REDMO
2009
Annual Report
VOLUNTARY DONORS •
Available typed donors on December 31st, 2009
80314
Donors typed in 2009: 9539
90000 80000
Registered donors
70000 60000 50000 40000 30000 20000 10000 0 1993
1995
1997
1999
2001
2003
2005
2007
2009
Donors per Autonomous Community Typed Autonomous Community Donors Andalucía 12758 Aragón 1113 Asturias 2138 Baleares, Islas 1502 Canarias, Islas 4210 Cantabria 493 Castilla y León 5262 Castilla – La Mancha 2250 Catalunya 13563 Comunidad Valenciana 7786 Extremadura 3067 Galicia 1990 Madrid 8534 Murcia 5819 Navarra 5294 País Vasco 3724 Rioja, La 537 Ciudad Autónoma de Ceuta 96 Ciudad Autónoma de Melilla 39 Andorra 139 Total 80314
x 100.000 hab. 153.66 82.72 197.00 137.12 200.10 83.67 205.26 108.10 181.43 152.83 278.21 71.17 133.62 402.28 839.55 171.44 166.92 122.02 53.09 NA
2
VOLUNTARY DONORS •
1474
Donors cancelled during 2009 Reasons for donor cancellation Older than 55 years Disease Non traceable Voluntary Transfer to other registries Effective peripheral blood donation Decease Ethical reasons Other reasons
•
1173 106 63 55 24 30 13 11 8 39
Effective Hematopoietic Stem Cells Donors Per product Bone marrow Peripheral blood stem cells (lymphocyte donation) Collection Centres BM/PBSC Hospital BM Centro Hospitalario Ramón y Cajal 2 Hospital Gregorio Marañón 1 Hospital de la Princesa 2 Hospital Puerta de Hierro 0 Hospital Carlos Haya 0 Hospital de Navarra 1 Complejo Hospitalario de Santiago 0 Hospital Virgen de la Arrixaca 0 Hospital de Jerez de la Frontera 1 Hospital Clínico de Valencia 1 Hospital Clínico d Salamanca 0 Hospital Dr. Negrín 0 Hospital Son Dureta 0 Hospital Central de Asturias 0 Hospital Virgen del Rocío 1 Hospital Xeral-Cies 0 Centre de Transfusió i Banc de Teixitis 0 Total 9
9 30 (2)
PBSC 2 4 2 2 4 1 1 1 0 0 4 2 2 1 1 1 2 30
Total 4 5 4 2 4 2 1 1 1 1 4 2 2 1 2 1 2 39
3
UMBILICAL CORD BLOOD •
Available Cord Blood Units on December 31st, 2009 41771
45000
CBU cryopreserved in 2009: 6404
41 771
40000 35000
36005
30000 28801 25000
24462
20000
20732 17421
15000
15271 12566
10000 5000
10877 7779 793
2029
4668
0 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009
CBU – Cord blood bank distribution Cord Blood Bank Malaga Castilla-La Mancha: 312 Barcelona Navarra:682 Extremadura:256 Aragón:305 Islas Baleares:185 Cantabria:63 Galicia Castilla y León: 66 Madrid La Rioja: 7 Valencia Tenerife
14613
TNC >1x109 45%
CD34+ Available 59-3%
12880
69%
99.6%
5234
31%
98.1%
5343
58%
88.6%
3245 456
54% 34%
96.6% 26.3%
Number
4
UMBILICAL CORD BLOOD •
229
Spanish CBU transplanted during 2009
Per banks of origin Total National Patients 142 (62%) 41 26 (11%) 9 31 (14%) 3 13 (6%) 0 15 (6%) 3 2 (1%) 0 229 56
Bank of origin Barcelona Madrid Malaga Galicia Valencia Tenerife Total
International Patients 101 17 28 13 12 2 173
1400
Total Spanish donations n= 1264 1200
CBU (n= 966) 1000
PBSC (n= 197) 800
BM (n= 153)
600 400 200 0 '94
'95
'96
'97
'98
'99
'00
'01
'02
'03
'04
'05
'06
'07
'08
'09
5
NATIONAL PATIENTS A. Started Searches •
687
Searches initiated during 2009 Type of search Bone marrow / Peripheral blood stem cells Cord blood Bone marrow / Peripheral blood stem cells and cord blood
143 10 534
Started evolution searchesfor Spanish patients
700
Searches initiated in 2009: 687
600
CBU
500
PBSC/BM + CBU
400
PBSC/BM
300
200
100
0 1991
1993
1995
1997
1999
2001
2003
2005
2007
2009
6
NATIONAL PATIENTS Searches initiated according to patient’s residence Autonomous Community Number x100.000 hab Catalunya 138 1.85 Andalucía 98 1.18 Madrid 88 1.38 Comunidad Valenciana 68 1.33 Galicia 42 1.5 Asturias 38 3.5 Murcia 36 2.49 Castilla y León 33 1.29 País Vasco 29 1.34 Islas Canarias 25 1.19 Castilla – La Mancha 16 0.77 Cantabria 15 2.55 Navarra 14 2.22 Aragón 11 0.82 Islas Baleares 11 1 Extremadura 9 0.82 La Rioja 9 2.8 Ciudad Autónoma de Ceuta 2 2.54 Ciudad Autónoma de Melilla 2 2.72 Overseas 3 NA
Searches initiated according to Diagnosis Acute Myeloblastic Leukaemia Acute Lymphoblastic Leukaemia Non Hodgkin Lymphoma Myelodisplastic Syndrome Severe Aplastic Anaemia Chronic Myeloid Leukaemia Hodgkin Lymphoma Inherited Erythrocyte Diseases Other Leukaemia Other Malignancies Plasma Cell Disorders Inherited Immune System Diseases / Disorders Histiocytosis Inherited Metabolic Diseases Other non Malignant Diseases
206 138 97 68 33 32 32 21 16 13 12 10 4 3 2
7
NATIONAL PATIENTS Evolution of diagnosis in started searches 250
200
ALL AML 150
CML MDS AMG
100
Lymphomas Cong. Dis 50
0 2002
2003
2004
2005
2006
2007
2008
2009
Mean age of started searches
40 37
age
35 33
30
30
25 20
22
23
25 24 26
34
31
27 28
21
15 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09
year 8
NATIONAL PATIENTS •
CBU Selections performed by REDMO Office (September - December)
40
•
Active searches on January 1st , 2009
236
•
Active searches on December 31st, 2009
251
•
Cancelled searches during 2009
661
Reasons for search cancellation Unrelated transplantation National rules (See detailed information below) Exitus Clinical status Related transplantation Unrelated lymphocyte infusion Autologous transplantation Other (modification HLA typing, different therapy, transfer to other registries) Patient decision •
356 118 106 47 16 8 5 4 1
Detailed information about cancelled searches according to national rules Suspended searches for >1 year without eligible donor Suspended searches for >1 year with eligible donor Active searches for more than 2 years Active searches between <1 and >2 years
1* 52 21 44
* Search previously deactivated due to patient’s clinical status, pending medical evaluation.
•
Suspended searches on December 31st, 2009
216
Reasons for search suspension Eligible donor found Selected CBU (data of infusion pending) Clinical status Different therapy
200 11 2 1
9
NATIONAL PATIENTS B. Compatible donors found •
Patients with one or more eligible donor(s) found (BM/PBSC)
450
•
Donors found during 2009 (BM/PBSC)
682
•
Mean period of time in which BM/PBSC searches are deactivated after donor found (days) Standard deviation: ±116.16
88.3
•
50
Median search duration in 2009 (days) Extremes: 7 y 882
Time to find BM/PBSC donor expressed in percentages Less than 3 months Between 3 and 6 months Between 6 and 10 months Between 10 and 12 months More than 12 months
77.74 12.29 4.64 1.85 3.48
Evolution of total number of donors found 700
Compatible donors found in 2009: 682
600
500
400
300
200
100
0 1993
1995
1997
1999
2001
2003
2005
2007
2009
10
NATIONAL PATIENTS Actuarial probability of 7/8 or 8/8 donor
Median time to find a donor (BM/PBSC)
11
NATIONAL PATIENTS C. Transplants •
356
Hematopoietic stem cells transplants performed during 2009 According to product
Bone marrow Peripheral blood stem cells Umbilical cord blood (ilymphocyte infusion)
78 145 133 (8)
Evolution of performed transplants
Transplants performed in 2009: 356
400 350
CBU (n= 133)
300
PBSC (n= 145)
250
BM (n= 78)
200 150 100 50 0 1993
1995
1997
1999
2001
2003
2005
2007
2009
12
NATIONAL PATIENTS Transplants according to coutry of origin BM/PBSC Germany United States Spain France United Kingdom Italy Australia Denmark Portugal Canada Cyprus The Netherlands Israel Lithuania Czech Republic Sweden
126 50 17 7 6 4 2 2 2 1 1 1 1 1 1 1
Transplants according to coutry of origin CBU * Spain United States France Australia Germany Belgium Italy United Kingdom The Netherlands Czech Republic Switzerland (* 2 double CBU transplants carried out)
56 41 13 7 6 3 3 2 2 1 1
13
Transplants performed per Autonomous Community (2009) Islas Baleares 3 1% Navarra 2 1% Asturias 15 4% País Vasco 5 Andalucia 50 14% 1% Galicia 21 6%
Cantabria 20 6%
Castilla y León18 5%
Valencia 57 16%
Murcia 22 6% Catalunya 93 26% Madrid 50 14%
(n=356) REDMO activity summary (national patients) 6000
Inicial Searches 5000
Eligible donors 4000
Transplants 3000 2000 1000 0
14
INTERNATIONAL PATIENTS •
Performed preliminary searches
•
Activated searches
1253
•
Requested tests
2045
•
Performed tests
1590
15288
Searches initiated for international patients
18000 16000
Activated searches (n= 1 253)
14000
Iniciated searches (n= 15 288)
12000 10000
8000
6000
4000
2000
0 1993
1995
1997
1999
2001
2003
2005
2007
2009
15
INTERNATIONAL PATIENTS •
Hematopoietic stem cell transplants performed Transplants per product Bone Marrow Peripherical Blood Stem Cells Umbilical Cord Blood (lymphocyte infusion) Transplants per country of destination BM/PBSC United States Australia France Germany Italy Austria Belgium Czech Republic United Kingdom Greece Israel Switzerland Transplants per country of destination CBU France United States United Kingdom Germany Israel The Netherlands Canada Italy Greece Colombia Mexico New Zealand Argentina Belgium Australia Bulgary Chile Hungary Ireland Portugal Sweden Turkey
195
3 19 173 (1)
5 4 2 2 2 1 1 1 1 1 1 1
46 43 15 12 8 7 6 6 5 4 4 3 2 2 2 2 1 1 1 1 1 1
16