EFFECTIVENESS OF A NOVEL
MULTICOMPONENT MYCOTOXIN
DETOXIFICATION AGENT IN THE PRESENCE
1Faculty of Veterinary Medicine, University of Belgrade, Serbia
2Patent Co., DOO, Vlade Ćetkovića, Mišićevo, Serbia
3Institute for Science Application in Agriculture, Belgrade, Serbia
Stefanović, D.; Marinković, D.; Trailović, S.; Vasiljević, M.; Farkaš, H.; Raj, J.; Tolimir, N.; Radulović, S.; Nešić, V.; Trailović, J.N.; et al. Evaluation of Effectiveness of a Novel Multicomponent Mycotoxins
Detoxification Agent in the Presence of AFB1 and T‑2 Toxin on Broiler Chicks. Microorganisms 2023, 11, 574. https://doi.org/10.3390/microorganisms11030574
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TDarko Stefanović1, Darko Marinković1, Saša Trailović1, Marko Vasiljević2, Hunor Farkaš2, Jog Raj2, Nataša Tolimir3, Stamen Radulović1, Vladimir Nešić1, Jelena Nedeljković Trailović1 and Branko Petrujkić1
OBJECTIVE
This experimental study was conducted to determine the ability of a novel mycotoxin detoxification agent (MycoRaid) at a concentration of 0.2% to reduce the toxicity of aflatoxin B1 (AFB1) or T‑2 toxin, alone or in combination, and to examine its effect on:
Performance
Pathohistological changes
Presence of residues of these toxins in the tissues of broiler chicks
Pathohistological changes
Performance
Presence of residues of AFB1 and T-2 toxin in tissues
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AFB1 0,2% T 2 toxin
MATERIALS & METHODS
A total of 96 broiler chicks were divided into eight equal groups:
Group C: this group served as a control (without any additives).
Group MR: this group received the novel detoxification agent, MycoRaid (MR) at a concentration of 0.2%.
Group E‑I: this group received a diet containing 0.1 mg AFB1/kg of feed.
Group E‑II: this group received a diet containing 0.1 mg AFB1/ kg of feed + MR 0.2%.
Group E‑III: this group received a diet containing 0.5 mg T-2 toxin/kg of feed.
Group E‑IV: this group received a diet containing 0.5 mg T-2 toxin/kg of feed + 0.2% MR.
Group E‑V: this group received a diet with a combination of 0.1 mg AFB1/kg of feed and 0.5 mg T-2 toxin/kg of feed.
Group E‑VI: this group received a diet with a combination of 0.1 mg AFB1/kg of feed and 0.5 mg T-2 toxin of feed + 0.2% MR.
Diet with 0.1 mg AFB1/kg feed
Group C Diet without mycotoxins or additives
Group MR
Diet with 0.2% of MycoRaid (MR)
0.1 mg/ kg AFB1
3
0,2%
Group E-I
4 0,2% 0,2% 0,2%
E-II Diet with 0.1 mg AFB1/kg feed + 0.2%
Diet with 0.5 mg T-2 toxin/kg feed + 0.2% MR
E-VI Diet with 0.1 mg AFB1/kg feed and 0.5 mg T-2 + 0.2% MR 0.1 mg/ kg AFB1 0.1 mg/kg AFB1 0.1 mg/kg AFB1 0.5 mg/kg T 2 toxin 0.5 mg/kg T 2 toxin 0.5 mg/kg T 2 toxin 0.5 mg/kg T 2 toxin
Diet with 0.5 mg T-2 toxin/kg feed
Diet with 0.1 mg AFB1/kg feed and 0.5 mg T-2
Group
Group E-IV
Group
Group E-III
Group E-V
RESULTS
Results indicate that feed containing AFB1 and T‑2 toxin, alone or in combination, adversely affected poultry health and performance.
However, the addition of MR to diets containing AFB1 and T‑2 toxin, alone and in combination, exerted a positive effect on:
Body weight
Feed intake
Weight gain
Feed efficiency
Microscopic lesions in visceral organs
Additionally, residual concentrations of AFB1 in liver samples were significantly decreased (p < 0.05) when chicks were fed diets supplemented with 0.2% of MR.
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