% of inherited non polyposis colorectal carcinoma (HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma and cancers of the gastrointestinal, urological and female reproductive tracts.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
73
MSH2 Rabbit Polyclonal
MSH6 Mouse Monoclonal Clone: N/A
Catalog No.
Size
Format
E18370
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human MSH2.
E18372
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human MSH6 protein.
1.0ml
Concentrate
Application: IHC-P
E18374
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18371
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17790
0.1ml
Concentrate
E17792
0.5ml
E17794 E17791
Clone: SPM525
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Mouse IgG1/k
Control Tissue: Colon Carcinoma
Control Tissue: Colon Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Colon Carcinoma stained with anti-MSH2 antibody E1779
Human Colon Carcinoma stained with anti-MSH6 antibody E1837
Product Description: MSH2 as a mismatch repair protein is involved in DNA repair. Mutations of MSH2 are found in approximately 50% of inherited non polyposis colorectal carcinoma (HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma and cancers of the gastrointestinal, urological and female reproductive tracts.
Product Description: MSH6 as a mismatch repair protein is central to mismatch DNA repair. Mutations of MSH6 are found in inherited non polyposis colorectal carcinoma (HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma and cancers of the gastrointestinal, urological and female reproductive tracts.
MSH3 Rabbit Polyclonal
MSH6 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E17670
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human MSH3 protein.
E17672
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human MSH6 protein.
1.0ml
Concentrate
Application: IHC-P
E17674
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E17671
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18940
0.1ml
Concentrate
E18942
0.5ml
E18944 E18941
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Rectal Carcinoma
Control Tissue: Colon Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Rectal Carcinoma stained with anti-MSH3 antibody E1894
Human Colon Carcinoma stained with anti-MSH6 antibody E1767
Product Description: MSH3 belongs to the MutS DNA mismatch repair family although its precise function in mammals is still unknown. Yeast MSH3 is thought to act in a complex with MSH2 to recognize DNA insertion/deletion mispairs.
Product Description: MSH6 as a mismatch repair protein is central to mismatch DNA repair. Mutations of MSH6 are found in inherited non polyposis colorectal carcinoma (HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma and cancers of the gastrointestinal, urological and female reproductive tracts.
MSH6 Rabbit Monoclonal
mTOR Rabbit Polyclonal
Catalog No.
Size
Format
M3930
0.1ml
Concentrate
M3932
0.5ml
Concentrate
M3934
1.0ml
Concentrate
M3931
7.0ml
Ready-to-Use
Clone: SP93
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to internal region of human MSH6 protein.
E18590
0.1ml
Concentrate
E18592
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human mTOR protein.
E18594
1.0ml
Concentrate
Application: IHC-P, WB
Application: IHC-P
E18591
7.0ml
Ready-to-Use
Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Rectal Carcinoma Cellular Localization: Nucleus
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Breast Carcinoma Cellular Localization: Cytoplasm, Membrane
Control Lysate: A431 Molecular Weight: 160 kDa Human Rectal Carcinoma stained with anti-MSH6 antibody M393
Product Description: MSH6 as a mismatch repair protein is central to mismatch DNA repair. Mutations of MSH6 are found in inherited non polyposis colorectal carcinoma (HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma and cancers of the gastrointestinal, urological and female reproductive tracts.
74
Human Breast Carcinoma stained with anti-mTOR antibody E1859
Product Description: Mammalian target of rapamycin (mTOR) or FKBP12-rapamycin associated protein (FRAP) is a serine/threonine-protein kinase involved in cell cycle progression, DNA recombination, and DNA damage detection. The MTOR-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways. The binding of FRAP to FKBP12-rapamycin is correlated with the ability of these ligands to inhibit cell cycle progression.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies mTOR Rabbit Polyclonal
MUC-1/EMA/Epithelial Membrane Antigen Mouse Monoclonal Clone: N/A
Catalog No.
Size
Format
E11190
0.1ml
Concentrate
Immunogen: Human breast cell line ZR-75-1.
Concentrate
Immunogen: Synthetic peptide derived from human mTOR.
E11192
0.5ml
Concentrate
Concentrate
Application: IHC-P
Application: IHC-P
1.0ml
E11194
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E11191
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E18450
0.1ml
Concentrate
E18452
0.5ml
E18454 E18451
Isotype: Rabbit IgG
Clone: SPM492
Isotype: Mouse IgG1/k Control Tissue: Breast Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm, Membrane
Human Breast Carcinoma stained with anti-mTOR antibody E1845
Human Breast Carcinoma stained with anti-MUC-1/EMA/Epithelial Membrane Antigen antibody E1119
Product Description: Mammalian target of rapamycin (mTOR) or FKBP12-rapamycin associated protein (FRAP) is a serine/threonine-protein kinase involved in cell cycle progression, DNA recombination, and DNA damage detection. The MTOR-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways. The binding of FRAP to FKBP12-rapamycin is correlated with the ability of these ligands to inhibit cell cycle progression.
Product Description: MUC-1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC-1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
MUC-1 Underglycosylated Mouse Monoclonal
Mucin 5AC Mouse Monoclonal
Clone: SPM493
Catalog No.
Size
Format
Concentrate
Immunogen: Human breast cell line ZR-75-1.
E11080
0.1ml
Concentrate
Concentrate
Application: IHC-P, WB
E11082
0.5ml
Concentrate
Immunogen: M1 mucin preparation from the fluid of an ovarian mucinous cyst.
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
Ready-to-Use
Species Reactivity: Human*
E11084
7.0ml
E11081
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E11200
0.1ml
E11202
0.5ml
E11204 E11201
Isotype: Mouse IgG1/k
Clone: 45M1
Species Reactivity: Human*
Control Tissue: Breast Carcinoma
Isotype: Mouse IgG1/k
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm, Membrane
Control Tissue: Stomach
Control Lysate: MCF7 Molecular Weight: 230 kDa Human Breast Carcinoma stained with anti-MUC-1 Underglycosylated antibody E1120
Product Description: Epithelial membrane antigen (EMA), or CA15-3, or polymorphic epithelial mucin (PEM), or sialomucin, or episialin, is a mucin-like glycoprotein. This antibody stains an underglycosylated MUC1 often present on carcinoma cells.
MUC-1/EMA/Epithelial Membrane Antigen Rabbit Polyclonal
Human Stomach stained with anti-Mucin 5AC antibody E1108
Product Description: Mucins are high molecular weight glycoproteins with 80% carbohydrate contents and the remaining 20% is constituted by protein core. Gastric mucin is found in normal human gastrointestinal tract. Resurgence of gastric mucin reactivity during colonic carcinogenesis is due to re-expression of the peptide core of gastric (or fetal colonic) mucins.
Clone: N/A
Mucin 5AC Mouse Monoclonal Catalog No.
Size Format
Clone: SPM488
Concentrate
Immunogen: Synthetic peptide from the cytoplasmic tail of human MUC-1.
E11070
0.1ml
Concentrate
Concentrate
Application: IHC-P
Immunogen: Recombinant Mucin 5AC protein.
1.0ml
E11072
0.5ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
Application: IHC-P
E11074
1.0ml
Concentrate
Isotype: Rabbit IgG
E11071
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E3540
0.1ml
Concentrate
E3542
0.5ml
E3544 E3541
Control Tissue: Breast Carcinoma
Control Tissue: Stomach
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm, Membrane
Human Breast Carcinoma stained with anti-MUC-1/EMA/Epithelial Membrane Antigen antibody E354
Product Description: MUC-1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC-1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
Isotype: Mouse IgG1/k
Human Stomach stained with anti-Mucin 5AC antibody E1107
Product Description: Mucins are high molecular weight glycoproteins with 80% carbohydrate contents and the remaining 20% is constituted by protein core. Gastric mucin is found in normal human gastrointestinal tract. Resurgence of gastric mucin reactivity during colonic carcinogenesis is due to re-expression of the peptide core of gastric (or fetal colonic) mucins.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
75
Mucin-2/MUC-2 Mouse Monoclonal
Myeloperoxidase (MPO) Rabbit Monoclonal
Clone: SPM512
Catalog No.
Size
Format
M3720
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to a site on the MUC-2 glycoprotein.
M3722
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human myeloperoxidase protein.
1.0ml
Concentrate
Application: IHC-P
M3724
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3721
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16560
0.1ml
Concentrate
E16562
0.5ml
E16564 E16561
Clone: SP72
Species Reactivity: Human*
Isotype: Mouse IgG1
Isotype: Rabbit IgG
Control Tissue: Small Intestine
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm
Human Small Intestine stained with anti-Mucin-2/MUC-2 antibody E1656
Human Tonsil stained with anti-Myeloperoxidase (MPO) antibody M372
Product Description: Secreted epithelial mucins are large macromolecules which exhibit extreme polydispersity. Mucin-2 is the major intestinal mucin. O-glycans are attached to MUC-2 in a potentially diverse arrangement, which is crucial for their interaction with endogeneous and exogeneous lectins.
Product Description: Myeloperoxidase (MPO) is an important enzyme used by granulocytes during phagocytic lysis. In normal tissues and in a variety of myeloproliferative disorders myeloid cells of both neutrophilic and eosinophilic types exhibit strong cytoplasmic reactivity for MPO. Erythroid precursors, megakaryocytes, lymphoid cells, mast cells, and plasma cells are nonreactive. MPO is postive in myeloid, but negative in lymphoid leukemias.
MUM1/IRF4 Rabbit Monoclonal
Myeloperoxidase (MPO) Rabbit Polyclonal
Clone: SP114
Catalog No.
Size
Format
E17710
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide near C-terminus of human MUM1/IRF4.
E17712
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human myeloperoxidase protein.
1.0ml
Concentrate
Application: IHC-P, WB
E17714
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E17711
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4140
0.1ml
Concentrate
M4142
0.5ml
M4144 M4141
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Hodgkin’s Lymphoma
Control Tissue: Lymph Node, Spleen, Tonsil
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm
Control Lysate: Ramos Molecular Weight: ~51.7 kDa Human Hodgkin’s Lymphoma stained with anti-MUM1/IRF4 antibody M414
Human Lymph Node stained with anti-Myeloperoxidase (MPO) antibody E1771
Product Description: The MUM1 (Multiple Myeloma Oncogene 1) gene was originally identified because of its involvement in the t(6;14) translocation observed in multiple myeloma, which causes juxtaposition of the MUM1 gene to the Ig heavy-chain locus. MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and extra-hematopoitic tumors. It is an excellent marker for Reed-Sternberg cells of classic Hodgkin’s disease.
Product Description: Myeloperoxidase (MPO) is an important enzyme used by granulocytes during phagocytic lysis. In normal tissues and in a variety of myeloproliferative disorders myeloid cells of both neutrophilic and eosinophilic types exhibit strong cytoplasmic reactivity for MPO. Erythroid precursors, megakaryocytes, lymphoid cells, mast cells, and plasma cells are nonreactive. MPO is postive in myeloid, but negative in lymphoid leukemias.
MUM1/IRF4 Rabbit Polyclonal
Myoglobin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2990
0.1ml
Concentrate
Immunogen: Purified human myoglobin.
Concentrate
Immunogen: Recombinant protein encoding aa 144451 of human MUM1 protein.
E2992
0.5ml
Concentrate
Concentrate
Application: IHC-P
Application: IHC-P, WB
1.0ml
E2994
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2991
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E18350
0.1ml
Concentrate
E18352
0.5ml
E18354 E18351
Isotype: Rabbit IgG Control Tissue: Hodgkin’s Lymphoma Cellular Localization: Cytoplasm, Nucleus
Clone: N/A
Isotype: Rabbit IgG Control Tissue: Skeletal Muscle Cellular Localization: Cytoplasm Control Lysate: Human Skeletal Muscle Molecular Weight: 17 kDa
Human Hodgkin’s Lymphoma stained with anti-MUM1/IRF4 antibody E1835
Product Description: The MUM1 (Multiple Myeloma Oncogene 1) gene was originally identified because of its involvement in the t(6;14) translocation observed in multiple myeloma, which causes juxtaposition of the MUM1 gene to the Ig heavy-chain locus. MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and extra-hematopoitic tumors. MUM1 is a valuable marker for understanding and characterizing histogenesis of B-cell lymphomas.
76
Human Skeletal Muscle stained with anti-Myoglobin antibody E299
Product Description: Myoglobin is a cytoplasmic, single chain polypeptide of 153 amino acids and contains a single heme group. Myoglobin is found in skeletal and cardiac muscle but not in smooth muscle and functions as an oxygen transporting pigment. Upon damage to the muscle cell due to infarction of a coronary artery, neurological trauma, infection of tumor processes, myoglobin escapes to the environment.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies NCK2 Rabbit Polyclonal
Nestin Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18750
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 119-276 of human NCK2.
E18752
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human nestin protein.
1.0ml
Concentrate
Application: IHC-P
E18754
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18751
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E11040
0.1ml
Concentrate
E11042
0.5ml
E11044 E11041
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Tonsil
Control Tissue: Liver Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Breast Carcinoma stained with anti-NCK2 antibody E1104
Human Liver Carcinoma stained with anti-Nestin antibody E1875
Product Description: The NCK family of SH2/SH3 adaptor proteins consists of two members, NCK1 and NCK2, which couple tyrosine kinase signaling, including the EGF and PDGF receptor-pathways, to downstream signaling proteins. The NCK2 protein binds human PDGFR-b (Tyr-1009); overexpression of NCK2 inhibits PDGF-induced membrane ruffling and lamellipod formation.
Product Description: Nestin is a class VI intermediate filament expressed in the developing central nervous system (CNS) in early embryonic neuroepithelial stem cells. This protein has been widely used as a predominant marker for stem / progenitor cells, glioma cells, and tumor endothelial cells in the mammalian CNS. Furthermore, it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumor.
Nephrin Rabbit Polyclonal
Nestin Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18610
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human nephrin.
E18612
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human nestin protein.
1.0ml
Concentrate
Application: IHC-P
E18614
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18611
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18160
0.1ml
Concentrate
E18162
0.5ml
E18164 E18161
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Kidney
Control Tissue: Kidney, Liver Carcinoma
Cellular Localization: Membrane
Cellular Localization: Cytoplasm
Human Kidney stained with anti-Nephrin antibody E1816
Human Liver Carcinoma stained with anti-Nestin antibody E1861
Product Description: Nephrin, a cell adhesion molecule, may play a crucial role in maintaining the glomerular filtration barrier. Three novel podocyte proteins, podocin, nephrin and alpha actinin 4 have been identified. The role of nephrin in anti-apoptotic activity in podocyte is believed to be associated with vascular endothelial derived growth factors VEGF signaling. Nephrin seems to play a role in the development or function of the kidney glomerular filtration barrier.
Product Description: Nestin is a class VI intermediate filament expressed in the developing central nervous system (CNS) in early embryonic neuroepithelial stem cells. This protein has been widely used as a predominant marker for stem / progenitor cells, glioma cells, and tumor endothelial cells in the mammalian CNS. Furthermore, it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumor.
Nestin Rabbit Monoclonal
Neuron Specific Enolase (NSE) Rabbit Polyclonal
Catalog No.
Size
Format
M4030
0.1ml
Concentrate
M4032
0.5ml
Concentrate
M4034
1.0ml
Concentrate
M4031
7.0ml
Ready-to-Use
Clone: SP103
Catalog No.
Size Format
Clone: N/A
Immunogen: Synthetic peptide corresponding to C-terminus of human nestin.
E3300
0.1ml
Concentrate
E3302
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human NSE.
E3304
1.0ml
Concentrate
Application: IHC-P, WB
Application: IHC-P
E3301
7.0ml
Ready-to-Use
Species Reactivity: Human*
Species Reactivity: Human*, Mouse*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Pancreas
Control Tissue: Kidney
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm Control Lysate: HeLa Molecular Weight: 230 kDa Human Kidney stained with anti-Nestin antibody M403
Product Description: Nestin is a class VI intermediate filament expressed in the developing central nervous system (CNS) in early embryonic neuroepithelial stem cells. This protein has been widely used as a predominant marker for stem / progenitor cells, glioma cells, and tumor endothelial cells in the mammalian CNS. Furthermore, it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumor.
Human Pancreas stained with anti-Neuron Specific Enolase (NSE) antibody E330
Product Description: Enolase is a glycolytic enzyme catalyzing the reaction pathway between 2-phospho-glycerate and phosphoenol pyruvate. In mammals, enolase molecules are dimers composed of three distinct subunits (α,β and γ). The alpha-subunit is expressed in most tissues and the beta-subunit only in muscle. The gamma-subunit is expressed primarily in neurons, in normal and in neoplastic neuroendocrine cells. Coexpression of NSE and chromogranin A is common in neuroendocrine neoplasms.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
77
NFkB p50 Rabbit Polyclonal
Nitric Oxide Synthase-Inducible (iNOS) Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M4260
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from N-terminus of human NFκB p50.
M4262
0.5ml
Concentrate
Immunogen: Synthetic peptide near the C-terminus of mouse iNOS protein.
1.0ml
Concentrate
Application: IHC-P
M4264
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M4261
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3630
0.1ml
Concentrate
E3632
0.5ml
E3634 E3631
Clone: SP126
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate, Testis, Tonsil
Control Tissue: Lung
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Tonsil stained with anti-NFkB p50 antibody E363
Human Lung stained with anti-Nitric Oxide Synthase-Inducible (iNOS) antibody M426
Product Description: NF kappa B is a heterodimer consisting of a DNA binding subunit and a transactivating subunit (RelA). P50 subunit of NFkB has an isoform and two proteins of 105 and 100kDa respectively. The p50/p65 heterodimer is present in the cytoplasm in active form bound to its inhibitor, IkB. Upon stimulation of cells with stimuli like LPS, IL-1, IkB gets phosphorylated and degraded by proteosomes releasing the activated NFkB which goes to the nucleus inducing gene expression.
Product Description: Inducible NOS (iNOS) or macrophage NOS (mNOS) is calcium/ calmodulin independent and is expressed in activated macrophages and stimulated glial cells. NOS oxidizes a guanidine nitrogen of arginine, releasing nitric oxide in the form of a free radical and citrulline. Nitric oxide thus generated acts as a messenger in diverse functions including vasodilation, neurotransmission, anti-tumor and anti-pathogenic activities.
NFkB p65 Rabbit Polyclonal
Nitric Oxide Synthase-Inducible (iNOS) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E3740
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal domain of human NFκB p65.
E3742
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of mouse i-NOS.
1.0ml
Concentrate
Application: IHC-P
E3744
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3741
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2750
0.1ml
Concentrate
E2752
0.5ml
E2754 E2751
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta, Prostate
Control Tissue: Lung
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Cytoplasm
Human Prostate stained with anti-NFkB p65 antibody E275
Human Lung stained with anti-Nitric Oxide Synthase-Inducible (iNOS) antibody E374
Product Description: NF kappa B is a heterodimer consisting of a 50kDa DNA binding subunit and a 65kDa transactivating subunit (RelA). The p50/p65 heterodimer is present in the cytoplasm in inactive form bound to its inhibitor, IκB. In unstimulated cells, nuclear localization signals present on p65 are masked by members of the IκB family of inhibitory proteins. Subsequent to cell stimulation, IκB undergoes phosphorylation, ubiquitination and degradation by a proteosome-dependent pathway.
Product Description: NOS oxidizes a guanidine nitrogen of arginine releasing nitric oxide in the form of a free radical and citrulline. Nitric oxide thus generated acts as a messenger in diverse functions including vasodilation neurotransmission, anti-tumor and anti-pathogenic activities. Inducible NOS (iNOS) or macrophage NOS (mNOS) is calcium/calmodulin independent and is expressed in activated macrophages and stimulated glial cells. This antibody reacts with iNOS.
Nitric Oxide Synthase-Endothelial (eNOS) Rabbit Polyclonal
Nitric Oxide Synthase-Universal (uNOS) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3930
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human e-NOS.
E3932
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of mouse iNOS and nNOS.
1.0ml
Concentrate
Application: IHC-P
E3934
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3931
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4110
0.1ml
Concentrate
E4112
0.5ml
E4114 E4111
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta
Control Tissue: Placenta
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Placenta stained with anti-Nitric Oxide Synthase-Endothelial (eNOS) antibody E411
Human Placenta stained with anti-Nitric Oxide Synthase-Universal (uNOS) antibody E393
Product Description: NOS oxidizes a guanidine nitrogen of arginine releasing nitric oxide in the form of a free radical and citrulline. Nitric oxide thus generated acts as a messenger in diverse functions including vasodilation neurotransmission, anti-tumor and anti-pathogenic activities. NOS is classified under three types: neuronal NOS (nNOS) or brain NOS (bNOS); inducible NOS (iNOS) or macrophage NOS (mNOS); and endothelial NOS (eNOS). This antibody reacts with eNOS.
78
Clone: N/A
Product Description: NOS oxidizes a guanidine nitrogen of arginine releasing nitric oxide in the form of a free radical and citrulline. Nitric oxide thus generated, acts as a messenger in diverse functions including vasodilation neurotransmission, anti-tumor and anti-pathogenic activities. NOS is classified under three types: neuronal NOS (nNOS) or brain NOS (bNOS); inducible NOS (iNOS) or macrophage NOS (mNOS); and endothelial NOS (eNOS). This antibody reacts with iNOS, bNOS and eNOS.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies NKX3.1 Rabbit Polyclonal
Occludin Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E17460
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human NKX3.1
E17462
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E17464
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E17461
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E14100
0.1ml
Concentrate
E14102
0.5ml
E14104 E14101
Clone: N/A Immunogen: Synthetic peptide corresponding to C-terminus of human occludin. Application: IHC-P, WB Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate, Prostate Carcinoma
Control Tissue: Lung
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Membrane Control Lysate: Human Kidney Molecular Weight: 65 kDa
Human Prostate stained with anti-NKX3.1 antibody E1410
Human Lung stained with anti-Occludin antibody E1746
Product Description: The NKX3.1 gene is an androgen regulated prostate-specific homeobox gene, located on chromosome 8p21. In mice, the homologue NKX3.1 is exclusively expressed in prostate epithelium. In humans, NKX3.1 expression is also restricted to the prostate. Many data show that NKX3.1 expression is highly, but not exclusively, specific for the prostate.
Product Description: Occludin can exist in a variety of phosphorylated forms, ranging up to approximately 82kDa. This phosphorylation is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression. The level of occludin varies. In brain tissue, occludin is highly expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution.
Notch-1 Rabbit Polyclonal
OCT-1 Rabbit Polyclonal Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E3840
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human notch-1.
E3842
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human OCT-1.
1.0ml
Concentrate
Application: IHC-P
E3844
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3841
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10860
0.1ml
Concentrate
E10862
0.5ml
E10864 E10861
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Ovarian Carcinoma
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Nucleus
Human Ovarian Carcinoma stained with anti-Notch-1 antibody E1086
Human Tonsil stained with anti-OCT-1 antibody E384
Product Description: The 280-330kDa Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for notch include Jagged, Jagged-2 and delta. Jagged can activate notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes.
Product Description: The POU dimer from the OCT-1 gene formed on the palindromic OCT factor recognition element, or PORE (ATTTGAAATGCAAAT), could recruit the transcriptional coactivator OBF1. OCT-1 encodes one protein, NF-A1, which is found in nuclear extracts from all cell types and thus is not specific to lymphoid cells as is the protein NF-A2, which is encoded by OCT-2. The OCT-1 and OCT-2 map to human chromosomes 1q22-q23 and 19, respectively.
NRF2 Rabbit Polyclonal
OCT-2 Rabbit Polyclonal Clone: N/A
Catalog No.
Size Format
Clone: N/A
E4300
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human NRF2 protein.
E4302
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human OCT-2.
1.0ml
Concentrate
Application: IHC-P
E4304
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4301
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E12500
0.1ml
Concentrate
E12502
0.5ml
E12504 E12501
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta, Lung
Control Tissue: Tonsil
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Nucleus
Human Placenta stained with anti-NRF2 antibody E1250
Human Tonsil stained with anti-OCT-2 antibody E430
Product Description: NRF1 (also designated TCF11), NRF2 and NRF3 are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE (Maf recognition elements) sequences. NRF2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1.
Product Description: OCT-2 is a transcription factor belonging to the POU homeodomain family that binds to the Ig gene octomer sites regulating B cell specific genes. OCT-2 protein expression is not restricted to B cells, although expression levels are much higher in these cells. OCT-2 expression is reported to be significantly greater in germinal center derived lymphomas, although other B cell lymphomas also display high levels of expression.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
79
OCT-3/OCT-4 Rabbit Polyclonal
p120 (catenin delta 1) Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3630
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human OCT-3/OCT-4 protein.
M3632
0.5ml
Concentrate
Immunogen: Synthetic peptide from C-terminus of human p120.
1.0ml
Concentrate
Application: IHC-P
M3634
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3631
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18280
0.1ml
Concentrate
E18282
0.5ml
E18284 E18281
Clone: SP63
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Seminoma
Control Tissue: Breast Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm, Membrane
Human Seminoma stained with anti-OCT-3/OCT-4 antibody E1828
Human Breast Carcinoma stained with anti-p120 (catenin delta 1) antibody M363
Product Description: OCT-3 (also known as OCT-4) is a mammalian POU transcription factor expressed by early embryo cells and germ cells. OCT-3/4 is essential for the identity of the pluripotential founder cell population in the mammalian embryo. A critical amount of OCT-3/4 is required to sustain stem cell renewal, and up or down regulation induce divergent developmental programs.
Product Description: Catenin delta 1 (p120) is an efficient tyrosine kinase substrate implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for the cell-adhesion properties of cadherins.
OCT-3/OCT-4 Rabbit Polyclonal
p120 (catenin delta 1) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17530
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human OCT-3/OCT-4 protein.
E17532
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human p120.
1.0ml
Concentrate
Application: IHC-P
E17534
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E17531
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17720
0.1ml
Concentrate
E17722
0.5ml
E17724 E17721
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Seminoma
Control Tissue: Breast Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm, Membrane
Human Seminoma stained with anti-OCT-3/OCT-4 antibody E1772
Human Breast Carcinoma stained with anti-p120 (catenin delta 1) antibody E1753
Product Description: OCT-3 (also known as OCT-4) is a mammalian POU transcription factor expressed by early embryo cells and germ cells. OCT-3/4 is essential for the identity of the pluripotential founder cell population in the mammalian embryo. A critical amount of OCT-3/4 is required to sustain stem cell renewal, and up or down regulation induce divergent developmental programs.
Product Description: Catenin delta 1 (p120) is an efficient tyrosine kinase substrate implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for the cell-adhesion properties of cadherins.
Osteopontin Rabbit Polyclonal
p14ARF Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4350
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal domain of human osteopontin.
E4352
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human p14ARF.
1.0ml
Concentrate
Application: IHC-P
E4354
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4351
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3280
0.1ml
Concentrate
E3282
0.5ml
E3284 E3281
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Lymphoma
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus
Human Breast Carcinoma stained with anti-Osteopontin antibody E328
Human Lymphoma stained with anti-p14ARF antibody E435
Product Description: Osteopontin is a 34kDa extracellular matrix protein with a cell binding domain. It was originally identified as a major component of the noncollagenous organic bone matrix, however, it has subsequently been demonstrated in a wide range of normal adult tissue and body fluids. It is involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation.
80
Clone: N/A
Product Description: The INK4a-ARF locus encodes two unrelated proteins both of which function in tumor suppression. p14ARF binds to mdm2 and promotes the rapid degradation of mdm2 protein required for mdm2 modification and concurrent p53 stabilization and accumulation. This interaction is mediated by the exon 1beta-encoded N-terminal domain of p14ARF and a C-terminus region of mdm2.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies p27Kip1 Rabbit Polyclonal
p53 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2010
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human p27Kip1.
E2012
0.5ml
Concentrate
Immunogen: Recombinant human full length wild type p53 protein.
1.0ml
Concentrate
Application: IHC-P
E2014
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2011
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2600
0.1ml
Concentrate
E2602
0.5ml
E2604 E2601
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Prostate
Control Tissue: Colon Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Prostate stained with anti-p27Kip1 antibody E260
Human Colon Carcinoma stained with anti-p53 antibody E201
Product Description: This antibody recognizes a protein of 27kDa, identified as p27Kip1. p27Kip1 is a candidate tumor suppressor gene and functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF-b induced G1 arrest.
Product Description: p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein. p53 senses DNA damage and possibly facilitates repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
p300/CBP Rabbit Polyclonal
p53 Mouse Monoclonal Clone: N/A
Catalog No.
Size
Format
E16570
0.1ml
Concentrate
Immunogen: Recombinant human p53 protein.
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human p300.
E16572
0.5ml
Concentrate
Concentrate
Application: IHC-P
Application: IHC-P
1.0ml
E16574
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E16571
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E14070
0.1ml
Concentrate
E14072
0.5ml
E14074 E14071
Isotype: Rabbit IgG
Clone: SPM514
Isotype: Mouse IgG2a/k Control Tissue: Colon Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Breast Carcinoma stained with anti-p300/CBP antibody E1407
Human Colon Carcinoma stained with anti-p53 antibody E1657
Product Description: The p300-CBP is composed of two transcriptional co-activating proteins with similar structures: p300 and CBP. Both p300 and CBP interact with numerous transcription factors and act to increase the expression of their target genes such as cAMP-regulated enhancer (CRE). Both contain five protein interaction domains: the nuclear receptor interaction domain, the CREB-MYB interaction domain, the cysteine/histidine regions and the interferon binding domain.
Product Description: p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein. p53 senses DNA damage and possibly facilitates repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
p53 Rabbit Monoclonal
p57** Rabbit Monoclonal Clone: SP5
Catalog No.
Size Format
Clone: SP118
M4180
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant human full length wild type p53 protein.
M4182
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to an internal region of human p57 protein.
1.0ml
Concentrate
Application: IHC-P
M4184
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M4181
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
M3050
0.1ml
Concentrate
M3052
0.5ml
M3054 M3051
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma
Control Tissue: Placenta
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Colon Carcinoma stained with anti-p53 antibody M305
Human Placenta stained with anti-p57 antibody M418
Product Description: p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein. p53 senses DNA damage and possibly facilitates repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Product Description: Cyclin-dependent kinase inhibitor 1C (CDKN 1C or p57/Kip2) is a nuclear protein and a potent inhibitor for several G1 cyclin/Cdk complexes. P57 inhibits cell proliferation and the mutation of p57 gene can lead to uncontrollable cell growth and malignancy such as hydatidiform mole.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
81
p57 Rabbit Polyclonal
p70S6k (Phospho T421/S424) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18500
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human p57/kip2 protein.
E18502
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E18504
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18501
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18990
0.1ml
Concentrate
E18992
0.5ml
E18994 E18991
Clone: N/A Immunogen: Synthetic peptide derived from the region of human p70S6K that contains phosphorylated threonine 421 and serine 424. Application: IHC-P Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Hydatid Mole, Placenta Cellular Localization: Nucleus
Control Tissue: Alzheimer’s Brain, Breast Carcinoma
Human Hydatid Mole stained with anti-p57 antibody E1899
Human Alzheimer’s Brain stained with anti-p70S6k (Phospho T421/S424) antibody E1850
Cellular Localization: Cytoplasm
Product Description: p57/Kip 2 (or CDKN 1C) is a potent tight binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57/Kip 2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm’s tumor, and Beckwith Wiedemann syndrome (BWS, a cancer syndrome) making p57/Kip 2 a tumor suppressor candidate.
Product Description: Ribosomal S6 kinase has two isoforms, termed S6K1 (S6Ka) and S6K2 (S6Kb). The S6K1 isoform has two splicing forms: p70S6K or p70S6K1 with a molecular mass of 70kDa and the second isoform, p85S6K or p85S6K1 with a molecular mass of 85kDa. Both p70 and p85 S6K1 are activated by multiple S/T phosphorylations in response to various mitogenic stimuli and nutrients. This antibody detects p70S6K only when phosphorylated at T421/S424.
p70S6k Rabbit Polyclonal
PAK alpha Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E12550
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human p70S6k protein.
E12552
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to aa 525-545 of rat PAK alpha.
1.0ml
Concentrate
Application: IHC-P
E12554
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E12551
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18640
0.1ml
Concentrate
E18642
0.5ml
E18644 E18641
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Nucleus
Human Breast Carcinoma stained with anti-p70S6k antibody E1864
Human Breast Carcinoma stained with anti-PAK alpha antibody E1255
Product Description: Ribosomal S6 kinase has two isoforms, termed S6K1 (S6Ka) and S6K2 (S6Kb). The S6K1 isoform has two splicing forms: p70S6K or p70S6K1 with a molecular mass of 70kDa and the second isoform, p85S6K or p85S6K1 with a molecular mass of 85kDa. Both, p70 and p85 S6K1 are activated by multiple S/T phosphorylations in response to various mitogenic stimuli and nutrients.
Product Description: Alpha PAK p68, beta PAK p65 and gamma PAK p62 are three isoforms of serine/threonine kinases. These three isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation.
p70S6k (Paired 421/424) Rabbit Polyclonal
Parathyroid Hormone Rabbit Polyclonal
Catalog No.
Size
Format
E18510
0.1ml
Concentrate
E18512
0.5ml
Concentrate
E18514
1.0ml
Concentrate
E18511
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide derived from the region of human p70S6K that contains non-phosphorylated threonine 421 and serine 424.
E18090
0.1ml
Concentrate
E18092
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human parathyroid hormone.
E18094
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
E18091
7.0ml
Ready-to-Use
Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Breast Carcinoma Cellular Localization: Cytoplasm
Human Breast Carcinoma stained with anti-p70S6k (Paired 421/424) antibody E1851
Product Description: Ribosomal S6 kinase has two isoforms, termed S6K1 (S6Ka) and S6K2 (S6Kb). The S6K1 isoform has two splicing forms: p70S6K or p70S6K1 with a molecular mass of 70kDa and the second isoform, p85S6K or p85S6K1 with a molecular mass of 85kDa. Both p70 and p85 S6K1 are activated by multiple S/T phosphorylations in response to various mitogenic stimuli and nutrients. This antibody detects p70S6K that is non-phosphorylated at T421/S424.
82
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Parathyroid Gland Cellular Localization: Cytoplasm
Human Parathyroid Gland stained with anti-Parathyroid Hormone antibody E1809
Product Description: Parathyroid hormone (PTH) is secreted by parathyroid cells. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism. Most PTH is secreted in its intact, mature 9.5kDa form, amino acids 1-84; however, it can also be secreted as N-terminal truncated fragments or C-terminus fragments after intracellular degradation, as in case of hypercalcemia.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Parathyroid Hormone Receptor 1 Rabbit Polyclonal Catalog No.
Size
Format
E17890
0.1ml
Concentrate
E17892
0.5ml
Concentrate
E17894
1.0ml
Concentrate
E17891
7.0ml
Ready-to-Use
PAX-5 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to N-terminus of human parathyroid hormone receptor type 1.
E4390
0.1ml
Concentrate
E4392
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human PAX-5 protein.
E4394
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
E4391
7.0ml
Ready-to-Use
Species Reactivity: Human*
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Parathyroid Gland
Cellular Localization: Nucleus
Cellular Localization: Membrane
Human Parathyroid Gland stained with anti-Parathyroid Hormone Receptor 1 antibody E1789
Human Tonsil stained with anti-PAX-5 antibody E439
Product Description: Two human parathyroid hormone (hPTH) receptors are known: one that binds both hPTH and a PTH-related protein called PTHrP (the Type I receptor); and one that only binds hPTH (the Type II receptor).
Product Description: PAX-5 is a B cell specific activator protein. In the early stages of B cell development, PAX-5 influences the expression of several B cell specific genes, such as CD19 and CD20. PAX-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. PAX-5 mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis and then shifts to the fetal liver. This indicates that PAX-5 is important in B cell and neuronal development.
Parkin Rabbit Polyclonal
Paxillin Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E13870
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human parkin protein.
E13872
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 356-558 of human paxillin.
1.0ml
Concentrate
Application: IHC-P
E13874
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E13871
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3470
0.1ml
Concentrate
E3472
0.5ml
E3474 E3471
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Alzheimer’s Brain
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Alzheimer’s Brain stained with anti-Parkin antibody E347
Human Breast Carcinoma stained with anti-Paxillin antibody E1387
Product Description: Parkin has been mapped to chromosome 6 and encodes a protein of 465 amino acids with similarity to ubiquitin at the amino terminus and a RINGfinger motif at the carboxyl terminus. Parkinson’s disease is the second most common neurodegenerative disease following Alzheimer’s. The characteristic movement disorder results from dysfunction and neuron loss in the substantia nigra. Deletions in Parkin have been associated with autosomal-recessive juvenile parkinsonism.
Product Description: Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as SRC, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and CRK through its SH2 domain. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
PAX-5 Rabbit Monoclonal
PCNA Rabbit Polyclonal Clone: SP34
Catalog No.
Size Format
Clone: N/A
E2850
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human PAX-5 protein.
E2852
0.5ml
Concentrate
Immunogen: Recombinant human PCNA protein.
1.0ml
Concentrate
Application: IHC-P
E2854
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2851
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
M3340
0.1ml
Concentrate
M3342
0.5ml
M3344 M3341
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Small Intestine, Tonsil
Cellular Localization: Nucleus
Cellular Localization: Nucleus Control Lysate: 293T Molecular Weight: 30 kDa
Human Tonsil stained with anti-PAX-5 antibody M334
Product Description: PAX-5 is a B cell specific activator protein. In the early stages of B cell development, PAX-5 influences the expression of several B cell specific genes, such as CD19 and CD20. PAX-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. PAX-5 mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis and then shifts to the fetal liver. This indicates that PAX-5 is important in B cell and neuronal development.
Human Tonsil stained with anti-PCNA antibody E285
Product Description: Expression of proliferating cell nuclear antigen (PCNA) or cyclin or polymerase delta auxiliary protein is elevated in the nucleus during late G1 phase immediately before the onset of DNA synthesis, becoming maximal during S-phase and declining during G2 and M phases. PCNA/cyclin may act as an auxiliary protein of DNA polymerase-delta to play a fundamental role in the initiation of cell proliferation.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
83
PD-1/CD279 Rabbit Polyclonal
PDGFR alpha Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2690
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from near N-terminus of human CD279 protein.
E2692
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human PDGFR alpha.
1.0ml
Concentrate
Application: IHC-P
E2694
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2691
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18660
0.1ml
Concentrate
E18662
0.5ml
E18664 E18661
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Kidney, Ovarian Carcinoma, Skin
Cellular Localization: Membrane
Cellular Localization: Cytoplasm, Membrane
Human Tonsil stained with anti-PD-1/CD279 antibody E1866
Human Ovarian Carcinoma stained with anti-PDGFR alpha antibody E269
Product Description: CD279, also known as Programmed Cell Death 1 (PD-1), is an immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8 thymocytes, and on activated T and B cells. It is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PDL1 (also known as B7H1) and PDL2 (B7DC), are members of the B7 immunoglobulin superfamily.
Product Description: PDGFR (Platelet Derived Growth Factor Receptor) exhibits two different isoforms, alpha and beta, coded by two different genes. PDGF alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are expressed on neurons. This antibody is specific for PDGFR alpha and does not react with PDGFR beta.
PD-1/CD279 Rabbit Polyclonal
PDGFR beta Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2730
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human PD-1/CD279 protein.
E2732
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human PDGFR beta.
1.0ml
Concentrate
Application: IHC-P
E2734
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2731
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18630
0.1ml
Concentrate
E18632
0.5ml
E18634 E18631
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lymph Node, Tonsil
Control Tissue: Kidney, Ovarian Carcinoma, Skin
Cellular Localization: Membrane
Cellular Localization: Cytoplasm, Membrane
Human Lymph Node stained with anti-PD-1/CD279 antibody E1863
Human Ovarian Carcinoma stained with anti-PDGFR beta antibody E273
Product Description: CD279, also known as Programmed Cell Death 1 (PD-1), is an immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8 thymocytes, and on activated T and B cells. It is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PDL1 (also known as B7H1) and PDL2 (B7DC), are members of the B7 immunoglobulin superfamily.
Product Description: PDGFR (Platelet Derived Growth Factor Receptor) exhibits two different isoforms, alpha and beta, coded by two different genes. PDGF alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are expressed on neurons. This antibody is specific for PDGFR beta and does not react with PDGFR alpha.
PDCD6 Rabbit Polyclonal
PDK-1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18410
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human PDCD6 protein.
E18412
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from the human PDK-1.
1.0ml
Concentrate
Application: IHC-P
E18414
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18411
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17690
0.1ml
Concentrate
E17692
0.5ml
E17694 E17691
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm
Human Lung Carcinoma stained with anti-PDCD6 antibody E1769
Human Breast Carcinoma stained with anti-PDK-1 antibody E1841
Product Description: This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.
84
Clone: N/A
Product Description: Phosphoinositide-dependent protein kinase 1 (PDK1) plays a central role in many signal transduction pathways, including the activation of Akt and PKC isoenzyme p70S6 kinase and RSK. Through its effects on these kinases, PDK1 is involved in the regulation of a wide variety of processes, including cell proliferation, differentiation and apoptosis.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies PDS-1/Securin Rabbit Polyclonal
Phosphotyrosine Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E3080
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human PDS-1 protein.
E3082
0.5ml
Concentrate
Immunogen: Phosphotyrosine conjugated to protein carriers.
1.0ml
Concentrate
Application: IHC-P
E3084
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3081
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18530
0.1ml
Concentrate
E18532
0.5ml
E18534 E18531
Clone: SPM102
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Mouse IgG1
Control Tissue: Rectal Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Cytoplasm, Membrane
Human Rectal Carcinoma stained with anti-PDS-1/Securin antibody E1853
Human Breast Carcinoma stained with anti-Phosphotyrosine antibody E308
Product Description: Securin is an anaphase inhibitor and plays an important role in DNA damage and spindle check point pathways. It is targeted for degradation by ubiquitination mediated by a ubiquitin ligase - anaphase promoting complex (APC). Securin is highly expressed in various human tumors, including pituitary, adrenal, kidney, liver, and ovarian tumors, and in cell lines derived from pituitary tumors, breast tumors, endometrial tumors, and ovarian tumors.
Product Description: Protein phosphorylation is a fundamental event in the regulation of a large number of intracellular processes. This antibody is specific to phosphotyrosine and shows no cross-reaction with other phosphoamino acids.
Peripheral Myelin Protein (PMP-22) Rabbit Polyclonal
PI3K p110beta Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18210
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from near C-terminus of human PMP-22.
E18212
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human PI3k p110beta.
1.0ml
Concentrate
Application: IHC-P
E18214
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18211
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3520
0.1ml
Concentrate
E3522
0.5ml
E3524 E3521
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Pancreas
Control Tissue: Breast Carcinoma, Placenta
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Pancreas stained with anti-Peripheral Myelin Protein (PMP-22) antibody E352
Human Breast Carcinoma stained with anti-PI3K p110beta antibody E1821
Product Description: PMP-22 (Peripheral Myelin Protein) is a glycoprotein expressed in the compact myolin of the peripheral nervous system. In the peripheral nervous system, PMP-22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) and protein P0 during nerve development and regeneration. Alterations in the level of this protein cause several genetic human diseases.
Product Description: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol. The enzyme comprises a 110kDa catalytic subunit and a regulatory subunit of either 85, 55, or 50kDa. The loss of p110 beta decreases tumorigenesis in a mouse cancer model with lipid phosphatase PTEN deficiency. This antibody is specific to PI3K p110beta.
Phospho-Ser/Thr/Tyr Mouse Monoclonal
PI3K p85 Rabbit Monoclonal
Clone: SPM101
Catalog No.
Size
Format
M3620
0.1ml
Concentrate
Concentrate
Immunogen: Phosphoserine, phosphothreonine, and phosphotyrosine conjugated to protein carriers.
M3622
0.5ml
Concentrate
Immunogen: Synthetic peptide from N-terminus of human PI3K p85.
1.0ml
Concentrate
Application: WB
M3624
1.0ml
Concentrate
Application: IHC-P
N/A
N/A
Species Reactivity: Human*
M3621
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3070
0.1ml
Concentrate
E3072
0.5ml
E3074 N/A
Clone: SP62
Species Reactivity: Human*
Isotype: Mouse IgG1
Isotype: Rabbit IgG
Control Tissue: N/A
Control Tissue: Placenta
Cellular Localization: N/A
Cellular Localization: Cytoplasm
Control Lysate: Jurkat Molecular Weight: 20 KDa N/A E307
Product Description: This antibody recognizes serine, threonine, and tyrosine phosphorylated proteins as determined by ELISA using phosphorylated peptides. Reactivity has also been shown with phosphorylated proteins in western blots.
Human Placenta stained with anti-PI3K p85 antibody M362
Product Description: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110kDa catalytic subunit and a regulatory subunit of either 85, 55, or 50kDa. This antibody is specific to PI3K p85 which is a 85kDa regulatory subunit.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
85
PI3K p85 Rabbit Polyclonal
Placental Lactogen (hPL) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2980
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human PI3K p85.
E2982
0.5ml
Concentrate
Immunogen: Purified human placental lactogen.
1.0ml
Concentrate
Application: IHC-P
E2984
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2981
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18200
0.1ml
Concentrate
E18202
0.5ml
E18204 E18201
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Placenta
Control Tissue: Placenta
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm Control Lysate: Human Placenta Molecular Weight: 21 kDa
Human Breast Carcinoma stained with anti-PI3K p85 antibody E1820
Human Placenta stained with anti-Placental Lactogen (hPL) antibody E298
Product Description: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110kDa catalytic subunit and a regulatory subunit of either 85, 55, or 50kDa. This antibody is specific to PI3K p85 which is a 85kDa regulatory subunit.
Product Description: Human placental lactogen (hPL) is known to originate in the syncytiotrophoblasts. Ultrastructural localization indicates that placental lactogen is stored in small morphologically distinct cytoplasmic granules within these cells and has a different secretory mechanism from other hormonal peptides such as human chorionic gonadotropin. The level of expression of placental lactogen through pregnancy increases gradually to term.
PIM-1 Rabbit Polyclonal
PLAP Rabbit Monoclonal Clone: SP15
Clone: N/A
Catalog No.
Size
Format
M3150
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human PIM-1 protein.
M3152
0.5ml
Concentrate
Immunogen: Recombinant protein encoding human placental alkaline phosphatase.
1.0ml
Concentrate
Application: IHC-P
M3154
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3151
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18710
0.1ml
Concentrate
E18712
0.5ml
E18714 E18711
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bone Marrow
Control Tissue: Placenta, Seminoma
Cellular Localization: Cytoplasm, Membrane, Nucleus
Cellular Localization: Cytoplasm, Membrane
Human Bone Marrow stained with anti-PIM-1 antibody E1871
Human Seminoma stained with anti-PLAP antibody M315
Product Description: PIM-1 is a member of the serine/threonine kinase PIM oncogene family. PIM-1 has been implicated in lymphomagenesis, cell proliferation, apoptosis, differentiation and tumourigenesis. The PIM-1 protein kinase is upregulated in prostate cancer.
Product Description: This antibody reacts with a membrane-bound isoenzyme of placental alkaline phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is expressed in testicular germ cell tumors. Unlike germ cell tumors, PLAPpositive somatic cell tumors uniformly express epithelial membrane antigen (EMA).
PIM-2 Rabbit Polyclonal
PLAP Rabbit Polyclonal Catalog No.
Size
Format
E2040
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from near C-terminus of human PIM-2 protein.
E2042
0.5ml
Concentrate
Immunogen: Recombinant protein encoding human placental alkaline phosphatase.
1.0ml
Concentrate
Application: IHC-P
E2044
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2041
7.0ml
Ready-to-Use
Size
Format
E18800
0.1ml
Concentrate
E18802
0.5ml
E18804 E18801
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: B Cell Lymphoma
Control Tissue: Placenta, Seminoma
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Cytoplasm, Membrane
Human B Cell Lymphoma stained with anti-PIM-2 antibody E1880
Human Seminoma stained with anti-PLAP antibody E204
Product Description: PIM-2 belongs to a family of cytoplasmic serine/threonine protein kinases that consists of two other members, PIM-1 and PIM-3. Expression of this protein is regulated by hematopoietic cytokines. PIM-2 is most abundantly expressed in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. PIM-2 is thought to be a mediator of p53 mediated apoptosis inhibition by interleukin 3.
86
Clone: N/A
Clone: N/A
Catalog No.
Product Description: This antibody reacts with a membrane-bound isoenzyme of placental alkaline phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is expressed in testicular germ cell tumors. Unlike germ cell tumors, PLAPpositive somatic cell tumors uniformly express epithelial membrane antigen (EMA).
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies PLC beta 1 Rabbit Polyclonal
PML Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E12400
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human PLC beta 1.
E12402
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to near N-terminus of human PML.
1.0ml
Concentrate
Application: IHC-P
E12404
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E12401
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E14110
0.1ml
Concentrate
E14112
0.5ml
E14114 E14111
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain
Control Tissue: Lymph Node
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Nucleus
Human Brain stained with anti-PLC beta 1 antibody E1411
Human Lymph Node stained with anti-PML antibody E1240
Product Description: Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes such as PLC β1a and PLC β1b. PLC β1a is preferentially expressed in the cytosol, whereas PLC β1b is predominantly localized in the nuclei.
Product Description: The PML protein is a zinc finger transcription factor expressed as three major transcription products due to alternative splicing. The t(15;17) (q22;q11.2-q12) chromosomal translocation of the retinoic acid receptor alpha gene occurs in virtually all cases of acute promyelocytic leukemia. Myeloid precursor cells expression the PML/RAR alpha chimera fail to differentiate and exhibit an increased growth rate consequent to diminished apoptosis.
PLC gamma 2 Rabbit Polyclonal
PMS2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18560
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human PLC gamma 2 protein.
E18562
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human PMS2 protein.
1.0ml
Concentrate
Application: IHC-P
E18564
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18561
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12470
0.1ml
Concentrate
E12472
0.5ml
E12474 E12471
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Hodgkin’s Lymphoma
Control Tissue: Rectal Carcinoma
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Nucleus
Human Hodgkin’s Lymphoma stained with anti-PLC gamma 2 antibody E1247
Human Rectal Carcinoma stained with anti-PMS2 antibody E1856
Product Description: Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5 bisphosphate. There are many mammalian PLC isozymes, including PLC B1, PLC B2, PLC B3, PLCB4, PLCy1, PLCy2, PLC 81, PLC82 and PLCe with molecular weights ranging from 85 to 150kDa.
Product Description: Mismatch DNA repair in bacteria is carried out by the MutL, MutH, and MutS proteins. The MutS protein initially binds to mismatched DNA. This is followed by binding of the MutH endonuclease and MutL to form a complex that carries out excision repair. The hMSH2 gene specifies a MutS homologue whereas hMLH1, hPMS1, and hPMS2 encode MutL homologs. Mutations in these genes are associated with hereditary nonpolyposis colon cancer (HNPCC).
Pleiotrophin Rabbit Polyclonal
Podocin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size Format
Clone: N/A
E18150
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from near N-terminus of human pleiotrophin protein.
E18152
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E18154
1.0ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human podocin.
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18151
7.0ml
Ready-to-Use
Application: IHC-P, WB
Catalog No.
Size
Format
E18820
0.1ml
Concentrate
E18822
0.5ml
E18824 E18821
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain, Colon Carcinoma
Control Tissue: Kidney
Cellular Localization: Cytoplasm
Cellular Localization: Membrane Control Lysate: 293T Molecular Weight: 42/34 kDa
Human Brain stained with anti-Pleiotrophin antibody E1882
Product Description: Pleiotrophin (PTN) is a secreted heparin and chondroitin-binding protein. It is a regulatory cytokine critical to the early development of blood vessels and neurons. High PTN serum levels are associated with a variety of solid tumors such as multiple myeloma (MM). The amount of PTN is correlated with the MM disease status and response to treatment. The expression of this protein is very limited in normal adult tissues.
Human Kidney stained with anti-Podocin antibody E1815
Product Description: Podocin (NPHS2 protein) is an important member of a group of proteins shown to be associated with the slit diaphragm. Podocin belongs to the band 7 stomatin family of lipid raft-associated proteins. Podocin is thought to act as a scaffold protein required to maintain or regulate the structural integrity of the slit diaphragm. It plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
87
Poly ADP-Ribose Polymerase (PARP) Rabbit Polyclonal
Progesterone Receptor (PR) Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3420
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human PARP protein.
M3422
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 412526 of human progesterone receptor.
1.0ml
Concentrate
Application: IHC-P
M3424
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3421
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4220
0.1ml
Concentrate
E4222
0.5ml
E4224 E4221
Clone: SP42
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Breast Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Tonsil stained with anti-Poly ADP-Ribose Polymerase (PARP) antibody E422
Human Breast Carcinoma stained with anti-Progesterone Receptor (PR) antibody M342
Product Description: PARP uses nicotinamide adenine dinucleotide (oxidized form) NAD as a substrate to catalyze the transfer of ADP-ribose to a variety of nuclear protein acceptors. Proteolysis of PARP to its stable 85kDa fragment is an early marker of programmed cell death and is mediated by the caspase CPP32 protein.
Product Description: The progesterone receptor (PR) is an estrogen-regulated protein. It has been proposed that expression of PR determination indicates a responsive estrogen receptor (ER) pathway. A number of studies have shown that PR determination provides supplementary information to ER.
Potassium Channel Kv3.2 Rabbit Polyclonal
Progesterone Receptor (PR) Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3020
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from internal region of rat potassium channel Kv3.2.
M3022
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 412-526 of human progesterone receptor.
1.0ml
Concentrate
Application: IHC-P
M3024
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3021
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10800
0.1ml
Concentrate
E10802
0.5ml
E10804 E10801
Clone: SP2
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus
Human Brain stained with anti-Potassium Channel Kv3.2 antibody E1080
Human Breast Carcinoma stained with anti-Progesterone Receptor (PR) antibody M302
Product Description: Potassium channels contribute to maintaining cell volume, membrane potential, neuronal excitability and the secretion of transmitters, salt and hormones. Two families of potassium channels have been identified. One family includes the inwardly rectifying potassium channels whereas, the other family includes: voltagesensing (KV); big conductance, calcium activated (BKca); and small conductance, calcium activated (SK) potassium channels.
Product Description: The progesterone receptor (PR) is an estrogen-regulated protein. It has been proposed that expression of PR determination indicates a responsive estrogen receptor (ER) pathway. A number of studies have shown that PR determination provides supplementary information to ER.
Presenilin Rabbit Polyclonal
Progesterone Receptor (PR) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2070
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human presenilin 1 protein.
E2072
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human PgR.
1.0ml
Concentrate
Application: IHC-P
E2074
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2071
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3480
0.1ml
Concentrate
E3482
0.5ml
E3484 E3481
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Nucleus
Human Brain stained with anti-Presenilin antibody E348
Human Breast Carcinoma stained with anti-Progesterone Receptor (PR) antibody E207
Product Description: In addition to β-amyloid precursor protein (β-APP), three other gene products have been implicated in Familial Alzheimer’s Disease (FAD): presenilin 1 (PS-1), presenilin 2 (PS-2), and apolipoprotein E (apoE4). Mutations in the genes encoding β-APP, PS-1, and PS-2 are believed to contribute to presenile FAD.
88
Clone: N/A
Product Description: The progesterone receptor (PR) is an estrogen-regulated protein. It has been proposed that expression of PR determination indicates a responsive estrogen receptor (ER) pathway. A number of studies have shown that PR determination provides supplementary information to ER.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Prohibitin Rabbit Polyclonal
Prostate Specific Antigen (PSA) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E2960
0.1ml
Concentrate
Immunogen: Purified human PSA.
Concentrate
Immunogen: Synthetic peptide corresponding to near C-terminus of human prohibitin protein.
E2962
0.5ml
Concentrate
Concentrate
Application: IHC-P
Application: IHC-P
1.0ml
E2964
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2961
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E17750
0.1ml
Concentrate
E17752
0.5ml
E17754 E17751
Isotype: Rabbit IgG
Clone: N/A
Isotype: Rabbit IgG Control Tissue: Prostate, Prostate Carcinoma
Control Tissue: Heart
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Heart stained with anti-Prohibitin antibody E1775
Human Prostate stained with anti-Prostate Specific Antigen (PSA) antibody E296
Product Description: Prohibitin is an evolutionarily conserved protein located in the inner membrane of mitochondria. Prohibitin appears to be a very reliable marker of mitochondria. Prohibitin shows antiproliferative activity and has been proposed to play a role in normal cell cycle regulation, replicative senescence, cellular immortalization, and tumor suppression.
Product Description: PSA is a chymotrypsin-like serine protease (kallikrein family) exclusively produced by the prostate epithelium, and abundant in seminal fluid. PSA can be detected in the sera of patients with prostatic carcinoma. It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). A higher proportion of serum PSA is complexed to ACT in prostate cancer than in benign prostate hyperplasia.
Prolactin Rabbit Polyclonal
Prostate Stem Cell Antigen (PSCA) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Purified human prolactin.
E3290
0.1ml
Concentrate
Concentrate
Application: IHC-P
E3292
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from extracellular region of human PSCA protein.
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
Ready-to-Use
Species Reactivity: Human*
E3294
7.0ml
E3291
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17490
0.1ml
E17492
0.5ml
E17494 E17491
Isotype: Rabbit IgG
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Control Tissue: Pituitary Cellular Localization: Cytoplasm
Control Tissue: Prostate, Prostate Carcinoma
Human Pituitary stained with anti-Prolactin antibody E1749
Human Prostate Carcinoma stained with anti-Prostate Stem Cell Antigen (PSCA) antibody E329
Cellular Localization: Cytoplasm, Membrane
Product Description: Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. Prolactin producing cells make up approximately 20% of the pituitary.
Product Description: PSCA (Prostate Stem Cell antigen) is a cell surface antigen, which is overexpressed in approximately 40% of primary prostate cancers and in as many as 100% of metastatic ones. PSCA is also overexpressed in a majority of transitional cell and pancreatic carcinomas.
Prostate Apoptosis Response 4 (PAR-4) Rabbit Polyclonal
Protein Gene Protein 9.5 (PGP9.5) Rabbit Polyclonal
Catalog No.
Size
Format
E3420
0.1ml
Concentrate
E3422
0.5ml
Concentrate
E3424
1.0ml
Concentrate
E3421
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size Format
Clone: N/A
Immunogen: Synthetic peptide derived from C-terminus of human prostate apoptosis response 4 protein.
E3340
0.1ml
Concentrate
E3342
0.5ml
Concentrate
Immunogen: Recombinant full length human protein gene product 9.5 protein.
E3344
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P, WB
E3341
7.0ml
Ready-to-Use
Species Reactivity: Human*
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Pancreas, Small Intestine
Control Tissue: Heart
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Cytoplasm
Control Lysate: Human Brain Molecular Weight: 27 kDa
Human Heart stained with anti-Prostate Apoptosis Response 4 (PAR-4) antibody E342
Product Description: Prostate apoptosis response-4 (PAR-4) is a 38kDa protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain-containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. PAR-4 levels are increased in the spinal cord specimens from patients with neuronal degeneration.
Human Pancreas stained with anti-Protein Gene Protein 9.5 (PGP9.5) antibody E334
Product Description: Protein gene product (PGP9.5) is a neuron specific protein distinct from neuron specific enolase. PGP9.5 is present in neurons, nerve fibers, neuroendocrine cells, renal tubules, spermatogonia, Leydig cells of the testis, ova and some cells of both the pregnant and non-pregnant corpus luteum.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
89
PSMA Rabbit Monoclonal
RAD51 Rabbit Polyclonal Clone: SP29
Catalog No.
Size
Format
E19100
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human PSMA.
E19102
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human RAD51 protein.
1.0ml
Concentrate
Application: IHC-P
E19104
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E19101
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3290
0.1ml
Concentrate
M3292
0.5ml
M3294 M3291
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate Carcinoma
Control Tissue: Breast Carcinoma, Tonsil
Cellular Localization: Membrane
Cellular Localization: Nucleus
Human Prostate Carcinoma stained with anti-PSMA antibody M329
Human Breast Carcinoma stained with anti-RAD51 antibody E1910
Product Description: Prostate-specific membrane antigen (PMSA) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. PSMA is involved in prostate tumor progression.
Product Description: RAD51 is a member of the RAD51 protein family involved in repair of DNA double strand breaks. The protein is highly conserved in most eukaryotes from yeast to humans. It can interact with the ssDNA-binding protein RPA and Rad52, and is thought to play roles in homologous pairing and strand transfer of DNA. The interactions between Rad51 with BRCA1 and BRCA2 may be important for the cellular response to DNA damage. RAD51 is overexpressed in a variety of tumors.
PSMA Rabbit Polyclonal
RAN Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E12460
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human PSMA.
E12462
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to aa 197-216 of human RAN protein.
1.0ml
Concentrate
Application: IHC-P
E12464
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E12461
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17330
0.1ml
Concentrate
E17332
0.5ml
E17334 E17331
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate Carcinoma
Control Tissue: Breast
Cellular Localization: Membrane
Cellular Localization: Nucleus
Human Prostate Carcinoma stained with anti-PSMA antibody E1733
Human Breast stained with anti-RAN antibody E1246
Product Description: Prostate-specific membrane antigen (PMSA) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. PSMA is involved in prostate tumor progression.
Product Description: The small Ras-related protein Ran, also called TC4, is a 24kDa, nuclear localized GTPase implicated in a diverse array of cellular processes including DNA replication, entry into and exit from mitosis and the transport of RNA and proteins through the nuclear pore complex.
RACK-1 Rabbit Polyclonal
RCAS1 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E16370
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human RACK-1 protein.
E16372
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human RCAS1.
1.0ml
Concentrate
Application: IHC-P
E16374
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E16371
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18910
0.1ml
Concentrate
E18912
0.5ml
E18914 E18911
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Prostate Carcinoma stained with anti-RACK-1 antibody E1891
Human Breast Carcinoma stained with anti-RCAS1 antibody E1637
Product Description: RACK-1 (receptor for activated C kinase 1) was identified through its binding to various PKC isoforms. Its main function is to recruit PKC and various other proteins to specific locations to form multiprotein complexes, mediating various signal pathways.
90
Clone: N/A
Product Description: RCAS-1 (Receptor binding cancer antigen expressed on SiSo cells) is a type III transmembrane protein mostly in the Golgi. It induces apoptosis of natural killer (NK)/T cells through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. RCAS-1 is abundantly expressed in prostate cancer cells when compared to normal epithelial cells.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies RCC1 Rabbit Polyclonal
Retinoic X Receptor gamma Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E4330
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human RCC1.
E4332
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of mouse RXR gamma.
1.0ml
Concentrate
Application: IHC-P
E4334
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4331
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E13440
0.1ml
Concentrate
E13442
0.5ml
E13444 E13441
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma
Control Tissue: Breast, Prostate Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Nucleus Control Lysate: NIH3T3 Molecular Weight: 60 kDa
Human Colon Carcinoma stained with anti-RCC1 antibody E1344
Human Prostate Carcinoma stained with anti-Retinoic X Receptor gamma antibody E433
Product Description: Regulator of Chromosome Condensation 1 (RCC-1) binds to chromatin and participates in the regulation of chromosome condensation in the S phase. RCC-1 interacts with GTP-binding nuclear protein Ran and catalyzes guanine nucleotide exchange. Both RCC-1 and Ran are components of an intrinsic checkpoint control that prevents the premature initiation of mitosis.
Product Description: Retinoids are metabolites of vitamin A and represent important signaling molecules during vertebrate development and tissue differentiation. Two families of retinoid receptors have been identified: retinoic acid receptors (RAR-α, RAR-β and RAR-γ); and retinoid X receptors (RXR-α, RXR-β and RXR-γ). RXRs are activated by 9-cis-retinoic acid, a stereo- and photoisomer of all-trans-RA expressed in vivo in both liver and kidney.
Retinoblastoma (Rb) Rabbit Polyclonal
RHO Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17850
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human retinoblastoma.
E17852
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to human Rho protein.
1.0ml
Concentrate
Application: IHC-P
E17854
1.0ml
Concentrate
Application: WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
N/A
N/A
N/A
Catalog No.
Size
Format
E4310
0.1ml
Concentrate
E4312
0.5ml
E4314 E4311
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Colon Carcinoma
Control Tissue: N/A
Cellular Localization: Nucleus
Cellular Localization: N/A Control Lysate: MCF7 Molecular Weight: 21 kDa
Human Colon Carcinoma stained with anti-Retinoblastoma (Rb) antibody E431
N/A E1785
Product Description: Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth.
Product Description: The RHO proteins are members of the Ras superfamily of small GTP-binding proteins. The RHO proteins play an important role in the organization of actin cytoskeleton, cell adhesion, cell motility and smooth muscle contraction. The RHO proteins are also involved in the signal transduction pathways mediated by the actin cytoskeleton and the activation of the stress activated MAP kinase cascades.
Retinoic Acid Receptor beta Rabbit Polyclonal
ROC1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size Format
Clone: N/A
E4190
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human RAR beta.
E4192
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human ROC1.
1.0ml
Concentrate
Application: IHC-P
E4194
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4191
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E4370
0.1ml
Concentrate
E4372
0.5ml
E4374 E4371
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Heart, Testis
Control Tissue: Tonsil
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Testis stained with anti-Retinoic Acid Receptor beta antibody E437
Human Tonsil stained with anti-ROC1 antibody E419
Product Description: Retinoids are metabolites of vitamin A and represent important signaling molecules during vertebrate development and tissue differentiation. Two families of retinoid receptors have been identified: retinoic acid receptors (RARs-α, -β and -γ); and retinoid X receptors (RXR-α, -β and -γ). RXRs have a high affinity for all-trans retinoic acids and belong to the same class of nuclear transcription factors such as thyroid hormone receptors and vitamin D3 receptor.
Product Description: ROC1 and ROC2 are the two highly conserved RING finger proteins that are homologous to APC11, a subunit of the anaphase-promoting complex (APC). ROC1 and ROC2 commonly interact with all cullins. ROC1 and APC11 immunocomplexes can catalyze isopeptide ligations to form polyubiquitin chains in an E1- and E2dependent manner. ROC1 is thought to play a unique role in the ubiquitination reaction by heterodimerizing with cullin1 to catalyze ubiquitin polymerization.
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International Orders Email: intlorders@springbio.com
91
RRM1 Rabbit Polyclonal
S6 Ribosomal Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E17780
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human RRM1.
E17782
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human S6 ribosomal.
1.0ml
Concentrate
Application: IHC-P
E17784
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E17781
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18040
0.1ml
Concentrate
E18042
0.5ml
E18044 E18041
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Cytoplasm Control Lysate: NIH3T3 Molecular Weight: 32 kDa
Human Placenta stained with anti-RRMI antibody E1804
Human Breast Carcinoma stained with anti-S6 Ribosomal antibody E1778
Product Description: RRM1 (Ribonucleotide reductase M1 polypeptide) is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is involved in carcinogenesis and tumor progression.
Product Description: 40S ribosomal protein S6 (also known as RPS6) is a 31kDa substrate of p70 S6 kinase (p70S6K) and a major component of translational machinery involved in protein synthesis, cell growth, proliferation, and metabolism. RPS6 undergoes phosphorylation on multiple serines in the carboxyl terminal region in the order 236-->235-->240-->244-->247. Hyperphosphorylation of RPS6 stimulates protein synthesis that mediates progression through the cell cycle.
S100 Rabbit Polyclonal
S6 Ribosomal (Paired 235/236) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18080
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding human S100 protein.
E18082
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E18084
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18081
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2140
0.1ml
Concentrate
E2142
0.5ml
E2144 E2141
Isotype: Rabbit IgG
Clone: N/A Immunogen: Synthetic peptide derived from the region of human S6 ribosomal that contains unphosphorylated serines 235 and 236. Application: IHC-P, WB Species Reactivity: Human*
Control Tissue: Melanoma, Schwannoma
Isotype: Rabbit IgG
Cellular Localization: Cytoplasm
Control Tissue: Breast Carcinoma Cellular Localization: Cytoplasm Control Lysate: 293T Molecular Weight: 32 kDa
Human Melanoma stained with anti-S100 antibody E214
Human Breast Carcinoma stained with anti-S6 Ribosomal (Paired 235/236) antibody E1808
Product Description: S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. The antibody to S100 stains schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells.
Product Description: 40S ribosomal protein S6 (RPS6) is a substrate of p70 S6 kinase (p70S6K) and a major component of translational machinery involved in protein synthesis, cell growth, proliferation, and metabolism. RPS6 undergoes phosphorylation on multiple serines in the carboxyl terminal region in the order 236-->235-->240-->244->247. This antibody detects non-phosphorylated S6 ribosomal at 235/236 serine residue.
S100A4 Rabbit Polyclonal
S6 Ribosomal (Paired 240/244) Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E17770
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding full length human S100A4.
E17772
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P, WB
E17774
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E17771
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4440
0.1ml
Concentrate
E4442
0.5ml
E4444 E4441
Isotype: Rabbit IgG Control Tissue: Melanoma, Tonsil Cellular Localization: Cytoplasm Control Lysate: Human Placenta
Clone: N/A Immunogen: Synthetic peptide derived from the region of human S6 ribosomal that contains nonphosphorylated serines 240 and 244. Application: IHC-P Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Breast Carcinoma Cellular Localization: Cytoplasm
Molecular Weight: 12 kDa Human Tonsil stained with anti-S100A4 antibody E444
Product Description: S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph node.
92
Human Breast Carcinoma stained with anti-S6 Ribosomal (Paired 240/244) antibody E1777
Product Description: 40S ribosomal protein S6 (RPS6) is a substrate of p70 S6 kinase (p70S6K) and a major component of translational machinery involved in protein synthesis, cell growth, proliferation, and metabolism. RPS6 undergoes phosphorylation on multiple serines in the carboxyl terminal region in the order 236-->235-->240-->244->247. Hyperphosphorylation of RPS6 stimulates protein synthesis. This antibody detects non-phosphorylated S6 ribosomal at 240/244 serine residue.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies S6 Ribosomal (Phospho S235/236) Rabbit Monoclonal Catalog No.
Size
Format
M3500
0.1ml
Concentrate
M3502
0.5ml
Concentrate
M3504
1.0ml
Concentrate
M3501
7.0ml
Ready-to-Use
S6 Ribosomal (Phospho S240/244) Rabbit Polyclonal
Clone: SP50
Catalog No.
Size
Format
Immunogen: Synthetic peptide derived from the region of human S6 ribosomal that contains phosphorylated serines 235 and 236.
E17760
0.1ml
Concentrate
E17762
0.5ml
Concentrate
E17764
1.0ml
Concentrate
Application: IHC-P
E17761
7.0ml
Ready-to-Use
Clone: N/A Immunogen: Synthetic peptide derived from the region of human S6 ribosomal that contains phosphorylated serines 240 and 244. Application: IHC-P
Species Reactivity: Human*
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Breast Carcinoma stained with anti-S6 Ribosomal (Phospho S235/236) antibody M350
Human Breast Carcinoma stained with anti-S6 Ribosomal (Phospho S240/244) antibody E1776
Product Description: 40S ribosomal protein S6 (RPS6) is a substrate of p70 S6 kinase (p70S6K) and a major component of translational machinery involved in protein synthesis, cell growth, proliferation, and metabolism. RPS6 undergoes phosphorylation on multiple serines in the carboxyl terminal region in the order 236-->235-->240-->244->247. Hyperphosphorylation of RPS6 stimulates protein synthesis. This antibody detects S6 ribosomal only when it is phosphorylated at 235/236 serine residue.
Product Description: 40S ribosomal protein S6 (RPS6) is a substrate of p70 S6 kinase (p70S6K) and a major component of translational machinery involved in protein synthesis, cell growth, proliferation, and metabolism. RPS6 undergoes phosphorylation on multiple serines in the carboxyl terminal region in the order 236-->235-->240-->244->247. Hyperphosphorylation of RPS6 stimulates protein synthesis. This antibody detects S6 Ribosomal only when it is phosphorylated at 240/244 serine residue.
S6 Ribosomal (Phospho S235/236) Rabbit Polyclonal
SHIP-1 Rabbit Polyclonal
Catalog No.
Size
Format
E18070
0.1ml
Concentrate
E18072
0.5ml
Concentrate
E18074
1.0ml
Concentrate
E18071
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide derived from the region of human S6 ribosomal that contains phosphorylated serines 235 and 236.
E14060
0.1ml
Concentrate
E14062
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human SHIP-1.
Application: IHC-P
E14064
1.0ml
Concentrate
Application: IHC-P
E14061
7.0ml
Ready-to-Use
Species Reactivity: Human*
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Breast Carcinoma
Cellular Localization: Membrane
Cellular Localization: Cytoplasm
Human Breast Carcinoma stained with anti-S6 Ribosomal (Phospho S235/236) antibody E1807
Human Tonsil stained with anti-SHIP-1 antibody E1406
Product Description: 40S ribosomal protein S6 (RPS6) is a substrate of p70 S6 kinase (p70S6K) and a major component of translational machinery involved in protein synthesis, cell growth, proliferation, and metabolism. RPS6 undergoes phosphorylation on multiple serines in the carboxyl terminal region in the order 236-->235-->240-->244->247. Hyperphosphorylation of RPS6 stimulates protein synthesis. This antibody detects S6 ribosomal only when it is phosphorylated at 235/236 serine residue.
Product Description: SHIP-1 p145 (SH2-containing-inositol phosphatase) contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1, 3, 4, 5 -tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways.
S6 Ribosomal (Phospho S240/244) Rabbit Monoclonal
SH-PTP2 Rabbit Polyclonal
Catalog No.
Size
Format
M3450
0.1ml
Concentrate
M3452
0.5ml
Concentrate
M3454
1.0ml
Concentrate
M3451
7.0ml
Ready-to-Use
Clone: SP45
Catalog No.
Size Format
Clone: N/A
Immunogen: Synthetic peptide derived from the region of human S6 ribosomal that contains phosphorylated serines 240 and 244.
E12440
0.1ml
Concentrate
E12442
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to aa 576-593 of human SH-PTP2 protein.
Application: IHC-P
E12444
1.0ml
Concentrate
Application: IHC-P
E12441
7.0ml
Ready-to-Use
Species Reactivity: Human*
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bone Marrow
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Breast Carcinoma stained with anti-S6 Ribosomal (Phospho S240/244) antibody M345
Product Description: 40S ribosomal protein S6 (RPS6) is a 31kDa substrate of p70 S6 kinase (p70S6K) and a major component of translational machinery involved in protein synthesis, cell growth, proliferation, and metabolism. RPS6 undergoes phosphorylation on multiple serines in the carboxyl terminal region in the order 236-->235-->240-->244->247. This antibody detects S6 ribosomal only when it is phosphorylated at 240/244 serine residue.
Human Bone Marrow stained with anti-SH-PTP2 antibody E1244
Product Description: The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). SH-PTP1 is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH-PTP2 works on the downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
93
SKP1 p19 Rabbit Polyclonal Catalog No.
Size
Format
E14120
0.1ml
Concentrate
E14122
0.5ml
Concentrate
E14124
1.0ml
Concentrate
E14121
7.0ml
Ready-to-Use
SLIT2 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to C-terminus of human SKP1 p19.
E19050
0.1ml
Concentrate
E19052
0.5ml
Concentrate
Immunogen: Synthetic peptide near N-terminus of human SLIT2.
E19054
1.0ml
Concentrate
Application: IHC-P, WB
Application: IHC-P
E19051
7.0ml
Ready-to-Use
Species Reactivity: Human*
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Fetal Kidney, Prostate Carcinoma
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus Control Lysate: NIH3T3 Molecular Weight: 19 kDa
Human Prostate Carcinoma stained with anti-SLIT2 antibody E1905
Human Breast Carcinoma stained with anti-SKP1 p19 antibody E1412
Product Description: SKP1 p19 and SKP2 p45 are two cyclin A-CDK2 complex binding proteins participating in cell cycle regulation. Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin dependent kinase-2 (CDK2). Although the Skps (S phase kinaseassociated proteins) associate with the active cyclin A-Cdk2 complex, they do not exhibit any regulatory effects on the complex.
Product Description: Slit homolog 2 proteins (SLIT2) are ligands for the Roundabout (Robo) receptors and act as molecule guidance cues in cell migration. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Slit2 protein is expressed in fetal lung and kidney, and adult spinal cord. SLIT2 is a target for repression by EZH2 and is up-regulated in prostate cancer.
SKP2 p45 Rabbit Polyclonal
SMA Rabbit Polyclonal Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E19220
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa 221-425 of human SKP2 alpha.
E19222
0.5ml
Concentrate
Immunogen: Synthetic peptide near the N-terminus of human smooth muscle actin-alpha.
1.0ml
Concentrate
Application: IHC-P
E19224
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E19221
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E13880
0.1ml
Concentrate
E13882
0.5ml
E13884 E13881
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate
Control Tissue: Colon, Small Intestine
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Cytoplasm
Human Prostate stained with anti-SKP2 p45 antibody E1388
Human Small Intestine stained with anti-SMA antibody E1922
Product Description: SKP2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the cyclin A-CDK2 complex. SKP2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. SKP2 is widely expressed in normal and cancer tissues such as tonsil, placenta and cancers from colon, prostate, pancreas, skin, lung, breast, ovarian, and endometrium. SKP2 plays a role in oncogenesis, particularly in lymphomas and breast cancers.
Product Description: Smooth muscle actin-alpha is a cytoskeleton protein in smooth muscle cells and their derived tumors such as leiomyoma and leiomyosarcoma. It is also expressed in myoepithelial cells of the breast and salivary gland, but not in fibroblasts, striated muscle, and myocardium.
SLIT2 Rabbit Monoclonal
SMAD3 Rabbit Polyclonal Catalog No.
Size
Format
E11250
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human SLIT2 protein.
E11252
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human SMAD3.
1.0ml
Concentrate
Application: IHC-P
E11254
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*, Mouse*
E11251
7.0ml
Ready-to-Use
Size
Format
M4220
0.1ml
Concentrate
M4222
0.5ml
M4224 M4221
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate Adenocarcinoma
Control Tissue: Breast, Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus
Human Prostate Adenocarcinoma stained with anti-SLIT2 antibody M422
Human Breast Carcinoma stained with anti-SMAD3 antibody E1125
Product Description: SLIT2 are ligands for Robo receptors and play a vital role for axonal migration/navigation during neural development. A number of cleavage products through alternate splicing are reported in the literature for SLIT2 proteins. The C-terminal cleavage proteins are more diffusible than the larger N-terminal protein that is more tightly cell associated. SLIT2 protein is expressed in tissues such as fetal lung, kidney, and adult spinal cord.
94
Clone: N/A
Clone: SP122
Catalog No.
Product Description: SMAD proteins mediate signaling events leading to transcriptional activation initiated by members of the TGF-beta superfamily. Biological activities mediated by smads include cell growth and morphogenesis, development, and immune response. A reduction in SMAD2/3 signaling enhances tumorigenesis, but also suppresses metastasis of breast cancer cell lines.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies SMRTe Rabbit Polyclonal
SOCS-6 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E16780
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to aa 994-1005 of human SMRTe protein.
E16782
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human SOCS-6 protein.
1.0ml
Concentrate
Application: IHC-P
E16784
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E16781
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10990
0.1ml
Concentrate
E10992
0.5ml
E10994 E10991
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain, Lung Carcinoma
Control Tissue: Placenta
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm
Human Brain stained with anti-SMRTe antibody E1099
Human Placenta stained with anti-SOCS-6 antibody E1678
Product Description: SMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cyclespecific gene expression in diverse signaling pathways.
Product Description: Suppressor of Cytokine Signaling 6 (SOCS-6) interacts with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) overexpressing human IR. SOCS-1 and SOCS-6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. SOCS-6 proteins may be inhibitors of IR signaling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes.
SOCS-2 Rabbit Polyclonal
Sodium Channel-pan Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E10290
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human SOCS-2 protein.
E10292
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E10294
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E10291
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16720
0.1ml
Concentrate
E16722
0.5ml
E16724 E16721
Clone: N/A Immunogen: Synthetic peptide from C-terminus of the alpha subunit of rat type 1 voltage-gated sodium channel. Application: IHC-P Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Pancreas Cellular Localization: Cytoplasm
Control Tissue: Brain
Human Pancreas stained with anti-SOCS-2 antibody E1672
Human Brain stained with anti-Sodium Channel-pan antibody E1029
Cellular Localization: Cytoplasm
Product Description: Suppressor of Cytokine Signaling (SOCS) includes eight members of SOCS family (SOCS-1, 2, 3, 4, 5, 6, 7 and CIS). Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminus motif called the SOCS box. The SOCS-2 appear to form part of a classical negative feed back loop that regulates cytokine signal transduction.
Product Description: Voltage-gated sodium channels (VGSC) are present in most excitable cells. In neuronal tissue, they are responsible for generating and propagating action potentials. Brain VGSCs are heteromers of αβ1β2 subunits. Of these, the α subunit forms the channel pore. This antibody recognizes the alpha subunit of type I voltagegated sodium channel.
SOCS-3 Rabbit Polyclonal
Sonic Hedgehog Rabbit Polyclonal Clone: N/A
Catalog No.
Size Format
Clone: N/A
E17920
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human SOCS-3 protein.
E17922
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human sonic hedgehog.
1.0ml
Concentrate
Application: IHC-P
E17924
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E17921
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E16850
0.1ml
Concentrate
E16852
0.5ml
E16854 E16851
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta, Testis
Control Tissue: Fetal Brain, Lung
Cellular Localization: Cytoplasm
Cellular Localization: Extracellular Matrix, Membrane
Human Placenta stained with anti-SOCS-3 antibody E1685
Human Lung stained with anti-Sonic Hedgehog antibody E1792
Product Description: Suppressor of Cytokine Signaling 3 (SOCS-3) is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. It inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. It suppresses fetal liver erythropoiesis and regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells.
Product Description: Sonic Hedgehog (SHH) is expressed only during embryogenesis and is instrumental in patterning in the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
95
SOX-2 Rabbit Monoclonal Catalog No.
Size
Format
M3760
0.1ml
Concentrate
M3762
0.5ml
Concentrate
M3764
1.0ml
Concentrate
M3761
7.0ml
Ready-to-Use
SOX-9 Rabbit Polyclonal Clone: SP76
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to N-terminus of human SOX-2 protein.
E14040
0.1ml
Concentrate
E14042
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 316-510 of human SOX-9 protein.
E14044
1.0ml
Concentrate
Application: IHC-P, WB
Application: IHC-P
E14041
7.0ml
Ready-to-Use
Species Reactivity: Human*, Mouse*
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Testis
Control Tissue: Newborn Brain
Cellular Localization: Nucleus
Cellular Localization: Nucleus Control Lysate: MCF7 Molecular Weight: 34 kDa
Human Testis stained with anti-SOX-9 antibody E1404
Human Newborn Brain stained with anti-SOX-2 antibody M376
Product Description: SOX-2 is also known as SRY related HMG BOX gene 2. It is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. It is critical for early embryogenesis and for embryonic stem cell pluripotency. SOX-2 is highly expressed in glioma, lung cancer and stomach cancer.
Product Description: SOX-9 is a member of the SOX family (Sry-type high mobility group box) genes that was first identified on the basis of region with high homology to that of SRY (Sex-determining region Y). SOX-9 is a transcription factor with a high mobility group DNA-binding domain in all prechondrocytic and chondrocytic cells during embryonic development. SOX-9 regulates expression of chondrocyte phenotype related genes.
SOX-2 Rabbit Polyclonal
SOX-9 Rabbit Polyclonal Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E13470
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human SOX-2 protein
E13472
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 1-150 of human SOX-9 protein.
1.0ml
Concentrate
Application: IHC-P
E13474
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E13471
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18600
0.1ml
Concentrate
E18602
0.5ml
E18604 E18601
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Newborn Brain, Skin
Control Tissue: Testis
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Newborn Brain stained with anti-SOX-2 antibody E1860
Human Testis stained with anti-SOX-9 antibody E1347
Product Description: SOX-2 is also known as SRY related HMG BOX gene 2. It is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. It is critical for early embryogenesis and for embryonic stem cell pluripotency. SOX-2 is highly expressed in glioma, lung cancer and stomach cancer.
Product Description: SOX-9 is a member of the SOX family (Sry-type high mobility group box) genes that was first identified on the basis of region with high homology to that of SRY (Sex-determining region Y). SOX-9 is a transcription factor with a high mobility group DNA-binding domain in all prechondrocytic and chondrocytic cells during embryonic development. SOX-9 regulates expression of chondrocyte phenotype related genes.
SOX-4 Rabbit Polyclonal
SOX-11 Rabbit Polyclonal Catalog No.
Size
Format
E18760
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to internal region of human SOX-4 protein.
E18762
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human SOX-11 protein.
1.0ml
Concentrate
Application: IHC-P
E18764
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18761
7.0ml
Ready-to-Use
Size
Format
E16380
0.1ml
Concentrate
E16382
0.5ml
E16384 E16381
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain
Control Tissue: Mantle Cell Lymphoma
Cellular Localization: Nucleus
Cellular Localization: Nucleus
Human Brain stained with anti-SOX-4 antibody E1638
Human Mantle Cell Lymphoma stained with anti-SOX-11 antibody E1876
Product Description: SOX-4 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. SOX-4 binds with high affinity to the T cell enhancer motif 5’-AACAAAG-3’ motif. Sox-4 is expressed in lymphocytes (B and T) and it is required for B lymphocyte development. It is also expressed in breast, breast cancer, medulloblastoma, and prostate cancer.
96
Clone: N/A
Clone: N/A
Catalog No.
Product Description: The SOX (SRY-related HMG-box) family are transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. All SOX proteins have a single HMG box and bind linear DNA. SOX-1, SOX-2 and SOX-3 show the closest homology to SRY. SOX-11 appears to be important in the development of nervous system and tissue modeling during development.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies SOX-14 Rabbit Polyclonal
Stanniocalcin-2 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E18840
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human SOX-14 protein.
E18842
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human stanniocalcin-2 protein.
1.0ml
Concentrate
Application: IHC-P
E18844
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E18841
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16820
0.1ml
Concentrate
E16822
0.5ml
E16824 E16821
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Fetal Brain
Control Tissue: Small Intestine
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm
Human Fetal Brain stained with anti-SOX-14 antibody E1682
Human Small Intestine stained with anti-Stanniocalcin-2 antibody E1884
Product Description: The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNAbinding domain. They are involved in the regulation of embryonic development and in the determination of cell fate (specifically neuronal). SOX-14 is most closely related to SOX factors 1, 2 and 3 and likely mirrors expression of these genes in the developing brain and spinal cord.
Product Description: Stanniocalcin-2 is a homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport and cell metabolism. In the ovary, it has been shown to be a paracrine hormone that regulates granulosa cell function. Expression of this gene is induced by estrogen and altered in some breast cancers.
SP1 Rabbit Polyclonal
STAT3 Rabbit Polyclonal Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E3690
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human SP1.
E3692
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 50-240 of human Stat3.
1.0ml
Concentrate
Application: IHC-P
E3694
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3691
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12540
0.1ml
Concentrate
E12542
0.5ml
E12544 E12541
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Breast Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm, Nucleus
Human Tonsil stained with anti-SP1 antibody E1254
Human Breast Carcinoma stained with anti-STAT3 antibody E369
Product Description: SP1 is a sequence-specific transcription factor that recognizes GGGGCGGGGC and closely related sequences, which are often referred to as GC boxes. SP1 belongs to a subgroup of transcription factors that are phosphorylated upon binding to promoter sequences.
Product Description: The STAT3 protein is a transcription factor expressed in most cell types and is activated by multiple cytokines and growth factors including: IFN-a, IL-10, IL-6, IL-11, IL-12, IL-2, EGF etc. STAT3 binds to DNA as either a homodimer or as a heterodimer with STAT1. STAT3 interacts with the APRE (acute phase response element) and SIE (c-sis inducible element).
ST13 Rabbit Polyclonal
STAT5 alpha Rabbit Polyclonal Clone: N/A
Catalog No.
Size Format
Clone: N/A
E3590
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to human ST13.
E3592
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human STAT5 alpha.
1.0ml
Concentrate
Application: IHC-P
E3594
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3591
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E17870
0.1ml
Concentrate
E17872
0.5ml
E17874 E17871
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma
Control Tissue: Breast Carcinoma, Tonsil
Cellular Localization: Nucleus
Cellular Localization: Nucleus Control Lysate: K562 Molecular Weight: 95 kDa Human Breast Carcinoma stained with anti-STAT5 alpha antibody E359
Human Colon Carcinoma stained with anti-ST13 antibody E1787
Product Description: ST13 is a cofactor of heat shock protein 70 (HSP70). To date, all data since the discovery of ST13 in 1993 until more recent studies in 2007 have proved that ST13 is down regulated in tumors and it is proposed to be a tumor suppressor gene.
Product Description: STAT5a protein is a transcription factor activated by hormone and cytokines. Two highly related, but distinct STAT5 genes (STAT5a and STAT5b) were identified in mouse. STAT5a is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
97
STAT6 Rabbit Polyclonal
Survivin Rabbit Monoclonal Clone: N/A
Catalog No.
Size
Format
M3790
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human STAT6.
M3792
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
M3794 M3791
1.0ml 7.0ml
Concentrate Ready-to-Use
Catalog No.
Size
Format
E4290
0.1ml
Concentrate
E4292
0.5ml
E4294 E4291
Species Reactivity: Human*
Clone: SP79 Immunogen: Synthetic peptide corresponding to C-terminus of human survivin protein. Application: IHC-P Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta, Tonsil
Control Tissue: Stomach
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Cytoplasm
Human Placenta stained with anti-STAT6 antibody E429
Human Stomach stained with anti-Survivin antibody M379
Product Description: STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. STAT6 was found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, and T-cell proliferation. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response.
Product Description: Survivin is an inhibitor of apoptosis (IAP) protein. It is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.
Stathmin Rabbit Monoclonal
Survivin Rabbit Polyclonal Clone: SP49
Catalog No.
Size
Format
E3770
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human stathmin.
E3772
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human survivin.
1.0ml
Concentrate
Application: IHC-P, WB
E3774
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*, Mouse*
E3771
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3490
0.1ml
Concentrate
M3492
0.5ml
M3494 M3491
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Stomach
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Control Lysate: NIH3T3 Molecular Weight: 18 kDa Human Stomach stained with anti-Survivin antibody E377
Human Tonsil stained with anti-Stathmin antibody M349
Product Description: Stathmin is a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Alternatively spliced transcript variants encoding the same protein have been identified.
Product Description: Survivin is an inhibitor of apoptosis (IAP) protein. It is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.
Stathmin Rabbit Polyclonal
SYK Rabbit Polyclonal Catalog No.
Size
Format
E4050
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human stathmin.
E4052
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal region of human SYK protein.
1.0ml
Concentrate
Application: IHC-P, WB
E4054
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4051
7.0ml
Ready-to-Use
Size
Format
E18060
0.1ml
Concentrate
E18062
0.5ml
E18064 E18061
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Tonsil
Control Tissue: Bone Marrow, Lymphoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Control Lysate: NIH3T3
Control Lysate: HepG2
Molecular Weight: 18 KDa
Molecular Weight: 72 KDa
Human Breast Carcinoma stained with anti-Stathmin antibody E1806
Human Bone Marrow stained with anti-SYK antibody E405
Product Description: Stathmin is a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Alternatively spliced transcript variants encoding the same protein have been identified.
98
Clone: N/A
Clone: N/A
Catalog No.
Product Description: SYK, a protein tyrosine kinase (PTK) is expressed in immature T cells, all B cells, basophils, hepatocytes, platelets, and erythrocytes. It functions in some T cell receptor signaling processes in addition to B cell receptor and integrin-mediated signal transduction processes. SYM-/syk- mice exhibit defective phagocytosis by macrophages.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Synaptophysin Rabbit Monoclonal Catalog No.
Size
Format
M3110
0.1ml
Concentrate
M3112
0.5ml
Concentrate
M3114
1.0ml
Concentrate
M3111
7.0ml
Ready-to-Use
Syntaxin 1A Rabbit Polyclonal
Clone: SP11
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to C-terminus of human synaptophysin.
E17700
0.1ml
Concentrate
E17702
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human syntaxin 1A protein.
E17704
1.0ml
Concentrate
Application: IHC-P, WB
Application: IHC-P
E17701
7.0ml
Ready-to-Use
Species Reactivity: Human*
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain
Control Tissue: Breast Neuroendocrine Tumor, Pancreas, Pheochromcytoma
Cellular Localization: Membrane
Cellular Localization: Cytoplasm Control Lysate: Human Brain Molecular Weight: 38 kDa
Human Brain stained with anti-Syntaxin 1A antibody E1770
Human Neuroendocrine Tumor stained with anti-Synaptophysin antibody M311
Product Description: Synaptophysin is expressed in neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, gastrointestinal mucosa, Paneth’s cells in the gastrointestinal tract and of gastric parietal cells, neurons in the brain, spinal cord, and retina. It is also expressed in neuroendocrine tumors such as neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, chromaffin, and non-chromaffin paragangliomas.
Product Description: Syntaxin 1A (STX1A) is potentially involved in docking of synaptic vesicles at presynaptic active zones and may play a critical role in neurotransmitter exocytosis. Haploinsufficiency of STX1A may be the cause of certain cardiovascular and musculoskeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.
Synaptophysin Rabbit Polyclonal
Synuclein-alpha Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2680
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide of human synaptophysin.
E2682
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to near C-terminus of human synuclein-alpha.
1.0ml
Concentrate
Application: IHC-P
E2684
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E2681
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2170
0.1ml
Concentrate
E2172
0.5ml
E2174 E2171
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Pancreas
Control Tissue: Brain (Posterior Cingulated Gyrus)
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Presynaptic Terminals
Human Pancreas stained with anti-Synaptophysin antibody E217
Human Brain stained with anti-Synuclein-alpha antibody E268
Product Description: Synaptophysin is expressed in neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, gastrointestinal mucosa, Paneth’s cells in the gastrointestinal tract and of gastric parietal cells, neurons in the brain, spinal cord, and retina. It is also expressed in neuroendocrine tumors such as neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, chromaffin, and non-chromaffin paragangliomas.
Product Description: Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. The alpha- and beta-synuclein proteins are found primarily in brain tissue, where they are seen mainly in presynaptic terminals. This antibody is specific for alpha-synuclein and is useful for the localization and detection of alpha-synuclein.
Syntaxin 1A Rabbit Monoclonal
Synuclein-beta Rabbit Polyclonal
Clone: SP36
Catalog No.
Size Format
Clone: N/A
E2770
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human syntaxin 1A protein.
E2772
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from near C-terminus of human synuclein-beta.
1.0ml
Concentrate
Application: IHC-P
E2774
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*, Mouse*
E2771
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
M3360
0.1ml
Concentrate
M3362
0.5ml
M3364 M3361
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain
Control Tissue: Brain (Posterior Cingulated Gyrus)
Cellular Localization: Membrane
Cellular Localization: Cytoplasm, Presynaptic Terminals
Human Brain stained with anti-Syntaxin 1A antibody M336
Human Brain stained with anti-Synuclein-beta antibody E277
Product Description: Syntaxin 1A (STX1A) is potentially involved in docking of synaptic vesicles at presynaptic active zones and may play a critical role in neurotransmitter exocytosis. Haploinsufficiency of STX1A may be the cause of certain cardiovascular and musculoskeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.
Product Description: Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. The alpha- and beta-synuclein proteins are found primarily in brain tissue, where they are seen mainly in presynaptic terminals. This antibody is specific for beta-synuclein and does not cross react with alpha-and gammasynuclein.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
99
Synuclein-pan Rabbit Polyclonal
TdT Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E19230
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from near N-terminus of human α, β, γ-Synuclein protein.
E19232
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
E19234 E19231
1.0ml 7.0ml
Concentrate Ready-to-Use
Catalog No.
Size
Format
E2790
0.1ml
Concentrate
E2792
0.5ml
E2794 E2791
Species Reactivity: Human*
Clone: N/A Immunogen: Synthetic peptide in the internal region of human TdT protein. Application: IHC-P Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain (Posterior Cingulated Gyrus)
Control Tissue: Thymus, Thymomas
Cellular Localization: Cytoplasm, Presynaptic Terminals
Cellular Localization: Nucleus
Human Brain stained with anti-Synuclein-pan antibody E279
Human Thymus stained with anti-TdT antibody E1923
Product Description: Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. The alpha- and beta- synuclein proteins are found primarily in brain tissue. This antibody detects all synuclein proteins.
Product Description: Terminal deoxynucleotidyl transferase (TdT) is a nuclear DNA polymerase responsible for the template-independent addition of N-nucleotides. It is expressed in normal hematopoietic cells, normal cortical thymocytes (immature, pre-B, pre-T lymphoid cells), and megakaryocytes of the bone marrow as well as acute lymphoblastic leukemia/lymphoma cells.
Tau (Neuronal Marker) Rabbit Monoclonal
Thioredoxin Reductase 2 (TrxR2) Rabbit Polyclonal
Clone: SP70
Catalog No.
Size
Format
E3610
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human tau protein.
E3612
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human TrxR2.
1.0ml
Concentrate
Application: IHC-P
E3614
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3611
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3700
0.1ml
Concentrate
M3702
0.5ml
M3704 M3701
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Liver Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Breast Carcinoma stained with anti-Tau (Neuronal Marker) antibody M370
Human Liver Carcinoma stained with anti-Thioredoxin Reductase 2 (TrxR2) antibody E361
Product Description: Tau is a neuronal microtubule associated protein found mainly on axons. Its function is to promote tubulin polymerization and stabilize microtubules and to link certain signaling pathways to the cytoskeleton. Tau is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer’s disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destruction of microtubules and neurons in AD brain.
Product Description: The reduced form of thioredoxin serves as a hydrogen donor, contributes to the up-regulation of various transcription factors and binds to and inhibits MAPKKK activity. Oxidized thioredoxin is converted back to the reduced form by Thioredoxin Reductase (TrxR2), a redox active enzyme. There are two distinct isoforms in mammalian cells, TrxR1, a cytosolic protein and TrxR2, almost exclusively a mitochondrial protein. TrxR expression is induced in several tumors.
Tau (Neuronal Marker) Rabbit Polyclonal
Thrombin R/ATAP2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E12530
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to N-terminus of human tau protein.
E12532
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E12534
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E12531
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18290
0.1ml
Concentrate
E18292
0.5ml
E18294 E18291
Isotype: Rabbit IgG Control Tissue: Alzheimer’s Brain, Breast Carcinoma Cellular Localization: Cytoplasm
Clone: N/A Immunogen: Synthetic peptide corresponding to near N-terminus of human thrombin R. Application: IHC-P, WB Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Pancreas Cellular Localization: Cytoplasm, Membrane Control Lysate: HeLa Molecular Weight: 66 kDa
Human Breast Carcinoma stained with anti-Tau (Neuronal Marker) antibody E1829
Product Description: Tau is a neuronal microtubule associated protein found mainly on axons. Its function is to promote tubulin polymerization and stabilize microtubules and to link certain signaling pathways to the cytoskeleton. Tau is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer’s disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destruction of microtubules and neurons in AD brain.
100
Human Pancreas stained with anti-Thrombin R/ATAP2 antibody E1253
Product Description: Thrombin is a serine protease that is involved in platelet aggregation and blood coagulation. It is cleaved from its precursor, prothrombin, and converts fibrinogen to fibrin in the final step of the clotting cascade. Thrombin mediates its regulatory effects by activating cell surface G-protein coupled receptors which include PAR-1, PAR-2 and PAR3.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Thymidylate Synthase (TS) Rabbit Monoclonal
Thyroglobulin Mouse Monoclonal
Clone: SP112
Catalog No.
Size
Format
E16600
0.1ml
Concentrate
Immunogen: Human thyroglobulin.
Concentrate
Immunogen: Synthetic peptide near C-terminus of human TS.
E16602
0.5ml
Concentrate
Concentrate
Application: IHC-P
Application: IHC-P
1.0ml
E16604
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E16601
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
M4120
0.1ml
Concentrate
M4122
0.5ml
M4124 M4121
Isotype: Rabbit IgG
Clone: SPM517
Isotype: Mouse IgG1 Control Tissue: Thyroid
Control Tissue: Colon Carcinoma, Tonsil
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Nucleus
Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody M412
Human Thyroid stained with anti-Thyroglobulin antibody E1660
Product Description: Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma.
Product Description: Thyroglobulin is expressed in thyroid carcinomas of the papillary and follicular types. Adenocarcinomas of non-thyroid origin are not reactive.
Thymidylate Synthase (TS) Rabbit Polyclonal
Thyroid Hormone Receptor alpha1/alpha2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4060
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human TS protein.
E4062
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
E4064 E4061
1.0ml 7.0ml
Concentrate Ready-to-Use
Catalog No.
Size
Format
E18570
0.1ml
Concentrate
E18572
0.5ml
E18574 E18571
Species Reactivity: Human*
Clone: N/A Immunogen: Synthetic peptide derived from N-terminus of human TR-alpha 1 protein. Application: IHC-P Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma
Control Tissue: Thyroid
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Nucleus
Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody E1857
Human Thyroid stained with anti-Thyroid Hormone Receptor alpha1/alpha2 antibody E406
Product Description: Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) during DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS. Over expression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma.
Product Description: Thyroid hormone receptors (TRs) are ligand dependent members of the steroid/retinoic acid superfamily of transcription factors. The two genes encoding TRs identified to date, TRalpha and TRbeta, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half site binding motifs in the orientation of palindromes, direct repeats, or inverted palindromes.
Thymidylate Synthase (TS) Rabbit Polyclonal
Thyroid Hormone Receptor beta Rabbit Polyclonal
Clone: N/A
Catalog No.
Size Format
Clone: N/A
E4070
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to human TS.
E4072
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human TR-beta protein.
1.0ml
Concentrate
Application: IHC-P
E4074
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4071
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E17910
0.1ml
Concentrate
E17912
0.5ml
E17914 E17911
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma
Control Tissue: Thyroid
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Nucleus
Human Colon Carcinoma stained with anti-Thymidylate Synthase (TS) antibody E1791
Human Thyroid stained with anti-Thyroid Hormone Receptor beta antibody E407
Product Description: Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) during DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS. Over expression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma.
Product Description: Thyroid hormone receptors (TRs) are ligand dependent members of the steroid/retinoic acid superfamily of transcription factors. The two genes encoding TRs identified to date, TRalpha and TRbeta, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half site binding motifs in the orientation of palindromes, direct repeats, or inverted palindromes.
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International Orders Email: intlorders@springbio.com
101
Thyroid Stimulating Hormone (TSH) Rabbit Polyclonal
TIMP-2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Purified human TSH.
E4180
0.1ml
Concentrate
Concentrate
Application: IHC-P
E4182
0.5ml
Concentrate
1.0ml
Concentrate
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4184 E4181
1.0ml 7.0ml
Concentrate Ready-to-Use
Catalog No.
Size
Format
E17500
0.1ml
E17502
0.5ml
E17504 E17501
Isotype: Rabbit IgG
Clone: N/A Immunogen: Synthetic peptide derived from N-terminus half of human TIMP-2. Application: IHC-P Species Reactivity: Human* Isotype: Rabbit IgG
Control Tissue: Anterior Pituitary Cellular Localization: Cytoplasm
Control Tissue: Colon Carcinoma
Human Anterior Pituitary stained with anti-Thyroid Stimulating Hormone (TSH) antibody E1750
Human Colon Carcinoma stained with anti-TIMP-2 antibody E418
Cellular Localization: Cytoplasm
Product Description: TSH is a pituitary hormone of 28kDa, which stimulates thyroid growth and production of thyroid hormones. This antibody labels thyrotropic cells of the pituitary.
Product Description: Tissue inhibitor of metalloproteinases-1 and 2 (TIMP-1 and TIMP-2) have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-1 forms a complex with activated interstitial collagenases, stromelysin, and type IV collagenase. TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
TIE-1 Rabbit Polyclonal
TIMP-3 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E3850
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human TIE-1.
E3852
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human TIMP-3.
1.0ml
Concentrate
Application: IHC-P
E3854
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3851
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17520
0.1ml
Concentrate
E17522
0.5ml
E17524 E17521
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Breast Carcinoma, Placenta
Cellular Localization: Membrane
Cellular Localization: Cytoplasm
Human Tonsil stained with anti-TIE-1 antibody E1752
Human Placenta stained with anti-TIMP-3 antibody E385
Product Description: TIE1/TIE (tyrosine kinase with Ig and EGF homology domains 1) and TIE2/Tek are expressed primarily on endothelial and hematopoietic progenitor cells, and play important roles in angiogenesis, vasculogenesis, and hematopoiesis. In developing vascular endothelial cells, TIE1 and TIE2 are specifically expressed. Two ligands that bind TIE have been identified, angiopoietin 1 and angiopoietin 2. The in vivo functions of TIE1 are related to endothelial cell differentiation.
Product Description: TIMPs (Tissue Inhibitors of Metallo Proteinases) form tight inhibitory complexes with MMPs which are involved in matrix degradation and hence, in tumor invasiveness and metastasis. TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
TIMP-1 Rabbit Polyclonal
TNF-R2 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E4320
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from N-terminus half of human TIMP-1.
E4322
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of mouse TNF-R2.
1.0ml
Concentrate
Application: IHC-P
E4324
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4321
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3360
0.1ml
Concentrate
E3362
0.5ml
E3364 E3361
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bladder, Breast, Colon Carcinoma, Ovarian Carcinoma
Control Tissue: Liver Carcinoma, Thymus
Cellular Localization: Cytoplasm
Human Colon Carcinoma stained with anti-TIMP-1 antibody E336
Product Description: Tissue inhibitor of metalloproteinases-1 and 2 (TIMP-1 and TIMP-2) have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-1 forms a complex with activated interstitial collagenases, stromelysin, and type IV collagenase. TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
102
Clone: N/A
Cellular Localization: Cytoplasm
Human Liver Carcinoma stained with anti-TNF-R2 antibody E432
Product Description: Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors. These receptors, designated TNF-R1 and TNF-R2, are 55kDa and 75kDa respectively, and are expressed on most cell types. Signaling through TNF-R2 is confined to cells of the immune system.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Topo II beta Rabbit Polyclonal
TRADD Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E4340
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant of human topoisomerase II beta protein.
E4342
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human TRADD.
1.0ml
Concentrate
Application: IHC-P
E4344
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4341
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4140
0.1ml
Concentrate
E4142
0.5ml
E4144 E4141
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil
Control Tissue: Liver Carcinoma
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm
Human Tonsil stained with anti-Topo II beta antibody E414
Human Liver Carcinoma stained with anti-TRADD antibody E434
Product Description: Topo II beta plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is present ubiquitously in normal cells and is upregulated in tumors and proliferating cells.
Product Description: TRADD (TNF-R1-associated death domain) is an important mediator of FAS and TNF-r1 associated apoptotic signaling. It contains a death domain homologous region (DDH) through which it binds to both FAS and TNF-R1. Overexpression of TRADD causes NFkB activation and apoptosis in absence of TNF.
Topoisomerase I Rabbit Polyclonal
Transforming Growth Factor beta R3 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size Format
Clone: N/A
E11230
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human topoisomerase I protein.
E11232
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E11234
1.0ml
Concentrate
Immunogen: Recombinant human TGF beta Type III receptor protein encoding aa 644-850 expressed in E. coli.
7.0ml
Ready-to-Use
Species Reactivity: Human*
E11231
7.0ml
Ready-to-Use
Application: IHC-P
Catalog No.
Size
Format
E18860
0.1ml
Concentrate
E18862
0.5ml
E18864 E18861
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Placenta
Cellular Localization: Cytoplasm, Nucleus
Cellular Localization: Cytoplasm, Membrane
Human Placenta stained with anti-Transforming Growth Factor beta R3 antibody E1123
Human Breast Carcinoma stained with anti-Topoisomerase I antibody E1886
Product Description: Topoisomerases are nuclear enzymes involved in chromosome condensation, DNA replication, transcription, recombination and segregation during mitosis. Human topoisomerase I is a 100kDa protein capable of relaxing positively and negatively supercoiled DNA by performing a transient single stranded nick. Autoantibodies for both DNA topoisomerases I and II were found to in the sera of patients with certain autoimmune diseases such as systemic lupus erythematosus.
Product Description: A total of three members of the TGF beta family, TGF beta1, TGF beta2 and TGF beta3, have been identified in mammals. The type III TGF beta receptor, also referred to as beta-glycan, confers an additional level of regulation to the TGF beta signaling system by influencing the affinity with which the TGF betas bind to their respective receptors.
Toxoplasma Gondii Rabbit Polyclonal
Transforming Growth Factor beta1 (TGFb1) Rabbit Polyclonal
Catalog No.
Size
Format
Clone: N/A
Catalog No.
Size Format
Clone: N/A
E4520
0.1ml
Concentrate
Immunogen: Toxoplasma gondii.
E11260
0.1ml
Concentrate
E4522
0.5ml
Concentrate
Application: IHC-P
E11262
0.5ml
Concentrate
Immunogen: Recombinant protein located in aa 177-391 of human TGF beta 1.
E4524
1.0ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E11264
E4521
E11261
7.0ml
Ready-to-Use
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Toxoplasma Gondii Infected Tissue
Control Tissue: Placenta
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm, Membrane
Human Placenta stained with anti-Transforming Growth Factor beta1 (TGFb1) antibody E1126
Human Toxoplasma Gondii Infected Brain stained with anti-Toxoplasma Gondii antibody E452
Product Description: Toxoplasma is as an intracellular parasite in various tissues of vertebrates and completes its life cycle in a single host. It is transmitted via raw/ undercooked meat, contaminated soil, or by direct contact. Toxoplasma infects tissue of the GI tract where an active infection is accompanied by fever and enlargement of the spleen. Symptoms of toxoplasmosis are generally mild. However congenital toxoplasmosis can produce blindness or mental retardation in the newborn.
Product Description: A total of three members of the TGF beta family, TGF beta1, TGF beta2 and TGF beta3, have been identified in mammals. TGF betas mediate their activity by high affinity binding to the type II receptor transmembrane protein with a cytoplasmic serine/threonine kinase domain.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
103
Transforming Growth Factor beta2 (TGFb2) Rabbit Polyclonal
Transglutaminase II Rabbit Polyclonal Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E4170
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from internal region of human TGF beta 2.
E4172
0.5ml
Concentrate
Immunogen: Recombinant full length human transglutaminase II protein.
1.0ml
Concentrate
Application: IHC-P
E4174
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4171
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18020
0.1ml
Concentrate
E18022
0.5ml
E18024 E18021
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Extracellular Matrix, Membrane
Human Placenta stained with anti-Transforming Growth Factor beta2 (TGFb2) antibody E1802
Human Breast Carcinoma stained with anti-Transglutaminase II antibody E417
Product Description: Transforming growth factor betas (TGFbs) mediate many cell-cell interactions that occur during embryonic development. Three TGFbs (TGFb1, TGFb2 and TGFb3) have been identified in mammals. They are synthesized as precursor proteins and then cleaved to yield a 112 amino acid polypeptide. This antibody reacts with the precursor and mature form of TGFb2 and to a lesser extent TGF3, but does not cross react with TGFb1.
Product Description: TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
Transforming Growth Factor beta3 (TGFb3) Rabbit Polyclonal
TTF-1 Rabbit Polyclonal Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E19180
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of the precursor form of human TGF beta 3.
E19182
0.5ml
Concentrate
Immunogen: Synthetic peptide in the internal region of human TTF-1 protein.
1.0ml
Concentrate
Application: IHC-P
E19184
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E19181
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3940
0.1ml
Concentrate
E3942
0.5ml
E3944 E3941
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta
Control Tissue: Lung, Lung Adenocarcinoma, Thyroid
Cellular Localization: Cytoplasm
Cellular Localization: Nucleus Control Lysate: HeLa Molecular Weight: 39 kDa
Human Placenta stained with anti-Transforming Growth Factor beta3 (TGFb3) antibody E394
Human Thyroid stained with anti-TTF-1 antibody E1918
Product Description: A total of three members of the TGF beta family, TGF beta1, TGF beta2 and TGF beta3, have been identified in mammals. The type III TGF beta receptor, also referred to as beta-glycan, confers an additional level of regulation to the TGF beta signaling system by influencing the affinity with which the TGF betas bind to their respective receptors.
Product Description: Thyroid transcription factor-1 (TTF-1) is a member of the NKx2 family of homeodomain transcription factors. It binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. TTF-1 is important in the maintenance of thyroid differentiation and lung development. It is expressed in epithelial cells of the thyroid gland and the lung, and tumors derived from such epithelial cells.
Transforming Growth Factor R1 Rabbit Polyclonal
TTF-1 Mouse Monoclonal
Catalog No.
Size
Format
E12340
0.1ml
Concentrate
E12342
0.5ml
Concentrate
E12344 E12341
1.0ml 7.0ml
Concentrate Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to internal region of human TGF beta R1.
E17080
0.1ml
Concentrate
Immunogen: Rat TTF-1 recombinant protein.
E17082
0.5ml
Concentrate
Application: IHC-P
Application: IHC-P
E17084
1.0ml
Concentrate
Species Reactivity: Human*
E17081
7.0ml
Ready-to-Use
Species Reactivity: Human*
Isotype: Rabbit IgG Control Tissue: Placenta Cellular Localization: Membrane
Human Placenta stained with anti-Transforming Growth Factor R1 antibody E1234
Product Description: A total of three members of the TGF beta family, TGF beta1, TGF beta2 and TGF beta3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFbetas mediate their activity by high affinity binding to the type II receptor 70kDa transmembrane protein with a cytoplasmic serine/ threonine kinase domain.
104
Clone: 8G7G3/1
Isotype: Mouse IgG1/k Control Tissue: Lung, Thyroid Cellular Localization: Nucleus
Human Lung stained with anti-TTF-1 antibody E1708
Product Description: TTF-1 (Thyroid transcription factor-1) is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. TTF-1 is detected in primary lung adenocarcinomas and small cell carcinomas and is absent in colon and breast carcinomas.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Tubulin-alpha Rabbit Polyclonal
Ubiquitin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3350
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human tubulin alpha.
E3352
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
E3354 E3351
1.0ml 7.0ml
Concentrate Ready-to-Use
Catalog No.
Size
Format
E4130
0.1ml
Concentrate
E4132
0.5ml
E4134 E4131
Species Reactivity: Human*
Clone: N/A Immunogen: Recombinant full length human ubiquitin protein. Application: IHC-P Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung
Control Tissue: Alzheimer’s Brain, Pancreas
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane, Nucleus
Human Lung stained with anti-Tubulin-alpha antibody E413
Human Alzheimer’s Brain stained with anti-Ubiquitin antibody E335
Product Description: Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of tubulin, which is a dimer of two 55kDa subunits: alpha and beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton.
Product Description: Ubiquitin (Ub) plays a very important role in regulated nonlysosomal ATP dependent protein degradation. The protein to be degraded is conjugated to Ub and the ubiquinated protein is then selectively degraded by a 26S complex, multicatalytic cytosolic and nuclear protease termed proteasome. The Ub-proteasome proteolytic pathway, which is a complex process, is implicated to be of great importance for regulating numerous cellular processes.
Tubulin-beta Rabbit Polyclonal
Urocortin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size Format
Clone: N/A
E4480
0.1ml
Concentrate
E4482
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of urocortin.
Catalog No.
Size
Format
E3810
0.1ml
Concentrate
E3812
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human tubulin beta.
E3814
1.0ml
Concentrate
Application: IHC-P
E4484
1.0ml
Concentrate
Application: IHC-P
E3811
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4481
7.0ml
Ready-to-Use
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung, Skin
Control Tissue: Pituitary
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm
Human Lung stained with anti-Tubulin-beta antibody E381
Human Pituitary stained with anti-Urocortin antibody E448
Product Description: Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of tubulin, which is a dimer of two 55kDa subunits: alpha and beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. This antibody blocks (by 70-80%) the ability of tubulin dimers (with GppNHp bound) to promote a stable inhibition of adenylyl cyclase.
Product Description: Urocortin (UCN), a neuropeptide widely distributed in the central nervous system (CNS), belongs to a family of structurally related peptides including corticotrophin releasing factor (CRF), sauvagine and urotensin I. Urocortin is derived from a larger precursor protein (pro-urocortin). Urocortin has biological actions similar to CRF. It is a potent stimulator of adrenocorticotropic hormone (ACTH) secretion by corticotroph cells from the anterior pituitary.
Tubulin-gamma Rabbit Polyclonal
Uroplakin III Rabbit Monoclonal
Clone: N/A
Catalog No.
Size Format
Clone: SP73
M3730
0.1ml
Concentrate
M3732
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human uroplakin III protein.
Catalog No.
Size
Format
E10330
0.1ml
Concentrate
E10332
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human tubulin gamma protein.
E10334
1.0ml
Concentrate
Application: IHC-P
M3734
1.0ml
Concentrate
Application: IHC-P
E10331
7.0ml
Ready-to-Use
Species Reactivity: Human*
M3731
7.0ml
Ready-to-Use
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma
Control Tissue: Bladder, Bladder Carcinoma
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Human Colon Carcinoma stained with anti-Tubulin-gamma antibody E1033
Human Bladder Carcinoma stained with anti-Uroplakin III antibody M373
Product Description: Tubulin gamma, an essential structural protein for cell growth, organizes microtubule arrays in the nucleus and cytoplasm. Tubulin gamma-depleted cells fail to form functional spindles and arrest during nuclear division. Tubulin gamma associates with spindle body components Spc97 and Spc98 to form the tubulin gamma complex. The phosphorylation of tubulin gamma at Tyr445 plays a regulatory role in microtubule formation.
Product Description: Uroplakins are specific differentiation products of terminally differentiated superficial urothelial cells. Uroplakin III is expressed in primary and metastatic urothelial carcinomas.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
105
Uroplakin III Rabbit Polyclonal Catalog No.
Size
Format
E18240
0.1ml
Concentrate
E18242
0.5ml
Concentrate
E18244
1.0ml
Concentrate
E18241
7.0ml
Ready-to-Use
Vascular Endothelial Growth Factor (VEGF) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide corresponding to C-terminus of human uroplakin III.
E2610
0.1ml
Concentrate
E2612
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human VEGF.
E2614
1.0ml
Concentrate
Application: IHC-P, WB
Application: IHC-P
E2611
7.0ml
Ready-to-Use
Species Reactivity: Human*
Clone: N/A
Species Reactivity: Human* Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Angiosarcoma
Control Tissue: Bladder, Bladder Carcinoma
Cellular Localization: Cytoplasm, Extracellular Matrix, Membrane
Cellular Localization: Cytoplasm, Membrane Control Lysate: Human Bladder Molecular Weight: 32 kDa
Human Angiosarcoma stained with anti-Vascular Endothelial Growth Factor (VEGF) antibody E261
Human Bladder Carcinoma stained with anti-Uroplakin III antibody E1824
Product Description: Uroplakins are specific differentiation products of terminally differentiated superficial urothelial cells. Uroplakin III is expressed in primary and metastatic urothelial carcinomas.
Product Description: VEGF (Vascular Endothelial Growth Factor) is a homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. This antibody reacts with the 165, 189 and 121 amino acid splice variants of human VEGF.
USF-2 Rabbit Polyclonal
Villin Rabbit Polyclonal Clone: N/A
Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Synthetic peptide corresponding to aa 327-346 of mouse USF-2.
E16640 E16642
0.1ml 0.5ml
Concentrate Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human villin.
1.0ml
Concentrate
Application: IHC-P
E16644
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E16641
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12560
0.1ml
Concentrate
E12562
0.5ml
E12564 E12561
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Tissue: Small Intestine
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm, Membrane
Human Breast Carcinoma stained with anti-USF-2 antibody E1256
Human Small Intestine stained with anti-Villin antibody E1664
Product Description: The ubiquitously expressed cellular upstream stimulatory factor (USF) consists of 43kDa (USF-1) and 44kDa (USF-2) polypeptides which independently exhibit site-specific DNA binding and are members of the c-Myc-related family of regulatory factors containing helix-loop-helix domains. USF also contains a leucine repeat that is required for efficient DNA binding.
Product Description: Villin is an actin binding protein expressed mainly in the brush border of the epithelium in vertebrates. Villin can cap, nucleate, sever and bundle actin in a Ca2+ and phosphoinositide-regulated manner. Villin is composed of six repeats that together constitute the core domain. The core domain retains the Ca2+ dependent capping nucleating and severing activity, whereas the headpiece domain contributes towards actin filament bundling and binding F-actin.
Vascular Endothelial Growth Factor (VEGF) Rabbit Monoclonal
Vimentin Rabbit Monoclonal
Catalog No.
Size
Format
N/A
N/A
N/A
N/A
N/A
N/A
N/A M3281
N/A 7.0ml
N/A Ready-to-Use
Clone: SP28
Catalog No.
Size
Format
Immunogen: Synthetic peptide derived from N-terminus of human VEGF.
M3200
0.1ml
Concentrate
Clone: SP20
M3202
0.5ml
Concentrate
Immunogen: Recombinant human vimentin protein.
Application: IHC-P
M3204
1.0ml
Concentrate
Application: IHC-P, WB
Species Reactivity: Human*
M3201
7.0ml
Ready-to-Use
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Angiosarcoma
Control Tissue: Melanoma, Sarcomas
Cellular Localization: Cytoplasm, Extracellular Matrix, Membrane
Cellular Localization: Cytoplasm Control Lysate: HeLa Molecular Weight: 53 kDa
Human Angiosarcoma stained with anti-Vascular Endothelial Growth Factor (VEGF) antibody M328
Product Description: VEGF (Vascular Endothelial Growth Factor) is a homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. This antibody reacts with the 165, 189 and 121 amino acid splice variants of human VEGF.
106
Human Melanoma stained with anti-Vimentin antibody M320
Product Description: Vimentin is the main intermediate filament protein in mesenchymal cells. This protein is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin is expressed in sarcomas of neural, muscle and fibroblast origin, but carcinomas are generally negative. Melanomas, lymphomas and vascular tumors may express vimentin.
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies Vinculin Rabbit Monoclonal
WNT-1 Rabbit Polyclonal Clone: SP117
Catalog No.
Size
Format
E3960
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human vinculin protein.
E3962
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from N-terminus of human WNT-1.
1.0ml
Concentrate
Application: IHC-P
E3964
1.0ml
Concentrate
Application: IHC-P, WB
7.0ml
Ready-to-Use
Species Reactivity: Human*
E3961
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4170
0.1ml
Concentrate
M4172
0.5ml
M4174 M4171
Clone: N/A
Species Reactivity: Human*
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Heart, Small Intestine
Control Tissue: Breast Carcinoma
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm Control Lysate: NIH3T3 Molecular Weight: 42 kDa Human Breast Carcinoma stained with anti-WNT-1 antibody E396
Human Heart stained with anti-Vinculin antibody M417
Product Description: Vinculin is a muscle-specific cytoskeletal protein associated with the cytoplasmic faces of both cell-cell and cell extracellular matrix adherens type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane and regulating cell-surface E-cadherin expression. The defect of this protein can cause dilated cardiomyopathy
Product Description: Wnt-1 is a cysteine-rich secreted glycoprotein that associates with cell membranes and likely functions as a key regulator of cellular adhesion. Wnt-1 is essential for normal development of the embryonic nervous system and its expression is normally limited to the embryonic neural tube and adult spermatids.
Vinculin Rabbit Polyclonal
XMRV Rabbit Polyclonal Clone: N/A
Catalog No.
Size Format
Clone: N/A
E19070
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from C-terminus of human vinculin protein.
E19072
0.5ml
Concentrate
Immunogen: Synthetic peptide near N-terminus of XMRV envelope protein.
1.0ml
Concentrate
Application: IHC-P
E19074
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E19071
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E18720
0.1ml
Concentrate
E18722
0.5ml
E18724 E18721
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Pancreas, Small Intestine
Control Tissue: Prostate Carcinoma with XMRV Infection
Cellular Localization: Cytoplasm
Cellular Localization: Cytoplasm, Membrane
Human Pancreas stained with anti-Vinculin antibody E1872
Human Prostate Carcinoma with XMRV Infection stained with anti-XMRV antibody E1907
Product Description: Vinculin is a cytoskeletal protein associated with the cytoplasmic faces of both cell-cell and cell extracellular matrix adherens type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. Vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system.
Product Description: Xenotropic murine leukemia virus-related virus (XMRV) is a newly recognized human retrovirus first identified in prostate cancer tissues from men with a deficiency in the innate immunity gene RNASEL. At present, studies have detected XMRV DNA and protein in prostate cancer at widely different rates and in patients with chronic fatigue syndrome. The XMRV protein is synthesized in the Golgi by host cells.
Wilm’s Tumor (WT) Rabbit Polyclonal
XRCC2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size Format
Clone: N/A
E4010
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of human Wilm’s tumor protein.
E4012
0.5ml
Concentrate
Immunogen: Synthetic peptide from N-terminus of human XRCC2.
1.0ml
Concentrate
Application: IHC-P
E4014
1.0ml
Concentrate
Application: IHC-P
7.0ml
Ready-to-Use
Species Reactivity: Human*
E4011
7.0ml
Ready-to-Use
Species Reactivity: Human*
Catalog No.
Size
Format
E3990
0.1ml
Concentrate
E3992
0.5ml
E3994 E3991
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Wilm’s Tumor
Control Tissue: Testis
Cellular Localization: Nucleus
Cellular Localization: Cytoplasm, Nucleus
Human Wilm’s Tumor stained with anti-Wilm’s Tumor (WT) antibody E399
Human Testis stained with anti-XRCC2 antibody E401
Product Description: Wilm’s tumor (WT), a sporadic and familial childhood kidney tumor, is genetically heterogeneous. Wilm’s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelioma.
Product Description: XRCC2 (X-Ray Cross Complementing 2) is essential for repairing the double strand DNA breaks by homologous recombination between sister chromatids. It is homologous to Rad51. Five human homologues of RAD 51; XRCC2, XRCC3, RAD51B, RAD51C, RAD51D, interact among themselves to form one big complex or several smaller complexes.
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
International Orders Email: intlorders@springbio.com
107
ZAP-70 Rabbit Polyclonal Catalog No.
Size
Format
E12520
0.1ml
Concentrate
E12522
0.5ml
Concentrate
E12524
1.0ml
Concentrate
E12521
7.0ml
Ready-to-Use
Clone: N/A Immunogen: Synthetic peptide corresponding to C-terminus of human ZAP-70. Application: IHC-P, WB Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Tonsil Cellular Localization: Cytoplasm Control Lysate: Jurkat Molecular Weight: 70 kDa Human Tonsil stained with anti-ZAP-70 antibody E1252
Product Description: Mutations in ZAP-70 gene results in a form of Severe Combined Immunodeficiency Syndrome (SCID) in humans. ZAP-70 is also expressed in a subset of Chronic Lymphocytic Leukemia (CLL).
ZO-3 Rabbit Polyclonal Clone: N/A
Catalog No.
Size
Format
E17450
0.1ml
Concentrate
E17452
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to C-terminus of human ZO-3.
E17454
1.0ml
Concentrate
Application: IHC-P
E17451
7.0ml
Ready-to-Use
Species Reactivity: Human* Isotype: Rabbit IgG Control Tissue: Small Intestine Cellular Localization: Membrane
Human Small Intestine stained with anti-ZO-3 antibody E1745
Product Description: Tight junctions are complexes of proteins between the plasma membrane domains of epithelial and endothelial cells. ZO-3 forms complexes with ZO-1 and interacts with occludin and claudins. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue.
108
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting *Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details. **Product available to direct customers and Spring-appointed distributors only.
D E T E C T I O N A N D A N C I L L A RY P R O D U C T S
Spring Bioscience offers a complete line of detection systems optimized for immunohistochemistry (IHC) and are designed to meet the complex needs of any laboratory. Featuring: • Improved signal to noise ratios • Shorter incubation times • Works with mouse and rabbit primary antibodies • Clean and crisp staining
REVEAL™ Detection Systems – novel biotin-free chemistries enable our best-in-class detection systems, including: • REVEAL HRP DAB System • REVEAL HRP AEC System • REVEAL AP Red System
REVEAL™ Best-in-Class Detection Systems Spring Bioscience’s novel biotin-free detection system, REVEAL™, eliminates the polymer backbone and allows the enzyme to be conjugated directly to the secondary antibody by long-arm linkers. The compact size of the molecule enables diffusion through tissue promoting access to targeted binding sites.
p53 (SP5) Cat# M3054, Colon Adenocarcinoma
p53 (SP5) Cat #M3054, Colon Carcinoma
REVEAL AP Conjugate
REVEAL HRP Conjugate
Leading Competitor’s AP Conjugate
Leading Competitor’s HRP Polymer
Spring REVEAL Biotin-Free Detection Systems Catalog Number
110
Product Name
Size
Format
15ml
Ready-to-use
SPA-015
Reveal - Biotin-Free Polyvalent AEC
SPA-060
Reveal - Biotin-Free Polyvalent AEC
60ml
Ready-to-use
SPA-125
Reveal - Biotin-Free Polyvalent AEC
125ml
Ready-to-use
SPD-015
Reveal - Biotin-Free Polyvalent DAB
15ml
Ready-to-use
SPD-060
Reveal - Biotin-Free Polyvalent DAB
60ml
Ready-to-use
SPD-125
Reveal - Biotin-Free Polyvalent DAB
125ml
Ready-to-use
PAR-015
Reveal - Biotin-Free Polyvalent AP (Red)
15ml
Ready-to-use
PAR-060
Reveal - Biotin-Free Polyvalent AP (Red)
60ml
Ready-to-use
PAR-125
Reveal - Biotin-Free Polyvalent AP (Red)
125ml
Ready-to-use
SRA-015
Reveal - Rabbit-Specific AEC
15ml
Ready-to-use
SRA-060
Reveal - Rabbit-Specific AEC
60ml
Ready-to-use
SRA-125
Reveal - Rabbit-Specific AEC
125ml
Ready-to-use
SRD-015
Reveal - Rabbit-Specific DAB
15ml
Ready-to-use
SRD-060
Reveal - Rabbit-Specific DAB
60ml
Ready-to-use
SRD-125
Reveal - Rabbit-Specific DAB
125ml
Ready-to-use
RAR-015
Reveal - Rabbit Specific AP (Red)
15ml
Ready-to-use
RAR-060
Reveal - Rabbit Specific AP (Red)
60ml
Ready-to-use
RAR-125
Reveal - Rabbit Specific AP (Red)
125ml
Ready-to-use
MAR-015
Reveal - Mouse Specific AP (Red)
15ml
Ready-to-use
MAR-060
Reveal - Mouse Specific AP (Red)
60ml
Ready-to-use
MAR-125
Reveal - Mouse Specific AP (Red)
125ml
Ready-to-use
SPB-999
Reveal - Polyvalent HRP
1000ml
Ready-to-use
Spring Bioscience offers a complete line of detection systems optimized for immunohistochemistry (IHC) and are designed to meet the complex needs of any laboratory.
Detection and Ancillary Products Biotin-Streptavidin Detection Systems Catalog Number
Product Name
Size
Format
TPA-015
Polyvalent HRP AEC Detection System
15ml
Ready-to-use
TPD-015
Polyvalent HRP DAB Detection System
15ml
Ready-to-use
TRA-015
Anti-rabbit HRP AEC Detection System
15ml
Ready-to-use
TRD-015
Anti-rabbit HRP DAB Detection System
15ml
Ready-to-use
TMA-015
Anti-mouse HRP AEC Detection System
15ml
Ready-to-use
TMD-015
Anti-mouse HRP DAB Detection System
15ml
Ready-to-use
HRP-060
Polyvalent HRP Kit
60ml
Ready-to-use
HRP-125
Polyvalent HRP Kit
125ml
Ready-to-use
HRP-999
Polyvalent HRP Kit
1000ml
Ready-to-use
UVX-060
Polyvalent HRP Plus Kit
60ml
Ready-to-use
UVX-125
Polyvalent HRP Plus Kit
125ml
Ready-to-use
UVP-060
Polyvalent Alk Phos Kit
60ml
Ready-to-use
UVP-125
Polyvalent Alk Phos Kit
125ml
Ready-to-use
Size
Format
Detection Components Catalog Number
Product Name
DGP-125
Biotinylated Goat Polyvalent IgG's
125ml
Ready-to-use
DGP-999
Biotinylated Goat Polyvalent IgG's
1000ml
Ready-to-use
DGR-125
Biotinylated Goat anti-Rabbit IgG's
125ml
Ready-to-use
DGM-125
Biotinylated Goat anti-Mouse IgG's
125ml
Ready-to-use
DSA-125
Streptavidin Alkaline Phosphatase
125ml
Ready-to-use
DSP-125
Streptavidin Horseradish Peroxidase
125ml
Ready-to-use
DSP-999
Streptavidin Horseradish Peroxidase
1000ml
Ready-to-use
Diluent/Buffers/Miscellaneous Catalog Number
Product Name
Size
Format
125ml
Ready-to-use
ADS-125
Antibody Diluent
PBS-125
PBS (25x) pH 7.6
125ml
Concentrate
PBS-999
PBS (25x) pH 7.6
1000ml
Concentrate
PBT-125
PBS with Tween 20 (20x)
125ml
Concentrate
PBT-999
PBS with Tween 20 (20x)
1000ml
Concentrate
TBS-125
TBS (25x), pH7.4
125ml
Concentrate
TBS-999
TBS (25x), pH7.4
1000ml
Concentrate
TBT-125
TBS with Tween 20 (20x)
125ml
Concentrate
TBT-999
TBS with Tween 20 (20x)
1000ml
Concentrate
DMM-060
Mounting Media
60ml
Ready-to-use
DMM-125
Mounting Media
125ml
Ready-to-use
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111
Epitope Recovery/Pretreatment Products Catalog Number
Product Name
Size
Format
PMB1-125
Antigen Retrieval Buffer 1 (100x) pH=6.0
125ml
Concentrate
PMB1-250
Antigen Retrieval Buffer 1 (100x) pH=6.0
250ml
Concentrate
PMB2-125
Antigen Retrieval Buffer 2 (100x) pH=8.0
125ml
Concentrate
PMB2-250
Antigen Retrieval Buffer 2 (100x) pH=8.0
250ml
Concentrate
PMB3-125
Antigen Retrieval Buffer 3 (100x) pH=10.0
125ml
Concentrate
PMB3-250
Antigen Retrieval Buffer 3 (100x) pH=10.0
250ml
Concentrate
PMB4-125
Antigen Retrieval Buffer 4 (100x) pH=9.0
125ml
Concentrate
PMB4-250
Antigen Retrieval Buffer 4 (100x) pH=9.0
250ml
Concentrate
DCB-125
Citrate Buffer (10x) pH 6.0
125ml
Concentrate
DCBX-050
Citrate Buffer (100x) pH 6.0
50ml
Concentrate
DEB-125
EDTA Buffer (10x) pH 8.0
125ml
Concentrate
DEBX-050
EDTA Buffer (100x) pH 8.0
50ml
Concentrate
DTB-125
Tris Buffer (10x) pH 10.0
125ml
Concentrate
DTBX-050
Tris Buffer (100x) pH 10.0
50ml
Concentrate
DTS-007
Trypsin (2 components)
7ml
Concentrate
DPS-007
Pepsin
7ml
Ready-to-use
PRK-004
Proteinase K
4ml
Ready-to-use
Blocking Reagents Catalog Number
Product Name
Size
Format
DHP-060
Hydrogen Peroxide Block
60ml
Ready-to-use
DHP-125
Hydrogen Peroxide Block
125ml
Ready-to-use
DPB-060
Protein Block
60ml
Ready-to-use
DPB-125
Protein Block
125ml
Ready-to-use
BRB-050
Background Reducing Buffer
50ml
Ready-to-use
DBB-015
Avidin/Biotin Blocking System (2 components)
15ml
Ready-to-use
Size
Format
Chromogens Catalog Number
112
Product Name
ASS-060
AEC Single Solution
60ml
Ready-to-use
ASS-125
AEC Single Solution
125ml
Ready-to-use
DAB-060
DAB (2 components, 50x)
60ml
Concentrate
DAB-125
DAB (2 components, 50x)
125ml
Concentrate
DAB-999
DAB (2 components, 50x)
1000ml
Concentrate
DABD-999
DAB (2 components, 25X)
1000ml
Concentrate
LFR-060
Liquid Fast Red Substrate System (75x)
60ml
Concentrate
LFR-125
Liquid Fast Red Substrate System (75x)
125ml
Concentrate
LFR-999
Liquid Fast Red Substrate System (75x)
1000ml
Concentrate
LFRD-999
Liquid Fast Red Substrate System (25x)
1000ml
Concentrate
A N T I B O D Y M I C R O A R R AY P R O D U C T S
Antibody microarrays provide researchers the convenience of detecting and analyzing multiple proteins simultaneously on a single slide. Formats Include: • Master Array (650+ antibodies) •
Arrays by Pathway (Angiogenesis, Apoptosis, Cancer Marker, Cell Cycle, Cytokine Array, Hematopoiesis, Hormone, Signal Transduction, and Stem Cell)
Research Applications Include: • Protein expression profiling • Comparison profiles of normal, diseased, or treated samples • Identification of candidate biomarkers Researcher Benefits Include: • Time savings • Reduction in reagent costs • Reduced variability • Flexible sample preparations (cell extracts, tissue lysates, treated samples) • Built-in control
Array Options to Meet Your Varied Research Interests Antibody microarrays provide a high-throughput platform for sensitive, efficient and accurate protein expression profiling, screening and comparison between normal and diseased or treated samples. Proteins from cell extracts, tissue lysates or treated samples may be used for analysis and detection. Antibody microarrays enable the qualitative measurement of protein expression. Spring’s Master Antibody Microarray kit consists of a set of two slides containing over 650 antibodies printed in duplicate. These high affinity antibodies are well characterized for immunohistochemistry or Western blot. Spring’s antibody microarrays by pathway are designed for researchers interested in a specific field such as cancer markers. Each pathway microarray kit contains two identical subarrays (one subarray for normal sample and another for the treated sample). Each subarray contains 6 replicates of each antibody. Positive and negative controls are included on each subarray. New Master Array coming in 2012!
Microarray Products Catalog Number
114
Product Name
Size
AMD-001
Antibody Microarray Detection Kit
AMS-700
Master Antibody Microarray Slides (656 Abs)
2 slides
1 kit
AAG-100
Angiogenesis Microarray Slides (127 Abs)
2 slides
AAP-100
Apoptosis Microarray Slides (71 Abs)
2 slides
ACC-100
Cell Cycle Microarray Slides (60 Abs)
2 slides
ACK-100
Cytokine Microarray Slides (77 Abs)
2 slides
ACM-100
Cancer Marker Microarray Slides (86 Abs)
2 slides
AHM-100
Hormone Microarray Slides (30 Abs)
2 slides
AHP-100
Hematopoiesis Microarray Slides (50 Abs)
2 slides
ASC-100
Stem Cell Microarray Slides (58 Abs)
2 slides
AST-100
Signal Transduction Microarray Slides (165 Abs)
2 slides
Antibody microarrays provide researchers the convenience of detecting and analyzing multiple proteins simultaneously on a single slide.
RECOMBINANT PROTEIN PRODUCTS
Recombinant proteins – expressed in E. coli and are: • Full length or partial sequence of specific proteins • Fused at N-terminus with GST/His-tag • Analyzed by SDS-PAGE using coomassie Blue staining • Available in 0.1ml (0.1mg/ml) size
116
Catalog Number
Product Name
Domain
P1094
ALK/p80
aa 426-528
P7014
BCL-6
aa 1-150
P3464
Cadherin E
aa 600-707
P1174
Calretinin
full length
P2824
Cathepsin D
full length
P3044
CD2
aa 25-209
P7044
CD4
aa 26-226
P7979
CD4
aa 207-316
P3024
CD23
aa 48-248
P7122
CD34
full length
P7054
CD68
full length
P3394
CD99
full length
P7982
CD138
aa 18-218
P2444
c-erbB2
aa 537-636
P1524
Chromogranin A
aa 260-454
P7978
c-Met
aa 18-217
P2434
D4GDI
full length
P1644
ER alpha
aa 1-300
P7977
ERCC1
full length
P3644
FHIT
full length
P7127
gp100
aa 1-150
P7113
GST
full length
P7513
IGF-1R
aa 1213-1367
P7861
Involucrin
aa 420-578
P7126
IRF4/MUM1
aa 144-451
P3264
Keratin 8
full length
P7514
LYVE-1
aa 243-323
P7120
MAGE-1
full length
P7522
NY-ESO-1
full length
P7074
p53 mutant (aa135)
full length
P2014
p53 wild type
full length
P2854
PCNA
full length
P3344
PGP9.5
full length
P7125
PPAR gamma
aa 1-477
P2074
Progesterone Receptor (PR)
aa 412-562
P7935
PSMA
aa 1-150
P7094
PTEN
full length
P2144
S100 beta
full length
P7121
S100A4
full length
P7914
SOX9
aa 1-150
P7874
TGF beta1
aa 177-391
P3354
Ubiquitin
full length
P2944
Vimentin
full length
Product Index
RbMab – SP Clones Actin-beta Rabbit Monoclonal 12 ALK/p80 Rabbit Monoclonal 14 Androgen Receptor (AR) Rabbit Monoclonal 15 BAX Rabbit Monoclonal 16 BCL-2 alpha Rabbit Monoclonal 16 BOB-1 Rabbit Monoclonal 18 C4d Rabbit Monoclonal 19 Cadherin-E/E-Cadherin Rabbit Monoclonal 19 Cadherin-N/N-Cadherin Rabbit Monoclonal 20 Calcitonin Rabbit Monoclonal 20 Calpain Rabbit Monoclonal 21 Calpastatin Rabbit Monoclonal 21 Calretinin Rabbit Monoclonal 22 Carbonic Anhydrase 9 (CA-9) Rabbit Monoclonal 22 Caveolin-1 Rabbit Monoclonal 24 CD3 Rabbit Monoclonal 25 CD4 Rabbit Monoclonal 26 CD5 Rabbit Monoclonal 26 CD7 Rabbit Monoclonal 26 CD8 Rabbit Monoclonal 27 CD10 Rabbit Monoclonal 27 CD19 Rabbit Monoclonal 27 CD20 Rabbit Monoclonal 28 CD22 Rabbit Monoclonal 28 CD23 Rabbit Monoclonal 28 CD31 Rabbit Monoclonal 29 CD43 Rabbit Monoclonal 30 CD44 Std Rabbit Monoclonal 30 CD79a Rabbit Monoclonal 32 CD99 Rabbit Monoclonal 33 CD117/c-kit Rabbit Monoclonal 33 CD163 Rabbit Monoclonal 34 CD278/ICOS Rabbit Monoclonal 35
Ki-67 Rabbit Monoclonal 66 LMO2 Rabbit Monoclonal 68 MCM2 Rabbit Monoclonal 69 Mesothelin Rabbit Monoclonal 71 MSH2 Rabbit Monoclonal 73 MSH6 Rabbit Monoclonal 74 MUM1/IRF4 Rabbit Monoclonal 76 Myeloperoxidase (MPO) Rabbit Monoclonal 76 Nestin Rabbit Monoclonal 77 Nitric Oxide Synthase-Inducible (iNOS) Rabbit Monoclonal 78 p120 (catenin delta 1) Rabbit Monoclonal 80 p53 Rabbit Monoclonal 81 p57 Rabbit Monoclonal 81 PAX-5 Rabbit Monoclonal 83 PI3K p85 Rabbit Monoclonal 85 PLAP Rabbit Monoclonal 86 Progesterone Receptor (PR) Rabbit Monoclonal 88 Progesterone Receptor (PR) Rabbit Monoclonal 88 PSMA Rabbit Monoclonal 90 S6 Ribosomal (Phospho S235/236) Rabbit Monoclonal 93 S6 Ribosomal (Phospho S240/244) Rabbit Monoclonal 93 SLIT2 Rabbit Monoclonal 94 SOX-2 Rabbit Monoclonal 96 Stathmin Rabbit Monoclonal 98 Survivin Rabbit Monoclonal 98 Synaptophysin Rabbit Monoclonal 99 Syntaxin 1A Rabbit Monoclonal 99 Tau (Neuronal Marker) Rabbit Monoclonal 100 Thymidylate Synthase (TS) Rabbit Monoclonal 101 Uroplakin III Rabbit Monoclonal 105 Vascular Endothelial Growth Factor (VEGF) Rabbit Monoclonal 106 Vimentin Rabbit Monoclonal 106 Vinculin Rabbit Monoclonal 107
CDK2 Rabbit Monoclonal 35 CDX2 Rabbit Monoclonal 36 c-erbB-2/HER-2 Rabbit Monoclonal 37 c-erbB-3/HER-3 Rabbit Monoclonal 37 Chromogranin A Rabbit Monoclonal 38 c-Met Rabbit Monoclonal 40 c-Met (Paired 1003) Rabbit Monoclonal 40 c-Met (Phospho Y1003) Rabbit Monoclonal 40 COX-2 Rabbit Monoclonal 42 c-TEN Rabbit Monoclonal 42 Cyclin D1 Rabbit Monoclonal 43 DOG-1 Rabbit Monoclonal 45 Epidermal Growth Factor Receptor (EGFR) Rabbit Monoclonal 47 Epidermal Growth Factor Receptor (EGFR) Rabbit Monoclonal 47 ERCC1 Rabbit Monoclonal 48 Estrogen Receptor (ER) Rabbit Monoclonal 49 F4/80 Rabbit Monoclonal 49 FLK-1 (mouse) Rabbit Monoclonal 51 FOXA1 Rabbit Monoclonal 52 FOXP3 Rabbit Monoclonal 53 Glial Fibrillary Acidic Protein (GFAP) Rabbit Monoclonal 54 Glypican-3 Rabbit Monoclonal 56 hENT1 Rabbit Monoclonal 59 IKAROS Rabbit Monoclonal 60 J-chain Rabbit Monoclonal 62 Keratin 5 Rabbit Monoclonal 62 Keratin 6 Rabbit Monoclonal 63 Keratin 7 Rabbit Monoclonal 63 Keratin 8 Rabbit Monoclonal 63 Keratin 10 Rabbit Monoclonal 64 Keratin 14 Rabbit Monoclonal 64 Keratin 17 Rabbit Monoclonal 64 Keratin 18 Rabbit Monoclonal 65 Keratin 20 Rabbit Monoclonal 66
14-3-3 beta Rabbit Polyclonal 12 14-3-3 zeta Rabbit Polyclonal 12
Annexin VI Rabbit Polyclonal 16 Apoptosis Protease Activating Factor 1 (APAF-1) Rabbit Polyclonal 16
A
B
Actin-beta Rabbit Monoclonal 12 Actin-beta Rabbit Polyclonal 12 Actin-Skeletal Muscle Rabbit Polyclonal 12 Actin-Skeletal Muscle Mouse Monoclonal 12 Actin-Smooth Muscle Rabbit Polyclonal 13 Actin-Smooth Muscle Mouse Monoclonal 13 Adenomatous Polyposis Coli (APC) Rabbit Polyclonal 13 Adrenocorticotrophic Hormone (ACTH) Rabbit Polyclonal 13 Adrenocorticotrophic Hormone (ACTH) Mouse Monoclonal 13 AKT-1/AKT-2 Rabbit Polyclonal 13 AKT-1/PKB (Phospho S473) Rabbit Polyclonal 14 ALK/p80 Rabbit Monoclonal 14 ALK/p80 Rabbit Polyclonal 14 alpha Fetoprotein (AFP) Rabbit Polyclonal 14 alpha-1-Antichymotrypsin Rabbit Polyclonal 14 alpha-1-Antitrypsin Rabbit Polyclonal 14 Amylin Peptide Rabbit Polyclonal 15 Amyloid Precursor Protein (APP) Rabbit Polyclonal 15 Amyloid-beta/Amyloid A4 Rabbit Polyclonal 15 Androgen Receptor (AR) Rabbit Monoclonal 15 Androgen Receptor (AR) Rabbit Polyclonal 15 Annexin I Rabbit Polyclonal 15
BAK Rabbit Polyclonal 16 BAX Rabbit Monoclonal 16 BAX Rabbit Polyclonal 16 BCL-2 alpha Rabbit Monoclonal 16 BCL-2 alpha Rabbit Polyclonal 17 BCL-6 Rabbit Polyclonal 17 BCL-10 Rabbit Polyclonal 17 BCL-10 Rabbit Polyclonal 17 BCL-10 Mouse Monoclonal 17 BCL-X Rabbit Polyclonal 17 BCL-XL Rabbit Polyclonal 18 BCL-XL Mouse Monoclonal 18 BIM/BOD Rabbit Polyclonal 18 Bnip3L Rabbit Polyclonal 18 BOB-1 Rabbit Monoclonal 18 BOB-1 Rabbit Polyclonal 18 Bone Morphogenetic Protein 4 (BMP-4) Rabbit Polyclonal 19
C C4d Rabbit Monoclonal 19 C4d Rabbit Polyclonal 19
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c-Abl Rabbit Polyclonal 19 Cadherin-E/E-Cadherin Rabbit Monoclonal 19 Cadherin-E/E-Cadherin Mouse Monoclonal 19 Cadherin-E/E-Cadherin Rabbit Polyclonal 20 Cadherin-N/N-Cadherin Rabbit Monoclonal 20 Cadherin-N/N-Cadherin Rabbit Polyclonal 20 Cadherin-pan Rabbit Polyclonal 20 Calbindin D28 Rabbit Polyclonal 20 Calcitonin Rabbit Monoclonal 20 Calcitonin Rabbit Polyclonal 21 Calcium Sensing Receptor (CaSR) Rabbit Polyclonal 21 Calpain Rabbit Monoclonal 21 Calpain Rabbit Polyclonal 21 Calpastatin Rabbit Monoclonal 21 Calpastatin Rabbit Polyclonal 21 Calretinin Rabbit Monoclonal 22 Calretinin Rabbit Polyclonal 22 CaM Kinase IV Rabbit Polyclonal 22 CaM Kinase Kinase alpha Rabbit Polyclonal 22 Carbonic Anhydrase 9 (CA-9) Rabbit Monoclonal 22 Carbonic Anhydrase 9 (CA-9) Rabbit Polyclonal 22 CAS Rabbit Polyclonal 23 Caspase-1 Rabbit Polyclonal 23 Caspase-8 Rabbit Polyclonal 23 Caspase-10 Rabbit Polyclonal 23 Catenin-beta Rabbit Polyclonal 23
International Orders Email: intlorders@springbio.com
117
Catenin-gamma Rabbit Polyclonal 23 Cathepsin D Rabbit Polyclonal 24 Caveolin-1 Rabbit Monoclonal 24 Caveolin-1 Rabbit Polyclonal 24 Caveolin-1 Rabbit Polyclonal 24 CBP/p300-Interacting Transactivator 1 (CITED-1) Rabbit Polyclonal 24 CCR7 Rabbit Polyclonal 24 CCR8 Rabbit Polyclonal 25 CD1 alpha Rabbit Polyclonal 25 CD2 Rabbit Polyclonal 25 CD3 Rabbit Monoclonal 25 CD3 Rabbit Polyclonal 25 CD3 zeta Rabbit Polyclonal 25 CD4 Rabbit Monoclonal 26 CD4 Rabbit Polyclonal 26 CD5 Rabbit Monoclonal 26 CD5 Rabbit Polyclonal 26 CD7 Rabbit Monoclonal 26 CD7 Rabbit Polyclonal 26 CD8 Rabbit Monoclonal 27 CD8 Rabbit Polyclonal 27 CD9 Rabbit Polyclonal 27 CD10 Rabbit Monoclonal 27 CD10 Rabbit Polyclonal 27 CD19 Rabbit Monoclonal 27 CD19 Rabbit Polyclonal 28 CD20 Rabbit Monoclonal 28 CD20 Rabbit Polyclonal 28 CD22 Rabbit Monoclonal 28 CD22 Rabbit Polyclonal 28 CD23 Rabbit Monoclonal 28 CD23 Rabbit Polyclonal 29 CD30 Rabbit Polyclonal 29 CD31 Rabbit Monoclonal 29 CD31 Rabbit Polyclonal 29 CD34 (Endothelial Cell Marker) Rabbit Polyclonal 29 CD34 (Endothelial Cell Marker) Mouse Monoclonal 29 CD38 Rabbit Polyclonal 30 CD40 Rabbit Polyclonal 30 CD43 Rabbit Monoclonal 30 CD43 Rabbit Polyclonal 30 CD44 Std Rabbit Monoclonal 30 CD44 Std Rabbit Polyclonal 30 CD44 Std Mouse Monoclonal 31 CD45/T200/LCA Mouse Monoclonal 31 CD45RA Mouse Monoclonal 31 CD56 Mouse Monoclonal 31 CD56 Mouse Monoclonal 31 CD63 Mouse Monoclonal 31 CD68 Rabbit Polyclonal 32 CD68 Rabbit Polyclonal 32 CD68 Rabbit Polyclonal 32 CD74 Mouse Monoclonal 32 CD79a Rabbit Monoclonal 32 CD79a Rabbit Polyclonal 32 CD95/FAS Rabbit Polyclonal 33 CD99 Rabbit Monoclonal 33 CD99/MIC2 Rabbit Polyclonal 33 CD105/Endoglin/TGF 1/3 Receptor Rabbit Polyclonal 33 CD117/c-kit Rabbit Monoclonal 33 CD117/c-kit Rabbit Polyclonal 33 CD138 Rabbit Polyclonal 34 CD146 Rabbit Polyclonal 34
118
CD150 Rabbit Polyclonal 34 CD163 Rabbit Monoclonal 34 CD163 Rabbit Polyclonal 34 CD168 Rabbit Polyclonal 34 CD274/B7-H1 Rabbit Polyclonal 35 CD278/ICOS Rabbit Monoclonal 35 CD278/ICOS Rabbit Polyclonal 35 CDC2 p34 Rabbit Polyclonal 35 CDH1 Rabbit Polyclonal 35 CDK2 Rabbit Monoclonal 35 CDK2 Rabbit Polyclonal 36 CDX2 Rabbit Monoclonal 36 CDX2 Rabbit Polyclonal 36 CEA/CD66e Rabbit Polyclonal 36 CEA/CD66e Mouse Monoclonal 36 c-erbB-2 (Paired 1248) Rabbit Polyclonal 36 c-erbB-2 (Phospho Y1248) Rabbit Polyclonal 37 c-erbB-2/HER-2 Rabbit Monoclonal 37 c-erbB-2/HER-2 Rabbit Polyclonal 37 c-erbB-3/HER-3 Rabbit Monoclonal 37 c-erbB-3/HER-3 Rabbit Polyclonal 37 c-erbB-3/HER-3 Rabbit Polyclonal 37 c-erbB-4/HER-4 Rabbit Polyclonal 38 c-Fos Rabbit Polyclonal 38 Cholecystokinin (CCK-8) Rabbit Polyclonal 38 Chromogranin A Rabbit Monoclonal 38 Chromogranin A Rabbit Polyclonal 38 Claudin-1 Rabbit Polyclonal 38 Claudin-3 Rabbit Polyclonal 39 Claudin-4 Rabbit Polyclonal 39 Claudin-5 Rabbit Polyclonal 39 Claudin-7 Rabbit Polyclonal 39 Claudin-10 Rabbit Polyclonal 39 Claudin-11 Rabbit Polyclonal 39 c-Met Rabbit Monoclonal 40 c-Met Rabbit Polyclonal 40 c-Met (Paired 1003) Rabbit Monoclonal 40 c-Met (Paired 1003) Rabbit Polyclonal 40 c-Met (Paired 1349) Rabbit Polyclonal 40 c-Met (Phospho Y1003) Rabbit Monoclonal 40 c-Met (Phospho Y1003) Rabbit Polyclonal 41 c-Met (Phospho Y1234/1235) Rabbit Polyclonal 41 c-Met (Phospho Y1349) Rabbit Polyclonal 41 Connexin-43 Rabbit Polyclonal 41 Corticotropin Releasing Factor (CRF) Rabbit Polyclonal 41 COX-1 Rabbit Polyclonal 41 COX-2 Rabbit Monoclonal 42 COX-2 Rabbit Polyclonal 42 CREB-Binding Protein (CBP) Rabbit Polyclonal 42 Cripto-1 Rabbit Polyclonal 42 c-TEN Rabbit Monoclonal 42 c-TEN Rabbit Polyclonal 42 Cullin-1 (CUL-1) Rabbit Polyclonal 43 Cullin-2 (CUL-2) Rabbit Polyclonal 43 CXCR4 Rabbit Polyclonal 43 Cyclin B1 Rabbit Polyclonal 43 Cyclin D1 Rabbit Monoclonal 43 Cyclin D1 Rabbit Polyclonal 43 Cyclin E Rabbit Polyclonal 44 CYR61 Rabbit Polyclonal 44 Cytochrome C Rabbit Polyclonal 44
D D4-GDI Rabbit Polyclonal 44 D5DR Rabbit Polyclonal 44 DAPK2 Rabbit Polyclonal 44 Desmin Rabbit Polyclonal 45 DFF-45 Rabbit Polyclonal 45 DHFR Rabbit Polyclonal 45 DJ-1 Rabbit Polyclonal 45 DOG-1 Rabbit Monoclonal 45 DOG-1 Rabbit Polyclonal 45 DOK-1 Rabbit Polyclonal 46 DOK-2 Rabbit Polyclonal 46 DRAK2 Rabbit Polyclonal 46 Dysferlin Rabbit Polyclonal 46 Dystrophin Rabbit Polyclonal 46 Dystrophin Mouse Monoclonal 46
E E2F-2 Rabbit Polyclonal 47 EGFL7 Rabbit Polyclonal 47 Ephrin A4 Rabbit Polyclonal 47 Epidermal Growth Factor Receptor (EGFR) Rabbit Monoclonal 47 Epidermal Growth Factor Receptor (EGFR) Rabbit Monoclonal 47 Epidermal Growth Factor Receptor (EGFR) Mouse Monoclonal 47 Epidermal Growth Factor Receptor (EGFR) Rabbit Polyclonal 48 ERAB Rabbit Polyclonal 48 ERCC1 Rabbit Monoclonal 48 ERCC1 Rabbit Polyclonal 48 ERCC1 Rabbit Polyclonal 48 ERK-1 Rabbit Polyclonal 48 ERK-2 Rabbit Polyclonal 49 ESA/Ep-CAM Mouse Monoclonal 49 Estrogen Receptor (ER) Rabbit Monoclonal 49 Estrogen Receptor (ER) Rabbit Polyclonal 49 EZH2 Rabbit Polyclonal 49
F F4/80 Rabbit Monoclonal 49 F4/80 Rabbit Polyclonal 50 FAS Ligand Rabbit Polyclonal 50 FAS-Associated Phosphatase (FAP-1) Rabbit Polyclonal 50 FcRH5 Rabbit Polyclonal 50 FGFR-1 Rabbit Polyclonal 50 FGFR-2 Rabbit Polyclonal 50 FGFR-3 Rabbit Polyclonal 51 FLI-1 Rabbit Polyclonal 51 FLK-1 (mouse) Rabbit Monoclonal 51 FLK-1/KDR/VEGFR-2 Rabbit Polyclonal 51 FLT-1/VEGFR1 Rabbit Polyclonal 51 FLT-4/VEGFR3 Rabbit Polyclonal 51 Fn14 Rabbit Polyclonal 52 FOXA1 Rabbit Monoclonal 52 FOXA1 Rabbit Polyclonal 52 FOXO1A Rabbit Polyclonal 52 FOXO3A Rabbit Polyclonal 52 FOXP1 Rabbit Polyclonal 52 FOXP3 Rabbit Monoclonal 53 FOXP3 Rabbit Polyclonal 53 FOXP4 Rabbit Polyclonal 53 FPGS Rabbit Polyclonal 53 FRA-2 Rabbit Polyclonal 53 Fragile Histidine Triad (FHIT) Rabbit Polyclonal 53
Product Index G GADD153 Rabbit Polyclonal 54 Gamma Glutamylcysteine Synthetase (GCS) Rabbit Polyclonal 54 GANP Rabbit Polyclonal 54 Gastrin-1 Rabbit Polyclonal 54 GDNF Rabbit Polyclonal 54 Glial Fibrillary Acidic Protein (GFAP) Rabbit Monoclonal 54 Glial Fibrillary Acidic Protein (GFAP) Rabbit Polyclonal 55 Glial Fibrillary Acidic Protein (GFAP) Mouse Monoclonal 55 Glucagon Rabbit Polyclonal 55 GluR1 Rabbit Polyclonal 55 GluR2/3 Rabbit Polyclonal 55 GluR6/7 Rabbit Polyclonal 55 GLUT-1 Rabbit Polyclonal 56 GLUT-1 Mouse Monoclonal 56 GLUT-3 Rabbit Polyclonal 56 Glutamic Acid Decarboxylase 65 (GAD65) Rabbit Polyclonal 56 Glutamic Acid Decarboxylase 67 (GAD67) Rabbit Polyclonal 56 Glypican-3 Rabbit Monoclonal 56 Glypican-3 Rabbit Polyclonal 57 GNB2 Rabbit Polyclonal 57 GP200 (Renal Cell Carcinoma Marker) Mouse Monoclonal 57 Granzyme B Rabbit Polyclonal 57 GRB2-Associated Binder 1 (GAB-1) Rabbit Polyclonal 57 GRP75 Rabbit Polyclonal 57 GRP78 Rabbit Polyclonal 58 GRP94 Rabbit Polyclonal 58 GRSF-1 Rabbit Polyclonal 58 GSK-3 Rabbit Polyclonal 58 Guanylyl Cyclase beta Rabbit Polyclonal 58
H H. Pylori Rabbit Polyclonal 58 H. Pylori Mouse Monoclonal 59 HDAC1 Rabbit Polyclonal 59 HDAC2 Rabbit Polyclonal 59 Heat Shock Protein 60 (HSP60) Rabbit Polyclonal 59 Heat Shock Protein 70 (HSP70) Rabbit Polyclonal 59 hENT1 Rabbit Monoclonal 59 HMGA2 Rabbit Polyclonal 60 Human Growth Hormone (HGH) Rabbit Polyclonal 60
I ID2 Rabbit Polyclonal 60 ID3 Rabbit Polyclonal 60 IKAROS Rabbit Monoclonal 60 IKAROS Rabbit Polyclonal 60 Inhibin-alpha Rabbit Polyclonal 61 Integrin beta 5 Rabbit Polyclonal 61 Involucrin Rabbit Polyclonal 61 IPO-38 (Proliferation Marker) Mouse Monoclonal 61 IRS-1 Rabbit Polyclonal 61
J JAB1 Rabbit Polyclonal 61 J-chain Rabbit Monoclonal 62 J-chain Rabbit Polyclonal 62 Jena-Muenchen4 (JM4) Rabbit Polyclonal 62
K Kappa Light Chain (B Cell Marker) Mouse Monoclonal 62 Keratin 5 Rabbit Monoclonal 62
MMP-3 (Stromelysin-1) Rabbit Polyclonal 72 MMP-9 (92kDa Collagenase IV) Rabbit Polyclonal 72 MMP-10 (Stromelysin-2) Rabbit Polyclonal 73 MMP-14/MT1-MMP Rabbit Polyclonal 73 MMP-15/MT2-MMP Rabbit Polyclonal 73 MMP-19 Rabbit Polyclonal 73 MMP-23 Rabbit Polyclonal 73 MSH2 Rabbit Monoclonal 73 MSH2 Rabbit Polyclonal 74 MSH3 Rabbit Polyclonal 74 MSH6 Rabbit Monoclonal 74 MSH6 Mouse Monoclonal 74 MSH6 Rabbit Polyclonal 74 mTOR Rabbit Polyclonal 74 mTOR Rabbit Polyclonal 75 MUC-1 Underglycosylated Mouse Monoclonal 75 MUC-1/EMA/Epithelial Membrane Antigen Rabbit Polyclonal 75 MUC-1/EMA/Epithelial Membrane Antigen Mouse Monoclonal 75 Mucin 5AC Mouse Monoclonal 75 Mucin 5AC Mouse Monoclonal 75 Mucin-2/MUC-2 Mouse Monoclonal 76 MUM1/IRF4 Rabbit Monoclonal 76 MUM1/IRF4 Rabbit Polyclonal 76 Myeloperoxidase (MPO) Rabbit Monoclonal 76 Myeloperoxidase (MPO) Rabbit Polyclonal 76 Myoglobin Rabbit Polyclonal 76
Keratin 5 Rabbit Polyclonal 62 Keratin 6 Rabbit Monoclonal 63 Keratin 6 Rabbit Polyclonal 63 Keratin 7 Rabbit Monoclonal 63 Keratin 7 Rabbit Polyclonal 63 Keratin 8 Rabbit Monoclonal 63 Keratin 8 Rabbit Polyclonal 63 Keratin 8 Rabbit Polyclonal 64 Keratin 10 Rabbit Monoclonal 64 Keratin 10 Rabbit Polyclonal 64 Keratin 14 Rabbit Monoclonal 64 Keratin 14 Rabbit Polyclonal 64 Keratin 17 Rabbit Monoclonal 64 Keratin 17 Rabbit Polyclonal 65 Keratin 18 Rabbit Monoclonal 65 Keratin 18 Rabbit Polyclonal 65 Keratin 18 Mouse Monoclonal 65 Keratin 18 Mouse Monoclonal 65 Keratin 19 Rabbit Polyclonal 65 Keratin 20 Rabbit Monoclonal 66 Keratin 20 Rabbit Polyclonal 66 Ki-67 Rabbit Monoclonal 66 Ki-67 Rabbit Polyclonal 66 KOC/L523S Rabbit Polyclonal 66 k-Ras Rabbit Polyclonal 66 Ku80 Rabbit Polyclonal 67 Ku80 Rabbit Polyclonal 67
N
L Lambda Light Chain Rabbit Polyclonal 67 Lamin B Rabbit Polyclonal 67 Lewis A Mouse Monoclonal 67 LIMD1 Rabbit Polyclonal 67 Lipocalin-2 Rabbit Polyclonal 68 LMO2 Rabbit Monoclonal 68 LMO2 Rabbit Polyclonal 68 LMO2 Mouse Monoclonal 68 Luteinizing Hormone (LH) Rabbit Polyclonal 68
M MAGE-1 Rabbit Polyclonal 68 MALT-1 Rabbit Polyclonal 69 Mammaglobin Rabbit Polyclonal 69 MART-1/Melan-A Rabbit Polyclonal 69 MCL-1 Rabbit Polyclonal 69 MCM2 Rabbit Monoclonal 69 MCM2 Rabbit Polyclonal 69 MCM2 Rabbit Polyclonal 70 MCM5 Rabbit Polyclonal 70 MDGI Rabbit Polyclonal 70 MDGI Rabbit Polyclonal 70 MDM2 Rabbit Polyclonal 70 MEF-2 Rabbit Polyclonal 70 Melanoma (gp100) Rabbit Polyclonal 71 Mesothelin Rabbit Monoclonal 71 Mesothelin Rabbit Polyclonal 71 mGluR1 Rabbit Polyclonal 71 mGluR5 Rabbit Polyclonal 71 Microphthalmia (MiTF) Rabbit Polyclonal 71 MIP-1 alpha Rabbit Polyclonal 72 MLH1 Rabbit Polyclonal 72 MMP-1 Rabbit Polyclonal 72 MMP-2 (72kDa Collagenase IV) Rabbit Polyclonal 72
US Orders Online: www.springbio.com Email: orders@springbio.com Tel: (925) 474-8440 Fax: (925) 474-8469
NCK2 Rabbit Polyclonal 77 Nephrin Rabbit Polyclonal 77 Nestin Rabbit Monoclonal 77 Nestin Rabbit Polyclonal 77 Nestin Rabbit Polyclonal 77 Neuron Specific Enolase (NSE) Rabbit Polyclonal 77 NFkB p50 Rabbit Polyclonal 78 NFkB p65 Rabbit Polyclonal 78 Nitric Oxide Synthase-Endothelial (eNOS) Rabbit Polyclonal 78 Nitric Oxide Synthase-Inducible (iNOS) Rabbit Monoclonal 78 Nitric Oxide Synthase-Inducible (iNOS) Rabbit Polyclonal 78 Nitric Oxide Synthase-Universal (uNOS) Rabbit Polyclonal 78 NKX3.1 Rabbit Polyclonal 79 Notch-1 Rabbit Polyclonal 79 NRF2 Rabbit Polyclonal 79
O Occludin Rabbit Polyclonal 79 OCT-1 Rabbit Polyclonal 79 OCT-2 Rabbit Polyclonal 79 OCT-3/OCT-4 Rabbit Polyclonal 80 OCT-3/OCT-4 Rabbit Polyclonal 80 Osteopontin Rabbit Polyclonal 80
P p120 (catenin delta 1) Rabbit Monoclonal 80 p120 (catenin delta 1) Rabbit Polyclonal 80 p14ARF Rabbit Polyclonal 80 p27Kip1 Rabbit Polyclonal 81 p300/CBP Rabbit Polyclonal 81 p53 Rabbit Monoclonal 81 p53 Rabbit Polyclonal 81 p53 Mouse Monoclonal 81 p57 Rabbit Monoclonal 81 p57 Rabbit Polyclonal 82
International Orders Email: intlorders@springbio.com
119
p70S6k Rabbit Polyclonal 82 p70S6k (Paired 421/424) Rabbit Polyclonal 82 p70S6k (Phospho T421/S424) Rabbit Polyclonal 82 PAK alpha Rabbit Polyclonal 82 Parathyroid Hormone Rabbit Polyclonal 82 Parathyroid Hormone Receptor 1 Rabbit Polyclonal 83 Parkin Rabbit Polyclonal 83 PAX-5 Rabbit Monoclonal 83 PAX-5 Rabbit Polyclonal 83 Paxillin Rabbit Polyclonal 83 PCNA Rabbit Polyclonal 83 PD-1/CD279 Rabbit Polyclonal 84 PD-1/CD279 Rabbit Polyclonal 84 PDCD6 Rabbit Polyclonal 84 PDGFR alpha Rabbit Polyclonal 84 PDGFR beta Rabbit Polyclonal 84 PDK-1 Rabbit Polyclonal 84 PDS-1/Securin Rabbit Polyclonal 85 Peripheral Myelin Protein (PMP-22) Rabbit Polyclonal 85 Phospho-Ser/Thr/Tyr Mouse Monoclonal 85 Phosphotyrosine Mouse Monoclonal 85 PI3K p110beta Rabbit Polyclonal 85 PI3K p85 Rabbit Monoclonal 85 PI3K p85 Rabbit Polyclonal 86 PIM-1 Rabbit Polyclonal 86 PIM-2 Rabbit Polyclonal 86 Placental Lactogen (hPL) Rabbit Polyclonal 86 PLAP Rabbit Monoclonal 86 PLAP Rabbit Polyclonal 86 PLC beta 1 Rabbit Polyclonal 87 PLC gamma 2 Rabbit Polyclonal 87 Pleiotrophin Rabbit Polyclonal 87 PML Rabbit Polyclonal 87 PMS2 Rabbit Polyclonal 87 Podocin Rabbit Polyclonal 87 Poly ADP-Ribose Polymerase (PARP) Rabbit Polyclonal 88 Potassium Channel Kv3.2 Rabbit Polyclonal 88 Presenilin Rabbit Polyclonal 88 Progesterone Receptor (PR) Rabbit Monoclonal 88 Progesterone Receptor (PR) Rabbit Monoclonal 88 Progesterone Receptor (PR) Rabbit Polyclonal 88 Prohibitin Rabbit Polyclonal 89 Prolactin Rabbit Polyclonal 89 Prostate Apoptosis Response 4 (PAR-4) Rabbit Polyclonal 89 Prostate Specific Antigen (PSA) Rabbit Polyclonal 89 Prostate Stem Cell Antigen (PSCA) Rabbit Polyclonal 89 Protein Gene Protein 9.5 (PGP9.5) Rabbit Polyclonal 89 PSMA Rabbit Monoclonal 90 PSMA Rabbit Polyclonal 90
R RACK-1 Rabbit Polyclonal 90 RAD51 Rabbit Polyclonal 90 RAN Rabbit Polyclonal 90 RCAS1 Rabbit Polyclonal 90 RCC1 Rabbit Polyclonal 91 Retinoblastoma (Rb) Rabbit Polyclonal 91 Retinoic Acid Receptor beta Rabbit Polyclonal 91 Retinoic X Receptor gamma Rabbit Polyclonal 91 RHO Rabbit Polyclonal 91 ROC1 Rabbit Polyclonal 91 RRM1 Rabbit Polyclonal 92
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S S100 Rabbit Polyclonal 92 S100A4 Rabbit Polyclonal 92 S6 Ribosomal Rabbit Polyclonal 92 S6 Ribosomal (Paired 235/236) Rabbit Polyclonal 92 S6 Ribosomal (Paired 240/244) Rabbit Polyclonal 92 S6 Ribosomal (Phospho S235/236) Rabbit Monoclonal 93 S6 Ribosomal (Phospho S235/236) Rabbit Polyclonal 93 S6 Ribosomal (Phospho S240/244) Rabbit Monoclonal 93 S6 Ribosomal (Phospho S240/244) Rabbit Polyclonal 93 SHIP-1 Rabbit Polyclonal 93 SH-PTP2 Rabbit Polyclonal 93 SKP1 p19 Rabbit Polyclonal 94 SKP2 p45 Rabbit Polyclonal 94 SLIT2 Rabbit Monoclonal 94 SLIT2 Rabbit Polyclonal 94 SMA Rabbit Polyclonal 94 SMAD3 Rabbit Polyclonal 94 SMRTe Rabbit Polyclonal 95 SOCS-2 Rabbit Polyclonal 95 SOCS-3 Rabbit Polyclonal 95 SOCS-6 Rabbit Polyclonal 95 Sodium Channel-pan Rabbit Polyclonal 95 Sonic Hedgehog Rabbit Polyclonal 95 SOX-2 Rabbit Monoclonal 96 SOX-2 Rabbit Polyclonal 96 SOX-4 Rabbit Polyclonal 96 SOX-9 Rabbit Polyclonal 96 SOX-9 Rabbit Polyclonal 96 SOX-11 Rabbit Polyclonal 96 SOX-14 Rabbit Polyclonal 97 SP1 Rabbit Polyclonal 97 ST13 Rabbit Polyclonal 97 Stanniocalcin-2 Rabbit Polyclonal 97 STAT3 Rabbit Polyclonal 97 STAT5 alpha Rabbit Polyclonal 97 STAT6 Rabbit Polyclonal 98 Stathmin Rabbit Monoclonal 98 Stathmin Rabbit Polyclonal 98 Survivin Rabbit Monoclonal 98 Survivin Rabbit Polyclonal 98 SYK Rabbit Polyclonal 98 Synaptophysin Rabbit Monoclonal 99 Synaptophysin Rabbit Polyclonal 99 Syntaxin 1A Rabbit Monoclonal 99 Syntaxin 1A Rabbit Polyclonal 99 Synuclein-alpha Rabbit Polyclonal 99 Synuclein-beta Rabbit Polyclonal 99 Synuclein-pan Rabbit Polyclonal 100
T Tau (Neuronal Marker) Rabbit Monoclonal 100 Tau (Neuronal Marker) Rabbit Polyclonal 100 TdT Rabbit Polyclonal 100 Thioredoxin Reductase 2 (TrxR2) Rabbit Polyclonal 100 Thrombin R/ATAP2 Rabbit Polyclonal 100 Thymidylate Synthase (TS) Rabbit Monoclonal 101 Thymidylate Synthase (TS) Rabbit Polyclonal 101 Thymidylate Synthase (TS) Rabbit Polyclonal 101 Thyroglobulin Mouse Monoclonal 101 Thyroid Hormone Receptor alpha1/alpha2 Rabbit Polyclonal 101 Thyroid Hormone Receptor beta Rabbit Polyclonal 101
Thyroid Stimulating Hormone (TSH) Rabbit Polyclonal 102 TIE-1 Rabbit Polyclonal 102 TIMP-1 Rabbit Polyclonal 102 TIMP-2 Rabbit Polyclonal 102 TIMP-3 Rabbit Polyclonal 102 TNF-R2 Rabbit Polyclonal 102 Topo II beta Rabbit Polyclonal 103 Topoisomerase I Rabbit Polyclonal 103 Toxoplasma Gondii Rabbit Polyclonal 103 TRADD Rabbit Polyclonal 103 Transforming Growth Factor beta R3 Rabbit Polyclonal 103 Transforming Growth Factor beta1 (TGFb1) Rabbit Polyclonal 103 Transforming Growth Factor beta2 (TGFb2) Rabbit Polyclonal 104 Transforming Growth Factor beta3 (TGFb3) Rabbit Polyclonal 104 Transforming Growth Factor R1 Rabbit Polyclonal 104 Transglutaminase II Rabbit Polyclonal 104 TTF-1 Rabbit Polyclonal 104 TTF-1 Mouse Monoclonal 104 Tubulin-alpha Rabbit Polyclonal 105 Tubulin-beta Rabbit Polyclonal 105 Tubulin-gamma Rabbit Polyclonal 105
U Ubiquitin Rabbit Polyclonal 105 Urocortin Rabbit Polyclonal 105 Uroplakin III Rabbit Monoclonal 105 Uroplakin III Rabbit Polyclonal 106 USF-2 Rabbit Polyclonal 106
V Vascular Endothelial Growth Factor (VEGF) Rabbit Monoclonal 106 Vascular Endothelial Growth Factor (VEGF) Rabbit Polyclonal 106 Villin Rabbit Polyclonal 106 Vimentin Rabbit Monoclonal 106 Vinculin Rabbit Monoclonal 107 Vinculin Rabbit Polyclonal 107
W Wilm’s Tumor (WT) Rabbit Polyclonal 107 WNT-1 Rabbit Polyclonal 107
X XMRV Rabbit Polyclonal 107 XRCC2 Rabbit Polyclonal 107
Z ZAP-70 Rabbit Polyclonal 108 ZO-3 Rabbit Polyclonal 108
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