HIV Plus 2013 Treatment Guide

2013 HIV COMPLETE

TREATMENT

GUIDE

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HIV plus

J U LY/A U G U S T 2 0 1 3

Everyone needs to know about the meds we take, so HIV Plus offers our most comprehensive look ever at the medications approved by the Food and Drug Administration for the treatment of HIV and opportunistic infections, as well as a state-by-state map of drug assistance programs, complementary therapies, and drug trials. Remember, before you take anything you should talk with your doctor about what meds you’re on, any drug allergies, whether you smoke, drink, or take other supplements or recreational drugs, if you breast-feed, or are pregnant or want to be. This info was culled from the National Institutes of Health’s drug database, the FDA, and the individual pharmaceutical companies.

THE 2013 COMPLETE HIV TREATMENT GUIDE

JLIN?;M? CHBC<CNILM B?FJ JL?P?HN L?JFC=;NCIH I@ BCP MEDICATION 4R[R_VP ;NZR =Q[Ub

PREZISTA QN_b[NcV_ :Q^ccU^

REYATAZ NaNgN[NcV_ 2bYcd_\ =iUbc CaeYRR

APTIVUS aV]_N[NcV_ 2_UXbY^WUb 9^WU\XUY]

CRIXIVAN V[QV[NcV_ =UbS[

14

HIV plus

TRADITIONAL DOSAGE

DRUG INTERACTIONS, PRECAUTIONS, & RECOMMENDATIONS

Two 400-mg capsules or one 800-mg tablet with one 100-mg Norvir capsule, once daily, with food

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300 mg, in capsule form, taken with 100 mg of Norvir, once daily, with food. For adults unable to tolerate Norvir, 400 mg of Reyataz with food is recommended.

Take at the same time every day

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500 mg (two 250mg capsules or 5 milliliters of oral solution) with 200 mg (two 100-mg capsules/tablets or 2.5 milliliters of solution) of Norvir, twice daily. Capsules or solution may be taken with or without meals; tablets must be taken with meals

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800 mg, taken every eight hours, with water or another beverage, without food (one hour before or two hours after a meal) or with a light meal

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J U LY/A U G U S T 2 0 1 3

SIDE EFFECTS

JLIN?;M? CHBC<CNILM B?FJ JL?P?HN L?JFC=;NCIH I@ BCP MEDICATION MEDICATION 4R[R_VP ;NZR 4R[R_VP ;NZR =Q[Ub =Q[Ub

INVIRASE `N^bV[NcV_ ZR`fYNaR 8_ç]Q^^ <Q B_SXU

KALETRA Y\]V[NcV_ N[Q _Va\[NcV_ 1RR_dd <QR_bQd_bYUc

LEXIVA S\`NZ]_R[NcV_ FYYF 8UQ\dXSQbU

TRADITIONAL DOSAGE

DRUG INTERACTIONS, PRECAUTIONS, & RECOMMENDATIONS

1,000 mg (five 200-mg capsules or two 500mg tablets), in combination with 100 mg of Norvir, twice daily, at least two hours after a meal

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800 mg, typically four tablets, once daily, or 400 mg, typically two tablets, twice daily. Swallow tablets whole; do not chew, break, or crush.

An oral solution is available but should be taken with food

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For those used to protease inhibitors, 700 mg plus a 100-mg capsule of Norvir, twice daily. For those new to therapy, 1,400 mg of Lexiva twice daily, sometimes paired with Norvir, depending on the patient. Lexiva is available in tablets or oral solution; tablets can be taken with or without food, oral solution without food.

Reduced dosage recommended for patients with liver impairment

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SIDE SIDE EFFECTS EFFECTS

J U LY/A U G U S T 2 0 1 3 HIV plus

15

THE 2013 COMPLETE HIV TREATMENT GUIDE

JLIN?;M? CHBC<CNILM B?FJ JL?P?HN L?JFC=;NCIH I@ BCP MEDICATION 4R[R_VP ;NZR =Q[Ub

NORVIR

_Va\[NcV_ 1RR_dd <QR_bQd_bYUc

VIRACEPT

[RYº[NcV_

FYYF 8UQ\dXSQbU

TRADITIONAL DOSAGE

DRUG INTERACTIONS, PRECAUTIONS, & RECOMMENDATIONS

600 mg (six 100mg tablets), twice daily, with a meal.

Swallow tablets whole with water; do not chew, break, or crush.

Also available in capsules or oral solution.

Reduced dosage recommended for people taking other protease inhibitors

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1,250 mg (five 250-mg tablets or two 625-mg tablets), twice daily, or 750 milligrams (three 250-mg tablets) three times daily.

Each dose should be taken with a meal. An oral powder is also available

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SIDE EFFECTS

?HNLS ;H> @OMCIH CHBC<CNILM B?FJ <FI=E BCP @LIG ?HN?LCHA N =?FFM MEDICATION 4R[R_VP ;NZR =Q[Ub

TRADITIONAL DOSAGE

SELZENTRY

300 mg twice daily, or 150 mg twice daily if given with potent CYP3A inhibitors, or 600 mg twice daily if given with potent CYP3A inducers

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FYYF 8UQ\dXSQbU

20

HIV plus

J U LY/A U G U S T 2 0 1 3

WHAT IT DOES

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DRUG INTERACTIONS, PRECAUTIONS, & RECOMMENDATIONS

4_ ^_d dQ[U CQY^d :_X^ºc g_bd Qc Yd SQ^ \_gUb dXU Q]_e^d _V CU\jU^ dbi Y^ dXU R\__T C_]U _dXUb ]UTY SQdY_^c ]Qi Q\c_ QçUSd dXU Q]_e^d _V CU\jU^dbi Y^ dXU R\__T DU\\ i_eb T_Sd_b YV i_e XQfU Q XYcd_bi _V XU`QdYdYc 2 _b 3 XQfU XUQbd _b [YT^Ui `b_R\U]c _V YV i_e XQfU \_g R\__T `bUccebU _b dQ[U ]UTYSQdY_^ d_ \_gUb Yd

SIDE EFFECTS

=_cd cUbY_ec* XUQbd _b \YfUb TYc_bTUbc \_gUbUT R\__T `bUc cebU gXU^ cdQ^TY^W e` `_c cYR\U Y^SbUQcUT bYc[ _V SQ^SUb Q^T _dXUb Y^VUSdY_^c SXQ^W Uc Y^ dXU Y]]e^U cicdU] cUfUbU bQcX _b Q\\UbWYS bUQS dY_^ \UQTY^W d_ XU`d_d_hYSYdi ?dXUb* S_eWX VUfUb TYjjY^Ucc XUQTQSXU \_gUbUT R\__T `bUc cebU ^QecUQ R\QTTUb YbbYdQdY_^ e``Ub bUc`YbQd_bi Y^VUSdY_^

?HNLS ;H> @OMCIH CHBC<CNILM B?FJ <FI=E BCP @LIG ?HN?LCHA N =?FFM MEDICATION 4R[R_VP ;NZR =Q[Ub

FUZEON

R[SbcV_aVQR B_SXU <QR_bQd_bYUc RbQ^T ^Q]U DbY]UbYc WU^UbYS

TRADITIONAL DOSAGE

Injection of 90 mg in the upper arm, upper leg, or stomach twice daily

WHAT IT DOES

DXYc Yc Q^_dXUb ]USXQ^Yc] _V Y^XYRYdY^W fYbQ\ bU`\YSQdY_^ 1\gQic dQ[U^ gYdX _dXUb Q^dY 89F ]UTYSQdY_^c

DRUG INTERACTIONS, PRECAUTIONS, & RECOMMENDATIONS

C_]U `U_`\U ecU dXU 2Y_ZUSd_b " Q ^UUT\U VbUU TUfYSU d_ QT]Y^Yc dUb 6ejU_^ Red Y^ c_]U Yd SQecUc ^UbfU `QY^ dY^ W\Y^W RbeYcY^W Q^T S_\ \USdY_^ _V R\__T e^TUb dXU c[Y^

SIDE EFFECTS

=_cd cUbY_ec* Y^ZUSdY_^ cYdU Y^VUSdY_^c _b bUQS dY_^c ceSX Qc YdSXY^W cgU\\Y^W bUT^Ucc `QY^ _b dU^TUb^Ucc XQbTU^UT c[Y^ Re]`c Qd dXU cYdU _V Y^ZUSdY_^+ Q\\UbWYS bUQSdY_^c¶Q\c_ `QdYU^dc dQ[Y^W 6ejU_^ ]Qi TUfU\_` RQSdUbYQ\ `^Ue]_^YQ ]_bU _VdU^ dXQ^ _dXUbc Q\dX_eWX Yd Yc e^S\UQb YV dXU TbeW Yc dXU SQecU ?dXUb* `QY^ Q^T ^e]R^Ucc Y^ VUUd _b \UWc \_cc _V c\UU` TU`bUccY_^ TUSbUQcUT Q``UdYdU cY^ec `b_R\U]c U^\QbWUT \i]`X ^_TUc gUYWXd TUSbUQcU gUQ[^Ucc _b \_cc _V cdbU^WdX ]ecS\U `QY^ S_^cdY`QdY_^ Q^T `Q^SbUQc `b_R\U]c

CHN?AL;M? CHBC<CNILM B?FJ <FI=E ;H BCP'?H;<FCHA ?HTSG? ISENTRESS _NYaRT_NcV_

=UbS[

One 400-mg tablet, twice daily

2\_S[c Y^dUWbQcU Q^ U^ji]U 89F ^UUTc d_ bU`b_TeSU YdcU\V 1\gQic dQ[U^ gYdX _dXUb Q^dY 89F ]UTYSQdY_^c

DU\\ i_eb T_Sd_b YV i_e dQ[U dXU deRUbSe\_cYc ]UTYSQdY_^ bYVQ]`Y^ _b YV i_e XQfU \YfUb `b_R\U]c _b `XU^i\[Ud_^ebYQ 9V i_e ]Ycc Q T_cU c[Y` dXU ]YccUT T_cU Q^T W_ RQS[ d_ i_eb bUWe\Qb cSXUTe\U 4_ ^_d T_eR\U i_eb ^Uhd T_cU

=_cd cUbY_ec* cUfUbU c[Y^ bUQSdY_^c Q^T Q\\UbWYS bUQSdY_^c \YfUb `b_R\U]c SXQ^WUc Y^ i_eb Y]]e^U cicdU] ?dXUb* XUQTQSXU db_eR\U c\UU`Y^W ^QecUQ dYbUT^Ucc+ \Ucc S_]]_^ cYTU UçUSdc Y^S\eTU gUQ[^Ucc cd_]QSX `QY^ TYjjY^Ucc TU`bUccY_^ Q^T ceYSYTQ\ dX_eWXdc Q^T QSdY_^c

THE 2013 COMPLETE HIV TREATMENT GUIDE

HO=F?IMC>? L?P?LM? NL;HM=LCJN;M? CHBC<CNILM "HLNC# B?FJ JL?P?HN L?JFC=;NCIH I@ BCP MEDICATION 4R[R_VP ;NZR =Q[Ub

TRUVADA

RZa_VPVaNOV[R N[Q aR[\S\cV_ QV`\]_\eVY SbZN_NaR 7Y\UQT CSYU^SUc

COMBIVIR

YNZVcbQV[R N[Q gVQ\cbQV[R FYYF 8UQ\dXSQbU 2bQ^T ^Q]U DUfQ @XQb]QSUedYSQ\c 7U^UbYS

EMTRIVA

RZa_VPVaNOV[R

7Y\UQT CSYU^SUc

EPIVIR

YNZVcbQV[R \_ A0 FYYF 8UQ\dXSQbU

22

HIV plus

TRADITIONAL DOSAGE

DRUG INTERACTIONS, PRECAUTIONS, & RECOMMENDATIONS

One tablet, containing 200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate, once daily

DbefQTQ S_^dQY^c dg_ >BD9c gXYSX QSd _^ bUfUbcU dbQ^ cSbY`dQcU Q ceRcdQ^SU 89F ^UUTc V_b bU`\YSQdY_^ 4_ ^_d dQ[U DbefQTQ YV i_e dQ[U 1dbY`\Q 3_]RYfYb 5]dbYfQ 5`YfYb _b 5`YfYb 82F 5`jYS_] DbYjYfYb _b FYbUQT gXYSX XQfU dXU cQ]U _b cY]Y\Qb QSdYfU Y^WbUTYU^dc I_e ]Qi ^UUT d_ QTZecd T_cQWU YV Q\c_ dQ[Y^W FYTUh BUiQdQj _b ;Q\UdbQ 4_ ^_d dQ[U gYdX 8U`cUbQ 9V i_e XQfU XQT [YT^Ui `b_R\U]c _b dQ[U _dXUb TbeWc dXQd SQ^ SQecU [YT^Ui `b_R\U]c i_eb T_Sd_b cX_e\T T_ bUWe\Qb R\__T dUcdc d_ SXUS[ i_eb [YT^Uic 9^ " !" dXU 641 Q``b_fUT DbefQTQ V_b ecU Y^ 89F `bUfU^ dY_^ Q]_^W 89F ^UWQdYfU `U_`\U gX_ QbU Qd XYWX bYc[ _V QSaeYbY^W dXU fYbec DXU 641ºc e`TQdUT \QRU\Y^W _^ dXU TbeW ^_dUc dXQd `Ubc_^c ecY^W dXU TbeW `bUfU^dQdYfU\i ^UUT d_ RU S_^Âb]UT Qc 89F ^UWQdYfU UfUbi dXbUU ]_^dXc Q^T ecU dXU TbeW Qc `bUcSbYRUT Y^ S_]RY^QdY_^ gYdX cQVUb cUh `bQSdYSUc Q^T S_e^cU\Y^W

=_cd cUbY_ec* ReY\Te` _V \QSdYS QSYT Y^ dXU R\__T cUbY_ec \YfUb `b_R\U]c ÃQbU e`c _V XU`QdYdYc 2 fYbec Y^VUS dY_^ [YT^Ui `b_R\U]c dXY^^Y^W R_^Uc SXQ^WUc Y^ R_Ti VQd ci]`d_]c _V Y^ÃQ]]QdY_^ Vb_] `bUfY_ec Y^VUS dY_^c ?dXUb* TYQbbXUQ TYjjY^Ucc ^QecUQ f_]YdY^W XUQTQSXU VQdYWeU QR^_b]Q\ TbUQ]c c\UU`Y^W `b_R\U]c bQcX TU`bUccY_^ cX_bd^Ucc _V RbUQdX `QY^ VQddi \YfUb cd_]QSX `QY^ gUQ[ ^Ucc Y^TYWUcdY_^ Y^dUcdY^Q\ WQc XYWX f_\e]U _V ebY^U UhSUccYfU dXYbcd c[Y^ TYcS_\_bQdY_^ 9^ `QdYU^dc ecY^W Dbe fQTQ V_b `bUfU^dY_^ dXU ]_cd S_] ]_^ cYTU UçUSdc XQfU RUU^ XUQTQSXU QRT_]Y^Q\ `QY^ Q^T gUYWXd \_cc

One tablet, containing 150 mg of lamivudine and 300 mg zidovudine (both NRTIs), twice daily

4_ ^_d dQ[U gYdX _dXUb ]UTYSY^Uc S_^dQY^Y^W \Q]YfeTY^U jYT_feTY^U _b U]dbYSYdQRY^U ceSX Qc 5`YfYb 5`YfYb 82F BUdb_fYb 5`jYS_] DbYjYfYb 1dbY`\Q 5]dbYfQ Q^T DbefQTQ EcU SQedY_^ gYdX YV dQ[Y^W Y^dUbVUb_^ Q\VQ bYRQfYbY^ T_h_be RYSY^ _b WQ^SYS\_fYb DU\\ i_eb T_Sd_b YV i_eºfU `bUfY_ec\i XQT Q^i [YT^Ui _b \YfUb `b_R\U]c ceSX Qc XU`QdYdYc _b SYbbX_cYc `Q^SbUQdYdYc _b \_g bUT gXYdU R\__T SU\\ S_e^dc

=_cd cUbY_ec* \_g gXYdU Q^T bUT R\__T SU\\ S_e^dc cUbY_ec Q\\UbWYS bUQSdY_^c ReY\Te` _V \QSdYS QSYT Y^ dXU R\__T \YfUb d_hYSYdi _b g_bcU^Y^W _V \YfUb TYcUQcU `Q^SbUQdYdYc ]ecS\U TYc_bTUbc Q^T Y^ÃQ]]QdY_^ SXQ^W Uc Y^ R_Ti VQd SXQ^WUc Y^ dXU Y]]e^U cicdU] ?dXUb* XUQTQSXU ^QecUQ VQdYWeU TYQbbXUQ S_eWX cdeçi ^_cU WU^UbQ\ VUU\Y^W _V TYcS_]V_bd

One 200-mg capsule or 240 mg of oral solution, once daily

4_ ^_d ecU gYdX _dXUb TbeWc S_^dQY^Y^W U]dbYSYdQRY^U ceSX Qc 1dbY`\Q 3_]`\UbQ DbefQTQ _b CdbYRY\T

=_cd cUbY_ec* ReY\Te` _V \QSdYS QSYT Y^ dXU R\__T \YfUb `b_R\U]c Y^S\eTY^W ÃQbU e` _V XU`QdYdYc 2 QVdUb TYcS_^ dY^eQdY_^ ?dXUb* XUQTQSXU TYQbbXUQ ^QecUQ VQdYWeU TYjjY^Ucc TU`bUc cY_^ Y^c_]^YQ QR^_b]Q\ TbUQ]c bQcX QRT_]Y^Q\ `QY^ QcdXU^YQ Y^SbUQcUT S_eWX bXY^YdYc

300 mg daily, in one or two doses, in tablets or oral solution

4_ ^_d dQ[U gYdX 5]dbYfQ 3_]RYfYb 5`jYS_] DbYjYfYb 1dbY`\Q DbefQTQ CdbYRY\T _b 3_]`\UbQ 5`YfYb Yc ^_d bUS_] ]U^TUT V_b ecU Y^ S_]RY^QdY_^ gYdX jQ\SYdQRY^U 9V i_e XQfU XU`QdYdYc 3 dXUbU Yc Q SXQ^SU _V cUfUbU \YfUb TUS_]`_cYdY_^ YV i_e QbU dQ[Y^W S_]RY^QdY_^ Q^dYbUdb_fYbQ\ dXUbQ`i Q^T Y^dUbVUb_^ Q\VQ TbeWc V_b XU` 3

=_cd cUbY_ec* ReY\Te` _V \QSdYS QSYT Y^ dXU R\__T cUfUbU \YfUb `b_R\U]c SXQ^WUc Y^ dXU Y]]e^U cicdU] SXQ^WUc Y^ R_Ti VQd ?dXUb* XUQTQSXU ^QecUQ ]Q\QYcU Q^T VQdYWeU ^QcQ\ `b_R\U]c TYQbbXUQ Q^T S_eWX

J U LY/A U G U S T 2 0 1 3

SIDE EFFECTS

HO=F?IMC>? L?P?LM? NL;HM=LCJN;M? CHBC<CNILM "HLNC# B?FJ JL?P?HN L?JFC=;NCIH I@ BCP MEDICATION 4R[R_VP ;NZR =Q[Ub

EPZICOM

NONPNcV_ `bYSNaR N[Q YNZVcbQV[R FYYF 8UQ\dXSQbU

RETROVIR

gVQ\cbQV[R \_ .GA

FYYF 8UQ\dXSQbU+ WU^UbYS fUbcY_^c Q\c_ QfQY\QR\U

TRIZIVIR

NONPNcV_ `bYSNaR YNZVcbQV[R N[Q gVQ\cbQV[R

TRADITIONAL DOSAGE

DRUG INTERACTIONS, PRECAUTIONS, & RECOMMENDATIONS

One tablet, containing 600 mg of abacavir sulfate and 300 mg of lamivudine (both NRTIs), once daily

4_ ^_d dQ[U YV i_e XQfU [YT^Ui `b_R\U]c _b QbU `b_^U d_ XUQbd TYcUQcU EcU gYdX SQedY_^ YV i_e Q\bUQTi dQ[U 1dbY`\Q 3_]RYfYb 5]dbYfQ 5`YfYb DbYjYfYb DbefQTQ JYQWU^ ]UdXQT_^U _b ]UTYSY^Uc ecUT d_ dbUQd XU`QdY dYc 9V i_e XQfU XU`QdYdYc 2 T_ ^_d be^ _ed _V 5`jYS_] _b cd_` dQ[Y^W Yd gYdX_ed dQ\[Y^W d_ i_eb XUQ\dX SQbU `b_ fYTUb I_eb `b_fYTUb cX_e\T ]_^Yd_b i_eb XUQ\dX Q^T T_ bUWe\Qb R\__T dUcdc d_ SXUS[ i_eb \YfUb YV i_e cd_` dQ[Y^W 5`jYS_] 4_ ^_d dQ[U YV i_e XQfU ]_TUbQdU d_ cUfUbU \YfUb `b_R\U]c

=_cd cUbY_ec* cUfUbU Q\\UbWYS bUQS dY_^c ReY\Te` _V QSYT Y^ dXU R\__T \YfUb `b_R\U]c ?dXUb* Y^c_]^YQ TU`bUccY_^ XUQTQSXU dYbUT^Ucc TYjjY^Ucc ^QecUQ TYQbbXUQ bQcX Q^T VUfUb

600 mg a day, taken in divided doses, in tablets, capsule, or syrup. Can also be given as an intravenous infusion, one mg per kilogram of body weight, over one hour, five or six times daily

4_ ^_d dQ[U gYdX _dXUb ]UTYSY^Uc dXQd S_^dQY^ dXU cQ]U QSdYfU Y^WbUTYU^dc Y^S\eTY^W 3_]RYfYb Q^T DbYjYfYb >_d bUS_]]U^TUT V_b ecU gYdX dXU Q^dYXU`QdYdYc TbeWc 3_`UWec BURUd_\ BYRQDQR _b BYRQc`XUbU EcU gYdX SQedY_^ YV dQ[Y^W WQ^SYS\_fYb _b Y^dUbVUb_^ Q\VQ 4_ ^_d ecU BUdb_fYb gYdX cdQfeTY^U _b T_h_beRYSY^ BUdb_fYb SQ^ Q\c_ RU ecUT d_ `bUfU^d dbQ^c]YccY_^ _V 89F Vb_] Q ]_dXUb d_ XUb e^R_b^ SXY\T

=_cd cUbY_ec* ^Uedb_`U^YQ Q^T Q^U]YQ \_g gXYdU Q^T bUT R\__T SU\\ S_e^dc ]i_`QdXi Q^T ]i_cYdYc ]ecS\U TYc_bTUbc Q^T Y^ÃQ]]Q dY_^ ReY\Te` _V \QSdYS QSYT Y^ dXU R\__T cUfUbU \YfUb `b_R\U]c SXQ^W Uc Y^ dXU Y]]e^U cicdU] SXQ^WUc Y^ R_Ti VQd ?dXUb* XUQTQSXU ]Q\QYcU ^QecUQ Q^_bUhYQ Q^T f_]YdY^W

One tablet (300 mg of abacavir sulfate, 150 mg of lamivudine, and 300 mg of zidovudine, all NRTIs), twice daily

4_ ^_d dQ[U YV i_e XQfU SUbdQY^ \YfUb `b_R\U]c _b gUYWX \Ucc dXQ^ ) `_e^Tc DQ[U gYdX SQedY_^ YV i_e XQfU Q `QbdYSe\Qb WU^U fQbYQdY_^ SQ\\UT 8<1 2 %' ! XU`QdYdYc 2 [YT^Ui _b XUQbd `b_R\U]c \_g R\__T SU\\ S_e^dc XYWX R\__T `bUccebU XYWX SX_\UcdUb_\ _b TYQRUdUc EcU gYdX SQedY_^ YV i_e dQ[U 2QSdbY] CU`dbQ 3id_fU^U 48@7 Y^dUbVUb_^ Q\VQ 1TbYQ]iSY^ 3_`UWic BURUd_\ FYbQ j_\U R_^U ]Qbb_g ce``bUccYfU ]UTYSY^Uc _b Sid_d_hYS ]UTYSY^Uc 1dbY`\Q 3_]RYfYb 3_]`\UbQ 5]dbYfQ 5`Y fYb _b 5`YfYb 82F 5`jYS_] BUdb_fYb DbefQTQ JUbYd _b JYQWU^

=_cd cUbY_ec* cUfUbU _b VQdQ\ Q\\Ub WYS bUQSdY_^c XUQbd QddQS[ ReY\Te` _V \QSdYS QSYT Y^ dXU R\__T \YfUb TYc_b TUbc R\__T `b_R\U]c ]ecS\U gUQ[ ^Ucc SXQ^WUc Y^ R_Ti VQd SXQ^WUc Y^ Y]]e^U cicdU] ?dXUb* ^QecUQ f_]YdY^W XUQTQSXU gUQ[^Ucc _b dYbUT^Ucc TYQbbXUQ VUfUb Q^T _b SXY\\c TU`bUccY_^ ]ecS\U Q^T Z_Y^d `QY^ c[Y^ bQcXUc S_\T ci]`d_]c ^Ubf_ec^Ucc Q^T UQb ^_cU Q^T dXb_Qd Y^VUSdY_^c

Depends on weight.

For individuals weighing 132 pounds or more, the recommended dose is 400 mg in enteric-coated capsules, once daily.

For adults weighing less than 132 pounds, the recommended dose is 250 mg, once daily. Take the drug on an empty stomach, and swallow the capsules whole; do not chew, break, crush, or dissolve. A powder form to be mixed with water is available for children

4_ ^_d dQ[U YV i_e dQ[U <_`ebY^ _b Ji\_`bY] gXYSX QbU ecUT d_ dbUQd W_ed Q^T [YT^Ui cd_^Uc _b dXU Q^dYXU`Q dYdYc TbeWc 3_`UWec BURUd_\ BYRQ DQR _b BYRQc`XUbU EcU gYdX SQedY_^ YV dQ[Y^W ]UdXQT_^U _b WQ^SYS\_fYb _b Q^i TbeWc dXQd ]Qi SQecU d_hYSYdi d_ dXU `Q^SbUQc _b ^Ubf_ec cicdU] 9V i_e QbU Q\c_ dQ[Y^W FYbUQT dXU T_cU _V FYTUh 53 cX_e\T RU bUTeSUT Q^T Yd cX_e\T RU dQ[U^ _^ Q^ U]`di cd_]QSX _b gYdX Q \YWXd ]UQ\

=_cd cUbY_ec* `Q^SbUQdYdYc ReY\Te` _V \QSdYS QSYT Y^ dXU R\__T \YfUb TYc _bTUbc fYcY_^ `b_R\U]c SXQ^WUc Y^ Y]]e^U cicdU] SXQ^WUc Y^ R_Ti VQd `UbY`XUbQ\ ^Ueb_`QdXi ?dXUb* TYQbbXUQ ^QecUQ f_]YdY^W XUQT QSXU cd_]QSX `QY^ c[Y^ bQcX

FYYF 8UQ\dXSQbU

VIDEX EC QVQN[\`V[R 2bYcd_\ =iUbc CaeYRR

SIDE EFFECTS

J U LY/A U G U S T 2 0 1 3 HIV plus

23

THE 2013 COMPLETE HIV TREATMENT GUIDE

HO=F?IMC>? L?P?LM? NL;HM=LCJN;M? CHBC<CNILM "HLNC# B?FJ JL?P?HN L?JFC=;NCIH I@ BCP MEDICATION 4R[R_VP ;NZR =Q[Ub

VIREAD

aR[\S\cV_ QV`\]_\eVY SbZN_NaR 7Y\UQT CSYU^SUc

ZERIT

`aNcbQV[R \_ Q!A

2bYcd_\ =iUbc CaeYRR

ZIAGEN

NONPNcV_

7\Qh_C]YdX;\Y^U

24

HIV plus

TRADITIONAL DOSAGE

DRUG INTERACTIONS, PRECAUTIONS, & RECOMMENDATIONS

One 300mg tablet, once daily.

Adults who are unable to swallow tablets whole may take 7 scoops of Viread oral powder.

Patients with kidney problems may be prescribed a lower dose

4_ ^_d dQ[U FYbUQT YV i_e QbU dQ[Y^W _dXUb ]UTYSY^Uc dXQd S_^dQY^ dU^_V_fYb 1dbY`\Q 3_]`\UbQ DbefQTQ _b CdbYRY\T _b QTUV_fYb 8U`cUbQ 4_cQWUc ]Qi ^UUT d_ RU SXQ^WUT YV i_e QbU dQ[Y^W FYTUh 53 BUiQdQj _b ;Q\UdbQ

For patients weighing 132 pounds or more, 40 mg, in capsules or oral solution, twice daily; for patients weighing less than 132 pounds, 30 mg twice daily

4_ ^_d dQ[U gYdX BUdb_fYb jYT_feTY^U _b Q^i jYT_feTY^U S_^dQY^Y^W `b_TeSdc ceSX Qc 3_]RYfYb _b DbYjYfYb 4_ ^_d dQ[U gYdX XiTb_hiebUQ gXYSX Yc ]Qb[UdUT e^TUb RbQ^T ^Q]Uc 4b_hYQ Q^T 8iTbUQ EcU gYdX SQedY_^ gYdX FYTUh 53 1TbYQ]iSY^ BeRUh 3_`UWec BURUd_\ BYRQc`XUbU FYbQj_\U B_VUb_^ 1 Q^T 9^db_^ 1 EcU gYdX SQedY_^ YV i_e XQfU \YfUb `Q^SbUQc _b [YT^Ui `b_R\U]c `UbY`XUbQ\ ^Ue b_`QdXi _b WQ\\cd_^Uc 6_b `QdYU^dc gYdX bU^Q\ Y]`QYb]U^d _b e^TUbW_Y^W XU]_TYQ\icYc T_cY^W QTZecd]U^dc ]Qi RU ^UUTUT 4_ ^_d TbY^[ Q\S_X_\ gXY\U _^ dXU TbeW

=_cd cUbY_ec* ReY\Te` _V Q^ QSYT Y^ dXU R\__T cUbY_ec \YfUb `b_R\U]c `Q^SbUQdYdYc SXQ^WUc Y^ R_Ti VQd SXQ^WUc Y^ Y]]e^U cicdU] `UbY`XUbQ\ ^Ueb_`QdXi ?dXUb* XUQTQSXU TYQbbXUQ bQcX ^QecUQ f_]YdY^W

600 mg in tablets daily, administered as either 300 mg twice daily or 600 mg once daily. Also available as an oral solution.

Patients with mild liver impairment should take 200 mg twice daily

4_ ^_d dQ[U YV i_e XQfU ]_TUbQdU d_ cUfUbU \YfUb Y]`QYb ]U^d 4_ ^_d RbUQcd VUUT gXY\U dQ[Y^W dXU TbeW 9V i_e XQfU Q cUfUbU Q\\UbWYS bUQSdY_^ T_ ^_d bUce]U dQ[Y^W JYQWU^ _b Q^i _dXUb QRQSQfYb S_^dQY^Y^W TbeW 5`jYS_] DbYjYfYb BYc[ _V Q\\UbWYS bUQSdY_^ Yc XYWXUb YV i_e XQfU Q WU^U fQbYQdY_^ SQ\\UT 8<1 2 %' !

=_cd cUbY_ec* cUfUbU Q\\UbWYS bUQSdY_^ ReY\Te` _V \QSdYS QSYT Y^ dXU R\__T gYdX \YfUb U^\QbWU]U^d SXQ^WUc Y^ R_Ti VQd SXQ^WUc Y^ Y]]e^U cicdU] Y^SbUQcUT bYc[ _V XUQbd QddQS[ Uc`USYQ\\i YV i_e XQfU _dXUb bYc[ VQSd_bc ceSX Qc c]_[Y^W XYcd_bi _V XUQbd db_eR\U TYQRUdUc XYWX R\__T `bUccebU _b XYWX SX_\UcdUb_\ ?dXUb* ^QecUQ f_]YdY^W dYbUT^Ucc XUQTQSXU TYQbbXUQ db_eR\U c\UU`Y^W VUfUb Q^T SXY\\c Q^T \_cc _V Q``UdYdU

Â&#x17E; J U LY/A U G U S T 2 0 1 3

FYbUQT Yc Q\c_ ecUT d_ dbUQd XU`QdYdYc 2

SIDE EFFECTS

=_cd cUbY_ec* ReY\Te` _V \QSdYS QSYT Y^ dXU R\__T cUfUbU \YfUb `b_R \U]c SXQ^WUc Y^ R_Ti VQd SXQ^WUc Y^ dXU Y]]e^U cicdU] R_^U `QY^ c_VdU^Y^W _b dXY^^Y^W ?dXUb* ^QecUQ bQcX TYQbbXUQ XUQTQSXU `QY^ TU`bUccY_^ gUQ[^Ucc

HIHHO=F?IMC>? L?P?LM? NL;HM=LCJN;M? CHBC<CNILM "HHLNC# B?FJ JL?P?HN L?JFC=;NCIH I@ BCP MEDICATION 4R[R_VP ;NZR =Q[Ub

EDURANT

_VY]VcV_V[R :Q^ccU^

INTELENCE Ra_NcV_V[R

:Q^ccU^

RESCRIPTOR

QRYNcV_QV[R

FYYF 8UQ\dXSQbU

SUSTIVA

RSNcV_R[g

2bYcd_\ =iUbc CaeYRR

VIRAMUNE [RcV_N]V[R

2_UXbY^WUb 9^WU\XUY]

TRADITIONAL DOSAGE

DRUG INTERACTIONS, PRECAUTIONS, & RECOMMENDATIONS

One 25-mg tablet, once daily, with a meal

>>BD9c QddQS[ dXU cQ]U U^ji]U >BD9c T_ Y^ Q TYçUbU^d gQi 4_ ^_d dQ[U 5TebQ^d gYdX Q^dYcUYjebU TbeWc \Y[U DUWbUd_\ DbY\U`dQ\ Q^T 4Y\Q^dY^+ Q^dYRQSdUbYQ\c =iS_RedY^ BYVQTY^ BY]QSdQ^U _b @bYVdY^+ `b_d_^ `e]` Y^XYRYd_bc ceSX Qc >UhYe] FY]_f_ @bUfQSYT @bY\_cUS @b_d_^Yh Q^T 1SY`XUh+ ]_bU dXQ^ _^U T_cU _V TUhQ]UdXQ c_^U+ _b CQY^d :_X^ºc g_bd EcU gYdX SQedY_^ gYdX Q^dYVe^WQ\c dQ[U^ _bQ\\i Q^dYRY_dYSc \Y[U 2YQhY^ Q^T UbidXb_]iSY^ Q^T ]UdXQT_^U DQ[U Q^dQSYTc _b 8" R\_S[Ubc Qd \UQcd !" X_ebc RUV_bU _b V_eb X_ebc QVdUb 5TebQ^d

=_cd cUbY_ec* TU`bUccY_^ _b ]__T SXQ^WUc Y^S\eTY^W ceY SYTQ\ dX_eWXdc+ SXQ^WUc Y^ R_Ti VQd+ SXQ^WUc Y^ Y]]e^U cicdU] ?dXUb* Y^c_]^YQ XUQTQSXU bQcX

200 mg (one 200-mg tablet or two 100-mg tablets), twice daily

4_ ^_d dQ[U gYdX dXU Q^dY 89F TbeWc 1SdYfec <UhYfQ BUiQdQj Ve\\ T_cU >_bfYb FYbQ]e^U CecdYfQ _b BUcSbY`d_b+ U`Y\U`ci Q^T cUYjebU ]UTYSY^Uc DUWbUd_\ 3QbRQdb_\ <e]Y^Q\ 4Y\Q^dY^ _b @XU^idU[+ XUbRQ\ `b_TeSdc S_^dQY^Y^W CQY^d :_X^ºc g_bd+ _b dXU Q^dYRQSdUbYQ\ TbeWc =iS_RedY^ BYVQTY^ BYVQdUb BYVQ]QdU _b @bYVdY^ 1\gQic dQ[U QVdUb Q ]UQ\ Q^T cgQ\\_g dXU `Y\\ gYdX Q Ve\\ W\Qcc _V gQdUb+ T_ ^_d SXUg

=_cd cUbY_ec* cUfUbU c[Y^ bQcX _b Q\\UbWYS bUQSdY_^ ?dXUb* SXQ^WUc Y^ R_Ti cXQ`U _b R_Ti VQd SXQ^WUc Y^ Y]]e^U cicdU] dY^W\Y^W _b `QY^ Y^ dXU XQ^Tc _b VUUd ^e]R^Ucc

400 mg (two or four tablets) three times daily

GXU^ dQ[Y^W BUcSbY`d_b T_ ^_d dQ[U FUbcUT 8Q\SY_^ HQ^Qh 4 8 5 $% 9^ZUSdY_^ 5bW_]Qb =YWbQ^Q\ GYWbQY^U 3QVUbW_d ?bQ` @b_`e\ cYT 8Yc]Q^Q\ CU\TQ^U bYVQ]`Y^ `XU^_RQbRYdQ\ 4Y\Q^dY^ DUWbUdb_\ CQY^d :_X^ºc g_bd =UfQS_b _b J_S_b DQ\[ d_ i_eb T_Sd_b RUV_bU dQ[ Y^W FYQWbQ <Y`Yd_b 2QiS_\ _b <UcS_\ 9V dQ[Y^W FYTUh _b Q^dQSYTc dQ[U Q^ X_eb RUV_bU _b Q^ X_eb QVdUb dQ[Y^W BUcSbY`d_b 4_cUc _V `b_dUQcU Y^XYRYd_bc 1WU^UbQcU 3bYhYfQ^ 9^fYbQcU 6_bd_fQcU ;Q\UdbQ >_bfYb Q^T FYbQSU`d ]Qi ^UUT d_ RU QTZecdUT DQ\[ gYdX i_eb T_Sd_b YV i_e XQfU \YfUb _b [YT^Ui TYcUQcU

=_cd cUbY_ec* cUfUbU c[Y^ bQcX QSS_]`Q^YUT Ri R\YcdUbc VUfUb Z_Y^d _b ]ecS\U `QY^ bUT^Ucc _b cgU\\Y^W _V dXU UiUc _b c_bUc Y^ dXU ]_edX ?dXUb* XUQTQSXU ^QecUQ TYQbbXUQ Q^T dYbUT^Ucc

600 mg (three capsules at once or one tablet), taken daily

4_ ^_d dQ[U 1dbY`\Q FQcS_b @b_`e\cYT FUbcUT ?bQ` 8Q\SY_^ _b UbW_d ]UTYSQdY_^c ceSX Qc GYWbQY^U Q^T 3QVUbW_d DXU V_\\_gY^W ]UTYSY^Uc ]Qi ^UUT d_ RU bU`\QSUT gYdX Q^_dXUb gXU^ i_e QbU dQ[Y^W CecdYfQ* 6_bd_fQcU 9^fYbQcU 2YQhY^ 3QbRQdb_\ DUWbUd_\ >_hQÂ\ C`_bQ^_h Q^T BUiQdQj YV dXYc Yc ^_d dXU Âbcd dY]U i_e XQfU RUU^ dbUQdUT V_b 89F DXU V_\\_gY^W TbeWc ]Qi bUaeYbU Q SXQ^WU Y^ dXU T_cU _V UYdXUb Cec dYfQ _b dXU _dXUb ]UTYSY^U* 3QbTYjU] DYQjQS 3_fUbQ 8C 9c_`dY^ CB <Y`Yd_b @bQfQSX_\ J_S_b 3bYhYfQ^ ;Q\UdbQ ]UdXQT_^U =iS_RedY^ BUiQdQj BYVQTY^ BYVQ]QdU BYVQdUb CU\jU^dbi FVU^T 7U^WbQV >U_bQ\ CQ^TY]]e^U @b_WbQV BQ`Q]e^U GU\\RedbY^ J_\_Vd Q^T JifQ^ 9V i_e QbU dQ[Y^W CecdYfQ Q^T BUiQdQj i_e cX_e\T Q\c_ RU dQ[Y^W >_bfYb DU\\ i_eb T_Sd_b YV i_e XQfU XQT XU`QdYdYc _b _dXUb \YfUb `b_R\U]c ]U^ dQ\ Y\\^Ucc _b cUYjebUc DQ[U CecdYfQ _^ Q^ U]`di cd_]QSX `bUVUbQR\i Qd RUTdY]U gYdX gQdUb

=_cd cUbY_ec* cUfUbU \YfUb `b_R\U]c bQcXUc Q^T c[Y^ bUQSdY_^c ?dXUb* SXQ^WUc Y^ dXU Y]]e^U cicdU] SXQ^WUc Y^ R_Ti VQd TYjjY^Ucc ^QecUQ XUQTQSXU Y^c_]^YQ dYbUT^Ucc

One 200-mg tablet daily for first 14 days, then one 200mg twice daily; also available in oral suspension

4_ ^_d dQ[U CQY^d :_X^ºc g_bd CecdYfQ 1dbY`\Q ;Q\UdbQ <UhYfQ BUiQdQj >Yj_bQ\ C`_bQ^_h BYVQTY^ BYVQ]QdU BYVQdUb _b RYbdX S_^ db_\ `Y\\c DU\\ T_Sd_b YV dQ[Y^W 2YQhY^ 4YÃeSQ^ 3bYhYfQ^ ]UdXQT_^U FYbQSU`d =iS_RedY^ 3_e]QTY^ :Q^d_fU^ _b 9^fYbQcU 4YcS_^dY^eU Y]]UTYQdU\i YV i_e TUfU\_` cYW^c _V XU`QdYdYc cUfUbU c[Y^ bUQSdY_^c _b bQcX gYdX cicdU]YS ci]`d_]c

=_cd cUbY_ec* cUfUbU `ciSXY QdbYS `b_R\U]c Y^S\eTY^W ceY SYTQ\ dX_eWXdc+ \YfUb TYc_bTUbc+ cUfUbU bQcX ?dXUb* TYjjY^Ucc ^QecUQ f_]YdY^W TYQbbXUQ bQcX c\UU` TYcdebRQ^SUc Tb_gcY^Ucc db_eR\U S_^SU^ dbQdY^W _b e^eceQ\ TbUQ]c

SIDE EFFECTS

J U LY/A U G U S T 2 0 1 3 HIV plus

25

=IG<CH;NCIH >LOAM B?FJ JL?P?HN L?JFC=;NCIH I@ BCP MEDICATION 4R[R_VP ;NZR =Q[Ub

STRIBILD RYcVaRT_NcV_ P\OVPV`aNa RZa_VPVaNOV[R aR[\S\cV_ QV`\]_\eVY SbZN_NaR 7Y\UQT CSYU^SUc

ATRIPLA RSNcV_R[g RZa_VPVaNOV[R N[Q aR[\S\cV_ QV`\]_\eVY SbZN_NaR 2bYcd_\ =iUbc CaeYRR 7Y\UQT CSYU^SUc

COMPLERA RZa_VPVaNOV[R _VY]VcV_V[R N[Q aR[\S\cV_ QV`\]_\eVY SbZN_NaR 7Y\UQT CSYU^SUc

TRADITIONAL DOSAGE

DRUG INTERACTIONS, PRECAUTIONS, & RECOMMENDATIONS

One tablet, once daily, with a meal (150 mg of elvitegravir, 150 mg of cobicistat, 200 mg of emtricitabine, and 300 mg of tenofovir disoproxil fumarate)

CdbYRY\T Yc ^_d Q``b_fUT V_b dbUQd]U^d _V `QdYU^dc gX_ XQfU XU`QdYdYc 2 Qc CdbYRY\T SQ^ UhQSUbRQdU dXU TYcUQcU Q^T SQecU ÃQbU e`c CdbYRY\T cX_e\T ^_d RU ecUT V_b `QdYU^dc gYdX Q^ UcdY]QdUT SbUQdY^Y^U S\UQbQ^SU RU\_g ' ]< `Ub ]Y^edU 4_ ^_d ecU gYdX _dXUb Q^dY 89F TbeWc S_^dQY^Y^W U]dbYSYdQRY^U _b dU^_V_fYb TYc_`b_hY\ Ve]QbQdU Y^S\eTY^W 1dbY`\Q 3_]`\UbQ 5]dbYfQ DbefQTQ _b FYbUQT+ T_ ^_d ecU gYdX TbeWc S_^dQY^Y^W \Q]YfeTY^U _b gYdX TbeWc _b bUWY]U^c S_^dQY^Y^W bYd_^QfYb ceSX Qc 3_]RYfYb 5`YfYb 5`YfYb 82F 5`jYS_] _b DbYjYfYb 4_ ^_d QT]Y^YcdUb Y^ S_]RY^QdY_^ gYdX 8U`cUbQ 4_ ^_d ecU gYdX cY\TU^QÂ\ gXU^ RbQ^TUT Qc BUfQdY_ dX_eWX cY\TU^QÂ\ gXU^ T_cUT Qc FYQWbQ ]Qi RU cQVU c_ S_^ce\d i_eb T_Sd_b 4_ ^_d ecU gYdX Q\Vej_cY^ bYVQ]`Y^ SYcQ`bYTU `Y]_jYTU _b dXU XUbRQ\ bU]UTi CQY^d :_X^ºc g_bd 4_ ^_d dQ[U CdbYRY\T gYdX UbW_d TUbYfQdYfUc ceSX Qc TYXiTb_UbW_dQ]Y^U UbW_dQ]Y^U _b ]UdXi\UbW_^_fY^U 8=7 3_1 BUTeSdQcU Y^XYRYd_bc ceSX Qc \_fQcdQdY^ Q^T cY]fQcdQdY^ _b gYdX cUTQdYfU Xi`^_dYSc

=_cd cUbY_ec* ReY\Te` _V \QSdYS QSYT Y^ dXU R\__T+ cUfUbU \YfUb _b [YT^Ui `b_R\U]c gXYSX S_e\T \UQT d_ `_dU^dYQ\\i VQdQ\ bU^Q\ VQY\ebU+ dXY^^Y^W R_^Uc Q^T SXQ^WUc Y^ dXU Y]]e^U cicdU] ?dXUb* ^QecUQ Q^T TYQbbXUQ

One tablet, once daily, on an empty stomach, preferably at bedtime (containing 600 mg of efavirenz, 200 mg of emtricitabine, and 300 mg of tenofovir disoproxil fumarate). If you are also taking Rifadin, add 200 mg of efavirenz

5VQfYbU^j Yc Q ^_^^eS\U_cYTU bUfUbcU dbQ^cSbY`dQcU Y^XYRY d_b >>BD9 dXU _dXUb S_]`_^U^dc QbU ^eS\U_cYTU bUfUbcU dbQ^cSbY`dQcU Y^XYRYd_bc >BD9c + dXU TYçUbU^d di`Uc _V TbeWc QddQS[ 89F Qd TYçUbU^d cdQWUc Y^ Ydc bU`\YSQdY_^ `b_SUcc 4_ ^_d dQ[U 1dbY`\Q gYdX Q^dY 89F TbeWc 3_]RYfYb 3_]`\UbQ 5]dbYfQ 5`YfYb _b 5`YfYb 82F 5`jYS_] DbYjYfYb DbefQTQ FYbUQT _b CdbYRY\T gXYSX XQfU dXU cQ]U _b cY]Y\Qb QSdYfU Y^WbUTYU^dc DQ[U gYdX CecdYfQ _^\i YV i_eb T_Sd_b bUS_] ]U^Tc 9V i_e QbU dQ[Y^W ;Q\UdbQ T_cQWU _V dXQd TbeW ]Qi ^UUT d_ RU QTZecdUT 4_ ^_d dQ[U gYdX FYSdbU\Yc FQcS_b @b_`e\cYT FUbcUT ?bQ` 8Q\SY_^ UbW_d ]UTYSQdY_^c ceSX Qc GYWbQY^U Q^T 3QVUbW_d FVU^T 8U`cUbQ _b dXU XUbRQ\ bU]UTi CQY^d :_X^ºc g_bd EcU gYdX SQedY_^ gYdX 6_bd_fQcU 9^fYbQcU FYTUh BUiQdQj 3bYhYfQ^ CU\jU^dbi 2YQhY^ >_hQÂ\ C`_bQ^_h SQ\SY e] SXQ^^U\ R\_S[Ubc ceSX Qc TY\dYQjU] Q^T fUbQ`Q]Y\ gXYSX XQfU fQbY_ec RbQ^T ^Q]Uc Y]]e^_ce``bUccQ^d TbeWc ceSX Qc SiS\_c`_bY^U dQSb_\Y]ec Q^T cYb_\Y]ec c_\T e^TUb fQbY_ec RbQ^T ^Q]Uc ]UdXQT_^U =iS_RedY^ BYVQTY^ BY]QSdQ^U <Y`Yd_b @bQfQSX_\ J_S_b J_\_Vd _b cUYjebU ]UTc ceSX Qc `XU^id_Y^ SQbRQ]QjU`Y^U Q^T `XU^_RQbRYdQ\ 9V i_e XQfU XU`QdYdYc 2 Q^T cd_` dQ[Y^W 1dbY`\Q i_e ]Qi Uh`UbYU^SU Q ÃQbU e` _V dXU TYcUQcU 4_ ^_d dQ[U YV i_e XQfU cUfUbU [YT^Ui Y]`QYb]U^d

=_cd cUbY_ec* ReY\Te` _V \QSdYS QSYT Y^ dXU R\__T cUfUbU \YfUb _b [YT^Ui `b_R\U]c cUbY_ec `ciSXY QdbYS `b_R\U]c dXY^^Y^W R_^Uc Q fYdQ]Y^ 4 ce``\U]U^d ]Qi RU Y^TYSQdUT V_b dXU \QddUb ?dXUb* TYjjY^Ucc XUQTQSXU Y^c_]^YQ Tb_gcY^Ucc db_eR\U S_^SU^dbQd Y^W e^eceQ\ TbUQ]c VQdYWeU e`cUd cd_]QSX ^QecUQ f_]Yd Y^W WQc TYQbbXUQ

One tablet, once daily, with a meal (200 mg of emtricitabine, 25 mg of rilpivirine, and 300 mg of tenofovir disoproxil fumarate)

BY\`YfYbY^U Yc Q^ >>BD9 dXU _dXUb S_]`_^U^dc >BD9c 3_] `\UbQ Yc _^\i V_b `QdYU^dc gX_ XQfU ^_d `bUfY_ec\i dQ[U^ Q^dY bUdb_fYbQ\ TbeWc Q^T XQfU Q fYbQ\ \_QT _V !

S_`YUc `Ub ]Y\\Y\YdUb _V R\__T _b \Ucc 4_ ^_d dQ[U gYdX ]UTYSY^Uc dXQd S_^dQY^ \Q]YfeTY^U 5`YfYb 5`YfYb 82F 5`jYS_] 3_]RYfYb Q^T DbYjYfYb _dXUb 89F Q^dYbUdb_fYbQ\ ]UTYSQdY_^c TbeWc d_ dbUQd cUYjebUc _b deRUbSe\_cYc `b_d_^ `e]` Y^XYRYd_bc ceSX Qc ;Q`YTUh _b 4UhY\Q^d 8Uc`UbQ CQY^d :_X^ºc g_bd _b ]_bU dXQ^ _^U T_cU _V TUhQ]UdXQc_^U EcU SQedY_^ gXU^ dQ[Y^W Q^dQSYTc Q^dYVe^WQ\ ]UTYSQdY_^c 8" bUSU`d_b Q^dQW_^Ycdc Q^dYRY_dYSc _b ]UdXQT_^U

=_cd cUbY_ec* ReY\Te` _V \QSdYS QSYT Y^ dXU R\__T cUfUbU \YfUb `b_R\U]c XU`QdYdYc 2 fYbec Y^VUS dY_^ ÃQbU e`c TU`bUccY_^ R_^U dXY^^Y^W Q^T SXQ^WUc Y^ dXU Y]]e^U cicdU] ?dXUb* Y^c_] ^YQ XUQTQSXU bQcXUc TYQb bXUQ ^QecUQ VQdYWeU TYjjY^Ucc TU`bUccY_^ QR^_b]Q\ TbUQ]c f_]YdY^W cd_]QSX _b _dXUb `QY^ Q^T c[Y^ TYcS_\_bQdY_^

SIDE EFFECTS

J U LY/A U G U S T 2 0 1 3 HIV plus

31

IJJILNOHCMNC= CH@?=NCIHM ;H> INB?L >LOAM MEDICATION TRADITIONAL DOSAGE

EGRIFTA

" ]W Y^ZUSdUT ceRSedQ^U_ec\i Zecd RU\_g dXU c[Y^ _^SU TQY\i

8U\`c bUTeSU 89F bU\QdUT UhSUcc RU\\i VQd Ri U^S_ebQWY^W dXU R_Ti d_ `b_TeSU ^QdebQ\ Wb_gdX X_b ]_^Uc dXQd bUTeSU VQd

4_ ^_d dQ[U YV i_e XQfU _b XQT YcceUc Y^f_\fY^W i_eb `YdeYdQbi W\Q^T YV i_e XQfU QSdYfU SQ^SUb _b YV i_e QbU `bUW^Q^d _b RbUQcd VUUTY^W

=_cd cUbY_ec* cUfUbU Q\\UbWYS bUQS dY_^ _b ÃeYT bUdU^dY_^ Y^ZUSdY_^ cYdU bUQSdY_^c _b Y^SbUQcU Y^ W\eS_cU Y^d_\UbQ^SU TYQRUdUc ?dXUb* @QY^ cgU\\Y^W ]ecS\U c_bU^Ucc dY^W\Y^W ^e]R^Ucc Q^T `bYS[Y^W ^QecUQ f_]YdY^W bQcX YdSXY^W

$ ]W dg_ _b V_eb dQR\Udc dXbUU dY]Uc TQY\i

DbUQdc Q^T XU\`c `bUfU^d bUSebbU^SU _V @^Ue]_SicdYc `^Ue]_^YQ Y^ 89F `_cYdYfU `QdYU^dc+ Q\c_ ecUT _^ _dXUb RQSdUbYQ\ Y^VUSdY_^c

DQ[U Qd dXU cQ]U dY]U UfUbi TQi Dbi ^_d d_ ]Ycc Q T_cU

=_cd cUbY_ec* c[Y^ bQcX Z_Y^d _b ]ecS\U QSXUc c_bU dXb_Qd _b VUfUb e^eceQ\ R\UUTY^W _b RbeYcY^W ?dXUb* TYjjY^Ucc ^QecUQ f_]YdY^W TYQbbXUQ \_cc _V Q``UdYdU VQdYWeU XUQTQSXU

?^U & ]W dQR\Ud UfUbi '" X_ebc _b " ]W _V _bQ\ c_\e dY_^ _^SU TQY\i

DbUQdc XU`QdYdYc 2

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34

HIV plus

J U LY/A U G U S T 2 0 1 3

MEDICATION

REBETOL bYRYfQbY^ CSXUbY^W =UbS[

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WHAT TO KNOW

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J U LY/A U G U S T 2 0 1 3 HIV plus

35

MEDICATION DOSAGE

WHAT IT DOES

WHAT TO KNOW

SIDE EFFECTS

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3_^dY^eUT _^ `QWU $( 36

HIV plus

J U LY/A U G U S T 2 0 1 3

THE 2013 COMPLETE HIV TREATMENT GUIDE

CHP?MNCA;NCIH;F G?>C=;NCIHM The medications used to treat HIV and all its complications went through extensive investigations and clinical trials before being approved for general use. Doctors are now working on vaccines and cures for HIV, utilizing everything from bone marrow transplants to injections of disease-killing cells. But there are even more promising advances coming from medical, university, and pharmaceutical organizations. Some of these new medications, which are not yet approved for use outside clinical trials, may soon be coming to a pharmacy near you.

NAME & MAKER

WHAT IT DOES

BMS-806 #SJTUPM .ZFST 4RVJCC

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TENOFOVIR ALAFENAMIDE (JMFBE 4DJFODFT

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37

THE 2013 COMPLETE HIV TREATMENT GUIDE // INVESTIGATIONAL MEDICATIONS NAME & MAKER

AMD070 (FO[ZNF

IBALIZUMAB 5BJ.FE APRICITABINE "WFYB -UE

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AMPLIGEN )FNJTQIFSY #JPQIBSNB

38

WHAT IT DOES

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CARRAGUARD 1PQVMBUJPO $PVODJM '.$ #JP1PMZNFS

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DEPAKENE "CCPUU -BCPSBUPSJFT

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HIV plus

ย J U LY/A U G U S T 2 0 1 3

THE 2013 COMPLETE HIV TREATMENT GUIDE

=IGJF?G?HN;LS ;H> ;FN?LH;NCP? G?>C=CH? The use of whatโ s called complementary and alternative medicine (CAM) is popular in the U.S., where yoga and massage have become mainstream activities. In fact, according to a study published in the journal AIDS Care, 60% of HIV-positive people have tried some form of CAM, most in addition to their antiretrovirals. While some CAMs have demonstrated bene๏ฌ ts, others are unproven and sometimes dangerous.

TREATMENT

WORTH IT?

ACUPUNCTURE

I5C

CHINESE BITTER MELON

=1I25

WHAT IT DOES

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COLLOIDAL SILVER

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MULTIVITAMINS

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REFLEXOLOGY

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SELENIUM

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SPIRULINA

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VITAMIN A

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ZINC

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never take these supplements without doctorโ s approval: sutherlandia, saint-johnโ s-wort, grapefruit, african potato, vitamin c, and garlic.

J U LY/A U G U S T 2 0 1 3 ย HIV plus

41

; MN;N?'<S'MN;N? AOC>? NI NB? ;C>M >LOA ;MMCMN;H=? JLIAL;G ";>;J# Don’t have deep pockets? The federally created, state-managed AIDS Drug Assistance Program (ADAP) can help people pay for their HIV medications.

The programs provide prescription medication to uninsured or underinsured people with HIV or AIDS. The requirements vary by state, but typically you have to be a resident, have HIV, and earn less than a certain amount per year, calculated as a percentage of the federal poverty level.

Below is a guide to ADAP income requirements, whether there is a waiting list to join, how many people are on it as of April (if available), and contact information. Each state’s Maximum Qualifying Income (MQI) to be in ADAP is shown as a percentage of the federal poverty level as well as the dollar amount for a one-person household (in the 48 contiguous states the federal poverty level for one person is $11,490; add $4,020 per family member).

ALABAMA GURcYdU* adph.org/aids @X_^U* (334) 206-5364 =A9* 250% or $28,725; GQYdY^W <Ycd* Yes, 27

IDAHO

ALASKA

ILLINOIS

GURcYdU* bit.ly/AKadap

(907) 263-2050 =A9* 300% or $43,050; GQYdY^W <Ycd* No

GURcYdU* bit.ly/illinoisADAP @X_^U* (217) 524-5983 =A9* 300% or $34,470; GQYdY^W <Ycd* No

ARIZONA

INDIANA

GURcYdU* bit.ly/AZadap @X_^U* (800) 334-1540 =A9* 300% or $34,470; GQYdY^W <Ycd* No

GURcYdU* bit.ly/indianaADAP @X_^U* (866) 588-4948 =A9* 300% or $34,470; GQYdY^W <Ycd* No

ARKANSAS GURcYdU* bit.ly/ARadap @X_^U* (501) 661-2408 =A9* 200% or $22,980; GQYdY^W <Ycd* Yes

IOWA

CALIFORNIA GURcYdU* bit.ly/CAadap @X_^U* (916) 449-5900 =A9* less than $50,000; GQYdY^W <Ycd* No

KANSAS

COLORADO GURcYdU* bit.ly/COadap @X_^U* (303) 692-2748 =A9* 400% or $45,960; GQYdY^W <Ycd* No

KENTUCKY GURcYdU* bit.ly/kentuckyADAP @X_^U* (866) 510-0005 =A9* 300% or $34,470; GQYdY^W <Ycd* No

CONNECTICUT GURcYdU* bit.ly/CTadap @X_^U* (800) 233-2503 =A9* 400% or $45,960; GQYdY^W <Ycd* No

LOUISIANA GURcYdU* hiv.dhh.louisiana.gov @X_^U* (504) 568-7474 =A9* 300% or $34,470; GQYdY^W <Ycd* Yes

DELAWARE GURcYdU* bit.ly/DEadap @X_^U* (302) 744-1050 =A9* 500% or $57,450; GQYdY^W <Ycd* No

MAINE

DISTRICT OF COLUMBIA GURcYdU* bit.ly/DCadap @X_^U* (202) 671-4900 =A9* 500% or $57,450; GQYdY^W <Ycd* No

MARYLAND GURcYdU* bit.ly/MDadap @X_^U* (800) 205-6308 =A9* 500% or $57,450; GQYdY^W <Ycd* No

FLORIDA

MASSACHUSETTS GURcYdU* bit.ly/MAadap @X_^U* (800) 228-2714 =A9* 500% or $57,450; GQYdY^W <Ycd* No

GURcYdU* floridaADAP.org @X_^U* (800) 352-2437 =A9* 400% or $45,960; GQYdY^W <Ycd* Yes, 22 GEORGIA

GURcYdU* bit.ly/georgiaADAP @X_^U* (404) 657-3100 =A9* 300% or $34,470; GQYdY^W <Ycd* No HAWAII

GURcYdU* bit.ly/hawaiiADAP @X_^U* (808) 733-9360 =A9* 400% or $52,920; GQYdY^W <Ycd* No

42

HIV plus

J U LY/A U G U S T 2 0 1 3

GURcYdU* safesex.idaho.gov @X_^U* (208) 334-6527 =A9* 200% or $22,980; GQYdY^W <Ycd* Yes, 14

GURcYdU* bit.ly/iowaADAP @X_^U* (515) 281-4775 =A9* 200% or $22,980; GQYdY^W <Ycd* No GURcYdU* bit.ly/kansasADAP @X_^U* (785) 368-8218 =A9* 300% or $34,470; GQYdY^W <Ycd* No

GURcYdU* bit.ly/MEadap @X_^U* (207) 287-3747 =A9* $55,850, add $3,960 per dependent; GQYdY^W <Ycd* No

MICHIGAN GURcYdU* michigan.gov/dap @X_^U* (888) 826-6565 =A9* 450% or $51,705; GQYdY^W <Ycd* No MINNESOTA GURcYdU* bit.ly/minnesotaADAP @X_^U* (800) 657-3761 =A9* 300% or $34,470; GQYdY^W <Ycd* No

THE 2013 COMPLETE HIV TREATMENT GUIDE MISSISSIPPI GURcYdU* bit.ly/mississippiADAP @X_^U* (601) 362-4356 =A9* 400% or $45,960; GQYdY^W <Ycd* No

PENNSYLVANIA

MISSOURI GURcYdU* bit.ly/missouriADAP @X_^U* (573) 751-6439 =A9* 300% or $34,470; GQYdY^W <Ycd* No

RHODE ISLAND GURcYdU* bit.ly/RIadap @X_^U* (401) 222-2320 =A9* 400% or $45,960; GQYdY^W <Ycd* No

MONTANA GURcYdU* bit.ly/montanaADAP @X_^U* (406) 444-4744 =A9* 330% or $37,917; GQYdY^W <Ycd* No

SOUTH CAROLINA GURcYdU* scdhec.gov/adap @X_^U* (803) 831-7806 =A9* 300% or $34,470; GQYdY^W <Ycd* No

NEBRASKA GURcYdU* bit.ly/NEadap @X_^U* (402) 559-4673 =A9* 200% or $22,980; GQYdY^W <Ycd* No

SOUTH DAKOTA GURcYdU* bit.ly/SDadap @X_^U* (605) 773-3737 =A9* 300% or $34,470; GQYdY^W <Ycd* No

NEVADA

TENNESSEE GURcYdU* bit.ly/TNadap @X_^U* (615) 532-2392 =A9* 300% or $34,470; GQYdY^W <Ycd* No

GURcYdU* bit.ly/nevadaADAP @X_^U* (775) 684-3499 =A9* 400% or $45,960; GQYdY^W <Ycd* No

GURcYdU* bit.ly/PennADAP @X_^U* (800) 922-9384 =A9* 337% or $38,721; GQYdY^W <Ycd* No

NEW HAMPSHIRE GURcYdU* bit.ly/NHadap @X_^U* (603) 271-4502 =A9* 500% or $57,450; GQYdY^W <Ycd* No

TEXAS

NEW JERSEY GURcYdU* bit.ly/newjerseyADAP @X_^U* (877) 613-4533 =A9* 500% or $57,450; GQYdY^W <Ycd* No

UTAH

NEW MEXICO GURcYdU* bit.ly/newmexicoADAP @X_^U* (505) 827-2433 =A9* 400% or $45,960; GQYdY^W <Ycd* No

VERMONT

NEW YORK GURcYdU* bit.ly/newyorkADAP @X_^U* (800) 542-2437 =A9* 435% or $49,981; GQYdY^W <Ycd* No

VIRGINIA

NORTH CAROLINA GURcYdU* bit.ly/NCadap @X_^U* (877) 466-2232 =A9* 300% or $34,470; GQYdY^W <Ycd* No

WASHINGTON GURcYdU* bit.ly/WAadap @X_^U* (360) 236-3426 =A9* 300% or $34,470; GQYdY^W <Ycd* No

NORTH DAKOTA GURcYdU* ndhealth.gov/HIV @X_^U* (701) 328-1059 =A9* 300% or $34,470; GQYdY^W <Ycd* No

WEST VIRGINIA GURcYdU* bit.ly/WestVAADAP @X_^U* (304) 232-6822 =A9* 400% or $45,960; GQYdY^W <Ycd* No

OHIO

GURcYdU* bit.ly/OHadap @X_^U* (866) 777-4775 =A9* 300% or $34,470; GQYdY^W <Ycd* No

WISCONSIN GURcYdU* bit.ly/WIadap @X_^U* (800) 991-5532 =A9* 300% or $34,470; GQYdY^W <Ycd* No

OKLAHOMA GURcYdU* bit.ly/OKADAP @X_^U* (405) 271-4636 =A9* 200% or $22,980; GQYdY^W <Ycd* No

WYOMING GURcYdU* bit.ly/WYadap @X_^U* (307) 777-5856 =A9* $38,300-$45,500, based on county; GQYdY^W <Ycd* No

GURcYdU* bit.ly/texasADAP @X_^U* (800) 255-1090 =A9* 200% or $22,980; GQYdY^W <Ycd* No GURcYdU* bit.ly/utahADAP @X_^U* (801) 538-6197 =A9* 250% or $28,725; GQYdY^W <Ycd* No GURcYdU* bit.ly/vermontADAP @X_^U* (802) 951-4005 =A9* 500% or $57,540; GQYdY^W <Ycd* No GURcYdU* bit.ly/virginiaADAP @X_^U* (866) 392-1309 =A9* 400% or $45,960; GQYdY^W <Ycd* No

OREGON

GURcYdU* bit.ly/oregonADAP @X_^U* (800) 805-2313 =A9* 200% or $22,980; GQYdY^W <Ycd* No

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J U LY/A U G U S T 2 0 1 3 ย HIV plus

43

MEDICATION

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DOSAGE

WHAT IT DOES

WHAT TO KNOW

SIDE EFFECTS

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48

HIV plus

J U LY/A U G U S T 2 0 1 3