Harold Hamm Diabetes Center 2015 Annual Report by Harold Hamm Diabetes Center

Harold Hamm Diabetes Center 2015 Annual Report

Ellie McClain with her family and Dr. Kenneth Copeland, Director of HHDC-Children's. What is known about caring for Ellie and other patients with diabetes continues to stem from the groundbreaking work of researchers and cinicians at Harold Hamm Diabetes Center, every day moving us one step closer to a world wihtout diabetes.

H A ROL D H A M M DI A BET E S CE N T E R

More than one in three Oklahomans have diabetes or pre-diabetes.

Imagine how different their lives would be and the billions of dollars in annual health care costs that would be saved if there were a cure for diabetes. The McClain family knows all too well the challenges

To make matters worse, the McClain family was in the

that living with diabetes brings. Every minute of

process of moving from Georgia to Oklahoma. "Looking

every day, they worry, knowing that without careful

back, however, our family now believes our move was

monitoring and without the right doses of insulin, their

divine intervention, because it led us to the team at

little girl’s life could be in jeopardy.

Harold Hamm Diabetes Center at the University of Oklahoma," Taina said.

Ellie McClain looks and acts like most other 11-year-olds, but looks in this case are deceiving. Ellie’s days are filled

Back in Georgia, Ellie and her famiy had been provided

with careful counting and complex calculations just

with basic survival skills when she was first diagnosed.

to keep her healthy. The family’s been living through

When she got to Oklahoma, the team at HHDC took

a crash course in diabetes management since her

what she and her family had learned and expanded upon

diagnosis in 2015.

it, giving the family new knowledge and tools, inlcduing a device worn by Ellie that continuously monitors

It started with a sudden and dramatic change in Ellie’s

her blood sugar levels and sounds the alert if they

appearance, weight, and well-being. Ellie was admitted

drop too low.

to the hospital hoping to find answers. The diagnosis was, as her mom had suspected and feared, type 1 diabetes.

Most importantly, the team at HHDC taught Ellie and her family to live with type 1 diabetes every day. That

“It tore my heart out when they said, ‘Yes Mom, you’re

empowerment, for Ellie, her family, and for everyone

right. She has type 1 diabetes.’ That’s the one time you

impacted by diabetes, is at the heart of Harold Hamm

don’t want to be right,” Tania McClain said. “You’re

Diabetes Center's mission.

completely unprepared and scared out of your mind. You just have no idea of what to do, how to do it, and when to do it,” she said.

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Did you know?

EVERY 19 SECONDS someone in the U.S. is diagnosed with diabetes

1 OUT OF 3

1 OUT OF 4

13 YEARS

will develop diabetes in

people with diabetes donâ&#x20AC;&#x2122;t even

Type 1 diabetes reduces life

their lifetime

know they have it

expectancy by up to 13 years

1.25 MILLION PEOPLE

RISK OF DEATH

$1 IN $10

are living with

is 50% higher for adults

healthcare dollars is spent

type 1 diabetes

with type 2 diabetes

treating diabetes

29.1 MILLION AMERICANS already have diabetes Adapted from: A Snapshot of Diabetes in the United States, Centers for Disease Control and Prevention, 2014; Diabetes in Oklahoma, Oklahoma State Department of Health, Chronic Disease Division, July 2014. National Diabetes Statistics Report, 2014; Diabetes by the Numbers, American Diabetes Association

H A ROL D H A M M DI A BET E S CE N T E R

1 OUT OF 3 Oklahomans has type 2 diabetes or is prediabetic

ADULT DIABETES DIAGNOSES

15,000 OKLAHOMA FAMILIES

are increasing at a faster rate

live daily with

in Oklahoma than in the U.S.

type 1 diabetes

4TH HIGHEST

2 OUT OF 3

Oklahomaâ&#x20AC;&#x2122;s national ranking for

Oklahomans are obese or overweight, and thus

deaths caused by diabetes

at severe risk for developing type 2 diabetes

A 5% reduction in the average body mass index of Oklahomans by 2030 would result in 110,000 fewer new diagnoses of T2D and save the state $3 billion

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Healthcare, simply defined, is medical treatment. But it’s much more than that. Healthcare is passionate, skilled professionals caring for their neighbors. It’s researchers making breakthroughs and discovering cures. OU Medicine is a cornerstone of our community, a source of reassurance, a symbol of hope. This is exemplified at Harold Hamm Diabetes Center at the University of Oklahoma, an OU Medicine comprehensive center of excellence. At the heart of the center’s mission is our unfaltering belief that now is the time to take action to reduce the devastating impact of diabetes. One in three Americans is expected to develop diabetes in their lifetime, and every 19 seconds a new person is diagnosed. Our family, friends, neighbors, and even ourselves are a part of this trend. We can no longer afford to ignore it. That sense of urgency has led Harold Hamm Diabetes Center to become one of the top comprehensive diabetes centers in the United States, leading the way to prevent, treat, and ultimately find a cure for diabetes and its complications. The center’s coalition of diabetes researchers is one of the most diverse and top-funded in the world today, yielding new discoveries that change the course of medicine. People in Oklahoma and the surrounding region have access to comprehensive diabetes care of unprecedented quality, enhanced by the center’s advances in clinical research and scientific discovery. By addressing perhaps one of the most significant root causes of type 2 diabetes, the center’s prevention and outreach programs have touched many people at risk, helping them avoid developing the disease altogether. The pages of this report contain but a few examples demonstrating the center’s many innovative efforts and its meaningful impact, inspiring hope that we will one day live free of diabetes. This report also shows that we’re not fighting the diabetes epidemic alone. Indeed, we join many individuals, institutions, and organizations that are working together through a common purpose. To each of you, we cannot express enough our appreciation for joining us in this shared goal. We look forward to the even greater impact that is sure to come from our continued partnership.

David L. Boren

Blake T. Rambo, J.D., M.B.A.

President

Chief Operating Officer

The University of Oklahoma

Harold Hamm Diabetes Center

H A ROL D H A M M DI A BET E S CE N T E R

Harold Hamm Diabetes Center

2015 Annual Report

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2015 Features and Highlights

Symposiums, Lectures, and Seminars

Community of Support

Financial Information

Members, Faculty, and Staff

Active Grants

Publications 66

Locations 76

H A ROL D H A M M DI A BET E S CE N T E R

2015

FEATURES

& Highlights

$425,000 in HHDC Grants Awarded to Members in 2015

Harold Hamm Diabetes Center has more than 125

MEMBERSHIP AWARDS COMMITTEE

members who represent a coalition of diabetes-focused professionals in diverse disciplines including researchers, clinicians and other healthcare professionals. The center’s members represent institutions across the state of Oklahoma, including all three OU campuses, Oklahoma State University, Oklahoma Medical Research Foundation, the Oklahoma State Department of Health, and others. This has contributed to HHDC serving as the focal point for addressing diabetes in Oklahoma, encouraging collaboration among its members in novel research, innovative translational activities that will ultimately bring new treatments and therapies to patients, and strategies to help people prevent diabetes. In 2015, the center awarded almost half a million dollars to its members through a variety of grant opportunities made possible by private philanthropy. Representing a unique public/private partnership, using donations to provide funding for such projects has led to significant new grant dollars being received by our members

Steven D. Chernausek, M.D., Chair OU College of Medicine Department of Pediatrics Robert “Gene” Anderson, M.D., Ph.D. Dean McGee Eye Institute OU Health Sciences Center Martina Jelley, M.D. OU-Tulsa School of Community Medicine Department of Internal Medicine Robert “Hal” Scofield M.D. OU College of Medicine Department of Internal Medicine Zhongjie Sun, M.D., Ph.D. OU College of Medicine Department of Physiology Luke I. Szweda, Ph.D. Oklahoma Medical Research Foundation

and brought into the state. As a result of HHDC's investments in its members and their work in diabetes research, treatments, and prevention, new, multimillion-

In addition, where traditional funding sources do not

dollar grants have been received from the National

exist, these awards have allowed our members to explore

Institutes of Health, the American Diabetes Association,

projects which show significant potential for finding

the American Heart Association, the Oklahoma Center

new ways to counteract diabetes. They also promote

for the Advancement of Science and Technology, and

collaboration with colleagues at other institutions and

many more.

fund members’ travel to professional society meetings to present the discoveries they have made.

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Director of Research Programs Dr. Jian-xing Ma (left) fosters the growth of HHDC research projects. Some investigations funded by HHDC member grants go on to earn multimillion-dollar investments from the National Institutes of Health and other major scientific organizations.

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The following HHDC Member projects were funded in 2015: SEED GRANTS To increase the amount, quality, and diversity of diabetes and related research by providing financial support to enable HHDC members to initiate a research project and generate sufficient data to be more competitive for new external funding SH3 domain binding kinase 1 (SBK1) is a novel regulator of hepatic gluconeogenesis Chi Bun Chan, Ph.D., Department of Physiology, OU College of Medicine Maternal Transmission of Dietary Sugars Through Breast Milk David Fields, Ph.D., Department of Pediatrics, OU College of Medicine Decreased expression of protein kinase inhibitor (PKI) in the diabetic heart Kenneth Humphries, Ph.D., Oklahoma Medical Research Foundation Mathematical Modeling of Podocytes in Diabetic Kidney Disease Ashlee Ford Versypt, Ph.D., Oklahoma State University

ENRICHMENT GRANTS To advance diabetes research, clinical care, and prevention by providing start-up funding to establish a new project or program, or supplemental funding to enhance an existing program or project The regulation of glucose transport in the atria: Impact during diabetes Veronique Lacombe, D.V.M., Ph.D., Oklahoma State University Creation of the Center for Diabetes in Pregnancy (CDP) Program Christina Scifres, M.D., Department of Obstetrics and Gynecology, OU College of Medicine Genetic determinants of serum metabolites and their relationship to diabetes Dharambir Sanghera, Ph.D., Department of Pediatrics, OU College of Medicine An Analysis of Type 1 Diabetes Sensor-Augmented Insulin Pump Therapy Data Nicholas Davis, Ph.D., OU-Tulsa School of Community Medicine

DREAM CONCEPT AWARD To support high-risk/high-reward research projects that demonstrate exceptional creativity and propose highly innovative approaches to major, contemporary challenges in diabetes Point of Care Screening for Pediatric Cardiovascular Health Piers Blackett, M.D. 6

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EQUIPMENT GRANT To strengthen or expand a research or clinical project or program through the purchase or upgrade of an item of laboratory or clinical equipment. Blue pippin instrumentation for genomic studies Willard Freeman, Ph.D., Departments of Geriatrics and Physiology, OU College of Medicine

TRAINING GRANTS To enhance the educational value of research and clinical training programs by providing trainees with financial resources to further projects conducted as part of their training program Critical interactions of peptide ligands with the amylin receptor toward improved pharmacotherapy for diabetes Sang Min Lee, Ph.D., Departments of Biochemistry and Molecular Biology, OU College of Medicine Quantification of retinal mtDNA damage with diabetes Dustin Masser, B.S., OUHSC, Department of Physiology, OU College of Medicine

TRAVEL STIPENDS To support the development or continuation of collaborative relationships at other research institutions, and the professional development and presentation of center memberâ&#x20AC;&#x2122;s work at professional meetings

Association of Genome Biology and Technology (AGBT) Conference Abstract Presentation: Rat genome-wide capture of gene regulatory regions and base-resolution quantitation of DNA methylation. David Stanford, Ph.D., Departments of Physiology, OU College of Medicine

Endocrine Society Conference Presentation: Data regarding changes in cord blood adipokines imposed by in utero exposure to maternal diabetes April Teague, M.S., Department of Pediatrics, OU College of Medicine

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A world without diabetes is a vision shared by us all. HAROLD HAMM INTERNATIONAL PRIZE for BIOMEDICAL RESEARCH in DIABETES To make that vision

“My hope in awarding this unprecedented international

become a reality, a

research prize is that we would ignite worldwide scientific

cure for diabetes must

interest and innovation to find a cure for diabetes in

be found. Advancing

this generation,” said Harold Hamm, chairman and

progress toward a cure

CEO of Continental Resources, Inc., who provided the

was the impetus for

endowment to establish the prize.

establishing the $250,000 Harold Hamm International Prize for Biomedical Research in Diabetes, the largest

Hamm’s endowment of the prize provides for its

of its kind in the world, awarded by Harold Hamm

awarding in the future in perpetuity. This endowment

Diabetes Center at the University of Oklahoma.

represents a unique private/public partnership of using philanthropic dollars as a catalyst for desperately needed

The Hamm Prize recognizes and encourages lasting

medical advances, which is especially beneficial in

advances in the field of diabetes research. It is awarded

the current environment marked by declining federal

to an individual who has either demonstrated lifelong

funding for medical research.

contributions to the field or realized a singular advance, especially in leading toward a cure.

“I am grateful to Harold Hamm for establishing this important prize and for the leadership and tenacity

The 2015 recipient, Dr. C. Ronald Kahn, has done both.

he has demonstrated by taking action to address the

One of the greatest medical researchers of this generation,

diabetes health crisis,” said OU President David L.

he has devoted his career to exploring the mechanisms

Boren. “This prize is another example of the forward

of insulin’s interactions in the body. His findings are

momentum of Harold Hamm Diabetes Center’s efforts

basic to the understanding of diabetes and have informed

to end diabetes."

virtually every new treatment for diabetes developed over the last 50 years.

Kahn was selected by a jury of international leaders in the field of diabetes. The selection jury was tasked with

Kahn is a world recognized expert in diabetes and obesity

selecting the recipient who has had, and will continue

research as well as a preeminent investigator in the area

to have, a lasting impact on the field of diabetes, with

of insulin signal transduction and mechanisms of altered

special emphasis on progress toward a cure.

signaling in diabetes and metabolic disease. His work continues to inspire still more groundbreaking research

Dr. Kahn’s contributions to understanding insulin

across the globe that moves the world of medicine ever

and its role in diabetes has affected how virtually all

closer to a cure.

researchers approach the disease. “Dr. Kahn is one of the most accomplished medical researchers of our generation.

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The Hamm Prize Laureate is selected by a jury of five internationally recognized leaders in the field of diabetes. The 2015 selection jury included: • E leuterio Ferrannini, M.D., Ph.D., Professor of Internal Medicine at the University of Pisa School of Medicine and Chief of the Metabolism Unit at the National Research Council Institute of Clinical Physiology

Dr. Ronald Kahn, 2015 Prize Laureate

His work in insulin signaling and insulin action laid the foundation on which thousands of researchers build their work today,” said Dr. Kenneth Copeland, chairman of the Selection Jury and director of Harold Hamm

• G eorgeanna Klingensmith, M.D., Chief of Pediatric Clinics at the Barbara Davis Center for Diabetes and Professor of Pediatrics at the University of Colorado School of Medicine • R obert Rizza, M.D., Professor of Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition at the Mayo Clinic

Diabetes Center–Children's. “Certainly, one day we hope to have a real cure for diabetes, and that cure will no doubt be as a result of the foundation Dr. Kahn’s research has built.”

• E lizabeth Seaquist, M.D., Pennock Family Chair in Diabetes Research, Professor of Medicine at the University of Minnesota Medical School

The Hamm Prize was awarded to Kahn on October 26, 2015, in Oklahoma City by Hamm and Boren at the 2015 Connect+Cure Gala benefiting Harold Hamm Diabetes Center. To learn more about the Hamm Prize, please visit www.HaroldHammPrize.org.

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• G ordon Weir, M.D., Senior Investigator, Diabetes Research and Wellness Chair at Joslin Diabetes Center and Professor of Medicine at Harvard Medical School

2015 Connect+Cure Gala

Breaks Attendance and Fundraising Records

The 2015 Connect+Cure Gala benefiting Harold Hamm Diabetes Center cast a bright light on the escalating diabetes epidemic and how HHDC is responding to it by leading the way to prevent, treat, and ultimately find a cure for diabetes. Diabetes impacts everyone in our society, and as the centerâ&#x20AC;&#x2122;s flagship community fundraiser, Connect+Cure draws together members of the community to support the important work of reducing the impact of diabetes on us all. Those in attendance represented a diverse group of stakeholders focused on curbing the alarming growth of diabetes in Oklahoma, the region, and the world. Proceeds from the gala provide financial support for a myriad of diabetes research, patient care, and prevention programs.

The event featured the official conferral of the Harold Hamm International Prize for Biomedical Research in Diabetes to Dr. C. Ronald Kahn of the Joslin Diabetes Center at Harvard Medical School. This $250,000 prize, the largest of its kind in the world, recognizes and Distinguished NBC News journalist Harry Smith emceed the eveningâ&#x20AC;&#x2122;s

promotes lasting achievements that are leading us to one day living in

program.

a world free of diabetes.

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This yearâ&#x20AC;&#x2122;s event had a record-breaking crowd of nearly 900 supporters eager to learn more about the impact the center is having both in Oklahoma and around the nation.

The Connect+Cure gala was honored to host Diabetes Daily Grind, a popular blog offering real life advice for people with diabetes. Its founders, Oklahomans Amber Clour and Ryan Fightmaster, recorded a Real Life Diabetes Podcast at the event, featuring the stories of several gala guests touched by diabetes as well as HHDC healthcare providers and the Hamm Prize Laureate, Dr. Ronald Kahn. Join the converstation at www.diabetesdailygrind.com

Guests enjoyed entertainment by Oklahomaâ&#x20AC;&#x2122;s own Toby Keith.

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New Space to Promote Healthy Eating

At Harold Hamm Diabetes Center, we work to empower our patients to manage their diabetes so that they can avoid complications and enjoy the best possible quality of life. Among the most important cornerstones for doing so is maintaining a healthy diet. However, most anyone knows that making healthy food choices is easier said than done. Thanks to a gift this year from the Chickasaw Nation, the center is beginning construction on a teaching and demonstration kitchen that will showcase and teach the many different, sustainable ways to make healthy eating an everyday habit. In addition, this gift will enable the center to work toward developing new partnerships to install technology that can broadcast these classes across the state, especially to rural and underserved communities. The kitchen will be part of the center's Diabetes Life Clinic, which offers a varity of services focusing on developing life skills to live healthy with diabetes.

A healthy diet is critical for those living with diabetes, as well as those hoping to prevent developing the disease. Yet, many people have never been taught how to plan and prepare healthy, affordable meals. Thanks to a gift from the Chickasaw Nation, HHDC is beginning construction on a teaching and demonstration kitchen to teach and promote sustainable healthy eating habits.

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Dr. Kevin Short at Harold Hamm Diabetes Centerâ&#x20AC;&#x201C;Children's

New Study Focused on Exercise and Diet In September Dr. Kevin Short, Associate Professor and CMRI Choctaw Nation Endowed Chair in Pediatric Endocrinology, received a new grant this year to conduct a study on the role of exercise and diet in vascular health in adolescents. Made possible by a generous gift from the Ardmore Institute of Health, the study is designed to generate critical preliminary data that will extend the centerâ&#x20AC;&#x2122;s research on the roles of obesity, diabetes, and fitness on arterial compliance, a key measure of vascular health that is predictive of future cardiovascular disease. Dr. Short and his team will generate preliminary data with a newly acquired instrument that will measure how a single exercise session or a high-fat meal impacts arterial compliance in normal weight versus obese adolescents.

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Summer Camp No Longer Out of Reach for Children with Type 1 Diabetes

H A ROL D H A M M DI A BET E S CE N T E R

Summer camp is a fond memory many have from their childhood years. For children with type 1 diabetes, however, attending camp is most often not possible because of the around-the-clock care and management diabetes requires. That changed this year for 20 of HHDC's pediatric patients. Through a partnership with Cavett Kids Foundation’s annual Kamp Courage, they got to experience all the usual camp activities like archery, hiking, arts and

Pro golfer and HHDC Board Member Scott Verplank coaches a camper.

crafts, swimming, ropes courses, games, and more, all in a medically safe environment. The health and safety of campers was ensured by 24-hour care and supervision from HHDC’s team of board-certified pediatric endocrinologists, Certified Diabetes Educators, nurses, registered dietitians, clinical psychologists, pharmacists, and medical counselors. In addition to offering a true summer camp experience, the camp also provided an opportunity for campers to learn more about the management of their chronic condition. From teaching children how to administer insulin to building self-esteem and self-confidence, camp provided a unique way for children with type 1 to render what was once a terminal illness into a

Campers “count the carbs” in every

manageable disease that does not keep them from living a full life. In perhaps

meal before eating, to anticipate insulin

the biggest highlight of the camp, this was emphasized by a visit to camp

response.

from Oklahoma's own Scott Verplank, a world championship golfer with type 1 diabetes himself, who served as a role model for all that by properly caring for themselves, those living with type 1 diabetes can pursue and achieve their dreams. For many of our campers, it was literally the first night they had spent away from home since their diagnosis. Thanks to a gift from Continental Resources, Inc., there was no cost to the children and their families to attend. Through grants and increased financial support from our donors, we anticipate more than doubling the number of children who can attend in 2016. An adventurous camper navigates the ropes course.

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PROTECT2 Study will Evaluate New Program to Reduce Blindness from Diabetes Diabetic eye diseases like retinopathy and macular edema are leading causes of blindness and vision loss among adults in the United States and worldwide. Yet, more than 50 percent of those with diabetes do not receive universally recommended eye examinations to detect diabetic eye diseases. As a result, many are not diagnosed in time to benefit from proven treatment options, such as laser surgery which has been proven in NIH clinical trials to prevent 90 percent of the vision loss caused by diabetic retinopathy. The reasons cited for patients not getting their eye exams include income, race, ethnicity, lack of health insurance, transportation, communication with eye doctors, the cost of eye examinations, social support, and fear of medical or surgical treatment. In addition, an eye exam and diabetic retinopathy care plan involve the coordination of a complex network of primary care providers and endocrinology specialists, optometrists, comprehensive ophthalmologists, retinal specialists, insurance plans, community-based organizations, and more. This can be intimidating to patients and creates barriers that prevent them from receiving the eye care they need. To help address these issues, Harold Hamm Diabetes Center was selected this year as the first site in the nation to begin enrolling patients in the PROTECT2 study, a new translational research study led by principal investigator Dr. James Lane, Director of Adult Clinical Services at HHDC. PROTECT2 includes a new eye test that will be performed at HHDC during a routine office visit. The test assesses a patientâ&#x20AC;&#x2122;s risk for vision-threatening diabetic retinopathy using a new hand-held device that measures the electrical activity of the retina, like an electrocardiogram measures the electrical activity of the heart. The test was shown to be 99 percent accurate in a study recently published by a team led by Dr. Stephen Fransen of the Dean McGee Eye Institute. The test takes less than five minutes and does not require dilation. Dr. Fransen is also an Associate Professor in the Department of Ophthalmology in the OU College of Medicine, and a Member of HHDC.

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Patients found to be at increased risk will be paired with a care coordinator to help them develop and implement their personalized care plan. The scope of services provided by the care coordinator will depend on the patientâ&#x20AC;&#x2122;s needs. Some patients may only need assistance making sure that the results of their risk assessment test are available to all of their providers. Other patients will need additional services, such as making appointments, transportation, explanation of their insurance coverage, or financial assistance to cover the costs of their care. The PROTECT2 study will measure the ability of this program to improve the quality, efficiency and cost-effectiveness of retinopathy care for patients with diabetes. Dr. Fransen is the president of Retinal Care LLC, a health services company spun out of the University of Oklahoma in 2014 to bring this program to patients with diabetes nationwide. The long-term goal is to eliminate blindness and vision loss caused by diabetes, by ensuring all patients receive the right care in the right place, at the right time, and by the right person.

Nine in ten people with prediabetes donâ&#x20AC;&#x2122;t know they are at high risk. Learn about T2D risk factors and warning signs and answer a few quick questions to find out whether additional testing might be recommended for you. The American Diabetes Associationâ&#x20AC;&#x2122;s Risk Test is available on our website. www.haroldhamm.org/diabetesprevention/risk.aspx

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First and Only Pediatric Clinical Trials Unit for Diabetes in Oklahoma Established

In April, the center established the DJH Foundation Pediatric Clinical Trials Unit for Diabetes thanks to a generous gift from the DJH Foundation. This is the first and only pediatric clinical trials unit for diabetes in Oklahoma. It offers Oklahoma children access to the

This the second contribution to HHDC from the DJH Foundation, which was created in 2007 by Muldrow residents Donald and Joyce Harvey and aims to prevent and control cancer, asthma, and diabetes in children.

most advanced diabetes treatments and therapies currently available. The unit also serves as a critical component of the center's efforts to contribute to the advancement and understanding of the best treatments for children with diabetes, making significant contributions to the scientific community.

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Program Aspires to Standardize Care in Pregnancy Each year, about 400 of the baby deliveries occurring at OU Medical Center are affected by pre-gestational or gestational diabetes. To effectively address these conditions, mothers require access to a number of physicians and specialties. However, they must often navigate a patchwork of clinics, provider recommendations and medical guidelines. To address this issue and better serve expecting mothers, work has begun to establish the Center for Diabetes in Pregnancy (CDP) through a grant from Harold Hamm Diabetes Center, in partnership with the Department of Obstetrics and Gynecology within the OU College of Medicine. Led by Dr. Christina Scifres, a maternal-fetal medicine specialist, and Dr. Madona Azar, an adult endocrinologist, the CDP has three critical targets: to direct more women into preconception counseling, to increase early gestational-diabetes screening among high-risk women who become pregnant, and to facilitate timely referral for evaluation and treatment once gestational diabetes is diagnosed. These efforts will result in both healthier moms and babies.

Navigating through the treatment options needed to effectively manage diabetes can be overwhelming. Many people living with diabetes don't even know the services that are available to them, or why it is important to seek care to live well with diabetes. Websites are nice, but sometimes you want it in print. New for 2015, our services guide outlines all our multidisciplinary care programs for patients plus clinical trials, groups and classes, diabetes prevention programs, location maps and more. It's free and available throughout our flagship building in OKC. Call (405) 271-2824 to request a copy by mail.

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Chickasaw Nation Scholars Endowment Established

With the increasing incidence of people diagnosed with diabetes and seeking care for the disease, there is a shortage in the United States of approximately 1,500 adult and 100 pediatric full-time endocrinologists. This has a particularly severe impact on Oklahoma, as our state ranks seventh in the nation of the percentage of citizens with diabetes. For this reason, the recruitment of skilled physician-scientists, focused on diabetes clinical care influenced by the most up-to-date research, is among HHDCâ&#x20AC;&#x2122;s top priorities. Thanks to an endowment established this year from the Chickasaw Nation, the center has been given additional resources to recruit and retain the most talented diabetesfocused endocrinologists. Through this gift, two endocrinologists will be known as Chickasaw Nation Scholars and will be provided with recurring financial support each year to support their work leading to advances in patient care, prevention, and research. These added financial resources provided by the Chickasaw Nation will also make HHDC more competitive nationally in the market for an ever-stronger team of endocrinologists to meet the needs of people with diabetes in Oklahoma and beyond.

The old adage, "The first step is the hardest," is true for so many with diabetes. Our Diabetes Step 1 seminar added sessions and increased attendance in 2015. The free event is now held every other month in the Meinders Atrium. Itâ&#x20AC;&#x2122;s an opportunity for adults with diabetes to learn about the range of programs offered at Harold Hamm and to have their questions answered by clinicians. Pictured here at left is Certified Diabetes EducatorÂŽ Dianne Brown of our OU Physicians Diabetes Life Clinic.

H A ROL D H A M M DI A BET E S CE N T E R

ove to Cook L LEARNING SERIES

Oklahoma ranks as the 5th least healthy state in the nation and has the 6th highest rate of obesity. One reason for this ranking is unhealthy food choices. Dietitians at Harold Hamm Diabetes Center aim to change that through a new cooking program. Love to Cook Learning Series is a free program offered by the HHDC Diabetes Life Clinic in partnership with the USDA Supplemental Nutrition Program (SNAP). The series promotes healthy eating habits and cooking techniques through demonstrations, nutrition education, and wellness information. Attendees sample and learn how to prepare many recipes at home including lean meats, healthy soups, side dishes, various fish, vegetables and carb friendly desserts. All the recipes and nutrition information used are verified by registered and licensed dietitians to ensure the quality of the recipes. The curriculum is based on contemporary tools like the USDA's MyPlate and the Dietary Guidelines for Americans. Six Love to Cook sessions were offered in 2015. Participants walk away from these classes empowered to make healthy food choices and with various recipes to prepare at home.

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Five-year-long clinical trial completed Through Clinical Trials at Harold Hamm Diabetes Center, patients gain access to cutting-edge treatments before they are widely available. They also help others by contributing to medical research that leads to better treatment methods. This year, the center completed the five-year-long trial Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results, sponsored by Novo Nordisk. With more than 9,000 patients at sites in 30 countries worldwide, HHDC achieved a 100 percent retention rate among our patients in the trial. With a typical clinical trial at HHDC lasting anywhere from 26 to 52 weeks, the participation of patients for five years is particularly noteworthy, resulting in increased knowledge gained from the trial that will lead to better treatment options for those with diabetes and diabetes related complications. The full results of the trial will show the tested treatment's effect on cardiac function and disease, which are among the most common and fatal complications caused by diabetes.

Center Hosts Oklahoma Diabetes Caucus Launch Recognizing the growing prevalence of diabetes in Oklahoma, leaders of the state legislature established the Oklahoma Diabetes Caucus in 2015 with the goal of advocating for policies and other proactive partnerships to help address the epidemic in our state. Led by Senator Susan Paddack of Ada, Representative Jeannie McDaniel of Tulsa, and Representative Lee Denney of Cushing, the caucus partners with a wide range of healthcare and community leaders from across the state, including Native American tribal health leaders, nonprofit organizations, healthcare providers, and interested corporate partners. The center was proud to host the kick-off event in February and help facilitate bringing these people together.

H A ROL D H A M M DI A BET E S CE N T E R

Providing Options for People at High Risk for Type 2 Diabetes — While There is Still Time For the one in three adults who have prediabtes, there is still time to intervene and prevent full development of type 2 diabetes. A proven diabetes prevention program based on curriculum from the U.S. Centers for Disease Control and Prevention Diabetes Prevention Program, HHDC’s Small Steps, BigChanges empowers patients to lose weight, reduce cholesterol levels, and lower blood pressure. It also focuses on increasing people’s self-confidence, which often inhibits them from truly believing they can make healthy lifestyle habits and see results. This year, 100 percent of the Small Steps, Big Changes participants successfully completed the 16-week core program, with 88 percent of the participants demonstrating an improvement in both their weight and blood glucose levels. A new round of Small Steps, Big Changes began in December with a focus on low-income individuals and families. Program materials and need-based fee waivers for Small Steps, Big Changes participants were made possible through the continued support of the Anschutz Foundation. Also this year, the center introduced a train-the-trainer program for Small Steps, Big Changes, allowing interested healthcare professionals to become certified lifestyle coaches who can then lead individuals through the healthy lifestyle program. This train-the-trainer program includes an intensive education on facilitating Small Steps, Big Changes as well as continued monitoring and mentorship after participants are certified as lifestyle coaches.

HHDC administrator Blake Rambo shares data on Oklahoma’s diabetes epidemic, enumerates the center’s initiatives, and leads a Sen. Susan Paddack of Ada represents Oklahoma Senate District 13.

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tour of our facility.

H A ROL D H A M M DI A BET E S CE N T E R

2015 SYMPOSIUMS, LECTURES, & SEMINARS

Academic symposiums like the annual Harold Hamm Research Symposium are critical to academic researchers, providing opportunities for open discussion about new developments in research and innovative studies. Our Research Symposium is a forum for scientists in diabetes basic science, translational research, and clinical research to present their data and receive immediate responses from peers in the diabetes research community.â&#x20AC;&#x2030;The symposium begins with oral presentations and discussion supplemented by poster presentations.â&#x20AC;&#x2030;The day ends in a keynote address and a reception where awards for best presentations are given to participants in each field. KEYNOTE ADDRESS Gut Microbiota, Low-Grade Inflammation, and Metabolic Syndrome

Andrew Gewirtz, Ph.D. University Center Professor Center for Inflammation, Immunity & Infection Institute for Biomedical Sciences, Georgia State University

H A ROL D H A M M DI A BET E S CE N T E R

RESEARCH SYMPOSIUM

ORAL PRESENTATIONS FIRST PLACE

Elizabeth Moran PPAR α restores the circadian rhythm in diabetes to modulate EPC release and alleviate diabetic retinopathy Co-Contributors: Rui Cheng Lexi Ding Zhongxiao Wang Kelu Zhou Rafal Farjo Alain Quiambao Mike Kinter Jian-Xing Ma SECOND PLACE

Jami Gurley Endurance exercise-dependent increase in skeletal muscle GLUT4 expression in mice occurs through a posttranscriptional mechanism Co-Contributor: Ann Louise Olson THIRD PLACE

Shaoning Jiang Effects of maternal diabetes on PGC-1α expression in placenta: role of microrna-130B Co-Contributors: April M. Teague Jeanie B. Tryggestad Dr. Andrew Gewirtz

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Steven D. Chernausek

RESEARCH SYMPOSIUM

POSTER PRESENTATIONS FIRST PLACE – Group A

SECOND PLACE – Group B

Xuemin He

Jessee Bustinza

Low-density lipoprotein receptor-related protein 5 drives

Neonatal diabetes: Case report of a 9-week old presenting

tubulointerstitial fibrosis via regulation of TGF-B signaling

in diabetic ketoacidosis due to an activating ABCC8

Co-Contributors:

gene mutation

Rui Cheng

Co-Contributors:

Kyungwon Lee

Shawn Sood

Yusuke Takahashi

Roopa Thukaram

Jian-Xing Ma

Laura Chalmers

SECOND PLACE – Group A

FIRST PLACE – Group C

Qian Chen

Sang-Min Lee

Differential roles of very low density lipoprotein receptor

Receptor activity-modifying protein-mediated peptide

splice variants in regulating WNT/β-Catenin signaling

interactions at the calcitonin receptor: A hypothesis of

Co-Contributors: Yusuke Takahashi

allosteric mechanisms for enhanced affinity of antidiabetic amylin

Kyungwon Lee

Co-Contributor:

Kazuhiro Oka

Augen A. Pioszak

Jian-Xing Ma SECOND PLACE – Group C FIRST PLACE – Group B

Deepa Sathyaseelan

Robert Jackson

Improved insulin sensitivity in a mouse model deficient in

Diet Composition impacts insulin sensitivity and adipose

mitochondrial protease ClpP

depot composition Co-Contributor: Ann Louise Olson

H A ROL D H A M M DI A BET E S CE N T E R

Elizabeth Moran delivers the presentation that won her the Symposiumâ&#x20AC;&#x2122;s top honor.

ORAL PRESENTATIONS The regulation of glucose transport is altered during diabetesinduced atrial fibrillation

Zahra Maria Endurance exercise-dependent increase in skeletal muscle GLUT4 expression in mice occurs through a posttranscriptional mechanism

Jami Gurley y-Secretase inhibition leads to decreased adipose macrophage content

David Sparling Patients with diabetes mellitus are predisposed to disorders Sang-Min Lee (left) is presented a first-place award for his research

of cerebrospinal fluid circulation after subarachnoid

poster by Dr. Ann Louise Olson, Lead Judge for the Symposium.

hemorrhage

Ayumi Ludwig Acceptability and feasibility of a culturally specific nutrition intervention among African Americans with Type 2 diabetes in an outpatient clinic setting

Micki Hall Nadelson

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H A ROL D H A M M DI A BET E S CE N T E R

RESEARCH SYMPOSIUM

Oral Presentations (continued) A novel device for accurate and efficient testing for visionthreatening diabetic retinopathy

Stephen R. Fransen Effects of maternal diabetes on PGC-1α expression in placenta: role of microrna-130B

Shaoning Jiang Measuring the effect of maternal DM on fetal cord blood vascular endothelial growth factor

Jonathan Meyer Protection of pancreatic beta cells against ER stress by a small molecule furanochrome

Daleep Arora PPAR α restores the circadian rhythm in diabetes to modulate EPC release and alleviate diabetic retinopathy

Elizabeth Moran Functional mutations in GCKR, detected through target sequencing, affect triglyceride concentrations in type 2 diabetes

Bishwa Sapkota SH3 domain binding kinase 1 is a novel regulator of hepatic gluconeogenesis

Chi Bun Chan Maternal transmission of dietary sugars through breast milk

David Fields Decreased expression of protein kinase inhibitor (PKI) in the diabetic heart

Kenneth Humphries Attendees browse the Symposium’s poster presentations

Mathematical modeling of podocytes in diabetic kidney disease

Ashlee Ford Versypt

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RESEARCH SYMPOSIUM

POSTER PRESENTATIONS

Inhibitory effect of proximal tubular cells-derived

Differential roles of very low density lipoprotein receptor

Rui Cheng

splice variants in regulating WNT/Î˛-Catenin signaling

Qian Chen

Mathematical modeling of podocytes in diabetic kidney disease

Ashlee Ford Versypt

neuropilin-1 in TGF Beta signaling pathway

Diet Composition impacts insulin sensitivity and adipose depot composition

Robert Jackson Biological significance of binding and activation of the receptor for advances glycation end products by

Higher fasting glucose is associated with poorer cognition

the neutrophil-derived protein CAP37 in proliferative

among healthy young adults

retinopathies

Misty Hawkins

Anne Kasus-Jacobi

Low-density lipoprotein receptor-related protein 5 drives

A genome-wide association study identifies FOXA2 to be

tubulointerstitial fibrosis via regulation of TGF-B signaling

associated with circulating 25(OH)D levels

Xuemin He

Bishwa Sapkota

Retinal neuronal MTDNA alterations in a rodent model of

Receptor activity-modifying protein-mediated peptide

diabetic retinopathy

interactions at the calcitonin receptor: A hypothesis of

Dustin Masser

allosteric mechanisms for enhanced affinity of anti-

Effect of diabetes-associated metabolic factors on placental growth factor in skeletal muscle cells

Farzana Rouf Neonatal diabetes: Case report of a 9-week old presenting in diabetic ketoacidosis due to an activating ABCC8

diabetic amylin

Sang-Min Lee Calorie restriction significantly alters the intestinal microbiota of C57BL/6J mice

Stephanie Matyi

gene mutation

Improved insulin sensitivity in a mouse model deficient in

Jessee Bustinza

mitochondrial protease ClpP

Prolonged hyperinsulinemia affects metabolic signal

Deepa Sathyaseelan

transduction markers in a tissue specific manner

Allison Campolo

H A ROL D H A M M DI A BET E S CE N T E R

RESEARCH SYMPOSIUM

Poster Presentations (continued) Proteomic analysis of cardiac secretome in mice protected

Rat genome-wide capture of gene regulatory regions and

against diabetes

base-resolution quantitation of DNA methylation

Shanell Shoop

David Stanford

Effect of genotype and different levels of dietary restriction

Endoglin is increased in umbilical cord serum from diabetic

on glucose tolerance

pregnancies and correlates with maternal glycemia

Archana Unnikrishnan

April Teague

RPE barrier breakdown in diabetes, is it real?

Differential expression of micro-RNA in human umbilical

Yun-Zheng Le

vein endothelial cells from infants of diabetic mothers.

Pancreatic beta cell protection and reversal of hyperglycemia

Jeanie Tryggestad

in diabetic animals by a small molecule through

A new regulator of SIRT1 protein turnover regulated by

mitigating ER stress

endothelial nitric oxide

Yu Li

Junhui Xing

Incentivizing physical activity in American Indian youth

Kevin Short

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Lectures & Symposiums

The HAMM LECTURE in DIABETES RESEARCH THE UNIVERSITY OF OKLAHOMA Dr. C. Ronald Kahn, 2015 Hamm Prize Laureate, delivered the 2015 Hamm Lecture. Held every other October on the OUHSC campus, the lecture is an opportunity for the public to hear directly from the most preeminent in the field. In his talk, entitled How Genes and Environment Interact to Cause Diabetes and Metabolic Syndrome, Dr. Kahn emphasized the role the gut microbiome plays in originating and potentially controlling diabetes.

H A ROL D H A M M DI A BET E S CE N T E R

LECTURES & SYMPOSIUMS CMRI Jack & Evelyn Trachtenberg Visiting Professor Department of Pediatrics, Section of Diabetes and Endocrinology Established in 2004 by the generosity of the Larry and Mary Trachtenberg family and by Children’s Hospital Foundation, the Jack and Evelyn Trachtenberg childhood diabetes endowment provides the resources to enhance diabetes research and teaching in the state of Oklahoma by inviting national leaders in the field of diabetes research to speak on the campus of the University of Oklahoma Health Sciences Center.

How Growing Up Sweet Can Turn Sour: Sugars, Obesity and Metabolic Risk during Growth

Sara Pinney, M.D. Attending Physician Division of Endocrinology and Diabetes The Children’s Hospital of Philadelphia

SYMP SIUM Two thousand fifteen The 2015 Harold Hamm Diabetes Center Symposium in April featured a roundtable discussion by members of the selection jury for the

Kelly West Lectureship

Department of Medicine, Section of Diabetes and Endocrinology In honor of Kelly West, known as the “father of diabetes epidemiology,” this lectureship hosts world-renowned experts in diabetes research.

Harold Hamm International Prize.The symposium concluded with a panel discussion during which the distinguished jurors candidly discussed the prospect of discovering cures for diabetes and its complications.

The Changing Incidence of Diabetic Retinopathy: An Epidemiologic Perspective

Ronald Klein, M.D., M.P.H. Professor Department of Ophthalmology and Visual Sciences School of Medicine & Public Health University of Wisconsin-Madison

Henry Turner Lecture

Department of Medicine, Section of Diabetes and Endocrinology Henry Turner established one of the first radioisotope laboratories in Oklahoma and is known for correctly identifying the phenotypic symptoms of what is now known as the Turner-Ullrich Syndrome

Recent Developments in Primary Aldosteronism

Celso E. Gomez-Sanchez, M.D. Professor Department of Medicine School of Medicine University of Mississippi Medical Center

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The Selection Jury for the 2015 Harold Hamm International Prize comprised some of the world’s leading scientists. They are, from left, Dr. Gordon Weir of Joslin Diabetes Center, Harvard; Dr. Elizabeth Seaquist of the University of Minnesota Medical Center; Dr. Georgeanna Klingensmith of Barbara Davis Center for Diabetes, University of Colorado; Dr. Robert Rizza of the Mayo Clinic; and Prof. Eleuterio Ferrannini of the University of Pisa (Italy) School of Medicine.

CONTINUING MEDICAL EDUCATION

Beyond the Basics Beyond the Basics is offered by annually by HHDC as a continuing education program for health professionals, promoting excellence in care and conveying up-to-date, practical strategies and information integral to the effective management of diabetes.

Attendees interact with vendor exhibitors.

Psychologist Dr. Cynthia Muhamedagic of HHDCChildrenâ&#x20AC;&#x2122;s presents at Beyond the Basics 2015 on the

role of behavioral health in transitioning a patient

Attendees engage in an afternoon session at Beyond

from pediatric to adult diabetes care.

the Basics 2015.

H A ROL D H A M M DI A BET E S CE N T E R

CONTINUING MEDICAL EDUCATION

Pharmacist and OU-Tulsa Assistant Professor Dr. Jeremy Johnson discusses the common financial barriers to diabetes care.

Beyond the Basics 2015 Presentations The Role of the Community Health Worker in Diabetes

Strategies for Managing Type 2 Diabetes on a Budget

Self-Management

Jeremy L. Johnson, Pharm.D., C.D.E.

Micki Hall, M.S., R.D., L.D., C.D.E.

Approaches to Improving Medication Adherence and

Diabetes and Dental Complications

Overcoming Barriers in Patients with Type 2 Diabetes

Kay S. Beavers, D.D.S.

Katherine Oâ&#x20AC;&#x2122;Neal, Pharm.D., M.B.A., B.C.A.C.P., C.D.E. B.C.-A.D.M., A.E.-C.

Advances in Pharmacotherapy for the Treatment of Obesity

Albina Gosmanova, M.D. Transitioning from Pediatric to Adult Diabetes Care: Behavioral Healthâ&#x20AC;&#x2122;s Role

Ethics for Diabetes Educators when using Blogs, Social Media or the Electronic Health Record

Kelly Curran, M.D., M.A.

Cynthia Muhamedagic, Ph.D.

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H A ROL D H A M M DI A BET E S CE N T E R

COMMUNITY of Support

The diabetes epidemic Now let's end it.

We're moving closer every day to ending diabetes, thanks to the generous support and commitment of the many individuals, foundations, companies, and organizations that made a gift this year. 412 Dozer Service Inc. Ackerman McQueen Inc. Bobby and Brenda Alexander Bill Anoatubby The Anschutz Foundation Ardmore Institute of Health David L. Arms ASTEC Charter School Ronald W. Atchley Backyard Energy Services LLC Jason Don Baker BancFirst Bank of America Franklin J. Bavendick Shelley A. Beall Bear Creek Ranch, Inc. Terry Beck Andy Behrens Robert B. Berry Billingham Agency LLC Catherine F. Bishop Elizabeth Warren Blankenship Barbara Boatman Bob’s Oilfield Service, Inc. James P. Boggs David and Molly Shi Boren Lori Neal Bowman Stephen G. Bradley Linda Bridges Mary Ellen Bridwell John T. Brogan Glen A. Brown Linda D. Brown Mary Dianne Brown Pete and Barbara Brown Melanie Burdick Bob G. Burke Carol J. Burr Michael Burrage Virginia D. Calame 40

Lynn Cappon Cathy Carmichael Fred and Meg Carr Pat Carr Roger Chasteen Cherokee Lions Club Cherokee Nation Chesapeake Operating, Inc. Chickasaw Nation Choctaw Nation of Oklahoma Mark S. Christian Commerce Bank Compass Bank Conner & Winters LLP Continental Resources, Inc. Kenneth C. Copeland Terry L. Cotterell Kenneth J. Cottrill John F. Coury CPI Pipe & Steel, Inc. Joseph W. Craft Tom Cronin Deana Ann Cunningham William T. Dame Fred Daniel III Joshua C. Davis Rick E. Dawson Dean A. McGee Eye Institute Jared M. DeShields Devon Energy Corporation Nance Langdon Diamond Dillingham Agency, LLC Christopher Ditzel Dobson Family Foundation Downing Wellhead Equipment, Inc. Downstream Development Authority of the Quapaw Tribe Carole J. Drake Jim R. Dyche

Frank G. Eby ECFE Ward Family Echo Energy LLC Carl and Susan Edwards E.L. & Thelma Gaylord Foundation Richard F. Ellis Enable Midstream Partners Enid Typewriter Company Barbara L. Eskridge Janet H. Eskridge Cheryl L. Evans George H. Evans Tom G. Evans Faith Mary Everest James H. Everest Russell D. Evitt Fellers Snider Robin F. Fields FirstBank Joan Newton Fleetwood James A. Ford Peggy Franklin Mrs. Henry Freede Don Freymiller FSB Architects Livia Garcia GE Global Research John D. Gibbs Gillispie & Ogilbee, P.C. Marlin ‘Ike’ Glass Gary E. Gould Robert J. Grant Chuck Greenwood Peter H. Gries John D. Groendyke Gungoll, Jackson, Collins, Box & Devoll P.C. Susan M. Hall Harold Thomas Hamm Nathaniel Harding

H A ROL D H A M M DI A BET E S CE N T E R

started in our lifetime. Katherine Harrell Jayne M. Hartung Hartzog, Conger, Cason & Neville Carol C. Hefner Peggy V. Helmerich Elizabeth Lane Hines Debra Hitzelberger Joseph Hodges Katie Hoefling E. Peter Hoffman Sarah C. Hogan Jennifer Holmes Ethan House Howard Family Charitable Foundation, Inc. Larry O. Hulsey Huntington Energy, Inc. Joanne Ingle Insurica Ronnie K. Irani Michael Scott Isaac V.A. Isaacs Jackfork Land Inc. Linda K. James Tom James James H. Everest Family Trust JMA Energy Company, LLC Journey of Hopes & Dreams Foundation Dianna H. Kakish Kendra Scott Design, Inc. Barbara L. Kerrick Kirk Kinnear Robert R. Klabzuba David J. Knapp Sue Ella Krenger Joseph A. Kuhn Brent W. LaGere Laird & Walkingstick Insurance Gant and Shelly Lambertz Anthony Larussa Lathrop & Gage Latshaw Drilling Company LLC Lawton Noon Lions Club Yun Zheng Le Le Norman Operating, LLC Lisa Ellen Lee 2 015 A N N UA L R E P O R T

Partners for Progress Italicized names on this list denote 2014-2015 members of Partners for Progress, Harold Hamm Diabetes Centerâ&#x20AC;&#x2122;s annual fund. Contributions from Partners for Progress are the foundation on which the center is built, touching every aspect of diabetes research, patient care, and prevention.

Lance Leonard Mark Lester Lowry Land Co. Lucky Services Inc. Manhattan Construction Company The Marcus Corporation Mark and Tracie Monroe Family Foundation Martha Marshall Debbie Martin Doris M. Martin Mary Marguerite Martin Harold and Patricia Mathena Mathis Brothers Furniture McAfee & Taft, P.C. McAnally Wilkins, Inc. Lon McCain Mary Gaylord McClean J. Michael McCoy Mark McCubbin Taylor Tubbs McDaniel Ella M. McDonald Mike McDonald McDonald Land Services, LLC Jeff J. McDougall Robert W. McGregor John and Darlene McNabb Herman and LaDonna Meinders The Meinders Foundation

Robert J. Melgaard Mrs. Harry Merson Joseph F. Messenbaugh III MidFirst Bank Robert L. Mills Melvin R. Moran Morgan Stanley Jill A. Mosley Berry and Regina Mullennix NAS Fluids Division Management Co. National American Insurance Company Larry and Linda Neal Terry Neese Personnel Services Theresa Neese Maurice and Mary Nickell Northwestern Mutual Foundation Thomas B. Nusz Gloria A Oâ&#x20AC;&#x2122;Brien Martha Ogilvie Christy Olson On A Whim ONEOK Foundation Patricia A. Parker Robert L. Parker Noah R. Parris Bobbie M. Parsons Glen R.. Patterson Pen & Quill Book Club Thomas A. Petrie 41

Harry H. Phillips James Rodney Phillips Phillips Murrah P.C. John Pierce Pinnacle Energy Services LLC Plains Marketing, L.P. Plaster & Wald Consulting Corp. Precision Drilling Presbyterian Health Foundation Gregory Price Rebecca E. Price Primary Natural Resources Steve Allen Privott QuiBids Holdings, LLC Gene Rainbolt Blake T. Rambo and Sean M. Cullen Laura Ratliff Geraldine Raupe

R. Kevin Redwine Renfro Family Foundation Eddie W. Rhea Rich & Cartmill, Inc. Riggs, Abney, Neal, Turpen, Orbison & Lewis T.J. and Ashleigh Riley Jonathan E. Rondon John Ryan Sacra Sammie Lee Smith Revocable Trust Sanford & Tatum Tana Sanger Nathan Sawyer Schlumberger Technology Corp. John Schmitz Loretta M. Seabrook Margaret Ann Short Richard L. Sias

Sidney Rental William D. Sinclair Skirvin Partners, LLC Stephen B. Slawson Mark Snyder Sarah Soell Daniel L. Somers Mike Somers W. Harvey Sparkman Terry Spencer Sarah B. Squire Jack H. Stark Mark Stokes Heather Dawn Summers Glenda Talbot Mike and Patricia Terry Bill D. Tharp Marilyn M. Tharp

Allocation of Philanthropic Funds 55.6% Endowed Chairs and Professorships 4.9%

Clinical Care

19.7%

Basic and Translational Research

1.3%

Prevention and Outreach

14.7%

Faculty and Member Support

3.8%

Program Enrichment

Gifts by Program 4.6%

Clinical Care

32.1%

Basic and Translational Research

23.0%

Prevention and Outreach

33.2% 7.1%

General Faculty and Member Support General Program Enrichment

H A ROL D H A M M DI A BET E S CE N T E R

Harolyne K. Thielke Karen D. Thingelstad Carolyn Thomas Arthur H. Thompson Thunder OKC Topographic Land Surveyors of Oklahoma Torcsill Foundations LLC Pat Tubbs University Hospitals Authority & Trust University of Oklahoma College of Medicine University of Oklahoma University of Oklahoma Foundation University of Oklahoma HSC Office of Senior Vice President and Provost Upshaw Insurance Valir Health, LLC

Rene Vassar Scott Verplank Sammie C Villines VK Enterprises, Inc. The Ben & Bonnie Walkingstick Foundation Dewey Wallace Mendy Michelle Watkins Wednesday Review Club WellPro, Inc. William G. Weppner Robert A. West West Family Foundation Michael W. Wheeler Lonney H. White Millar Barry White Thomas Lee White Albert Whitehead

Kristen Wilkerson Nancy C. Wilson Joseph C. Winkler Alta June Wood Skip W. Wood Nancy J. Woods Forrest Woolery Anne Wileman Workman WPX Energy Inc. Pat Wright Darlene Wynne Chuck Yates Don T. Zachritz ZZW Global, Inc.

Disbursement of Philanthropic Funds by Program 25.6%

Basic and Translational Research

28.0%

Clinical Care

22.1%

Prevention and Outreach

7.2%

General Faculty and Member Support

17.2%

General Program Enrichment

Number of Donors by Type 56.3%

Individual Gifts

22.3%

Businesses and Corporations

3.5%

Non-Profit Organizations

5.7%

Foundations and Trusts

5.7%

HHDC Staff, Faculty, and Members

6.6%

HHDC Board Members

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The Kelly West Society honors donors who have been a driving force behind the breakthroughs at Harold Hamm Diabetes Center through substantial gifts and commitments. The society is named for Dr. Kelly M. West, an esteemed researcher at the University of Oklahoma who is widely regarded internationally as the “father of diabetes epidemiology.” Dr. West’s passion to understand diabetes lives on in the thoughtful and innovative research, patient care, and prevention programs at Harold Hamm Diabetes Center supported by the generosity of members of the Kelly West Society.

Founders

Contributions of $1 million and more Harold Hamm Hille Family Charitable Foundation The Meinders Foundation Paul H. and Doris Eaton Travis The University of Oklahoma

Cherokee Nation The Chickasaw Nation Children’s Hospital Foundation Choctaw Nation of Oklahoma Continental Resources, Inc. George Kaiser Family Foundation

Benefactors

Contributions of $500,000 to $999,999 The Anne and Henry Zarrow Foundation Henry Zarrow

Patrons

Contributions of $100,000 to $499,999 Alliance Resource Partners, LP BlueCross BlueShield of Oklahoma David and Molly Shi Boren Britani Talley Bowman and Paul E. Bowman Chesapeake Energy Corporation Journey of Hopes & Dreams Foundation

MidFirst Bank National American Insurance Company Presbyterian Health Foundation John Schmitz William K. Warren Foundation

Partners

Contributions of $50,000 to $99,999 Mathis Brothers Furniture Mary Gaylord McClean Amy and Malone Mitchell 3rd Berry and Regina Mullennix Schlumberger Technology Corp. Sigma Phi Epsilon, Oklahoma Beta Chapter WellPro, Inc. Whitten Burrage Law Firm WPX Energy

The Anschutz Foundation Cyclone Drilling, Inc. Devon Energy Corporation E.L. and Thelma Gaylord Foundation Gungoll, Jackson, Box & Devoll, P.C. JEH Investments Linda Johnson Brent LaGere Le Norman Operating LLC

Supporters

Contributions of $20,000 to $49,999 Agio Ardmore Institute of Health BancFirst/Rainbolt Family Louise and Clay Bennett Jackie Cooper Dobson Family Foundation Enable Midstream Partners FirstBank Mrs. Henry Freede Grand Chapter of Oklahoma, Order of the Eastern Star Howard Family Charitable Foundation

JMA Energy Company Gant and Shelly Lambertz Manhattan Construction Company John and Darlene McNabb Herman and LaDonna Meinders ONEOK William D. Sinclair Smiths Medical M.D., Inc. Tenaris University Hospitals Authority & Trust Estate of Nathanial Waters

H A ROL D H A M M DI A BET E S CE N T E R

Board of Advisors The Harold Hamm Diabetes Center Board of Advisors recognizes

Regina Mullennix, Chair

that because of the increasing prevalence of diabetes and the toll

Dirk Oâ&#x20AC;&#x2122;Hara, Chair-Elect

it is taking on our health, there has never been a greater need to

Bill Anoatubby, Immediate Past Chair

support the mission of the Harold Hamm Diabetes Center.

Dewey Bartlett, Jr. Louise Bennett

The Board of Advisors is a group of volunteers dedicated to

James Boggs

advancing key initiatives of the Harold Hamm Diabetes Center

Barbara Brown

by employing their own personal talents, expertise, and resources.

Bob Burke

Board members serve as advocates in the community to increase

Mick Cornett

awareness of the urgency of the diabetes health crisis and how the

Somerlyn Cothran

center is responding. They also play a key role in the development

Joe Craft

of financial resources to strengthen the centerâ&#x20AC;&#x2122;s programs in

Tom Cronin

diabetes research, patient care, and prevention.

Rick Dawson Ike Glass Chuck Greenwood Mike Gundy Harold Hamm Nathaniel Harding Bob Howard Brent LaGere Shelly Lambertz Doug Lawler Vincent LoVoi Jeff McDougall Herman Meinders Berry Mullennix Rick Muncrief Leslie Rainbolt-Forbes

For his outstanding leadership, Chickasaw Nation Governor Bill Anoatubby (center)

T.J. Riley

was awarded Board Member of the Year for 2015 at the Connect+Cure Gala in October.

Meg Salyer

The presentation was made by current Board Chair Regina Mullenix (left) and Board

Mike Samis

Member Harold Hamm (right).

John Schmitz Bob Stoops Kristin Thomas Michael Turpen Scott Verplank

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Members, Faculty, and Staff Harold Hamm Diabetes Center has more than 125 members who comprise a coalition of diabetes-focused researchers, clinicians, and other healthcare professionals from diverse fields. The centerâ&#x20AC;&#x2122;s members represent institutions across the state of Oklahoma, including all three OU campuses, Oklahoma State University, Oklahoma Medical Research Foundation, the Oklahoma State Department of Health, and others. This has contributed to HHDC's serving as the focal point for addressing diabetes in Oklahoma, encouraging collaboration on novel research and innovative translational activities that will ultimately yield new treatments and therapies to the patient, and strategies to help people prevent diabetes.

MEMBERS Martin-Paul Agbaga, Ph.D.

Dean McGee Eye Institute Assistant Professor of Research Departments of Ophthalmology and Cell Biology College of Medicine Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center

Muayyad Al-Ubaidi, Ph.D.

Professor Vice Chair for Research Department of Cell Biology College of Medicine University of Oklahoma Health Sciences Center

Kermyt Anderson, Ph.D.

Associate Professor Department of Anthropology Colleage of Arts and Sciences University of Oklahoma

Robert Eugene Anderson, M.D., Ph.D.

Director of Research, Dean McGee Eye Institute George Lynn Cross Research Professor Dean McGee Professor of Ophthalmology Departments of Ophthalmology and Cell Biology Adjunct Professor Department of Geriatric Medicine College of Medicine University of Oklahoma Health Sciences Center

Madona Azar, M.D.

Assistant Professor Assistant Director, Fellowship Program Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center

Jo Azzarello, Ph.D., R.N.

Associate Professor College of Nursing University of Oklahoma Health Sciences Center

Mary Zoe Baker, M.D.

David Ross Boyd Professor Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Associate Chief of Staff for Education Oklahoma City VA Medical Center

Joni Beck, Pharm.D., B.C.-A.D.M., C.D.E.

Associate Professor and Clinical Programs Director Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Piers Blackett, M.D.

Clinical Professor Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

H A ROL D H A M M DI A BET E S CE N T E R

MEMBERS, FACULTY, AND STAFF

Laura Chalmers, M.D.

Assistant Professor Department of Pediatrics School of Community Medicine OU-Tulsa

Chi Bun Chan, Ph.D.

Assistant Professor Department of Physiology College of Medicine University of Oklahoma Health Sciences Center

Steven Chernausek, M.D.

CMRI Edith Kinney Gaylord Chair Professor Director, CMRI Pediatric Metabolic Research Program Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Carrie Ciro, Ph.D., O.T.R./L.,F.A.O.T.A.

Assistant Professor Department of Rehabilitation Sciences College of Allied Health University of Oklahoma Health Sciences Center

Alex Cohen, M.D., Ph.D.

Dean McGee Eye Institute W. Stanley Meunzler Endowed Professor of Corneal Disease Assistant Professor Co-Fellowship Director Department of Ophthalmology College of Medicine University of Oklahoma Health Sciences Center

Kenneth Copeland, M.D.

Director, Harold Hamm Diabetes Center-Childrenâ&#x20AC;&#x2122;s Paul and Ann Milburn Endowed Chair in Pediatric Diabetes Edith Kinney Gaylord Presidential Professor Section Chief, Section of Diabetes and Endocrinology Vice Chairman, Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Nicholas Davis, Ph.D.

Eduardo De Sousa, M.D.

Associate Professor Division of Neuromuscular Disorders Department of Neurology College of Medicine University of Oklahoma Health Sciences Center

Ferenc DeĂĄk, M.D., Ph.D.

Assistant Professor Reynolds Oklahoma Center on Aging Department of Geriatric Medicine Adjunct Professor Department of Physiology College of Medicine University of Oklahoma Health Sciences Center

Carol Dionne, P.T., D.P.T., Ph.D., O.C.S., Cert. M.D.T.

Associate Professor Rehabilitation Sciences Director, Mechanical Therapy Research Lab Adjunct Associate Professor, Allied Health Sciences Co-Director, RS Post-Professional Programs College of Allied Health University of Oklahoma Health Sciences Center

Michael Elliott, Ph.D.

Dean McGee Eye Institute Assistant Professor Department of Ophthalmology Adjunct Assistant Professor Department of Physiology College of Medicine Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center

Blas Espinoza-Varas, Ph.D.

Associate Professor Department of Communication Sciences and Disorders College of Allied Health University of Oklahoma Health Sciences Center

Krysten Farjo, Ph.D.

Assistant Professor Department of Physiology College of Medicine University of Oklahoma Health Sciences Center

Assistant Professor of Research Department of Medical Informatics School of Community Medicine OU-Tulsa

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MEMBERS, FACULTY, AND STAFF

Molly Fernando, Psy.D.

Qing Guo, M.D., Ph.D.

Clinical Psychologist Behavioral Health Coordinator, Prevention and Outreach Programs Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center

Professor Department of Physiology College of Medicine The University of Oklahoma Health Sciences Center

David Fields, Ph.D.

Professor Department of Biochemistry and Molecular Biology College of Medicine University of Oklahoma Health Sciences Center

CMRI Chickasaw Nation Chair in Diabetes Research Associate Professor Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Ashlee Ford Versypt, Ph.D.

Assistant Professor School of Chemical Engineering College of Engineering, Architecture, and Technology Oklahoma State University

Stephen Fransen, M.D.

Dean McGee Eye Institute Associate Professor Department of Ophthalmology College of Medicine University of Oklahoma Health Sciences Center

Willard Freeman, Ph.D.

Reynolds Chair in Aging Research Associate Professor Department of Physiology Adjunct Associate Professor Department of Geriatric Medicine College of Medicine University of Oklahoma Health Sciences Center

Andrew Gardner, Ph.D.

Donald W. Reynolds Chair in Aging Research Professor Department of Geriatric Medicine College of Medicine University of Oklahoma Health Sciences Center

Minu George, M.D.

Assistant Professor Medical Director, Pediatric Diabetes and Endocrinology Outpatient Clinics Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Jay Hanas, Ph.D.

Franklin Hays, Ph.D.

Assistant Professor Department of Biochemistry and Molecular Biology College of Medicine Adjunct Assistant Professor Department of Nutritional Sciences College of Allied Health University of Oklahoma Health Sciences Center

Kenneth Humphries, Ph.D.

Assistant Member Free Radical Biology and Aging Program Oklahoma Medical Research Foundation

David Jelley, M.D.

Director, Harold Hamm Diabetes Center-Tulsa Hille Chair in Diabetes Associate Professor Department of Pediatrics School of Community Medicine University of Oklahoma-Tulsa

Venkataraman Kalyanaraman, M.D.

Clinical Assistant Professor Section of Diabetes, Endocrinology and Metabolism Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Oklahoma City VA Medical Center

Dimitrios Karamichos, B.Eng., M.Sc., Ph.D.

Dean McGee Eye Institute Assistant Professor Departments of Ophthalmology and Cell Biology College of Medicine Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center

H A ROL D H A M M DI A BET E S CE N T E R

MEMBERS, FACULTY, AND STAFF

Anne Kasus-Jacobi, Ph.D.

Assistant Professor of Research Department of Pharmaceutical Sciences College of Pharmacy University of Oklahoma Health Sciences Center

David Kem, M.D.

George Lynn Cross Research Professor Regents Professor Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center

Michael Kinter, Ph.D.

Associate Member Free Radical Biology and Aging Program Oklahoma Medical Research Foundation Adjunct Associate Professor Department of Geriatrics College of Medicine University of Oklahoma Health Sciences Center

Gopan Krishnan, Ph.D.

Assistant Professor Bioanalytical and Clinical Sensor Research Department of Chemistry College of Arts and Sciences Oklahoma State University

Sowmya Krishnan, M.D.

James Lane, M.D.

Director, Harold Hamm Diabetes Center-Adult Clinical Services Harold Hamm Chair in Clinical Diabetes Research Professor and Section Chief Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center

Yun Le, Ph.D.

Choctaw Nation Chair in Diabetes Research Associate Professor Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center

Darren Lee, Ph.D.

Assistant Professor Department of Opthalmology College of Medicine University of Oklahoma Health Sciences Center

Misty Leyva, Ph.D., R.D./L.D.

Assistant Professor of Research Department of Health Promotion Sciences College of Public Health University of Oklahoma Health Sciences Center

Jonea Lim, M.D.

Assistant Professor Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Assistant Professor Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center

Biji Kurien, Ph.D.

Timothy Lyons, M.D., F.R.C.P.

Associate Professor of Research Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center

Veronique Lacombe, D.V.M., Ph.D.

Associate Professor Physiological Sciences Center for Veterinary Health Sciences Oklahoma State University Adjunct Associate Professor Department of Physiological Sciences University of Oklahoma Health Sciences Center

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Professor of Diabetes and Translational Medicine Director of the Diabetes Research Program Queenâ&#x20AC;&#x2122;s University of Belfast Professor of Research College of Medicine University of Oklahoma Health Sciences Center

Jian-xing Ma, M.D., Ph.D.

Director of Research, Harold Hamm Diabetes Center Laureate Professor and Chairman Department of Physiology College of Medicine University of Oklahoma Health Sciences Center

MEMBERS, FACULTY, AND STAFF

Rafael Malgor, M.D.

Assistant Professor Division of Vascular Surgery Department of Surgery College of Medicine-Tulsa OU-Tulsa

Nawajes Mandal, Ph.D.

Dean McGee Eye Institute Assistant Professor Department of Ophthalmology Adjunct Assistant Professor Departments of Cell Biology and Physiology College of Medicine Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center

Hiroyuki Matsumoto, Ph.D.

Professor Department of Biochemistry and Molecular Biology College of Medicine University of Oklahoma Health Sciences Center

Cynthia Muhamedagic, Ph.D.

Clinical Assistant Professor Department of Pediatrics College of Medicine Licensed Clinical Psychologist Behavioral Health Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center

Dean Myers, Ph.D.

John W. Records Chair in Maternal Fetal Medicine Professor Section of Maternal Fetal Medicine Department of Obstetrics and Gynecology College of Medicine University of Oklahoma Health Sciences Center

Tomoko Obara, Ph.D.

Assistant Professor of Cell Biology Department of Cell Biology College of Medicine University of Oklahoma Health Sciences Center

Ann Olson, Ph.D.

Professor Biochemistry and Molecular Biology Adjunct Professor Department of Pediatrics College of Medicine Assistant Dean Graduate College University of Oklahoma Health Sciences Center

Katherine Oâ&#x20AC;&#x2122;Neal, Pharm.D., M.B.A., B.C.A.C.P., C.D.E., B.C.-A.D.M., A.E.-C. Assistant Professor College of Pharmacy Adjunct Assistant Professor School of Community Medicine Department of Internal Medicine Director Internal Medicine Diabetes Education Program OU-Tulsa

Arthur Owora, Dr.P.H., M.P.H., C.P.H.

Research Biostatistician College of Pharmacy University of Oklahoma Health Sciences Center

Calin Prodan, M.D.

Professor Department of Neurology College of Medicine University of Oklahoma Health Sciences Center

Raju Rajala, Ph.D.

Dean McGee Eye Institute M.G. McCool Chair in Ophthalmology Professor Departments of Ophthalmology and Physiology Adjunct Professor Department of Cell Biology College of Medicine Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center

Bappaditya Ray, M.B.B.S., M.D.

Assistant Professor Director of Research Department of Neurology College of Medicine University of Oklahoma Health Sciences Center

H A ROL D H A M M DI A BET E S CE N T E R

MEMBERS, FACULTY, AND STAFF

Arlan Richardson, Ph.D.

Vinay Shah, M.D.

Erin Rubin, M.D.

Kevin Short, Ph.D.

Donald Reynolds Endowed Chair of Aging Research Professor Department of Geriatric Medicine College of Medicine University of Oklahoma Health Sciences Center

James Park Dewey Professorship Department of Pathology College of Medicine University of Oklahoma Health Sciences Center

Alicia Salvatore, Dr.P.H., MPH

Assistant Professor Department of Occupational and Environmental Health College of Public Health University of Oklahoma Health Sciences Center

Dharambir Sanghera, B.S., M.S., Ph.D., F.A.H.A.

Associate Professor Section of Genetics Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Deepa Sathyaseelan, Ph.D.

Research Assistant Member Free Radical Biology and Aging Research Program Oklahoma Medical Research Foundation

Christina Scifres, M.D.

Assistant Professor Section of Maternal Fetal Medicine Department of Obstetrics and Gynecology College of Medicine University of Oklahoma Health Sciences Center

Robert â&#x20AC;&#x153;Halâ&#x20AC;? Scofield, M.D.

Professor Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center Member, Arthritis and Clinical Immunology Program Oklahoma Medical Research Foundation Staff, Medical Service, Oklahoma City VA Medical Center

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Dean McGee Eye Institute Clinical Associate Professor Department of Ophthalmology College of Medicine University of Oklahoma Health Sciences Center

CMRI Choctaw Nation Chair in Pediatric Endocrinology Associate Professor Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Evgeny Sidorov, M.D., Ph.D.

Assistant Professor OUMC Comprehensive Stroke Center Medical Director Department of Neurology College of Medicine University of Oklahoma Health Sciences Center

Susan Sisson, Ph.D., R.D.N., C.H.E.S., F.A.C.S.M.

Assistant Professor Director, Behavioral Nutrition and Physical Activity Laboratory Department of Nutrition Sciences College of Allied Health University of Oklahoma Health Sciences Center

David Sparling, M.D., Ph.D.

Assistant Professor Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Kelly Standifer, Ph.D.

Professor and Chair Department of Pharmaceutical Sciences College of Pharmacy University of Oklahoma Health Sciences Center

David Stanford, Ph.D.

Assistant Professor of Research Department of Physiology College of Medicine University of Oklahoma Health Sciences Center

MEMBERS, FACULTY, AND STAFF

Zhongjie Sun, M.D., Ph.D.

Weidong Wang, Ph.D.

Luke Szweda, Ph.D.

Hille Family Foundation Chair Member and Chair Free Radical Biology and Aging Research Program Oklahoma Medical Research Foundation

Assistant Professor Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center

Yusuke Takahashi, Ph.D.

Yong Zhang, Ph.D.

Professor Department of Physiology College of Medicine University of Oklahoma Health Sciences Center

Assistant Professor of Research Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center

Takemi Tanaka, Ph.D.

Associate Professor Department of Pathology College of Medicine University of Oklahoma Health Sciences Center

Eleni Tolma, M.P.H., Ph.D.

Associate Professor Department of Health Promotion Sciences College of Public Health University of Oklahoma Health Sciences Center

James Tomasek, Ph.D.

Vice President for Research University of Oklahoma Health Sciences Center David Ross Boyd Professor Department of Cell Biology College of Medicine University of Oklahoma Health Sciences Center

Jeanie Tryggestad, M.D.

Assistant Professor Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

John Wenyu Wang, Ph.D.

Professor of Research Center of American Indian Health Research College of Public Health University of Oklahoma Health Sciences Center

Assistant Member Immunobiology and Cancer Research Program Oklahoma Medical Research Foundation

Jian Xu, B.S., M.S., Ph.D.

Research Assistant Professor Department of Pharmaceutical Sciences College of Pharmacy University of Oklahoma Health Sciences Center

Xin Zhang, M.D., Ph.D.

Professor Department of Physiology College of Medicine University of Oklahoma Health Sciences Center

ASSOCIATE MEMBERS Rebecca Allen, M.S., R.D./L.D., C.D.E.

Dietician, Diabetes Educator Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Dianne Brown, M.S., R.D.N., L.D., C.D.E.

Diabetes Educator Diabetes Education and Self-Management OU Physicians Diabetes Life Clinic Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center

Allison Campolo

Research Assistant Physiological Sciences Oklahoma State University

Melanie Cannon, M.A., B.S., R.N.

Clinical Research Coordinator Clinical Trials Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center

H A ROL D H A M M DI A BET E S CE N T E R

MEMBERS, FACULTY, AND STAFF

Catherine Carmichael

Regulatory Compliance Specialist Clinical Trials Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center

Jennifer Chadwick

Native American Programs Coordinator Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Michael Isaac, B.S., M.P.A., R.N.

Diabetes Educator Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Kaely Jackson, R.D./L.D.

Registered Dietician Maternal-Fetal Medicine OU Prenatal Diagnostic Center College of Medicine University of Oklahoma Health Sciences Center

Joane Less, R.N., B.S.N., M.B.A., C.C.R.C.

Clinical Research Nurse Coordinator II Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Christy Olson, M.S., R.D., L.D., C.D.E.

Diabetes Educator Diabetes Education and Self-Management OU Physicians Diabetes Life Clinic Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center

Wendy Ritchlin-Keller, A.A.S., C.M.A.

Medical Assistant and Patient Recruitment Specialist Clinical Trials and Prevention and Outreach Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center

Jennifer Salazar, M.P.H.

April Teague, M.S.

Research Associate Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Sally Westfall, M.S., R.N., C.D.E.

Diabetes Nurse Clinican Maternal-Fetal Medicine OU Prenatal Diagnostic Center College of Medicine University of Oklahoma Health Science Center

TRAINEE MEMBERS Aziz Ammara, M.B., B.S.

Fellow Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center

Qian Chen, M.S.

Doctoral Candidate Department of Physiology College of Medicine University of Oklahoma Health Sciences Center

Mei Du, M.S.

Doctoral Candidate Department of Physiology College of Medicine University of Oklahoma Health Sciences Center

Niran Hadad, B.Sc.

Graduate Student Oklahoma Center for Neuroscience College of Medicine University of Oklahoma Health Sciences Center

Shaoning Jiang, Ph.D.

Postdoctoral Fellow Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Clinical Research Coordinator I Clinical Trials Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center

2 015 A N N UA L R E P O R T

MEMBERS, FACULTY, AND STAFF

Lauren Labryer, M.D.

Fellow Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center

Sang-Min Lee, Ph.D.

Postdoctoral Research Fellow Department of Biochemistry and Molecular Biology College of Medicine University of Oklahoma Health Sciences Center

Ashley Martin, B.S.

Doctoral Candidate Department of Physiology College of Medicine University of Oklahoma Health Sciences Center

Zahra Maria, M.S.

Graduate Research Assistant Doctoral Candidate Department of Physiological Sciences Center for Veterinary Health Sciences Oklahoma State University

Dustin Masser, B.S.

Graduate Research Assistant Doctoral Candidate Department of Physiology College of Medicine University of Oklahoma Health Sciences Center

Jonathan Meyer, M.D.

Fellow Section of Diabetes and Endocrinology Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Bishwa Sapkota, Ph.D.

Research Associate Section of Genetics Department of Pediatrics College of Medicine University of Oklahoma Health Sciences Center

Ian Schalo, A.S., B.S.

Graduate Research Assistant Pharmaceutical Science Graduate College University of Oklahoma Health Sciences Center

Shanell Shoop, B.S.

Candidate for Masters Department of Biochemistry and Molecular Biology College of Agricultural Sciences and Natural Resources Oklahoma State University

Asitha Silva, M.S.

Doctoral Candidate Physiological Science Center for Veterinary Health Science Oklahoma State University

Mitali Talsania, M.D.

Fellow Section of Endocrinology, Metabolism, and Diabetes Department of Internal Medicine College of Medicine University of Oklahoma Health Sciences Center

EXECUTIVE COMMITTEE Blake T. Rambo, J.D., M.B.A. Chief Operating Officer Chairman, Executive Committee Harold Hamm Diabetes Center

Kenneth C. Copeland, M.D.

Director Harold Hamm Diabetes Center-Childrenâ&#x20AC;&#x2122;s

David H. Jelley, M.D.

Director Harold Hamm Diabetes Center-Tulsa

James T. Lane, M.D.

Director Harold Hamm Diabetes Center Adult Clinical Programs

Jian-xing Ma, M.D., Ph.D.

Director Harold Hamm Diabetes Center Research Programs

ADMINISTRATION Blake Rambo, J.D., M.B.A. Chief Operating Officer

Lance Leonard, M.B.A. Business Administrator

H A ROL D H A M M DI A BET E S CE N T E R

MEMBERS, FACULTY, AND STAFF

Administrative Manager

Patricia Parker

DIABETES EDUCATION AND SELF-MANAGEMENT

Andy Behrens

Christy Olson, M.S., R.D./L.D., C.D.E.

Lori Bowman, M.P.A.

Dianne Brown, M.S., R.D./L.D., C.D.E.

Assistant Director for Marketing

Development Officer

Katie Hoefling Staff Assistant

PATIENT EXPERIENCE & RESOURCE SERVICES Linda Nguyen

Patient and Family Services Representative

BEHAVIORAL HEALTH

Diabetes Educator

PREVENTION, OUTREACH AND HEALTHY LIFESTYLE PROGRAMS Molly Fernando, Psy.D. Clinical Psychologist

OU PHYSICIANS DIABETES LIFE CLINIC Karen Groff, M.S.N., R.N., B.C., C.N.L. Senior Clinic Administrator

Cynthia Muhamedagic, Ph.D.

April Brawdy

Molly Fernando, Psy.D

LaVeeta Williams

Clinical Psychologist

CLINICAL TRIALS AND TRANSLATIONAL RESEARCH

Clinic Manager

Patient Services Representative Team Lead

Jennifer Smith

Patient Services Representative

Cathy Carmichael Program Manager

OU PHYSICIANS DIABETES AND ENDOCRINOLOGY CLINIC

Jennifer Salazar, M.P.H.

Karen Groff, M.S.N., R.N., B.C., C.N.L.

Melanie Cannon, RN, MA

April Brawdy

Lead Clinical Research Coordinator

Clinical Research Coordinator

Wendy Ritchlin-Keller Medical Assistant

PEDIATRIC CAMP Heather Simmons, M.Ed., M.A. Program Manager

Senior Clinic Administrator

Clinic Manager

Londa Hollowell

APAC Manager

Melissa Oâ&#x20AC;&#x2122;Hagan, L.P.N.

Lead Licensed Practical Nurse

Romesha Fitzpatrick, M.A. Medical Assistant

Karlie Henderson

Patient Services Representative

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MEMBERS, FACULTY, AND STAFF

Dannah Raissannejad

Sarah Dawson, R.N., C.D.E.

Robyn Roberts

Keri Foote

Patient Services Representative

HAROLD HAMM DIABETES CENTER-CHILDRENâ&#x20AC;&#x2122;S OU PHYSICIANS DIABETES AND ENDOCRINOLOGY CLINIC

Pediatric Endocrine Nurse Specialist

Licensed Practical Nurse

Dana Gissandaner, B.S.

Patient Services Representative III

Jeanette Hollis

Patient Services Representative III

Rebecca Allen, M.S., R.D./L.D., C.D.E.

Michael Isaac, R.N.

Jennifer Campbell, R.N.

Stephan Larson, C.P.A.

Jennifer Chadwick, B.S.

Cassandra Jose

Natasha Chitsazan, R.D./L.D.

Kassidy King, R.N.

Kammi Clausen

Joane Less, R.N., .B.S.N., M.B.A., C.C.R.C.

LaTisha Davis

Kelle Dawn Overand, M.S., A.P.R.N., C.C.N.S-P., C.D.E.

Senior Diabetes Educator

Nurse Case Manager

Native American Programs Coordinator

Diabetes Educator

Patient Services Representative II

Patient Services Representative

Diabetes Educator

Business Manager

Medical Assistant

Clinic Nurse Manager

Senior Clinical Research Nurse Coordinator

Pediatric Clinical Nurse Specialist

Congratulations to our Dr. James Lane (center), recipient of the 2015 Legacy Award from the American Diabetes Association's Western Oklahoma Chapter. The Legacy Award is given to an individual whose impact on the diabetes epidemic is leaving a lasting legacy. The award was presented April 11 that the chapter's Legacy Gala in Downtown Oklahoma City. Pictured with Dr. Lane are Dr. Kenneth Copeland (left) and Dr. Joni Beck, both of Harold Hamm Diabetes Center-Children's. Dr. Lane is our director of adult clinical programs.

H A ROL D H A M M DI A BET E S CE N T E R

MEMBERS, FACULTY, AND STAFF

Jeff Preske, M.A.

Shari Stevens, R.N., C.D.E.

TODAY Study Program Coordinator

Diabetes Educator

Megan Short

Chris Loney BS, R.N.

Research Technician

Clinic Administrator

Sharon Silliman

Sharnella Goudeau, R.N.

Senior Administrative Assistant

Research Coordinator

Katy Duncan Hammond, M.S.

Holli Davenport, L.P.N.

Research Programs Coordinator

Licensed Practical Nurse

Stephanie Starry

Lourdes Escavar, L.P.N.

Staff Assistant and Fellowship Coordinator

Licensed Practical Nurse

April Teague, M.S.

Tracey Rowan

Research Associate and Lab Manager

Medical Assistant

Josefina Velasco

Kay Busenberg

Patient Services Representative III

Patient Service Representative

HAROLD HAMM DIABETES CENTER-TULSA

Kyle Dixon

Dana Greer, A.P.R.N., C.D.E.

Deborah Quarles

Nurse Practitioner

Patient Service Representative

Steve Ludiker, A.P.R.N., C.D.E.

Joyce Wallace

Nurse Practitioner

Patient Service Representative

Cathey Colburn, M.S., R.N., C.D.E.

CORE FACILITIES

Patient Service Representative

Lead Diabetes Educator

Diabetic Animal Core

Michelle Condren, P.harmD., C.D.E.

Jian-xing Ma, M.D., Ph.D.

Associate Professor

Core Facility Director

Diabetes Educator

Histology and Imaging Core

Amy Puls, R.D., L.D., C.D.E.

James J. Tomasek, Ph.D.

Diabetes Educator

Core Facility Director

2 015 A N N UA L R E P O R T

Active Grants Lipid Metabolism in the Retina

High-dose, mass practice intervention to reduce ADL

NEI/NIH R01. Anderson, RE (PI), Mandal, N (Co-

disability in dementia.

Inv). 12/1/2014 – 11/30/2018

Alzheimer’s Association. Ciro, C. (PI) 10/1/14- 9/30/16

Core Grant for Vision Research

Studies to Treat or Prevent Pediatric Type 2—

NIH/NEI. Anderson, R. (PI), Rajala, R. 09/01/11

TODAY Protocol

– 08/31/16

NIDDK/NIH. Copeland, K. 08/01/2015 – 04/30/2016

Second Messengers in Retina

Incentivizing Behavior: Promoting More Physical Activity

Presbyterian Health Foundation. Anderson R. (PI),

in American Indian Youth

Rajala, R. (Co-PI). 07/01/2015 – 06/30/2016

NIH/NCMHD. Henderson, Copeland, K. 06/01/2012

Point of Care Screening for Pediatric Cardiovascular Health

– 05/31/2017

Harold Hamm Diabetes Center. Blackett, P., Turner, P.,

TODAY Genetics

George, M. August 1, 2015- July 31, 2016

NIDDK/NIH DK02-005. Copeland, K. 03/01/2012 –

Metabolic roles of brain-derived neurotrophic factor in

02/28/2015

skeletal muscle

Oklahoma Shared Clinical and Translational

The Presbyterian Health Foundation. Chan, C.

Resources (OSCTR)

B. (PI) 2015-2016

NIH/NIGMS. James, Copeland, K. 09/01/2013 –

SH3 domain binding kinase 1 (SBK1) is a novel regulator

06/30/2018

of hepatic gluconeogenesis

Endocrine Long-Term Follow-up Contract

Harold Hamm Diabetes Center. Chan, C. B.

Oklahoma State Department of Health. Copeland, K.

(PI) 2015-2016

07/1/2011-06/30/2016

Studying the anti-obesity mechanism of BDNF mimetic

Type 1 Diabetes TrialNet

Oklahoma Center for the Advancement of Science &

NIDDK/NIH. Copeland, K. 10/01/2002 – 06/30/2016

Technology (OCAST). Chan, C. B. (PI) 2015-2018

Type 1 Diabetes Exchange

Mechanistic studies on obesity-deteriorated glucose and lipid

JAEB Center for Health Research. Copeland, K.

metabolisms

12/13/2010 – 03/31/2016

National Institute of Health (R01). Chan, C. B. (PI) 2013-2018

The Genetics and Neuroendocrinology of Short Stature International Study

Prenatal conditions and the pathway to obesity and diabetes

Lilly Research Laboratories. Copeland, K. 06/01/2000 –

in children

02/29/2016

NIH/NIDDK. (R01) Chernausek, S., Fields, D. 8/04/2010 – 5/31/2016 Short-term Outcomes of Interventions for Reproductive Dysfunction NIH/NICHD. Wisniewski, A., Chernausek, S. 7/1/2013 – 6/30/2018

American Norditropin Studies: Web-enabled Research (The ANSWER Program) Novo Nordisk. Copeland, K. 03/10/2003-09/17/2016 T1D Exchange Clinical Network Protocol JAEB Center for Health Research Copeland, K. 05/01/2013-04/30/2015

H A ROL D H A M M DI A BET E S CE N T E R

ACTIVE GRANTS

Test the latest advancements in Glucose Sensor Technology

Effect of the level of dietary protein on infant growth and

Medtronics. Copeland, K. 05/01/2015-01/31/2016

body composition in the first year of life – Three and five

An Analysis of Type 1 Diabetes Sensor-Augmented Insulin Pump Therapy Data

year growth and body composition follow-up Nestle. Fields, D. 08/24/2011 – 03/31/2015

Harold Hamm Diabetes Center. Davis, N (PI). 8/1/2015

Metabolic derangements in GDM offspring: Role for

– January 31, 2017.

breast-milk?

Claude Pepper Center Pilot Grant

Mead Johnson. Fields, D (PI). 06/01/2014-05/30/2016

Research Sub-Award from P30AG028718. Deak, F.

Maternal obesity, breast milk composition and

2015 – 2016

infant growth

Role of synaptic neurotransmission in Alzheimer’s disease Oklahoma Center for the Advancement of Science and Technology (OCAST). Deak, F (PI). 2013 – 2016 Altered neurotransmission in a novel model of brain aging and dementia College of Medicine Alumni Association’s (COMAA) College of Medicine Research Fund. Deak, F (PI). 2014– 2015

National Institutes of Health (NICHD). Fields, D (PI), Demerath E. 04/01/2014-03/31/2019 Acquisition of Shared High Performance Compute Cluster for Multidisciplinary Computational and DataIntensive Research National Science Foundation Major Research Instrumentation. Brunson (PI), Ford Versypt, A. 10/15 –9/18

Role of munc18 in synaptopathy as a novel mechanism of schizophrenia Presbyterian Health Foundation. Deak, F (PI). 2014 – 2015 Investigating the Mechanism of RBP4-Induced Endothelial Inflammation American Heart Association. Farjo, K (PI). 09/01/2013-06/30/2015 Defining the Role of RDH10 in Retinal Pigment Epithelium Oklahoma Center for the Advancement of Science and Technology. Farjo, K (PI). 10/01/2013-09/30/2016 Mentoring Diabetes Research in Oklahoma NIGMS (P20GM104934). Farjo, K (PJI). 01/01/2013–06/30/2017 Maternal transmission of dietary sugars through breast milk

Dr. Christina Scifres (left) and Dr. Madona

Harold Hamm Diabetes Center. Fields, D (PI).

Azar discuss plans for the Center for Diabetes in

04/01/2015-03/31/2016.

Pregnancy, a new partnership at OU Medicine made possible by an HHDC grant.

2 015 A N N UA L R E P O R T

ACTIVE GRANTS

Mathematical Modeling of Podocytes in Diabetic Kidney Disease Harold Hamm Diabetes Center. Ford Versypt, A (PI). 03/15 – 2/16 Insulin therapy-resistant epigenetic alterations in diabetic retinopathy NEI/NIH. Freeman, W (PI). 2011-2016 Oklahoma Nathan Shock Center of Excellence in the Biology of Aging NIA/NIH. Freeman, W (Co-PI). 2015-2020 Defective mitochondrial function & genomic maintenance with diabetic retinopathy NEI/NIH. Freeman, W (PI). 2015-2017 ALECARDIO study: Cardiovascular outcomes study to evaluate the potential of aleglitazar to reduce cardiovascular risk in patients with a recent acute coronary syndrome (ACS) event and type 2 diabetes mellitus (T2D) Roche. Thadani, U., Gosmanov N. 2011-2016

Dr. Mary Zoe Baker, a teaching physician in our Adult Diabetes and Endocrinology Clinic, received not one but two major honors this year

Dysfunctional PKA Signaling in the Diabetic Heart

for on-the-job excellence. The OU College of

Oklahoma Center for the Advancement of Science and

Medicine named her Stanton L. Young Master

Technology. Humphries, K (PI)

Teacher for 2015. As one of her nomination letters

Acetylation of Mitochondrial Proteins Increases ROS Production in the Diabetic Heart American Heart Association. Humphries, K (PI) Decreased Expression of Protein Kinase Inhibitor (PKI) in

noted, Dr. Baker “sets an amazing example that her students can only hope to emulate.” Perhaps not coincidentally, the College of Medicine’s Alumni Association honored her as 2015 Physician of the Year for Academic Medicine.

the Diabetic Heart Harold Hamm Diabetes Center. Humphries, K (PI). 2015-2016 Seed and Equipment Grants Presbyterian Health Foundation. Humphries, K (PI) Wound healing mechanisms modulated by novel antimicrobial peptide Oklahoma Center for the Advancement of Science and Technology (OCAST). Kasus-Jacobi, A (PI).

Identification of Membrane Receptors for CAP37 and CAP37-Derived Peptides University of Oklahoma Health Sciences Center College of Pharmacy Kasus-Jacobi, A (PI). 1/1/15 – 12/31/15 Autoimmune basis for postural tachycardia syndrome 1R56HL128393-01. Yu (PI), Kem, D (Co-Inv). 09/04/15 – 08/31/16

07/01/2015 – 06/30/2018

H A ROL D H A M M DI A BET E S CE N T E R

ACTIVE GRANTS

Diagnostic studies, Pathophysiology and treatment of

Following Treatment with MK-3102 in Subjects with Type

Orthostatic Tachycardia Syndrome

2 Diabetes Mellitus.

Dysautonomia Int. Kem, D (PI). 07/14/14 – 7/15/17

Merck Sharp & Dohme Corp. Lane, J (PI).

Pathophysiology of atria and ventricular

4/17/13 – 4/16/16

tachyarrhythmias and their relationship to autoantibodies

A long-term, randomized, double-blind, placebo-controlled,

activating the GPCR

multinational, multi-center, trial to evaluate cardiovascular

OU Foundation Webster Arrhythmia Research Fund.

and other long-term outcomes with semaglutide in subjects

Kem, D (PI). 06/01/14 – 05/30/2018

with type 2 diabetes.

Oklahoma Nathan Shock Center of Excellence in Basic

Novo Nordisk. Lane, J (PI). 3/5/13 – 3/4/16

Biology of Aging

A Phase 3, randomized, double-blind, placebo-controlled,

NIH. Richardson, A. PI., Kinter, M (PI). 1/1/15

26-week multicentre study with a 26 week extension to

– 12/31/15

evaluate the efficacy and safety of ertugliflozin monotherapy

A Novel Mechanism for Mitochondrial Regulation of Mammalian Longevity NIH. Van Remmen, H. (PI), Kinter, M (Co-Inv). 1/1/15 – 12/31/15 Chondrocyte Metabolic Stress in the Development of Osteoarthritis NIH. T. Griffin, T. PI., Kinter, M (Co-Inv). 1/1/15 – 12/31/15 LEADER – Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results – A Longterm, Multi-center, International, Randomized DoubleBlind, Placebo-controlled Trial to Determine Liraglutide

in the treatment of subjects with type 2 diabetes mellitus and inadequate glycemic control despite diet and exercise.” Merck/Pfizer. Lane, J (PI). 10/4/13 – 11/3/16 A trial comparing cardiovascular safety of insulin degludec versus insulin glargine in subjects with type 2 diabetes at high risk of cardiovascular events. Novo Nordisk. Lane, J (Sub-I). 11/4/13 – 5/4/2020 A randomized, double blind, cross-over trial comparing the safety and efficacy of insulin degludec and insulin glargine, both with insulin aspart as mealtime insulin in subjects with type 1 diabetes. Novo Nordisk. Lane, J (PI). 6/15/14 – 6/14/17

Effects on Cardiovascular Events.

A Phase 3 Randomized, Placebo Controlled, Blinded

Novo Nordisk. Lane, J (PI). 08/25/10 – 8/24/15

Study to Investigate the Safety and Efficacy of a Topical

A prospective, randomized, placebo-controlled, double-blind clinical trial to evaluate whether EGRIFTA® (tesamorelin for injection), 2 mg once daily SC, increases the risk of development or progression of diabetic retinopathy when administered to HIV-infected subjects with abdominal

Gentamicin-Collagen Sponge in Combination with Systemic Antibiotic Therapy in Diabetic Patients with an Infected Foot Ulcer. Innocoll Pharmaceuticals. Lane, J (PI). 7/29/15 – 5/31/16

lipohypertrophy and concomitant diabetes.

Safety and Efficacy of Human Regular U-500 Insulin

EMD Serono, Inc. Lane, J (PI). 1/29/13 – 1/28/16

Administered by Continuous Subcutaneous Insulin Infusion

A Randomized, Double-Blind, Placebo-Controlled,

versus Multiple Daily Injections in Subjects with Type 2

Multicenter Study to Assess Cardiovascular Outcomes

2 015 A N N UA L R E P O R T

ACTIVE GRANTS

Diabetes Mellitus: A Randomized, Open-Label, Parallel

Mentoring Diabetes Research in Oklahoma

Clinical Trial.

NIH COBRE/ Ma, J. (PI), Humphries, K (Project 1PI)

Eli Lilly and Company. Lane, J (PI). 10/01/15

9/10/12 – 6/30/17

– 12/01/16

A novel pathogenic mechanism for diabetic retinopathy

A Randomized, Multicountry, Multicenter, Double-

NIH R01. Ma, J. (PI), Takahashi (Co-Inv).

Blind, Parallel, Placebo-Controlled Study of the Effects

3/1/13 – 2/29/18

of Atrasentan on Renal Outcomes in Subjects with Type 2 Diabetes and Nephropathy. AbbVie Inc. Lane, J (PI). 10/01/15 – 10/01/17 Mechanism and treatment of atrophic AMD Oklahoma Center for the Advancement of Science and Technology. Le, Y (PI). 8/1/15 – 7/31/18 Study of RPE barrier NIH/NEI R01. Le, Y (PI). 09/01/10 – 8/31/15

The role of the wnt signaling pathway in choroidal neovascularization NIH R01. Ma, J (PI). 6/1/15 to 5/31/20 Pathogenic Role of Wnt Signaling in Diabetic Nephropathy Oklahoma Center for the Advancement of Science and Technology. Ma, J (PI). 10/1/13 – 9/30/16 A novel humanized antibody blocking the Wnt pathway for the treatment of diabetic retinopathy

Stem cell characteristics of Müller glia.

Juvenile Diabetes Research Foundation. Ma, J. (PI),

Oklahoma Center for Adult Stem Cell Research. Le, Y

Takahashi (Co-Inv). 8/1/14 – 7/31/16

(PI). 7/1/14 – 6/30/15 Therapeutics of geographic atrophy International Retinal Research Foundation. Le, Y (PI). 10/1/15 – 9/30/16 Pathobiology of retinal neurons Presbyterian Health Foundation. Le, Y (PI). 10/01/14-09/31/15 Mechanism of retinal degeneration Presbyterian Health Foundation. Le, Y (PI). 12/15/15-12/14/16 Mentoring diabetes research in Oklahoma NIH/NIGM/COBRE. Le, Y. (Early Career Investigator (ECI)-Project PI). 09/10/12-6/30/15

Sphingolipid Metabolism and Signaling in the Retina. NEI/NIH R01. Mandal, N (PI). 4/1/2012 – 3/31/2017 Sphingolipid signaling in corneal wound healing and fibrosis NEI/NIH. Mandal, N (Co-PI). 4/1/2015 – 3/31/2017 Protective Effects of FTY720 in Animal Models of Human Retinal Degeneration Foundation Fighting Blindness. Mandal, N (PI). 7/1/12 – 6/30/2017 RPB Ernest & Elizabeth Althouse Special Scholar Award Research to Prevent Blindness. Mandal, N (PI). 7/1/2013 – 6/30/2016 Pathogenesis and cure of obesity-related-glomerulopathy by omega-3

Immunobiology of EAU Recovery Through the

VPR Seed Grant. Obara (PI), Matsumoto, H (Co-Inv) “

Melanocortin-Adenosinergic Pathway

04/01/2014 – 03/31/2015

NIH/NEI R01. Lee, D (PI). 8/1/15 – 7/31/20

The Disease Proteomics and Gene Therapy Laboratory

The role of the wnt signaling pathway in choroidal

Kurume University Discretionary Research Fund.

neovascularization

Matsumoto, H. 04/01/2014-03/31/2019

NIH R01. Ma, J (PI). 8/1/11 – 7/31/15

H A ROL D H A M M DI A BET E S CE N T E R

ACTIVE GRANTS

Harold Hamm’s Director of Adult Clinical Programs, Dr. James Lane, fields a News 9 reporter’s questions in January 2015 about diabetes and obesity medications derived from a peptide found naturally, to the surprise of many, in the venom of the Gila monster, a North American reptile.

Mechanisms of Acclimatization: Fetus and Adult

Presbyterian Health Foundation. Rajala, R (PI).

NIH/NICHD. Longo, K, Myers, D (PI), Ducsay (PI).

10/01/14 – 09/30/15

6/01/10-5/31/15

Regulation of Retinal Cell Death in Diabetes

Impact of long term hypoxia during gestation on adipose

NIH/NEI. Gardner, TW (PI), Abcouwer SF (PI), Rajala,

function in the lamb

R. 09/01/2015 – 06/30/19

Presbyterian Health Foundation. Myers, D (PI). 10/1/14-9/30/15 Mechanism of maternal dietary imbalance and obesity on fetal and infant adiposity Presbyterian Health Foundation. Gunatilake, R, (PI), Myers, DA. 10/1/14-9/30/15 A literacy sensitive approach to improving antibiotic understanding in a community based setting. ACCP Ambulatory Care PRN, Tiller CM, O’Neal KS (PI), Miller MJ, Johnson JL, Lloyd AE. 11/1/14 – 11/30/15 Second Messengers in the Retina NIH/NEI. Rajala, R. (PI). 04/01/14 – 03/31/16

See, Test & Treat®, a one day free cervical and breast cancer screening and health fair American Pathologist Foundation. Rubin, E. 4/25/15 Comparison of Two Screening Strategies for Gestational Diabetes NIH R01. Davis (PI), Scifres, C. (Co-Inv), 9/25/14 – 5/31/19 The Impact of Maternal Obesity and Dietary Imbalance on Fetal and Infant Adiposity Presbyterian Health Foundation. Scifres, C. (PI). 1/1/15 – present Randomized Controlled Clinical Pilot Trial of Intensive Management of Gestational Diabetes

Light Activation of Retinal Insulin Receptor Signaling

College of Medicine Alumni Association. Scifres, C.

NIH/NEI R01 Rajala (PI). 09/01/10 – 08/31/15

(PI). 7/1/15 – present

Light Activation of Retinal Insulin Receptor Signaling

2 015 A N N UA L R E P O R T

ACTIVE GRANTS

Preventing Obesity in Young Children: Formative Development of Interdisciplinary Obesity Prevention Intervention for Early Childhood Infants, Toddlers, Twos and Threes. Sisson, S. (PI), Cheney, M., Jacob, A. 7/1/14 – 6/30/15 Assessing current status of nutrition and wellness components in child care centers participating in the CACFP National Food Service Management Institute. Sisson, S. (PI), Cheney, M. 4/1/15 – 3/30/16 Preschools, Parents and Physicians: Working Together to Curb Obesity in American Indian Children Presbyterian Health Foundation. Sisson, S. (PI), Horm, D., Cheney, M., Weedn, A., Stephens, L., Copeland, K. 7/1/15 – 6/30/16 A counselor and three of his campers take a

Single Cell Mitochondrial Heteroplasmy

break next to the go-kart track.

OCAST. Stanford, D. 2015-2018 Regulatory Role of MicroRNA-184 in Diabetic Retinopathy

Creation of the Center for Diabetes in Pregnancy Program Harold Hamm Diabetes Center. Scifres, C. (PI), Azar, M (Co-PI). 8/1/15 – present

OCAST. Takahashi (PI). 07/01/12 – 06/30/15 Fibroblast Differentiation in Wound Healing National Institutes of Health. Tomasek, J (PI).

Oklahoma Shared Clinical and Translational Resources

9/1/14 – 7/31/18

NIH/NIGMS. Scofield, H. 9/1/2013-9/31/2018

Mentoring Diabetes Researchers in Oklahoma

Incentivizing behavior: promoting more physical activity in American Indian youth NIH/NIMHS. Short, K. (PI). 6/1/12 – 5/31/17 Biomarkers of diabetes risk in children: role of obesity and exercise NIH/Mayo Clinic Metabolomics Resource Core. Short, K (PI). 6/1/15 – 5/31/16 Indirect calorimetry metabolic measurement system Presbyterian Health Foundation. Short, K. (PI). 7/1/15 – 6/30/16

National Institutes of Health. Tomasek, J. 9/15/07 – 6/30/17 Oklahoma Shared Clinical and Translational Resources National Institutes of Health. Tomasek, J. 9/1/13 – 6/31/18 The Studies to Treat or Prevent Pediatric Type 2 Diabetes—STOPP T2D NIDDK/NIH. Hirst, K (PI), Copeland, K. (Site PI), Tryggestad, J. (Site Co-Inv). 08/01/2015-04/30/2016 Oklahoma Shared Clinical and Translational Resources (OSCTR) NIH/NIGMS. Tryggestad, J. (PI). July 1, 2014 – June 30, 2015

H A ROL D H A M M DI A BET E S CE N T E R

ACTIVE GRANTS

Expanding Excellence in Developmental Biology in Oklahoma NIH/NIGMS. Thompson, L. (PI), Wang, W. (Co-PI). 3/1/13 – 2/28/18 Developing a New Version of TALEN Gene-editing Technology for Gene Therapy and Biomedical Research Oklahoma Center for the Advancement of Science and Technology. Wang, W (PI). 9/1/13 – 8/31/16 Discovering Small Molecules that Protect Beta Cells Against ER Stress-induced Death for Treatment of Diabetes Oklahoma Center for the Advancement of Science and Technology. Wang, W (PI). 9/1/13 – 8/31/15 Pancreatic Beta Cell Differentiation from Human IPS Cells Oklahoma Center for the Advancement of Science and Technology. Wang, W (PI). 7/1/12 – 6/30/15 Role of ULK1 in Diabetic Impairment of Angiogenesis Oklahoma Center of Advancement of Science and Technology. Xu, J (PI). 9/1/14 – 8/30/17 Role of endothelial autophagy in diabetes-induced angiogenesis impairment American Heart Association. Xu, J (PI). 7/01/14 – 6/30/16 How CD82 Restrains Neovascularization Potential American Heart Association Southwest Affiliate. Zhang, X (PI). 7/1/15 – 6/30/17 AMPK as a redox sensor and modulator NIH/NHLBI R01. Zou, M.H. (PI). 09/12/12-06/30/17 Interaction of Notch and Wnt pathway in diabetic retinopathy The Internationals Retinal Research Foundation. Zhang (PI). 11/01/12 – 4/30/15

2 015 A N N UA L R E P O R T

Publications Azar M, Stoner JA, Dung Dao H, Stephens L, Goodman

Gross C., Chang C., Kelly S.M., Bhattacharya

JR, Maynard J, Lyons TJ. Epidemiology of Dysglycemia

A., McBride S.M.J., Danielson S.W., Jiang M.Q.,

in Pregnant Oklahoma American Indian Women. J Clin

Chan C.B., Ye K., Gibson J.R., Klann E., Jongens T.A.,

Endoc Metab. 2015 Jun 19:jc20151779.

Moberg K.H., Huber K.M.& Bassell G.J. 2015 Increased expression of the PI3K enhancer PIKE mediates deficits

Beck, JK., Board Certification for Pediatric Pharmacy

in synaptic plasticity and behavior in Fragile X syndrome.

Specialist (BCPPS): Endocrine Review in Pediatric

Cell Reports 11: 727-736.

PharmPrep Advanced Guide (a mobile-prep workbook). Five, peer-reviewed, interactive internet endocrine

Chan C.B., Tse M.C.L, Liu X., Zhang S., Schmidt

learning modules (diabetes, obesity, adrenal insufficiency,

R., Otten R., Liu L. & Ye K. 2015 Activation of

thyroid disorders and short stature). Pediatric Pharmacy

Muscular TrkB by its Small Molecular Agonist

Advocacy Group. Published April 27, 2015, at http://ppagu.

7,8-Dihydroxyflavone Sex-dependently Regulates Energy

benchprep.com.

Metabolism in Diet-induced Obese Mice. Chemistry & Biology 22: 355-369.

Beck, JK., Cogan FR. Outpatient Management of Pediatric Type 1 Diabetes. J Pediatr Pharmacol Ther.

Chernausek SD, Arslanian S, Caprio S, Copeland KC,

2015;20(5):344-357.

El Ghormli L, Kelsey MM, Koontz MB, Orsi CM, Wilfley D. “Relationship Between Parental Diabetes

Beck, JK., Zhang, Y., Shay, CM., Muhamedagic, CA.,

and Presentation of Metabolic and Glycemic Funtion in

Sternlof SA., Ding, K., Short, MM., Dvorak, JD., Lane,

Youth with Type 2 Diabetes: Baseline Findings from the

JT., Diabetes Knowledge in Young Adults: Associations

TODAY Trial”. Diabetes Care. 2015 Nov 17. pii: dc151557.

With Hemoglobin A1C. Families, Systems, & Health.

[Epub ahead of print]

2015;33(1) 28-35. Ciro, C.A. and Smith, P.A. (2015) Improving Personal Beck, JK, Traficano, SE., Diabetes Educator Mentorship

Characterization of Meaningful Activity in Adults with

Program: Mentors Requested. Diabetes Educator

Chronic Conditions Living in a Low-Income Housing

2015;41(1):38-42.

Community. Special Issue: Occupational Therapies and Human Well Being. International Journal of

Blackett PR, Wilson DP, McNeal C. “Secondary

Environmental Research and Public Health. 12, 11379-

Hypertriglyceridemia in Children and Adolescents”. J

11395; doi:10.3390/ijerph120911379.

Clin Lipidol (5 Suppl):S29-40, 2015 Ciro, CA, Anderson, MP, Hershey, L, Prodan, C. Blackett PR, Aston, CE and Sanghera, DK. “Genetics

and Holm. M. (2015). A comparison of instrumental

of Cardiovascular Risk in Obesity”, Springer Meteor

activities of daily living and role satisfaction in people

January 2016

with and without mild cognitive impairment: A pilot project. American Journal of Occupational Therapy,

Wilson DP, Blackett PR, McNeal C. Dyslipidemia,

69, 6903270020p1-6903270020p10. doi:10.5014/

“Cardiovascular Disease, and Youth with Diabetes”. Lipid

ajot.2014.015198.

Spin (An Official Publication of the National Lipid Association). Special Issue 2015 66

H A ROL D H A M M DI A BET E S CE N T E R

Sometimes a short video says it best. Our professionally produced, two-minute introduction, "Together We Will," summarizes the major activity areas at Harold Hamm Diabetes Center and how they integrate into our mission. Explore our YouTube channel for this and other valuable video content. www.youtube.com/HaroldHammDiabetes

Zeitler P, Hirst K, Copeland KC, El Ghormli L, Levitt

Tarantini, S., P. Hertelendy, Z. Tucsek, M. N. Valcarcel-

KL, Levitsky LL, Linder B, McGuigan P, White NH,

Ares, N. Smith, A. Menyhart, E. Farkas, E. L. Hodges,

Wilfley D, TODAY Study Group. “HBA1c After a Short

R. Towner, F. Deak, W. E. Sonntag, A. Csiszar, Z.

Period Monotherapy with Metformin Identifies Durable

Ungvari and P. Toth (2015). “Pharmacologically-induced

Glycemic Control Among Adolescents with Type 2

neurovascular uncoupling is associated with cognitive

Diabetes”. Diabetes Care. 2015 Dec:38(12):2285-92. doi:

impairment in mice.” J Cereb Blood Flow Metab 35(11):

10.2337/dc15-0848. Epub 2015 Nov 4.

1871-1881. PMID: 26174328 10.1038/jcbfm.2015.162:10.1038/ jcbfm.2015.162.

Deak, F., W. M. Freeman, Z. Ungvari, A. Csiszar and W. E. Sonntag (2015). “Recent Developments in

Du M, Otalora L, Martin A, Moiseyev G,

Understanding Brain Aging: Implications for Alzheimer’s

Vanlandingham P, Wang Q, Yeganeh A, Farjo R,

Disease and Vascular Cognitive Impairment.” J Gerontol

Quiambao A, Farjo KM* (*corresponding author). (2015)

A Biol Sci Med Sci. PMID: 26590911 10.1093/gerona/

Transgenic mice over-expressing serum retinol-binding

glv206:10.1093/gerona/glv206.

protein develop progressive retinal degeneration through a retinoid-independent mechanism. Molecular and

Sevlever, D., F. Zou, L. Ma, S. Carrasquillo, M. G.

Cellular Biology, 35 (16):2771-89. PMID: 26055327

Crump, O. J. Culley, T. A. Hunter, G. D. Bisceglio, L. Younkin, M. Allen, M. M. Carrasquillo, S. B. Sando,

Alderete, T., C. Autran, B. Brekke, R. Knight, L.

J. O. Aasly, D. W. Dickson, N. R. Graff-Radford, R.

Bode, M. Goran and D. Fields (in press). Associations

C. Petersen, F. Deak, A. c. Kevin Morgan for and O.

between human milk oligosaccharides and infant body

Belbin (2015). “Genetically-controlled Vesicle-Associated

composition. AJCN.

Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility.”

Matias, C. P. Judice, D. Santos, J. Magalhaes, C.

Mol Neurodegener 10: 18. PMID: 25881291 10.1186/

Minderico, D. Fields, L. Sardinha and A. Silva (in press).

s13024-015-0015-x:10.1186/s13024-015-0015-x.

Suitability of bioelectrical based methods to assess water compartments in recreational and elite athletes. Journal of the American College of Nutrition.

2 015 A N N UA L R E P O R T

PUBLICATIONS

Ziegler, E., D. Fields, S. Chernausek, P. Steenhout,

J. C. Arciero, L. Ellwein, A. N. Ford Versypt, E.

D. Grathwohl, J. Jeter, S. Nelson and S. Hasche (in

Makrides, and A. T. Layton, “Modeling Blood Flow

press). Adequacy of infant formula with protein content

Control in the Kidney,” T. Jackson, A. Radunskaya

of 1.6g/100 kcal for infants between 3 and 12 months:

(eds.), Applications of Dynamical Systems in Biology and

A randomized multicenter trial. J Pediatr Gastroenterol

Medicine, The IMA Volumes in Mathematics and its

Nutr. [PMID: 26154030]

Applications 158, Springer, New York, 55–74, 2015.

Fields, D., A. Teague, K. Short and C. Chernausek (in

A. N. Ford Versypt, E. Makrides, J. C. Arciero, L.

press). Evaluation of DXA vs. MRI for body

Ellwein, and A. T. Layton, “Bifurcation Study of Blood

composition measures in 1-month olds. Pediatr Obes.

Flow Control in the Kidney,” Mathematical Biosciences,

[PMID: 25820269]

263, 169-179, 2015.

Fields, D., R. Gunatilake and E. Kalaitzoglou (in press).

Maa, A.Y., Feuer, W.J., Davis, C.Q., Pillow, E.K.,

Air displacement plethysmography: Cradle to Grave.

Brown, T.D., Caywood, R.M., Chasan, J.E. & Fransen,

Nutr Clin Pract. [PMID: 25886709]

S.R., A novel device for accurate and efficient testing for vision-threatening diabetic retinopathy, Journal of

Matias, C., D. Santos, J. Magalhaes, P. Judice, C.

Diabetes and Its Complications (2015), doi: 10.1016/j.

Minderico, D. Fields, H. Lukaski, L. Sardinha and

jdiacomp.2015.12.005

A. Silva (in press). Estimation of total body water and extracellular water with bio-impedance in athletes: a

Dozmorov MG, Adrianto I, Giles CB, Glass E, Glenn

need for athlete-specific prediction equations. Clinical

SB, Montgomery C, Sivils KL, Olson LE, Iwayama

Nutrition. [PMID: 25886709]

T, Freeman WM, Lessard CJ, Wren JD. Detrimental effects of duplicate reads and low complexity regions on

Pavela, G., H. Wiener, K. Fontaine, D. Fields, J. Voss

RNA- and ChIP-seq data. BMC Bioinformatics. 2015

and D. Allison (2015). Packet randomized experiments

Sep 25;16 Suppl 13:S10.

for eliminating classes of confounders. Eur J Clin Invest 45:45-55. [PMID: 25444088]

George, MM., Ruiz-Elizalde., AR, Beck, JK., “A Continuous Subcutaneous Insulin Infusion Needle

Lewis, D., D. Fields and D. Allison (in press).

Break”. Clin Diabetes. 2015 Oct;33 (4):195-7. doi: 10.2337/

Inconsistencies and inaccuracies in reporting on choice

diaclin.33.4.195. PMID: 26487795 [PubMed] PMCID:

of endpoints and of statistical results in RCT of maternal

PMC4608271 [Available on 2016-10-01]

diet. Pediatr Obes. [PMID: 25893663] Gosmanov, A., Gosmanov, N. Advancing clinical A. E. Lu, J. A. Paulson, N. J. Mozdzierz, A. Stockdale,

care for the patients with ketosis-prone diabetes:

A. N. Ford Versypt, K. J. Love, J. C. Love, and R. D.

from knowledge to action Journal of Diabetes and Its

Braatz, “Control Systems Technology in the Advanced

Complications 29 (2015) 853–854

Manufacturing of Biologic Drugs,” Proceedings of the IEEE Multi-Conference on Systems and Control, Sydney, Australia, 2015, In Press (Invited).

H A ROL D H A M M DI A BET E S CE N T E R

PUBLICATIONS

Matsuzaki, S., Humphries, K.M. Selective inhibition of

Brock AJ, Kasus-Jacobi A, Lerner M, Logan S, Adesina

deactivated complex I by biguanides. (2015) Biochemistry,

AM, et al. The antimicrobial protein, CAP37, is

54(11):2011-21.

upregulated in pyramidal neurons during Alzheimerâ&#x20AC;&#x2122;s disease Histochemistry and cell biology. 2015;

Bastian, A., Thorpe, J.E., Disch, B.C., Bailey-Downs,

144(4):293-308. PubMed [journal] PMID:26170148

L.C., Gangjee, A., Ziware, N., Henthorn, J., Humphries,

PMCID:PMC4575391

K.M., Vadvalkar, S.V., Inhat, M.A. A small molecule with anticancer and antimetastatic activities induces

Hongliang Li, David C. Kem*, Ling Zhang, Bing

rapid mitochondrial associated necrosis in breast cancer.

Huang, Campbell Liles, Alexandria Benbrook,

(2015) J. Pharmacol. Exp. Ther., 353: 392-404.

Hariprasad Gali, Vineet Veitla, Benjamin J. Scherlag, Madeleine W. Cunningham, Xichun Yu*. A Novel retro-

Fernandes J., Weddle A., Kinter C.S., Humphries K.M.,

inverso peptide inhibitor reverses angiotensin receptor

Mather T., Szweda L.I., and Kinter M. Lysine

autoantibodyâ&#x20AC;&#x201C;induced hypertension in the rabbit.

Acetylation Activates Mitochondrial Aconitase in the

Submitted to Hypertension. Hypertension 2015;65(4):793-

Heart. (2015) Biochemistry, 54 (25): 4008-4018.

799. PMID: 25691619; PMCID: PMC4359052

Griffin, T.M., Humphries, K.M., Kinter, M., Lim,

Galloway A, Li H, Vanderlinde-Wood M, Khan M,

H-Y., Szweda, L.I. Nutrient Sensing and Utilization:

Benbrook A, Liles C, Zillner C, Rao V, Cunningham

Getting to the Heart of Metabolic Flexibility (Review).

MW, Yu X, Kem DC. Activating autoantibodies to

(2015) Biochimie, (in press).

the B1/2-adrenergic and M2 muscarinic receptors associate with atrial tachyarrhythmias in patients

Bockus, L.B., Humphries, K.M. Dysfunctional cAMP-

with hyperthyroidism. Endocrine 2015;49(2):457-463.

dependent protein kinase (PKA) signaling causes an

PMID: 25500789

impaired adrenergic response in the diabetic heart. (2015) J. Biol. Chem., 290 (49): 29250-29258.

Li H, Kem DC, Zhang L, Huang B, Liles C, Benbrook A, Gali H, Veitla V, Scherlag BJ, Cunningham MW,

Jiang S, Park DW, Gao Y, Ravi S, Darley-Usmar V,

Yu X. Novel retro-inverso peptide inhibitor reverses

Abraham E, Zmijewski JW. Participation of proteasome-

angiotensin receptor autoantibody-induced hypertension

ubiquitin protein degradation in autophagy and the

in the rabbit. Hypertension 2015;65(4):793-799. PMID:

activation of AMP-activated protein kinase. Cell Signal.

25691619; PMCID: PMC4359052

2015 Jun;27(6):1186-97 Liles C, Li H, Veitla V, Liles JT, Murphy TA, Kasus-Jacobi A, Noor-Mohammadi S, Griffith GL,

Cunningham MW, Yu X, Kem DC. AT2R

Hinsley H, Mathias L, et al. A multifunctional peptide

autoantibodies block angiotensin II and AT1R

based on the neutrophil immune defense molecule,

autoantibody-induced vasoconstriction. Hypertension

CAP37, has antibacterial and wound-healing properties.

2015;66(4):830-835. PMCID: PMC4567423

Journal of leukocyte biology. 2015; 97(2):341-50. PubMed [journal] PMID:25412625 PMCID:PMC4304423

2 015 A N N UA L R E P O R T

PUBLICATIONS

Li H, Zhang L, Huang B, Veitla V, Scherlag BJ,

Tsutsui, Y., Johnson, J.M., Demeler, B., Kinter, M.,

Cunningham MW, Aston CE, Kem DC, Yu X. A

Hays, F.A. (2015) Conformation-dependent human

peptidomimetic inhibitor suppresses the inducibility

p52Shc phosphorylation by human c-Src. Biochemistry.

of b1-adrenergic autoantibody-mediated cardiac

54:3469-3482.

arrhythmias in the rabbit. J Interv Card Electrophysiol in press (DOI: 10.1007/s10840-015-0063-8)

Lane, R.S., Fu, Y., Matsuzaki, S., Kinter, M., Humphries, K.M., Griffin, T.M. (2015) Mitochondrial

Hongliang Li, Taylor Murphy, Ling Zhang, Bing Huang,

respiration and redox coupling in articular chondrocytes.

Vineet Veitla, Benjamin J. Scherlag, David C. Kem,

Arthritis Res Ther. 17:54.

and Xichun Yu, B1-adrenergic and M2 Muscarinic Autoantibodies and Thyroid Hormone Facilitate

Wong, K.E., Mikus, C.R., Slentz, D.H., Seiler, S.E.,

Induction of Atrial Fibrillation in Male Rabbits.

DeBalsi, K.L., Ilkayeva, O.R., Crain, K.I., Kinter, M.,

Endocrinology In Press DOI: 10.1210/en.2015-1655

Kien, C.L., Stevens, R.D., Muoio, D.M. (2015) MuscleSpecific overexpression of PGC-1α does not augment

Walsh, M.E., Bhattacharya, A., Sataranatarajan, K.,

metabolic improvements in response to exercise and

Qaisar, R., Sloane, L., Rahman, M.M., Kinter, M., Van

caloric restriction. Diabetes. 64:1532-1543

Remmen, H. (2015) The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle

Krishnan, S., Wisniewski AB. Ambiguous genitalia in

atrophy during aging. Aging Cell. 14: 957-970.

the newborn. IN Endotext. PMID: 25905391 Kurien BT, Danda D, Scofield RH. Therapeutic potential of curcumin and curcumin analogues in rheumatology. Int J Rheum Dis. 2015;18:591-3.

Watch a recorded chat titled “Diabetes and You” with Dr. Kenneth Copeland (right), director of Harold Hamm-Children’s. The in-depth, 33-minute interview is part of the weekly series of OU Medicine Chats, whose archives can be viewed free of charge. www.ustream.tv/recorded/77614423

H A ROL D H A M M DI A BET E S CE N T E R

PUBLICATIONS

Kabeerdoss J, Kurien BT, Ganapati A, Danda

Biswal M.R., Idelfonso C., Mao H., Seo S.J., Wang Z.,

D. Proteomics in rheumatology. Int J Rheum Dis.

Li H., Le Y, Lewin AS. (2016) Conditional Induction of

2015;18:815-7.

Oxidative Stress in RPE: a Mouse Model of Progressive Retinal Degeneration. Adv Exp Med Biol. 854:31-7.

Western blotting: Methods and Protocols. Eds. Kurien BT, Scofield RH. Methods in Molecular Biology

Grabner C., Gandini M., Rehak R., Le Y., Zamponi

Series, Humana Press/Springer Science, New York, NY.

GW., Schmitz, F. (2016) RIM1/2 Mediated Facilitation

1312, June 2015.

of Cav1.4 Channel Opening is Required for Ca2+Stimulated Release in Mouse Rod Photoreceptors. J.

Detection of blotted proteins: Methods and Protocols.

Neurosci. (In press).

Eds. Kurien BT, Scofield RH. Methods in Molecular Biology Series, Humana Press/Springer Science, New

Li L, Rao KN, Le Y, Hurd TW, Lillo C, Khanna H

York, NY, Vol. 1314, 2015.

(2016) Loss of Retinitis Pigmentosa 2 (RP2) protein affects cone photoreceptor sensory cilium elongation in

Fu S, Dong, S, Zhu M, Sherry DM, Wang Y, You Z

mice. Cytoskeleton (In press

Haigh JJ, Le Y (2015) Müller glia are a major cellular source of survival signals for retinal neurons in diabetes.

Lee DJ, Taylor AW. (2015) Recovery from experimental

Diabetes 64(10):3554-63.

autoimmune uveitis promotes induction of anti-uveitic

Perusek L, Sahu B, Parmar T, Maeno H, Aria E, Le Y,

Jun;97(6):1101-9. PMID: 25877928.

inducible Treg. Journal of Leukocyte Biology. 2015 Subauste C, Chen Y, Palczewski K, Maeda A (2015) A2E accumulation and visual function are independent

Hu, S., Liu, H., Ha, Y., Luo, X., Motamedi, M.,

of Atg7-mediated autophagy in the retinal pigmented

Gupta, M.P., Ma, J-x., Tilton, R.G., Zhang, W. (2015)

epithelium. J. Biol. Chem. (290(48):29035-44. doi:

Posttranslational Modification of Sirt6 Activity

10.1074/jbc.M115.682310.

by Peroxynitrite. Free Radical Biology & Medicine, 79, 176-185.

Wang J., Zhu M., Le Y. (2015) Müller cell-derived VEGF in diabetic retinopathy. World J. Diabetes. 6 (5):726-33.

Wang, Z., Cheng, R., Lee, K., Puneet, T., Ding, L.,

doi: 10.4239/wjd.v6.i5.726.

Kompella3, U.B., Chen, J., Xu, X. Ma, J-x. (2015) Nanoparticle-Mediated Expression of a Wnt Pathway

Ma S, Venkatesh A, Langellotto F, Le Y, Hall MN,

Inhibitor Ameliorates Ocular Neovascularization.

Rüegg MA, Punzo C. (2015) Loss of mTOR signaling

Arteriosclerosis, Thrombosis and Vascular Biology, 35:855-

affects cone function, cone structure and expression of

864. PMID:25657312

cone specific proteins without affecting cone survival. Exp Eye Res. 135:1-13. PMC4446177

Takahashi, Y., Chen, Q., Rajala, R.V.S., Ma, J-x. (2015) MicroRNA-184 modulate canonical Wnt signaling

Le Y, Zhu M, Anderson, RE (2016) Cre recombinase:

through the regulation of frizzled-7 expression in the

you can’t live with it, and you can’t live without it. Adv

retina with ischemia-induced neovascularization. FEBS

Exp Med Biol. 854:725-30.

Lett. In press.

2 015 A N N UA L R E P O R T

PUBLICATIONS

Tuo, J., Wang, Y., Cheng, R., Li3, Y., Chen, M., Qiu, F.,

Matsumoto, H., T. Iwasa, T. Yoshizawa 2015. Role of

Qian, H., Shen, D., Penalva, R., Xu, H., Ma, J-x. and

Non-covalent β-Ionone-ring Binding Site in Rhodopsin:

Chan, C-C. (2015) Wnt signaling in age-related macular

Historical and Physiological Perspective. Photochemical

degeneration: human macular tissue and mouse model. J.

and Photobiological Sciences, Advance Article,

Translational Med. In press.

July 28, 2015.

Stiles M, Moiseyev GP, Eckerd A, Brush RS, Budda

Myers DA, Singleton K, Kenkel C, Kaushal KM,

ML, White GL, Wolf RF, Ma J., Floyd R, Anderson RE,

Ducsay CA. Gestational hypoxia modulates expression of

Mandal NA (2015). PBN (phenyl-N-tert-butylnitrone)-

corticotropin releasing hormone and arginine vasopressin

derivatives are effective in slowing the visual cycle and

in the hypothalamic paraventricular nucleus in the ovine

rhodopsin regeneration and in protecting the retina from

fetus. Physiological Reports. “In Press” awaiting e-Pub.

light-induced damage. Accepted in Plos One. Jackson D, Deschamps D, Myers D, Fields D, Knudtson Marin, M., Tryggestad, JB., Aston, C., Teague, AM.,

E, Gunatilake R. Fetal epicardial fat thickness in

Dasari, PS., Short, KR “Oxidized HDL and LDL

diabetic and non-diabetic pregnancies: a retrospective

in Adolescents With Type 2 Diabetes Compared to

cross sectional study. Obesity. In press.

Normal Weight and Obese Peers.” Journal of Diabetes and Its Complications, 29:679-685, 2015. PMID: 25881918

Newby EA, Myers DA, Ducsay CA. 2015. Fetal

Accepted Mar 5, 2015

endocrine and metabolic adaptations to hypoxia:

Marin MT, Coffey ML, Beck JK, Dasari PS, Allen RA,

Am. J. Physiol. Endocrinol. Metab. 309:E429-39.

Krishnan S. “A Novel Approach to the Management

PMID: 26173460

the role of the hypothalamic-pituitary-adrenal axis.

of Neonatal Diabetes Using Sensor-Augmented Insulin Pump Therapy With Threshold Suspend Technology at

Newby EA, Kashal KM, Myers DA, Ducsay CA.

Diagnosis”. Diabetes Spectrum; Accepted.

2015. ACTH and PI3K/Akt inhibition reduce eNOS phosphorylation and increase cortisol biosynthesis in

Masser DR, Stanford DR, Freeman WM. Targeted

long term hypoxic ovine fetal adrenal cells. Reprod.

DNA Methylation analysis by next generation

Sciences 22:932-41. PMID: 25656500

sequencing. JoVE, 2015 96:24. Myers DA, Singleton K, Hyatt K, Mlynarczyk M, Haniu, H., Watanabe, Kawashima, Y., Matsumoto, H.

Kaushal K, Ducsay DA. 2015. Long term gestational

2015. Two-dimensional gel-based protein standardization

hypoxia modulates expression of key genes governing

verified by western blot analysis. (Kurien, B.T., Scofield,

mitochondrial function and biogenesis in the perirenal

R.H., eds.) Western Blots: Methods and Protocols. Methods

adipose of the late gestation sheep fetus. Reprod.

in Molecular Biology, 1312:473-479., Springer, New York.

Sciences 22:654-663. PMID: 25504105 O’Neal KS, Johnson JL, Swar S. Nontraditional considerations with insulin needle length selection. Diabetes Spectrum. 2015; 28(4):264-267.

H A ROL D H A M M DI A BET E S CE N T E R

PUBLICATIONS

Downes JM, O’Neal KS, Johnson, JL, Miller, MJ,

Demetris AJ, Crawford JM, Isse K, Minervini MI,

Honey BL, Weisz MA. Identifying opportunities to

Nalesnik MA, Rubin E, Randhawa PS, Sasatomi

improve medication therapy management in transitions

E: Pathology of Liver and Hematopoietic Stem Cell

of care. Am J Health Syst Pharm 2015;72(Supp 2):S58-S69.

Transplantation. In: Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas 3e (Eds. Robert Odze,

Murray KA, O’Neal KS, Weisz MA. Dietary suggestions

John Goldblum), Saunders, Philadelphia, 2015, pp

for migraine prevention. Am J Health Syst Pharm

1408-1461.

2015;72(7):519-21. Sanghera DK, Blackett PR. “Vitamin D Status, Weinstock RS, Trief PM, El Ghormli L., Goland R,

Genetics, and Diabetes Risk Springer”, Elsevier,

McKay S, Milaszewski,K, Preske J, Willi, S, Yasuda, PM,

Chapter 26. 2015

“Parental Characteristics Associated With Outcomes in Youth With Type 2 Diabetes: Results From the TODAY

Sapkota, B, Subramanian, A, Priamvada, G., Finely, H,

Clinical Trial”. Diabetes Care 2015 Mar 17 pii: dc142393.

Blackett, P and Sanghera, DK. “Association of APOE Polymorphisms with Diabetes and Cardiometabolic Risk

Wang Y, Rajala A and Rajala RVS (2015) Lipid

Factors and the Role of APOE Genotypes in Response

nanoparticles for ocular gene therapy. J Funct Biomater

to Anti-diabetic Therapy: Results from the AIDHS/SDS

6: 379-394.

on a South Asian Population” accepted for publication, Journal of Diabetes and Its Complications 2015.

Rajala RVS, Bishop M, Wang Y, Rajala A and Anderson RE (2015). The p110α isoform of

Sapkota B, Hopkins R, Bjonnes A, Ralhan S, Wander

phosphoinositide 3-kinase is essential for cone

GS, Mehra NK, Singh JR, Blackett P, Saxena R,

photoreceptor survival. Biochimie, 112-35-40.

Sanghera DK. Genome-wide Association Study of 25(OH) Vitamin D Concentrations in Punjabi Sikhs:

Woodruff ML, Rajala A, Fain GL and Rajala RVS (2015)

Results of the Asian Indian Diabetic Heart Study The

Effect of knocking down the insulin receptor on mouse

Journal of Steroid Biochemistry and Molecular Biology

rod responses. Scientific Reports, 5: 7858.

(Accepted Dec 11, 2015).

Gupta VK, Rajala A and Rajala RVS (2015) Non-

Sandhya P, Jeyaseelan L, Scofield RH, Danda

canonical regulation of phosphatidylinositol 3-kinase

D. Clinical Characteristics and Outcome of

gamma isoform activity in retinal rod photoreceptor cells.

Primary Sjogren’s Syndrome: A Large Asian Indian

Cell Commination and Signaling,13:7.

Cohort. Open Rheumatol J 26:9:36-45, 2015 Jun. (PMCID:PMC4493630) Scifres CM, Abebe KZ, Jones KA, Comer DM, Costacou T, Freiberg MS, Simhan HN, Day NL, Davis EM. Gestational Diabetes Diagnostic Methods (GD2M) Pilot Randomized Trial. Maternal Child Health Journal 2015;19:1472-80.

2 015 A N N UA L R E P O R T

PUBLICATIONS

Catov JM, Peng Y, Scifres CM, Parks WT. Placental

Irving BA, RE Carter, M Soop, A Weymiller, H Syed,

pathology measures: can they be rapidly and reliably

H Karakelides, S Bhagra, KR Short, L Tatpati, R

integrated into large-scale perinatal studies? Placenta

Barazzoni, KS Nair. Effect of insulin sensitizer therapy

2015;36:687-92.

on amino acids and their metabolites. Metabolism, 64: 720-728, 2015. PMID: 25733201

Scifres CM, Feghali M, Althouse AD, Caritis SN, Catov JM. Adverse Outcomes and Potential Targets

Short KR, AM Teague, DA Fields, T Lyons,

for Intervention in Gestational Diabetes and Obesity.

SD Chernausek. Lower resting energy expenditure and

Obstetrics and Gynecology 2015;126:316-25 .

fat oxidation in Native American and Hispanic infants born to mothers with diabetes. J Pediatr 166: 884-889,

Scifres CM, Feghali M, Dumont T, Althouse AD, Speer

2015. PMID: 25648295; PMCID: PMC4380761

P, Caritis SN, Catov JM. Large-for-Gestational Age Ultrasound Diangosis and Risk for Cesarean Delivery in

Lora, K.R., Branscum, P., Sisson, S.B., Scott, L.M.,

Women With Gestational Diabetes Mellitus. Obstetrics

Anderson, M., Knehans, A.W. Relationship of Food

and Gynecology 2015;126:978-86.

Label Use and Household Availability of Beverages in a Sample of Mothers of Preschool Children Participating

Walgama J, Elshatory YM, Shah VA. Ophthalmomyiasis:

in the Supplemental Nutrition Assistance Program.

a lit path. JAMA

American Journal of Health Studies, in press.

Ophthalmol. 2015 Feb;133(2):e143474. doi: 10.1001/ jamaophthalmol.2014.3474. Epub 2015 Feb 12. PubMed

Rasbold, A.H., Sisson, S.B., Lora, K.R., Mitchell,

PMID: 25674897.

C.M.Television Access, Obesity and Dietary Consumption Among Oklahoma Preschool Age

Elshatory YM, Shah VA. Bead block embolization of a

Children. Advances in Pediatric Research, in press.

retinal arteriole. JAMA Ophthalmol. 2015 Feb;133(2):156. doi: 10.1001/

Rasbold, A.H., Adamiec, R., Anderson, M.P., Horm, D.,

jamaophthalmol.2014.616. PubMed

Campbell, J.E., Sitton, L.K., Sisson, S.B. Macronutrient

PMID: 25502278

and Micronutrient Intake of Children in Oklahoma Child Care Centers. Public Health Nutrition, in press.

Kim LA, Wong LL, Amarnani DS, Bigger-Allen AA,

PMID: 26278280

Hu Y, Marko CK, Eliott D, Shah VA, McGuone D, Stemmer-Rachamimov AO, Gai X, Dâ&#x20AC;&#x2122;Amore

Swyden, K., Sisson, S.B., Sheffield-Morris, A., Copeland,

PA, Arboleda-Velasquez JF. Characterization of cells

K., Lora, K., Weedn, A., DeGrace, B. Relationship

from patient-derived fibrovascular membranes in

between parental concern and perception of child weight

proliferativediabetic retinopathy. Mol Vis. 2015 Jun

and obesogenic parenting practices. (2015). Advances in

12;21:673-87. eCollection

Pediatric Research, 2(12) 1-9. PMID: None

H A ROL D H A M M DI A BET E S CE N T E R

PUBLICATIONS

Dennison, M., Sisson, S.B., Stephens, L., Lora, K.,

Tryggestad JB, Wang JJ, Zhang SX, Thompson

Caudillo, C., Copeland, K., Assessment of Sugar

DM, Short KR. Elevated plasma pigment epithelium-

Sweetened Beverage Intake, Physical Activity Behaviors

derived factor in children with type 2 diabetes mellitus

and Body Mass Index of American Indian Children

is attributable to obesity. Pediatr Diabetes. 2015

in Rural and Urban Oklahoma. (2015). Journal of

Dec;16(8):600-5. PubMed PMID: 25293868.

Community Health , in press. PMID: 25750107 Walders-Abramson N, Anderson B, Larkin ME, Chang DeGrace, B.W., Foust, R.E., Sisson, S.B., Lora,

N, Venditti E, Bzdick S, Tryggestad JB, Tan K, Geffner

K.R. The Benefits of Family Meals for Children with

ME, Hirst K. Benefits and barriers to participating in

Disabilities. (2015). American Journal of Occupational

longitudinal research of youth-onset type 2 diabetes:

Therapy, in press. PMID: None

Results from the TODAY retention survey. Clin Trials. 2015 Nov 3. pii: 1740774515613949. [Epub ahead of

Sparling DP, Yu J, Kim K, Zhu C, Brachs S, Birkenfeld

print] PubMed PMID: 26531295. Marin MT, Dasari PS,

AL, Pajvani UB, Adipocyte-specific blockade of gamma-

Tryggestad JB, Aston CE,

secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity, Molecular Metabolism (2016),

Tryggestad JB, Willi SM. Complications and

doi: 10.1016/j.molmet.2015.11.006.

comorbidities of T2DM in adolescents: findings from the TODAY clinical trial. J Diabetes Complications. 2015

Mangold CA, Masser DR, Stanford DR, Bixler GV,

Mar;29(2):307-12. PubMed PMID: 25468310; NIHMSID:

Pisupati A, Giles CB, Wren JD, Ford MM, Sonntag

NIHMS642097; PubMed Central PMCID: PMC4333013.

WE, Freeman WM. CNS-wide Sexually Dimorphic Induction of Major Histocompatibility Complex 1

Duan H, Li Y, Lim HY, Wang W. Identification of

Pathway with Aging. J Gerontology: Biol Sci, 2016

5-nitrofuran-2-amide derivatives that induce apoptosis

(in press).

in triple negative breast cancer cells by activating C/ EBP-homologous protein expression. Bioorganic

Takahashi, Y., Chen, Q., Rajala, R. and Ma, J..,

and Medicinal Chemistry. 2015 Aug 1;23(15):4514-

MicroRNA-184 modulates canonical Wnt signaling

21. doi: 10.1016/j.bmc.2015.06.011. Epub 2015 Jun 14.

through the regulation of frizzled-7 expression in the

PMID:26116180.

retina with ischemia-induced neovascularization., FEBS Lett., 2015, 589, 1143-1149, (*Corresponding author).

Zhang H, Wang X, Lv K, Gao S, Wang G, Fan C, X. A. Zhang, Yan J. 2015. Time Point-based Integrative

Teague AM, Fields DA, Aston CE, Short KR,

Analyses of Deep-transcriptome Identify Four Signal

Lyons TJ, Chernausek SD. Cord blood adipokines,

Pathways in Blastemal Regeneration of Zebrafish Lower

neonatal anthropometrics and postnatal growth in

Jaw. Stem Cells. 33:806-818.

offspring of Hispanic and Native American women with diabetes mellitus. Reproductive Biol Endocrinol, 13: 68,

Huang C, Dai JX, and X. A. Zhang. 2015.

2015. PMID: 26111704; PMCID: PMC4482040

Environmental Physical Cues Determine the Lineage Specification of Mesenchymal Stem Cells. Biochim Biophys Acta. 1850:1261-1266.

2 015 A N N UA L R E P O R T

Our Locations

Harold Hamm Diabetes Center 1000 North Lincoln Boulevard Oklahoma City, OK 73104 (405) 271-7000

Harold Hamm Diabetes Center – Children’s OU Children’s Physicians Building 1200 North Children’s (aka Phillips) Avenue, Suite 4500 Oklahoma City, OK 73104 (405) 271-3303

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H A ROL D H A M M DI A BET E S CE N T E R

2015 Annual Report University of Oklahoma Board of Regents Jon R. Stuart Chairman

A. Max Weitzenhoffer Vice Chairman

Clayton I. Bennett Kirk D. Humphreys Leslie J. Rainbolt-Forbes, M.D. Bill W. Burgess, Jr. C. Renzi Stone

University Administration David L. Boren President, University of Oklahoma

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CONTRIBUTORS Katie Hoefling Staff Assistant & Membership Coordinator Lori Neal Bowman Development Officer Theresa Green Communications Specialist, UHAT

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PHOTOGRAPHY Andy Behrens McNeese Stills + Motion Allen Peters Reflections Photography Aaron Snow

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Harold Hamm Diabetes Center Executive Committee

This publication, printed by University Printing Services,

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the State of Oklahoma.

Chief Operating Officer, Chairman, Executive Committee, Harold Hamm Diabetes Center

Kenneth C. Copeland, M.D.

is issued by the Harold Hamm Diabetes Center at the University of Oklahoma. 660 copies have been prepared and distributed at no cost to the taxpayers of

The University of Oklahoma, in compliance with all applicable federal and state laws and regulations does not discriminate on the basis of race, color, national

Director, Harold Hamm Diabetes Center–Children’s

origin, sex, sexual orientation, genetic information,

David H. Jelley, M.D.

disability, political beliefs, or status as a veteran

Director, Harold Hamm Diabetes Center–Tulsa

in any of its policies, practices, or procedures. This

James T. Lane, M.D.

financial aid, and educational services.

Director, Harold Hamm Diabetes Center–Adult Clinical Programs

gender identity, gender expression, age, religion,

includes, but is not limited to: admissions, employment,

For questions regarding discrimination, sexual assault, sexual misconduct, or sexual harassment, please

Jian-xing Ma, M.D., Ph.D.

contact the Office(s) of Institutional Equity as maybe

Director, Harold Hamm Diabetes Center–Research Programs

applicable: Norman campus at (405) 325-3546/3549, the Health Sciences Center at (405) 271-2110, or the OU-Tulsa Title IX Office at (918) 660-3107. Please see www.ou.edu/eoo.

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Our 2015 Report includes: Why the diabetes epidemic can’t be ignored, how the center’s work saves lives and makes a difference, and how you can help! Be a Partner for Progress or make a gift – see inside back cover for details.