Epilepsia em doenรงas neurodegenerativas e envelhecimento Epilepsy in Neurodegenerative Diseases and Aging 16 Fev. a 25 Fev., 2014, Sรฃo Paulo, Brasil
8TH. Latin-American Summer School on Epilepsy - LASSE VIII
8ª. ESCOLA LATINO-AMERICANA DE VERÃO EM EPILEPSIA 8ª. ESCUELA LATINO-AMERICANA DE VERANO EN EPILEPSIA 8th. LATIN-AMERICAN SUMMER SCHOOL ON EPILEPSY (LASSE) SÃO PAULO, BRASIL 16 A 25 DE FEVEREIRO DE 2014 Centro de Convenções Santa Mônica COORDENAÇÃO GERAL Prof. Dr. Esper A. Cavalheiro
COMISSÃO LATINO AMERICANA DA INTERNATIONAL LEAGUE AGAINST EPILEPSY (ILAE) Prof. Dr. Marco Túlio Medina
ACADEMIA LATINO AMERICANA DE EPILEPSIA DA INTERNATIONAL LEAGUE AGAINST EPILEPSY (ILAE) Profa. Dra. Elza Márcia Yacubian – Universidade Federal de São Paulo
PRESIDENTE DA LIGA BRASILEIRA DE EPILEPSIA (LBE) Dr. Luciano de Paola- Universidade Federal do Paraná, Curitiba
PRESIDENTE DA ILAE Prof. Dr. Emilio Perucca
COMISSÃO ORGANIZADORA Elza Márcia Yacubian - UNIFESP Esper A. Cavalheiro - UNIFESP Fernando Cendes - UNICAMP Fulvio Alexandre Scorza - UNIFESP Jaime Carrizosa – Universidade de Antioquia
EPILEPSIA EM DOENÇAS NEURODEGENERATIVAS E ENVELHECIMENTO
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8ª. Escola Latino-Americana de Verão em Epilepsia (LASSE) é uma atividade da lnternational League Against Epilepsy (ILAE) e da Academia Latino Americana de Epilepsia (ALA-
DE) com o apoio da Liga Brasileira de Epilepsia (LBE). Com início em 2002, as “Escolas de verão em epilepsia”, organizadas pela International League Against Epilepsy (ILAE) têm se tornado uma referência como experiência didática. Como professores e alunos permanecem em contato bastante próximo por quase duas semanas consecutivas, esse tipo de Escola tem facilitado a integração entre pesquisadores e alunos permitindo uma melhor compreensão das novas descobertas para o beneficio das pessoas com epilepsia. A oitava edição “Escola Latino-Americana de Verão em Epilepsia (LASSE)” realizada em Guarulhos entre 16 a 25 de fevereiro de 2014 aborda o tema Epilepsia em Doenças Neurodegenerativas e Envelhecimento. Agradecendo aos professores e tutores que de forma tão generosa abandonam seus afazeres e nos oferecem seu tempo damos boas-vindas aos alunos da LASSE-VIII, razão maior do nosso trabalho. A Comissão Organizadora
ÍNDICE 8TH. LATIN-AMERICAN SUMMER SCHOOL ON EPILEPSY - LASSE VIII “Epilepsy in neurodegenerative diseases and aging” 16 a 25 February 2014 – São Paulo, Brazil PROGRAM
16 Feb. 11:00-12:00 14:00-15:00 15:00-16:00 16:30-17:30 17:30-18:30
Concept of focal and generalized ictogenesis – Peter Wolf (Denmark).........................................................................6 Neonatal seizures – Loreto Rios (Chile).....................................................................................................................20 Seizures in childhood – Vera Terra (Brazil).................................................................................................................32 Seizures in adults – Elza Marcia Yacubian (Brazil).....................................................................................................47 Seizures in the elderly – Tonicarlo Velasco (Brazil)....................................................................................................71
17 Feb. 09:00-10:00 10:00-11:00 11:30-12:30 14:00-15:00 16:30-17:30 17:30-18:30
Neuronal death: different paths to the same fate – João Malva (Portugal)...................................................................72 Oxidative stress and neuronal cell death – Catarina Oliveira (Portugal).....................................................................73 Excitotoxicity: glutamate out of the cage – João Malva (Portugal)..............................................................................84 Brain barriers I – Joana Palha (Portugal).....................................................................................................................85 Antiepileptic drug treatment in pregnancy with focus in teratogenicity – Torbjorn Tomsom (Sweden)........................86 Tuberous sclerosis – Sergiusz Jozwiak (Poland)..........................................................................................................96
18 Feb. 09:00-10:00 10:00-11:00 11:30-12:30 14:00-15:00 15:00-16:00 16:30-17:30 17:30-18:30
Astrocyte-neuron homeostasis – Rodrigo Cunha (Portugal)........................................................................................97 Neurogenesis in epilepsy – Helen Scharfman (USA)..................................................................................................98 West Syndrome – Sergiusz Jozwiak (Poland).............................................................................................................99 Brain barriers II – Joana Palha (Portugal)..................................................................................................................100 Caffeine and adenosine receptors in the control of epileptic-like features – Rodrigo Cunha (Portugal).....................117 Antiepileptic drugs and SUDEP – Torbjorn Tomson (Sweden)..................................................................................118 The neurogenic niche dynamics – João Malva (Portugal).........................................................................................128
19 Feb. 08:30-09:30 09:30-10:30 11:00-12:00 14:00-15:00 15:00-16:00 16:30-17:30
Main inborn errors of metabolism – Fernando Kok (Brazil)......................................................................................129 Investigating genetic syndromes: main aspects – Iscia Lopes Cendes (Brazil)...........................................................130 Rett syndrome – Jaime Carrizosa Moog (Colombia).................................................................................................140 Angelman syndrome – Kette Valente (Brazil)...........................................................................................................145 Seizures in Alzheimer Disease – Helen Scharfman (USA)........................................................................................164 Neuroimaging in brain malformations related to epilepsy – Fernando Cendes (Brazil).............................................165
20 Feb. 08:30-09:30 09:30-10:30 11:00-12:00 14:00-15:00 15:00-16:00 16:30-17:30
Epilepsy in autoimmune encephalitis – Maria Chiara Stefanini (Italy)......................................................................193 Encephalopathy related to Status Epilepticus during Sleep (ESES) – Carlo Alberto Tassinari (Italy) ...........................194 Dravet Syndrome – Elza Marcia Yacubian (Brazil) ...................................................................................................195 PME – Jesus Machado-Salas (USA)..........................................................................................................................207 Focal epilepsies: progressive disorders? – Fernando Cendes (Brazil)........................................................................221 First Seizure Management – Diagnostic and treatment algorithm in late onset epilepsies – Bernard Pohlmann-Eden (Canada).................................................................................................................................................................238 17:30-18:30 Characteristics of epilepsy in adult and aged women – Patricia Braga (Uruguay.....................................................266)
21 Feb. 08:30-09:30 09:30-10:30 11:00-12:00 14:00-15:00 15:00-16:00 16:30-17:30 20:00-21:30
Status epilepticus-induced epilepsy: experimental observations – João Pereira Leite (Brazil)....................................280 Approach to medically resistant epilepsy – Cigden Ozkara (Turkey)........................................................................281 Epilepsy surgery and presurgical evaluation – Cigden Ozkara (Turkey)....................................................................282 FIREs – Roberto Caraballo (Argentina).....................................................................................................................283 Which really matters: the etiology or the spikes? – Alicia Bogacz (Uruguay)............................................................292 Does some MTLE represent a progressive degenerative disorder? – Roberto Spreafico (Italy)...................................298 ALADE Conference: Neurodegenerative diseases: the look of a pediatric neurologist – Jaderson Costa da Costa (Brazil)...........................................................................................................................................................308
22 Feb. 09:00-10:00 The Struldbruggs and neurodegeneration – Marina Bentivoglio (Italy.....................................................................309) 10:00-11:00 What do we know about the neurobiology of cognitive decline in “normal” aging and in neurodegenerative diseases? – Giuseppe Bertini (Italy).........................................................................................................................................310 11:30-12:30 Brain aging and neuroplasticity – Marina Bentivoglio (Italy)....................................................................................311 14:00-15:00 Cognitive and brain changes in asymptomatic persons at increased risk for Alzheimer’s disease – Bruce Hermann (USA)......................................................................................................................................................................312 15:00-16:00 Seizures and dementia in Down’s syndrome – Laura Guilhoto (Brazil)....................................................................327 16:30-17:30 Classification of status epilepticus – Guilca Contreras (Venezuela)..........................................................................349 17:30-18:30 Electroencephalographic status epilepticus – Luis Otávio Caboclo (Brazil)..............................................................360 23 Feb. 08:30-09:30 09:30-10:30 11:00-12:00 14:00-15:00 15:00-16:00
Translational research: Finding a better drug for epilepsy – Astrid Nehlig (France)...................................................397 Neuropsychological and brain changes in aging persons with chronic epilepsy – Bruce Hermann (USA)................408 Psychiatric effects of AEDs – Andres Kanner (USA)..................................................................................................424 Acute treatment of epilepsy – Peter Wolf (Denmark)................................................................................................425 Transcranial magnetic stimulation in epilepsy refractory to drug treatment – Lilia Morales Chacon (Cuba)..............432
24 Feb. – Surgical approach of the epilepsies 08:30-09:30 The need for presurgical evaluation – Silvia Kochen (Argentina)..............................................................................444 09:30-10:30 Surgery in tuberous sclerosis complex – Hélio Rubens Machado (Brazil)................................................................456 11:00-12:00 Surgery in focal cortical dysplasias – Manuel Campos (Chile).................................................................................463 12:00-13:00 Surgery in PWE older than 50 years – Mario Alonso (Mexico).................................................................................464 25 Feb. – Group presentations 09:00-18:00 Presentations + coffee-breaks + lunch 20:00 Farewell dinner
Peter Wolf (Denmark)
CONCEPT OF FOCAL AND GENERALIZED ICTOGENESIS
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Loreto Rios (Chile)
NEONATAL SEIZURES
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Vera Terra (Brazil)
SEIZURES IN CHILDHOOD
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Elza Marcia Yacubian (Brazil)
SEIZURES IN ADULTS
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Tonicarlo Velasco (Brazil)
SEIZURES IN THE ELDERLY
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João Malva (Portugal)
NEURONAL DEATH: DIFFERENT PATHS TO THE SAME FATE
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Catarina Oliveira (Portugal)
OXIDATIVE STRESS AND NEURONAL CELL DEATH
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João Malva (Portugal)
EXCITOTOXICITY: GLUTAMATE OUT OF THE CAGE
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Joana Palha (Portugal)
BRAIN BARRIERS I
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Torbjorn Tomson (Sweden)
ANTIEPILEPTIC DRUG TREATMENT IN PREGNANCY WITH FOCUS IN TERATOGENICITY
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Sergiusz Jozwiak (Poland)
TUBEROUS SCLEROSIS
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Rodrigo Cunha (Portugal)
ASTROCYTE-NEURON HOMEOSTASIS
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Helen Scharfman (USA)
NEUROGENESIS IN EPILEPSY
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Sergiusz Jozwiak (Poland)
WEST SYNDROME
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Joana Palha (Portugal)
BLOOD-BRAIN BARRIERS II
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Rodrigo Cunha (Portugal)
CAFFEINE AND ADENOSINE RECEPTORS IN THE CONTROL OF EPILEPTIC-LIKE FEATURES
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Torbjorn Tomson (Sweden)
ANTIEPILEPTIC DRUGS AND SUDEP
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João Malva (Portugal)
THE NEUROGENIC NICHE DYNAMICS
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Fernando Kok (Brazil)
MAIN INBORN ERRORS OF METABOLISM
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Iscia Lopes Cendes (Brazil)
INVESTIGATING GENETIC SYNDROMES: MAIN ASPECTS
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Jaime Carrizosa Moog (Colombia)
RETT SYNDROME
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Kette Valente (Brazil)
ANGELMAN SYNDROME
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Helen Scharfman (USA)
SEIZURES IN ALZHEIMER’S DISEASE
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Fernando Cendes (Brazil)
NEUROIMAGING IN BRAIN MALFORMATIONS RELATED TO EPILEPSY
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Maria Chiara Stefanini (Italy)
EPILEPSY IN AUTOIMMUNE ENCEPHALITIS
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Carlo Alberto Tassinari (Italy)
ENCEPHALOPATHY RELATED TO STATUS EPILEPTICUS DURING SLEEP (ESES)
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Elza Mรกrcia Yacubian (Brazil)
DRAVET SYNDROME
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Jesus Machado Salas (USA)
PME
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Fernando Cendes (Brazil)
FOCAL EPILEPSIES: PROGRESSIVE DISORDERS?
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Bernd Pohlmann-Eden (Canada)
FIRST SEIZURE MANAGEMENT - DIAGNOSTIC AND TREATMENT ALGORITHM IN LATE ONSET EPILEPSIES
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Patricia Braga (Uruguay)
EPILEPSY IN ADULT AND AGED WOMEN
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João Pereira Leite (Brazil)
STATUS EPILEPTICUS-INDUCED EPILEPSY: EXPERIMENTAL OBSERVATIONS
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Cigden Ozkara (Turkey)
APPROACH TO MEDICALLY RESISTANT EPILEPSY
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Cigden Ozkara (Turkey)
EPILEPSY SURGERY AND PRESURGICAL EVALUATION
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Roberto Caraballo (Argentina)
FIRES
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Alicia Bogacz (Uruguay)
WHICH REALLY MATTERS: THE ETIOLOGY OR THE SPIKES?
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Roberto Spreafico (Italy)
DOES SOME MTLE REPRESENT A PROGRESSIVE DEGENERATIVE DISORDER?
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Jaderson Costa da Costa (Brazil)
ALADE CONFERENCE: NEURODEGENERATIVE DISEASES: THE LOOK OF A PEDIATRIC NEUROLOGIST
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Marina Bentivoglio (Italy)
THE STRULDBRUGGS AND NEURODEGENERATION
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Giuseppe Bertini (Italy)
WHAT DO WE KNOW ABOUT THE NEUROBIOLOGY OF COGNITIVE DECLINE IN NORMAL “AGING” AND IN NEURODEGENERATIVE DISEASES?
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Marina Bentivoglio (Italy)
BRAIN AGING AND NEUROPLASTICITY
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Bruce Hermann (USA)
COGNITIVE AND BRAIN CHANGES IN ASYMPTOMATIC PERSONS AT INCREASED RISK FOR ALZHEIMER’S DISEASE
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Laura Guilhoto (Brazil)
SEIZURES AND DEMENTIA IN DOWN’S SYNDROME
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Guilca Contreras (Venezuela)
CLASSIFICATION OF STATUS EPILEPTICUS
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Luis Otรกvio Caboclo (Brazil)
ELECTROENCEPHALOGRAPHIC STATUS EPILEPTICUS
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Astrid Nehlig (France)
TRANSLATIONAL RESEARCH: FINDING A BETTER DRUG FOR EPILEPSY
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Bruce Hermann (USA)
NEUROPSYCHOLOGICAL AND BRAIN CHANGES IN AGING PERSONS WITH CHRONIC EPILEPSY
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Andres Kanner (USA)
PSYCHIATRIC EFFECTS OF AEDS
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Peter Wolf (Denmark)
ACUTE TREATMENT OF EPILEPSY
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Lilia Morales Chacon (Cuba)
TRANSCRANIAL MAGNETIC STIMULATION IN EPILEPSY REFRACTORY TO DRUG TREATMENT
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Silvia Kochen (Argentina)
THE NEED FOR PRESURGICAL EVALUATION
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Hélio Rubens Machado (Brazil)
SURGERY IN TUBEROUS SCLEROSIS COMPLEX
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Manuel Campos (Chile)
SURGERY IN FOCAL CORTICAL DYSPLASIAS
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Mario Alonso (Mexico)
SURGERY IN PWE OLDER THAN 50 YEARS
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Organização:
Instituto Nacional de Neurociência Translacional
Apoio:
HUG-CELL CEPID