EPILEPSIA EM DOENÇAS NEURODEGENERATIVAS E ENVELHECIMENTO

Epilepsia em doenรงas neurodegenerativas e envelhecimento Epilepsy in Neurodegenerative Diseases and Aging 16 Fev. a 25 Fev., 2014, Sรฃo Paulo, Brasil

8TH. Latin-American Summer School on Epilepsy - LASSE VIII

8ª. ESCOLA LATINO-AMERICANA DE VERÃO EM EPILEPSIA 8ª. ESCUELA LATINO-AMERICANA DE VERANO EN EPILEPSIA 8th. LATIN-AMERICAN SUMMER SCHOOL ON EPILEPSY (LASSE) SÃO PAULO, BRASIL 16 A 25 DE FEVEREIRO DE 2014 Centro de Convenções Santa Mônica COORDENAÇÃO GERAL Prof. Dr. Esper A. Cavalheiro

COMISSÃO LATINO AMERICANA DA INTERNATIONAL LEAGUE AGAINST EPILEPSY (ILAE) Prof. Dr. Marco Túlio Medina

ACADEMIA LATINO AMERICANA DE EPILEPSIA DA INTERNATIONAL LEAGUE AGAINST EPILEPSY (ILAE) Profa. Dra. Elza Márcia Yacubian – Universidade Federal de São Paulo

PRESIDENTE DA LIGA BRASILEIRA DE EPILEPSIA (LBE) Dr. Luciano de Paola- Universidade Federal do Paraná, Curitiba

PRESIDENTE DA ILAE Prof. Dr. Emilio Perucca

COMISSÃO ORGANIZADORA Elza Márcia Yacubian - UNIFESP Esper A. Cavalheiro - UNIFESP Fernando Cendes - UNICAMP Fulvio Alexandre Scorza - UNIFESP Jaime Carrizosa – Universidade de Antioquia

EPILEPSIA EM DOENÇAS NEURODEGENERATIVAS E ENVELHECIMENTO

A

8ª. Escola Latino-Americana de Verão em Epilepsia (LASSE) é uma atividade da lnternational League Against Epilepsy (ILAE) e da Academia Latino Americana de Epilepsia (ALA-

DE) com o apoio da Liga Brasileira de Epilepsia (LBE).

Com início em 2002, as “Escolas de verão em epilepsia”, organizadas pela International League Against Epilepsy (ILAE) têm se tornado uma referência como experiência didática. Como professores e alunos permanecem em contato bastante próximo por quase duas semanas consecutivas, esse tipo de Escola tem facilitado a integração entre pesquisadores e alunos permitindo uma melhor compreensão das novas descobertas para o beneficio das pessoas com epilepsia. A oitava edição “Escola Latino-Americana de Verão em Epilepsia (LASSE)” realizada em Guarulhos entre 16 a 25 de fevereiro de 2014 aborda o tema Epilepsia em Doenças Neurodegenerativas e Envelhecimento.

Agradecendo aos professores e tutores que de forma tão generosa abandonam seus afazeres e nos oferecem seu tempo damos boas-vindas aos alunos da LASSE-VIII, razão maior do nosso trabalho.

A Comissão Organizadora

ÍNDICE 8TH. LATIN-AMERICAN SUMMER SCHOOL ON EPILEPSY - LASSE VIII “Epilepsy in neurodegenerative diseases and aging” 16 a 25 February 2014 – São Paulo, Brazil PROGRAM

16 Feb. 11:00-12:00 14:00-15:00 15:00-16:00 16:30-17:30 17:30-18:30

Concept of focal and generalized ictogenesis – Peter Wolf (Denmark).........................................................................6 Neonatal seizures – Loreto Rios (Chile).....................................................................................................................20 Seizures in childhood – Vera Terra (Brazil).................................................................................................................32 Seizures in adults – Elza Marcia Yacubian (Brazil).....................................................................................................47 Seizures in the elderly – Tonicarlo Velasco (Brazil)....................................................................................................71

17 Feb. 09:00-10:00 10:00-11:00 11:30-12:30 14:00-15:00 16:30-17:30 17:30-18:30

Neuronal death: different paths to the same fate – João Malva (Portugal)...................................................................72 Oxidative stress and neuronal cell death – Catarina Oliveira (Portugal).....................................................................73 Excitotoxicity: glutamate out of the cage – João Malva (Portugal)..............................................................................84 Brain barriers I – Joana Palha (Portugal).....................................................................................................................85 Antiepileptic drug treatment in pregnancy with focus in teratogenicity – Torbjorn Tomsom (Sweden)........................86 Tuberous sclerosis – Sergiusz Jozwiak (Poland)..........................................................................................................96

18 Feb. 09:00-10:00 10:00-11:00 11:30-12:30 14:00-15:00 15:00-16:00 16:30-17:30 17:30-18:30

Astrocyte-neuron homeostasis – Rodrigo Cunha (Portugal)........................................................................................97 Neurogenesis in epilepsy – Helen Scharfman (USA)..................................................................................................98 West Syndrome – Sergiusz Jozwiak (Poland).............................................................................................................99 Brain barriers II – Joana Palha (Portugal)..................................................................................................................100 Caffeine and adenosine receptors in the control of epileptic-like features – Rodrigo Cunha (Portugal).....................117 Antiepileptic drugs and SUDEP – Torbjorn Tomson (Sweden)..................................................................................118 The neurogenic niche dynamics – João Malva (Portugal).........................................................................................128

19 Feb. 08:30-09:30 09:30-10:30 11:00-12:00 14:00-15:00 15:00-16:00 16:30-17:30

Main inborn errors of metabolism – Fernando Kok (Brazil)......................................................................................129 Investigating genetic syndromes: main aspects – Iscia Lopes Cendes (Brazil)...........................................................130 Rett syndrome – Jaime Carrizosa Moog (Colombia).................................................................................................140 Angelman syndrome – Kette Valente (Brazil)...........................................................................................................145 Seizures in Alzheimer Disease – Helen Scharfman (USA)........................................................................................164 Neuroimaging in brain malformations related to epilepsy – Fernando Cendes (Brazil).............................................165

20 Feb. 08:30-09:30 09:30-10:30 11:00-12:00 14:00-15:00 15:00-16:00 16:30-17:30

Epilepsy in autoimmune encephalitis – Maria Chiara Stefanini (Italy)......................................................................193 Encephalopathy related to Status Epilepticus during Sleep (ESES) – Carlo Alberto Tassinari (Italy) ...........................194 Dravet Syndrome – Elza Marcia Yacubian (Brazil) ...................................................................................................195 PME – Jesus Machado-Salas (USA)..........................................................................................................................207 Focal epilepsies: progressive disorders? – Fernando Cendes (Brazil)........................................................................221 First Seizure Management – Diagnostic and treatment algorithm in late onset epilepsies – Bernard Pohlmann-Eden (Canada).................................................................................................................................................................238 17:30-18:30 Characteristics of epilepsy in adult and aged women – Patricia Braga (Uruguay.....................................................266)

21 Feb. 08:30-09:30 09:30-10:30 11:00-12:00 14:00-15:00 15:00-16:00 16:30-17:30 20:00-21:30

Status epilepticus-induced epilepsy: experimental observations – João Pereira Leite (Brazil)....................................280 Approach to medically resistant epilepsy – Cigden Ozkara (Turkey)........................................................................281 Epilepsy surgery and presurgical evaluation – Cigden Ozkara (Turkey)....................................................................282 FIREs – Roberto Caraballo (Argentina).....................................................................................................................283 Which really matters: the etiology or the spikes? – Alicia Bogacz (Uruguay)............................................................292 Does some MTLE represent a progressive degenerative disorder? – Roberto Spreafico (Italy)...................................298 ALADE Conference: Neurodegenerative diseases: the look of a pediatric neurologist – Jaderson Costa da Costa (Brazil)...........................................................................................................................................................308

22 Feb. 09:00-10:00 The Struldbruggs and neurodegeneration – Marina Bentivoglio (Italy.....................................................................309) 10:00-11:00 What do we know about the neurobiology of cognitive decline in “normal” aging and in neurodegenerative diseases?

– Giuseppe Bertini (Italy).........................................................................................................................................310 11:30-12:30 Brain aging and neuroplasticity – Marina Bentivoglio (Italy)....................................................................................311 14:00-15:00 Cognitive and brain changes in asymptomatic persons at increased risk for Alzheimer’s disease – Bruce Hermann (USA)......................................................................................................................................................................312 15:00-16:00 Seizures and dementia in Down’s syndrome – Laura Guilhoto (Brazil)....................................................................327 16:30-17:30 Classification of status epilepticus – Guilca Contreras (Venezuela)..........................................................................349 17:30-18:30 Electroencephalographic status epilepticus – Luis Otávio Caboclo (Brazil)..............................................................360 23 Feb. 08:30-09:30 09:30-10:30 11:00-12:00 14:00-15:00 15:00-16:00

Translational research: Finding a better drug for epilepsy – Astrid Nehlig (France)...................................................397 Neuropsychological and brain changes in aging persons with chronic epilepsy – Bruce Hermann (USA)................408 Psychiatric effects of AEDs – Andres Kanner (USA)..................................................................................................424 Acute treatment of epilepsy – Peter Wolf (Denmark)................................................................................................425 Transcranial magnetic stimulation in epilepsy refractory to drug treatment – Lilia Morales Chacon (Cuba)..............432

24 Feb. – Surgical approach of the epilepsies 08:30-09:30 The need for presurgical evaluation – Silvia Kochen (Argentina)..............................................................................444 09:30-10:30 Surgery in tuberous sclerosis complex – Hélio Rubens Machado (Brazil)................................................................456 11:00-12:00 Surgery in focal cortical dysplasias – Manuel Campos (Chile).................................................................................463 12:00-13:00 Surgery in PWE older than 50 years – Mario Alonso (Mexico).................................................................................464 25 Feb. – Group presentations 09:00-18:00 Presentations + coffee-breaks + lunch 20:00 Farewell dinner

Peter Wolf (Denmark)

CONCEPT OF FOCAL AND GENERALIZED ICTOGENESIS

6

7

8

9

10

11

12

13

14

15

16

17

18

19

Loreto Rios (Chile)

NEONATAL SEIZURES

20

21

22

23

24

25

26

27

28

29

30

31

Vera Terra (Brazil)

SEIZURES IN CHILDHOOD

32

33

34

35

36

37

38

39

40

41

42

43

44

45

46

Elza Marcia Yacubian (Brazil)

SEIZURES IN ADULTS

47

48

49

50

51

52

53

54

55

56

57

58

59

60

61

62

63

64

65

66

67

68

69

70

Tonicarlo Velasco (Brazil)

SEIZURES IN THE ELDERLY

71

João Malva (Portugal)

NEURONAL DEATH: DIFFERENT PATHS TO THE SAME FATE

72

Catarina Oliveira (Portugal)

OXIDATIVE STRESS AND NEURONAL CELL DEATH

73

74

75

76

77

78

79

80

81

82

83

João Malva (Portugal)

EXCITOTOXICITY: GLUTAMATE OUT OF THE CAGE

84

Joana Palha (Portugal)

BRAIN BARRIERS I

85

Torbjorn Tomson (Sweden)

ANTIEPILEPTIC DRUG TREATMENT IN PREGNANCY WITH FOCUS IN TERATOGENICITY

86

87

88

89

90

91

92

93

94

95

Sergiusz Jozwiak (Poland)

TUBEROUS SCLEROSIS

96

Rodrigo Cunha (Portugal)

ASTROCYTE-NEURON HOMEOSTASIS

97

Helen Scharfman (USA)

NEUROGENESIS IN EPILEPSY

98

Sergiusz Jozwiak (Poland)

WEST SYNDROME

99

Joana Palha (Portugal)

BLOOD-BRAIN BARRIERS II

100

101

102

103

104

105

106

107

108

109

110

111

112

113

114

115

116

Rodrigo Cunha (Portugal)

CAFFEINE AND ADENOSINE RECEPTORS IN THE CONTROL OF EPILEPTIC-LIKE FEATURES

117

Torbjorn Tomson (Sweden)

ANTIEPILEPTIC DRUGS AND SUDEP

118

119

120

121

122

123

124

125

126

127

João Malva (Portugal)

THE NEUROGENIC NICHE DYNAMICS

128

Fernando Kok (Brazil)

MAIN INBORN ERRORS OF METABOLISM

129

Iscia Lopes Cendes (Brazil)

INVESTIGATING GENETIC SYNDROMES: MAIN ASPECTS

130

131

132

133

134

135

136

137

138

139

Jaime Carrizosa Moog (Colombia)

RETT SYNDROME

140

141

142

143

144

Kette Valente (Brazil)

ANGELMAN SYNDROME

145

146

147

148

149

150

151

152

153

154

155

156

157

158

159

160

161

162

163

Helen Scharfman (USA)

SEIZURES IN ALZHEIMER’S DISEASE

164

Fernando Cendes (Brazil)

NEUROIMAGING IN BRAIN MALFORMATIONS RELATED TO EPILEPSY

165

166

167

168

169

170

171

172

173

174

175

176

177

178

179

180

181

182

183

184

185

186

187

188

189

190

191

192

Maria Chiara Stefanini (Italy)

EPILEPSY IN AUTOIMMUNE ENCEPHALITIS

193

Carlo Alberto Tassinari (Italy)

ENCEPHALOPATHY RELATED TO STATUS EPILEPTICUS DURING SLEEP (ESES)

194

Elza Mรกrcia Yacubian (Brazil)

DRAVET SYNDROME

195

196

197

198

199

200

201

202

203

204

205

206

Jesus Machado Salas (USA)

PME

207

208

209

210

211

212

213

214

215

216

217

218

219

220

Fernando Cendes (Brazil)

FOCAL EPILEPSIES: PROGRESSIVE DISORDERS?

221

222

223

224

225

226

227

228

229

230

231

232

233

234

235

236

237

Bernd Pohlmann-Eden (Canada)

FIRST SEIZURE MANAGEMENT - DIAGNOSTIC AND TREATMENT ALGORITHM IN LATE ONSET EPILEPSIES

238

239

240

241

242

243

244

245

246

247

248

249

250

251

252

253

254

255

256

257

258

259

260

261

262

263

264

265

Patricia Braga (Uruguay)

EPILEPSY IN ADULT AND AGED WOMEN

266

267

268

269

270

271

272

273

274

275

276

277

278

279

João Pereira Leite (Brazil)

STATUS EPILEPTICUS-INDUCED EPILEPSY: EXPERIMENTAL OBSERVATIONS

280

Cigden Ozkara (Turkey)

APPROACH TO MEDICALLY RESISTANT EPILEPSY

281

Cigden Ozkara (Turkey)

EPILEPSY SURGERY AND PRESURGICAL EVALUATION

282

Roberto Caraballo (Argentina)

FIRES

283

284

285

286

287

288

289

290

291

Alicia Bogacz (Uruguay)

WHICH REALLY MATTERS: THE ETIOLOGY OR THE SPIKES?

292

293

294

295

296

297

Roberto Spreafico (Italy)

DOES SOME MTLE REPRESENT A PROGRESSIVE DEGENERATIVE DISORDER?

298

299

300

301

302

303

304

305

306

307

Jaderson Costa da Costa (Brazil)

ALADE CONFERENCE: NEURODEGENERATIVE DISEASES: THE LOOK OF A PEDIATRIC NEUROLOGIST

308

Marina Bentivoglio (Italy)

THE STRULDBRUGGS AND NEURODEGENERATION

309

Giuseppe Bertini (Italy)

WHAT DO WE KNOW ABOUT THE NEUROBIOLOGY OF COGNITIVE DECLINE IN NORMAL “AGING” AND IN NEURODEGENERATIVE DISEASES?

310

Marina Bentivoglio (Italy)

BRAIN AGING AND NEUROPLASTICITY

311

Bruce Hermann (USA)

COGNITIVE AND BRAIN CHANGES IN ASYMPTOMATIC PERSONS AT INCREASED RISK FOR ALZHEIMER’S DISEASE

312

313

314

315

316

317

318

319

320

321

322

323

324

325

326

Laura Guilhoto (Brazil)

SEIZURES AND DEMENTIA IN DOWN’S SYNDROME

327

328

329

330

331

332

333

334

335

336

337

338

339

340

341

342

343

344

345

346

347

348

Guilca Contreras (Venezuela)

CLASSIFICATION OF STATUS EPILEPTICUS

349

350

351

352

353

354

355

356

357

358

359

Luis Otรกvio Caboclo (Brazil)

ELECTROENCEPHALOGRAPHIC STATUS EPILEPTICUS

360

361

362

363

364

365

366

367

368

369

370

371

372

373

374

375

376

377

378

379

380

381

382

383

384

385

386

387

388

389

390

391

392

393

394

395

396

Astrid Nehlig (France)

TRANSLATIONAL RESEARCH: FINDING A BETTER DRUG FOR EPILEPSY

397

398

399

400

401

402

403

404

405

406

407

Bruce Hermann (USA)

NEUROPSYCHOLOGICAL AND BRAIN CHANGES IN AGING PERSONS WITH CHRONIC EPILEPSY

408

409

410

411

412

413

414

415

416

417

418

419

420

421

422

423

Andres Kanner (USA)

PSYCHIATRIC EFFECTS OF AEDS

424

Peter Wolf (Denmark)

ACUTE TREATMENT OF EPILEPSY

425

426

427

428

429

430

431

Lilia Morales Chacon (Cuba)

TRANSCRANIAL MAGNETIC STIMULATION IN EPILEPSY REFRACTORY TO DRUG TREATMENT

432

433

434

435

436

437

438

439

440

441

442

443

Silvia Kochen (Argentina)

THE NEED FOR PRESURGICAL EVALUATION

444

445

446

447

448

449

450

451

452

453

454

455

Hélio Rubens Machado (Brazil)

SURGERY IN TUBEROUS SCLEROSIS COMPLEX

456

457

458

459

460

461

462

Manuel Campos (Chile)

SURGERY IN FOCAL CORTICAL DYSPLASIAS

463

Mario Alonso (Mexico)

SURGERY IN PWE OLDER THAN 50 YEARS

464

Organização:

Instituto Nacional de Neurociência Translacional

Apoio:

HUG-CELL CEPID