Tick Tock Club newsletter September 2014 by Great Ormond Street Hospital Children's Charity

neWSleTTeR • SUMMeR/aUTUMn 2014

Welcome

“The club has had an exciting six months and the appeal is gaining momentum, currently standing at just over £3 million.” I am delighted to be able to introduce this latest edition of the Tick Tock Club newsletter my first as the new Chairman of the Tick Tock Club. As you know, the club has been up and running for a number of years, bringing together a network of people who together make a major contribution to Great Ormond Street Hospital by supporting its greatest and most urgent need. Over the past seven years the club has become the largest single donor to the hospital, raising over £23 million – this is a terrific achievement that has only been possible thanks to your generous support. I hope that I can play some part in its continuing success and continue the fantastic work of my predecessors Ken Costa and Huw Jenkins. Our aim is to raise £10 million to provide the hospital, its patients and their families,

and its fantastic staff with a new surgery centre, due to open in 2017. The club has had an exciting six months and the appeal is gaining momentum, currently standing at just over £3 million. I have already been astonished by the outstanding acts of generosity displayed during the last few months, and we have focused on celebrating the extraordinary contributions of some of our most recent members overleaf in the club news section. Many of you will be aware of my motor racing connections through my sons and as Chairman of Carlin. I am pleased to announce that the proceeds from the recent launch party for the FORMULA 1 SANTANDER BRITISH GRAND PRIX in aid of Great Ormond Street Hospital Children’s Charity will be directed towards the new surgery centre, the club’s current appeal, which will boost our coffers.

Cover: Zikora who was rushed to Flamingo Ward when he was just 13 months old

The momentum that the Tick Tock Club has gained is being matched at the hospital. Later this year, the builders begin their work on the Premier Inn Clinical Building, the second part of the Mittal Children’s Medical Centre across which the surgery centre will extend. Importantly, for the hospital’s families and very young patients, there have been remarkable breakthroughs in research work led by the surgery team, which will bring better treatments in their wake. I do hope you enjoy reading about this and more in the following pages. I hope to have the opportunity to meet you at a Tick Tock Club event in the near future. Ever onwards, Chily Grahame Chilton Chairman, the Tick Tock Club

CONTENTS

contents club news The latest news from the Tick Tock Club

Surgery

Our next challenge 06 The Director of Redevelopment explains the unique challenges of rebuilding a working children’s hospital nursing a brighter future The Head of Theatre Nursing describes the difference the new surgery centre will make to the staff who work there

heart and lung

Kidney

advancing surgery through research 10 Mr Neil Bulstrode’s pioneering ear rebuilding work is told through the eyes of Flora, one of his patients Making the difference for children with renal problems Rhees’ dad explains the emotions of donating a kidney to his son

Making the difference for children with heart problems Zikora’s mum, Chenny, tells their amazing story

THE TICK TOCK CLUB NEWSLETTER

CLUB NEWS

Formula 1® party raises money for surgery centre

Above: Entrance to the party at the V&A Museum. Top right: Max Chilton. Bottom right: Tamara Ecclestone

The official launch party for the 2014 FORMULA 1 SANTANDER BRITISH GRAND PRIX took place on 2 July in aid of Great Ormond Street Hospital Children’s Charity and was kindly supported by SHOW Beauty and Tick Tock Club member Tamara Ecclestone. This year’s event was a celebration of the 10th anniversary of the hospital’s very special partnership with Formula 1® in the beautiful surroundings of London’s V&A Museum. The Formula 1® community’s partnership with the hospital has reached from Silverstone – where each year patients and their families are

invited to enjoy a special day out over the Grand Prix weekend – to the hospital’s own operating theatres, where pit teams have helped our clinicians improve patient transfers from surgery to intensive care wards. One of the highlights of this year’s event was a fascinating Q&A involving some famous faces from the world of Formula 1®. Guests also had the opportunity to hear from parent Mari Edwards, whose daughter Meila was successfully treated by the hospital’s surgical team, and who features in our Tick Tock Club appeal brochure.

There was a champagne reception and three-course dinner, a live performance from La Roux, and a live and silent auction with a variety of exciting lots. The money raised at the party will go towards Great Ormond Street Hospital’s new surgery centre.

One of the highlights of this year’s event was a fascinating Q&A involving some famous faces from the world of Formula 1®.

CLUB NEWS

New members help boost the Tick Tock Club total Over the last six months, new and renewed Tick Tock Club memberships have helped boost our appeal total by nearly £850,000. We are so grateful to all those members who have so generously responded to the club’s latest challenge.

The challenge ahead Thank you to all of you who are already supporting the Tick Tock Club. This is the wonderful total you have helped us to raise so far. Our goal of £10 million will enable the hospital to build a new surgery centre to open in 2017. 2017

TARGET

We are delighted to welcome two new sets of members to the Tick Tock Club, who have helped us reach this fantastic total. Andrew and Melanie White are long-standing supporters of Great Ormond Street Hospital. Andrew is directly involved with the Tick Tock Club as a member of the surgery centre appeal board and we are hugely grateful for all his hard work on our behalf. We are also grateful to Andrew for support generated through his company WSM Communications, from which two directors have also pledged membership – Harry Owens and Chris O’Donoghue. Thank you! The Thompson Family Charitable Trust has also generously made a significant contribution towards the new surgery centre, and we are thrilled that they have chosen to become a part of the Tick Tock Club.

10m

Funds required Funds raised

8m 7m 6m 5m 4m

July 2014 January 2014

3m 2m 1m

Appeal Launch

Golf days raise over £500,000 for the Tick Tock Club This year saw our dedicated golf day committee join forces once again, to raise money for the Tick Tock Club. The 2014 golf day, which took place in June on the Old Course at Sunningdale Golf Club, raised money for the new surgery centre appeal. The committee, comprised of Tick Tock Club members Alan Bennie, Alan Hodson, Huw Jenkins, Andrew White and Paul Roy, organised a fabulous day of golf, followed by a champagne reception and lunch. We were lucky enough to

be joined by actor, comedian and presenter Rob Brydon who hosted the event and helped boost the day’s fundraising. We also received generous sponsorship from Speedflex with additional support from Rendall and Rittner, Barclays and Toscafund helping to bring the total raised on the day to over £165,000. This means that, over the past three years, Tick Tock Club golf days have now raised over £500,000 for the hospital. Our thanks to all players and supporters.

Golf day chairman Paul Roy tees off with Alan Hansen

The Tick Tock Club Newsletter

SURGERY

Our next challenge healthcare planners look at how the new facility is going to work and best support the clinical services, not just now, but also in the future. This process ensures that we get the maximum benefits for the long-term out of the investments being made.

Matthew Tulley, Director of Redevelopment

“Good design in hospitals isn’t just about efficiency,” says Matthew, “but also about providing a therapeutic environment for children to recover. For example, access to natural light and artwork can help children feel better and needs to be considered when putting plans together.

Overseeing Great Ormond Street Hospital’s ambitious and complex building programme is a huge challenge. Leading it is Matthew Tulley, Director of Redevelopment, who is excited by the benefits these new buildings will bring “Great Ormond Street Hospital has been on the same site for over 160 years now, which creates clinical challenges as medicine and technology develop,” says Matthew. “It’s my job to work with the clinical staff and look ahead to the next few decades at the services we wish to provide.” The Redevelopment team is split into three groups. The

projects team oversees the work, scoping out the project through to delivering it to the hospital. One example is the recently installed Interventional Radiology Suite above the new reception area. The second team does the commissioning work for new spaces, procuring the equipment and working with the clinical staff to learn how they want to use the new facilities. Finally, the

“Working together with hospital staff and families is key. There is huge engagement and goodwill towards the redevelopment programme, as staff and families can see the enormous difference the Morgan Stanley Clinical Building has made to them. By involving them in the design of the new Premier Inn Clinical Building, we can ensure that we can create a building that works in practice,

“Good design in hospitals isn’t just about efficiency... but also about providing a therapeutic environment for children to recover.”

SURGERY

not just on the architects’ plans. It’s a real challenge for us to make new facilities work for our whole patient population – catering for a baby is very different to producing an environment that a teenager feels comfortable in. “We also look after enabling works, the building projects that enable the hospital to remain open and operational while closing and opening whole new buildings. It’s akin to a slider puzzle where you have a piece missing and need to move everything around to get it in the right order. We’ve just finished a large piece of enabling work that has allowed us to hand over to Skanska, our contractor, to begin work on the Premier Inn Clinical Building. “There are lots of challenges in my job but it’s one I absolutely love. We have a very clear mission at Great Ormond Street Hospital, to care for very ill children, and

Shh... A key challenge of rebuilding Great Ormond Street Hospital is how to do so in a small space where ill children are being cared for. One area impacted by the redevelopment is the amount of noise the contractors can make. “Noise pollution is an area that contractors are increasingly conscious of – they no longer talk about demolition but

“Working together with hospital staff and families is key. There is huge engagement and goodwill towards the redevelopment programme, as staff and families can see the enormous difference the Morgan Stanley Clinical Building has made to them.” I enjoy playing a small part in helping the clinicians carry out the fantastic work they do by providing them with better facilities. We have a really ambitious redevelopment project and it is because of the Tick Tock Club and many other generous donors that we have a realistic ambition of delivering it.” deconstruction,” explains Matthew. “This is particularly important, for example, when we’re creating the new surgery centre, as the building work is taking place right next to existing wards and science laboratories. “The way we deal with this challenge is to put a number of restrictions on the contractor as to when they can do what we refer to as ‘noisy works’. We set limits on noise, dust and vibration levels at certain times of the

The old Cardiac Wing

day. A good example of this collaborative approach is the work we’ve done with the hospital’s imaging department.

“One area impacted by the redevelopment is the amount of noise the contractors can make.” We’ve agreed a timetable of work and they’ve altered their shift patterns so that the ‘noisy works’ have less impact on their vital work with sick children.” THE TICK TOCK CLUB NEWSLETTER

SURGERY

Nursing a brighter future Jilly Hale is Head of Theatre Nursing at Great Ormond Street Hospital. With hundreds of staff under her leadership, she oversees the care of patients from pre-admission through to surgery and post-operative care. Jilly will have a key role in the new surgery centre that the Tick Tock Club is funding What does the Head of Theatre Nursing do? I oversee the whole of the patients’ journey from admission to going home again. It’s my job to have a holistic view of the whole system and act accordingly. For example, the theatre teams are keen to ‘fill the lists’ but we’ll need a post-operative bed for the patient, so it’s my job to look along the whole pathway and make sure it’s all joined up. It’s a challenging role but one that I love. How is theatre nursing different at Great Ormond Street Hospital? The obvious point is that you’re nursing often very young children. This means having to be able to recognise symptoms or warning signs as the patient isn’t able to communicate pain as an adult would. Secondly, you’re nursing the family rather than just the child. Understandably, many parents are very hands-on and want to know everything about the care their child is receiving, so as a nurse you’re really working in a partnership with the whole family unit.

Jilly Hale, Head of Theatre Nursing

SURGERY While many other hospitals do paediatric surgery, the children we see often have very complex conditions so can be a real challenge either anaesthetically or surgically. As a result of the patients’ complications it means that our nurses may not have cared for someone with this very rare condition before. It increases the importance of the training we provide our nurses and their supervision.

“The new surgery centre will increase the space we have to nurse our patients and for them to recover.” How is nursing changing? I think the biggest change over my career is the upskilling of nurses. We now have new roles such as nurse consultants and advanced nurse practitioners carrying out tasks like clerking and prescribing that junior doctors would have done many years ago. To facilitate that change we also employ more healthcare assistants to support their work. How important are facilities when nursing a child who has had surgery? The key ingredient for surgery is space. Surgery requires a lot of bulky equipment and when a child is recuperating on a ward then they’ll also often be attached to large pieces of kit. Currently, our post-operative wards are a real

mixed bag. For example, Peter Pan Ward, which was built over 75 years ago, is very cramped, making it a difficult environment to nurse children in, particularly given the equipment needed around the bed, and it is less pleasant for the children and families, with no room for a parent to stay. The new surgery centre will increase the space we have to nurse our patients in and for them to recover. Not only will the new centre help my team to offer the best possible care but I believe it’ll improve our retention of staff. As mentioned, because we care for children with very complex and rare conditions it’s vital we retain staff who have built up experience. An improved working environment with more space, light and purpose-built facilities will help us to keep nurses for longer. Why is the co-location in the new surgery centre important? Bringing all the surgery units together in one area of the hospital is vital for transferring the patients from theatre to the wards. It’s a very delicate period in a patients’ journey so the shorter it is, the better. Having all the post-operative wards together will also help teams work together, and will create the largest patient bedpool in the hospital.

“Bringing all the surgery units together in one area of the hospital is vital”

Collaboration between specialties is a huge part of what we do at Great Ormond Street Hospital, and having doctors and nurses from different specialties on the same ward together will only improve the holistic care of each child. How important is teamwork in theatres? I think most surgeons realise that they couldn’t do their job alone. Without the scrub nurse getting everything ready or passing them the correct instruments they wouldn’t be able to do their job. It’s the same on the ward: the nurses are the staff members at the bedside all day. As a result, the consultants do rely on them to provide detailed information on how a patient is responding to treatment. With such a large team, how do you keep on top of what your nurses are experiencing on the front line? First, I have always tried to keep up my clinical skills – I still try and do an operating list where I can so I’m literally placing myself in the role of a scrub nurse. Secondly, I try and get around the wards for at least half a day once a week and speak to the nurses and hear any concerns they may have. Finally, I always meet the new starters so I can introduce myself and make it clear that I have an open-door policy. It’s my job to make sure all my nurses have the tools they need to do their job properly. The Tick Tock Club Newsletter

SURGERY

Advancing surgery through research A new study has shown how stem cells could pose a viable alternative to current approaches to facial cartilage reconstruction such as ear and nose reconstruction Great Ormond Street Hospital has an excellent track record of successfully treating children born with a malformed or missing ear, a condition known as microtia. The two-stage ear reconstruction takes cartilage from the patient’s ribs, and uses it to mould a new scaffold that is placed beneath the skin. Both the clinical and cosmetic results of this procedure have been very good. However, as Dr Patrizia Ferretti, Head of the Developmental Biology Unit at the UCL Institute of Child Health and her co-authors demonstrate

in their study, undertaken at the Newlife Birth Defects Research Centre, the potential application of human stem cells and tissue engineering could further improve results. These findings would prevent the need for this invasive part of the procedure, which leaves a permanent defect in the patient’s chest. Dr Ferretti explains: “We used stem cells harvested from the abdominal tissue of young patients affected by craniofacial conditions to explore, in our laboratories, how these might be used in future surgery. The use of stem cells from the patients themselves circumvents the issue of rejection and would overcome the need for drugs to suppress the immune system.”

“Great Ormond Street Hospital has an excellent track record of successfully treating patients born with a malformed or missing ear”

Mr Bulstrode with Flora (centre)

Mr Neil Bulstrode, Consultant Plastic Surgeon at the hospital and an author on the paper, said: “It is such an exciting prospect with regard to the future treatment of these patients and many more. Currently, I take the rib cartilage from the chest to make an ear, but if we could produce a block of cartilage using stem cells and tissue engineering, it would be the Holy Grail for our field.”

SURGERY

“During the six months’ wait for second stage surgery, my mum did question whether I really wanted any more operations. My ear looked great as it was and I was made aware of the risks. However, I was determined to

“Surgery really has changed my life. Beforehand, I was self-conscious... now I feel much more confident.”

Flora’s story “When I was born, my mum was very worried because my condition hadn’t been diagnosed during pregnancy and none of the local doctors could tell her what I had. After seeking advice, my mum decided to postpone making a decision about my ear in the hope that better techniques could be developed and I could be part of the process. “Around the age of seven I didn’t want to consider surgery. I didn’t think the result would outweigh the trauma and risk. However, I did have problems at school with people calling me hurtful names, which made me more conscious of my ear.

“On Facebook my mum found a group called Microtia Mingle UK, which had pictures of children who had had surgery. We were both really impressed with the results so we asked our local doctor to refer us.

Flora’s newly created ear

“We had our first appointment with Mr Bulstrode in April 2012 and it was a great relief to have all my questions answered and see pictures of equivalent surgery.

carry on and I had the second operation in December 2012. It was very nerve-wracking, but I’m sure I’ve got the best result possible because Mr Bulstrode put all his knowledge and attention to detail into creating my ear.

“Due to a cancellation I had my first operation only a month later. When the first-stage surgery was over I thought my ear wasn’t the same colour and it looked different. But by the summer the scar had lessened and I was impressed beyond words. I couldn’t wait for the next stage.

“I recently presented Mr Bulstrode with the Child and Family Award. I was delighted to do so as the surgery really has changed my life. Beforehand, I was self-conscious and worried about how people would view my ear: would I get a boyfriend with just one ear? Now I feel much more confident.” The Tick Tock Club Newsletter

KIdNEY

Making the difference for children with renal problems Great Ormond Street Hospital can now transplant kidneys from blood group incompatible donors, thanks to a new method that strips a patient’s blood of antibodies (proteins) before they have the transplant Dr Stephen Marks, a Consultant Paediatric Nephrologist and Clinical Lead for the kidney transplant programme at Great Ormond Street Hospital, said: “When a child has severe irreversible kidney disease, a kidney transplant offers the best quality of life. There are about 140 paediatric kidney transplants per year in the UK and GOSH is the largest centre performing the greatest number of kidney transplants in children. In most cases, a parent or member of the family will come forward as a potential living donor to donate one of their kidneys as this gives the best outcomes for a child. However, sometimes they are unable to do so for personal or medical reasons. For example, if the parent is diabetic, then they cannot donate a kidney. One of the first tests we do is to check

potential donor’s blood groups as historically around 40 per cent of parents have been unable to donate a kidney to their child for this reason.

“Thanks to this new method, it’s not the end of the line.” “In the past, parents were surprised when they were told that their blood group was incompatible as they assume that they would be able to donate. However, thanks to a new method, it is now possible to use blood group incompatible kidneys. Techniques have now been developed that allow blood group antibodies to be removed in some patients before the transplant. These include different types of ‘plasma exchange’ –

which allows the removal of plasma from the blood – to be replaced with new plasma. By removing the plasma, antibody levels in the blood fall. Following their transplant surgery, children are able to recuperate in the beautiful Eagle Ward, which the Tick Tock Club so generously helped to fund.” Four patients have already received these types of ‘incompatible’ transplants since the hospital started carrying them out in 2010 including Rhees, opposite. Dr Stephen Marks, Consultant Paediatric Nephrologist

KIdNEY

The greatest gift Rhees’ mum and dad, Kelly and Jay, first realised he would be born with kidney problems at their second pregnancy scan. However, the extent of the problems were only truly realised when Rhees was rushed to Great Ormond Street Hospital in an ambulance at just one day old. After a series of test results, he was diagnosed as suffering from kidney failure and spent his first six weeks of life in the hospital. The waiting game for Rhees to grow old enough to have a kidney transplant had begun. “The whole family had tests to see who was compatible,” says Kelly. “We all found it really strange that neither his dad nor I were compatible, but fortunately my auntie was, and she volunteered to do it. Sadly, when she had further tests, her blood pressure was found to be too high to have the transplant – it was a real blow.” “It was at this moment that the option of an incompatible match was introduced to us,” says Jay. “They said it’d been done plenty of times in adults but we’d be one of the first to do it for children. As the closer match of the two of us I didn’t hesitate to volunteer. In fact, I was proud to be able to help in some way.” Both operations, to remove and insert the kidney, went well. However, soon after, it all started to go wrong, as Kelly explains: “Jay got an infection from his

stitches and Rhees started to reject the kidney. Trying to look after both of them in different hospitals, as well as my other two children, was the hardest time of my life. Rhees’ rejection of the kidney was causing him serious health problems, so the doctors said they’d remove it the following week, but they’d make one last try with some anti-rejection drugs. Thankfully, the last attempt worked and his results improved week by week. He’s been living well with Jay’s kidney ever since.” “We just hope that my kidney lasts as long as it can and they find further treatments before then,” says Jay. “I’m really proud that a part of me is helping keep my little boy alive. We’ll forever be in debt to the doctors at the hospital who

Rhees with his mum and dad

“I’m really proud that a part of me is helping keep my little boy alive.” developed this new treatment and kept him going. He’s such a bright little boy now – it’s a wonderful thing to see.” THE TICK TOCK CLUB NEWSLETTER

Heart and lung

Making the difference for children with heart problems Zikora was rushed to Flamingo Ward (the Cardiac Intensive Care Unit at Great Ormond Street Hospital, which the Tick Tock Club helped to fund) when he was just 13 months old. His mum Chenny tells his story “Zikora’s first year was perfectly normal – he was a bubbly and cheeky character. However, in October 2012, he was very restless one morning and was agitated. I decided to take him to my local GP to be safe. “As soon as the GP saw him he said: ‘Do you drive? We need to get him to hospital straight away.’ I was so scared – I wasn’t in a fit state to

drive. So they got an ambulance to take us to the local A&E. When we arrived at Newham Hospital it was apparent how serious it was, as there were so many staff waiting for us. Almost upon arrival Zikora had his first cardiac arrest – it was a dreadful moment. He was changing colour and deteriorating very quickly. It was surreal, I felt like I was watching an episode of Casualty.

“We were flying through London... on blue lights. This was only a few hours after I first noticed he was ill.” “The consultant then said Zikora needed to be rushed to Great Ormond Street Hospital by the Children’s Acute Transport Service. I knew that they cared for very ill children so it only confirmed how serious the situation was. Before

Heart and lung I knew it, we were flying through London in an ambulance on blue lights. This was only a few hours after I first noticed he was ill. “Arriving at Flamingo Ward he was placed on an extracorporeal membrane oxygenation (ECMO) machine. It uses an artificial lung to put oxygen into the blood and pump it around the body. Putting Zikora on the machine bought him some time to let them do the necessary tests. Within hours they’d found he had contracted a virus that was causing inflammation of the heart muscles, which caused his heart to collapse. “The next few weeks were incredibly stressful as they tried to battle the virus. However, Zikora wasn’t shaking it off and eventually they had to put him on a Berlin Heart (artificial heart), but he had problems on that as well. He really was terribly ill: we were living day

by day and his different organs were failing. They decided to fit another Berlin Heart, as he wasn’t reacting well to the first one. However, during the changeover he showed signs of recovery. The little fighter started to recover. “Over the coming days and weeks Zikora started to get better, it really was a miracle to see. Having lived at the hospital for over two months we were discharged on Christmas Eve 2012. It’s not been completely plain sailing since he left as he had a stroke last November that was linked to his initial heart problems. However, he’s recovered remarkably well.

Thank you for your support – your membership of the Tick Tock Club has made a huge difference to our patients, their families and our world-class staff.

“I can’t thank the hospital enough. I call Dr Fenton, who looked after us at the hospital, my husband because I love him so much. He was brilliant at calming me down. I’ll forever be indebted to the hospital that saved my little boy.”

As this newsletter highlights, we aim to build on the Tick Tock Club’s fantastic achievements through the creation of a new state-of-theart surgery centre within the Mittal Children’s Medical Centre. This will allow us to continue pushing the boundaries of what’s possible in paediatric surgery and provide the best outcomes possible for our young patients.

“10 years ago, children as sick as Zikora would have died as the technology just did not exist. Supporting the heart with mechanical pumps is, sadly, a regular occurrence here. The use of this pioneering technology has helped buy time for children to recover or to receive a life-saving heart transplant. In fact, last year, the hospital performed its 500th heart and lung transplant which shows just how far we have come.” Dr Matthew Fenton, Consultant Paediatric Cardiologist

If you would like more information on the stories within this newsletter, or would like to learn more about the Tick Tock Club, please contact Heather Roberts, Appeal Manager, at ticktockclub@gosh.org or by telephone on 020 7239 3133.0 Dr Fenton

7239 3133.

The Tick Tock Club Newsletter

Our Tick Tock Club members We are sincerely grateful to our Patron, Gary Lineker OBE, Chairman, Grahame Chilton, and the Tick Tock Club members, including those who wish to remain anonymous. On behalf of the inspiring patients and the remarkable staff at the hospital, thank you 4 Charity Foundation Mr and Mrs Terence Adams Nick and Kate Austin Mr Tony Ball The Barclay Foundation Mr and Mrs Peter Beckwith The Beecham Family Alan and Sara Bennie Emily and Len Blavatnik Mr Bobrovnikov and Mrs Chernavskaya The Bunting Family John and Susan Burns Jason and Belinda Chaffer Mr and Mrs Joe Chambers CB Richard Ellis Sir Trevor and Lady Chinn John Coldman Mr and Mrs Ken Costa The Peter Cruddas Foundation The DG Charitable Settlement Dr Genevieve and Mr Peter Davies Ian and Penny Davis Sarah and Lloyd Dorfman Alex and Tara Easton Tamara Ecclestone André Elshout and Mike Elms The Entertainer Michael and Francesca Evans FDD International Ltd Dorothée and Pierre-Henri Flamand Gary and Catherine Grant Constance Green Foundation Charles and Kaaren Hale Robert Hall Foundation Mrs R E Heale The Higgins Family

The Hobson Charity Limited Alan and Christiane Hodson Brette and Gordon Holmes Steve Jacobs David and Elizabeth James Huw Jenkins The Jenkins Family Philip King Charitable Trust Nick and Linda Johnston Rose Marie and Erland Karlsson Mr and Mrs Nagi R Kawkabani The Lake House Foundation Jude Law Jason Leonard OBE Eugène and Stephanie Léouzon Keith and Muriel Lipman The Lotus Foundation Gavin and Luise MacDonald Charly Malek and Alessandra Steinherr Charles and Sophia Mason The Maaike McInnes Charitable Trust Matt and Emma Scott and Suling Mead George Michael and Kenny Goss Mitch and Alison Moore Hilton and Louise Nathanson Fiona and Andrew Neale Andrew and Marina Newington Christopher and Emily O’Donoghue Amicia and Richard Oldfield Mr and Mrs Harry Owen Elizabeth and Daniel Peltz Simon Picken QC and Dr Sophie Picken Paul Pindar Gilberto Pozzi Alexandra Raphael and Family

The Reuben Foundation Jane and Nick Robinson Stuart and Bianca Roden The Rothermere Foundation The Countess of Rothes The Dr Mortimer and Theresa Sackler Foundation The Basil Samuel Charitable Trust The Sareen Foundation Ian and Carol Sellars Osman and Claudia Semerci The Shanly Foundation John Sibree and family Dominic Shorthouse Standard Chartered plc Sir Hugh and Lady Stevenson Robert Stirling Lord Sugar and Lady Sugar Bobbi Hernandez and Morgan Sze Andrew and Katrina Taee The Taylor Family Foundation Chris and Carole Taylor The Thompson Family Charitable Trust Richard and Susan Thornton – The Thornton Foundation Stanley and Beatrice Tollman Laura and Barry Townsley The Toy Trust Amanda and Dominic Vail CT van Hoorn Charitable Trust Vivid Imaginations Garfield Weston Foundation Michael and Rachel Weston Mr and Mrs Andrew White Mr and Mrs Roger Wyatt

We are also extremely grateful to our benefactors who have kindly supported the Tick Tock Club Great Ormond Street Hospital Children’s Charity. Registered charity number 235825.