HAROLD HAMM DIABETES CENTER ANNUAL REPORT
2014
HAROLD HAMM DIABETES CENTER
CONTENTS The mission of the Harold Hamm Diabetes Center is to be a world leader in eradicating diabetes through the advancement of innovative research focused on progress toward a cure, dramatically improved patient care, and diabetes prevention and education strategies.
9 RESEARCH FEATURES 17 PATIENT CARE FEATURES 25 PREVENTION AND OUTREACH FEATURES 32 HAROLD HAMM INTERNATIONAL PRIZE 34 LECTURES, CONFERENCES, & EVENTS 42 FINANCIAL INFORMATION 43 PHILANTHROPY 48 BOARD OF ADVISORS 49 MEMBERS 56 CENTER AND PROGRAM LEADERSHIP & STAFF 59 ACTIVE GRANTS 66 PUBLICATIONS 78 LOCATIONS
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Properly managing diabetes can save a person’s life. Sometimes, it can help create a life.
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hat’s what Harold Hamm Diabetes Center patient Mekenzi Love learned when she wanted to start a family. “Being diagnosed with diabetes when I was 8 years old, I found out early on that diabetes is a daily struggle—you have ups and downs. It is a dynamic disease and
it is unpredictable. It really makes life hard,” she explains. Those challenges were magnified when Mekenzi wanted to have her first child and start a family of her own. “Honestly, I always thought that having type 1 diabetes meant my chances of getting pregnant and successfully carrying a child were very slim. I lived my life thinking I would have to adopt.” That is, until she became a patient at Harold Hamm Diabetes Center. Mekenzi took advantage of the multidisciplinary team of healthcare providers including Christy Olson, MS, RD, LD, CDE, a dietician and Certified Diabetes Educator, and Albina Gosmanova, MD, an endocrinologist specializing in pregnancy. By implementing more stringent blood glucose monitoring therapies, including wearing an insulin pump, and stronger diabetes self-management techniques, Mekenzi ultimately lost 115 pounds, allowing her to successfully deliver a happy, healthy baby boy. Mekenzi and her son are proof of the hope given to the people impacted by diabetes because of the research-based healthcare offered at Harold Hamm Diabetes Center.
HAROLD HAMM DIABETES CENTER
MAKENZI LOVE THOUGHT THAT HAVING TYPE 1 DIABETES MEANT HER CHANCES OF GETTING PREGNANT WERE SMALL, IF NOT IMPOSSIBLE, AND THAT SHE WOULD HAVE TO ADOPT TO START A FAMILY. THAT IS, UNTIL SHE BECAME A PATIENT AT HAROLD HAMM DIABETES CENTER. SHE NOW HAS A HAPPY, HEALTHY SON THANKS TO THE HELP OF HER MULTIDISCIPLINARY TEAM OF HEALTHCARE PROVIDERS AT HAROLD HAMM.
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THE IMPACT OF DIABETES 29.1 MILLION
have diabetes in the US
1 OUT OF 4 do not know they have diabetes
1 3 OUT OF
RISK OF DEATH for adults with diabetes is 50% higher than for adults without diabetes
will develop diabetes in their lifetime
HAROLD HAMM DIABETES CENTER
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Adult diabetes diagnoses are increasing at a faster rate in Oklahoma than in the U.S.
1 OUT OF 3 Oklahomans have type 2 diabetes or are prediabetic
OKLAHOMA RANKS 4TH HIGHEST in the nation for deaths caused by diabetes
Adapted from: A Snapshot of Diabetes in the United States, Centers for Disease Control and Prevention, 2014; Diabetes in Oklahoma, Oklahoma State Department of Health, Chronic Disease Division, July 2014.
2 OUT OF 3 Oklahomans are obese or overweight, and thus at severe risk for developing type 2 diabetes
The risk for developing type 2 diabetes can be cut in half by participating in certified healthy lifestyle programs like those offered at Harold Hamm Diabetes Center
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OU MEDICINE IS, AT ITS HEART, KEEPING US ALIVE AND WELL. At Harold Hamm Diabetes Center, an OU Medicine comprehensive center of excellence, we have taken a strong lead in the field of diabetes, building an internationally recognized center that is synonymous with pioneering diabetes research, patient care, and prevention. When the center was established by an act of the state legislature in 2006, we knew that with the staggering growth in the occurrence of diabetes, we could no longer ignore the severe toll diabetes was taking on so many lives. The U.S. Centers for Disease Control and Prevention estimates that one in three children born in the United States today will go on to develop type 2 diabetes in their lifetime. It is even more severe in Oklahoma, which ranks fourth in the nation in diabetes mortalities. Even though diabetes affects so many, there were very few centers of excellence in the United States or the world addressing diabetes in a comprehensive manner by integrating research, patient care, and prevention, which is critical to addressing the disease in a meaningful way. Indicative of the Oklahoma pioneering spirit, we saw an opportunity. The state legislature and our Native American tribes joined the University and made significant commitments to establish a comprehensive diabetes center to serve as a catalyst for eradicating the diabetes epidemic. Their leadership and tenacity was contagious, leading many private donors to join the cause, most notably Harold Hamm who provided the lead gift for the center. The results of those efforts have had a tremendous impact. The center’s research group is one of the top-funded and largest in the world. The advances in our laboratories are being translated into dramatically improved patient care for those suffering from diabetes and its complications. Prevention programs focusing on healthy lifestyles are stopping diabetes before it starts. These accomplishments lead me to believe that the establishment of the center will be remembered by history as perhaps one of the greatest medical milestones. As you read through this report, you too will see the impact of the innovative energy radiating out from the center, inspiring hope that we will one day live free of diabetes.
David L. Boren President The University of Oklahoma
HAROLD HAMM DIABETES CENTER
At Harold Hamm Diabetes Center, we don’t see the growing numbers of people affected by diabetes as a threat. Instead, we see it as an opportunity to change lives for the better. It is true that diabetes has been called the most pressing threat to this generation’s health. If current trends continue, one in three adults in the United States will have type 2 diabetes by the year 2050. Today, that statistic is already becoming a reality in Oklahoma, where one in three Oklahomans either has type 2 diabetes or is prediabetic. Yet, we are not powerless against diabetes. There is much we have done, and still can do, to reduce the impact of diabetes to people not only in Oklahoma, but around the world. This inspires and encourages us to continue the rapid forward momentum of the Harold Hamm Diabetes Center into an international center leading the way to prevent, treat, and ultimately find a cure for diabetes. The pages of this report show how Harold Hamm Diabetes Center’s integration of research, patient care, and diabetes prevention and education programs are addressing diabetes from every angle to reduce its devastating impact on our society. The vision and efforts of so many have driven the unprecedented and life-changing developments and achievements spread throughout this report. Like you, we’re proud of these advancements, but we know they are only the beginning. This report also shows that we’re not fighting the diabetes epidemic alone. Indeed, we join many individuals, institutions, and organizations that are working together through a common purpose to lead us ever closer to living in a world without diabetes. For that reason, the most important sentiment we can express is our appreciation for you joining us in this shared mission. We look forward to the many successes that will result from our continued partnership.
Blake T. Rambo, JD, MBA Chief Operating Officer Harold Hamm Diabetes Center at the University of Oklahoma
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RESEARCH
RESEARCH
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EFFORTS TO PREVENT DIABETES CAN START EVEN BEFORE A PERSON IS BORN. DAVID
FIELDS, PHD, IS
INVESTIGATING HOW A MOTHER’S BREAST MILK COMPOSITION CAN PREVENT A DIAGNOSES OF TYPE 2 DIABETES LATER IN THEIR CHILD’S LIFE.
Watch Dr. Fields demonstrate the specialized equipment used to measure a child’s body fat composition
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RESEARCH
As a result of just $20,000 in seed money, a Harold Hamm Diabetes Center researcher received a $3.5 million National Institutes of Health grant to investigate the impact of breast milk on infant growth and the risk for diabetes later in life.
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avid Fields, PhD, CMRI Chickasaw Nation Chair in Pediatric Diabetes and associate professor of pediatrics, received the Linda Johnson Seed Grant from Harold Hamm Diabetes Center in 2011, allowing him to explore his hypothesis and develop the initial data to compete for national grant funding for his work.
With the help of that seed money, he received a $3.5 million grant from the National Institutes of Health to investigate the relationship between the nutritional composition of breast milk and a child’s risk for developing obesity and diabetes later in life. Fields is one of only a few researchers in the United States using specialized equipment to measure an infant’s body mass, allowing him to correlate a child’s body composition with the nutritional value of breast milk. “This grant is significant because it gives us a chance to develop intervention strategies that will help nursing mothers protect their children from being predisposed to type 2 diabetes,” said Fields. “We want to help mothers attain a health status that will produce the ideal levels of fat, carbohydrates, and protein—among other things—in the milk she provides her child that will help that child avoid obesity or type 2 diabetes.” Fields will collect samples from over 350 nursing mothers and will monitor the metabolism of their children by measuring the child’s ratio of fat-to-muscle mass over the first year of his or her life. The results of his study will be used to design intervention strategies aimed at reducing maternal weight during pregnancy and lactation, as well as improve lactation education materials currently available. Ultimately, his work will provide critical information to help support women and infants during prenatal development and to prevent obesity, diabetes and other health problems.
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Oklahoma leads the nation in the number of preventable amputations caused by complications from diabetes. Harold Hamm Diabetes Center has initiated work to change that.
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iersten Weber, DPM, podiatrist at Harold Hamm Diabetes Center, has initiated a study to analyze the lower extremity amputation rates and trends in Oklahoma. After examining both inpatient and outpatient data at non-federally funded hospitals in all of Oklahoma’s 77 counties, a list of the counties with the highest to
lowest lower extremity amputation rates was determined. Work has now begun to examine those counties with the highest levels to explore the potential impact of early intervention strategies to reduce those rates. “With the results of the study, I plan on looking more closely at the counties with the highest amputation rate to determine where we could intervene and implement a limb salvage and foot care program,” says Weber. “The program could be taught to healthcare staff and patients alike. The rate would then be re-analyzed after implementation of the program. The hope and goal would be to see a decrease in the rate of lower extremity amputations in these counties as a result of the intervention program.” In the United States, diabetes is the leading cause of lower extremity amputation among adults. In a state where the majority of the population is either diabetic or pre-diabetic, this study is critical in order to investigate what can be done to reduce amputations among Oklahomans.
RESEARCH
AMPUTATIONS ARE COMMON WITH DIABETES, BUT THEY DON’T HAVE TO BE. KIERSTEN
WEBER, DPM,
PODIATRIST AT HAROLD HAMM DIABETES CENTER, IS STUDYING WAYS TO IMPLEMENT INTERVENTION
Watch Dr. Weber talk more about how to care for your feet and decrease your risk for diabetic complications.
STRATEGIES AIMED AT REDUCING THE FREQUENCY OF AMPUTATIONS.
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Watch a TV news story about the MOVE study.
WITH THE GROWTH OF TYPE 2 DIABETES IN YOUTH, CAN GIVING A CHILD MONEY FOR EXERCISE AND HEALTHY
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LIFESTYLE HABITS, MUCH LIKE AN ALLOWANCE TO DO THEIR CHORES, PREVENT DIABETES? KEVIN
SHORT, PHD,
IS ASKING THAT QUESTION THROUGH HIS NIH-FUNDED “MOVE” RESEARCH STUDY.
RESEARCH
As a result of the climbing rates of diabetes diagnoses, it is now estimated that one in three children will develop type 2 diabetes during their lifetime.
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esearchers at Harold Hamm Diabetes Center are looking at new ways to curtail this trend through a study that explores how incentivizing exercise among young people could lead to healthier lifestyles and decreased risk of developing diabetes. “We are in unfamiliar territory in terms of type 2 diabetes prevention in youth,
because this condition, which used to be primarily associated with adults, is now becoming more prevalent in children,” said Kenneth Copeland, MD, Paul and Ann Milburn Endowed Chair in Pediatric Diabetes, professor of pediatrics, and director of Harold Hamm Diabetes CenterChildren’s. “Through Harold Hamm Diabetes Center’s leadership in a national study, we had already developed new protocols for treating diabetes in children, but nothing in terms of teaching those at risk how to avoid the disease.” When Copeland and Kevin Short, PhD, CMRI Choctaw Nation Chair in Pediatric Diabetes and associate professor in pediatrics, came together to discuss ways to stop the steady growth of diabetes in youth, they wondered if money, much like the allowance a child receives to do their chores, would shape behaviors to improve health outcomes and prevent diabetes. That’s how the research study, “MOVE,” now funded by the National Institutes of Health, was born. The study is part of a larger diabetes prevention effort led by Neil Henderson, Ph.D., professor in the College of Public Health and director of the American Indian Diabetes Prevention Center. The year-long MOVE study enrolls participants in three sessions, rewarding them with gift cards based on their number of visits to a workout facility, time spent exercising, and permanent behavior changes. MOVE, however, isn’t just about the money. The study is designed to encourage positive outcomes by improving physical fitness, lowering blood pressure, and helping teenagers learn permanent habits for better health.
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PATIENT CARE
PATIENT CARE
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Everyone is familiar with the saying that the first step is the hardest part. For people with diabetes, taking the first step to better control their disease can often be difficult, and many don’t know where to start.
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o help, Harold Hamm Diabetes Center began offering a free seminar, called Type 2 Step 1 in 2014. Whether someone is newly diagnosed or has had diabetes for years, the seminar introduces the comprehensive care services offered at Harold Hamm Diabetes Center.
The benefits of each service are covered in depth, focusing on the role they play in effectively managing diabetes to avoid complications. Patients are told what they can expect about the care they will receive, how to make their first appointment, and ways to take advantage of the maximum amount of their insurance benefits. Perhaps most importantly, participants in Type 2 Step 1 have an opportunity to meet their healthcare providers for the first time not in an exam room, but in a more relaxed and conversational environment, where they and their loved ones are free to ask questions and interact more casually with the center’s providers. As a result of this seminar, taking the first step has become much easier, helping put people on the path to living well with diabetes.
PATIENT CARE
WHETHER SOMEONE HAS BEEN NEWLY DIAGNOSED WITH DIABETES, OR HAS HAD IT FOR YEARS, HAROLD HAMM DIABETES CENTER’S NEW FREE SEMINAR, TYPE
2 STEP 1, INTRODUCES THE COMPREHENSIVE CARE
SERVICES OFFERED THROUGH THE CENTER AND HELPS PEOPLE TAKE THE FIRST STEP IN BETTER CARING FOR THEIR DIABETES.
Find out when the next Type 2 Step 1 session will be held
haroldhamm.org/annualreport
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Most people think of healthcare throughout their life in two phases: care from a pediatrician when you’re a child, and then care as an adult for the rest of your life.
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ut what about healthcare during the formative teenage years, when you’re not a child anymore but not quite yet an adult? To address the needs of the teenage population, Harold Hamm Diabetes Center established Wavelengths, a young adult program that helps ease the transition
from pediatric to adult care. It can be a challenging transition as young adults begin to assume more responsibility for their own diabetes care as they mature. Studies have shown diabetic adolescents transitioning into early adulthood commonly have a gap in care between pediatric and adult care, which results in poor diabetes management and increased risk for complications later in life. The Wavelengths program at Harold Hamm Diabetes Center helps prevent this. Wavelengths is led by James Lane, MD, Harold Hamm Chair in Clinical Diabetes Research, professor of medicine, and director of Adult Clinical Programs at Harold Hamm Diabetes Center; Joni Beck, BC-ADM, PharmD, CDE, associate professor of pediatrics and clinical program director at Harold Hamm Diabetes Center-Children’s, and Cynthia Muhamedagic, Ph.D., clinical psychologist and clinical assistant professor of pediatrics. “Not only do we hope to gain insight into why glucose control worsens, we hope to improve control and address questions related to what interventions are necessary,” Lane said. Data is collected regarding patient demographics, lab results, and attitudes from surveys. The patients are followed over time in order to study their progress as they transition into adulthood. The data collected in this study allows researchers and providers valuable insight into what could lead to better diabetes self-management in young patients. “This study provides a service for those who need it and helps further medical research, effectively impacting millions of people around the world suffering from diabetes,” said Lane. “This is why research activities like this transition program are important to the health needs of our society.”
PATIENT CARE
WITH HEALTHCARE TRADITIONALLY CENTERING ON EITHER PEDIATRIC OR ADULT POPULATIONS, THE UNIQUE NEEDS OF A TEENAGER DURING THEIR
Watch Dr. Joni Beck explain more about how the Wavelengths program works.
FORMATIVE YEARS ARE OFTEN OVERLOOKED. FOR THOSE WITH DIABETES, THIS CAN BE ESPECIALLY PROBLEMATIC. THE NEWLY ESTABLISHED HAROLD HAMM DIABETES CENTER WAVELENGTHS YOUNG ADULT TRANSITION PROGRAM PROVIDES THE UNIQUE CARE TEENAGERS WITH DIABETES NEED.
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AS PART OF THE COMPREHENSIVE CLINICAL SERVICES OFFERINGS AT HAROLD HAMM DIABETES CENTER, DIANNE
BROWN, MS, RD/LD, CDE,
TALKS ABOUT HEALTHY EATING, A CRITICAL COMPONENT OF PROPERLY MANAGING GESTATIONAL DIABETES, WHICH AFFECTS ONE IN EVERY FIVE PREGNANCIES.
Learn more about our gestational diabetes education services.
haroldhamm.org/annualreport
PATIENT CARE
Gestational diabetes affects one in every five pregnancies and can potentially create serious health problems for the mother and child, both during pregnancy and later in life.
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s part of its comprehensive clinical care services, Harold Hamm Diabetes Center offers gestational diabetes education to help ensure healthy and successful pregnancies. Gestational diabetes is a type of diabetes that only occurs during pregnancy. It
is triggered by pregnancy hormone changes, causing a mother’s blood glucose to be higher than normal. Pregnant women with no history or not at risk for gestational diabetes are tested early in the third trimester of pregnancy for gestational diabetes. If there is a risk or history, then they are tested for gestational diabetes at their first doctor’s visit. The risks associated with uncontrolled gestational diabetes affect both mother and child. The risks for infants born to mothers with gestational diabetes include: larger than normal babies, which many times results in an early birth via caesarian section, breathing problems, low blood sugar and obesity, which can lead to type 2 diabetes later in life, and even loss of the pregnancy. Through the center’s gestational diabetes program, expecting mothers who do develop this condition are provided with the support and education they need to manage it and better care for themselves and their child. Registered dieticians and Certified Diabetes Educators at Harold Hamm Diabetes Center assist pregnant women in keeping their diabetes under control by eating the right amount and type of foods, gaining the right amount of weight, exercising, and checking their blood glucose.
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PREVENTION AND OUTREACH
PREVENTION AND OUTREACH HAROLD HAMM DIABETES CENTER
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HAROLD HAMM DIABETES CENTER’S DIABETES
PREVENTION TOUR
OFFERED PROVIDERS AROUND THE STATE WHO SEE PATIENTS WITH DIBAETES WITH TOOLS TO BETTER TREAT AND MANAGE THE DISEASE.
Get details on 2014’s Diabetes Prevention Tour, including the sites that hosted the event
haroldhamm.org/annualreport
PREVENTION AND OUTREACH
The cure we have today for many at risk for diabetes is preventing it before it develops. That’s why Harold Hamm Diabetes Center leads the fight against diabetes not just in research laboratories and clinics but also through a variety of diabetes prevention programs.
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hanks to a partnership and grant from the Oklahoma State Department of Health, Harold Hamm Diabetes Center healthcare professionals developed the Diabetes Prevention Tour to travel around the state and offer healthcare providers the most up-to-date information to targeted healthcare providers with the intent
to enhance knowledge, skills, and practice. The Diabetes Prevention Tour provided a unique, all-day educational event for healthcare providers, addressing proven diabetes prevention, management, and treatment techniques. It promoted excellence in the prevention, management, and treatment of diabetes, including self-management. Topics covered included the prevention of diabetes within the Native American population, the relationship between hypertension and diabetes, motivational interviewing and behavior changes strategies, implementation of a diabetes prevention program model, and information regarding the National Quality Forum standards. “By reaching out to cities and towns across the state, we are impacting more than just those who walk through the doors of our buildings,” said Molly Fernando, Psy.D., clinical psychologist at Harold Hamm Diabetes Center and coordinator of the Diabetes Prevention Tour. “We are able to make an impact on providers who see numerous diabetes patients on a daily basis, and provide them with the tools to better treat these patients.”
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Two out of three Oklahomans are either obese or overweight, putting them at severe risk for developing type 2 diabetes.
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ecause diabetes is a problem of high magnitude, Harold Hamm Diabetes Center began offering, for the first time this year, certified training for people who are not healthcare professionals but are in a position to influence another person’s health, like workplace wellness coordinators and teachers.
Lifestyle Coaches, as they are called, educate and empower individuals to adopt healthy lifestyles habits proven to prevent diabetes. They help people develop and maintain the skills needed to eat right and exercise more. They provide education information, teach strategies for success, and work to address any challenges or barriers that may arise. The strategies that Lifestyle Coaches learn are based on the National Diabetes Prevention Program, a curriculum developed by the U.S. Centers for Disease Control and Prevention. As part of this curriculum, Lifestyle Coaches have a goal for those they help. They work to reduce body mass by at least 7 percent, which has been proven to more than cut in half a person’s risk for developing type 2 diabetes. Lifestyle Coaches trained by Harold Hamm Diabetes Center are making a significant impact beyond the walls of the center and playing a critical role in the community of preventing diabetes.
PREVENTION AND OUTREACH
TRAINING WAS OFFERED FOR THE FIRST TIME THIS YEAR FOR CERTIFIED
LIFESTYLE COACHES, WHO ARE
Watch Dr. Molly Fernando talk more about proven strategies for implementing healthy lifestyle changes
NON-HEALTHCARE PROFESSIONALS, LIKE WORKPLACE WELLNESS COORDINATORS OR TEACHERS, WHO EDUCATE AND EMPOWER INDIVIDUALS TO ADOPT HEALTHY LIFESTYLE HABITS PROVEN TO PREVENT DIABETES.
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HAROLD HAMM DIABETES CENTER’S NEW FREE SEMINAR
TYPE 2 OPTIONS HELPS REDUCE THE OFTEN DEBILITATING FINANCIAL BURDEN OF PROPERLY MANAGING DIABETES BY CONNECTING PEOPLE WITH COMMUNITY RESOURCES THAT CAN HELP AND BY PROVIDING MUCH NEEDED EDUCATION ABOUT HOW TO EFFECTIVELY MANAGE DIABETES AND PREVENT COMPLICATIONS.
Find out when the next Type 2 Options seminar will be held
haroldhamm.org/annualreport
PREVENTION AND OUTREACH
Average medical costs for individuals with diabetes are more than double than those without the disease.
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or many, properly managing their diabetes to reduce more costly and life-threatening complications later creates a significant financial hardship. To help reduce this burden, Harold Hamm Diabetes Center staff developed Type 2 Options, a free, two-hour seminar for adults with type 2 diabetes to connect
them with community resources that can help them lead healthier lives. Offered for the first time in 2014, Type 2 Options provides valuable guidance about community resources for people with diabetes to assist with needed medications and diabetic testing supplies such as test strips and blood glucose meters. In addition, free educational services are provided by Harold Hamm Diabetes Center Certified Diabetes Educators. Topics include maintaining safe blood glucose levels, making healthy food choices at home or on-the-go, and integrating diabetes-safe exercise into your daily routine. They also discuss preventing diabetes-related complications, coping with stress and emotional challenges of diabetes. Many of the program's participants are either underinsured or have no insurance at all. Often, those people have no choice but to go without healthcare. Thanks to this program, however, they have a partner in Harold Hamm Diabetes Center to receive the help they need.
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HAROLD HAMM INTERNATIONAL PRIZE FOR BIOMEDICAL RESEARCH IN DIABETES
Read more about the Hamm Prize
HAROLD HAMM DIABETES CENTER
“MY HOPE IS THAT THIS RESEARCH PRIZE WILL LIGHT A WORLDWIDE FIRE OF SCIENTIFIC INNOVATION TOWARD FINDING A CURE FOR DIABETES WITHIN THIS GENERATION.” — HAROLD HAMM
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$250,000 award, the Hamm Prize recognizes and promotes innovative research focused on progress toward a cure for diabetes. The Hamm Prize Laureate is selected by a jury of five internationally recognized leaders in the field of diabetes. The 2015 selection jury includes:
•E leuterio Ferrannini, MD, PhD, Professor of Internal Medicine at the University of Pisa School of Medicine and Chief of the Metabolism Unit at the National Research Council Institute of Clinical Physiology •G eorgeanna Klingensmith, MD, Chief of Pediatric Clinics at the Barbara Davis Center for Diabetes and Professor of Pediatrics at the University of Colorado School of Medicine •R obert Rizza, MD, Professor of Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition at the Mayo Clinic •E lizabeth Seaquist, MD, Pennock Family Chair in Diabetes Research, Professor of Medicine at the University of Minnesota Medical School •G ordon Weir, MD, Senior Investigator, Diabetes Research and Wellness Chair at Joslin Diabetes Center and Professor of Medicine at Harvard Medical School “My hope is that this research prize will light a worldwide fire of scientific innovation toward finding a cure for diabetes within this generation,” said Harold Hamm, whose gift provided for an endowment to ensure the prize’s continuation in perpetuity. “This Prize will encourage researchers to look more intensely at research focused on progress toward a cure, and give them the ability to develop new approaches to fighting this disease.” The Hamm Prize will be officially presented to the Laureate at the Connect+Cure Gala benefitting Harold Hamm Diabetes Center on October 26, 2015, in Oklahoma City, Oklahoma.
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2014 RESEARCH SYMPOSIUM KEYNOTE ADDRESS Insulin, Osteoblasts and Energy Metabolism: Why Bone Counts Calories THOMAS L. CLEMENS, PHD Lewis Cass Spencer Professor of Orthopedic Surgery Department of Orthopedic Surgery Johns Hopkins University
The annual Harold Hamm Diabetes Center Research Symposium is a hallmark event bringing together researchers from across diverse disciplines to present the latest findings in their areas as they relate to diabetes. It creates a unique forum for scientists in diabetes basic science, translational research, and clinical research to present their data and receive immediate responses from their peers, creating an environment of ongoing dialogue and collaboration.
ORAL PRESENTATIONS FIRST PLACE
SECOND PLACE
THIRD PLACE
Qian Chen
Lee Bockus
David Deschamps
Differential Roles of Very
Dysfunctional cAMP-
Only the fasting glucose
Low-Density Lipoprotein
Dependent Protein Kinase
value predicts neonatal body
Receptorsplice Variants in
(PKA) signaling causes
composition in a multi-center
Regulating WNT Signaling
impaired Autonomic control
cohort undergoing testing for
in Diabetic Heart Failure
Gestational Diabetes
Yusuke Takahashi
Co-contributor:
Co-contributors:
Kyungwon Lee
Kenneth Humphries
Ravindu Gunatilake
Co-Contributors:
Kazuhiro Oka
Marvin Williams
Jian-Xing Ma
Dean Myers Patrick Catalano David Fields
CONFERENCES, LECTURES, AND EVENTS
POSTER PRESENTATIONS FIRST PLACE
THIRD PLACE
Mei Du
Jami Gurley
Investigating the Molecular Mechanisms of
Insulin-Sensitive GLUT4-Transgenic mice have
RBP4-Induced Endothelial Inflammation and
decreased skeletal muscle mitochondrial protein
Retinal Degeneration
Co-Contributors:
Co-contributors:
Beth Griesel
Laura Otalora
Ann L. Olson
Alexander Yeganeh Ashley Martin Gennadiy Moiseyev Krysten M. Farjo SECOND PLACE
Elizabeth Moran Protective and Antioxidant Effects of PPARAlpha in Diabetic and Ischemic Retinopathies Co-contributors: Lexi Ding Rui Cheng Qian Chen Zhongxiao Wang Yusuke Takahashi Jian-xing Ma SECOND PLACE
Rui Cheng PPAR-Alpha Inhibits the Canonic WNT Pathway through Regulating NOX4/ROS in Diabetic Nephropathy Co-Contributors: Lexi Ding Xuemin He Jian-xing Ma
THIRD PLACE
Bishwa Sapkota Genetic Association of APOE Polymorphisms in response to anti-hyperglycemic medications Co-Contributors: Anuradha Subramanian Hadley Finely Piers Blackett Dharambir Sanghera THIRD PLACE
Robert Jackson Caloric Reduction induces weight loss and insulin sensitization in high-fat fed mice Co-Contributor: Ann L. Olson
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2014 RESEARCH SYMPOSIUM (continued)
ORAL PRESENTATIONS Adipokines in umbilical cord serum from
Regulatory role of MicroRNA-184 in Diabetic
Diabetic and healthy pregnancies
Retinopathy
April Teague
Yusuke Takahashi
Gestational Diabetes is associated with
Western diet decreased and delayed placenta
alterations in maternal fatty acid binding
growth factor upregulation in femoral artery
protein 4, Lipids, and Lipoprotein measures
ligated mice
Christina Scifres
Asitha Silva
Glycemic Variability is associated with Oxidative
Differential expression of micro-RNAs among
stress in children with Type 2 Diabetes
normal weight, obese and Type 2
compared to non-diabetic peers
diabetic children
Benjamin S. Gandomani
Jeanie Tryggestad
The novel role of toll-like receptor 4 in the
Obesity in aging exacerbates neuroinflammation,
development of insulin resistance
synaptic plasticity deficit and cognitive decline in
Ellen Jackson
mice
Role of Autophagy in Diabetic impairment of Angiogenesis Jian Xu
Zsuzsanna Tucsek
CONFERENCES, LECTURES, AND EVENTS
POSTER PRESENTATIONS Continuous glucose monitoring in low physical
The effect of mango supplementation on clinical
activity youth with and without Type 2
parameters of pre-diabetic individuals
Diabetes
Jessica Semkoff
Paul Dasari
Improved glucose tolerance in adolescents after a
Presence of Metabolic Syndrome and its
single session of handcycle exercise
relation to bone mineral density in a small
Kevin Short
cohort of XYDSD patients Paul Dasari Performance of the fasting glucose value alone for diagnosing gestational diabetes and predicting neonatal adiposity David Deschamps Low-density lipoprotein receptor-related protein 5 drives renal fibrosis via the TGF-B1 signaling pathway Xuemin He An evaluation of the barriers to patient use of glucometer control solution: surveys of patients, pharmacists, and prescribers Jeremy Johnson Mechanisms of cone maintenance in diabetic retinopathy Yun-Zheng Le Diabetes alters the regulation of insulin sensitive glucose transporters in the atria Zahra Maria Selective inactivation of deactivation mitochondrial complex I by biguanides Satoshi Matsuzaki
Incentivizing physical activity in American Indian youth Kevin Short Metabolic derangements in gestational diabetes mellitus offspring: role for breast milk Katy Duncan Smith Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: prevention by the metabolic regulator resveratrol Stefano Tarantini The use of data from large cohort studies in the design of prevention programs: strong heart study Wenyu Wang Functional impact of β, β-Carotene -9’, 10’-Oxygenase 2 in hepatic mitochondria Lei Wu Incidence and risk factors for end stage renal disease among American Indians: the strong heart study Ying Zhang Efficient induction of productive Cre-Mediated recombination in the retinal pigment epithelim Meili Zhu
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CONFERENCES Diabetes Update Hosted by Harold Hamm Diabetes Center annually each fall, Diabetes Update shares the latest advances in research and treatment coming out of Harold Hamm Diabetes Center and other institutions. Beyond the Basics Beyond the Basics, hosted by Harold Hamm Diabetes Center each spring, brings together nurses, dietitians, pharmacists, and other health professionals to discuss and demonstrate current treatment strategies for the effective management of diabetes.
CONFERENCES, LECTURES, AND EVENTS
Diabetes Update 2014
Beyond the Basics 2014
Continuous Glucose Monitoring: From
Keynote: Diabetes and Chronic Kidney Disease
Prescription to Practice
Andrew Narva, MD, FACP, FASN, Director,
Rebecca Allen, MS, RD, LD, CDE, and
National Kidney Disease Education Program,
Christy Olson, MS, RD, LD, CDE
National Institutes of Health
Improve the Management of the Severely
Social Media’s Role in Diabetes Self-Management
Insulin Resistant Patient using U-500 Insulin
Manny Hernandez, MS
Madona Azar, MD
Type 1 versus Type 2 Diabetes: How to Avoid the Pitfalls of Misdiagnosing Kenneth Copeland, MD
Is Breast Feeding Best? David Fields, PhD
Care of Cystic Fibrosis Patients: Endocrinology Role Kim Hummer, MD
Diet Counseling for People with Diabetes and Kidney Disease Theresa Ann Kuracina, MS, RD, CDE, LN
Cultural Competence in the Diabetes Education
Guidelines for Atherosclerotic Cardiovascular
Setting: Beyond Race and Ethnicity
Disease Risk Reduction in the Diabetes
Michelle M. Lamb, PharmD, CDE, BC-ACP
Population Weston Hickey, MD
Care of the Patient with Chronic Kidney Disease from Diabetes Satish Kumar, MD
Updated Guidelines and Therapies for the Treatment of Type 2 Diabetes James Lane, MD
Care of the Patient with Diabetes in the Nursing Home Bich-Thy Ngo, MD
Clinical Applications of Insulin Pump Therapy and Continuous Glucose Monitoring Shari Stevens, RN, BSN, CDE
Solving Strategies for Insulin Delivery Sally Westfall, MS, RN, CDE
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VISITING LECTURESHIPS AND PROFESSORSHIPS HAROLD HAMM DIABETES CENTER LECTURE SERIES The Harold Hamm Diabetes Center Lecture Series is hosted twice per year to promote an interdisciplinary community of learning and practice in diabetes through a focus on broad and universally applicable topics in the field of diabetes research, clinical care, and prevention.
The Challenges of Diabetes in the 21st Century Richard Hellman, MD, FACP, FACE Clinical Professor of Medicine, University of Missouri-Kansas City School of Medicine Past President, American Association of Clinical Endocrinologists Vice Chair, Physician Consortium for Performance Improvement Medical Director, Heart of America Diabetes Research Foundation
How and Why the Brain Fails Us in Obesity and Diabetes Christoph Buettner, MD, PhD Associate Professor Medicine, Endocrinology, Diabetes and Bone Disease Mount Sinai Icahn School of Medicine
KELLY WEST LECTURESHIP Department of Medicine, Section of Diabetes and Endocrinology
In honor of Kelly West, known as the “father of diabetes epidemiology,� this lectureship hosts world-renowned experts in diabetes research.
The Changing Character of the Diabetes Epidemic and What It Means for the U.S. and for Oklahoma Edward Gregg, PhD Chief, Epidemiology and Statistics, Division of Diabetes Translation National Center Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention
CONFERENCES, LECTURES, AND EVENTS
HENRY TURNER LECTURE Department of Medicine, Section of Diabetes and Endocrinology
Henry Turner established one of the first radioisotope laboratories in Oklahoma and is known for correctly identifying the phenotypic symptoms of what is now known as the Turner-Ullrich Syndrome
Advances in the Management of Medullary Thyroid Carcinoma: The Rapid Development of Multikinase Inhibitors Targeting RET, VEFR2, and Other Kinases Robert F. Gagel, MD Professor of Medicine and Head, Division of Internal Medicine University of Texas M.D. Anderson Cancer Center
CMRI JACK & EVELYN TRACHTENBERG VISITING PROFESSOR Department of Pediatrics, Section of Diabetes and Endocrinology
Established in 2004 by the generosity of the Larry and Mary Trachtenberg family and by Children’s Hospital Foundation, the Jack and Evelyn Trachtenberg childhood diabetes endowment provides the resources to enhance diabetes research and teaching in the state of Oklahoma by inviting national leaders in the field of diabetes research to speak on the campus of the University of Oklahoma Health Sciences Center.
How Growing Up Sweet Can Turn Sour: Sugars, Obesity and Metabolic Risk During Growth Michael Goran, PhD University of Texas San Antonio
CMRI MACY NIGH WHITENER VISITING PROFESSORSHIP Named for the granddaughter of former Oklahoma governor and first lady George and Donna Nigh, this lecture was established through an endowment from the Children’s Hospital Foundation to bring progressive research and education about diabetes to the state of Oklahoma each year.
The Changing Spectrum of Childhood Diabetes Mellitus Mark A. Sperling, MD, FRACP, MBBS Professor of Pediatrics Division of Pediatric Endocrinology, Diabetes, and Metabolism University of Pittsburgh School of Medicine Children’s Hospital of Pittsburgh of UPMC
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42 2014 ANNUAL REPORT
PARTNERS IN ERADICATING DIABETES Diabetes is a growing epidemic, but it’s not one we’re powerless against. Thanks to the generous support and commitment of the following donors in 2014, Harold Hamm Diabetes Center continues to advance the ideal that we will one day live in a world free from diabetes. ALLOCATION OF PHILANTHROPIC FUNDING as of June 30, 2014
51.3% Endowed Chairs and Professorships 32.8% Research 7.4% Clinical Care 2.3% Prevention and Outreach 0.4% Facilities 4.0% General Enrichment
PHILANTHROPIC FUND EXPENDITURES BY TYPE FISCAL YEAR 2014 July 1, 2013 to June 30, 2014
26% Research: Basic
7% Research: Pediatric Clinical
26% Patient Care: Adult
7% Patient Care: Pediatric
10% Prevention and Outreach 20% Facilities
3% General Enrichment
PHILANTHROPY
PARTNERS for PROGRESS
Governor Bill Anoatubby Ronald W. Atchley Blanchard Chapter Order of the Eastern Star Bogan, Dunlap & Wood Insurance Agency, LLC James Boggs Mike Borelli Mike Bostick Lori Neal Bowman Blake Brown
Italicized names on this list denote 2014 members of Partners for Progress, Harold Hamm Diabetes Center’s annual fund. Contributions from Partners for Progress are the foundation on which the center is built, touching every aspect of diabetes research, patient care, and prevention.
Glen Brown Linda Brown in honor of Judy Dixson and Ridge Smith Pete and Barbara Brown Jon Bryant Carol Burr Michael Burrage Leta Burwell Ken Carpenter Drew Chadwick Chandler Lions Club Becky Chandler Cherokee Lions Club Dakota Cole Lori Contanny Continental Resources, Inc. Jackie Cooper Somerlyn Cothran Harold Courson Joseph W. Craft Tom Cronin Greg Davis Joshua C. Davis Richard Dawson Jared DeShields Dobson Family Foundation Duncan, Fraser & Bridges Insurance Agency, Inc.
Holly Easterling Wade Edmundson Enid Typewriter Company John Ensey Barbara L. Eskridge Christy Estes Cheryl Evans Forsberg Engerman Co. Fred Daniel & Sons, Inc. Jill Gee Marlin ‘Ike’ Glass Jr. Chuck Greenwood Peter Gries Halliburton Energy Services Harold Hamm Harrah Lions Club Jana Harrison Andrea Horner Barbara Howard Howard Family Charitable Foundation, Inc. Insurica Jackfork Land Inc. JMA Energy Company, LLC Lisa John
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44 2014 ANNUAL REPORT
Jerry Jones Steven Jordan Kendra Scott Design, Inc.
DJH FOUNDATION PEDIATRIC CLINICAL TRIALS UNIT FOR DIABETES
Brent W. LaGere
A $350,000 gift from the DJH Foundation
Laird & Doolin Insurance
will establish the first and only clinical trials
Shelly Lambertz
unit for pediatric diabetes within Oklahoma.
Lawton Noon Lions Club, Inc.
The DJH Foundation was created in 2007
Hilda Lewis
by Muldrow residents Donald and Joyce
Bruce Magill
Harvey and aims to help prevent and control
Debbie Martin
cancer, asthma and diabetes in children. The
McAnally Wilkins
DJH Foundation Pediatric Clinical Trials Unit
Robert W. McGregor
for Diabetes will offer Oklahoma children
Robert Mills
the most advanced diabetes treatments and
Sarah Miracle
therapies currently available.
Melvin Moran G. Jeff Mowry Larry and Linda Neal Monica Neal Martha Ogilvie Dirk O’Hara Oklahoma Business Insurors Agency LLC Judy Goforth Parker
IN CARING MEMORY: LINDA JOHNSON
Noah Parris
In October of this year, we lost a friend and
Harry Phillips
generous supporter who left a lasting legacy
James Phillips
on the center. Linda Johnson provided a gift
Plaster & Wald Consulting Corp.
to support a $20,000 research seed grant
Leslie Rainbolt-Forbes
that allowed Dr. David Fields to do the initial
Blake T. Rambo
research required to obtain a $3.5 grant from
Records-Johnston Family Foundation Inc.
National Institutes of Health earlier this year.
Eddie W. Rhea
His work studies the impact of mothers’ health
Rich & Cartmill, Inc.
on children’s risk for obesity and diabetes.
Jonathan Rondon
Through this work and the many other
Michael Samis
projects she has supported, her legacy lives on.
Sanford & Tatum E. Tod Sanger Ed Schafer
PHILANTHROPY
OKLAHOMA LIONS CLUBS
John Schmitz
Lions Club International is the world’s largest
Sammie Smith
service club organization and one of its
William D. Sinclair in memory of Hulan and Zula Smith
priorities is diabetes awareness, education,
Daniel Somers
and prevention. The center and several key
Mike Somers
supporters began reaching out to the over
Adam Stafford
150 Lions Clubs in Oklahoma with diabetes
Mark Tedford
prevention information and asked that they
The Ben & Bonnie Walkingstick Foundation
support the work of Harold Hamm Diabetes
The Meinders Foundation
Center. Several clubs across the state have
Harolyne K. Thielke
responded to this request with generous
Arthur Thompson
contributions.
Todd Threlkeld Upshaw Insurance Marilyn Vandever Scott Verplank Sammie Villines Walden Cleaners & Laundry Inc. Dewey Wallace
THE MEINDERS FOUNDATION RESEARCH SEED GRANT A $1 million gift from The Meinders
Lisa Wallace Valorie Walters William Weppner in memory of Ben Van Allen
Foundation of Oklahoma City has established
Robert West
an endowment to provide a provide seed
Lonney H. White
awards for junior investigators to initiate
Tommy White
research projects and develop preliminary data
Nancy C. Wilson
to be most competitive for multi-million dollar
in memory of George William DeWolf
national grants. In recognition of this generous
Joseph Winkler
gift, the atrium of the diabetes center was
Skip and De Wood
named for Robert H. Meinders, a member of
Woods Insurance Service
the foundation’s board of directors.
WPX Energy
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46 2014 ANNUAL REPORT
FOUNDERS
Contributions of $1 million and more Cherokee Nation The Kelly West Society honors donors
The Chickasaw Nation
who have been a driving force behind
Children’s Hospital Foundation
the breakthroughs at Harold Hamm
Choctaw Nation of Oklahoma
Diabetes Center through substantial
Continental Resources, Inc.
gifts and commitments.
Harold Hamm
The society is named for Dr. Kelly M. West, an esteemed researcher at the University of Oklahoma who is widely regarded internationally as the “father
Hille Family Charitable Foundation The Meinders Foundation Paul H. and Doris Eaton Travis The University of Oklahoma
of diabetes epidemiology.” Dr. West’s
BENEFACTORS
passion to understand diabetes lives
Contributions of $500,000 to $999,999
on in the thoughtful and innovative research, patient care, and prevention programs at Harold Hamm Diabetes
The Anne and Henry Zarrow Foundation Mr. Henry Zarrow
Center supported by the generosity of
PATRONS
members of the Kelly West Society.
Contributions of $100,000 to $499,999 Paul E. and Britani Talley Bowman Chesapeake Energy Corporation DJH Foundation MidFirst Bank Presbyterian Health Foundation John Schmitz William K. Warren Foundation
PHILANTHROPY
PARTNERS
SUPPORTERS
Contributions of $50,000 to $99,999
Contributions of $20,000 to $49,999
Alliance Resource Partners, LP
Agio
BlueCross BlueShield of Oklahoma
The Anschutz Foundation
Cyclone Drilling, Inc.
BancFirst/Rainbolt Family
Devon Energy Corporation
Louise and Clay Bennett
E.L. and Thelma Gaylord Foundation
Jackie Cooper
JEH Investments
Mrs. Henry Freede
Linda Johnson
George Kaiser Family Foundation
Mary Gaylord McClean
Grand Chapter of Oklahoma, Order of the
Amy and Malone Mitchell 3rd
Eastern Star
Berry and Regina Mullennix
Gungoll, Jackson, Box & Devoll, P.C.
National American Insurance Company
Howard Family Charitable Foundation
Schlumberger Technology Corp.
Brent LaGere
Sigma Phi Epsilon Oklahoma Beta Chapter
Shelly Lambertz
WellPro, Inc.
Le Norman Operating LLC Mathis Brothers Furniture John and Darlene McNabb Herman and LaDonna Meinders Smiths Medical MD, Inc. Tenaris Estate of Nathanial Waters Whitten Burrage Law Firm
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48 2014 ANNUAL REPORT
BOARD OF ADVISORS
Governor Bill Anoatubby, Chair Regina Mullennix, Chair-Elect Harold Hamm, Immediate Past Chair
The Harold Hamm Diabetes Center Board
Mayor Dewey Bartlett
of Advisors recognizes that because of the
Louise Bennett
increasing prevalence of diabetes and the toll
James Boggs
it is taking on our health, there has never been
Barbara Brown
a greater need to support the mission of the
Jackie Cooper
Harold Hamm Diabetes Center.
Mayor Mick Cornett
The Board of Advisors is a group of volunteers dedicated to advancing key initiatives of the Harold Hamm Diabetes Center by employing their own personal talents, expertise, and resources. Board members serve as advocates in the community to increase awareness of the urgency of the diabetes health crisis and how the center is responding. They also play a key role in the development of financial resources to strengthen the center’s programs in diabetes research, patient care, and prevention.
Somerlyn Cothran Joe Craft Tom Cronin Rick Dawson Ike Glass Chuck Greenwood Mike Gundy Bob Howard Brent LaGere Shelly Lambertz Doug Lawler Jeff McDougall Herman Meinders Leona Mitchell Berry Mullennix Rick Muncrief Dirk O’Hara Chief Greg Pyle Leslie Rainbolt-Forbes, MD T.J. Riley Mike Samis John Schmitz Bob Stoops Kristin Thomas Michael Turpen Scott Verplank
MEMBERS
MEMBERS Martin-Paul Agbaga, PhD Dean McGee Eye Institute Assistant Professor of Research Departments of Ophthalmology and Cell Biology College of Medicine Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center Muayyad Al-Ubaidi, PhD Professor Vice Chair for Research Department of Cell Biology College of Medicine University of Oklahoma Health Sciences Center Robert Eugene Anderson, MD, PhD Director of Research, Dean McGee Eye Institute George Lynn Cross Research Professor Dean McGee Professor of Ophthalmology Departments of Ophthalmology and Cell Biology Adjunct Professor Department of Geriatric Medicine College of Medicine University of Oklahoma Health Sciences Center Madona Azar, MD Assistant Professor Assistant Director, Fellowship Program Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Jo Azzarello, PhD, RN Associate Professor College of Nursing University of Oklahoma Health Sciences Center Mary Zoe Baker, MD David Ross Boyd Professor Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Associate Chief of Staff for Education Oklahoma City VA Medical Center
Joni Beck, PharmD, BC-ADM, CDE Associate Professor and Clinical Programs Director Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center Piers Blackett, MD Clinical Professor Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center Laura Chalmers, MD Assistant Professor Department of Pediatrics School of Community Medicine OU-Tulsa Chi Bun Chan, PhD Assistant Professor Department of Physiology College of Medicine University of Oklahoma Health Sciences Center Steven Chernausek, MD CMRI Edith Kinney Gaylord Chair Professor Director, CMRI Pediatric Metabolic Research Program Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center Alex Cohen, MD, PhD Dean McGee Eye Institute W. Stanley Meunzler Endowed Professor of Corneal Disease Assistant Professor Co-Fellowship Director Department of Ophthalmology College of Medicine University of Oklahoma Health Sciences Center
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50 2014 ANNUAL REPORT
MEMBERS (continued)
Kenneth Copeland, MD Director, Harold Hamm Diabetes Center-Children’s Paul and Ann Milburn Endowed Chair in Pediatric Diabetes Edith Kinney Gaylord Presidential Professor Section Chief, Section of Diabetes and Endocrinology Vice Chairman, Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center Nicholas Davis, PhD Assistant Professor of Research Department of Medical Informatics School of Community Medicine OU-Tulsa Eduardo De Sousa, MD Associate Professor Division of Neuromuscular Disorders Department of Neurology College of Medicine University of Oklahoma Health Sciences Center Ferenc Deåk, MD, PhD Assistant Professor Reynolds Oklahoma Center on Aging Department of Geriatric Medicine Adjunct Professor Department of Physiology College of Medicine University of Oklahoma Health Sciences Center Carol Dionne, PT, DPT, PhD, OCS, Cert MDT Associate Professor Rehabilitation Sciences Director, Mechanical Therapy Research Lab Adjunct Associate Professor, Allied Health Sciences Co-Director, RS Post-Professional Programs College of Allied Health University of Oklahoma Health Sciences Center Michael Elliott, PhD Dean McGee Eye Institute Assistant Professor Department of Ophthalmology Adjunct Assistant Professor Department of Physiology College of Medicine Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center Blas Espinoza-Varas, PhD Associate Professor Department of Communication Sciences and Disorders College of Allied Health University of Oklahoma Health Sciences Center
Krysten Farjo, PhD Assistant Professor Department of Physiology College of Medicine University of Oklahoma Health Sciences Center Molly Fernando, PsyD Clinical Psychologist Behavioral Health Coordinator, Prevention and Outreach Programs Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center David Fields, PhD CMRI Chickasaw Nation Chair in Diabetes Research Associate Professor Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center Ashlee Ford Versypt, PhD Assistant Professor School of Chemical Engineering College of Engineering, Architecture, and Technology Oklahoma State University Stephen Fransen, MD Dean McGee Eye Institute Associate Professor Department of Ophthalmology College of Medicine University of Oklahoma Health Sciences Center Willard Freeman, PhD Reynolds Chair in Aging Research Associate Professor Department of Physiology Adjunct Associate Professor Department of Geriatric Medicine College of Medicine University of Oklahoma Health Sciences Center Andrew Gardner, PhD Donald W. Reynolds Chair in Aging Research Professor Department of Geriatric Medicine College of Medicine University of Oklahoma Health Sciences Center
MEMBERS
Minu George, MD Assistant Professor Medical Director, Pediatric Diabetes and Endocrinology Outpatient Clinics Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center Jay Hanas, PhD Professor Department of Biochemistry and Molecular Biology College of Medicine University of Oklahoma Health Sciences Center Franklin Hays, PhD Assistant Professor Department of Biochemistry and Molecular Biology College of Medicine Adjunct Assistant Professor Department of Nutritional Sciences College of Allied Health University of Oklahoma Health Sciences Center Kenneth Humphries, PhD Assistant Member Free Radical Biology and Aging Program Oklahoma Medical Research Foundation David Jelley, MD Director, Harold Hamm Diabetes Center-Tulsa Hille Chair in Diabetes Associate Professor Department of Pediatrics School of Community Medicine University of Oklahoma-Tulsa Venkataraman Kalyanaraman, MD Clinical Assistant Professor Section of Diabetes, Endocrinology and Metabolism Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Oklahoma City VA Medical Center Dimitrios Karamichos, BEng, MSc, PhD Dean McGee Eye Institute Assistant Professor Departments of Ophthalmology and Cell Biology College of Medicine Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center
Anne Kasus-Jacobi, PhD Assistant Professor of Research Department of Pharmaceutical Sciences College of Pharmacy University of Oklahoma Health Sciences Center David Kem, MD George Lynn Cross Research Professor Regents Professor Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Gopan Krishnan, PhD Assistant Professor Bioanalytical and Clinical Sensor Research Department of Chemistry College of Arts and Sciences Oklahoma State University Sowmya Krishnan, MD Assistant Professor Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center Biji Kurien, PhD Associate Professor of Research Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Veronique Lacombe, DVM, PhD Associate Professor Physiological Sciences Center for Veterinary Health Sciences Oklahoma State University Adjunct Associate Professor Department of Physiological Sciences University of Oklahoma Health Sciences Center James Lane, MD Director, Harold Hamm Diabetes Center-Adult Clinical Services Harold Hamm Chair in Clinical Diabetes Research Professor and Section Chief Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center
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MEMBERS (continued)
Yun Le, PhD Choctaw Nation Chair in Diabetes Research Associate Professor Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Jonea Lim, MD Assistant Professor Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Timothy Lyons, MD, FRCP Professor of Diabetes and Translational Medicine Director of the Diabetes Research Program Queen’s University of Belfast Professor of Research College of Medicine University of Oklahoma Health Sciences Center Jian-xing Ma, MD, PhD Director of Research, Harold Hamm Diabetes Center Laureate Professor and Chairman Department of Physiology College of Medicine University of Oklahoma Health Sciences Center Rafael Malgor, MD Assistant Professor Division of Vascular Surgery Department of Surgery College of Medicine-Tulsa OU-Tulsa Nawajes Mandal, PhD Dean McGee Eye Institute Assistant Professor Department of Ophthalmology Adjunct Assistant Professor Departments of Cell Biology and Physiology College of Medicine Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center Hiroyuki Matsumoto, PhD Professor Department of Biochemistry and Molecular Biology College of Medicine University of Oklahoma Health Sciences Center
Cynthia Muhamedagic, PhD Clinical Assistant Professor Department of Pediatrics College of Medicine Licensed Clinical Psychologist Behavioral Health Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center Dean Myers, PhD John W. Records Chair in Maternal Fetal Medicine Professor Section of Maternal Fetal Medicine Department of Obstetrics and Gynecology College of Medicine University of Oklahoma Health Sciences Center Tomoko Obara, PhD Assistant Professor of Cell Biology Department of Cell Biology College of Medicine University of Oklahoma Health Sciences Center Ann Olson, PhD Professor Biochemistry and Molecular Biology Adjunct Professor Department of Pediatrics College of Medicine Assistant Dean Graduate College University of Oklahoma Health Sciences Center Calin Prodan, MD Professor Department of Neurology College of Medicine University of Oklahoma Health Sciences Center Raju Rajala, PhD Dean McGee Eye Institute M.G. McCool Chair in Ophthalmology Professor Departments of Ophthalmology and Physiology Adjunct Professor Department of Cell Biology College of Medicine Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center Arlan Richardson, PhD Donald Reynolds Endowed Chair of Aging Research Professor Department of Geriatric Medicine College of Medicine University of Oklahoma Health Sciences Center
MEMBERS
Alicia Salvatore, DrPH, MPH Assistant Professor Department of Occupational and Environmental Health College of Public Health University of Oklahoma Health Sciences Center
Kelly Standifer, PhD Professor and Chair Department of Pharmaceutical Sciences College of Pharmacy University of Oklahoma Health Sciences Center
Dharambir Sanghera, BS, MS, PhD, FAHA Associate Professor Section of Genetics Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center
David Stanford, PhD Assistant Professor of Research Department of Physiology College of Medicine University of Oklahoma Health Sciences Center
Christina Scifres, MD Assistant Professor Section of Maternal Fetal Medicine Department of Obstetrics and Gynecology College of Medicine University of Oklahoma Health Sciences Center Robert “Hal� Scofield, MD Professor Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Member, Arthritis and Clinical Immunology Program Oklahoma Medical Research Foundation Staff, Medical Service, Oklahoma City VA Medical Center Vinay Shah, MD Dean McGee Eye Institute Clinical Associate Professor Department of Ophthalmology College of Medicine University of Oklahoma Health Sciences Center Kevin Short, PhD CMRI Choctaw Nation Chair in Pediatric Endocrinology Associate Professor Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center Susan Sisson, PhD, RDN, CHES, FACSM Assistant Professor Director, Behavioral Nutrition and Physical Activity Laboratory Department of Nutrition Sciences College of Allied Health University of Oklahoma Health Sciences Center
Zhongjie Sun, MD, PhD Professor Department of Physiology College of Medicine University of Oklahoma Health Sciences Center Luke Szweda, PhD Hille Family Foundation Chair Member and Chair Free Radical Biology and Aging Research Program Oklahoma Medical Research Foundation Yusuke Takahashi, PhD Assistant Professor of Research Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Takemi Tanaka, PhD Associate Professor Department of Pathology College of Medicine University of Oklahoma Health Sciences Center Eleni Tolma, MPH, PhD Associate Professor Department of Health Promotion Sciences College of Public Health University of Oklahoma Health Sciences Center James Tomasek, PhD Vice President for Research University of Oklahoma Health Sciences Center David Ross Boyd Professor Department of Cell Biology College of Medicine University of Oklahoma Health Sciences Center Jeanie Tryggestad, MD Assistant Professor Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center
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54 2014 ANNUAL REPORT
MEMBERS (continued)
John Wenyu Wang, PhD Professor of Research Center of American Indian Health Research College of Public Health University of Oklahoma Health Sciences Center Weidong Wang, PhD Assistant Member Immunobiology and Cancer Research Program Oklahoma Medical Research Foundation Kiersten Weber, DPM Podiatrist Podiatry and Wound Care Harold Hamm Diabetes Center OU Physicians Diabetes and Endocrinology Clinic University of Oklahoma Health Sciences Center
Jian Xu, BS, MS, PhD Assistant Professor Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Yong Zhang, PhD Research Assistant Professor Department of Pharmaceutical Sciences College of Pharmacy University of Oklahoma Health Sciences Center Xin Zhang, MD, PhD Professor Department of Physiology College of Medicine University of Oklahoma Health Sciences Center
ASSOCIATE MEMBERS Rebecca Allen, MS, RD/LD, CDE Dietician, Diabetes Educator Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center
Joane Less, RN, BSN, MBA, CCRC Clinical Research Nurse Coordinator II Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center
Lacey Bixler, MS, RD/LD, CDE Clinical Trials Manager Clinical Trials Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center
Christy Olson, MS, RD, LD, CDE Diabetes Educator Diabetes Education and Self-Management OU Physicians Diabetes Life Clinic Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center
Dianne Brown, MS, RDN, LD, CDE Diabetes Educator Diabetes Education and Self-Management OU Physicians Diabetes Life Clinic Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center Catherine Carmichael Regulatory Compliance Specialist Clinical Trials Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center Jennifer Chadwick Native American Programs Coordinator Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center
Blessing Olufolake Olufowote, MS Research Project Coordinator CMRI Metabolic Research Program Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center Arthur Owora, MPH, CPH, DrPH Candidate Research Biostatistician College of Pharmacy University of Oklahoma Health Sciences Center Tawny Pantoja-Tucker Research Technician Clinical Trials Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center
MEMBERS
Michelle Phillips, MS, RCEP, CDE Exercise Physiologist and Certified Diabetes Educator Exercise Education and Research OU Physicians Diabetes Life Clinic Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center Wendy Ritchlin-Keller, AAS, CMA Medical Assistant and Patient Recruitment Specialist Clinical Trials and Prevention and Outreach Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center
Jessica Shaw, MS, RD/LD, CDE Clinical Research Coordinator II Clinical Trials Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center April Teague, MS Research Associate Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center
Jennifer Salazar, MPH Clinical Research Coordinator I Clinical Trials Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center
TRAINEE MEMBERS Aziz Ammara, MB, BS Fellow Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center
Dustin Masser, BS Graduate Research Assistant Doctoral Candidate Department of Physiology College of Medicine University of Oklahoma Health Sciences Center
Mei Du, MS Doctoral Candidate Department of Physiology College of Medicine University of Oklahoma Health Sciences Center
Victoria Sank, MS Predoctoral Intern Behavioral Health Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center
Evangelia Kalaitzoglou, MD Fellow Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine
Ian Schalo, AS, BS Graduate Research Assistant Pharmaceutical Science Graduate College University of Oklahoma Health Sciences Center
Lauren Labryer, MD Fellow Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center
Asitha Silva, MS Doctoral Candidate Physiological Science Center for Veterinary Health Science Oklahoma State University
Sang-Min Lee, PhD Postdoctoral Research Fellow Department of Biochemistry and Molecular Biology College of Medicine University of Oklahoma Health Sciences Center Ashley Martin, BS Doctoral Candidate Department of Physiology College of Medicine University of Oklahoma Health Sciences Center
Mitali Talsania, MD Fellow Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center
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CENTER AND PROGRAM LEADERSHIP & STAFF EXECUTIVE COMMITTEE Blake T. Rambo, JD, MBA Chief Operating Officer Chairman, Executive Committee Harold Hamm Diabetes Center Kenneth C. Copeland, MD Director Harold Hamm Diabetes Center-Children’s
David H. Jelley, MD Director Harold Hamm Diabetes Center-Tulsa James T. Lane, MD Director Harold Hamm Diabetes Center Adult Clinical Programs Jian-xing Ma, MD, PhD Director Harold Hamm Diabetes Center Research Programs
ADMINISTRATION Lance Leonard, MBA Business Administrator
Lori Bowman, MPA Development Officer
Patricia Parker Administrative Manager
Katie Hoefling Staff Assistant
Andy Behrens Assistant Director for Marketing
PATIENT EXPERIENCE & RESOURCE SERVICES Linda Butterfield Patient and Family Services Representative
BEHAVIORAL HEALTH Cynthia Muhamedagic, PhD Licensed Clinical Psychologist
Molly Fernando, PsyD Licensed Clinical Psychologist
ADULT CLINICAL TRIALS Lacey Bixler, MS, RD/LD, CDE Clinical Trials Manager
Cathy Carmichael IRB Administrator I
Jessica Shaw, MS, RD/LD, CDE Clinical Research Coordinator II
Tawny Pantoja-Tucker Research Technician
Jennifer Salazar, MPH Clinical Research Coordinator I
Wendy Ritchlin-Keller Medical Assistant
CENTER AND PROGRAM LEADERSHIP & STAFF
ADULT DIABETES EDUCATION AND SELF-MANAGEMENT Christy Olson, MS, RD/LD, CDE Diabetes Educator
Dianne Brown, MS, RD/LD, CDE Diabetes Educator
ADULT EXERCISE RESEARCH AND EDUCATION Michelle Phillips, MS, RCEP, CDE Exercise Physiologist
PODIATRY Kiersten Weber, DPM Podiatrist
PREVENTION, OUTREACH AND HEALTHY LIFESTYLE PROGRAMS Molly Fernando, PsyD Coordinator
Wendy Ritchlin-Keller Assistant Coordinator
OU PHYSICIANS DIABETES LIFE CLINIC Karen Groff, MSN, RN, BC, CNL Senior Clinic Administrator
LaVeeta Williams Patient Services Representative Team Lead
April Brawdy Clinic Manager
Jennifer Smith Patient Services Representative
OU PHYSICIANS DIABETES AND ENDOCRINOLOGY CLINIC Karen Groff, MSN, RN, BC, CNL Senior Clinic Administrator
Bettina Beard, MA Senior Medical Assistant
April Brawdy Clinic Manager
David Fredrick, MA Medical Assistant
Londa Hollowell APAC Manager
Hillarie Lehmberg Patient Services Representative
Melissa O’Hagan, LPN Lead Licensed Practical Nurse
Dannah Raissannejad Patient Services Representative
Dee Alvarado, LPN Licensed Practical Nurse
Robyn Roberts Patient Services Representative
HAROLD HAMM DIABETES CENTER-CHILDREN’S Rebecca Allen, MS, RD/LD, CDE Diabetes Educator
Shelley Fritch, RD/LD Dietician
Joni Beck, BC-ADM, PharmD, CDE Clinical Programs Director
Dana Gissandaner, BS Patient Services Representative
Jennifer Chadwick, BS Native American Programs Coordinator
Brenda Harrison Administrative Assistant
Sarah Dawson, RN, BSN, MA Pediatric Endocrinology Nurse Specialist
Jonna High, BS Senior Administrative Assistant and Fellowship Coordinator
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HAROLD HAMM DIABETES CENTER-CHILDREN’S (continued)
Steve Larson, CPA Business Manager
Megan Short Research Assistant
Joane Less, RN, BSN, MBA, CCRC Senior Clinical Research Nurse Coordinator
Kassidy Skinner, RN Registered Nurse
Shannon McEntire, AAS Medical Assistant
Shella Southern, BS Clinics Administrator
Amy Moore, RD/LD, CDE Certified Diabetes Educator and American Indian Coordinator
April Teague, MS Research Associate and Lab Manager
Kelle Dawn Overand, MS, APRN, CCNS-P, CDE Pediatric Clinical Nurse Specialist
Stephanie Viner, CMA-AAMA Medical Assistant
Jeff Preske, MA TODAY Study Program Coordinator
Hailey Vloedman, LPN, CMA-AAMA Licensed Practical Nurse
Traci Schaeffer, RN, BSN Endocrine Long Term Follow-up Coordinator and Nurse Educator
HAROLD HAMM DIABETES CENTER-TULSA Virgen Berrios-Minaya Medical Assistant
Candace Morgan Patient Service Representative
Cathey Colburn, MS, RN, CDE Diabetes Educator
Amy Puls, RD, LD, CDE Diabetes Educator
Michelle Condren, PharmD, CDE, Associate Professor Diabetes Educator
Jenny Owens Medical Assistant
Yevette Edmonds Patient Service Representative Dana Greer, APRN, CDE Nurse Practitioner Savannah Hans Patient Service Representative Steve Ludiker, APRN, CDE Nurse Practitioner
Tina Robinson Patient Service Representative Tracey Rowen Medical Assistant Shari Stevens, RN, CDE Diabetes Educator Joyce Wallace Patient Service Representative
HHDC CORE RESEARCH FACILITIES
Diabetic Animal Core
Histology and Imaging Core
Jian-xing Ma, MD, PhD Core Facility Director
James J. Tomasek, PhD Core Facility Director
ACTIVE GRANTS
ACTIVE GRANTS Essential Role of VLC-PUFA in Prevention of Retinal Degeneration Oklahoma Center for the Advancement of Science and Technology (OCAST). Agbaga, MP. 09/01/2014-06/30/2017 Retinal degeneration caused by alterations in protein O-sulfation NIH/NEI. Al-Ubaidi, M. 12/2014-11/2019 Lipid Metabolism in the Retina NIH. Anderson, R (PI); Le, Y. 07/01/2009-06/31/2014 Role of Very Long Chain Fatty Acids in the Aging Brain Reynolds Oklahoma Center on Aging. Anderson, R. 04/01/2013-03/31/2014 Pre-Eclampsia: Factors Conferring Risk and Protection in Minority Women with Dysglycemia National Institute on Minority Health and Health Disparities. Henderson, N; Lyons, T; Azar, M. 2012-2017 Development of an Intelligent Tutoring System on Using Diabetes Self-Monitoring Records to Improve Glycemic Control Lorraine D. Singer Foundation. Azzarello, J. 2012-2014 Metformin Therapy for Overweight Adolescents with Type 1 Diabetes Helmsley Charitable Trust. Copeland, KC; Beck, JK. 09/2013-present The Type 1 Diabetes (TID) Exchange Clinic Network JAEB Center for Health Research Foundation. Copeland, KC (PI); Beck, JK (Co-PI). 11/2010-present The Type 1 Diabetes (T1D) Exchange Network, TEENS Study Helmsley Charitable Trust. Copeland KC (PI); Beck JK (Co-PI). 04/2012-present TrialNet: Natural History Study of the Development of Type 1 Diabetes NIDDK, NIAID, NICHD, NCRR, JDRF, ADA. Copeland, KC; Beck, JK. 2004-present Self-Monitoring Artificial Vascular Graft NIH. Vilkomerson, D; Blebea, J. 2011-2015 Catheter-Mounted Device for Measuring Intravascular Flow and Pressure NIH. Vilkomerson, D; Blebea, J. 2011-2015 Mechanistic studies on obesity-deteriorated glucose and lipid metabolisms NI. Chan, CB.
Short-term outcomes of interventions for reproductive dysfunction NIH/NIDDK. Chernausek, S. 07/05/2013-04/30/2018 Studies to Treat or Prevent Pediatric Type 2 Diabetes Trial (STOPPT2D) NIH/NIDDK. Copeland, KC (PI); Chernausek (Co-PI). 09/01/2002-02/29/2014 Prenatal conditions and the pathway to obesity and diabetes in children NIH/NIDDK. Chernausek, S; Fields, D. 07/04/2010-06/30/2015 Treatment Options in Diabetic Adolescents and Youth (TODAY) NIH. Copeland, KC (PI); Tryggestad, J. 03/01/2012-02/28/2014 TODAY Genetics NIDDK/NIH. Copeland, KC (PI). 03/01/2012-02/28/2014 Incentivizing behavior: promoting more physical activity in American Indian youth NIH/NIMHD. Copeland, KC (PI). 06/01/2012-05/31/2017 Oklahoma Shared Clinical and Translational Resources National Institute of General Medical Sciences. James (PI); Copeland, KC (Sub-I). 09/01/2013-06/30/2018 A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents with Type 1 Diabetes Jaeb Center for Health Research, Inc. Copeland, KC (PI); Tryggestad, J. 05/01/2013-04/30/2015 Oral Insulin Prevention of Diabetes in Relatives At Risk for Type 1 Diabetes Mellitus NIH. Copeland, KC (PI); Tryggestad, J. 06/01/2012-05/31/2017 CTLA-4lg for Prevention of Abnormal Glucose Tolerance and Diabetes in Relatives at Risk for Type 1 Diabetes NIH. Copeland, KC (PI); Tryggestad, J. 10/24/2013-10/23/2020 Role of munc18-1 mutations in causing severe epilepsy and mental retardation OUHSC. Deak, F (PI). 02/2013-01/2014 Examining the Health Action Process Approach for predicting physical activity behavior in persons with low back pain North American Society for the Psychology of Sport and Physical Activity. Dionne, C (PI). 2014-2015 Role of Caveolin-1 in the Maintenance of Blood-Retinal Barrier Integrity NIH/NEI. Elliott. M (PI); Le, Y. 12/01/2009-11/30/2014
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ACTIVE GRANTS (continued)
Quantitative Proteomic Mapping of Diabetic Vasculature American Diabetes Association. Elliott, M (PI). 01/01/201312/31/2014 Manipulation of caveolae as a strategy for intraocular pressure regulation Alcon Research Institute Young Investigator Award. Elliott, M (PI). 07/01/2013-06/30/2014 Caveolins as novel mechanosensors in aqueous outflow BrightFocus National Glaucoma Research Award. Elliott, M (PI). 07/01/2013-06/30/2015 Role of Caveolin-1 in Limbal Stem Cell Biology Oklahoma Center for Adult Stem Cell Research. Cohen (coPI); Elliott, M (co-PI). 01/01/2013-12/31/2014 Altered signal processing in lipid rafts and synaptic dysfunction in brain aging Reynolds Center on Aging Collaborative Pilot Project Award. Deak, F (Co-PI); Elliott, M (Co-PI). 04/01/2013-03/31/2014 Vascular Permeability in Ocular Infections NIH/NEI. Callegan, M (PI); Elliott, M (co-PI). 01/14/201412/31/2017 Mentorship grant from the IDeA Network of Biomedical Research Excellence NIH. Espinoza-Varas, B. (PI) 5/1/2014-7/20/2014 The Impact of RBP4 Elevation on Endothelial Angiogenic Activity OUHSC College of Medicine Alumni Association. Farjo, K. 07/01/2013-03/31/2015 Investigating the Mechanism of RBP4-Induced Endothelial Inflammation American Heart Association. Farjo, K (PI). 09/01/201308/31/2015 Defining the Role of RDH10 in Retinal Pigment Epithelium Oklahoma Center for the Advancement of Science and Technology (OCAST). Farjo, K (PI). 09/01/2013-08/31/2016 Metabolic Derangements in GDM offspring: Role for Breast-Milk? Mead Johnson. Fields, D (PI). 06/01/2014-05/30/2015 Maternal obesity, breast milk composition and infant growth NIH/NICHD. Fields, D. (Co-PI); Demerath, E. (Co-PI). 04/01/2014-03/31/2019 Longitudinal Effect of Maternal Adiposity on Neonatal Adiposity Oklahoma Clinical and Translational Science Institute/ Oklahoma Shared Clinical and Translational Resource Pilot Grants program. Gunatilake, R; Myers, D; Fields, D (Co-I). 01/01/2014–06/30/2014
Does the Fetal Metabolic Profile at Birth Differ According to Treatment in Gestational Diabetes and Type 2 Diabetes During Pregnancy? OUHSC College of Medicine Alumni Association. Gunatilake, R; Myers, D; Fields, D (Co-I). 05/01/2013-06/30/2014 Genetic Determinants of Early Childhood Adiposity UNM HSC and OUHSC Consortium Inter-Institutional Pilot Project. Fields, D; Garver, W. 04/01/2013-05/31/2014 Effect of the level of dietary protein on infant growth and body composition in first year of life – Three and five year growth and body composition follow-up Nestle Nutrition. Fields, D (PI); Chernausek, S (Co-PI). 07/11/2011-06/10/2015 Association of single-nucleotide polymorphisms with body composition in children Harold Hamm Diabetes Center Linda Johnson Seed Grant. Fields, D (PI). 01/01/2011-12/31/2014 Metabolic Characterization of Human Milk in Mothers of Varying Body Mass Index Abbott Nutrition. Fields, D (PI). 02/01/2013-01/31/2014 Long-term follow-up of offspring exclusively breastfed Mead Johnson. Fields, D (PI). 08/01/2012-07/30/2014 Insulin therapy-resistant epigenetic alterations in diabetic retinopathy NEI/NIH. Freeman, W (PI). 2011-2015 Program for Multidisciplinary Research in Addiction PA CURE. Freeman, W (Co-I). 2011-2016 Persistent neuroepigenetic modifications caused by early-life endocrine factors Oklahoma Center for the Advancement of Science and Technology (OCAST). Freeman, W (PI). 2014-2017 High throughput quantitative PCR instrumentation Presbyterian Health Foundation. Freeman, W (PI). 2014-2015 Diet and exercise interventions to treat claudication University of Arkansas for Medical Sciences. Gardner, A (PI). 09/01/2013 -08/31/2014 Galectin-3: A potential novel biomarker for peripheral artery disease University of Oklahoma Clinical and Translational Science Institute. Gardner, A; Casanegra, A. 07/01/2014-06/30/2015 Cognitive function and endothelial oxidative stress in patients with peripheral artery disease Reynolds Oklahoma Center on Aging. Gardner, A (PI); 11/1/2014-10/31/2015
ACTIVE GRANTS
Abnormal intracellular calcium release in heart failure NIH/NILBI. Gyorke (PI); Lacombe, V. 12/01/2011-11/30/2016 Investigation of glucose regulation and insulin signaling pathways in endocrinopathic laminitis Animal Health Foundation. Lacombe, V (PI). 07/01/201207/30/2014 In Vivo Magnetic Resonance Spectroscopy in the Diabetic Myocardium Wentz Research Fellowship, Oklahoma State University. McPhearson, K; Lacombe, V. 08/2013-05/2014
Dr. Cynthia Muhamedagic, right, leads a patient session at Harold Hamm-Children’s Understanding the inflammatory processes of neurocysticercosis (NCC): a US-India partnership NIH. Carabin, H (PI); Hanas, J (Co-PI). 09/01/2011-12/31/2014 GRP78-Dependent Modulation of ER Stress Response in Diabetes NIH/NIGMS. Hays, F (PI). 07/01/2014-06/30/2015 Mitochondrial Dysfunction in Type 1 Diabetes NIH/CoBRE, Mentoring Diabetes Research in Oklahoma. Humphries, K (PI). 09/10/2012-06/30/2017 Dysfunctional PKA Signaling in the Diabetic Heart Oklahoma Center for the Advancement of Science and Technology (OCAST). Humphries, K (PI). 09/01/13-08/31/16 Acetylation of mitochondrial proteins increases ROS production in the diabetic heart American Heart Association. Humphries, K (PI). 07/01/1306/30/15 Dysregulated innate immune responses, chronic inflammation and osteoarthritis Children’s Hospital Foundation. Kalaitzoglou, E. (PI). 06/201306/2015 Role of CAP37 in Neuroinflammation: Friend or Foe? Oklahoma Center for the Advancement of Science and Technology (OCAST). Pereira, HA (PI); Kasus-Jacobi, A. 07/01/2012-06/30/2015 Activating Autoantibodies in Orthostatic Hypotension AHA. Li, H (PI); Kem, D. 07/01/2012-06/30/2014 Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors OUHSC. Kem, D (PI) 2013-2014 The novel role of TLR4 during cardiac insulin resistance Oklahoma State University Seed Grant; Lacombe, V (PI). 09/10/2013-10/31/2014
SCALE™ - Diabetes: Satiety and Clinical Adiposity -Liraglutide Evidence in Nondiabetic and diabetic Subjects - Effect of liraglutide on body weight in overweight or obese subjects with type 2 diabetes: A 56 week randomised, double-blind, placebo-controlled, three armed parallel group, multi-centre, multinational trial with a 12 week observational follow-up period Novo Nordisk. Lane, J (PI). 05/23/2011-05/22/2014 LEADER – Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results – A Long-term, Multi-center, International, Randomized Double-Blind, Placebo-controlled Trial to Determine Liraglutide Effects on Cardiovascular Events Novo Nordisk. Lane, J (PI). 08/25/2010-08/24/2015 A prospective, randomized, placebo-controlled, double-blind clinical trial to evaluate whether EGRIFTA® (tesamorelin for injection), 2 mg once daily SC, increases the risk of development or progression of diabetic retinopathy when administered to HIVinfected subjects with abdominal lipohypertrophy and concomitant diabetes EMD Serono, Inc. Lane, J (PI). 09/15/2012-09/14/2015 A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess Cardiovascular Outcomes Following Treatment with MK-3102 in Subjects with Type 2 Diabetes Mellitus Merck Sharp & Dohme Corp. Lane, J (PI). 11/15/201211/14/2015 A long-term, randomized, double-blind, placebo-controlled, multinational, multi-center, trial to evaluate cardiovascular and other long-term outcomes with semaglutide in subjects with type 2 diabetes Novo Nordisk. Lane, J (PI). 01/17/2013-present
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ACTIVE GRANTS (continued)
Two Treatment Approaches for Human Regular U-500 Insulin (Thrice-Daily versus Twice-Daily) in Subjects with Type 2 Diabetes Mellitus Not Achieving Adequate Glycemic Control on High-Dose U-100 Insulin Therapy with or without Oral Agents: A Randomized, Open-Label, Parallel Clinical Trial Eli Lilly and Company. Lane, J (PI). 01/24/2013-present
Interaction of notch and Wnt pathway in diabetic retinopathy The International Retinal Research Foundation. Zhang, S (PI); Ma, J-x (collaborator). 11/01/12-10/31/14
A comparison of LY2605541 once daily at a fixed time with LY2605541 variable time of dosing in patients with type 1 diabetes mellitus: An open label, randomized, crossover study Eli Lilly and Company. Lane, J (PI). 02/08/2013-present
A novel humanized antibody blocking the Wnt pathway for the treatment of diabetic retinopathy Juvenile Diabetes Research Foundation (JDRF). Ma, J-x. 08/01/2014-07/31/2016
Mentoring diabetes research in Oklahoma NIH/NIGM/COBRE. Le, Y (PI). 09/10/2012-06/30/2017
Pathogenic Role of Wnt Signaling in Diabetic Nephropathy Oklahoma Center for the Advancement of Science and Technology (OCAST). Ma, J-x. 10/01/2013-09/30/2017
Sphingolipid Metabolism and Signaling in the Retina NEI/NIH. Mandal, N. 04/01/2012-03/31/2017 Lipid Metabolism in the Retina.
De Novo Regeneration of Retinal Cells in Diabetes Oklahoma Center for Adult Stem Cell Research. Le, Y (PI). 07/01/2014-06/30/2015
National Eye Institute. Anderson, RE (PI); Mandal, N (Co-I). 07/01/2009-06/30/2014
Study of RPE barrier NIH/NEI. Le, YZ (PI); Elliott, M (Co-PI). 09/01/201008/31/2014
Molecular mechanisms of dietary omega-3 effects on the obesityassociated diseases and the maintenance of cognitive integrity Internal Department Bridge Funding. Matsumoto, H. 07/01/2013-09/30/2014.
Pathobiology of retinal neurons Presbyterian Health Foundation. Le, Y (PI). 10/01/201409/30/2015 Retinal degenerative diseases funds Allergan, Inc. & Hope for Vision Le, Y. (PI) 01/01/2007-present AMPK as a redox sensor and modulator NIH/NHLBI. Zou, MH (PI); Le, Y. 09/12/2012-06/30/2017
Associated variables of the parent-child relationship and how they impact patient diabetes management Muhamedagic, C. 2013-Present Health Outcomes in a Young Adult Clinic for Patients with Diabetes Lane, J; Muhamedagic, C. 2012-Present
ER stress and diabetic retinopathy NIH/NEI. Zhang, X (PI); Le, Y. 09/01/2010-08/31/2015
Psychosocial Impact on Glycemic Control in Patients with Type 2 Diabetes Lane, J; Muhamedagic, C. 2013-Present
AMP-activated protein kinase in diabetes NIH/NIHLB. Zou, MH (PI); Le, Y. 02/01/2012-01/31/2016
Mechanisms of Acclimatization: Fetus and Adult NIH. Myers, D. 08/01/2010-07/31/2015
Role and mechanism of inflammatory factor Nogo-B in the pathogenesis of diabetic retinopathy National Natural Science Foundation of China. Wang, J. (PI); Le, Y. 01/01/2013-12/31/2015
Impact of long term hypoxia during gestation on adipose function in the lamb Presbyterian Health Foundation Bridge Grant; Myers, DA (PI). 10/01/2014-09/30/2015
Mentoring Diabetes Research in Oklahoma NIH. Ma, J-x. 09/10/2012-06/30/2017
Mechanism of maternal dietary imbalance and obesity on fetal and infant adiposity Presbyterian Health Foundation Seed Grant. Gunatilake, R (PI); Myers, DA (Co-I). 10/01/2014-9/30/2015
A novel pathogenic mechanism for diabetic retinopathy NIH. Ma, J-x. 03/01/2012 to 02/29/2018 The role of the wnt signaling pathway in choroidal neovascularization NIH. Ma, J-x. 08/01/2011-07/31/2015
Genetic Analysis of Zebrafish Glomerulus Disease and Development Presbyterian Health Foundation. Obara, T. 10/01/201409/31/2015
ACTIVE GRANTS
Role of Wtip in Chronic Kidney Disease Oklahoma Center for the Advancement of Science and Technology (OCAST). Obara, T. 09/01/2014-08/31/2017 Pathogenesis and cure of obesity-related-glomerulopathy (ORG) by omega-3 OUHSC Seed grant. Obara, T. 03/01/2014-02/28/2015 Regulation of Ca2+ signaling by the polycystic kidney disease 2 gene product NIH. Tsiokas; L; Obara, T. 09/01/2011-08/31/2015 Metabolic Regulation of GLUT4 Gene Expression NIH. Olson, A. 06/01/2009-05/31/2014 Metabolic fate of GLUT4-dependent glucose uptake in lean and diet-induced obese mice Presbyterian Health Foundation. Olson, A. 10/01/201409/30/2015 Efficacy and Tolerability of Magnesium Plus Protein For Managing Hypomagnesaemia in Pediatric Kidney Transplant Patients Miller Pharmacal Group, Inc. Martin Turman, M.; Owora, A. 2014-2015 Acceptability and feasibility of a nutrition intervention among African Americans with diabetes Oldways. Hall, M; Owora, A. 2014-2015 Integration of Diabetes Self-Management Education into a PatientCentered Medical Home American Association of Diabetes Educators. Letassy, N; Owora, A. 2014-2015
Dr. Albina Gosmanova conducts an exam in our adult clinic
Obesity in Early Childhood among Oklahoma American Indian Tribal Children. Oklahoma Center for the Advancement of Science and Technology (OCAST). Weedn, A; Owora, A. 2014-2015 Maternal, Infant, and Early Childhood Home Visiting Competitive Grant Program Health Resources and Services Administration (HRSA). Bard, D; Owora, A. 2011-2015 Stroke and Coated-Platelets - A Translational Research Initiative Department of Veterans Affairs Merit Review Program. Prodan, C. 04/01/2011-03/31/2015 Light Activation of Retinal Insulin Receptor Signaling NIH/NEI. Rajala, R. 09/01/2010-08/31/2015 Second Messengers in Retina NIH/NEI. Rajala, R. 04/01/2014-03/31/2015 Light Activation of Retinal Insulin Receptor Signaling Presbyterian Health Foundation. Rajala, R. 09/01/201408/31/2015
Dr. Richard Hellman, left, of Kansas City, accepts appreciation from Harold Hamm’s Dr. James Lane, right, after his Lecture Series presentation, Oct. 2014
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ACTIVE GRANTS (continued)
Harold Hamm (center, in blue) is recognized with applause at our Fall Open House, Oct. 2014 Interaction of Genotype and Level of Dietary Restriction on Lifespan and Aging National Institute on Aging, Richardson, A. 2014-2019
American Indian diabetes prevention center: Impacting health disparity in youth NIH/NIMHD Henderson, N. (PI)
Nathan Shock Center on Excellence in Basic Biology of Aging National Institute on Aging. Richardson, A. 2010-2015
Subproject: Incentivizing behavior: Promoting more physical activity in American Indian youth Copeland, KC (Co-PI); Short, KR (Co-PI). 06/01/201205/31/2017
Does overexpressing Cu/ZnSuperoxide Dismutase Retard Aging in High-Fat Fed Mice? VA Merit Review. Richardson, A. 2010-2014 Tribal Health and Resilience in Vulnerable Environments (THRIVE) National Health Lung and Blood Institute (NHLBI), Jernigan, V; Salvatore, A. 2013-2018 GWAS follow-up studies of type 2 diabetes in South Asians OUHSC. Sanghera, D. 03/01/2013-11/01/2014 Genome-wide association studies to identify risk genes for type 2 diabetes NIH/NIDDK. Sanghera, D. 09/01/2009-08/31/2015 Mitochondrial matrix protease ClpP in aging and cell survival American Federation for Aging Research. Sathyaseelan, D. 07/2013-06/2015 Mitochondrial matrix protease ClpP in development NIH COBRE. Sathyaseelan, D. 07/2014-02/2015 Molecular mechanisms of mitochondrial stress modulated insulin sensitivity American Heart Association. Sathyaseelan, D. 01/2013-12/2014
Continuous glucose monitoring in low physical activity youth with and without type 2 diabetes OUHSC Department of Pediatrics. Dasari, P; Short, K. 07/01/2012-06/30/2014 Continuous glucose monitoring in low physical activity youth with and without type 2 diabetes Medtronic Medical. Short, K. 12/14/2012-05/31/2014 To determine whether osteocalcin is associated with changes in insulin sensitivity following meals and exercise in young men. University of Oklahoma. Sunderland, K; Short, K. 02/01/201301/31/2014 Child Care Classroom Observation: Ability to Predict an Obesogenic Environment IT3. Landers, P; Sisson, S. 01/2013-12/2014 Preventing Obesity in Young Children: Formative Development of Interdisciplinary Obesity Prevention Intervention for Early Childhood Sisson, S; Cheney, M; Jacob, A; 07/01/2014-06/30/2015
Comparison of Two Screening Strategies for Gestational Diabetes NIH. Davis; Scifres, C. 09/25/2014-05/31/2019
Investigation into cold-induced pulmonary vascular inflammation and dysfunction NIH. Sun, Z. 08/16/2013-06/30/2017
Prenatal conditions and the pathway to obesity and diabetes in children NIH/NIDDK. Chernausek, S; Short, K. 08/04/2010-05/31/2015
Molecular mechanism of kidney aging NIH. Sun, Z. 06/26/2012-05/31/2017 Regulation of blood pressure by klotho NIH. Sun, Z. 02/15/201-01/31/2015
ACTIVE GRANTS
Molecular mechanism of arterial stiffening NIH. Sun, Z. 09/20/201-12/31/2015 Anti-aging gene klotho: A novel therapeutic target for calcific aortic valve disease NIH. Sun, Z. 03/01/2014-02/28/2018 Interdisciplinary Research in Vascular Biology NIH/CoBRE. Szweda, L. 07/01/2010-04/30/2015 Mentoring Diabetes Research in Oklahoma, National Institutes of Health CoBRE Grant. Szweda, L. 10/15/2012-06/30/2017 Expanding Excellence in Developmental Biology in Oklahoma National Institutes of Health CoBRE Grant. Szweda, L. 03/01/2013-02/28/2018 A new pathogenic mechanism for diabetic retinopathy NIH. Takahashi, Y. 03/01/2013-03/31/2018 Regulatory Role of MicroRNA-184 in Diabetic Retinopathy OCAST. Takahashi, Y. 7/01/2012-06/30/2015 A novel humanized antibody blocking the Wnt pathway for the treatment of diabetic retinopathy. Juvenile Diabetic Research Foundation. Takahashi, Y. 02/01/2014-01/31/2016 Oklahoma Shared Clinical Translational Resources (OSCTR): Clinical research education, mentoring, and career development Key Component Activity NIH. James; George; Tomasek, J; Williams; Tolma, E. 09/01/2013-06/30/2017
Developing a new version of TALEN gene-editing technology for gene therapy and biomedical research Oklahoma Center for the Advancement of Science and Technology (OCAST). Wang, W. 09/01/2013-08/31/2015 Pancreatic β Cell Differentiation from Human IPS Cells Oklahoma Center for the Advancement of Science and Technology (OCAST). Wang, W. 07/01/2012-06/30/2015 Understanding diabetes pathogenesis using patient-specific human iPS cells Oklahoma Center for Adult Stem Cell Research. Wang, W. 01/01/2014-12/31/2014 Expanding Excellence in Developmental Biology in Oklahoma Project 5: Derivation of pancreatic beta cells from human induced pluripotent stem cells NIH/NIGMS. Thompson; Wang, W. 3/01/2013-02/28/2018 Inhibition of AMPK in diabetes Fish Oil and AMP-Activated Protein Kinase in Endothelium Oklahoma Center for the Advancement of Science and Technology. Xie, Z. 08/01/2012-07/31/2015 AMP-activated protein kinase in diabetes NIH. Zou, M; Xie, Z. Role of ULK1 in Diabetic Impairment of Angiogenesis Oklahoma Center of Advancement of Science and Technology (OCAST). Xu, J. 9/01/2014-08/30/2017 Role of endothelial autophagy in diabetes-induced angiogenesis impairment American Heart Association. Xu, J. 07/01/2014-06/30/2016
Regulation of Myofibroblast Formation in Wound Healing Oklahoma Center for the Advancement of Science and Technology (OCAST). Tomasek, J. 07/01/2012-09/01/2014
The role of eNOS-derived nitric oxide in the regulation of 26S proteasome functionality in diabetes American Diabetes Association. Xu, J. 01/01/2012-12/31/2014
Fibroblast Differentiation in Wound Healing NIH. Tomasek, J. 09/01/2014-07/31/2018
Diabetes, 26S proteasomes and caloric restriction Oklahoma Center of Advancement of Science and Technology. Xu, J. 07/01/2011-06/30/2014
Mentoring Diabetes Researchers in Oklahoma NIH. Tomasek, J. 09/15/2007-06/30/2017 Comparison of micro-RNA microarray results between umbilical cord endothelial cells and serum of children Oklahoma Shared Clinical and Translational Resources. Tryggestad, J. 07/01/2014-06/30/2015 Comparison of circulating miRNA in normal weight, obese, and type 2 diabetic children OUHSC. Tryggestad, J. 03/01/2013-02/28/2014 Discovering small molecules that protect beta cells against ER stress-induced death for treatment of diabetes Oklahoma Center for the Advancement of Science and Technology. Wang, W. 09/01/2013-08/31/2016
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PUBLICATIONS Logan, S, Agbaga, MP, Chan, MD, Brush, RS, and Anderson, RE (2014). Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity. J Lipid Research, 2014 Feb 25. Epub ahead of print doi: 10.1194/jlr.M045443.
Murray, A.R., Vuong, L., Brobst, D., Fliesler, S.J., Peachey, N.S., Gorbatyuk, M.S., Naash, M.I. and Al-Ubaidi, M.R. (2014) Rhodopsin’s glycosylation is necessary for its stability and incorporation into photoreceptor outer segment discs. Submitted to Human Molecular Genetics.
Mandal, NA, Tran J-TA, Zheng L, Wilkerson JL, Brush RS, McRae J, Agbaga MP, Zhang K, Petrukhin K, Ayyagari R, Anderson RE (2014). In vivo effect of mutant ELOVL4 on the expression and function of wild type ELOVL4. Accepted by Invest Ophthalmol Vis Sci.
Azadi S, Anderson RE and Rajala RVS (2014) Class I Phosphoinositide 3-Kinase exerts a differential role on cell survival and cell trafficking in retina. Advances in Experimental Biology and Medicine. In press.
Agbaga MP, Logan S, Brush RS, Anderson RE (2014). Biosynthesis of Very Long-Chain Polyunsaturated Fatty Acids in Hepatocytes Expressing ELOVL4. Adv Exp Med Biol. 2014; 801:631-6. Agbaga MP, Tam BM, Wong JS, Yang LL, Anderson RE, Moritz OL. (2014). Mutant ELOVL4 that causes autosomal dominant Stargardt-3 macular dystrophy is misrouted to rod outer segment disks. Invest Ophthalmol Vis Sci. 2014 May 15. pii: IOVS-13-13099. doi: 10.1167/iovs.13-13099. Kanan, Y., Brobst, D., Han, Z., Naash, M.I. and Al-Ubaidi MR (2014) Fibulin 2, a tyrosine O-sulfated protein is up-regulated following retinal detachment. J. Biol. Chem. 289:13419-13433. Conley, S.M., Al-Ubaidi MR, Han, Z. and Naash, MI (2014) Rim formation is not a prerequisite for distribution of cone photoreceptor outer segment proteins. FASEB J 28:3468-79. Chakraborty, D., Conley, S.M., Al-Ubaidi, MR and Naash, M.I. (2014) Initiation of rod outer segment disc formation requires RDS. PLoS One 9: e98939. Kanan, Y., Siefert, J.C., Kinter, M. and Al-Ubaidi, M.R. (2014) Complement Factor H, Vitronectin and Opticin are TyrosineSulfated Proteins of The Retinal Pigment Epithelium. PLoS One e105409. Mitra, R.N., Merwin, M.J., Han, Z., Conley, S.M., Al-Ubaidi, M.R. and Naash, M.I. (2014) Yttrium oxide nanoparticles prevent photoreceptor death in a light-damage model of retinal degeneration. Free Radical Biology and Medicine 75C:140-148. Kanan, Y., Gordon, W.C., Mukherjee, P.K., Bazan, N.G. and Al-Ubaidi, M.R. (2014) Neuroprotectin di is synthesized in the cone photoreceptor cell line 661w and elicits protection against light-induced stress. Cellular and Molecular Neurobiology. Epub ahead of print.
Jenkins, A.J., Fu, D., Azar, M., Stoner, J.A., Kaufman, D.G., Zhang, S, Klein, R.L., Lopes-Virella, M.L., Ma, J-x., Lyons, T.J. and VADT investigators. (2014) Clinical Correlates of Serum Pigment Epithelium-Derived Factor in Type 2 Diabetes Patients. J. Diabetes and Its Complications. 28:353-9. PMCID:PMC4009500. Azzarello, J. & Westfall, S. (July 2014 volume 63). Latent knowledge underlying interpretation of blood glucose monitoring records. Diabetes, pp A4. Hoffhines H, Whaley KD, Blackett PR, Palumbo K, Glore S and Lee ET. Early Childhood Nutrition in a Plains Indian Community: Educational Strategy for Obesity Prevention. J Oklahoma State Medical Association. 2;55-59, 2014. Blackett PR, Sanghera DK. Distinct Genetic Backgrounds in Quantitative Traits Preceding Type 2 Diabetes: One Reason for Missing Heritability. British Journal of Medicine and Medical Research, 4(2), 590620, 2014. Blackett PR. Efficacy and Safety of Pre-Meal Orlistat to Augment a Low Fat Diet for Severe Hypertriglyceridemia (Expert Opinion, open access peer reviewed, by invitation) Journal of Symptoms and Signs 3 (3): 172.177, 2014. Wilson DP, McNeal CM, Blackett PR. Pediatric Lipid Screening – Guidelines and Controversies. Southern Med J, accepted 2014. Blackett PR, McNeal C and Wilson DP Evidence-Based Medicine Tools for Practice: Triglyceride and Atherogenic Dyslipidemia in Adolescence. Lipid Spin (Official Publication of the National Lipid Association). In press 2014. Wilson DP, McNeal C, Blackett PR. Severe hypertriglyceridemia in a 6 month old child. National Lipid Association. RealCME, July 2014.
PUBLICATIONS
Certified Diabetes Educator Christy Olson leads a group class in diabetes self-management Sapokota B, Subramanian A, Blackett P, Sanghera DK. Role of APOE genotypes in predicting cardiometabolic outcomes in individuals with metformin-sulfonylurea combination therapy. 8th Annual Department of Pediatrics Research Day, May 2014.
Jennings WC, Mallios A, Blebea J. Upper Extremity Permanent Hemodialysis Access Placement. In Darling RC, Ozaki CK (eds): MASTR TECHNIQUES IN SURGERY:VASCULAR SURGERY. Philadelphia: Lippincott Williams & Wilkins. In Press.
Mallios A, Boura B, Combes M, Blebea J. Abdominal aortic coarctation in a middle aged adult. J Vascular Surgery. In press.
Blebea J. Discussion of Lurie F et al. Clinical outcomes and cost effectiveness of initial treatment strategies for nonembolic acute limb ischemia in real life clinical settings. J Vasc Surg In press.
Mallios A, Taubman K, Claiborne P, Blebea J. Subclavian Vein Stent Fracture and Venous Motion. Ann Vascular Surgery. Submitted. Blebea J. The Sunshine Act and its Effects on Physicians and Continuing Education. Vein 7(1):26-28, 2014. Papazoglou K, Mallios A, Antoniadis P, Karkos K, Staramos D, Dervisis K, Blebea J. Endovascular repair of ruptured abdominal aortic aneurysms with the Endurant stent graft. J Vascular Surgery Submitted. Mallios A, Brown R, Blebea J. Axillary Artery Deployment of EVAR Iliac Limb for Preservation of Internal Iliac Artery Blood Flow. J Vascular Surgery. Submitted. Blebea J. Intraoperative Recognition and Treatment of Cerebral Ischemia During Carotid Endarterectomy. In Stanley JC, Wakefield TW, Veith FJ (eds). CURRENT THERAPY IN VASCULAR AND ENDOVASCULAR SURGERY. Philadelphia: B.C.Decker, 2014.
Blebea J. Discussion of Kougias P et al. A randomized controlled trial of domain specific cognitive function after carotid endarterectomy and stenting. J Vasc Surg. In press. Blebea J. Discussion of Sgroi M et al. Vascular reconstruction plays an important role in the treatment of pancreatic adenocarcinoma. J Vasc Surg. In press. Blebea J. Discussion of Gillespie D et al. Civilian/military collaboration in the management of military vascular trauma: a 10year report of the SVS volunteer program. J Vasc Surg. In press. Blebea J. Discussion of Coleman D et al. The contemporary guidelines for asymptomatic renal artery aneurysms are too aggressive: a North American experience. J Vasc Surg. In press.
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Chadwick JQ, Copeland KC, Daniel MR, Erb-Alvarez JA, Felton BA, Khan SI, Saunkeah BR, Wharton DF, and Payan ML, Partnering in Research: A National Research Trial Collaborating Effectively with American Indian Nations and the Indian Health Service. American Journal of Epidemiology 2014;180(12):1202-7. Liu X, Obianyo O, Chan C.B., Huang J, Xue S, Yang J, Zheng F, Goodman M & Ye K. 2014 Biochemical and biophysical investigation of brain-derived neurotrophic factor mimetic 7,8-Dihydroxyflavone in binding and activation of TrkB receptor. Journal of Biological Chemistry 289: 27571-27584. Qiang G, Xue S, Yang J, Du G, Pang X, Li X, Goswami D, Griffin P, Ortlund E, Chan C.B. & Ye K. 2014 Identification of a small molecular insulin receptor agonist with potent antidiabetic activity. Diabetes 63: 1394-1409. Chan C.B., Liu X, Zhao L, Liu G, Lee C.W., Feng Y and Ye K. 2014 PIKE is essential for oligodendroglia development and CNS myelination. Proceedings of the National Academy of Sciences USA 111: 1993-1998. Chernausek SD, Arslanian S, Caprio S, Copeland KC, El ghormli L, Kelsey M, Koontz M, Orsi C and Wilfey D: Impact of Maternal Diabetes During Pregnancy on Adolescents with Type 2 Diabetes (T2D): Results from the TODAY Study. In preparation. Zhang Z, Liu X, Schroeder J, Chan C.B., Song M, Yu S.P., Weinshenker D and Ye K. 2014 7,8-Dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s disease. Neuropsychopharmacology 39: 638-650.
Phillips DL, Hager JL, Goins KM, Kitzmann AS, Greiner MA, Cohen AW, Welder JD, Wagoner MD. Boston Type 1 Keratoprosthesis for Chemical and Thermal Injury. Cornea. 2014 Sep;33(9):905-9. Brown CR, Wagoner MD, Welder JD, Cohen AW, Goins KM, Greiner MA, Kitzmann AS. Boston keratoprosthesis type 1 for herpes simplex and herpes zoster keratopathy. Cornea. 2014 Aug;33(8):801-5. Gu, X, Fliesler, SJ, Zhao, Y, Stallcup, WB, Cohen, AW, Elliott, MH. Loss of Caveolin-1 Causes Blood-Retinal Barrier Breakdown, Venous Enlargement and Mural Cell Alteration. Am. J. Path. 2014 Feb.184(2):541-55. PMID: 24326256. Zeitler PS, Geffner ME and Copeland KC, Crisis in research – Clinical trials in youth with Type 2 diabetes mellitus. Submitted. Copeland KC and Shay C: The epidemic of type 2 diabetes in youth: what can China expect? J Clin Pediatrics. Submitted. Zeitler PS, Copeland KC, Hirst K, Katz L, Linder B, McGuigan P, White N, Wilfley D, Determinants of durable glycemic control among adolescents with type 2 diabetes. In preparation. Davis, N. Designing a Robust Analytics Platform for the Analysis of Community Health Outcomes. 20th ACM SIGKDD Conference on Knowledge Discovery and Data Mining, Workshop on Health Informatics. ACM, New York, NY, USA, doi:10.13140/2.1.3721.6648, August 2014.
Boyce, TM, Early, K, Chan, A, Cohen, AW. Copper deposits in a patient with multiple myeloma. Submitted. Hager, JL, Phillips, DL, Goins, KM, Kitzmann AS, Greiner MA, Cohen AW, Welder JD, Wagoner MD. Boston Type 1 Keratoprosthesis for Failed Keratoplasty. Int. Ophth. Accepted for publication. Li X, Gu X, Boyce TM, Zheng M, Reagan AM2, Qi H, Mandal N, Cohen AW, Callegan MC, Carr DJ, Elliott MH. Caveolin-1 Increases Pro-inflammatory Chemoattractants and Blood-Retinal Barrier Breakdown but Decreases Leukocyte Recruitment in Inflammation. Invest Ophthalmol Vis Sci. 2014 Aug 26. Gu, X., Reagan, A., Yen, A., Bhatti, F., Cohen, A.W., and Elliott, M.H. (2014) Spatial and temporal localization of caveolin-1 protein in the developing retina. Adv. Exp. Med. Biol. 801: 15-21.
Dr. David Jelley, director of Harold Hamm-Tulsa, presents at Beyond the Basics, May 2014
PUBLICATIONS
Dionne CP, Ertl WJJ, Day JD, Smith BJ, Commuri S, Regens JL, Mai A. (2014). A cross-sectional study of residuum measures during gait and work-related activities in men with transtibial amputation due to a traumatic event. Journal of Prosthetics and Orthotics,26 3, 128-133. Dionne, C.P., LaRosa Aranda, M., Crawford, D.A., Ertl, W.JJ. (2014). Examination of work-related activity performance in selected men with traditional or osteomyoplastic transtibial amputation due to trauma. Journal of Orthopaedic Physical Therapy Practice. Submitted.
Dr. Molly Fernando speaks with a TV journalist about diabetes prevention Deák F. Neuronal vesicular trafficking and release in agerelated cognitive impairment. J Gerontol A Biol Sci Med Sci. 2014 May 7, doi:10.1093/gerona/glu061. PMID: 24809352. Liu CC, Tsai CW, Deák F, Rogers J, Penuliar M, Sung YM, Maher JN, Fu Y, Li X, Xu H, Estus S, Hoe HS, Fryer JD, Kanekiyo T, Bu G. Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease. Neuron. 2014 Sep 17. pii: S08966273(14)00749-1. doi: 10.1016/j.neuron.2014.08.048. PMID: 25242217. Abel NA, De Sousa EA, Govindarajan R, Simpson DA. Guidelines for Ethical Behavior Relating to Clinical Practice Issues in Neuromuscular & Electrodiagnostic Medicine. Muscle & Nerve 2014 Submitted. Thawani SP, Tanji K, De Sousa EA, Weimer LH, Brannagan TH. Bortezomib. Associated Demyelinating NeuropathyClinical and Pathological Features. 2014. Submitted. De Sousa EA, Lee K. Critical Illness Polyneuropathy and Myopathy in Frontera J (Ed.), Decision Making in Neurocritical Care, Thieme New York, Second Edition 2014. De Sousa EA. Neuropathies, Overview, in Aminoff & Daroff, Encyclopedia of Neurological Sciences, 2nd Edition, Elsevier, June 2014.
Dionne, C.P., Smith, B.J., Commuri, S., Day, J.D., Ertl W.J.J., Regens, J.L. (2014). Changes in work-related performance in men with osteomyoplastic transtibial amputation over a 12-month timeframe. In manuscript. Dionne, C.P., Smith, B.J., Ashikayan, O., Martin, M., Li, S. and Fung, T. (2014). Pilot study: Characteristics of lumbar disc disease in patients who centralize symptoms. Journal of Manual and Manipulative Therapy. Submitted. Crawford, D.A., Hamilton, T.H., Dionne, C.P. (2014) Barriers and Facilitators to Participation in Physical Activity and Exercise: A Qualitative Perspective from the Trans-tibial Amputee Population. Physical Therapy. Submitted. Fu D, Yu Y, Wu M, Du M, Chen J, Boulton ME, Ma J-X, Lopes-Virella, MF, Virella G, Lyons TJ. Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytes. Journal of Lipid Research 2014;55:860-869. Du, M. †, Elliott, M.H. †, Wu, M., Fu, D., Yang, S., Basu, A., Gu, X., Ma, J.X., Aston, C.E., and Lyons, T.J. Extra-vascular modified LDL accelerates diabetic retinopathy. In revision. † indicates equally contributing first authors Bhatti, F., Ball, G., Hobbs, R., Linens, A., Munzar, S., Akram, R., Elliott, M., Barber, A.J., Anderson, M., and Edwards, M. (2014) Pulmonary surfactant protein A is expressed in the mouse retina by Müller cells and impacts neovascularization in oxygen induced retinopathy. Invest. Ophthalmol. Vis. Sci. In press.
DeSousa EA, Weimer LH. Overview of small fiber neuropathies. Original manuscript: 2010, updated 2014 In: Gilman S, editor. MedLink Neurology. San Diego: MedLink Corporation. Available at www.medlink.com.
Bennett L.D., Brush, R.S., Chan, M., Lydic, T.A., Reese, K., Reid, G.E., Busik, J.V. Elliott, M.H., and Anderson, R.E. (2014) Effect of reduced retinal VLC-PUFA on rod and cone photoreceptors. Invest. Ophthalmol. Vis. Sci. 55: 3150-3157. PMCID:PMC4027810.
DeSousa EA Weimer LH. Nutrition-related neuropathies, Original 2012. In: Gilman S, editor. MedLink Neurology. San Diego: MedLink Corporation. Updated 2014. Available at www.medlink.com.
Reagan, A., Gu, X., Hauck, S.M., Ash, J.D., Cao, G., Thompson, T.C., and Elliott M.H. (2014) Retinal caveolin-1 modulates neuroprotective signaling. Adv Exp Med Biol. Submitted. Nag, O, Elliott, MH, Gu, X, Cohen, AW. Loss of Caveolin-1 Results in Reduced Corneal Scar Formation. In preparation.
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Clinical Trials staffers Lacey Bixler and Wendy Ritchlin-Keller represent the center at an outreach event
Elliott, M.H., Gu, X., Ashpole, N.E., Griffith, G.L., Boyce, T.M., Tanito, M., Tamm, E.R., and Stamer, W.D. Role of caveolin-1 in intraocular pressure and conventional outflow regulation. In preparation. Hauck, S.M., Dozmorov, M., McClellan, M.E., Wren, J.D., and Elliott, M.H. Proteomic profiling of caveolae from aqueous outflow tissue. In preparation. Gu, X., Cohen, A.W., Zhao, Y.Y., Minshall, R.D., and Elliott, M.H. Endothelial-specific ablation of caveolin-1 induces cardiopulmonary dysfunction. In preparation. Elliott, M.H., Nag, O., Griffith, G., Gu, X., Boyce, T.M., and Cohen, A.W. Loss of caveolin-1 promotes corneal epithelial wound healing. In preparation. Gu, X., Gurung, H.R., Zheng, M., Carr, D.J., and Elliott M.H. Caveolin-1 promotes corneal lymphangiogenesis. In preparation. Wisniewski, A.B., Espinoza-Varas, B., Aston, C. E., Edmundson, S., Champlin, C. A., Pasanen, E. G., McFadden, D. (2014). Otoacoustic emissions, auditory evoked potentials and self-reported gender in people affected by disorders of sex development (DSD). Hormone & Behavior, 66, 467-474. Bingabr, M. G., Espinoza-Varas, B., Sigdel, S. (2014). Measurements of monopolar and bipolar current spreads using forward-masking with a fixed probe. Cochlear Implants International, 15, 166-172. Casazza, K., L. Hanks and D. Fields (2014). The relationship between bioactive components in breast milk and bone mass in infants. BoneKEy. Rep 3:577. PMID: 25328673.
Casazza K, A. Brown, A. Astrup , F. Bertz, C. Baum , M. Bohan Brown, J. Dawson, N. Durant, G. Dutton, D. Fields, K. Fontaine, D. Levitsky, T. Mehta, N. Menachemi, P. Newby, R. Pate, H. Raynor, B. Rolls, B. Sen, D. Smith, D. Thomas, B. Wansink, D. Allison and S. Heysmfield (in Press). Weighing the evidence of common beliefs in obesity research Crit Rev Food Sci Nutr. PMID: 24950157. Demerath, E. and D. Fields (2014). Body composition assessment in infants. Am J Hum Biol 26:291-304. PMID:24424686. Santos, D., A. Silva, C. Matias, J. Magalhaes, D. Fields, C. Minderico, U. Ekelund and L. Sardinah (2014). Validity of a combined heart rate and motion sensor for the measurements of free-living energy expenditure in very active individuals. J Sci Med Sport 17:387-93. PMID: 24184093. Fields, D, Gunatilake, R, Kalaitzoglou, E, Air Displacement Plethysmography: Cradle to Grave (NCP-2014-10-227). Nutrition in Clinical Practice. In Press. Gardner AW, Parker DE, Montgomery PS, Blevins SM, Teague A, Casanegra AI. Monitored daily ambulatory activity, inflammation, and oxidative stress in patients with claudication. Angiology 2014;65:491-496. PMID:23695338. PMCID:PMC3841224. Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Esponda OL, Ungvari Z, Csiszar A, Sonntag WE. Impaired vascular endothelial growth factor-A and inflammation in subjects with peripheral artery disease. Angiology 2014;65:683-690. PMID:24006146. PMCID:PMC4043949.
PUBLICATIONS
Rodrigues LBCC, Forjaz CLM, Lima AHRA, Miranda AS, Rodrigues SLC, Cardoso Jr, CG, Filho DS, Monteiro MF; Gomes SL, Gardner AW, Prado WL, Ritti-Dias RM. A single bout of resistance exercise does not modify cardiovascular responses during daily activities in patients with peripheral artery disease. Blood Pressure Monitoring 2014;19:64-71. PMID:24407028. PMCID:PMC3984917. Gardner AW, Parker DE, Montgomery PS, Blevins SM. Diabetic women are poor responders to exercise rehabilitation in the treatment of claudication. J Vasc Surg 2014;59:1036 -1043. PMID:24246541. PMCID:PMC3966945. Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Ungvari Z, Csiszar A, Sonntag WE. Gender and racial differences in endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease. J Vasc Surg. In press. PMID:24703977. PMCID:PMC4185015. Barbosa JPAS, Farah BQ, Chehuen MR, Cucato GG, FariasJunior JC, Wolosker N, Forjaz CLM, Gardner AW, Ritti-Dias RM. Barriers to physical activity in patients with intermittent claudication. Int J Behavioral Med. In press. PMID:24715636. Mauer K, Gardner AW, Dasari TW, Stoner JA, Blevins SM, Montgomery PS, Saucedo JF, Exaire JE. Clot Strength is Negatively Associated with Ambulatory Function in Patients with Peripheral Artery Disease and Intermittent Claudication. Angiology. In press. PMID:24778425. Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Ungvari Z, Csiszar A, Sonntag WE. Greater endothelial apoptosis and oxidative stress in patients with peripheral artery disease. Int J Vasc Med 2014;2014:160534. PMID:24963409. PMCID:PMC4054861. Gardner AW. Peripheral circulation of veterans and nonveterans with peripheral artery disease and claudication. Ann Gerontol Geriatr Res 2014;1:1003. Farah BQ, Ritti-Dias RM, Cucato GC, Menêses AL, Gardner AW. Clinical predictors of ventilatory threshold achievement in claudicants. Med Sci Sports Exerc. In press. (PMID:25003779)
Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Ungvari Z, Csiszar A, Sonntag WE. Endothelial cell inflammation and antioxidant capacity are associated with exercise performance and microcirculation in patients with peripheral artery disease. Angiology. In press. Tsutsui Y, Johnson JM, Demeler B, Kinter M, and Hays FA (2014) “Human p52Shc phosphorylation by c-Src suggests its active role in signaling cascade regulation”. J. Biol. Chem. Pending review. Boswell-Casteel RC and Hays FA (2014) “1.9 Å Resolution X-ray Crystal Structure of the Human HSPA8 (Hsc70) Nucleotide Binding Domain”. Acta Crystallogr. F Struct. Biol. Commun. Pending review. Boswell-Casteel RC, Johnson JM, Duggan KD, Tsutsui Y, and Hays FA (2014) “Overproduction and biophysical characterization of human HSP70 proteins.” Protein Expr. and Purif. Sep 27 S1046-5928. Boswell-Casteel RC, Johnson JM, Duggan KD, Roe-Zurz Z, Schmitz H, Burleson C, and Hays FA (2014) “FUN26 (function unknown now 26) protein from Saccharomyces cerevisiae is a broad selectivity, high-affinity, nucleoside and nucleobase transporter”. J. Biol. Chem. Aug 29; 289(35):24440-51. Tsutsui, Y. and Hays, F. A. (2014) Human p52shc Conformational Bias and Localization in C-SRC Activation. Biophys. J., 106(2):466a-467a (Poster presented by Dr. Tsutsui) Matsuzaki, S. and Humphries, K.M. Selective inhibition of deactivated complex I by biguanides. Submitted to Biochemistry. Bastian, A., Thorpe, J.E., Disch, B.C., Bailey-Downs, L.C., Gangjee, A., Ziware, N., Henthorn, J., Humphries, K.M., Vadvalkar, S.V., Inhat, M.A. A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial associated necrosis in breast cancer. Submitted to Journal of Pharmacology and Experimental Therapeutics. Lane, R.S., Humphries, K.M., Griffin, T.M. Mitochondrial Respiration and Redox Coupling in Articular Chondrocytes. In revision for Arthritis Research & Therapy.
Gardner AW, Parker DE, Montgomery PS, Blevins SM. Step monitored home exercise improves ambulation, vascular function, and inflammation in symptomatic patients with peripheral artery disease: A randomized controlled trial. J Am Heart Assoc 2014;3:e001107. (PMID:25237048).
Karamichos D, Funderburgh ML, Hutcheon AE, Zieske JD, Du Y, Wu J, Funderburgh JL. A role for topographic cues in the organization of collagenous matrix by corneal fibroblasts and stem cells. PLoS One. 2014 Jan 21;9(1):e86260.
Gardner AW. Impaired peripheral circulation in veterans with claudication is associated with smoking. Angiology Open Access 2014;3:1000132.
Karamichos D, Hutcheon AE, Rich CB, Trinkaus-Randall V, Asara JM, Zieske JD. In vitro model suggests oxidative stress involved in keratoconus disease. Sci Rep. 2014 Apr 9;4:4608.
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PUBLICATIONS (continued)
Karamichos D, Hutcheon AE, Zieske JD.Reversal of fibrosis by TGF-β3 in a 3D in vitro model. Exp Eye Res. 2014 May 4. pii: S0014-4835(14)00116-X. doi: 10.1016/j.exer.2014.04.020.
L. C. Kasi Viswanath, L. D. Shirtcliff, S. Krishnan, and K. D. Berlin, SubPc-ZnPorphyrin conjugates-Synthesis, characterization and properties, Dyes and Pigments. In Press.
Karamichos D. Keratoconus: In vitro and in vivo. (2014) J Ophth Volume 1, Issue 1: 002.
R. Nerimetla, C. Walgama, R. Ramanathan, and S. Krishnan, Correlating the Electrochemical Kinetics of Myoglobin-films to pH Dependent Meat Color, Electroanalysis, 2014, 26, 675-678.
Karamichos, D.; Hjortdal, J. Keratoconus: Tissue Engineering and Biomaterials. J. Funct. Biomater. 2014, 5, 111-134. In Review. Priyadarsini S, Sarker-Nag A, Allegood J, Chalfant C, Karamichos D. Description of the Sphingolipid Content and Subspecies in the Diabetic Cornea. Curr Eye Res. 2014 Nov 26:1-7. Griffith, G. L., Kasus-Jacobi, A., Lerner, M. R., Pereira, H. A. Corneal Wound Healing, a Newly Identified Function of CAP37, Is Mediated by Protein Kinase C Delta (PKCdelta). Invest Ophthalmol Vis Sci. 2014 Jul 15;55(8):4886-95. PMCID: PMC4126793. Kasus-Jacobi A., Noor-Mohammadi S., Griffith GL, Hinsley H, Mathias L, Pereira HA. A multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound-healing properties. J Leukoc Biol. 2014 Nov 20. Epub ahead of print. Li H, Scherlag BJ, Kem DC, Benbrook A, Shen X, Cunningham MW, Lazzara R, Aston CE, Yu X. Inducible cardiac arrhythmias caused by enhanced b1-adrenergic autoantibody expression in the rabbit. Am J Physiol Heart Circ Physiol 2014;306(3):H422-428. PMCID: PMC3920144. Li H, Yu X, Liles C, Khan M, Vanderlinde-Wood M, Galloway A, Zillner C, Benbrook A, Reim, S, Collier D, Hill MA, Raj SR, Okamoto LE, Cunningham MW, Aston CE, Kem DC. Autoimmune basis for postural tachycardia syndrome. J Am Heart Assoc 2014;3(1):e000755. PMCID: PMC3959717 Li H, Scherlag BJ, Kem DC, Zillner C, Male S, Thirunavukkarasu S, Shen X, Benbrook A, Pitha JV, Lazzara R, Yu X. The propensity for inducing atrial fibrillation: a comparative study in old versus young rabbits. J Aging Res 2014;2014:684918. PMCID: PMC3955625.
L. C. Kasi Viswanath, L. D. Shirtcliff, S. Krishnan, N. V. Handa, and K. D. Berlin, Synthesis, photophysical and electrochemical properties of bay-axial perylene diimide– subphthalocyanine dyads, Tetrahedron Lett. 2014, 55, 41994202. Page 3 of 6. V. Singh and S. Krishnan, Electrochemical Mass Sensor for Diagnosing Diabetes in Human Serum, Analyst, 2014, 139, 724 – 728. C. Walgama, S. Krishnan, Tuning the electrocatalytic efficiency of heme-protein films by controlled immobilization on pyrene-functionalized nanostructure electrodes, J. Electrochem. Soc., 2014, 161, H1-H6. Kurien BT, Fesmire M, Scofield RH. Anti-oxidized LDL/ anti-phospholipid antibodies in lupus subsets and induction of these antibodies in Ro 60/Ro60 peptide immunized animal model of lupus. Under review at Lupus. Kurien BT, Scofield RH. SDS-PAGE to immunodetection in one hour. Methods Mol Biol. Accepted. Kurien BT, Scofield RH. Fingerprinting on nitrocellulose and PVDF. Methods Mol Biol. Accepted. Kurien BT, Towbin, H. From Little Helpers to Automation. Methods Mol Biol. Accepted. Maier-Moore* JS, Kurien BT*, D’Souza A, Bockus L, Asfa S, Dorri Y, Hubbell S, Yeliosof O, Obeso D, Schoeb TR, Jonsson R, Scofield RH. Passive transfer of antibodies to the linear epitope 60 kD Ro 273-289 induces features of Sjögren’s syndrome in naïve mice. Clin Exp Immunol. 2014 Nov 4. doi: 10.1111/cei.12480. Epub ahead of print. *both authors contributed equally
Kem DC, Li H, Velarde-Miranda C, Liles C, VanderlindeWood M, Galloway A, Khan M, Zillner C, Benbrook A, Rao V, Gomez-Sanchez CE, Cunningham MW, Yu X. Autoimmune mechanisms activating the angiotensin AT1 receptor in ‘primary’ aldosteronism. J Clin Endocrinol Metab 2014;99(5):1790-1797. PMCID: PMC4010696.
Maier-Moore JS, Koelsch KA, Smith K, Lessard CJ, Radfar L, Lewis D, Kurien BT, Wolska N, Deshmukh U, Rasmussen A, Sivils KL, James JA, Farris AD, Scofield RH. Antibodysecreting cell specificity in labial salivary glands reflects clinical presentation and serology in sjögren’s syndrome patients. Arth Rheumatol 2014 Sep 8. doi: 10.1002/art.38872. [Epub ahead of print]
Li H, Scherlag BJ, Kem DC, Benbrook A, Zhang L, Huang B, Cunningham MW, Lazzara R, Yu X. Atrial tachyarrhythmias induced by the combined effects of b1/2-adrenergic autoantibodies and thyroid hormone in the rabbit. J Cardiovasc Transl Res 2014;7(6):581-589. PMID: 24903978.
M. A. de Laat, K.J. Gruntmeir, C. C. Pollitt, C. M. McGowan, M. N. Sillence and V.A. Lacombe. Hyperinsulinaemia negatively regulates myocardial TLR4 expression. Frontiers-endocrinology, 5:120, e1-8, 2014.
PUBLICATIONS
Fu S., Zhu M., Wang Y. Le Y. (2014). Efficient induction of productive Cre-mediated recombination in RPE. (Invited Research Article) Mol Vis 20:480-487 http://www.molvis.org/ molvis/v20/480 Dong S., Liu. Y.; Zhu, M., Xu, X., Le, Y. (2014) Simplified system to investigate alteration of retinal neurons in diabetes. Adv Exp Med Biol. 801:139-43. (doi: 10.1007/978-1-4614-32098_18). PMID:24664691. Ramamurthy V., Jolicoeur C., Koutroumbas D., Mühlhans J., Le Y., Hauswirth, W.W., Gießl A., Cayouette M. (2014) Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia, J. Neurosci. (2014) 34:13976 –13987.
Harold Hamm greets attendees at our Fall Open House, Oct. 2014 M. A. de Laat, C. K. Clement, C. C. Pollitt, C. M. McGowan, M. N. Sillence and V.A. Lacombe. Impact of prolonged Hyperinsulinaemia on the Regulation of Glucose Transport in the Equine muscle and digital lamellae. Equine Veterinary Journal, [Epub ahead of print], 2014. de Laat MA, Clement CK, McGowan CM, Sillence MN, Pollitt CC, Lacombe VA. Toll-like receptor and pro-inflammatory cytokine expression during prolonged hyperinsulinaemia. Vet Immunol Immunopathol. 157(1-2):78-86, 2014. Lacombe VA. Expression and Regulation of Facilitative Glucose Transporters in Equine Insulin-Sensitive Tissue: From Physiology to Pathology. ISRN Veterinary Science. 2014:1-15, 2014. Lacombe VA, Mayes M, Mosseri S, Reed SM, Ou TH. Distribution and predictive factors of seizure types in 104 cases. Equine Veterinary Journal. 46(4):441-5, 2014. Stevens RB, Foster KW, Miles CD, Lane JT, Kalili AC, Florescu DF, Sandoz JP, Rigley TH, Nielsen KJ, Skorupa JY, Kellogg AM, Malik T, Wrenshall LE. A Randomized 2x2 Factorial Trial, Part 1: Single-Dose Rabbit Antithymoctye Globulin Induction May Improve Renal Transplantation Outcomes. Transplantation. 2014 July 3. Epub ahead of print. PMID: 25083614. Lane, JT. The role of retinoids in the induction of nerve growth factor; a potential treatment for diabetic neuropathy. Transl Res. 2014 Sep; 164(3): 193-5 doi: 10.1016/j. trsl.2014.06.001 Epub 2014 Jun 13. PMID: 24995388.
Mao H, Seo SJ, Biswal MR, Li H, Conners M, Nandyala A, Jones K, charffetter- Kochanek K., Le Y, Lewin AS. (2014) Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration. Invest. Ophthalmol. Vis. Sci. 55:4613-27. (doi: 10.1167/iovs.14-14633). Fu S., Zhu M., Ash J.D., Wang Y. Le Y. (2014) Investigating the role of retinal Müller cells with approaches in genetics and cell biology., Adv Exp Med Biol. 801:401-5. (doi: 10.1007/978-14614-3209-8_51) PMID: 24664724. Zhou, K.K., Benyajati, S., Le, Y., Cheng, R., Wenbo Zhang, W. and Ma. J-x. (2014) Interruption of Wnt signaling in Müller cells ameliorates ischemia-induced retinal neovascularization. PlosOne, In press. Lee SM, Yang Yang, Richard B. Mailman. (2014) Dopamine D1 receptor signaling: Does GαQ-phospholipase C actually play a role? Journal of Pharmacology and Experimental Therapeutics 351(1):9-17. This article was selected for cover illustration of JPET October 2014. Lee SM, Andrew Kant, Daniel Blake, Vishakantha Murthy, Kevin Boyd, Steven J. Wyrick, Richard B. Mailman. (2014) SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase C. Neuropharmacology 86:145-54. McBride, J., Alicia Jenkins, A.J., Liu, X., Zhang, B., Lee, L., Berry, W.L., Janknecht, R., Griffin, C., Aston, C.E., Lyons, T., Tomasek, J.J. and Ma, J-x. (2014) Elevated Circulation Levels of an Anti-angiogenic SERPIN Impairs Wound Healing through Suppression of Wnt Signaling. J. Invest. Dermatol., 134:1725-34. PMID:24463424. Isayama, T., Chen, Y., Kono, M., Fabre, E., Slavski, M., DeGrid, W.J., Ma, J-x., Crouch, R.K. and Makino, C.L. (2014) Coexpression of three opsins in cone photoreceptors of the salamander Ambystoma tigrinum. J. Comparative Neurol., 522:2249-65. PMCID:PMC3997598.
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PUBLICATIONS (continued)
Qiu, F., He, J., Zhou, Y., Bai, X., Wu, G., Wang, X., Liu, Z., Chen, Y., Ma, J-x. and Liu, Z. (2014) Plasma and vitreous fluid levels of Dickkopf-1 in patients with diabetic retinopathy. Eye 28:402-409. PMCID:PMC3983621.
Sampaio Brandão GM, Sobreira ML, Malgor RD, Rollo HA. Recanalization rates after acute deep vein thrombosis: A single-center experience using a newly proposed vein diameter variation index. Ann Vasc Surg. 2014 Oct;28(7):1751-60.
Wang, Z., Moran, E., Ding, L., Cheng, R., Xu, X., and Ma, J-x. (2014) PPARα Regulates Mobilization and Homing of Endothelial Progenitor Cells through the HIF-1/SDF1 Pathway. Invest. Ophthalmol. Vis. Sci. 55(6):3820-32. PMCID:PMC4064689.
Malgor RD, Bilfinger TV. Left Subclavian Artery Occlusion during Blunt Thoracic Aortic Injury Endovascular Repair. Ann Thorac Surg. 2014 Jul;98(1):386.
Zhou, T., Lin, Z. Chen, L., Zong, Z., Zhu, C., Pan, F., Ma, J-x., Liu, Z. and Zhou, Y. (2014) Serine Proteinase Inhibitor SERPINA3K Suppresses Corneal Neovascularization via Inhibiting Wnt Signaling and VEGF. Invest. Ophthalmol. Vis. Sci. In press. Rajala, A., Wang, Y., Zhu, Y., Ranjo-Bishop, M., Ma, J-x, Mao, C. and Rajala, RVS. (2014) Nanoparticle-Assisted Targeted Delivery of Eye-Specific Genes to Eyes Significantly Improves the Vision of Blind Mice In Vivo. Nano Lett. 14(9):5257-63. PMCID:PMC4160266. Gong, G., Shaopeng Qiu, S., Li, S., Ma, Y., Chen, M., Yao, Y., Chen, D., Feng, J., Cai, W., Ma, J., Yang, X., Gao, G., Yang, Z. (2014) Proapoptotic PEDF functional peptides inhibit prostate tumor growth – A mechanistic study. Biochem. Pharmacol. 92,425-437.
Labropoulos N, Tzogias L, Malgor RD, Antoniou G, Giannoukas AD. Phlebosclerosis in lower extremities veins. Phlebology. 2014 Apr;29(3):186-90. Chan AY, Mann SN, Chen H, Stone DU, Carr DJ, Mandal NA. Sphingolipids in ocular inflammation. Adv Exp Med Biol. 2014;801:623-9. Marchette LD, Sherry DM, Brush RS, Chan M, Wen Y, Wang J, Ash JD, Anderson RE, Mandal NA. Very long chain polyunsaturated fatty acids and rod cell structure and function. Adv Exp Med Biol. 2014;801:637-45. Mandal NA, Tran JT, Zheng L, Wilkerson JL, Brush RS, McRae J, Agbaga MP, Zhang K, Petrukhin K, Ayyagari R, Anderson RE. In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4. Invest Ophthalmol Vis Sci. 2014 Apr 25;55(4):2705-13.
Wei, Q., Zhang, F., Richardson, M.M., Roy, N.H., Rodgers, W., Liu, Y., Fu, C., Ding, Y., Zhao, W., Huang, C., Chen, Y., Sun, Y., Ding, L., Hu, Y., Ma, J-x., Boulton, M.E., Pasula, S., Wren, J.D., Huang, X., Tanaka, S., Thali, M., Hämmerling, G.J., Zhang, X.A. (2014) CD82 Restrains Angiogenesis by Altering Lipid Raft Clustering and CD44 Trafficking in Endothelial Cells. Circulation. In press. PMID:25149363. Zhu, C., Pan, F., Ge, L., Zhou, J., Chen, L., Zhou, T., Zong, R., Xiao, X., Dong, N., Yang, M., Ma, J-x., Liu, Z., Zhou, Y. (2014) SERPINA3K Plays Antioxidant Roles in Cultured Pterygial Epithelial Cells through Regulating ROS System. PLoS One. 9(10):e108859. PMCID:PMC4189792 Qi, W., Yang, C., Dai, Z., Che, D., Feng, J., Mao, Y., Cheng, R., Wang, Z., He, X., Zhou, T., Gu, X., Yan, L., Yang, X., Ma, J-x., Gao, G. (2014) High Levels of Pigment Epithelium-derived Factor in Diabetes Impair Wound Healing through Suppression of Wnt Signaling. Diabetes. In press. Malgor RD, Bilfinger TV, McCormack J, Tassiopoulos AK. Outcomes of Blunt Thoracic Aortic Injury in Adolescents. Ann Vasc Surg. 2014. In press. Malgor RD, Margolis J, Montecalvo J, Shahidul I, Hines G. Long Term Evaluation of Endoscopically Harvested Saphenous Vein for Lower Extremity Bypass. Acta Chir Belg. In press.
Jennifer Chadwick of Harold Hamm-Children’s discusses her role in the MOVE study (see pp. 14-15)
PUBLICATIONS
Chen H, Chan AY, Stone DU, Mandal NA. Beyond the cherry-red spot: Ocular manifestations of sphingolipidmediated neurodegenerative and inflammatory disorders. Surv Ophthalmol. 2014 Jan-Feb;59(1):64-76. Masser DR, VanGuilder Starkey HD, Bixler GV, Holtry W, Bronson SK, Freeman WM. Insulin treatment normalizes retinal neuroinflammation but not synapse loss in diabetic rats. Exp Eye Res 125, 95-106, PMID24931083 (2014). Masser DR, Bixler GV, Brucklacher RM, Yan H, Giles CB, Wren JD, Sonntag WE, Freeman WM. Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and non-neurodegenerative cognitive decline. J Gerontol A Biol Sci Med Sci 69, 1311-1324, PMID24994846 (2014).
Kandice Tessneer, Robert M. Jackson, Beth A. Griesel, Ann Louise Olson. Rab5 activity regulates GLUT4 sorting into insulin-responsive and non-insulin-responsive endosomal compartments: A potential mechanism for development of insulin resistance. Endocrinology, 155:3315-3328, 2014. Owora AH, Risch E, Nandyal R, Bonner B, Chaffin, M. (2014) Medical surveillance and child maltreatment incidence reporting among NICU graduates. Journal of Perinatal and Neonatal Nursing. In Press. Risch E, Owora AH, Nandyal R, Bonner B, Chaffin, M. (2014) Risk factors for child maltreatment among infants discharged from a Neonatal Intensive Care Unit: A sibling comparison. Child Maltreatment. In Press.
Masser DR, Stanford DR, Freeman WM. Targeted DNA methylation analysis by next generation sequencing. JoVE. In press.
Beasley L, Silovsky JF, Owora AH, Burris L, Hecht D. (2014) Mixed-methods feasibility study on the cultural adaptation of a child abuse prevention model. Child Abuse and Neglect. In Press.
Mangold CA, Masser DR, Bixler GV, Pisupati A, Giles CB, Wren JD, Ford MM, Sonntag WE, Freeman WM. Age-related Sexually Dimorphic Regulation of the Major Histocompatibility Complex Class I in the CNS. Aging Cell. Submitted.
Balachova T, Bonner B, Bard D, Chaffin M, Isurina G, Owora AH. (2014) Women’s receptivity to Fetal Alcohol Spectrum Disorders prevention approaches: A case study of two regions in Russia. International Journal of Alcohol and Drug Research 2014; 3(1), 5-15.
Kawashima, Y., Kodera, Y., Singh, A., Matsumoto, M., and Matsumoto, H. 2014. Efficient extraction of proteins from formalin-fixed paraffin-embedded tissues requires higher concentration of tris(hydroxymethyl)aminomethane. Clinical Proteomics 11: 4. PMID: 24484752 [PubMed] PMCID: PMC3922997.
Kirkpatrick AC, Tafur AJ, Vincent AS, Dale GL, Prodan CI. Coated-platelets improve prediction of stroke and TIA in asymptomatic internal carotid artery stenosis. Stroke, 2014; 45(10):2995-3001.
Cai, A., Hutchison, E., Hudson, J., Kawashima, Y., Komori, N., Singh, A., Brush, R.S., Anderson, R.E., Sonntag, W.E., Matsumoto, H., and Griffin, T.M. 2014. Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce spontaneous knee osteoarthritis in aging mice. Osteoarthritis and Cartilage. In press. Myers DA, Singleton K, Hyatt K, Mlynarczyk M, Kaushal K, Ducsay DA. 2014. Long term gestational hypoxia modulates expression of key genes governing mitochondrial function and biogenesis in the perirenal adipose of the late gestation sheep fetus. Reprod. Sciences. ePub ahead of print PMID: 25504105. Fukuyo, Y., Nakamura, T., Bubenshchikova, E., Powell, R., Tsuji, T., Janknecht, R., & Obara, T. (2014) Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros, Molecular Medical Report, 9 (2), 457-465. PMID: PMC24337247
Kirkpatrick AC, Vincent AS, Guthery L, Prodan CI. Cognitive impairment is associated with medication nonadherence in asymptomatic carotid stenosis. The American Journal of Medicine. In press. Kirkpatrick AC, Vincent AS, Dale GL, Prodan CI. Cognitive impairment is associated with elevated coated-platelets in patients with carotid atherosclerosis. Journal of the American Geriatrics Society, 2014; 62(7):1393-1395. Prodan CI, Stoner JA, Gordon DL, Dale GL. Cerebral microbleeds in nonlacunar brain infarction are associated with lower coated-platelet levels. J Stroke Cerebrovascular Diseases, 2014; 23(5):e325-e330. Prodan CI. Response to Letter to the Editor from Dr. Dale Ding: Molecular insights into aneurysmal subarachnoid hemorrhage and cerebral vasospasm from analysis of coatedplatelets. Journal of the Neurological Sciences, 2014;338:237. Rajala RVS, Rajala A, Morris AJ and Anderson RE (2014) Phosphoinositides: Minor lipids make a major impact on photoreceptor cell functions. Scientific Reports, 4: 5463.
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PUBLICATIONS (continued)
Woodruff ML, Rajala A, Fain GL and Rajala RVS (2014) Modulation of mouse rod photoreceptor responses by Grb14. Journal of Biological Chemistry, 289: 358-364. Rajala RVS, Kanan Y and Anderson RE (2014) Photoreceptor neuroprotection: Regulation of Akt activation through serine/threonine phosphatases, PHLPP and PHLPPL. Advances in Experimental Biology and Medicine. In press. W.C. Fok, A. Bokov, J. Gelfond, Z. Yu, Y. Zhang, M. Doderer, Y. Chen, M. Javors, W.H. Wood, Y. Zhang, K.G. Becker, A. Richardson, and V.I. Pérez. Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver. Aging Cell, 13:311-319, 2014. W.C. Fok, Y. Chen, A. Bokov, Y. Zhang, A.B. Salmon, V. Diaz, M. Javors, W.H. Wood, Y. Zhang, K.G. Becker, V.I. Pérez, and A. Richardson. Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS One 9: e83988, 2014. K. Darvin, A. Randolph, S. Ovalles, D. Halade, L. Breeding, A. Richardson, and S.E. Espinoza. Plasma protein biomarkers of the geriatric syndrome of frailty. J Gerontol A Biol Sci Med Sci., 69:182-6, 2014. G. K. Sakellariou, C. S. Davis, Y. Shi, M. V. Ivannikov, Y. Zhang, A. Vasilaki, G. T. Macleod, A. Richardson, H. Van Remmen, M. J. Jackson, A. McArdle, and S. V. Brooks. Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD knockout mice. FASEB J., 28:1666-81, 2014. A. Richardson and E. Schadt. “The role of macromolecular damage in aging and age-related disease.” J Gerontol A Biol Sci Med Sci., 69:S28-32, 2014. W.C. Fok, C. Livi, A. Bokov, Y. Chen, A. Richardson, and V.I Pérez. Short-term rapamycin treatment in mice have few effects on the transcriptome of white adipose tissue compared to dietary restriction. Mech. Ageing Dev., 140: 23-29, 2014. B.K. Kennedy, S.L. Berger, A. Brunet A, J. CampisiJ, A.M. Cuervo, E.S. Epel, C. Franceschi, G.J. Lithgow, R.E. Morimoto, J.E. Pessin, T.A. Rando, A. Richardson, E.E. Schadt, T. WyssCoray, and F. Sierra. Geroscience: linking aging to chronic disease. Cell, 159: 709-713, 2014. Y. Liu, V. Diaz, E. Fernandez, R. Strong, L.Y., J.A. Baur, D.W. Lamming, A. Richardson, A.B. Salmon. Rapamycin-induced metabolic defects are transient in both lean and obese mice. Aging, 6:742-754, 2014. A. Richardson, V. Galvan, A.L. Lin, and S. Oddo. “How longevity research can lead to therapies for Alzheimer’s disease: the rapamycin story.” Exp. Geront. In press.
S. Tardif, C. Ross, P. Bergman, E. Fernandez, M. Javors, A. Salmon, J. Spross, R. Strong, and A. Richardson. “Testing efficacy of administration of the anti-aging drug rapamycin in a non-human primate, the common marmoset.” J Gerontol A Biol Sci Med Sci. In press. Madrigal, D., Minkler, M., Salvatore, A.L., Rosas, L.G., Castillas, G., Eskenazi, B. (In press). Using photovoice with Latino youth in an agricultural area to address environmental health and justice. Progress in Community Health Partnerships. Patil, S., Arnold, B., Salvatore, A.L., Colford, J., Briceno, B., Gertler, P. (2014). A Cluster Randomized Controlled Trial of India’s Total Sanitation Campaign in Rural Madhya Pradesh. PLoS Medicine. Aug 26;11(8):e1001709. doi: 10.1371/journal. pmed.1001709. Minkler, M. Salvatore, A.L., Chang, C., Lee, P.T., Liu, S.S., Tom, A.T., Gaydos, M.E., Bhatia, R. (2014). Wage Theft as a Neglected Public Health Problem: Findings from a Community–Based Participatory Research Study with Chinese Immigrant Workers. American Journal of Public Health. 2014 Jun;104(6):1010-20. doi: 10.2105/AJPH.2013.301813. Epub 2014 Apr 17. PMID: 24825200. Saxena R, Bjonnes A, Prescott J, Dib P, Natt P, Lane J, Lerner M, Cooper JA, Ye, Y, Ka Wah Li KW, Maubaret CG, Codd V, Brackett D, Mirabello L, Kraft P, Dinney CP, Stowell D, Marvin P, Ralhan S, Wander GS, Mehra NK, Salpea KD, Gu J, Wu X, Mangino M, Hunter DJ, De Vivo I, Humphries SE, Samani NJ, Spector TD, Savage SA, Sanghera DK (2014). A genomewide association study identifies variants in Casein Kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort. Circulation Cardiovascular Genetics. Epub ahead of print. PMID:24795349. McCarty CA, Huggins W, Aiello A, Bilder R, Jernigan TL, Sanghera DK, Strauman TJ, Zeng Y, Ramos EM, Junkins HA; for the PhenX RISING network (2014). PhenX RISING: real world implementation and sharing of PhenX measures. BMC Medical Genomics, 7:16 Epub ahead of print doi: 10.1186/17558794-7-16. PMID: 24650325. Subramanian A, Dib P, WanderGS, Ralhan S, Sanghera DK (2014). The PPAR γ (P12A) locus-associated diabetes risk is modulated by central obesity in Punjabi Sikhs. Journal of Molecular Genetic Medicine Epub ahead of print doi. org/10.4172/1747-0862.S1-017.
PUBLICATIONS
Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D…….Sanghera DK...) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium & Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium (2014). Genome-wide trans-ancestry metaanalysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics EPub: doi:10.1038/ ng.2897. PMID:24509480. Scifres CM, Feghali M, Althouse A, Caritis SN, Catov J. Effects of Excess Gestational Weight Gain on Pregnancy Outcomes in Women with Type 1 Diabetes. Obstetrics and Gynecology 2014;123(6):1295-1302. Scifres CM, Abebe KZ, Jones KA, Comer DM, Costacou T, Freiberg MS, Simhan HN, Day NL, Davis EM. Gestational Diabetes Diagnostic Methods (GD2M) Pilot Randomized Trial. Maternal Child Health Journal, 2014. Epub ahead of print. Stamilio DM, Scifres CM. Extreme Obesity and PostCesarean Maternal Complications. Accepted for publication, Obstetrics and Gynecology. Makkar A, Mishima T, Chang G, Scifres C, Sadovsky Y. Fatty Acid Binding Protein 4 is Expressed in the Mouse Placental Labyrinth, Yet is Dispensable for Placental Triglyceride Accumulation and Fetal Growth. Accepted for publication, Placenta. Guthridge JM, Lu, R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langfield CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Villa LM, Kimberly RP, Freedman BI, Stevens AM, Boackle SA, Criswell LA, Vyse TJ, Behrens, Jacob CO, Alarcón-Riquelme ME on behalf of the BIOLUPUS Network, Sivils KL, Bae S-C, Cho SK, Bang SY, Kim LL, Choi C-B, Shen N, Qian X, Tsao BP, Harley JB, Scofield RH, Webb CF, Wakeland EK, James JA, Nath SK, Graham RR, Gaffney PM. Two functional lupus associated BLK promoter variants control cell-type and developmental stage specific transcription. Am J Hum Genet 94:586-98; 2014 Apr. PMCID:PMC3980411. Ritterhouse LL, Lu R, Shah HB, Robertson JM, Fife DA, Maecker HT, Du H, Fathman CG, Chakravarty EF, Scofield RH, Kamen DL, Guthridge JM, James JA. Vitamin D deficiency in a multiethnic healthy control cohort and altered immune response in vitamin d deficient European-American healthy controls. PLoS One 9:e94500 2014 Apr. PMCID:PMC3984168. Scofield RH. Rheumatic disease and the microbiome. Int J Rheum Dis. In press.
Clark EG, Greg Knoll G, Bugeja A, Kevin D. Burns KD, Scofield RH. Lupus After Kidney Donation: A Case Report with Implications for the Evaluation of Potential Donors with a Family history of Lupus. Submitted. Ding, L., Cheng, R., Hu, Y., Takahashi, Y., Jenkins, A.J., Keech, A.C., Humphries, K.M., Gu, X., Elliott, M.H., Xia, X. and Ma, J-x. (2014) PPARα Protects Capillary Pericytes in the Retina. Am. J. Pathol. 184(10):2709-20. PMCID:PMC4188867. Takahashi, Y., Moiseyev, G. and Ma, J-x. (2014) Identification of Key Residues Determining Isomerohydrolase Activity of Human RPE65. J. Biol. Chem. 289(39):26743-51. PMCID: PMC4175317. Lee, K., Shin, Y., Cheng, R., Park, K., Hu, Y., McBride, J., He, X., Takahashi, Y. and Ma, J-x. (2014) Receptor heterodimerization as a novel mechanism for regulation of Wnt/β-catenin signaling. J. Cell Sci., 149302. PMID:25271056. Moran, E., Ding, L., Cheng, R., Chen, Q., Wang, Z., Moore, R., Takahashi, Y., and Ma, J-x. (2014) Protective and Antioxidant Effects of PPARα in the Ischemic Retina. Invest. Ophthalmol. Vis. Sci. 55(7):4568-76. PMCID:PMC4109406. Tryggestad JB and Willi SM. Complications and comorbidities of T2DM in adolescents: findings from the TODAY clinical trial. Journal of Diabetes and Its Complications. Accepted. Tryggestad JB, Wang JJ, Zhang SX, Thompson DM, Short KR. Elevated plasma pigment epithelium-derived factor in children with type 2 diabetes mellitus is attributable to obesity. Pediatr Diabetes. 2014. Epub 2014/10/09. Tryggestad JB, Short KR. Arterial Compliance in Obese Children: Impliacations for Cardiovascular Health. Exerc Sport Sci Rev. 2014;42(4):175-82. Epub 2014/07/26. Xing, J, Liu H, Yang H, Chen R, Chen YG and Xu J. Upregulation of unc-51-like kinase 1 by nitric oxide stabilizes SIRT1, independent of autophagy. PLoS ONE. 2014; 9(12):e116165. PMCID: PMC4277463. Liu H, Yu S, Zhang H and Xu J. Identification of nitric oxide as an endogenous inhibitor of 26S proteasomes in vascular endothelial cells. PLoS ONE. 2014; 9(5):e98486. PMCID: PMC4031199.
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LOCATIONS
OUR LOCATIONS Harold Hamm Diabetes Center 1000 North Lincoln Boulevard Oklahoma City, OK 73104 (405) 271-7000
Harold Hamm Diabetes Center – Children’s
Harold Hamm Diabetes Center – Tulsa
OU Children’s Physicians Building
OU-Tulsa Schusterman Center Clinic
1200 North Children's (aka Phillips) Avenue
4444 East 41st Street
Suite 4500
Tulsa, OK 74135
Oklahoma City, OK 73104
(918) 619-4803
(405) 271-3303
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80 2014 ANNUAL REPORT
University of Oklahoma Board of Regents Tom Clark, Chairman Jon R. Stuart, Vice Chairman A. Max Weitzenhoffer
2014 Annual Report EDITOR Katie Hoefling Harold Hamm Diabetes Center Administration
Clayton I. Bennett Kirk D. Humphreys Leslie J. Rainbolt-Forbes, MD
COPY EDITOR Andy Behrens Harold Hamm Diabetes Center Administration
Bill W. Burgess, Jr. University Administration David L. Boren, President M. Dewayne Andrews, MD, MACP
CREATIVE DESIGN Haley Fulco University of Oklahoma Printing Services
Executive Dean, College of Medicine
PHOTOGRAPHY Aaron Snow Photography Andy Behrens Thomas White
Harold Hamm Diabetes Center
This publication, printed by University Printing Services, is issued
Senior Vice President and Provost, Health Sciences Center
Executive Committee Blake T. Rambo, JD, MBA, Chief Operating Officer Chairman, Executive Committee Harold Hamm Diabetes Center
by the Harold Hamm Diabetes Center at the University of Oklahoma. 1,000 copies have been prepared and distributed at no cost to the taxpayers of the State of Oklahoma. The University of Oklahoma, in compliance with all applicable federal and state laws and regulations does not discriminate on the basis of race, color, national origin, sexual orientation, genetic information, sex, age, religion, disability, political beliefs, or
Kenneth C. Copeland, MD, Director Harold Hamm Diabetes Center-Children’s David H. Jelley, MD, Director Harold Hamm Diabetes Center-Tulsa James T. Lane, MD, Director Harold Hamm Diabetes Center Adult Clinical Programs
status as a veteran in any of its policies, practices, or procedures. This includes, but is not limited to: admissions, employment, financial aid, and educational services. For questions regarding discrimination, sexual assault, sexual misconduct, or sexual harassment, please contact the Office(s) of Institutional Equity as may be applicable: Norman campus at (405) 325-3546/3549, the Health Sciences Center at (405) 271-2110, or the OU-Tulsa Title IX Office at (918) 660-3107. Please see www.ou.edu/eoo.
HAROLDHAMM.ORG
Jian-xing Ma, Director Harold Hamm Diabetes Center Research Programs
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