NOVEMBER 2012
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VOLUME 11, ISSUE NUMBER 11
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www.renalandurologynews.com
PCa Recurrence Linked to Hypertension
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Moderately and severely obese patients also have a twofold increased risk, new study finds
HYPERTENSION IN MEN after PCa surgery raises their PSA failure risk by 51%.
BY JODY A. CHARNOW HYPERTENSION MAY be a novel independent risk factor for the biochemical recurrence of prostate cancer (PCa) after radical prostatectomy, a new study suggests. The study also confirmed previous research showing that obesity increases the risk. Of 1,428 men who underwent RP, 107 (8%) experienced biochemical recurrence after a median follow-up period of 3.6 years. Hypertension and obesity were associated with a significant 51% and 37% increased risk of biochemical recurrence, respectively, after adjusting for age, surgical margin status, tumor stage, Gleason score, and metabolic syndrome features, researchers reported online ahead of print in
Laser Prostatectomy Use On the Rise COPD Raises LASER PROSTATECTOMY use has in Ann Arbor identified 54,399 TURP Dialysis Patient increased substantially as a treatment and 29,457 laser prostatectomy procefor benign prostatic hyperplasia (BPH) dures that took place during the study at the expense of transurethral resection period (2001 to 2009). Although the Death Risk of the prostate (TURP), a study found. Using the Florida State Inpatient Database and Ambulatory Surgery Database, Florian R. Schroeck, MD, and colleagues at the University of Michigan
CME FEATURE
overall rates of transurethral surgery for BPH remained stable during the study period at 248/100,000 men in 2001 and 233 per 100,000 men in 2009, laser proscontinued on page 10
Earn 1 CME credit in this issue
Nonmuscle Invasive Bladder Cancer: Guidelines for Treatment PAGE 38
BY JODY A. CHARNOW CHRONIC OBSTRUCTIVE pulmonary disease (COPD) in patients starting dialysis increases their mortality risk and decreases their likelihood of receiving a kidney transplant, especially in current smokers, according to researchers. Austin G. Stack, MD, of the University of Limerick Graduate Entry Medical School in Ireland, and colleagues analyzed data on 769,984 U.S. dialysis patients who commenced dialysis between May 1995 and December 2004. Of these, 7.5% had COPD. After adjusting for potential confounders, patients with COPD had a 20% increased risk of death compared with those who did not have COPD, the researchers reported in the American Journal of Nephrology (2012;36:287-295). The risk was increased by 28% for patients who had COPD and also smoked. In addition, in adjusted analyses, nonsmokers with COPD had a 46% continued on page 10
Prostate Cancer and Prostatic Disease. The presence of both conditions was associated with a significant twofold increased risk. The investigators, led by Ramsey Asmar, MD, of the University of Michigan Medical School and Comprehensive Cancer Center in Ann Arbor, noted that their finding of a link between obesity and PCa biochemical recurrence is consistent with a previous study led by Stephen J. Freedland, MD, then at Johns Hopkins University School of Medicine in Baltimore, but now at Duke University Medical Center in Durham, N.C. The study by Dr. Freedland and his colleagues showed that moderately and severely obese PCa continued on page 10
IN THIS ISSUE 7
Mortality more likely in repeat renal transplant candidates
8
Contrast-enhanced ultrasound detects more high-grade PCa
12
Men’s Health Update: Walnuts improve sperm health
14
Adjuvanted influenza vaccine safe for kidney transplant patients
15
Radium-223 benefits confirmed for CRPC patients
20
Coronary artery calcification raises death risk in HD patients
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Cherries found to decrease gout attack risk Nutrition and metabolic acidosis in renal transplant recipients PAGE 22