Harry Brielmann, Ph. D. 14 Elm Street Guilford, CT 06437 (203) 457-0374 (home) (203) 738-9348 (cell, preferred) brielmannh@gmail.com linked in website youtube channel online chemistry textbook 2007-Present: Chemistry Teacher, Guilford High School, Guilford, Connecticut 2004: Chemistry Teacher, Glastonbury High School, Glastonbury, Connecticut 1998: Medicinal Chemist, Neurogen Corporation, Branford, CT Senior Scientist II. Responsible for development of small molecule drugs for neurological disorders based on bradykinin, neuropeptide Y, and vanilloid receptor 1. 1997: Instructor of Organic Chemistry, Wayne State University, Detroit, MI Full Time instructor of organic chemistry. Lecturer for 100 students for two semesters. 1996: Postdoctoral Fellow, Wayne State University, Detroit, MI Advisor: Professor John Montgomery. Research Topic: Organometallic research of low valent catalytic processes. 1995: Visiting Research Scholar, University of Michigan, Ann Arbor, MI Advisor: Professor Peter Kaufman. Research Topic: Natural products research of isoflavones. 1994: Postdoctoral Fellow, University of Hawai’i, Honolulu, HI Advisor: Professor Paul Scheuer. Research Topic: Performed marine natural products isolation and identification using SCUBA, 2-D NMR, and preparative HPLC techniques. 1989-1993: Ph. D. In Chemistry, Wesleyan University, Middletown, CT Research Advisor: Prof. Peter Jacobi. Research Topic: Synthesis of 5-alkylidene-2-cyclopentenones and ene pyrrolidinones. 1987-1988: M.S. in Chemistry, University of Massachusetts at Boston Research Advisor: Prof. Jean-Pierre Anselme. Research Topic: New synthetic approaches to pyrazoles and 1,3,4-oxadiazines. 1983-1986: Polymer Research Chemist, Ensign-Bickford Industries, Simsbury, CT Coinventor of photocurable polymeric optical fiber cladding material with attenuations of less than 1 db/km. Coinventor of photocurable glass bottle coating. 1981-1982: Cancer Research Chemist, The American Health Foundation, Valhalla, NY Responsible for synthesis of environmental carcinogens for in vivo analysis. 1977-1981: B. S. In Chemistry, University Of Connecticut Research Advisor: Prof. Sam Huang. Research Topic: New synthetic approach to Furaneol, a flavor principle of pineapples and strawberries. 1973-1977: High School Diploma, Conard High School, West Hartford, CT
Scientific Publications Scientific Journals The Guilford Journal of Chemistry (2006-2011, H. Brielmann, Editor). The premier, state of the art Journal for scientific research in Guilford, Connecticut. Books ChemistryAdventure: an interactive guide to chemistry. Brielmann, H., 2011 Book Chapters 1. Natural Products from Plants, 2nd Edition, CRC Press, Peter B. Kaufman, Editor. Chapter 1: H. Brielmann, W. Setzer, Phytochemicals: The Chemical Components of Plants (2005). 2. Handbook of Molecular and Cellular Methods in Biology and Medicine, 2 nd Edition CRC Press, Peter B. Kaufman, Editor. Chapter 24; H. Brielmann, Combinatorial Methods (2003). Magazines (online) Introduction to Chemistry Data Matter The Atom Electrons The Periodic Table Solutions Reactions The Mole Gases Energy Reaction Rates Equilibrium Acids and Bases U.S. Patents 1 7,662,830 Substituted biaryl piperazinyl-pyridine analogues (2010) 2 7,432,275 Carboxylic acid, phosphate or phosphonate substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators 3 7,329,664 Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues 4 7,304,059 Substituted quinazolin-4-ylamine analogues 5 7,074,799 6 7,034,034 7 6,566,367 8 6,358,949 9 5,455,087 10 5,112,658 11 4,707,076
Substituted quinazolin-4-ylamine analogues Substituted 2-cyclohexyl-4-phenyl-1H-imidazole derivatives Spiro[isobenzofuran-1,4'-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4'-piperidines Aryl and hetroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors Coating composition for glass containers Coating compositions for glass containers Coating compositions for optical fibers
Research Publications 1. Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists. Blum CA, Caldwell T, Zheng X, Bakthavatchalam R, Capitosti S, Brielmann H, De Lombaert S, Kershaw MT, Matson D, Krause JE, Cortright D, Crandall M, Martin WJ, Murphy BA, Boyce S, Jones AB, Mason G, Rycroft W, Perrett H, Conley R, Burnaby-Davies N, Chenard BL, Hodgetts KJ. J Med Chem. (2010) 53(8), 3330-48. 2. Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution. Blum CA, Zheng X, Brielmann H, Hodgetts KJ, Bakthavatchalam R, Chandrasekhar J, Krause JE, Cortright D, Matson D, Crandall M, Ngo CK, Fung L, Day M, Kershaw M, De Lombaert S, Chenard BL. Bioorg Med Chem Lett. (2008),18(16), 4573-7. 3. From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist. Zheng X, Hodgetts KJ, Brielmann H, Hutchison A, Burkamp F, Brian Jones A, Blurton P, Clarkson R, Chandrasekhar J, Bakthavatchalam R, De Lombaert S, Crandall M, Cortright D, Blum CA.Bioorg Med Chem Lett. 2006 Oct 1;16(19):5217-21 4. Nickel-catalyzed heterocycle construction with stereoselective exocyclic alkene introduction. Montgomery, J., Chevliakov, M.V., Brielmann, H. L. Tetrahedron (1997), 53, 16449-16462. 5. Cyclic Enamides from Acetylenic Amides. Jacobi, P. A., Brielmann, H. L., Hauck, S. I. Journal of Organic Chemistry (1996), 61(15), 5013-5023. 6. New synthetic approaches to 5-alkylidene-2-cyclopentenones and ene pyrrolidinones. Brielmann, Harry. Wesleyan Univ., Middletown, CT, USA. Avail. Univ. Microfilms Int., Order No. DA9532481 (1994). 7. Synthesis of cyclic enamides by intramolecular cyclization of acetylenic amides. Jacobi, Peter A.; Brielmann, Harry L.; Hauck, Sheila I. Tetrahedron Letters (1995), 36(8), 1193-6. 8. Enynones in Organic Synthesis. 7. Substituent Effects on the Tocopherol-Catalyzed Cyclization of Enynones to Methylenecyclopentenones. Convenient Syntheses of Members of the Methylenomycin Class of Antibiotics. Jacobi, Peter A.; Brielmann, Harry L.; Cann, Reginald O. Journal of Organic Chemistry (1995), 59(18), 5305-16. 9. Enynones in Organic Synthesis. 6. Synthesis of Spirocyclic Methylenecyclopentenones and Analogs of the Methylenomycin Class of Antibiotics. Mechanism of Phenol Catalysis. Jacobi, Peter A.; Armacost, Lisa M.; Brielmann, Harry L.; Cann, Reginald O.; Kravitz, Joseph I.; Martinelli, Michael JJournal of Organic Chemistry (1994), 59(18), 5292-304. 10. A study of chemical carcinogenesis. 57. Synthesis and mutagenicity of dihydrodiol metabolites of benzo[b]fluoranthene. Amin, Shantu; Hussain, Nalband; Brielmann, Harry; Hecht, Stephen S. Naylor Dana Inst. Dis. Prev., Am. Health Found., Valhalla, NY, USA. Journal of Organic Chemistry (1984), 49(6), 1091-5.