BioScience Magazine Spring 2014 by Shannon Carr

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O K L A H O M A’ S

B I O S C I E N C E

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PRECISION MEDICINE OMRF Develops Innovative Approach to Attack Deadly Tumors

Oklahoma Proves the Sky’s the Limit in Bioscience Cultivation

GLOBAL REACH Caisson Biotech Signs $167 Million Deal with Novo Nordisk

IF YOU BUILD IT… Ardmore Houses a 40-Acre Technology Park Complete with 2,400 sq ft of Lab Space

OKLAHOMA BIO INDUSTRY DIRECTORY – MORE THAN 280 STRONG AND GROWING

We’re Proud to Help

We invite you to join us in our efforts! Contact us today.

Bill Burgess, Jr. Roundtable Chairman Vortex, Lawton

Our state is an emerging bioscience location offering signiﬁcant research infrastructure, business networking opportunities, a large talent pool and access to investment capital. We salute the work of OKBio and encourage you to meet the many bioscience companies who call Oklahoma home. We welcome your investment in our state!

Oklahoma Business Roundtable 655 Research Parkway, Suite 420 Oklahoma City, Oklahoma 73104 405-235-3787

www.okbusinessroundtable.com 2

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INSIDE PRESBYTERIAN HEALTH FOUNDATION 6 The Presbyterian Health Foundation plans to resume awarding grants to Oklahoma scientists and research organizations.

We’re Proud to Help

OKBio GROW!

We invite you to join us in our efforts! Contact us today.

Bill Burgess, Jr. Roundtable Chairman Vortex, Lawton

BREATHING EASY 7 Led by Oklahoma State University scientist Dr. Lin Liu, a formidable team of Oklahoma researchers has been assembled to study ways to treat respiratory infectious diseases.

The Oklahoma Business Roundtable is proud to partner with OKBio to help grow the bioscience community in our great state. The Roundtable serves as the state’s key economic development support organization. We are comprised of over 180 top Oklahoma corporate, education and research partners – all working together to advance business expansion, recruitment and new start-up opportunities. Our state is an emerging bioscience location offering significant research infrastructure, business networking opportunities, a large talent pool and access to investment capital. We salute the work of OKBio and encourage you to meet the many bioscience companies who call Oklahoma home. We welcome your investment in our state!

THRIVING BIOSCIENCE SECTOR 8 Oklahoma offers affordable, high-class facilities and a critical mass of bio researchers, companies and talent, all in one place. THE ULTIMATE PAIRING 10 The 2014 BioSummit delivered an important lesson of the critical pairing on scientist and entrepreneur required to advance a biotech concept. IF YOU BUILD IT... 12 Biotech companies in need of clean room space for R&D need look no farther than Ardmore, OK, where a 3,000-square-foot building with a 2,400-square-foot clean room awaits just the right tenant. A STRONGER STEM 14 Efforts to expose more students to career opportunities in science, technology, engineering and math is creating a brighter future for thousands of Oklahomans. OCAST SUPPORT FOR BIO 16 The Oklahoma Center for the Advancement of Science and Technology is all in with its support of biotech and the annual BIO show initiative by the Oklahoma Bioscience Association. SECRET OF THE ORCHID 19 Fungi found in the roots of a particular orchid may hold the key to advancing agriculture. PRECISION MEDICINE 20 The Oklahoma Medical Research Foundation has developed an innovative approach to research into cancer and finding new ways to attack deadly tumors. BUSINESS BIRTHPLACE 22 With seven colleges on one campus, the University of Oklahoma Health Sciences Center is a major contributor to the state's biosciences industry. OKLAHOMA BIOSCIENCE FACTS & STATS 30

Oklahoma Business Roundtable 655 Research Parkway, Suite 420 Oklahoma City, Oklahoma 73104 405-235-3787

OKLAHOMA BIO INDUSTRY DIRECTORY 32

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innovators & Entrepreneurs is produced by i2E, Inc., manager of the Oklahoma Technology Commercialization Center. For more information on any content contained herein, please contact i2E at 800-337-6822. © Copyright 2014 i2E, Inc. All rights reserved.

i2E TEAM

BOARD OF DIRECTORS

The i2E management and staff is composed of professionals with extensive experience

Howard G. Barnett, Jr., Chairman OSU-Tulsa, T OSU-CHS

in technology commercialization, business `iÛi « i Ì] Ûi ÌÕÀi ÛiÃÌ }] w > Vi] organizational. Scott Meacham President & CEO David Thomison Senior Vice President, Client Services Group Rex Smitherman Senior Vice President, Operations Sarah Seagraves Senior Vice President, Marketing Tom Francis Director of Funds Administration Josh O’Brien Director of Entrepreneurial Development Judy Beech Director of Finance Elaine Hamm Venture Advisor & Director, V Proof of Concept Center Shintaro Kaido Venture Advisor & Director, V Tulsa Immersion Program T Mark Lauinger Venture Advisor & Director, Tulsa Services V Richard Rainey Venture Advisor & Director, OSCR Program V Kenneth Knoll Venture Advisor & Director, Advisory Services V Scott Thomas IT Manager Michael Kindrat-Pratt Venture Advisor & Manager, V SeedStep Angels Jay Sheldon eMedia Specialist Jim Stafford f Communications Specialist Katelynn Henderson Events Specialist Cindy Williams Underwriting Specialist Jennifer Buettner Executive Assistant Kate Nelson Administrative Assistant

Craig Shimasaki Moleculera Labs Wes Stucky Development Management, Inc.

Stephen Prescott, Vice Chair OMRF

Roy H. Williams Greater Oklahoma City Chamber

Michael LaBrie, Secretary McAfee & Taft T

Richard Williamson T.D. Williamson T

Leslie Batchelor Center for Economic Development Law

Duane Wilson LDW Services, LLC

Robert Brearton American Fidelity Assurance Company Bill W. Burgess Vortex, Inc. V

PA R T N E R S Oklahoma Center for the Advancement of Science and Technology T (OCAST)

Michael Carolina OCAST

U.S. Economic Development Administration

Rita Combs REYAP Y Youth Programs

Greater Oklahoma City Chamber

Bob Craine TSF Capital, LLC

City of Oklahoma City

Steve Cropper

Oklahoma Business Roundtable

Philip Eller Eller Detrich, P.C. P

Oklahoma Medical Research Foundation

Carl Edwards Price Edwards Company, Oklahoma Business Roundtable, Presbyterian Health Foundation 5W\GVVG *CVƂGNF Crawley Ventures V

Brad Krieger Arvest Bank Philip Kurtz CareATC Hershel Lamirand III Capital Development Strategies Merl Lindstrom Phillips 66

American Fidelity Foundation Presbyterian Health Foundation

Oklahoma Manufacturing Alliance The Donald W. Reynolds Foundation The Oklahoma Experimental Program to Stimulate Competitive Research (EPSCoR) Oklahoma Department of Commerce U.S. Department of Treasury State Small Business Credit Initiative

Justin McLaughlin Tulsa Regional Chamber T Mary Mélon The Journal Record Fred Morgan The State Chamber David Myers Ponca City Development Authority David Pitts Stillwater National Bank Mark Poole First National Bank of Broken Arrow Meg Salyer ƂVVi > V > -Ì>vw } Darryl Schmidt BancFirst

www.i2E.org facebook.com/OKGOVCUP twitter.com/i2E_Inc

i2E TEAM

BOARD OF DIRECTORS

The i2E management and staff is composed of professionals with extensive experience in technology commercialization, business development, venture investing, finance, organizational.

Howard G. Barnett, Jr., Chairman OSU-Tulsa, OSU-CHS

Scott Meacham President & CEO David Thomison Senior Vice President, Client Services Group Rex Smitherman Senior Vice President, Operations Sarah Seagraves Senior Vice President, Marketing Tom Francis Director of Funds Administration Josh O’Brien Director of Entrepreneurial Development Judy Beech Director of Finance Elaine Hamm Venture Advisor & Director, Proof of Concept Center Shintaro Kaido Venture Advisor & Director, Tulsa Immersion Program Mark Lauinger Venture Advisor & Director, Tulsa Services Richard Rainey Venture Advisor & Director, OSCR Program Kenneth Knoll Venture Advisor & Director, Advisory Services Scott Thomas IT Manager Michael Kindrat-Pratt Venture Advisor & Manager, SeedStep Angels Jay Sheldon eMedia Specialist Jim Stafford Communications Specialist Katelynn Henderson Events Specialist Cindy Williams Underwriting Specialist Jennifer Buettner Executive Assistant Kate Nelson Administrative Assistant

Stephen Prescott, Vice Chair OMRF Michael LaBrie, Secretary McAfee & Taft

Craig Shimasaki Moleculera Labs Wes Stucky Development Management, Inc. Roy H. Williams Greater Oklahoma City Chamber Richard Williamson T.D. Williamson

Leslie Batchelor Duane Wilson Center for Economic Development Law LDW Services, LLC Robert Brearton American Fidelity Assurance Company Bill W. Burgess Vortex, Inc. Michael Carolina OCAST Rita Combs REYAP Youth Programs

PA R T N E R S Oklahoma Center for the Advancement of Science and Technology (OCAST) U.S. Economic Development Administration

Bob Craine Greater Oklahoma City Chamber TSF Capital, LLC City of Oklahoma City Steve Cropper Oklahoma Business Roundtable Philip Eller Eller Detrich, P.C. Oklahoma Medical Research Foundation Carl Edwards Price Edwards Company, Oklahoma Business Roundtable, Presbyterian Health Foundation Suzette Hatfield Crawley Ventures

American Fidelity Foundation Presbyterian Health Foundation Oklahoma Manufacturing Alliance

The Donald W. Reynolds Foundation Brad Krieger The Oklahoma Experimental Program to Arvest Bank Stimulate Competitive Research (EPSCoR) Philip Kurtz CareATC Oklahoma Department of Commerce Hershel Lamirand III Capital Development Strategies

U.S. Department of Treasury

Merl Lindstrom State Small Business Credit Initiative Phillips 66 Justin McLaughlin Tulsa Regional Chamber

ABOUT i2E Over our 15-year history, i2E’s nationally recognized services have provided business expertise and funding to more than 580 of Oklahoma’s emerging small businesses. With almost $50 million of investment capital under management, we are focused on serving companies in all phases of the business life cycle, from startups looking for their first round of capital all the way to established businesses seeking funding to expand their markets or products. We also are helping lead new business developments into the marketplace more efficiently and more quickly while providing guidance to bring more funding to Oklahoma’s researchers and entrepreneurs. In the past year we have launched several new initiatives that more quickly identify promising new technologies developed on state research campuses and working with new companies at the earliest stages of their development to identify a viable product and market. Finally, the Oklahoma Bioscience Association recently became part of i2E, a development that means we will carry on the organization’s mission of supporting and enhancing the biotechnology industry in Oklahoma. Through our proven business and venture development process, we turn ideas into successful enterprises ... i2E.

WHAT WE DO • Evaluate the potential of new concepts

Mary Mélon The Journal Record

• Assist with evaluation of business plans, marketing plans and raising capital

Fred Morgan The State Chamber

• Provide guidance in management team building, business structure and financial forecasting

David Myers Ponca City Development Authority

• Assist with developing an effective investor presentation

David Pitts Stillwater National Bank

• Assist in obtaining funding through federal grant programs

Mark Poole First National Bank of Broken Arrow Meg Salyer Accel Financial Staffing Darryl Schmidt BancFirst

www.i2E.org

facebook.com/OKGOVCUP twitter.com/i2E_Inc

• Work with research universities to encourage commercialization of technologies developed through research • Provide grant capital assistance & equity investment

Welcome from Scott Meacham Welcome to our readers, many of whom may be picking up a copy of i&E magazine for the first time. This publication is produced by i2E, Inc., which manages the Oklahoma Bioscience Association on behalf of its 32 sponsors across the state. This special edition focuses exclusively on the bioscience industry in Oklahoma with feature stories on some of the leading research institutions, support organizations and emerging companies in Oklahoma. I encourage you to take some time to browse the entire magazine and see what a difference this emerging industry is making in the lives of people and in Oklahoma’s economy. By some comparisons Oklahoma’s bio industry is small, yet it employs more than 51,000 Oklahomans. The heart of the bioscience industry is located on the Oklahoma Health Center campus in Oklahoma City, a 15-block area just east of downtown that boasts a diverse cluster of scientific research, education and health care organizations. Among the many organizations located on the Oklahoma Health Center campus are: The Oklahoma Medical Research Foundation, OU Medical Center, Children’s Hospital, the Oklahoma City Veteran Administration Hospital, the Dean McGee Eye Institute, the Peggy and Charles Stephenson Oklahoma Cancer Center, the Harold Hamm Diabetes Center, the Oklahoma Blood Institute and a host of educational institutions, including the University of Oklahoma College of Medicine. Located on the south end of the Health Center campus is the 21-acre University Research Park, a $100 million development that offers 700,000 square feet of class A office and wet lab space. Almost 40 emerging life science businesses are located in the park, along with a mix of support and educational organizations. The life sciences aren’t limited just to Oklahoma City, however. The bioscience “corridor” spans a large portion of the state, from Ardmore in Southern Oklahoma to Stillwater in the North Central section to Tulsa in the Northeast. You will find the stories of many of those organizations and businesses in the pages of this magazine. Finally, in the back of this edition of i&E magazine you will find an extensive list of bioscience-related organizations that call Oklahoma their home. I encourage you to use this as a reference for business contacts and future needs that you might have.

– Scott Meacham President & CEO Spring 2014 i&E

Sound Foundation Presbyterian Health Foundation to resume awarding grants to support biotech in Oklahoma

There is good news and there is better news for bioscience research in Oklahoma. The good news is that with the $85 million sale of the PHF Research Park to the University of Oklahoma in the Fall of 2013, the Presbyterian Health Foundation now controls an endowment of approximately $165 million dollars. The better news is that the Presbyterian Health Foundation is back in the business of making grants to support its mission of accelerating bioscience research discoveries into solutions that save and enhance human life. “Financially, the Foundation is in the strongest position it’s ever been,” said Carl Edwards, Presbyterian Health Foundation Chairman. “The sale has put us back into the grants business again in a major way.” As a nonprofit foundation, the PHF must distribute 5 percent of its endowment annually through charitable giving. For the Foundation, that will translate into grants that will benefit bioscience research in Oklahoma, particularly within the OU Health Center campus, where the renamed University Research Park is located. “We expect to be asked to make grants for any number of items relevant to research,” Edwards said. “This will be done through the University of Oklahoma Health Sciences Center, the Oklahoma Medical Research Foundation, the Dean McGee Eye Institute, and others, as well. “It could be funding chairs for professors they want to bring in or providing equipment for some of these professors. A lot of effort will be made to put together the type of financial package it will take to be able to recruit some of the top researchers in the country.” A brief history of the Presbyterian Health Foundation. The PHF was founded in 1985 as the result of the sale of the Presbyterian Hospital on the OU Health Center campus to the Hospital Corporation of America. Since 1985, Foundation has made grants totaling $116 million. In 1996, the Foundation began development of the PHF Research Park on the south end of the OU Health Center campus as a location for a science-based company spun out of an OU medical research laboratory.

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Supporting Medical Research in Oklahoma to Save and Enhance Human Life

In the ensuing years, the University Research Park has grown to seven buildings with more than 700,000 square feet of Class A wet lab and office space. It is home to 35 science based companies and numerous support organizations. Now that the sale of the Research Park is complete, the Foundation is out of the real estate business and putting its focus back on the business of awarding grants that will benefit bioscience research, Edwards said.

Dr. Jerry Vannatta, long-time faculty member and former dean of the OU College of Medicine, will chair a scientific subcommittee that will evaluate grant applications the Foundation receives. Tom Gray, a CPA who retired as managing partner with the professional services firm Grant Thornton, has been named interim President of the Foundation. Gray previously served in an advisory role for the Foundation on financial matters. As PHF Chairman, Edwards serves as a conduit for people seeking grants from the Foundation. “My day-to-day role with regard to the Presbyterian Health Foundation is to basically steer the various grant requests in the right direction and to represent the Foundation in discussions with the OU Health Center and all the different principals around here,” he said. “Obviously, I’m a good ear for people who are wanting grants.” Because it has a “carry-over” from previous charitable distributions, the Foundation has a few years before it has to resume distributing a full 5 percent of its endowment, Edwards said. However, the Foundation should resume making a limited number of grant awards before the end of the year. “The short and simple answer is that we are getting back into the grants business,” Edwards said. “We will start making them again in the next few months, probably sometime in the summer.” For more information on the Presbyterian Health Foundation, visit www.phfokc.com.

Sound Foundation

BREATHE EASY

Presbyterian Health Foundation to resume awarding grants to support biotech in Oklahoma There is good news and there is better news for bioscience research in Oklahoma. The good news is that with the $85 million sale of the PHF Research Park to the University of Oklahoma in the Fall of 2013, the Presbyterian Health Foundation now controls an endowment of approximately $165 million dollars. The better news is that the Presbyterian Health Foundation is back in the business of making grants to support its mission of accelerating bioscience research discoveries into solutions that save and enhance human life. “Financially, the Foundation is in the strongest position it’s ever been,” said Carl Edwards, Presbyterian Health Foundation Chairman. “The sale has put us back into the grants business again in a major way.” As a nonprofit foundation, the PHF must distribute 5 percent of its endowment annually through charitable giving. For the Foundation, that will translate into grants that will benefit bioscience research in Oklahoma, particularly within the OU Health Center campus, where the renamed University Research Park is located. “We expect to be asked to make grants for any number of items relevant to research,” Edwards said. “This will be done through the University of Oklahoma Health Sciences Center, the Oklahoma Medical Research Foundation, the Dean McGee Eye Institute, and others, as well.

Supporting Medical Research in Oklahoma to Save and Enhance Human Life

“My day-to-day role with regard to the Presbyterian Health Foundation is to basically steer the various grant requests in the right direction and to represent the Foundation in discussions with the OU Health Center and all the different principals around here,” he said. “Obviously, I’m a good ear for people who are wanting grants.” Because it has a “carry-over” from previous charitable distributions, the Foundation has a few years before it has to resume distributing a full 5 percent of its endowment, Edwards said. However, the Foundation should resume making a limited number of grant awards before the end of the year.

Thanks to a National Institutes of Health Centers of Biomedical Research Exis the top global burden of disease. It is a public health priority. The discovercellence (CoBRE) grant, Dr. Lin Liu is putting together an incredible foundaies that we will be able to investigate with this funding will address this need.” tion of researchers in the field of respiratory and infectious diseases. The grant is designed to allow junior faculty members to pursue re Liu is a Regents Professor, the Lundberg-Kienlen Professor in Biomedisearch careers, to create new jobs in Oklahoma and to build the research incal Research and director of the Lung Biology and Toxicology Lab in the Defrastructure that will enhance OSU’s research landscape. partment of Physiological Sciences at Oklahoma State University’s Center for “We are striving to renew the CoBRE grant and bring in another $11 Veterinary Health Sciences. He joined the veterinary center in 2000. million to Oklahoma at the end of the five-year funding,” says Liu. “To ac “When I interviewed for this job, complish this, we will create a critical “This is exciting, as we are making OSU people were talking about CoBRE. This mass of multidisciplinary investigators is exciting, as we are making OSU hisin the area of respiratory and infechistory with the first CoBRE grant awarded tory with the first CoBRE grant awarded to tious diseases by recruiting new faculty to Oklahoma State University.” Oklahoma State University,” says Liu. “The members and attracting existing faculty total funding approved is nearly $11.3 million over the five-year life of the grant.” members into the center. Liu is collaborating with four colleges from OSU (Arts and Sciences, “It is our hope to develop the Oklahoma Center for Respiratory and InAgricultural Sciences and Natural Resources, Center for Veterinary Health fectious Diseases into a nationally recognized research center that is the hub Sciences, and Engineering, Architecture and Technology), three colleges from for fostering interinstitutional collaborations, which will facilitate respiratory the University of Oklahoma (Medicine, Pharmacy, and Arts and Sciences), and infectious disease research in Oklahoma. My goal beyond the CoBRE and the Oklahoma Medical Research Foundation. grant is to establish a Life Science Research Institute with multiple research “The objective is to build up a critical mass of multidisciplinary investicenters housed in one new research building.” gators and research infrastructure to ultimately achieve research excellence in For more information on the Oklahoma Center for Respiratory and respiratory and infectious diseases,” adds Liu. “Respiratory infectious disease Infectious Diseases, visit https://ocrid.okstate.edu.

“The short and simple answer is that we are getting back into the grants business,” Edwards said. “We will start making them again in the next few months, probably sometime in the summer.” For more information on the Presbyterian Health Foundation, visit www.phfokc.com.

“It could be funding chairs for professors they want to bring in or providing equipment for some of these professors. A lot of effort will be made to put together the type of financial package it will take to be able to recruit some of the top researchers in the country.” A brief history of the Presbyterian Health Foundation. The PHF was founded in 1985 as the result of the sale of the Presbyterian Hospital on the OU Health Center campus to the Hospital Corporation of America. Since 1985, Foundation has made grants totaling $116 million. In 1996, the Foundation began development of the PHF Research Park on the south end of the OU Health Center campus as a location for a science-based company spun out of an OU medical research laboratory.

$11.3M research collaboration using animal models will benefit human respiratory patients

Led by Dr. Lin Liu, Oklahoma scientists are using a CoBRE grant to build a critical mass of multidisciplinary investigators in the area of respiratory and infectious disease.

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SCIENCE CLASS Oklahoma’s Thriving Bioscience Sector Supports Scientists, Entrepreneurs Left: Dr. Holly Van Remmen, Ph.D., Recently moved to Oklahoma to bring her two research projects into aging to the Oklahoma Medical Research Foundation as part of its free radical biology & aging research program. Photo provided by OMRF. Right: The nonprofit Oklahoma Medical Research Foundation is a key part of Oklahoma City’s biomedical research park and with more than 700 U.S. and international patents, it ranks among the nation’s leaders in patents per scientist. Photo provided by the Greater Oklahoma City Chamber.

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scientist, an entrepreneur and a company all are among those that have chosen Oklahoma as home because of its bioscience-related efforts. And with good reason. Oklahoma offers affordable, high-class facilities and a critical mass of bio researchers, companies and talent, all in one place. Scientist Holly Van Remmen recently chose Oklahoma City as the place to continue her research into the aging process, leaving the University of Texas Health Science Center in San Antonio, Texas, after about 30 years to join the Oklahoma Medical Research Foundation. Today, she has brought two research projects to OMRF and is a member of the Free Radical Biology & Aging Research Program at OMRF, looking into why people lose muscle mass and function as they age and at the role that mitochondria plays in the aging process. “At OMRF, it’s just such a great place to work if you’re a scientist,” Remmen, 54, said. “We’re still settling in, but so far everything has been a very positive experience. … I actually really like Oklahoma more than I thought I would.” Bioscience entrepreneur Clayton Duncan, a North Carolina native, also is on a list of people who have chosen to make Oklahoma City home. “There is a great spirit here,” Duncan said at a recent presentation to the Oklahoma Bioscience Roundtable. Duncan is founder and CEO of Accele Biopharma, Inc., and managing director of the companion Accele Venture Partners L.P., a venture capital fund. He first approached the University of North Carolina with his idea for a life science accelerator. But soon OMRF president Dr. Stephen Prescott persuaded him to look into establishing it in Oklahoma. He moved to the state in 2011. And in 2014, the fast-growing Cytovance Biologics, Inc., a leading full-service manufacturer of mammalian and microbial

biologics, announced plans for a multi-milliondollar expansion in Oklahoma City. The projects involve expanding its manufacturing operations by 10,000 square feet and good manufacturing practice (GMP) warehousing by 20,000 square feet of climate-controlled and monitored space. The bioscience sector in the Greater Oklahoma City region has estimated revenues of $4.1 billion and employs more than 27,800 workers with total compensation of $1.5 billion, according to studies in the last few years, and those numbers are growing. The jobs created or supported by the bioscience sector account for more than 6 percent of all employment in the region. In the mix of these successes is the Greater Oklahoma City Chamber. The Chamber is a leader in creating opportunities and access to resources for its bioscience companies and recently received the Hall of Fame Leadership Award for these efforts from the Oklahoma Bioscience Association. Through the years, the Chamber has played key roles in supporting development of Oklahoma City’s bio-research park, including the Presbyterian Health Foundation and a medical center that includes the University of Oklahoma Health Sciences Center, OMRF, the Dean McGee Eye Institute, the Children’s Hospital, the Veteran’s Administration Hospital and other organizations. The Chamber lobbies for legislation to support and protect Oklahoma’s bioscience industry and helped create a bioscience roadmap for the state with help and data analysis from the Battelle Technology Partnership Practice. For more information on the Greater OKC Chamber’s role in Oklahoma’s bioscience industry, contact Josh O’Brien, Director of Entrepreneurial Development at jobrien@okcchamber.com.

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Cytovance Biologics, a leading full-service contract manufacturer (“cmo”) of mammalian and microbial biologics, supports microbial fermentation up to 200L capacity. Photo by Cytovance Biologics.

Transmission electron micrograph of Baculovirus. This virus is commonly used to produce specific peptides and proteins by molecular biologists.

The thriving Oklahoma bioscience sector also counts as recent successes the research of several drug companies: Accele Biopharma, a bioscience business accelerator, has invested in: Pamlico Biopharma, which is developing an antibody mixture to treat pneumonia; Jortan, a promising diabetes technology founded using the research of Dr. Jordan Tang at OMRF; Synereca, which is creating a compound to fight drug-resistant bacterial infections; and Otologics, which is advancing a compound to protect people who are exposed to high decibels after a hearing loss. www.accelebio.com

Caisson Biotech, an Emergent Technologies portfolio company, just entered into a licensing deal with Novo Nordisk, which will be using Caisson’s drug delivery technology to develop drugs for diabetes and several other disease indications. Based on research of Dr. Paul DeAngelis, its chief scientific officer, Caisson has developed a drug delivery platform that uses a natural sugar polymer. www.caissonbiotech.com

Moleculera Labs, which recently closed a $700,000 investment round, has developed a series of tests called the Cunningham Panel, which predicts a patient’s likelihood of having Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococci known as PANDAS. www.moleculeralabs.com

Selexys Pharmaceuticals Corp. of Oklahoma City is developing treatments for inflammatory and thrombotic diseases, and announced it has entered a Phase 2 clinical trial for a new treatment invented in Oklahoma called SelG1, which targets sickle cell disease. In 2012, they completed a $23 million Series A Equity Financing Round led by MDM Capital and entered into an acquisition agreement with Novartis Pharmaceuticals with a potential value of $665 million. www.selexys.com

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THE ULTIMATE PAIRING:

Scientist and Entrepreneur An important lesson emerged for both entrepreneurs and scientists at the 2014 BioSummit held in April. They need each other. The theme of an entrepreneur-scientists pairing to build a company and carry a biotechnology toward the market surfaced time and again during the BioSummit, which was presented by the Oklahoma Bioscience Association. In his presentation that opened the BioSummit, i2E President and CEO Scott Meacham discussed the importance of thoroughly exploring a potential market for a new product and the “aha” moment that inventors often have in the process. “They think the world sees their mousetrap exactly as they do this way but they find out, ‘aha!’ the world really doesn’t see it that way,” Meacham told the BioSummit audience. “How do they get to that point as early as possible in the process? Is it a go or a no-go? Or does the concept need to go a different direction to gain market traction.” The Oklahoma Proof of Concept Center managed by i2E helps scientists reach those important conclusions before they spend hundreds of thousands of dollars and countless hours pursuing their dream of a business built around their discovery. But there also is the challenge of successfully executing on the concept. “You may have the best concept in the world, but you may not have the management talent around the idea to execute it,” Meacham said.

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i2E: Investing in Oklahoma Bioscience

THE ULTIMATE PAIRING:

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That’s where the marriage between scientist and entrepreneurs happens. Meacham pointed to Dr. Madeleine Cunningham at the University of Oklahoma who saw business potential in a series of test panels she developed that can diagnose neurological conditions in children known as PANDAS and PANS. Cunningham licensed the technology from OU and turned to veteran entrepreneur Dr. Craig Shimasaki to grow the concept into a successful business. Today, Oklahoma City-based Moleculera Labs has funding, customers and growing revenue from a market with pent-up demand. More examples of entrepreneur-scientist pairing emerged during the BioSummit. Clayton Duncan, CEO of Oklahoma City’s Accele Biopharma showed how his company provides both management and investment for biotech concepts, with four startups currently under management. The theme surfaced again during the final presentation of the day when San Francisco-based entrepreneur William Hagstrom made his “Building a Business Step by Step” presentation. In the 1990s, Hagstrom built Oklahoma Citybased Urocor into a successful, publicly traded diagnostic company. After stepping away from Urocor in the early 2000s, Hagstrom was sought out by Oklahoma Medical Research Scientist Dr. Michael Centola to help build a company called Riley Genomics, which had licensed an autoimmune technology Centola had developed at the OMRF. “I’m having lunch one day, sitting near the windows and minding my own business at the Presbyterian Health Foundation Research Park, and all of a sudden I hear ‘knock, knock, knock,’ ” Hagstrom said. “I look over and there’s Mike’s smiling face. He ran inside and said “we’ve got to talk.” The pairing ultimately resulted in a company that received critical funding from California investors, relocated to San Francisco, changed its name to Crescendo Bioscience and was acquired earlier this year for $270 million by Myriad Genetics. The payoff was spectacular for a company that found the right pairing of scientist and entrepreneur. But it’s also achieving the goal of making life better for millions of people who suffer from autoimmune disease. That’s the bottom line for everyone in the biosciences, Hagstrom said. “One of the things that is so wonderful about the field we are in, bioscience, biotech, is that it is all about human health; it’s all about making a difference; it’s about changing outcomes,” Hagstrom told the BioSummit audience. “It’s an awesome area to be involved in and one that we can have a great impact.” It’s also an industry that demonstrates the difference a successful partnership between scientist and entrepreneur can make for patients and investors alike.

Millions of people with challenging medical conditions around the world have hope for a healthy life, and that hope is found in bioscience research laboratories across Oklahoma. New therapeutics emerging from Oklahoma research promise relief from chronic pain or debilitating and life threatening illnesses. But the promising new technologies will never reach the millions of people who need it without the capital required to carry them through the long and expensive clinical trial process. New medicines have to prove themselves in multiple studies to be both safe and effective. For more than a decade, i2E has played a major role in helping Oklahoma researchers and entrepreneurs successfully cross the Valley of Death – that challenging period when no revenue is generated from sales. Through the funds under its management, i2E has invested more than $10 million in Oklahoma bioscience companies that are either developing new therapeutics or providing support for research and development. Companies in the i2E portfolio are advancing a diverse mix of medical solutions for specific conditions that range from inflammatory disease to macular degeneration to antibiotics to food safety, hearing loss, toxicology and much more. Even as these new technologies edge closer to bringing their life changing technologies to patients around the world, other promising discoveries continue to emerge from Oklahoma laboratories. Millions of dollars will be required to advance them to the market. In Oklahoma, many life science entrepreneurs will continue to turn to i2E for the critical seed funding needed to survive the initial stages of development. In the past year, i2E Inc. has invested over $2.1 million in 6 bioscience companies. The following is a look at some of the bioscience companies that i2E investments have supported over the years.

www.okbio.org www.i2E.org Spring 2014 i&E

Ardmore Development Authority creates tech park, lab space for potential biotechnology company

ARDMORE’S

Field of Dreams There’s a memorable scene in the movie “Field of Dreams” when Kevin Costner’s character stands in the middle of his Iowa corn field and sees a vision of a baseball park. A voice tells him “if you build it, they will come.” You know the rest of the story. A similar “if-you-build-it” scenario is playing out in the south central Oklahoma community of Ardmore. The Ardmore Development Authority (ADA) built a 3,000-square-foot facility complete with 2,400 feet of clean room/lab space that awaits a high tech tenant such as a biotechnology company. The building is located on a 40-acre technology park established by the Development Authority. “We have the ability to host small, startup technology companies through our emerging incubator and tech park,” said Brian Carter, interim CEO and President of the Ardmore Development Authority. “Our first facility is ready for occupancy.” Located in a rural area of Oklahoma midway between Dallas and Oklahoma City along I-35, Ardmore might appear to be as remote as Costner’s Iowa farm. But that’s where the similarities end. Ardmore is home to the Samuel Roberts Noble Foundation, the largest non-profit, independent agricultural research institute in the nation. The Noble Foundation employs almost 400 people, including 110 Ph.D. scientists, agricultural consulting and research associates who work to create new drought and disease-resistant plant varieties that improve forage for livestock around the world. “The Noble Foundation is truly an entity that sets Ardmore apart in terms of research and applied science potential,” Carter said. “We have an open and collaborative relationship for approaching prospective technology companies, offering incubator services and having a common vision for the type of biotech development we would like to see in our area.” In 2005, The Ardmore Development Authority, The Samuel Roberts Noble Foundation and the Southern Oklahoma Technology Center

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(SOTC) formed a partnership to create a business incubator facility, the Ardmore Technology Transfer Center, to recruit and retain technology oriented companies to Ardmore. The advantages to a tenant locating in the incubator include more affordable lease space and access to an array of on-site managerial, administrative and financial services that assist the companies in overcoming challenges faced in the market place. In addition, tenants are exempt from state tax liability on income earned on activities conducted at the incubator for up to 10 years. The ADA, with the help of the Noble Foundation, has established Ardmore as part of the Oklahoma Biotechnology Corridor which includes Stillwater and the Greater Oklahoma City Area. The potential for professional collaborations with the Noble Foundation also serves as an attraction to prospective companies. Representatives from both the Ardmore Development Authority and the Noble Foundation annually are among the OKBio contingent of approximately 80 Oklahomans who showcase the state at the BIO convention. Lesley Johnson, Director of Research and Development for the Ardmore Development Authority, has represented the city at the BIO show for the past three years. “For me on a personal level, the BIO show has been great for networking with other people in our state,” she said. “Those are people within Oklahoma who learn what Ardmore has to offer and might refer potential new businesses to us if they can’t accommodate their needs in their community.” Added Carter: “Our ultimate goal from participating along with our fellow Oklahomans at the BIO show would be forming a partnership that leads to investment and job creation in Southern Oklahoma.” It’s all part of a vision that says, “if you build it, they will come.” For more information contact Brian Carter at (580) 223-6162 or email: bcarter@ardmore.org

Ardmore Development Authority creates tech park, lab space for potential biotechnology company

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ARDMORE’S

Field of Dreams

Caisson Biotech signs $167 million licensing deal with Novo Nordisk

There’s a memorable scene in the movie “Field of Dreams” when Kevin Costner’s character stands in the middle of his Iowa corn field and sees a vision of a baseball park. A voice tells him “if you build it, they will come.” You know the rest of the story. A similar “if-you-build-it” scenario is playing out in the south central Oklahoma community of Ardmore. The Ardmore Development Authority (ADA) built a 3,000-square-foot facility complete with 2,400 feet of clean room/lab space that awaits a high tech tenant such as a biotechnology company. The building is located on a 40-acre technology park established by the Development Authority. “We have the ability to host small, startup technology companies through our emerging incubator and tech park,” said Brian Carter, interim CEO and President of the Ardmore Development Authority. “Our first facility is ready for occupancy.” Located in a rural area of Oklahoma midway between Dallas and Oklahoma City along I-35, Ardmore might appear to be as remote as Costner’s Iowa farm. But that’s where the similarities end. Ardmore is home to the Samuel Roberts Noble Foundation, the largest non-profit, independent agricultural research institute in the nation. The Noble Foundation employs almost 400 people, including 110 Ph.D. scientists, agricultural consulting and research associates who work to create new drought and disease-resistant plant varieties that improve forage for livestock around the world. “The Noble Foundation is truly an entity that sets Ardmore apart in terms of research and applied science potential,” Carter said. “We have an open and collaborative relationship for approaching prospective technology companies, offering incubator services and having a common vision for the type of biotech development we would like to see in our area.” In 2005, The Ardmore Development Authority, The Samuel Roberts Noble Foundation and the Southern Oklahoma Technology Center

Caisson Biotech, LLC recently announced a new $167 million-plus license agreement expanding scope for the use of Caisson’s HEPtuneTM patented heparosan-based drug delivery technology with its global partner, Novo Nordisk A/S (NYSE:NVO). Under this new agreement Novo Nordisk has exclusive rights to commercialize the HEPtune technology with insulin. Additionally, Novo Nordisk has licensed the non-exclusive use of the HEPtune delivery system within the fields of diabetes care products, human growth hormone therapy, treatments for obesity and for inflammatory diseases including Crohn’s, lupus, rheumatoid and psoriatic arthritis. Caisson is a biopharmaceutical company working to commercialize its HEPtune drug delivery system designed to improve the performance of drug compounds in terms of safety, tolerability, efficacy and quality. Caisson uses novel, heparosan-based conjugates to enhance the therapeutic properties of pharmaceuticals by increasing product half-life, reducing immunogenicity and increasing stability.

The pharmaceutical industry searches for safer, more effective solutions for delivering drugs. These solutions are needed because the physical, chemical, biological and even toxic nature of some drug compounds prevent safe delivery, cause unacceptable side effects or are eliminated too rapidly by the body to be effective unless administered in large, multiple doses. Caisson Biotech is a portfolio company of Emergent Technologies, Inc., an innovation solutions company that identifies, advances and partners to turn game-changing scientific discoveries into market-driven products. For more information contact Breca Tracy, Ph.D., at (512) 697-8195 or visit www.caissonbiotech.com.

Tommy Harlan, CEO of Emergent Technologies and Caisson Biotech (left), and Dr. Paul DeAngelis, Chief Scientific Officer of Caisson Biotech

“Our technology utilizes a naturally occurring sugar polymer that is stable and inert in the bloodstream, but is biodegradable inside cells for the purpose of cloaking, enlarging and/or protecting drug cargo.”

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Regents at the STEM of Bioscience Opportunities

he lives of thousands of young Oklahomans have changed dramatically, their potential soaring, their future brightened through emphasis by the Oklahoma State Regents for Higher Education to expose more students to career opportunities in the science, technology, engineering and mathematics (STEM) fields. The life sciences play a big role in STEM careers, and the State Regents have developed strategies to engage young people in STEM education as early as the seventh grade. A key example is the State Regents’ Summer Academies program, through which students can explore the latest trends in math, science and technology while experiencing life on a college campus.

Another area of emphasis for the State Regents is the importance of college completion, which has been identified as their top priority. As a result, the office of the State Regents is a founding member of the Complete College America (CCA) initiative. In the first year of CCA deployment, the number of degrees and certificates earned in Oklahoma increased by 2,945, which significantly exceeded the annual goal of 1,700. Through targeted investments in CCA initiatives that supported critical elements of student success, such as online education technology, concurrent enrollment, academic advisement, career counseling, financial aid and more, Oklahoma will continue to advance toward its goal of increasing the number of degrees and

Vonley Royal, OneNet Executive Director, was among the Oklahomans staffed the OKBio booth at the 2013 BIO show in Chicago. OneNet is a division of the State Regents that advances technology across Oklahoma with a mission of enhancing economic development by providing Internet access to education, researchers, communities and health care providers. Networking opportunities with other Oklahomans at the BIO show may be just as important as greeting visitors from around the world, Royal said. “I value the opportunity to engage with professionals from all areas of the state – research, health care, education and various levels of government – about initiatives within the state and around the country,” Royal said. “The professional networking relationships we’ve established are far-reaching and extremely valuable to OneNet’s efforts to serve the biotech community and support our state’s research institutions.” Of course, the BIO show provides a much larger audience with which to share OneNet’s story. “The conference also provides another avenue to promote OneNet’s mission of advancing technology in Oklahoma with new audiences around the world,” he said. For more information, visit www.okhighered. org. or just website address

A group of students from a summer STEM academy at the University of Central Oklahoma walk out toward their bus after touring a laboratory at the University Research Park. This academy is supported through a grant from the Oklahoma State Regents for Higher Education.

Additionally, the State Regents partnered with Gov. Mary Fallin’s office in 2013 to hold the first STEM Summit, a business and educator forum to advance STEM in Oklahoma. “The Oklahoma State System of Higher Education supports growing bioscience in Oklahoma,” said Dr. Glen D. Johnson, Chancellor of the Oklahoma State Regents for Higher Education. “From encouraging students at a young age to engage in science, technology, engineering and mathematics education to providing support to Oklahoma’s public colleges and universities where cuttingedge research is currently taking place, the State Regents will continue to help expand Oklahoma’s leadership role in the bioscience industry.”

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certificates by 67 percent by 2023. The State Regents also support Oklahoma’s economic development initiatives in the life sciences through participation in the state’s exhibition at the annual Biotechnology Industry Organization (BIO) convention. Representatives from the State Regents office are among the approximately 80 Oklahomans who showcase the state’s potential as a life sciences hotbed to thousands of BIO participants from around the world. The contingent of Oklahomans greeting visitors to the OKBio booth at the bio show bring a high level of expertise and diversity ranging from bioscientists to economic development professionals across the state.

Dr. Glen D. Johnson, Chancellor of the Oklahoma State Regents for Higher Education

Regents at the STEM of Bioscience Opportunities

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As Oklahoma’s only research-grade network, OneNet offers the high-speed connection Oklahoma’s researchers need for big data movement across the state and around the globe. OneNet services are available to research and education institutions, health care providers and public service agencies. We power Oklahoma State University and the University of Oklahoma as well as both health science centers. We invite you to learn more about how our leading-edge technology can empower your performance and meet your organization’s mission-critical needs.

Internet designed for research

Dr. Glen D. Johnson, Chancellor of the Oklahoma State Regents for Higher Education

888-5-OneNet • www.OneNet.net Winter 2014 i&E

The following OCAST programs and strategic partners are available to help Oklahoma businesses and researchers prove their ideas, attract additional funding and take their products to market. For more information on specific programs, contact OCAST at (866) 265-2215.

Oklahoma Applied Research Support (OARS): Cutting edge research leads to commercially successful products, processes and services. OARS funds research in all fields from medicine, agriculture and energy to manufacturing and nanotechnology. Oklahoma Health Research: Oklahomans are developing treatments and conducting research to help people live longer, healthier lives. OCAST funds research projects related to human health. Intern Partnerships: The Intern Partnership supports R&D projects that involve Oklahoma businesses and Oklahoma institutions of higher education by providing matching funds to support internship positions. Oklahoma SBIR Collaborative Resources (OSCR): The federal Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have complex application processes that can be challenging for small business owners and entrepreneurs. The OSCR program was created to improve the success rate of Oklahoma companies applying for the federal programs. Inventors Assistance Service (IAS)/New Product Development Center (NPDC): IAS helps inventors navigates the process of advancing an idea through education, information and referrals. Then the NPDC provides design, development, engineering and business support. Oklahoma Manufacturing Alliance: The Alliance connects Oklahoma manufacturers to cost-effective resources, more efficient manufacturing processes and technology to increase productivity and reduce costs. Oklahoma Seed Capital Fund: Managed by i2E, Inc., under a contract with OCAST, the Oklahoma Seed Capital Fund was created to invest in Oklahoma high-tech companies that need capital to grow their business. State dollars invested through the fund are matched with private sector co-investment.

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OCAST Supports BIO Conference Management and staff at the Oklahoma Center for the Advancement of Science and Technology (OCAST) can typically be found in attendance at annual BIO conferences whether in Boston, Chicago or Philadelphia. This year’s meeting in San Diego is no exception. Their purpose is the same as many Oklahomans in attendance - support the hundreds of biotechnology firms that call Oklahoma “home.” Biotech is in a growth mode in Oklahoma and support for the state’s biotech firms benefits the health and well-being of our citizens and advances Oklahoma’s economy through science and technology. “Support of BIO is an easy call for OCAST,” says Michael Carolina, executive director of the state’s technology-based science agency. “The life sciences and biotechnology are an integral part of the OCAST strategic plan. Our health research and applied research award cycles and award history are a strong signal that our efforts to help launch, support and sustain many of Oklahoma’s growth companies in biotech research are paying dividends—in terms of improved quality of life, economic development and jobs.” In concert with all of the participants, most notably the Greater Oklahoma City Chamber, OCAST staffers are prepared to share their time with other Oklahomans at the now very-familiar “Oklahoma” booth, a favorite stop for many attending the BIO event. Attendance ranges from 17,000 to 25,000 people from all around the globe. “In a spirit of cooperation with all the dedicated Oklahomans at BIO, we do not limit our assistance to OCAST clients only. Our staff is directed to assist anyone wanting to develop a business relationship with Oklahoma and our biotech companies. We are looking to facilitate licensing agreements, developing memos of understanding and explaining to booth visitors the benefits that our state makes available to any biotech firm choosing to locate in Oklahoma. “BIO is a place where huge networking occurs, business dates are scheduled and economic marriages are made – all in the interest of making Oklahoma’s economy stronger through biotechnology,” said Carolina. Each of the OCAST representatives who have attended one or more of past BIO events can relate stories of visitors from other states and nations who were complimentary of the level of competence and sophistication that can be found in Oklahoma’s biotechnology community. New stories will develop at the 2014 BIO conference in the same way as past events. Carolina said. “Soon after introductions are made, our visitors find themselves in deep deliberations with our biotech firms. Oklahoma’s booth is conducive to business arrangements and most Oklahoma biotech business owners are not bashful about what they bring to the table and what they need from others in the form of investment, intellectual property, access to out-of-state markets and other aspects of the industry.” Carolina said the programs and courses at BIO are an excellent opportunity to learn more about specific aspects of biotechnology, to share experiences and to learn of current and emerging industry best practices. “The focus on innovation, translational research and entrepreneurship is vitally important for researchers, biotech companies and those wishing to start biotech companies,” Carolina said.

Innovation

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A Proven Investment

Helping Oklahomans take their ideas to market every day.

(866) 265-2215

www.ocast.ok.gov

Small Business>>Bioscience>>Health>>Manufacturing>>Energy>>Environment>>Nanotechnology>>Internships

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Advancing Agriculture From the laboratory to the ﬁeld, The Samuel Roberts Noble Foundation drives innovation that advances agricultural productivity around the globe. Noble Foundation scientists explore the genetic networks of vital crops, and breed stronger, more efficient plants while the Noble Foundation’s team of agricultural experts offer knowledge and educational outreach to agricultural producers who face a world of rising challenges. Together, the men and women of the Noble Foundation address these challenges in ways that beneﬁt producers, society and the environment.

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www.noble.org | twitter.com/NobleFoundation facebook.com/NobleFoundation

An Orchid by Any Other Name Fungi found in the roots of a particular orchid may hold the key to advancing agriculture The delicate pastel petals of the orchid have a lot in common with the rugged, rangy switchgrass of the great plains – at least in Kelly Craven’s laboratory. Craven, Ph.D., an associate professor at The Samuel Roberts Noble Foundation in Ardmore, OK, is exploring the idea of enhancing the growth of switchgrass with the fungi that dwell in the roots of an orchid, which co-exist in a relationship that benefits both plant and fungus.

Sebacinales order). Recent research conducted by outside laboratories suggested these fungi may have the ability to interact with many plants instead of being orchid-specific. Craven successfully transferred the fungi to switchgrass, proving just how adaptable these particular orchid fungi can be. Additionally, the results revealed that the fungi-infused switchgrass had three times the biomass. But, switchgrass was just the beginning. “We can take the orchid fungi and infect every plant we’ve tried so far,” Craven said. “That includes Arabidopsis thaliana, a plant species that even arbuscular mycorrhizae (AM), renowned for their broad host range, cannot colonize.” A. thaliana belongs to the plant family Brassicaceae, whose members typically lack key genes that are known to regulate symbiosis with both AM fungi and nitrogen-fixing bacteria (Rhizobia). “The fact that we can infect A. thaliana with these orchid fungi suggests that they colonize the roots through an entirely different pathway than either AM fungi or rhizobia” Craven said. “That’s a fascinating aspect of the basic biology that may

Principal Investigator Kelly Craven, Ph.D., (right) examines orchids in the Noble Foundation greenhouse with Postdoctoral Fellow Prasun Ray, Ph.D.

Advancing Agriculture From the laboratory to the field, The Samuel Roberts Noble Foundation drives innovation that advances agricultural productivity around the globe. Noble Foundation scientists explore the genetic networks of vital crops, and breed stronger, more efficient plants while the Noble Foundation’s team of agricultural experts offer knowledge and educational outreach to agricultural producers who face a world of rising challenges. Together, the men and women of the Noble Foundation address these challenges in ways that benefit producers, society and the environment.

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www.noble.org | twitter.com/NobleFoundation facebook.com/NobleFoundation

Expanding this naturally occurring symbiotic relationship to other plants could enhance their growth, increase crop yield, and improve productivity and crop economics. The impact could be a boon to both food sustainability and the energy sector. In one particular application, a switchgrass-fungi combination might enhance the economics of this crop, making it more productive and less costly to refine into advanced biofuels. “In the next century, we have to produce more with less: less arable land, less water and less fertilizers,” Craven said. “In combination with plant breeding approaches at the Noble Foundation, we’re developing plants that have higher yields or grow better under a greater variety of environmental conditions. Mother Nature has already provided us examples through some of these symbiotic relationships. Now we want to use them in new crops.” That’s where the delicate orchid comes into play. Different orchids rely extensively on fungi enmeshed in their roots. Some use it to help perform fundamental processes like germinating seeds while others use it to provide carbon until they are capable of photosynthesis. In extreme cases, some orchids remain incapable of photosynthesis for their entire lifespan, and the fungus is their sole provider of carbon. As part of his research, Craven’s laboratory pinpointed a particular group of orchid fungi (the

THE SAMUEL ROBERTS NOBLE FOUNDATION is an independent, nonprofit institute headquartered in Ardmore, Okla. Founded in 1945, the Noble Foundation conducts direct operations, including assisting farmers and ranchers, and conducting plant science research and agricultural programs, to enhance agricultural productivity regionally, nationally and internationally. The Noble Foundation, is the largest private foundation in Oklahoma and is in the top 44 in the United States (based on asset size). Employs more than 350 individuals, including more than 90 Ph.D. scientists, agricultural consultants and research associates. Hosts a large international population, including employees from more than 20 countries and six continents. Houses 21 primary research laboratories focused on plant research. Operates a 500,000-square-foot central campus having research, program, infrastructure and administrative space. Operates more than 12,000 acres of farms in southern Oklahoma for research and demonstration projects. Assists more than 1,700 farmers and ranchers in a 47-county service area (southern Oklahoma and north Texas) in achieving their individual financial, production, stewardship and quality-of-life goals.

The fungus that naturally occurs in orchids, such as this one, has been successfully transferred to switchgrass, resulting in increased biomass.

ultimately challenge notions of how plants enter into symbiosis, and also open up new avenues for incorporation of these partnerships into new agricultural crops.” There also is the broader potential application for the orchid fungi. Craven has initiated a study of their impact on valuable food crops like wheat, oats and soybeans. So far, the findings have been encouraging. Craven’s team has been able to colonize each of the crops. Among its many positive attributes, these fungi serve as an extension of the plant’s root system, helping to improve the nutrient acquisition from the soil and sustain growth.

Prasun Ray, Ph.D., cuts Medicago truncatula, which hosts a beneficial fungus being studied.

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JONESING FOR THE CURE A Dr. David Jones is building a new

kind of cancer-fighting machine at the

Oklahoma Medical Research Foundation

The zebrafish model enables researchers not only to identify genes that might underlie human disease, but also to develop novel therapeutic agents in drug discovery programmes programmes. Zebrafish embryos have proven to be a rapid, cost-efficient, and reliable teratology assay model.

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former senior research scientist and program leader for Pharmacia and Upjohn, Inc., David Jones is a veteran of the pharmaceutical industry. But he has also spent nearly two decades leading a lab at the University of Utah’s Huntsman Cancer Institute, where he served as Senior Director of Early Translational Research. As the new head of OMRF’s Immunobiology and Cancer Research Program, Jones is building a team of like-minded researchers with a focus on translational research. Thanks to a partnership with the Peggy and Charles Stephenson Cancer Center at the University of Oklahoma, Jones and OMRF are attracting a new generation of scientists who want to take new discoveries to patients. “We think of it as ‘precision medicine,’” Jones says. “We want to use the technologies at our disposal to more precisely understand the cause of a disease in a patient and then find the tools that will be most effective in their treatment.” To that end, OMRF recruited an expert in cancer xenografts, the ability to grow a patient’s tumor in a mouse, giving researchers and clinicians a way to test experimental therapies. “We’ll be able to choose from a menu of treatments that best align with a patient’s genetic profile,” Jones says. “But it will also give us leads on research that can grow that menu.” Using molecular analysis, OMRF leverages high-throughput technologies to profile the unique make-up of DNA, RNA and proteins in tumors. “This creates a flood of data that can sometimes tell us how to treat a tumor,” he says. “Many times, however, we need to do more work to understand the message. To accomplish this, OMRF has positioned itself to advance techniques of biology to match the flood of high-throughput molecular data.” Working with collaborators to find new cancer-associated genes, Jones’ lab uses quick-breeding and transparent zebrafish to test new ideas about the causes of cancer and potential new treatments. The fish are an inexpensive and easy first step in finding new ways to diagnose and treat cancer, Jones says, acting as a kind of screening process to help narrow the field of relevant targets as scientists search for answers. “Researchers can take 1,000 possible cancer-related mutations and winnow them down to 50 for testing in mice, then reduce that number further in xenografts,” Jones says. The remaining relevant genetic mutations will be targets for new drugs. Jones and other OMRF scientists employ a high-throughput drug screening process to test compounds for use in a variety of diseases. Already, Jones has drugs to treat colon cancer in the development pipeline. “The best part is that this system will work for other diseases such as autoimmune diseases, heart disease and more,” he says. “We’re putting a system in place where we can analyze every stage of disease development and more precisely identify treatments to improve patient care.” For more information, visit www.omrf.org.

JONESING FOR THE CURE A Dr. David Jones is building a new

kind of cancer-fighting machine at the

Oklahoma Medical Research Foundation

The Oklahoma Medical Research Foundation based in Oklahoma City, employs 427 people, including 121 Ph.D. scientists who conduct research in: CANCER CARDIOVASCULAR DISEASE MULTIPLE SCLEROSIS LUPUS DEVELOPMENTAL BIOLOGY AGING

in tumors. “This creates a flood of data that can sometimes tell us how to treat a tumor,” he says. “Many times, however, we need to do more work

The zebrafish model enables researchers not only to identify genes that might underlie human disease, but also to develop novel therapeutic agents in drug discovery programmes. Zebrafish embryos have proven to be a rapid, cost-efficient, and reliable teratology assay model.

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to understand the message. To accomplish this, OMRF has positioned itself to advance techniques of biology to match the flood of high-throughput molecular data.” Working with collaborators to find new cancer-associated genes, Jones’ lab uses quick-breeding and transparent zebrafish to test new ideas about the causes of cancer and potential new treatments. The fish are an inexpensive and easy first step in finding new ways to diagnose and treat cancer, Jones says, acting as a kind of screening process to help narrow the field of relevant targets as scientists search for answers. “Researchers can take 1,000 possible cancer-related mutations and winnow them down to 50 for testing in mice, then reduce that number further in xenografts,” Jones says. The remaining relevant genetic mutations will be targets for new drugs. Jones and other OMRF scientists employ a high-throughput drug screening process to test compounds for use in a variety of diseases. Already, Jones has drugs to treat colon cancer in the development pipeline. “The best part is that this system will work for other diseases such as autoimmune diseases, heart disease and more,” he says. “We’re putting a system in place where we can analyze every stage of disease development and more precisely identify treatments to improve patient care.” For more information, visit www.omrf.org.

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s an academic medical center with seven colleges on one campus, the University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City is a major contributor to the state’s biosciences industry. In 1998, Oklahoma passed legislation that allows university research to be commercialized, and since that time, many OUHSC projects have been transformed into start-up companies across the state. Several companies got their start with OUHSC research and have since attracted millions in state and federal funding. Promising examples include the companies Selexys, which is creating a drug for sickle cell disease; Heparinex, which produces recombinant technologies for biopolymers; and DormaTarg, which identifies drugs that can safely prevent cancer recurrence. State-of-the-art facilities, both on the OUHSC campus and at community partner sites, demonstrate that the state takes seriously the role of biosciences in its future.

understanding health and disease. It also aims to increase research performed by clinically trained investigators, and to help translate research findings into clinical practice. The award will create a research, education and training home at OUHSC called the Oklahoma Shared Clinical and Translational Resources (OSCTR) program, which forges partnerships between 10 Oklahoma institutions, physicians across the state, American Indian tribes throughout Oklahoma and Kansas, and others. Efforts will target multiple patient populations, including those in rural parts of Oklahoma that are often underserved in the health care arena. That award came on the heels of two other large NIH grants awarded to OUHSC in 2012, each for $10 million. Those grants, called CoBRE (Center of Biomedical Research Excellence), allow cancer researchers and diabetes researchers to mentor junior investigators in diverse projects. Many of those junior researchers go on to become independent NIH-funded investigators.

In the last five years, 104 patents have been issued to OUHSC. That’s a number that speaks to the dedication and skill of researchers who carry out their groundbreaking work in laboratories across campus every day. Research areas are wide-ranging, including diabetes, cancer, vision and neuroscience, infectious diseases, autism, tobacco use prevention, and much more. In September 2013, the campus received the largest NIH grant in state history, in collaboration with the Oklahoma Medical Research Foundation. The $20.3 million, five-year grant will provide investigators with multifaceted support for taking discoveries from “the bench to the bedside.” The grant marks a national focus to increase clinical and translational research, which is of critical importance to

OUHSC also has experienced a successful year in recruiting new researchers to campus. Three top scientists who joined the Stephenson Cancer Center in 2013 brought $7.7 million in new research funding to the campus and potentially millions more to the state’s economy. OUHSC’s commitment to research grows stronger each year, and as a teaching facility, students begin their careers with significant exposure to all that research offers. That focus continues to translate into more Oklahoma bioscience and job creation that will bolster the state’s economic future. For more information about research endeavors at the OU Health Sciences Center, call the Office of Research Administration at (405) 271-2090 or visit http://research. ouhsc.edu.

A new, greatly expanded Core Genetics Laboratories at the OU Health Sciences Center opened in 2013, giving physicians and researchers the ability to discover and study more genetic conditions. Here, laboratories director Shibo Li, M.D., back, joins Yuting Dai, M.D., in looking at a genetic testing image.

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TCC BIOTECHNOLOGY PROGRAM CHARTS ROAD TO SUCCESS FOR GRADS Tulsa Community College continues its mission of providing accessible, affordable higher education opportunities by investing in its Biotechnology Program. Successes are evident both within the College and beyond as TCC cultivates internships for TCC Biotechnology students and graduates across the state in both industry and research; offers outreach and training opportunities for high school students and teachers; and offers summer research courses in Biotechnology education. TCC’s Biotechnology Program has earned a reputation for its excellence. Students as well as graduates from the program enjoy infinite career and research possibilities within the field of biotechnology. Experienced instructors, state-of-the-art equipment and four different levels of internships prep them for scientific discovery. Student success stories continue to unfold as the Biotechnology Program matures at TCC. In fall 2013, students in the program were awarded internships in area academic labs of Oklahoma State University, OSU Center for Health Sciences, the University of Oklahoma, and Northeastern State University, while students had received intern placements in a national lab and an NSF/REU lab. Forty-three percent of the students completing the program by spring of 2012 have either entered medical school or bioscience graduTwo TCC Biotechnology students, left, assist high school ate studies. students during the 2012 Biotechnology Extravaganza. STUDENTS SELECTED FOR PAID SUMMER INTERNSHIPS Several Tulsa Community College students, majoring in either biology or biotechnology, will spend this summer doing paid internships in area research labs. Bobby Daugherty, Minji Sohn, Mang Chang, Heba Hammami and Hunter Bearden will earn $5,000 each for completing internships through the Oklahoma IDeA Network of Biomedical Research Excellence (OK-INBRE). Jeremy Sabo, Andrew Brown and Mylissa Stover will earn $1,000 for completing internships through Tulsa Area Bioscience Education & Research Consortium (TABERC). These awards allow the students to experience authentic research as well as learn the activities that occur in area research bioscience labs.

Front row: Professor Dusti Sloan, Jeremy Sabo, Bobby Daugherty, Minji Sohn, Mang Chang, Andrew Brown; Back row: Professor Bill Briscoe, Heba Hammami, Mylissa Stover, Professor Diana Spencer, Hunter Bearden

For more information about TCC’s Biotechnology Program, contact:Diana Spencer, PhD Biotechnology Coordinator DSpencer@tulsacc.edu

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CAPITAL, MANAGEMENT FOR LIFE SCIENCE COMPANIES Accele Biopharma (“Accele”) and Accele Venture Partners 1 LP, a related special purpose venture fund, were formed to create a capitalefficient mechanism to identify, finance and manage groundbreaking, early-stage life science technologies that have the potential to dramatically improve human healthcare, have strong commercial promise and have the potential for generating early proof of concept data. To achieve this goal Accele has assembled an experienced management team, a group of sophisticated investors, a nationally recognized advisory board, leading research facilities and the broad scientific expertise necessary to evaluate and manage such opportunities. Founded in 2011, Accele is located on the Oklahoma Health Center campus in Oklahoma City. For more information on Accele Biopharma, please visit www.accelebio.com.

ADVANCING TREATMENT FOR SICKLE CELL DISEASE Selexys is a privately held clinical development company advancing novel therapeutics for the treatment of inflammation, thrombosis and metastasis across a broad range of severe diseases. On August 19, 2013 Selexys initiated the SUSTAIN trial, a Phase II, multicenter, randomized, placebo-controlled, double-blind, 12-month study to assess safety and efficacy of the antiP-selectin monoclonal antibody SelG1 with or without hydroxyurea therapy in sickle cell disease patients with sickle cell-related pain crises. The study will examine the effectiveness of SelG1 in reducing the rate of sickle cell-related pain crises in each active dose level as compared to placebo. Further information on this trial is available at clinicaltrials.gov (NCT01895361). Selexys is also developing other novel treatments for Crohn’s disease, multiple myeloma, and other inflammatory disorders. In 2012, Selexys completed a $25 million Series A financing led by MPM Capital and an option agreement with Novartis Pharmaceuticals to acquire SelG1 following the SUSTAIN study. www.selexys.com

For more information about TCC’s Biotechnology Program, contact:Diana Spencer, PhD Biotechnology Coordinator DSpencer@tulsacc.edu

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The Smartest Grid In The World How Oklahoma Gas & Electric harnessed innovation and technology to bring power to the people In 2007, OGE Energy Corp. Chairman, President and CEO Pete Delaney put a stake in the ground for his company — OG&E will defer the building of any incremental fossil-fueled power generation until at least 2020. That declaration became known as the 2020 plan and would be the genesis of an extraordinary paradigm shift for OG&E customers. The plan would save ratepayers and shareholders money by shifting their peak energy use to offpeak hours, but achieving that goal meant undertaking the huge task of building a smart grid and developing technology to empower customers to take control of their energy use. Advanced Metering Infrastructure, which came to be called Smart Grid, had been introduced in many parts of the country already, but not without problems. OG&E’s smart grid team conducted extensive research and community pilots before officially embarking upon the largest initiative in its history. In just three years, the company installed more than 823,000 smart meters across its 30,000-square-mile service territory and launched a near real-time energy management website so all customers could monitor their energy use. In 2012, OG&E introduced SmartHours, a voluntary pricing program. SmartHours is a variable price rate plan with significantly reduced off-peak pricing and variable peak pricing during summer months. More than 40,000 customers signed up the first year, many receiving a free programmable communicating thermostat that allows them to save even more. Today, customers are reducing their peak energy use and enjoying the savings that comes along with helping to defer the need to build a

Oklahoma is the fertile ground of bio-innovation

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new power plant. And the energy industry has taken notice. OG&E’s smart grid project has garnered top industry recognition and awards, including being named the top smart grid in the world by the Smart Grid Global Impact Report. But the larger achievement is innovation – in strategy and technology. Using smart grid technology to partner with customers has put OG&E in reach of its 2020 goal. www.oge.com

Spring 2014 i&E

PURE DISCOVERY

OU researcher Dr. William Hildebrand develops platform technology that targets cancer, infectious diseases

ure MHC, LLC, is a platform technology company that combines disease specific target identification with antibody drug discovery for cancer, infectious, and autoimmune diseases. Pure MHC leverages the same disease targets in drug discovery that the immune system uses to identify aberrant proteins in cancerous and infected cells. The immune system must have a way to sample all the proteins that are expressed inside a cell to find those proteins that might be the result of tumor transformation or pathogen infection. This is especially important if these proteins never make it past the plasma membrane. HLA is the protein array technology the immune system uses to allow for immune surveillance of intracellular proteins. All nucleated cells express HLA class 1 and HLA has a groove that allows for peptide binding. HLA is a transmembrane protein that displays on the surface a peptide fragment of every protein

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that is either synthesized or degraded inside any particular cell. T cells survey every HLA-peptide combination on every cell to determine if a particular peptide is aberrant and likely the result of cancer or infectious disease. If so, it kills that cell. Pure MHC has developed a platform technology that allows for the expression of a pure source of HLA (MHC) and all the peptides represented in a particular cell. Using the most sensitive mass spectroscopy techniques Pure MHC can compare the peptides from cancer, infected, and normal cells and determine with high confidence which peptides represent disease targets. Once identified, Pure MHC â&#x20AC;&#x153;drugsâ&#x20AC;? the unique peptide-HLA disease targets with monoclonal antibodies. In vivo, peptide-HLA complexes are recognized by T cell receptors. Because these antibody drugs recognize the same exact targets as T cells they are called T cell receptor mimics (TCRm). The Pure MHC platform technology al-

lows for the identification of targets and development of antibody therapeutics and companion diagnostics for multiple cancers and infectious diseases. Soluble HLA (sHLA) is the key enabling technology that drives Pure MHC disease target identification and was developed by Professor William Hildebrand at the University of Oklahoma HSC. Pure MHC is funded and managed by Emergent Technologies, Inc. an innovation solutions and technology commercialization company headquartered in Austin, Texas (www.emergenttechnologies.com). To learn more about Pure MHC visit www. puremhc.com or contact Gregory Frank, PhD at (512) 697-8157 or gregory.frank@etibio.com

OK LIFE SCIENCE FUND PROVIDES CAPITAL TO HELP GROW BIOSCIENCE COMPANIES IN OKLAHOMA The Oklahoma Life Science Fund (OLSF) was formed in 2000 to take advantage of venture capital investment opportunities in the Oklahoma life sciences. With more than $15 million in assets under management, OLSF seeks to support local entrepreneurs and developing technologies from Oklahoma’s premier research institutions by providing them with a company building pathway, investment capital, and access to our national network of business contacts and venture capital firms. Since its inception, OLSF has started and invested in eleven Oklahoma startups within the pharmaceutical, healthcare device and diagnostic, and healthcare service industries. Our portfolio companies have attracted more than $20 of out of state venture capital for every dollar OLSF has invested, translating into nearly $300 million invested directly into OLSF portfolio companies. The capital injections into OLSF portfolio companies have paved the way for future life science innovation in the state, as OLSF has established a company building process for their portfolio companies and exposed the local startup scene to notable out of state funding sources such as Khosla Ventures, New Enterprise Associates, Clarus Ventures, Sanderling Ventures, CenterPoint Ventures, Prolog Ventures, Qualcomm Ventures, MPM Capital, Eli Lilly, Novartis, and many more. Many of these entities have invested into multiple OLSF portfolio companies. www.olsfventures.com

PURE DISCOVERY

FINDING SOLUTIONS Once a month members of the bioscience community meet in Oklahoma City to collaborate, share collective knowledge and insight, and address challenges the industry faces. Welcome to the Bioscience Roundtable, which serves as a sounding board to air and identify common issues that challenge emerging Oklahoma life science companies and research organizations. Roundtable discussion focuses on finding solutions and policy recommendations and as a vehicle for sharing resources. “How can we move research forward?” said Deborah Moorad-Watts, Bioscience Roundtable Chairman for 2014. “What would be a good sounding board?” Moorad-Watts is Director of Corporate and Foundation Relations for the Oklahoma State University Foundation and a consultant for bioscience companies. Program chairs Madison Jackson (VADovations, Inc.) and Carol Curtis (EpimedX, LLC), along with Moorad-Watts, are charting a fresh course for the organization that will be inclusive of all Oklahoma-based bioscience organizations. There are common issues that challenge everyone, Moorad-Watts said. The Bioscience Roundtable will address the challenges and brainstorm possible solutions. “We’re trying to build collaboration among the Oklahoma bioscience community,” she said. For more information on the Bioscience Roundtable, contact Deborah Moorad-Watts at dwatts@osugiving.com.

THE DERMAMEDICS DIFFERENCE DermaMedics is a skin care company that specializes in the discovery of technologies for the dermatology market. DermaMedics has broad expertise in molecular based skin research and uses this expertise to identify botanically derived chemical compounds that display pronounced biological activities that are beneficial to the skin. Dermamedics’ skin biochemistry research program originated at the University of Oklahoma Health Sciences Center and the discoveries made there were transferred to the company in 2011. Through licensing agreements, DermaMedics makes its patented technologies available to pharmaceutical companies that specialize in dermatology product development. In addition, DermaMedics utilizes its expertise in skin science to develop novel skin care products that are specifically designed for the physician and other medical professionals. www.dermamedics.com

OU researcher Dr. William Hildebrand develops platform technology that targets cancer, infectious diseases

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that is either synthesized or degraded inside any particular cell. T cells survey every HLA-peptide combination on every cell to determine if a particular peptide is aberrant and likely the result of cancer or infectious disease. If so, it kills that cell. Pure MHC has developed a platform technology that allows for the expression of a pure source of HLA (MHC) and all the peptides represented in a particular cell. Using the most sensitive mass spectroscopy techniques Pure MHC can compare the peptides from cancer, infected, and normal cells and determine with high confidence which peptides represent disease targets. Once identified, Pure MHC “drugs” the unique peptide-HLA disease targets with monoclonal antibodies. In vivo, peptide-HLA complexes are recognized by T cell receptors. Because these antibody drugs recognize the same exact targets as T cells they are called T cell receptor mimics (TCRm). The Pure MHC platform technology al-

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EXPANDING MANUFACTURING CAPABILITIES Cytovance Biologics, Inc. is a biopharmaceutical contract manufacturing company specializing in the production of therapeutic proteins and antibodies from mammalian and microbial systems.Â In 2013, Cytovance Biologics was recognized as one of the fastest growing companies in Oklahoma City by the Greater Oklahoma City Chamber. The company is rapidly expanding its capabilities in Microbial, Mammalian, and Fill Finish Operations with the addition of a new 1000L Microbial Fermenter, a Fill/Finish line, and a 2500L stainless bioreactor. The increase in scale and services at its existing facilities identified the need for a new building to house GMP warehousing and future manufacturing expansions. The new construction will contain 20,000 sq. ft. of climate controlled and monitored warehouse space and 10,000 sq. ft. for existing and future Manufacturing Operations. Cytovance is expected to add 25 new personnel to its workforce by the end of 2014 as it continues to expand its base in Oklahoma City. www.cytovance.com

The Oklahoma Health Center Foundation

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FOOD SAFETY COMPANY LOG10 WELCOMED TO PONCA CITY Ponca City, a free Wi-fi micropolitan in north Central Oklahoma, is proud to welcome Log10 to the community.Â Log10 specializes in food safety, consulting and manufacturing including probiotic and enzymatic additives for all types of consumables. The company, which derives its name from a logarithm commonly used in food science, recently signed a lease on Ponca Cityâ&#x20AC;&#x2122;s newest industrial building and is in the process of renovating the building into a state of the art food grade laboratory and manufacturing facility. Company principals include Ph.D.s and technicians with significant experience in their fields both in private industry and academia.Â Â The company is currently serving several national accounts by producing probiotic products and providing food safety consulting. â&#x20AC;&#x153;Ponca City is pleased to welcome Log10 to the neighborhood. It's a great day in Ponca City.â&#x20AC;? www.goponca.com

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www.oklahomahealthcenter.com 800 Research Parkway, Suite 400 Oklahoma City, OK 73104 405.271.2200

Cytovance Biologics, Inc. is a biopharmaceutical contract manufacturing company specializing in the production of therapeutic proteins and antibodies from mammalian and microbial systems. In 2013, Cytovance Biologics was recognized as one of the fastest growing companies in Oklahoma City by the Greater Oklahoma City Chamber. The company is rapidly expanding its capabilities in Microbial, Mammalian, and Fill Finish Operations with the addition of a new 1000L Microbial Fermenter, a Fill/Finish line, and a 2500L stainless bioreactor. The increase in scale and services at its existing facilities identified the need for a new building to house GMP warehousing and future manufacturing expansions. The new construction will contain 20,000 sq. ft. of climate controlled and monitored warehouse space and 10,000 sq. ft. for existing and future Manufacturing Operations. Cytovance is expected to add 25 new personnel to its workforce by the end of 2014 as it continues to expand its base in Oklahoma City. www.cytovance.com

The Oklahoma Health Center Foundation

Promoting innovations in research, healthcare and education • • •

More than $1/2 billion in new construction since 2000 Almost 8 million square feet of building space - a $3 billion capital investment Approximately 500 scientists and physician scientists are exploring ways to predict and fight cancers, eye diseases, Huntington’s disease, Alzheimer’s, to name a small sampling of the tremendous research going on every day

TEAM, EXPERTISE AND FOCUS – A UNIQUE COMBINATION

CareerTech: BIOSCIENCES AND MEDICINE ACADEMY

ARL BioPharma, Inc., a contract research laboratory, is partnering with DNA Solutions, a genetic testing laboratory, and the Kupiec Group, a knowledge-based group of experts, to offer broad services to the biotechnology community. The combination of the three companies provides focus, expertise and a team of scientific professionals to meet the unique needs of the pharmaceutical, biotechnology and patent industries including: analytical, microbiological, genetic testing and consultation services. ARL’s pharmaceutical testing expertise combined with DNA Solutions genetic testing expertise provides opportunities to pharmaceutical and biotechnology companies as well as law firms looking for high-quality services and customer service. www.arlok.com and www.dnasolutionsusa.com

Francis Tuttle Technology Center’s Biosciences and Medicine Academy is designed to prepare high school students for success in colleges and universities. It combines rigorous mathematics and science (preAP and AP level only) with medical-related classes to give students an understanding of the broad field of biosciences and medicine, along with the academics they will need to be successful in bachelor's programs. This program of study is designed to help students determine what career fields they want to pursue. High school students may attend for up to three school years. Graduates from the academy should be planning to pursue college or university degrees in bioscience and medical fields. Program completers’ education plans will be degree programs in higher education. To be successful in these careers, a student should have analytical thinking skills; an aptitude for science, writing, math, communication and problem-solving; time management skills; an interest in continual learning; self-motivation; a strong work ethic; the ability to work independently; and a high level of interpersonal skills. www.okcareertech.org

PROTECTING INTELLECTUAL PROPERTY FOOD SAFETY COMPANY LOG10 WELCOMED TO PONCA CITY Ponca City, a free Wi-fi micropolitan in north Central Oklahoma, is proud to welcome Log10 to the community. Log10 specializes in food safety, consulting and manufacturing including probiotic and enzymatic additives for all types of consumables. The company, which derives its name from a logarithm commonly used in food science, recently signed a lease on Ponca City’s newest industrial building and is in the process of renovating the building into a state of the art food grade laboratory and manufacturing facility. Company principals include Ph.D.s and technicians with significant experience in their fields both in private industry and academia. The company is currently serving several national accounts by producing probiotic products and providing food safety consulting. “Ponca City is pleased to welcome Log10 to the neighborhood. It's a great day in Ponca City.” www.goponca.com

www.oklahomahealthcenter.com 800 Research Parkway, Suite 400 Oklahoma City, OK 73104 405.271.2200

Dunlap Codding – the region’s largest and most versatile boutique IP firm – serves a global and sophisticated client base. The firm listens and responds to each client’s unique needs with micro-customized services; provide each with an exemplary work product; and help clients create and protect robust intellectual property portfolios, vigorously pursued and properly grounded in science and law. The firm assists legacy and start-up companies in the acquisition and exploitation of patent portfolios of cutting edge research in the areas of pharmaceuticals, drug formulation, medical technology, drug screening, inflammation inhibitors, regulation of skin pigmentation, testing for environmental pollution, novel treatments of septic shock, and water and food quality testing. We have an exceptional track record in identifying and protecting inventions involving biotechnology, life sciences and pharmaceuticals. Dunlap Codding gives back to its community by offering a space for collaborative work so that organizations can grow to the next stage of evolution. www. dunlapcodding.com

Increases in Oklahoma Bioscience and Medicine ACT scores 2012-2013

% ACT Score Increased

EXPANDING MANUFACTURING CAPABILITIES

29% 20% Mathematics

Science

TSET invests in cutting-edge research by Oklahoma biomedical and behavioral scientists to improve health, leverage outside research funding and increase the number of highly skilled jobs in the state.

Dedicated to Research in Oklahoma

TSET has expanded research funding in Oklahoma by dedicating $45 million to the: • Stephenson Cancer Center for the TSET Cancer Research Program and the Oklahoma Tobacco Research Center • Oklahoma Center for Adult Stem Cell Research, collaboratively governed by OMRF, OUHSC and OSU TSET’s investment in life-saving research is creating jobs and changing lives. Learn more at TSET.OK.GOV

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OKLAHOMA SUPPORT FOR BIOSTARTUPS The Oklahoma Bioscience Association and i2E have collaborated to send four up-and-coming Oklahoma bioscience companies to the 2014 Biotechnology Industry Organization convention in San Diego. “We’re happy that we can provide these scholarships to send some of Oklahoma’s most promising emerging companies to BIO,” said Scott Meacham, CEO of i2E and the Oklahoma Bioscience Association. “The BIO convention brings together potential research partners, investment sources and service providers from around the world to one location. It’s important that these Oklahoma startups can access these educational and networking opportunities.” Meet the companies that were each awarded $3,000 BIO scholarships: Cope Technology Affiliates – Provides sales of instrumentation and fee-for-service for Surface Plasmon Resonance technology used in biomolecular interaction analysis. Cope Technology Affiliates represents SensiQ Technologies, Inc., in the sale of instrumentation and complementary services. Drik, LLC – Provides toxicology testing of pharmaceuticals, chemicals, cosmetics, nanomaterials, nanotechnology compounds and drugs of abuse using in vivo and in vitro approaches that include 3D organotypic slice culture technique. EpimedX, LLC – The company was formed specifically to commercialize gene regulation therapy, a promising technology that is expected to provide a safe, cost-effective and permanent treatment for Sickle Cell Disease, beta-thalassemia and malaria without dangerous or harmful side effects. VADovations Inc. – The company’s Right Ventricular Assist Device is a platform technology for creating miniaturized, implantable hear assist pumps that are smaller, safer and cheaper than products currently in use.

OKLAHOMA BIO SELLING POINTS > High quality, affordable and available facilities > University of Oklahoma University Research Park > Incentives available for qualifying companies > Oklahoma’s bioscience sector: • Contributes more than $6.7 billion in economic activity • Supports more than 51,000 Oklahoma jobs • Has annual revenues more than $4.1 billion > Significant pockets of research excellence: • Dean McGee Eye Institute • Laureate Institute of Brain Research • Oklahoma Medical Research Foundation • Oklahoma State University • Samuel Roberts Noble Foundation • University of Oklahoma Health Sciences Center

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> Innovative service providers are growing Oklahoma bioscience: • Accele BioPharma • Emergent Technologies • i2E, Inc. • OKBIO Association • Oklahoma Center for the Advancement of Science and Technology • Oklahoma Life Science Fund > Oklahoma’s cutting-edge research strengths: • Autoimmune Diseases and Immunology • Biofuels • Cardiovascular Research • Glycobiology and Carbohydrates • Infectious Disease and Microbiology • Plant Improvement • Natural Products for Health • Value-Added Food Products • Vision Research

OKLAHOMA BIOSCIENCE FAST FACTS 1. The Oklahoma Center for the Advancement of Science and Technology (OCAST), has funded 2,461 projects at more than $249 million, attracting $5.1 billion in private sector and federal dollars for a return on investment of 21:1. 2. The University of Oklahoma Health Sciences Center is dedicated to both basic and translational research, with resources such as a Phase 1 Clinical Trials Program in the Cancer Center, a comprehensive Diabetes Center, and the only Oklahoma NIH grant to enhance collaboration between clinical and basic research missions. 3. The 27-acre, $100 million University Research Park, adjacent to the OU Health Center complex, is home to 37 science-based companies. 4. The Samuel Roberts Noble Foundation, in Ardmore, is the largest private foundation in the country conducting plant science and agriculture research. 5. A drug to treat glioblastoma multiforme, developed by scientists at the Oklahoma Medical Research Foundation, is currently in clinical trials. 6. The Dean McGee Eye Institute has had 19 uninterrupted years of coveted “Unrestricted Grant” support from Research to Prevent Blindness. 7. The Bioenergy Center at Oklahoma State University has identified regulatory and signaling genes that are important for a high tiller number in switchgrass – critical for increasing switchgrass biomass – by using gene expression profiling in inbred lines with a contrasting tiller number trait.

12. Moleculera Labs, which recently closed a $700,000 investment round, has developed a series of tests, the Cunningham Panel, which predicts a patient’s likelihood having Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococci (PANDAS). 13. In 2014, the fast-growing Cytovance Biologics, Inc. announced plans for a multi-million-dollar expansion in Oklahoma City. The projects involve expanding its manufacturing operations by 10,000 square feet and good manufacturing practice (GMP) warehousing by 20,000 square feet of climate-controlled and monitored space. 14. In little more than a year, Accele Biopharma, a bioscience business accelerator, has invested in 4 bio companies: Pamlico Biopharma is developing an antibody mixture that treats pneumonia; Jortan, is founded on the research of Dr. Jordan Tang at OMRF and is a promising diabetes technology; Synereca is creating a compound to fight drug-resistant bacterial infections; and Otologics, which is advancing a compound that protects people who are exposed to high decibels from hearing loss.

OKLAHOMA BIO ABOUT TOWN

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8. i2E, Inc. invested over $2.1 million in 6 Oklahoma bioscience companies in 2014 and $10 million over the past 15 years. 9. VADovations, who has developed the world’s smallest implantable blood pump, won a $3 million NIH Fast-Track SBIR award in 2012 and recently received the Phase I portion of a second Fast-Track for up to $6.75 million. 10. Caisson Biotech LLC, a biopharmaceutical company with a patented heparosan-based drug delivery technology, HEPtuneTM, announced that it has expanded the scope of its partnership with global healthcare leader Novo Nordisk A/S (NYSE:NVO). 11. In 2012, Selexys Pharmaceuticals completed a $23 million Series A Equity Financing Round led by MDM Capital and entered into an acquisition agreement with Novartis Pharmaceuticals with a potential value of $665 million. 12. Moleculera Labs, which recently closed a $700,000 investment round, has developed a series of tests, the Cunningham Panel, which predicts a patient’s likelihood having Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococci (PANDAS). 13. In 2014, the fast-growing Cytovance Biologics, Inc. announced plans for a multi-million-dollar expansion in Oklahoma City. The projects involve expanding its manufacturing operations by 10,000 square feet and good manufacturing practice (GMP) warehousing by 20,000 square feet of climate-controlled and monitored space. 14. In little more than a year, Accele Biopharma, a bioscience business accelerator, has invested in 4 bio companies: Pamlico Biopharma is developing an antibody mixture that treats pneumonia; Jortan, is founded on the research of Dr. Jordan Tang at OMRF and is a promising diabetes technology; Synereca is creating a compound to fight drug-resistant bacterial infections; and Otologics, which is advancing a compound that protects people who are exposed to high decibels from hearing loss.

6. The Dean McGee Eye Institute has had 19 uninterrupted years of coveted “Unrestricted Grant” support from Research to Prevent Blindness. 7. The Bioenergy Center at Oklahoma State University has identified regulatory and signaling genes that are important for a high tiller number in switchgrass – critical for increasing switchgrass biomass – by using gene expression profiling in inbred lines with a contrasting tiller number trait. Spring 2014 i&E

2014 OKBio Directory Agriculture & Environmental Related Bio Polymer Polym Po lym ymer y e Ind Indust Industries usttrie es Tulsa T Tul sa sa www.biopolymerindustries.com www.bi www biiopo opolym lymeri lym r ndu d str stt ies es.co es om BioPolymer Industries B Bio P yme Pol ymer Indu ndustr ndu s ies ie services s rvi se v ces es the th he needs need need eeds off the of various var va a iou ous ssegments ou egm g ent e so the erosion ero ro osio sion n control ccont ontrol ont rol utilize market mar ket th that a can at a ut utili iliize z water water e soluble solubl so sol ublee polymer ubl poly poly olymer mer me technology. techno tec hnolog hno logy. log y Bio-Cide International, Bio io o-Ci C de e Int n ern nt er ati a ona onal, l, Inc. In . Inc Norman Nor o man m www.bio-cide.com www ww.bi ww .bio-c .bi o- ide ide.co com co m Bio-Cide International, Bio-Ci Bio -Cide -Ci de Int Intern ernati ern ationa ati onal,l,l Inc. ona Inc nc.. is is the the leading leadin lea dingg din manufacturer Stabilized manufa man ufactu ufa cturer ctu rer of St Stabi abiliz abi lized liz ed Chlorine Chlori Chl orine ori ne Dioxide Dioxid Dio xidee xid Acidified Sodium and Ac Acidi idi difie fied fie d Sodi S odium odi um Chlorite Chlori Chl orite ori te sanitizers saniti san itizer iti zerss and zer and disinfectants. disinf dis infect inf ectant ect ant nts. s s. BugRight BugRig Bug Ri ht Rig Bristow Bristo Br Bri stow sto w www.bugright.com www.bu www .bugri bugri g ght ght.co .com .co m bugRIG bug RIGHT RIG HT is the or organ ganic gan ic non-toxic non-to non -toxic -to xic pest pest bugRIGHT organic repellent repell rep ellent ell ent that that is safe safe for for people, people peo ple,, animals, ple anim anim imalss, and and n environment. the he en envir vironm vir onment onm ent. ent Kelco CP Kel Ke co o Okmulgee Okmulg Okm ulgeee ulg www.cpkelco.com www.cp www .cpkel .cp kelco. kel co.com co. com CP Kelco Ke co is a leading Kel lead lead ea ing ng producer produ pr oducer odu cee of specialty speci sp e altty hydrocolloids hydroc hyd rocoll roc olloid oll oidss with oid w keyy product prod prod roduct uct lines uc lilnes nee such su uch Cellulose Gum,, as Gellan Gel ellan el n Gum, Gu um, Pectin, Pec e tin n, C ellulo u se s Gum G Xanthan Carboxymethyl Xantha Xa Xan h n Gum, Gum, um Carrageenan, C rra Ca r gee g nan n , Carb a oxymet m hyl Cellulose Cellul Ce Cel ulose ul ose and an nd Microparticulated M ropa Micr oparticul c ate a d Whey Whey Protein Concentrate, well Protei Pro tein tei n Conc C cent en rat rate, as a wel w e l as other othe h r unique biopolymers. biopol bio po yme m rs. s Crystal C Cry stall Laboratory, sta Labo Labo aborattory ory, Inc. n LLuther Lut h her www.crystallabsllc.com www.cr www rysttallabs a llc l .co c m Crystal C Cry s l Laboratory sta Labo ab b rat a ory r has haas been n supplying pollens powdered allergens an powde and wdered wde red aller l gen le g s to to customers in and United ou of th out tthee Uni U nited ni ed States S atess for over 25 years. Sta Crystal Laboratory Cry Labo b ratory carries thousands of different raw w allergenic alllergen genic products gen p ducts in inventory, including pro pollens, pol o len ns, molds, mo ds, foods mol o and epidermals. Environmental Env n iro r nme n ntal Testing, Inc. Oklahoma O Okl ahoma City www.eti-lab.com www.et ti-lab.com Environmental E En Env ironmental Testing, Inc. (ETI) is a full service petroleum testing laboratory which adheres to ASTM methods and delivers analysis for a wide range of petroleum products. Fort Environmental Laboratories, Inc. Stillwater www.fortlabs.com Fort Environmental Laboratories is an environmental toxicology laboratory and consulting firm specializing in study of amphibians, reptiles, and fish. Grazinglands d Research Laboratory El Reno www.ars.usda.gov w www .arrs.u usdaa.go ov mission Grazinglands T missi The s on o of o the h Gr G azi z ngl g and n s Research Rese s arc r h develop deliver LLaboratory Lab o tor ora t y iiss tto od eveelop p and an nd d eliver v improved impro p ved management ttechnologies, te tec h log hno logies ies, mana ies a gem gement ntt strategies, sttrat r egi eg es, e and a d an planning sstrategic str ate tegic i an and d tact ttactical actica call plan ca p annin an ningg ttools. nin ools. oo ool s.

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Helena Chemical C emi Ch e cal c Company Compa Co mpany mpa ny Helena Coweta Coweta www.helenachemical.com www.he www .helen .he lenach enach achemi emical emi cal.co ca .com .co m Helena’s Helena Hel ena’s ena ’s core core strength strengt stre ngth ngt h is is our our commitment commit com mitmen mit mentt men to provide provid pro videe customers vid cust cust ustome omers ome rs with with efficient effi effi fficie cien cie nt delivery d ive del iv ry of products produc pro ducts duc ts and services servi servi rv ces es that thatt help help increase in eas incr ea e productivity, pro produc roduc ductiv tivity tiv ity,, enhance ity enha enha nhance ce crop crop yields, yields yie lds,, and lds and provide p vid pro videe reliable rel e iab able le product produc pro ductt performance. duc perf perf erform ormanc orm ance. anc e.

RTASCo RTASCo Oklahoma Oklaho Okl ahoma aho m City ma City www.te www .tepco .te pcopro pco produc pro ducts. duc ts.com ts. com www.tepcoproducts.com RTASCo uses uses patented patent pat ented ent ed technologies tec ecchno no olog ogies og ess that that a offer o err off RTASCo econom eco nomica nom cal solutions ca solu olutio t ns n to remediate rem e edi e ate a and a d clean-up an clea e n-up p economical wi -va wide - rie r tyy off fuel fueel spills, spil p ls, s oil spills, spil p ls, and an nd other otheer a wide-variety organi org an c hydrocarbon hydr y oca o rbo r n spills spil p lss from fro om hard r surfaces, su urfaacess, organic so ls, and soi a d water. an w te wate t r. soils,

Johnson Johnso Joh nson nso n Agronomics, Agro Agro gronom nomics nom ics, Inc. ics Inc. ncc Weatherford Weathe Wea therfo the rford rfo rd d www.johnsonargonomicsinc.com www.jo www .johns .jo hnsona hns onargo ona rgonom rgo omics om c inc n .co nc com co m Johnso Joh s n Agronomics’ Agro Agro gronom nomics nom ics’ goal ics o iss to o help heelp farmers f mer far merss Johnson produce pro roduc ro ducee economical duc econ o omi om cal ca and a d environmentally an envi envi v ron o men m tal t lyy sound sou o nd d crops. cro rops. ro ps Johnson Johns Jo hnson hns n Agronomics Ag ono Agr n mic micss engages enga g ges g in soil s ili so analysis, an lys ana lysis, is, s, irrigation irrig i ati ation at on scheduling, schedu sch ed lin ling, study st dy off insects, stu ins nsect ec s, entomology plant pathology. entomo ent omolog omo ogyy study, og stud stud tudy,, and pl p ant pa patho h log ho ogy.

> me memb e mbb er

Nu N Era a Farms Fa m Stillwater S llw St Sti lwate lw t r www.nuerafarms.com www.nu www n era r far fa ms.com Established Es abl Est ab ish shed sh e in 1982, Nu-Era Farms Research facility fac t functions fu ctions as a contract facility for fun industrial ind dustrial organizations that are testing parasiticides for use on domestic livestock and companion animals and their housing facilities. Oklahoma Crop Improvement Association Stillwater www.okcrop.com OCIA is designated by Oklahoma State University as the seed certifying agency for the State of Oklahoma in accordance with the Oklahoma Seed Laws. Oklahoma Genetics, Inc. Stillwater www.okgenetics.com Oklahoma Genetics, Inc. is a nonprofit 501(c) (5) corporation that assembles in an organized manner as a group of interested and capable seed enterprises to promote stewardship and publicize and market the use of improved genetics, traits, and benefits of quality Pedigreed seed and vegetatively propagated materials. Orbitek, Inc Tulsa www.orbitekinc.com Orbitek offers multiple feedstock flexibility. Orbitek’s Three- Phase Biodiesel Production Solution is capable of taking even the most degraded feedstock and converting it into ASTM quality biodiesel fuel. Poole Chemical Altus www.poolechemical.com Poole Chemical Company was established to sell various liquid and dry fertilizer products, and will help you choose and use the right combination of agricultural products to improve im mprovee yeilds and profit quickly. qui u ckly. QuanTEM Qua uanTE n M Laboratories, nTE Labo Labo aborat ra ori rat o es, s LLC LL LC Oklahoma O aho Okl a ma City Citty www.quantem.com www.qu www .q ant .qu n em. m com QuanTem QuanTe Qua Tem is a nationally Te naational n ly l accredited acc c red e ite ted te environmental e iro env i nme n ntaal laboratory labo a rat r ory o specializing s eci sp ecc aliizin ng in n the the h analyses analys ana lyses lys e of o asbestos, asbest asb s os, s bacteria, bacteeria ba ria,, lead l ad a and a d mold. an mold mold old..

Sam Samuel a uel Roberts Noble Foundation Ardmor m e Ardmore www.noble.org www w .noble.org The Noble Foundation is an independent, nonprofit institute conducting plant science research and agricultural programs to enhance agricultural productivity. Founded in 1945 by Lloyd Noble, the Noble Foundation’s early efforts focused on educating and encouraging area farmers and ranchers to practice land stewardship and resource conservation. Set Environmental Noble www.setenv.com Setenv is an evironmental services company that provides environmentally friendly spill clean up. Setenv serves a variety of industries including chemical, pharmaceutical, disposal factories, and universities. Surbec Environmental, LLC Norman www.surbec.com Surbec Environmental, L.L.C. is a company of engineers and scientists developing and designing Surfactant for Groundwater Remediation. Tallgrass Environmental Solutions Luther www.tallgrasssolutions.com Tallgrass Solutions provides services in the following areas: erosion control, custom seeding and hydromulching, wetlands and riparian plantings, and vegetarian management. VF Canna, LLC Stillwater www.vfcanna.com VF Canna is hoping to revitalize the canna lily industry by offering guaranteed virus-free canna lilies on the market. The canna lily virus has infected nearly all of the canna lily crops in many countries including the U.S., but VF Canna is using the latest scientific advancements to ensure that our canna are virus-free.

Bio Informatics Avansic Tulsa www.avansic.com www Avansic Ava v nsic o offers ffeers a wide range n of digital d gital forensics di forens e ics i services corporate servic ces for corpo r rate and n litigation litigaation purposes. purp posees. Associates, Vieux & Asso Vieux A s cia sso ates tes, Inc. nc Norman Nor a www.vieuxinc.com www w .vi v eux uxinc ux nc.co om Vieux, V Vie u In ux, IInc. c is an c. a engineering engineeering eng n technology ng t hno tec hnolog logyy firm log firm r specializing water information specia spe c liz cia l ing n in n wa w ter er in nfor f mat mation n software, so oftw ftware a , products services. produc pro ducts and se duc ervi rv ces ce .

2014 OKBio Directory Agriculture & Environmental Related Bio Polymer Industries Tulsa www.biopolymerindustries.com BioPolymer Industries services the needs of various segments of the erosion control market that can utilize water soluble polymer technology. Bio-Cide International, Inc. Norman www.bio-cide.com Bio-Cide International, Inc. is the leading manufacturer of Stabilized Chlorine Dioxide and Acidified Sodium Chlorite sanitizers and disinfectants. BugRight Bristow www.bugright.com bugRIGHT is the organic non-toxic pest repellent that is safe for people, animals, and the environment. CP Kelco Okmulgee www.cpkelco.com CP Kelco is a leading producer of specialty hydrocolloids with key product lines such as Gellan Gum, Pectin, Cellulose Gum, Xanthan Gum, Carrageenan, Carboxymethyl Cellulose and Microparticulated Whey Protein Concentrate, as well as other unique biopolymers. Crystal Laboratory, Inc. Luther www.crystallabsllc.com Crystal Laboratory has been supplying pollens and powdered allergens to customers in and out of the United States for over 25 years. Crystal Laboratory carries thousands of different raw allergenic products in inventory, including pollens, molds, foods and epidermals. Environmental Testing, Inc. Oklahoma City www.eti-lab.com Environmental Testing, Inc. (ETI) is a full service petroleum testing laboratory which adheres to ASTM methods and delivers analysis for a wide range of petroleum products. Fort Environmental Laboratories, Inc. Stillwater www.fortlabs.com Fort Environmental Laboratories is an environmental toxicology laboratory and consulting firm specializing in study of amphibians, reptiles, and fish. Grazinglands Research Laboratory El Reno www.ars.usda.gov The mission of the Grazinglands Research Laboratory is to develop and deliver improved technologies, management strategies, and strategic and tactical planning tools.

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Helena Chemical Company Coweta www.helenachemical.com Helena’s core strength is our commitment to provide customers with efficient delivery of products and services that help increase productivity, enhance crop yields, and provide reliable product performance.

RTASCo Oklahoma City www.tepcoproducts.com RTASCo uses patented technologies that offer economical solutions to remediate and clean-up a wide-variety of fuel spills, oil spills, and other organic hydrocarbon spills from hard surfaces, soils, and water.

Johnson Agronomics, Inc. Weatherford www.johnsonargonomicsinc.com Johnson Agronomics’ goal is to help farmers produce economical and environmentally sound crops. Johnson Agronomics engages in soil analysis, irrigation scheduling, study of insects, entomology study, and plant pathology.

> memb er

Nu Era Farms Stillwater www.nuerafarms.com Established in 1982, Nu-Era Farms Research facility functions as a contract facility for industrial organizations that are testing parasiticides for use on domestic livestock and companion animals and their housing facilities. Oklahoma Crop Improvement Association Stillwater www.okcrop.com OCIA is designated by Oklahoma State University as the seed certifying agency for the State of Oklahoma in accordance with the Oklahoma Seed Laws. Oklahoma Genetics, Inc. Stillwater www.okgenetics.com Oklahoma Genetics, Inc. is a nonprofit 501(c) (5) corporation that assembles in an organized manner as a group of interested and capable seed enterprises to promote stewardship and publicize and market the use of improved genetics, traits, and benefits of quality Pedigreed seed and vegetatively propagated materials. Orbitek, Inc Tulsa www.orbitekinc.com Orbitek offers multiple feedstock flexibility. Orbitek’s Three- Phase Biodiesel Production Solution is capable of taking even the most degraded feedstock and converting it into ASTM quality biodiesel fuel. Poole Chemical Altus www.poolechemical.com Poole Chemical Company was established to sell various liquid and dry fertilizer products, and will help you choose and use the right combination of agricultural products to improve yeilds and profit quickly. QuanTEM Laboratories, LLC Oklahoma City www.quantem.com QuanTem is a nationally accredited environmental laboratory specializing in the analyses of asbestos, bacteria, lead and mold.

Samuel Roberts Noble Foundation Ardmore www.noble.org The Noble Foundation is an independent, nonprofit institute conducting plant science research and agricultural programs to enhance agricultural productivity. Founded in 1945 by Lloyd Noble, the Noble Foundation’s early efforts focused on educating and encouraging area farmers and ranchers to practice land stewardship and resource conservation. Set Environmental Noble www.setenv.com Setenv is an evironmental services company that provides environmentally friendly spill clean up. Setenv serves a variety of industries including chemical, pharmaceutical, disposal factories, and universities. Surbec Environmental, LLC Norman www.surbec.com Surbec Environmental, L.L.C. is a company of engineers and scientists developing and designing Surfactant for Groundwater Remediation. Tallgrass Environmental Solutions Luther www.tallgrasssolutions.com Tallgrass Solutions provides services in the following areas: erosion control, custom seeding and hydromulching, wetlands and riparian plantings, and vegetarian management. VF Canna, LLC Stillwater www.vfcanna.com VF Canna is hoping to revitalize the canna lily industry by offering guaranteed virus-free canna lilies on the market. The canna lily virus has infected nearly all of the canna lily crops in many countries including the U.S., but VF Canna is using the latest scientific advancements to ensure that our canna are virus-free.

Bio Informatics Avansic Tulsa www.avansic.com Avansic offers a wide range of digital forensics services for corporate and litigation purposes. Vieux & Associates, Inc. Norman www.vieuxinc.com Vieux, Inc. is an engineering technology firm specializing in water information software, products and services.

Best Energy Solutions, LLC Tulsa www.best-ok.com Best Energy Solutions, LLC was established to develop methods for the production and utilization of algae. High Plains Bioenergy Guymon www.highplainsbioenergy.com High Plains Bioenergy’s first endeavor is a 30 million-gallon-per-year biodiesel plant that uses animal fats, including pork fat from the Seaboard Foods’ Guymon processing plant, and vegetable oils as the feedstock for biodiesel. Ko-Ko Best, Inc. Tulsa www.kbi-ok.com KoKo-Best, Inc. was established to capitalize on a proven technology to produce ethanol and protein from cereal grains. Oklahoma Bioenergy Center Oklahoma City www.okbioenergycenter.org The Oklahoma Bioenergy Center is a collaboration among the University of Oklahoma, Oklahoma State University, and the Samuel Roberts Noble Foundation to cultivate the growth of Oklahoma’s renewable energy industry. Sol Tactics Norman www.soltactics.com Reshaping the face of energy conservation, Soltactics was founded to provide solutions for industry on energy costs with the greatest energy savings for the customer.

Bioenergy & Related Syntroleum Corporation Tulsa www.syntroleum.com Syntroleum Corporation’s synthetic fuel technologies make it a recognized force in the renewable fuels, biomass-to-liquids (BTL), gas-to-liquids (GTL), and coal-to-liquids (CTL) industries. Totally Green, Inc. Tulsa www.totallygreen.com Totally Green seeks to be a catalyst for change in the food and beverage industry by providing compostable packaging alternatives and organic food processing systems along with green education and advocacy.

Biotech, Pharmaceutical & Related Accele BioPharma Oklahoma City www.accelebio.com Accele BioPharma is an incubator for early stage life science technologies that have the potential to dramatically improve human healthcare, have strong commercial promise and have the potential for generating early proof of concept data.

Advance Research Chemicals Catoosa www.fluoridearc.com Advance Research Chemicals, Inc. offers basic and advanced chemical applications and services in a wide array of industries including military defense, semiconductors, battery materials, pharmaceuticals, medical devices, automotive components, textiles, agricultural solutions, surfactants and industrial cleaners.

> m em ber Altheus Therapeutics, Inc. Oklahoma City www.altheustherapeutics.com Altheus Therapeutics, Inc. is developing Zoenasa Oral Tablets and Rectal Gel formulations as novel front-line therapies for the treatment of ulcerative colitis and other inflammatory bowel diseases. Analytical Edge Laboratories Oklahoma City www.theedgelabs.com Analytical testing laboratory that provides innovative methodologies for greater flexibility and higher throughput for data collection needs. Anastasia Marie Laboratories, Inc. Oklahoma City www.amlabs.com Anastasia Marie Labs, Inc. specializes in overthe-counter diabetic skin treatment products.

Charlesson, LLC Oklahoma City www.charlessonllc.com Charlesson is an ocular pharmaceutical company that is developing therapeutics for various eye diseases, including wet and dry Agerelated Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Uveitis. Choncept, LLC Oklahoma City www.choncept.com Choncept’s scientific innovation is focused on development of new technology to produce chondroitin from fermentation of recombinant bacteria to replace the current chondroitin source of beef and other animal by-products. Coare Biotechnology Oklahoma City www.coarebiotechnology.com COARE Biotechnology is a research driven pharmaceutical company dedicated to developing novel therapeutic agents designed to treat solid tumor cancers. Cosmetic Specialty Labs, Inc. Lawton www.aloe-vera.com Cosmetic Specialty Labs is skilled in developing high end, prestige skin care products, as well as custom formulated over the counter drugs.

Astellas Pharma Technologies, Inc. Norman www.astellas.com Astellas is an international pharmaceutical company intensely focused on five key therapeutic areas: cardiology, dermatology, immunology, infectious disease, and urology.

Cytovance Biologics, LLC Oklahoma City www.cytovance.com Cytovance® Biologics adds value to biopharmaceutical development programs assisting companies to advance recombinant protein, antibody and cellbased therapeutic products rapidly and cost-effectively from the laboratory bench, through clinical development and to commercial launch.

AstraZeneca www.astrazeneca.com AstraZeneca is a global innovation-driven biopharmaceutical company specialising in the discovery, development, manufacturing and marketing of prescription medicines that make a meaningful difference in healthcare. member

DermaMedics Oklahoma City www.dermamedics.com DermaMedics is a skin care company that specializies in the discovery of technologies for the dermatology market.

> m em ber Biolytx Pharmaceuticals Corporation Oklahoma City www.biolytxcorp.com Biolytx Pharmaceuticals develops a novel antibiotic peptide for use in treatment of serious hospital-acquired infections, including those resistant to current antibiotics. Caisson Biotech Oklahoma City www.caissonbiotech.com Cassion Biotech has developed a bio-superior drug delivery system, HEPylation ® System, which uses a patented composition designed to improve the performance of many powerful drug compounds in terms of safety, tolerability, efficacy, and quality.

DormaTarg, Inc. Oklahoma City www.dormatarg.com DormaTarg, Inc is a biotechnology company researching and developing therapeutic drugs for cancer recurrence prevention. Ecolab, Inc. Oklahoma City www.ecolab.com Ecolab Inc. (Ecolab) develops and markets products and services for the hospitality, foodservice, healthcare and industrial markets.

> member EpimedX Oklahoma City www.epimedx.com EpimedX, LLC is a biotechnology company that was founded in 2011 with the mission to develop Gene Regulation Therapy© – a promising technology that is expected to provide a safe, cost-effective, and permanent treatment for sickle cell disease, beta-thalassemia, and malaria without dangerous or harmful side effects. Spring 2014 i&E

Biotech, Pharmaceutical & Related contunued

Heparinex, LLC Oklahoma City www.heparinex.com Heparinex is a biotechnology company focused on the development of novel recombinant synthesis of heparinoid compounds for various markets including anticoagulation, biomaterials, and cellular modulation applications. Hyalose, LLC Oklahoma City www.hyalose.com Hyalose specializes in Hyaluronic Acid production and application. The Emergent Technologies Inc. “Sugar Companies” offer innovative technologies for producing Hyaluronic Acid, heparosan, and chondroitin in a reproducible and safe manner for a variety of medical and aesthetic uses. Hyalose was formed to commercialize unique recombinant technologies for producing Hyaluronic Acid. Integrated Physician Solutions Research Company Oklahoma City www.ipsresearch.com IPS Research Company provides phase 1-4 inpatient and outpatient clinical trials. IPS Research specializes in clinical drug trials dealing with psychiatric disorders, including Depression, Schizophrenia, Bipolar Depression, ADHD, GAD, PTSD, Dementia, Alzheimer’s Disease, Child Depression and a variety of Anxiety Disorders. Kemmx Corporation Sapulpa www.kemmx.com Kemmx Corporation is a start-up, Biotechnology company pioneering the development and commercialization of targeted analgesics for chronic pain. Their topical analgesic formulations provide long lasting pain relief with minimal side effects. Kupiec Group Oklahoma City www.arlok.com Kupiec Group is a consortium of scientific professionals specializing in pharmaceutical, genetic and forensic fields that provide knowledge-based expert services to the legal and risk management communities. Leviathan Applied Sciences Edmond Leviathan proposes a next-generation tool that will make it possible to distinguish and examine heterogeneous states among suspension cells in situ, with the potential for a significant increase in sensitivity, selectivity, resolution, and scalability over current technology. Lupus Family Registry and Repository Oklahoma City www.lupus.omrf.org The Lupus Multiplex Registry and Repository is finding the genes that cause lupus. It works with families with one or more living lupus patients from across the US, Canada, Puerto Rico and the Virgin Islands, utilizing the genetic link between blood relatives to locate responsible genes.

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Mills Biopharmaceuticals, Inc Oklahoma City A subsidiary of Core Oncology, Mills Biopharmaceuticals, LLC (Mills) manufactures ProstaSeed® Iodine 125 brachytherapy seeds for the treatment of prostate cancer. Mills’ stateof-the-art 25,000 square foot manufacturing facility features highly automated machines and advanced manufacturing systems.

> m e m be r Moleculera Labs Oklahoma City www.moleculera.com Moleculera Labs provides personalized clinical testing services for individuals suspected of suffering from PANDAS/PANS, which are treatable neurologic conditions that may be associated with motor tics, obsessive compulsive disorders (OCD) and sometimes Autism Spectrum Disorders. Otologic Pharmaceutics, Inc. Oklahoma City www.otologicpharmaceutics.com Otologic Pharmaceutics, Inc. is an organization formed specifically to commercialize promising technologies that address novel pharmacological solutions for hearing and balance health.

Synereca Pharmaceuticals Oklahoma City www.synereca.com Synereca Pharmaceuticals addresses the growing problem of bacterial resistance to current antibiotics by developing orally active drugs that restore or increase the effectiveness of existing antibiotics. Wavetech, LLC Stillwater www.wavetechllc.,com Wavetech, LLC is privately held specializing in research and development in emerging technology markets. Their emphasis is on electromagnetic technologies, including terahertz, artificial materials, and nondestructive evaluation.

Diagnostic & Related

Pamlico Biopharma Oklahoma City Pamlico Biopharma has developed personalized, targeted human antibody therapeutics against severe pneumonia that were created using patent-pending methodology from the Oklahoma Medical Research Foundation.

Accurate Environmental Oklahoma City www.accuratelabs.com Accurate Labs and Training Center provides analytical support for projects involving wastewater, drinking water, ground water, soil, sediment and sludge.

Plymouth Pharmaceuticals, Inc. Tulsa www.plymouthpharmaceuticals.com Plymouth Pharmaceuticals, Inc. is a leading research and development company exploring safe, effective, oral therapies for inflammatory skin disorders. Plymouth offers Rx and OTC products for psoriasis, eczema, acne and seborrhea dermatitis.

> memb er Allergy Laboratories, Inc. Oklahoma City www.allergylabs.com Allergy Laboratories, Inc. is a FDA licensed pharmaceutical manufacturer of over 500 different biological extracts for the diagnostic testing and therapeutic treatment of allergy.

> memb er Pure Protein, LLC Oklahoma City www.pureproteinllc.com Pure Protein focuses on HLA related immunology tools for vaccine development and immunotherapy validation. Respiron Stillwater Respiron is developing an antiviral drug, RN-1, to treat any existing and emerging strains of influenza virus. It can potentially cure flu symptoms in nearly 300 million people worldwide regardless of virus mutation.

Analytical Research Laboratories, Inc. Oklahoma City www.arlok.com ARL offers a full range of professional laboratory services including; potency, sterility, endotoxin, compendial testing, as well as consulting services, research and development and forensic legal support. Diagnostic Lab of Oklahoma Tulsa www.dlolab.com Diagnostic Lab of Oklahoma (DLO) mission is to be Oklahoma’s undisputed leader in diagnostic testing, information and services.

> m e m be r Selexys Pharmaceuticals Corporation Oklahoma City www.selexys.com Selexys is a development stage biopharmaceutical company focused on the treatment of inflammatory and thrombotic diseases. The company has developed antibodies that block recruitment of white blood cells to activated endothelium and platelets.

DNA Solutions, Inc. Oklahoma City www.dnasolutionsusa.com DNA Solutions, Inc. provides highly discerning service products including paternity and forensic testing in humans and sire confirmation, genotype registry, DNA banking and forensic identification in animals.

Biotech, Pharmaceutical & Related contunued Heparinex, LLC Oklahoma City www.heparinex.com Heparinex is a biotechnology company focused on the development of novel recombinant synthesis of heparinoid compounds for various markets including anticoagulation, biomaterials, and cellular modulation applications. Hyalose, LLC Oklahoma City www.hyalose.com Hyalose specializes in Hyaluronic Acid production and application. The Emergent Technologies Inc. “Sugar Companies” offer innovative technologies for producing Hyaluronic Acid, heparosan, and chondroitin in a reproducible and safe manner for a variety of medical and aesthetic uses. Hyalose was formed to commercialize unique recombinant technologies for producing Hyaluronic Acid. Integrated Physician Solutions Research Company Oklahoma City www.ipsresearch.com IPS Research Company provides phase 1-4 inpatient and outpatient clinical trials. IPS Research specializes in clinical drug trials dealing with psychiatric disorders, including Depression, Schizophrenia, Bipolar Depression, ADHD, GAD, PTSD, Dementia, Alzheimer’s Disease, Child Depression and a variety of Anxiety Disorders. Kemmx Corporation Sapulpa www.kemmx.com Kemmx Corporation is a start-up, Biotechnology company pioneering the development and commercialization of targeted analgesics for chronic pain. Their topical analgesic formulations provide long lasting pain relief with minimal side effects. Kupiec Group Oklahoma City www.arlok.com Kupiec Group is a consortium of scientific professionals specializing in pharmaceutical, genetic and forensic fields that provide knowledge-based expert services to the legal and risk management communities. Leviathan Applied Sciences Edmond Leviathan proposes a next-generation tool that will make it possible to distinguish and examine heterogeneous states among suspension cells in situ, with the potential for a significant increase in sensitivity, selectivity, resolution, and scalability over current technology. Lupus Family Registry and Repository Oklahoma City www.lupus.omrf.org The Lupus Multiplex Registry and Repository is finding the genes that cause lupus. It works with families with one or more living lupus patients from across the US, Canada, Puerto Rico and the Virgin Islands, utilizing the genetic link between blood relatives to locate responsible genes.

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Sensulin, LLC Oklahoma CIty www.sensulin.com Sensuli, LLC is developing a true once-a-day glucose-responsive insulin that may mimic a healthy human pancreas. Sensulin™ may eliminate the need for basal & prandial insulin, offer a substantial improvement in the standard of care, and most importantly, give those with diabetes a chance at a normal life. Synereca Pharmaceuticals Oklahoma City www.synereca.com Synereca Pharmaceuticals addresses the growing problem of bacterial resistance to current antibiotics by developing orally active drugs that restore or increase the effectiveness of existing antibiotics. Wavetech, LLC Stillwater www.wavetechllc.,com Wavetech, LLC is privately held specializing in research and development in emerging technology markets. Their emphasis is on electromagnetic technologies, including terahertz, artificial materials, and nondestructive evaluation.

Diagnostic & Related

> memb er

Pure Protein, LLC Oklahoma City www.pureproteinllc.com Pure Protein focuses on HLA related immunology tools for vaccine development and immunotherapy validation. Respiron Stillwater Respiron is developing an antiviral drug, RN-1, to treat any existing and emerging strains of influenza virus. It can potentially cure flu symptoms in nearly 300 million people worldwide regardless of virus mutation.

Allergy Laboratories, Inc. Oklahoma City www.allergylabs.com Allergy Laboratories, Inc. is a FDA licensed pharmaceutical manufacturer of over 500 different biological extracts for the diagnostic testing and therapeutic treatment of allergy.

> memb er Analytical Research Laboratories, Inc. Oklahoma City www.arlok.com ARL offers a full range of professional laboratory services including; potency, sterility, endotoxin, compendial testing, as well as consulting services, research and development and forensic legal support. Diagnostic Lab of Oklahoma Tulsa www.dlolab.com Diagnostic Lab of Oklahoma (DLO) mission is to be Oklahoma’s undisputed leader in diagnostic testing, information and services. DNA Solutions, Inc. Oklahoma City www.dnasolutionsusa.com DNA Solutions, Inc. provides highly discerning service products including paternity and forensic testing in humans and sire confirmation, genotype registry, DNA banking and forensic identification in animals.

> m em ber Emerson Resources, Inc. www.emersonresources.com Emerson Resources provides pre-formulation through phase III and small commercial production. They have been producing phase I and II clinical supplies since 2005 and will be adding phase III and small volume and orphan drug commercial manufacturing in 2013. Enerlabs Oklahoma City www.enerlabsinc.com Enerlabs is an oil and gas company specializing in diagnostics for the oil and gas industry. Enerlabs recently purchased its first strategic laboratory, Zalco Laboratories. Glomics, Inc. Norman www.glomics.com Glomics, Inc. targets global genomics technologies, develops microarray-based technologies and provides their associated services to customers working in a variety of fields involved in microbial functional genomics, community genomics, microbial ecology, environmental microbiology, and geobiochemistry. Haus Bioceuticals, Inc. Oklahoma City www.hausbio.com Haus Bioceuticals is developing safe and effective products, including Metaderm. Metaderm resolves eczema through a vast combination of spagyric essenses formulated specifically to address the immune signaling disregulation associated with atopic dermatitis and eczema. Helix BioScience Tulsa www.helixbioscience.com Helix Bioscience is a healthcare firm focusing on innovative genetic diagnostics to help physicians effectively and accurately prescribe medications that promote better health outcomes. Inoveon Corporation Oklahoma City www.inoveon.com Inoveon is a premier medical services company that delivers solutions to detect, stage and monitor diseases affecting the eye - diabetic retinopathy, macular degeneration, and glaucoma. Inoveon’s initial target is to help patients and their providers improve diabetic retinopathy care through Inoveon diagnostic service centers that are co-located in high volume diabetes care sites. Intergenetics, Inc. Oklahoma City www.intergenetics.com Intergenetics® is a personalized medicine company focused on molecular genetics to predict the risk of cancer prior to disease occurrence. JKAutoimmunity Oklahoma City www.omrf.ouhsc.edu JKAutoimmunity provides a DNA pooling service.

LabCorp/Dianon Systems Oklahoma City www.labcorp.com LabCorp’s mission is to improve American healthcare by providing the highest quality cancer and genomic diagnostic services and personalized health information to physicians, patients, and health plans throughout the country. Oklahoma Allergy & Asthma Clinic Oklahoma City www.oklahomaallergy.com Since 1925, the Oklahoma Allergy & Asthma Clinic has specialized in the diagnosis and management of allergies, asthma and other allergic disorders in adults and children.

> m em ber Polyskope Labs Oklahoma City www.polyskopelabs.com PolySkope Labs is among the most sophisticated food safety laboratories in the world. They offer the highest quality, speed, and reliability in the industry–right in your backyard. Precision Histology Lab, Inc. Oklahoma City www.precisionhistologylab.com Precision Histology Lab, Inc. takes pride in more than 75 years of combined professional experience in the field of histology. Tulsa Medical Laboratory, LLC Tulsa www.tulsamedicallab.com TML performs a variety of diagnostic services, including tissue, cytology, bone marrow examinations, clinical consultations, blood bank services, peripheral blood and other body fluid smear consultations, and frozen section evaluation.

Foundations, Funders & Service Providers Accele Venture Partners Oklahoma City www.accelebio.com Accele Venture Partners is a venture group established as a funding mechanism for spinouts from Accele Biopharma, Inc. Accelerate, LLC Kansas www.vickeadams.com Accelerate, LLC is an Oklahoma-based business providing consulting services to entrepreneurs and small businesses. Consulting services include technical writing, business plan development and proposal writing. Acorn Growth Companies Oklahoma City www.acorngrowthcompanies.com Acorn Growth Companies is a private equity firm focused exclusively on aerospace and defense opportunities. Advancia Corporation Oklahoma City www.advancia.com Advancia’s professionals use cutting-edge technology to help clients maximize their longterm business viability and competitive advantage by using analytical tools to present the facts and options to our clients in clear and concise terms.

American Biomedical Group Oklahoma City www.americanbiomedicalgroup.com American Biomedical Group is a strategic partner that engineers business, information and technology solutions for organizations, all with the ultimate financial outcomes in view. AmerisourceBergen Drug Corporporation Tulsa www.amerisourcebergen.com AmerisourceBergen Drug Corporation delivers medicines purchased directly from the manufacturer to thousands of retail and institutional pharmacy customers on a just-intime basis. Applied Technology Specialists, Inc. Bixby www.cleanair-tech.net ATSI is an Engineering firm that can design and supply specialized pollution control equipment and technology.

> member Ardmore Development Authority Ardmore www.ardmoredevelopment.com Recognized as one of the nation’s top development organizations, the ADA owns four industrial parks totaling 3,500 acres and more than 40 buildings under lease encompassing more than one million square feet. The ADA has a 40 acre technology park under construction and operates a technology incubator. Arvest Bank Oklahoma City www.arvest.com Arvest Bank is a regional bank that operates in a unique, customer-focused way. Arvest delivers the convenience and technological advantages of a large super-regional bank, but with the local commitment and decision-making of a local community bank. Bank of Oklahoma Oklahoma City www.bankofoklahoma.com Bank of Oklahoma is a top 25 US-based bank with operations that include commercial and consumer banking, investment and trust services, mortgage origination and servicing, and an electronic transfer network. Bartlesville Development Corporation Bartlesville www.bdcok.com The BDC facilitates the recruitment, retention and expansion of primary industry jobs, and new destination retail businesses for the Bartlesville Area. BioSource Consulting Group Oklahoma City www.biosourceconsulting.com BioSource Consulting Group is a strategic consulting firm that assists entrepreneurs and growing organizations in all facets of translating ideas to commercial products, including start-up strategy.

Spring 2014 i&E

Foundations, Funders, and Service Providers contunued BioSpec Products Bartlesville www.biospec.com BioSpec has been providing innovative scientific equipment for more than 30 years. Century Venture Partners Oklahoma City www.centuryvp.com Century Venture Partners is a unique early-stage technology commercialization fund. Chesapeake Energy Corporation Oklahoma City www.chk.com Chesapeake is a Top 15 producer of oil and natural gas liquids and the most active driller of new wells in the U.S. Chesapeake NG Ventures Oklahoma City www.chk.com Chesapeake NG Ventures has invested over $300 million into the bioenergy industry, and has bolstered Chesapeake’s image in the Americas’ transitioning energy and transportation sectors. > member Chickasaw Nation Ada www.chickasaw.net Since the 1980s,Chickasaw Nation tribal government has focused most of its efforts on building an economically diverse base to generate funds that will support programs and services to Indian people. Children’s Hospital Foundation Oklahoma City www.childrenshospitalfoundation.net Children’s Hospital Foundation is the only nonprofit organization in Oklahoma whose sole focus is the advancement of pediatric research and education while supporting specialized clinical care for Oklahoma’s children. Cimarron Capital Partners Oklahoma City www.cimarroncapital.com Cimarron provides discretionary and nondiscretionary venture capital and private equity asset management services. City of Ponca City Ponca City www.goponca.com Whether it is the world’s premiere sensor test and evaluation center or Sustainable Alternative Green Energy, agriculture, or a combination of all, Ponca City offers a strategically located, non-urban environment which capitalizes on the best of North American innovation and connectivity. Claremore Development Authority Claremore www.claremoredevelopment.com CIEDA’s mission is to carry out economic activities, community development, and to bring jobs and prosperity to the Claremore area by marketing nationally and regionally to attract new businesses.

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Cole & Reed, P. C. Oklahoma City www.coleandreed.com Cole & Reed provides audit and assurance, tax planning and compliance, consulting, and accounting services to businesses of all sizes throughout Oklahoma and beyond, and has a reputation for providing quality, responsive service. Consolidated Networks Oklahoma City www.consolidatednetworks.com Consolidated Networks Corporation provides endto-end network engineering and IT services to its government, education and corporate clients. Crisalis, LLC Oklahoma City www.crisalisllc.com CRISALIS has developed specialized research database applications for research institutions, government agencies, and nonprofits. Crowe & Dunlevy Oklahoma City www.crowedunlevy.com Crowe & Dunlevy has been advising clients for over 100 years. Their depth of experience allows them to assemble dynamic legal teams to provide advice that is both focused and valuable to their client range from individuals to Fortune 100 companies. Devon Energy Oklahoma City www.dvn.com Devon Energy Corporation is a leading independent oil and natural gas exploration and production company. > member Drik, LLC Edmond www.atdrik.com Drik LLC helps clients to conduct quality pre-clinical toxicology studies utilizing a cost efficient approach. They help companies with all their outsourced toxicology needs. > member Dunlap Codding, P.C. Oklahoma City www.dunlapcodding.com Dunlap Codding, P.C. offers revolutionary partnering counsel helping global and domestic biotechnology clients create strategic, optimally profitable intellectual property portfolios. Edmond Economic Development Authority Edmond www.eeda.com The Edmond Economic Development Authority site is designed to provide assistance for those looking to establish, expand or relocate their business to Edmond, Oklahoma. Emergent Technologies, Inc. Oklahoma City www.etibio.com EmergentTechnologies reduces the costs and risks associated with the commercialization of early stage technology by identifying the right Industry/Corporate partners and producing welltimed strategic partnering arrangements.

Enid Regional Development Alliance Enid www.growenid.com The Enid Regional Development Alliance seeks to grow local businesses and companies in Enid by making resources available. Failsafe Hazmat Compliance Tulsa www.failsafehazmat.com Failsafe has developed hazmat software to help companies that ship hazardous materials (dangerous goods) with all US domestic and international shipping regulations. Freedom Pharmaceuticals Tulsa www.freedomrxinc.com As a boutique supplier of fine compounding chemicals, excipients, bases and capsules, Freedom prides itself on high quality products and first-class customer service. Galaxy Chemicals, LLC Claremore www.galaxychemfluoride.com Galaxy Chemicals has expertise in AHF, aqueous HF and elemental fluorine chemistry. They can produce fluorinated products from small to large scale with flexible packaging available. Geo-Microbial Technologies, Inc. Ochelata www.gmtgeochem.com GMT has more than 25 years of experience conducting successful surface geochemical exploration surveys all over the world in geologically and environmentally diverse settings, ranging from the arctic to the tropics, from desserts to jungles to grasslands. > member Greater Oklahoma City Chamber Oklahoma City www.okcchamber.com The Greater Oklahoma City Chamber promotes the Oklahoma Bioscience Industry by supporting recruitment partnerships and achieving national recognition. GreenTeam, Inc. Tulsa www.thegreenteaminc.com The GreenTeam, Inc. provides strategic environmental consulting. They help clients address sustainable design and environmental issues. Services include life cycle assessment (LCA) for environmental product declarations, carbon accounting, environmental management systems, and standards guidance. Hall Estill, Attorneys at Law Oklahoma City www.HallEstill.com Hall Estill is an Oklahoma based full service law firm which has created a practice that taps the knowledge of skilled attorneys while focusing on clients’ needs.

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> member Drik, LLC Edmond > member www.atdrik.com Greater Oklahoma City Chamber Drik LLC helps clients to conduct quality Oklahoma City pre-clinical toxicology studies utilizing a cost www.okcchamber.com efficient approach. They help companies with The Greater Oklahoma City Chamber all their outsourced toxicology needs. promotes the Oklahoma Bioscience Industry by supporting recruitment partnerships and > member achieving national recognition. Dunlap Codding, P.C. Oklahoma City www.dunlapcodding.com GreenTeam, Inc. Dunlap Codding, P.C. offers revolutionary Tulsa partnering counsel helping global and domestic www.thegreenteaminc.com biotechnology clients create strategic, optimally The GreenTeam, Inc. provides strategic profitable intellectual property portfolios. environmental consulting. They help clients address sustainable design and environmental Edmond Economic issues. Services include life cycle assessment Development Authority (LCA) for environmental product declarations, Edmond carbon accounting, environmental management www.eeda.com systems, and standards guidance. The Edmond Economic Development Authority site is designed to provide assistance for those Hall Estill, Attorneys at Law looking to establish, expand or relocate their Oklahoma City business to Edmond, Oklahoma. www.HallEstill.com Hall Estill is an Oklahoma based full service law Emergent Technologies, Inc. firm which has created a practice that taps the Oklahoma City knowledge of skilled attorneys while focusing on www.etibio.com clients’ needs. EmergentTechnologies reduces the costs and risks associated with the commercialization of early stage technology by identifying the right Industry/Corporate partners and producing welltimed strategic partnering arrangements.

> member Higginbotham www.higginbotham.net Higginbotham serves as a Single Source for insurance, risk management and financial services by providing access to commercial and personal property/casualty coverage, employee benefits, retirement plans, life insurance and executive compensation through broad market representation.

MedIntelligence, LLC Oklahoma City www.medintelligence.net MedIntelligence delivers quality work through internal team collaboration and their longstanding partnerships with leading universities, academicians, CME providers, medical associations, and other healthcare experts committed to the same mission of ensuring scientific integrity and balance.

Hillcrest Clinical Research Oklahoma City www.clinicalconnection.com The staff at Hillcrest Clinical Research is knowledgeable and experienced and is capable of providing fast study start-up and effective FDA and IRB submission and coordination.

MidFirst Bank Oklahoma City www.midfirst.com MidFirst Bank is one of the largest privately owned banks in the United States and competes effectively with larger banks in terms of products and services, but provides customers the service and flexibility of a community bank.

> member i2E, Inc. Oklahoma City www.i2E.org i2E, Inc. is a nationally recognized private not-for-profit corporation focused on growing innovative small businesses in Oklahoma. They work directly with entrepreneurs, researchers and companies to help them commercialize their technologies, launch and grow new businesses and access needed capital. Intergris Baptist Medical Center Oklahoma City www.integrisok.com INTEGRIS Health is one of the state s largest health systems with hospitals, rehabilitation centers, physician clinics, mental health facilities, independent living centers and home health agencies. Kalchem International, Inc. Lindsay www.kalcheminternational.com Kalchem International Imports a wide range of products from different locations around the world and can source anything from chemicals and capsules to equipment as well as provide you with all your pharmaceutical compounding needs. > member McAfee & Taft Oklahoma City www.mcafeetaft.com For nearly 60 years, clients have counted on McAfee & Taft’s multi-disciplinary approach to problem-solving, along with the depth and talent of its dedicated attorneys and support staff, to create comprehensive, customized legal solutions. McKesson Corporation Oklahoma City www.mckesson.com McKesson is dedicated to delivering the vital medicines, medical supplies and information technologies that enable the health care industry to provide patients better, safer care. MedEncentive Oklahoma City www.medencentive.com Through innovative incentives, Med Incintive helps employers, health insurers and governments of all types contain health care costs while engaging physicians and patients in ways that fundamentally change their behaviors and lead to better health for everyone.

Norman Economic Development Coalition Norman www.nedcok.com The Norman Economic Development Coalition is dedicated to expanding the economic base of the Norman community, enhancing the earning opportunities of area residents by retaining and expanding existing businesses and industries, as well as attracting desirable new employers.

Nova Venture Services Oklahoma City www.novaventureservices.com Nova Venture Services is a consultation and management firm for biotech startup companies. OGE Energy Corp Oklahoma City www.oge.com OGE Energy Corp. is the parent company of OG&E Electric Services, a regulated electric utility serving approximately 750,000 customers in a service territory spanning 30,000 square miles across Oklahoma and western Arkansas. Oklahoma Association of Health Care Providers Oklahoma City www. oahcp.org The Oklahoma Association of Health Care Providers’ mission is Driving Dramatic Improvement to Long Term Care. Oklahoma Bioscience Association Oklahoma City www.okbio.org The mission of the Oklahoma Bioscience Association is to promote the growth of biosciences in Oklahoma through partnership building, education and outreach, networking, policy development and publicity.

> m em ber Oklahoma Blood Institute Oklahoma City www.obi.org OBI is a state-wide not-for-profit blood center providing blood to patients in more than 110 hospitals in 58 Oklahoma counties as well as five counties in north central Texas. OBI’s mission is “to provide the safest and highest quality blood, services and health programs to the patients and communities we serve.

> member Oklahoma Business Roundtable Oklahoma City www.okbusinessroundtable.com The Oklahoma Business Roundtable serves as the state’s major economic development support organization. Oklahoma Capital Investment Board Oklahoma City www.ocib.org Oklahoma Capital Investment Board (OCIB) was created by the state of Oklahoma to help ensure that entrepreneurs have access to the intelligent seed and venture capital they need to launch and grow their companies. Oklahoma Center For Adult Stem Cell Research Oklahoma City www.ocascr.org The mission of the OCASCR is to catalyze researchers’ work in numerous ways, leverage resources obtainable from traditional funding agencies, and help attract additional talent to the state of Oklahoma. Oklahoma Center for Advancement of Science and Technology Oklahoma City www.ocast.state.ok.us OCAST was established in 1987 as the state’s agency for technology-based economic development. Their mandate is to “expand and diversify Oklahoma’s economy and provide new and higher quality jobs for Oklahomans by encouraging the development of new products, new processes and whole new industries in Oklahoma. Oklahoma Department of Career and Technology Education Stillwater www.okcareertech.org The Oklahoma CareerTech provides leadership and resources to ensure standards of excellence throughout the statewide system.

> member Oklahoma Department of Commerce Oklahoma City www.okcommerce.gov Oklahoma Department of Commerce focuses on increasing the quality and quantity of jobs in Oklahoma. Oklahoma Health Care Workforce Center Oklahoma City www.ohcwc.com The Oklahoman Health Care Workforce Center was created by legislation in 2006 to help alleviate the projected health care worker shortages, to help retain health care workers already employed or graduating from OK educational institutions, and to provide information about health careers to Oklahomans of all ages.

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Foundations, Funders, and Service Providers contunued Oklahoma Health Center Foundation Oklahoma City www.oklahomahealthcenter.com The Oklahoma Health Center Foundation promotes and supports the 300-acre Oklahoma Health Center complex that consists of 31 member organizations, including several cutting edge Biotech companies and support organizations. Oklahoma Innovation Institute Tulsa www.oklahomainnovationinstitute.com The Oklahoma Innovation Institute fosters collaborative research and development, entrepreneurship, company creation and retention, life-long learning and creative, futureoriented thinking. Oklahoma Life Science Fund Tulsa www.olsfventures.com Oklahoma Life Science Fund, LLC (OLSF) invests in the most promising very early-stage life science companies that are not yet able to attract venture capital. OLSF investments are made to fund validation of promising research results, develop business plans and, where appropriate, identify and recruit management teams and venture capital syndicates. Oklahoma Manufacturing Alliance Tulsa www.okalliance.com Through its network of extension agents and applications engineers, the Oklahoma Manufacturing Alliance provides hands-on resources for improving productivity, increasing sales and reducing costs. It connects companies to local expertise and state, regional and national resources.

> memb er Oklahoma Medical Research Foundation Oklahoma City www.omrf.org Oklahoma Medical Research Foundation is a nonprofit biomedical research institute, dedicated to understanding and developing more effective treatments for human disease, focusing on such critical research areas as heart disease, cancer, lupus and Alzheimer’s disease. Oklahoma Nurses Association Oklahoma city www.oknurses.com ONA is the professional association for all registered nurses in Oklahoma. It is a community of nurses across all specialties and practice settings working to promote the profession of nursing. Oklahoma Osteopathic Association Oklahoma city www.okosteo.org The Oklahoma Osteopathic Association continues to exist to promote the causes, purposes, and goals of the osteopathic profession in Oklahoma.

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Oklahoma Pharmaceutical Association Oklahoma City www.opha.com OPHAs mission is to unite and promote the profession of pharmacy through advocacy, communication, and education. They facilitate pharmacists in the development of innovative pharmacy practices that demonstrate improved health outcomes for patients and reinforce the role of pharmacists as essential members of the healthcare team. Oklahoma Technology and Research Park Stillwater www.oktechpark.com Oklahoma Technology and Research Park is an emerging knowledge center and high-value business destination for knowledge-based companies in Stillwater, Oklahoma. Oklahoma Tobacco Settlement Trust Oklahoma City The Oklahoma Tobacco Settlement Trust approved a five-year, $30 million grant to the Stephenson Cancer center in November 2011. The new and increased research funding supports efforts at OU, OSU, the Oklahoma Medical Research Foundation and other Oklahoma institutions which are currrently conducting innovative biomedical research. Oklahoma Venture Forum Oklahoma City www.ovf.org The Oklahoma Venture Forum (OVF) is a non-profit corporation organized to encourage economic development in Oklahoma. The OVF works to increase the utilization of Oklahoma’s resources, resulting in the establishment and growth of new and existing business ventures. Oklahoma Veterinary Medical Association Oklahoma City www.okvma.org The Oklahoma Veterinary Medical Association (OVMA) is a professional trade organization for veterinarians. OMEDtech, LLC Oklahoma City www.omedtech.com OMEDtech provides quality system design, regulatory, compliance, clinical and operations consulting services that are focused on helping managers and companies meet the aggressive challenges of bringing new medical device products to market. Owens & Minor Tulsa www.owens-minor.com A world class supplier of medical surgical supplies, Owens-Minor has locations throughout the United States. Pardalis Software, Inc Stillwater www.pardalis.com Pardalis’ mission is to promote the granular sharing of confidential, trustworthy and traceable information along complex supply chains, and within the emerging data web, by empowering information owners and producers with innovative Common Point AuthoringTM methods.

PD-Rx Pharmaceuticals, Inc. Oklahoma City www.pdrx.com PD-Rx Pharmaceuticals Inc. is a pharmaceutical distributer. PetNet Pharmaceutical, Inc. Broken Arrow www.petnetsolutions.com PETNET Solutions operates the largest PET radiopharmacy network with over 47 radiopharmacies and distribution centers at multiple locations that produce and distribute PET radiopharmaceuticals to hospitals, clinics, and research facilities for PET imaging. Phillips Murrah, P.C. Oklahoma City www.phillipsmurrah.com Phillips Murrah is a full service law firm with an Intellectual Property department that handles clients around the country. Many clients find their legal costs half of what they would pay for the same services with law firms on the east or west coast. Physicians Total Care, Inc. Tulsa www.physicianstotalcare.com PTC has developed the PTC9000 software that allows physicians to dispense prescribed medications directly to patients while in the office. Ponca City Development Authority Ponca City www.goponca.com The Ponca City Development Authority helps to steer North Central Oklahoma’s dynamic economy through the support of local businesses, education and community, while fostering a climate of innovation and economic growth in one of North America’s most attractive hometowns.

> memb er Presbyterian Health Foundation Oklahoma City www.phfokc.com Presbyterian Health Foundation supports medical research by recruiting high-quality research scientists at the Oklahoma Health Center and supporting bioscience tech transfer. Price Edwards & Company Oklahoma City www.priceedwards.com Price Edwards & Company is proud to be among the leaders in Oklahoma commercial real estate. Price Edwards & Company is a full service firm headquartered in Oklahoma City. Formed in 1988, Price Edwards & Company employs approximately 150 professionals in Oklahoma City, Okla. providing commercial real estate services. Productive Technologies, LLC Oklahoma City www.productiveT.com ProductiveT has a complement of 75 experienced specialists in innovation management, asset management, and web and software solutions.

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Rural Enterprises, Inc. Ada www.ruralenterprises.com Rural Enterprises of Oklahoma, Inc. is a statewide non-profit organization with a mission to promote economic growth through the utilization of financial and business services.

The Kerr Center Poteau www.kerrcenter.com The Kerr Center is focused on finding sustainable solutions to the economic, social and environmental challenges facing Oklahoma’s farmers, ranchers and rural communities.

Saic, Inc. Midwest City www.saic.com A fortune 500 company with over 41,000 employees worldwide, Saic provides best value services and solutions based on innovative applications of science and technology.

The State Chamber of Oklahoma Oklahoma City www.okstatechamber.com The State Chamber of Oklahoma is establishing Oklahoma as a global leader in the technical, industrial and economic arenas.

Saint Francis Hospital Tulsa www.saintfrancis.com Saint Francis Health System is an integrated, medically-based health system with an emphasis on a complete continuum of care. From services for the tiniest premature newborns, to end-of-life care options, to all medical needs in between, the physicians and staff of Saint Francis treat each patient with dignity and integrity. Sigma Blood Systems, LLC Oklahoma City www.sigmablood.com Sigma Blood System’s goal is to be the leader in delivering operational efficiencies for blood centers in the collection, manufacturing, quality control and distribution processes. SMC Technologies Midwest City www.smc-technologies.com SMC Technologies, Inc. is available to provide products, consultation, services and research programs to meet water, energy, environmental, and specialty chemical needs. Southwest Nanotechnologies, Inc. Norman www.swentnano.com SWeNT is a privately held independent specialty chemical firm, manufacturing single wall carbon nanotubes for a broad array of specialty products. Southwestern Biomedical Electronics Tulsa www.swbiomed.com Southwestern Biomedical Electronics was established in 1976 as an authorized sales and service representative to distribute Spacelabs products to area hospitals in Oklahoma. Stillwater Chamber of Commerce Stillwater www.stillwaterchamber.org As a catalyst for prosperity, the Stillwater Chamber of Commerce will provide the leadership necessary to create an environment that rewards business investment in the Stillwater community. Strategic Solutions International. LLC Stillwater www.strategicsolutions.us SSI’s strategic mission is to apply sound research principles and visionary innovation to develop novel, robust, rugged solutions to significant, unsolved problems.

Tulsa Metro Chamber Tulsa www.tulsachamber.com The Tulsa Metro Chamber is the principal business-driven leadership organization improving the quality of community life through the development of regional economic prosperity. University Hospital Authority Oklahoma City www.uhatok.com The Authority and Trust provides support for important educational enhancements, for key research and health care advancements and for critical capital improvement projects on campus, including the new OU Physicians Building and phase two of the Stanton L. Young Biomedical Research Center. USDA Animal & Plant Health Inspection Service Stillwater www.aphis.usda.gov The Animal and Plant Health Inspection Service is a multi-faceted Agency with a broad mission area that includes protecting and promoting U.S. agricultural health, regulating genetically engineered organisms, administering the Animal Welfare Act and carrying out wildlife damage management activities. William K. Warren Foundation Tulsa www.williamkwarrenfoundation.org The Warren Foundation provides financial assistance in support of worthy charitable, scientific, Catholic, and health programs dedicated to improving the quality of life. The Warren Foundation primarily limits its grants to non-profit organizations in and around Tulsa, Oklahoma. WILLIS of Oklahoma Oklahoma City www.willis.com Willis is recognized as a leading global insurance broker, handling risk management and reinsurance across a wide range of service areas and industries. Willis is grounded in an entrepreneurial approach to the risk management business, with an unequaled commitment to the delivery of customized solutions.

Medical Devices Cognitive Systems, Inc. Oklahoma City www.cog-systems.com

The Cognitive Systems Teletherapy System is an innovative Internet Enabled technology that provides a clinical approach to regeneration or “rewiring” of the neurological connectivity in the brain. Compression Solutions Tulsa www.compressionsolutions.us Compression Solutions is on the forefront of preventing Deep Vein Thrombosis (DVT) where patients are most vulnerable — at home after surgery. 3DIcon Corporation Tulsa www.3dicon.net 3DIcon Corporation is a developer of groundbreaking 3D projection and display technologies that are being designed to produce full color, 360° volumetric images. Access Optics Broken Arrow www.accessoptics.com Access Optics brings together inventive manufacturing engineering, process development, leading-edge optical fabrication and advanced coating technology to deliver exceptional products. Adroit Surgical, LLC • Nichols Hills Adroit Surgical LLC is a medical device company that has developed a patented method for securing the airway in emergency situations. Medical Devices & Related All American Mold Laboratories, Inc. Oklahoma City www.allamericanmold.com All American Mold provides quality service, craftsmanship, products and materials and is one of the nation’s leading full service ear mold laboratories. Amethyst Research, Inc. Ardmore www.amethystresearch.com Amethyst Research delivers the enabling process technologies to equip its manufacturing partners to build better, cheaper, higher performance infrared focal plane arrays. Artison Corporation Inola www.artisonweb.com Artison is a medical device and biotechnology company utilizing ultrasoundenergy (nonimaging) for the fields of medicine and biotechnology. Artison designs, develops, and manufactures medical devices and biotechnology platforms that utilize ultrasound energy. Bijhem Scientific, Inc. Norman www.bijhem.com Bijhem Scientific, Inc. is an innovation centered product development corporation with a primary focus in nanomaterial based applications.

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Medical Devices contunued

CareFusion Mannford www.carefusion.com CareFusion has built a foundation of medical products and software analytics to help improve patient safety and reduce the cost of health care for generations to come.

La Fuente Prosthetics Oklahoma City www.oklahomaprosthetics.com La Fuente’s Maxillofacial and Artificial eye prosthetics are custom fitted using the newest technology available. In 2004, La Fuente Prosthetics began making prosthetic limbs.

Scott Sabolich Prosthetics and Research Oklahoma City www.scottsabolich.com The mission of Scott Sabolich Prosthetics and Research is to build a lifelong partnership with our patients and their families, providing cutting edge prosthetic care.

Clear Tone Hearing Aid Laboratories, Inc. Tulsa www.cleartonehearingaids.com Clear Tone has brought together the professional expertise of licensed hearing aid specialists, electronic engineers and electro-acoustic engineers in our own custom manufacturing lab and testing facility.

Landauer, Inc. Stillwater www.landauer.com Landauer Inc supports a stand-alone research center dedicated to aluminum oxide crystal growth production for our optically stimulated luminescence (OSL) dosimeters, as well as new crystal development to enhance our current applications.

SeboTek Hearing Systems Tulsa www.sebotek.com SeboTek Hearing Systems is a fast-growing, privately-held company that revolutionized the hearing instrument industry with it’s patented receiver in the canal (RIC) technology.

Criticare, Inc. Oklahoma City www.neochild.com Criticare offers a unique availability of custom products backed with extensive in-service capabilities to I.V. infusion teams, neonatal, pediatric, anesthesia and pharmacy departments.

Lazarus Medical, LLC Tulsa www.lazarusmed.com Lazarus Medical was started by medical professionals to design, develop, and bring to market innovative products that cost-effectively answer unmet clinical needs.

DA/PRO Rubber, Inc. Broken Arrow www.daprorubber.com Da/Pro Rubber is a manufacturer of custom medical device components ranging from components for blood analysis machines to surgical instruments.

Lifetone Technology Oklahoma City www.lifetonesafety.com Lifetone technology develops and markets proprietary, code-compliant products which provide improved alarming and alerting capability in response to emergencies as compared in existing solutions.

EKIPS Technologies, Inc. Norman www.ekipstech.com Ekips develops and sells tunable mid-infrared lasers and laser systems for molecular spectroscopy applications.

Medtrieval, LLC Oklahoma City Medtrieval LLC’s mission is to provide safe, efficient, and reliable automated medication retrieval systems for use in correctional and assisted living facilities where there are high risks for error and drug abuse.

> memb er

Exakt Technologies, Inc. Oklahoma City www.exaktusa.com EXAKT Technologies, Inc. has been providing precision laboratory equipment to research facilities for over 11 years. Hanger Prosthetics & Orthotics, Inc. Oklahoma City www.hanger.com Hanger is the largest provider of prosthetics, orthopedic supports, and braces in the United States.

> memb er Immuno-Mycologics, Inc. Norman www.immy.com Immuno Mycologics, Inc. is Oklahoma’s oldest biotechnology company, specializing in the manufacture and distribution of fungal diagnostic kits and reagents. IMMY’s products utilize conventional serological technology for antigen and antibody detection, and are produced in a GMP manufacturing facility under the auspices of the FDA. Jobri, LLC Konawa www.jobri.com Jobri manufactures ergonomic back supports, ergonomic chairs, orthopedic soft goods and sleep products.

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Spring 2014

Norris Surgical, LLC Tulsa Norris Surgical will provide a low profile periarticular tension band plating system with a soft tissue neutralization cable tunnel/channel. Essentially it acts as a fracture plate implant system for small bones. Optima TechLabs, Inc. Edmond www.optimatechlabs.com Optima TechLabs is an early-stage technology development company founded with a vision of transforming innovative ideas and concepts into marketable products. Rich-Mar, Inc. Inola www.richmarweb.com Rich-Mar provides a complete product line of ultrasound and stimulation equipment for use by health care professionals. Sanlo Orthopedics, LLC Midwest City www.sanloorthopedicsllc.com SanLo Orthopedics, LLC is a fully accredited Orthotics & Prosthetics facility by the State of Oklahoma and by The American Board for Certification in Orthotics, Prosthetics, and Pedorthics.

SensiQ Technologies, Inc. Oklahoma City www.sensiqtech.com SensiQ Technologies, Inc. develops and manufactures innovative tools for the advancement of life sciences research, including drug discovery. Smith & Nephew Dyonics, Inc. Oklahoma City www.smith-nephew.com Smith & Nephew’s three Global Business Units Orthopaedics, Endoscopy and Advanced Wound Management - have worldwide responsibility for the research and development, manufacturing and marketing of their respective product ranges. Team Effort Optical Oklahoma City www.teameffortoptical.com Team Effort Optical offers single vision lenses to the latest technology in progressive bifocals, and everything in between. Most of these products are available in Glass, CR-39, Hard Resin, High Index, and Polycarbonate. Transtimulation Research, Inc. Oklahoma City www.transtimulation.com Transtimulations Research Inc. offers a gastric electrical stimulator for reflux disease. VADovations Oklahoma City VADovations, a spin out of INTEGRIS Baptist Medical Center, is creating a miniature blood pump the size of a AAA battery, enabling less invasive surgery to implant, shortening hospitalization time from three weeks to three or four days.

Research & Educational Institutions American Cancer Society, Inc. Oklahoma City www.cancer.org American Cancer Society is a large research organization that actively participates in cancer research. American Diabetes Association Oklahoma City www.diabetes.org The American Diabetes Association is committed to educating the public about how to stop diabetes and support those living with the disease.

Medical Devices contunued CareFusion Mannford www.carefusion.com CareFusion has built a foundation of medical products and software analytics to help improve patient safety and reduce the cost of health care for generations to come.

DA/PRO Rubber, Inc. Broken Arrow www.daprorubber.com Da/Pro Rubber is a manufacturer of custom medical device components ranging from components for blood analysis machines to surgical instruments.

EKIPS Technologies, Inc. Norman www.ekipstech.com Ekips develops and sells tunable mid-infrared lasers and laser systems for molecular spectroscopy applications.

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Spring 2014

> memb er SensiQ Technologies, Inc. Oklahoma City www.sensiqtech.com SensiQ Technologies, Inc. develops and manufactures innovative tools for the advancement of life sciences research, including drug discovery. Smith & Nephew Dyonics, Inc. Oklahoma City www.smith-nephew.com Smith & Nephew’s three Global Business Units Orthopaedics, Endoscopy and Advanced Wound Management - have worldwide responsibility for the research and development, manufacturing and marketing of their respective product ranges. Team Effort Optical Oklahoma City www.teameffortoptical.com Team Effort Optical offers single vision lenses to the latest technology in progressive bifocals, and everything in between. Most of these products are available in Glass, CR-39, Hard Resin, High Index, and Polycarbonate. Transtimulation Research, Inc. Oklahoma City www.transtimulation.com Transtimulations Research Inc. offers a gastric electrical stimulator for reflux disease. VADovations Oklahoma City VADovations, a spin out of INTEGRIS Baptist Medical Center, is creating a miniature blood pump the size of a AAA battery, enabling less invasive surgery to implant, shortening hospitalization time from three weeks to three or four days.

American Drug Utilization Edmond www.adurs.com The mission of ADURS is to provide a forum of leadership and support for the individuals active in drug utilization review to obtain information, develop skills, and receive training to efficiently and effectively perform their duties. American Indian Diabetes Prevention Center Oklahoma City www.ndndiabetes.ouhsc.edu The American Indian Diabetes Prevention Center will reduce the excess mortality and morbidity of diabetes so that quality of life and cultural vitality is made secure. American Institute of Medical Technology Tulsa www.aimt.edu AIMT believes in providing superior professional and technical preparation by offering students modern technology equipment and methods of study. American Osteopathic Academy of Orthopedics www.aoao.org The American Osteopathic Academy of Orthopedics facilitates the finest training and continuous development of Osteopathic Orthopedic Surgeons to positively improve the care, healing and quality of life of patients.

> m em ber Dean McGee Eye Institute Oklahoma City www.dmei.org The Dean McGee Eye Institute is one of only a small handful of institutions in the Southwest and Midwest which offers a complete spectrum of subspecialty eye care for everything from tumors to macular degeneration as well as a nationally-ranked vision research enterprise.

Hough Ear Institute Oklahoma City www.houghear.org Hough Ear Institute personnel conduct research, provide education and serve humanitarian needs relating to hearing and balance improvement or restoration. Meridian Technology Center Stillwater www.meridiantech.edu From innovative full-time courses to services for business and industry, Meridian Technology’s mission is to provide up to date information on the most current technological and management advances available.

> m em ber Oklahoma City Community College Oklahoma City www.occc.edu/BiologyLab The BSC is an interdisciplinary area designed to accommodate the independent study needs of students in the biological sciences. Oklahoma City University Oklahoma City www.okcu.edu Oklahoma City University is affiliated with the United Methodist Church and offers a wide variety of degrees in the liberal arts and sciences disciplines, including Biology, Biomedical Science, and Cell & Molecular Biology. Oklahoma Department of Career and Technology Education Stillwater www.okcareertech.org The CareerTech system is advancing Oklahoma’s bioscience industry by implementing workforce development initiatives such as biomedical academies, biotechnology and nanotechnology training, as well as providing customized training and services.

Oklahoma Foundation for Digestive Research Oklahoma City Francis Tuttle- Biosciences www.ofdr.org and Medicine Academy OFDR’s mission is to advance basic science and Oklahoma City clinical research in gastrointestinal disease, treat www.francistuttle.edu patients with such diseases, participate in the The Biosciences and Medicine Academy is training of physicians, and to educate the public designed to prepare high school sophmores about gastrointestinal illnesses. and juniors for success in college. Oklahoma Medical Research Foundation Harold Hamm Oklahoma Diabetes Center Oklahoma City Oklahoma City www.omrf.org www.hhodc.ouhsc.edu Oklahoma Medical Research Foundation is a The Harold Hamm Oklahoma Diabetes Center nonprofit biomedical research institute, dedicated is a program established by the University of to understanding and developing more effective Oklahoma with the goal of promoting the welltreatments for human disease, focusing on such being of all people with, or at high risk of, diabetes critical research areas as heart disease, cancer, in Oklahoma, regardless of ethnic background or lupus and Alzheimer’s disease. financial status. Oklahoma State Regents Helmerich Research Center at Oklahoma for Higher Education State University Tulsa Oklahoma City Tulsa www.okhighered.org www.osu-tulsa.okstate.edu/helmerich/index.php The Regents provide information, OSU-Tulsa’s Helmerich Research Center provides communication, collaboration and training opportunities for students to receive a world-class about grantsmanship for Oklahoma higher engineering education at an affordable price in a education. Partnerships between higher education state-of-the-art research facility in Tulsa. institutions and community organizations and corporate entities are encouraged and supported.

> member Oklahoma State University Stillwater www.okstate.edu OSU is one of the nation’s most comprehensive land-grant systems dedicated to providing students with an education to prepare them for success. OSU students and faculty are working to find solutions through the diverse programs and opportunities in research and technology. OSU Biobased Products and Energy Center Stillwater www.bioenergycenter.okstate.edu OSU continues to expand research efforts, addressing the critical issues in further establishing renewable energy industries. Areas of emphasis include enhancing productivity of potential feedstocks, improving conversion technologies, and optimizing the value of coproducts and by-products. OSU Center for Engineering in Logistics and Distribution Stillwater http://lfp.okstate.edu/celdiokstate.edu/celdi CELDi helps industry partners excel by leveraging their supply chain to achieve a distinguishable, sustainable difference. OSU Center for Health Sciences Tulsa www.healthsciences.okstate.edu OSU Center for Health Sciences educates osteopathic physicians, research scientists and other health care professionals with emphasis on serving rural and under-served Oklahomans. OSU Henry Bellmon Research Center Stillwater www.hbrc.okstate.edu The HBRC is OSU-Stillwater’s only building dedicated exclusively to research. Designed with modern features, this state-of-the-art facility brings together researchers from different departments who collaborate on projects at the cutting-edge of modern research. OSU Institute of Technology Okmulgee www.osuit.edu OSU Institute of Technology is a public, statesupported technical institution committed to increasing the potential and productivity of the people it serves. OSU Microscopy Laboratory Stillwater www.microscopy.okstate.edu Oklahoma State University Microscopy Laboratory is a highly specialized research support and teaching lab that uses some of the most powerful microscopes ever developed to peek into the very molecular structure of all kinds of materials. OSU Office of Research and Technology Transfer Stillwater www.vpr.okstate.edu OSU Office of Research and Technology Transfer provides access to a variety of research and technology services at OSU including intellectual property management, proposal development, university reseach services, collaboration and partnership development. Spring 2014 i&E

Research and Educational Institutions contunued OSU Oklahoma City Oklahoma City www.osuokc.edu OSU-Oklahoma City responds to students’ career aspirations and current business and industry workforce development needs by offering Associate in Science and applied science degree programs, certificate programs and general education programs. OSU Technology Development Center Stillwater http://tdc.okstate.edu The Technology Development Center (TDC) at Oklahoma State University assists faculty and staff members, administrators, and students with intellectual property issues resulting from their scholarly and creative activities. OSU Tulsa Tulsa www.osu-tulsa.okstate.edu OSU Tulsa is a public, nationally recognized comprehensive research university that offers junior, senior and graduate-level classes. OUHSC Center for American Indian Health Research Oklahoma City http://caihr.ouhsc.edu The Center for American Indian Health Research performs research and health-related studies with American Indian groups. OUHSC Center for Biosecurity Research Oklahoma City www.cbr.ouhsc.edu The Center for Biosecurity Research at the University of Oklahoma Health Sciences Center is committed to conducting scientific research, assessing and modeling risks, and developing decision support tools that enhance U.S. military force protection and homeland security. OUHSC DNA Sequencing/Genomics Oklahoma City www.genetics.ouhsc.edu The Laboratory for Genomics and Bioinformatics is a core facility offering an array of services aimed at facilitating the research of a variety of different investigators across a multitude of disciplines. OUHSC Lab for Molecular Biology and Cytometry Research Oklahoma City www.microgen.ouhsc.edu The Laboratory for Molecular Biology and Cytometry Research is a state of the art facility offering a variety of services in the areas of DNA sequencing/genomics, mass spectrometry/ proteomics and flow cytometry and imaging. OUHSC Oklahoma Center for Neuroscience Oklahoma City www.oumedicine.com/ocns The OUHSC Oklahoma Center ofr Neuroscience advances the science and understanding of brain-gut interactions by pursuing interdisciplinary synergistic collaborations to take advantage of cutting edge technologies, and innovative research approaches to treat gastrointestinal disorders.

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OUHSC Reynolds Oklahoma Center on Aging Oklahoma City www.oumedicine.com/roca ROCA researchers excel in the basic sciences of aging and are able to translate their information from the laboratory bench to understanding aging and age-related diseases in humans. OUHSC The Flow and Image Cytometry Laboratory Oklahoma City http://research.ouhsc.edu/core-facilities/flowcytometry-and-imaging-2/ The Flow and Image Cytometry Laboratory provides the University of Oklahoma research community with state-of-the-art cell analysis and sorting instrumentation, and the technical expertise to best utilize this technology. Redlands Community College El Reno www.redlandscc.edu Redlands Community College provides a learnercentered environment committed to academic excellence strengthened through service and civic engagement. The Redlands offer various associate degree programs in Science. Rogers State University Department of Biology Claremore www.rsu.edu/academics/biology The Department of Biology at Rogers State offers a diverse combination of traditional laboratory and empirically based components of biological sciences. Rose State College Health Services Division Midwest City www.rose.edu/health-sciences1 Rose State currently offers eight Allied Health, Nursing and Allied Dental programs facilitating entry into the exciting and rewarding world of health care.

> m e m be r Samuel Roberts Noble Foundation Ardmore www.noble.org The Noble Foundation is an independent, nonprofit institute conducting plant science research and agricultural programs to enhance agricultural productivity. Founded in 1945 by Lloyd Noble, the Noble Foundation’s early efforts focused on educating and encouraging area farmers and ranchers to practice land stewardship and resource conservation. The Sickle Cell Cure Foundation Oklahoma City www.sicklecellcurefoundation.org Sickle Cell Disease (SCD) affects more people in the world than any other genetic disease. Globally, almost one-half million babies die from SCD each year. The SCCF has discovered a treatment that promises permanent relief from the suffering, pain and premature death caused by SCD. Tulsa Community College Tulsa www.tulsacc.edu TCC offers three biotechnology degree programs. They also have been awarded NSF and NIH ARRA funds to develop outreach biotechnology academies to regional secondary schools. TCC

is amoung the top 50 community colleges in the nation in granting associate degrees in health professions and related clinical sciences. Tulsa Technology Center Tulsa www.tulsatech.edu Tulsa Tech is a career and technology center school district dedicated to preparing people for success in the workplace. Tulsa Tech helps high school and adult students from accross the Tulsa region explore new careers, upgrade their training and skills, and pursue their dreams. Tulsa Technology Center Biomedical Sciences Program Tulsa www.tulsatech.com Students with interest in exploring the variety of occupations that medicine offers will find Project Lead the Way’s Biomedical Sciences program a fantastic doorway to a future in the industry. University of Central Oklahoma Edmond www.uco.edu The Biomedical Engineering program works to provide students with a fundamental education in health science and biomedical engineering, allowing them to learn and adapt new technologies to solve health related problems in an ever-changing workplace. University of Oklahoma Norman www.ou.edu OU provides the best possible educational experience for their students through excellence in teaching, research and creative activity, and service to the state and society. OU has diverse and integrated bioscience and technology degree programs, research projects, facilities and nation and internaitonal partnerships. University of Oklahoma Advanced Center for Genome Technology Norman www.genome.ou.edu The (ACGT) is a world class Genome Center applying high throughput, state-of-the-art DNA sequencing technology and computer-based automated genome annotation to address important and significant biological, biomedical and agricultual problems at the genome level. University of Oklahoma Bioengineering Center Norman www.oubc.ou.edu OUBC offers a wide range of courses in bioengineering as well as research opportunities in the application of technology to biological systems. University of Oklahoma Center for Electromagnetic Compatibility Norman www.ou.edu/engineering/emc The University of Oklahoma Center for Electromagnetic Compatibility’s goal is to serve as an independent center dedicated to the investigation of issues related to the electromagnetic compatibility of electronic equipment with wireless devices.

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> m em ber University of Oklahoma Health Sciences Center Oklahoma City www.ouhsc.edu OUHSC educates students to become highly qualified health services practitioners, educators, and research scientists; to conduct research and creative activities for the advancement of knowledge through teaching and development of skills; and to provide continuing education, public service, and clinical care of exemplary quality. University of Oklahoma Intellectual Property Management Norman www.otd.ou.edu The University of Oklahoma Intellectual Property Management Office administers the university’s Intellectual Property policy and is responsible for economic development and technologyrelated activities, including private industry and governmental relationships. University of Oklahoma Schusterman Center Tulsa www.ou.edu/content/tulsa The University of Oklahoma Tulsa Schusterman Center is a research and learning campus that offers Bachelor and advance degrees in nursing, medical imaging, physical therapy, public health, pharmacy and other medical and non-medical programs. The Center includes the Oklahoma Diabetes Center and the Oklahoma Bioethics Center. University of Oklahoma Stephenson Life Sciences Research Center Norman http://srtc.ou.edu The Stephenson Life Sciences Research Center houses the research and administrative functions of the Department of Chemistry and Biochemistry as well as a number of chemists, biochemists and other life science researchers. University of Tulsa Tulsa www.utulsa.edu Ranked among the nations Top 100 Universities, The University of Tulsa is a private, comprehensive doctoral, research university. The Institute of Bioinformatics and Computational Biology at the University of Tulsa maintains a vision of excellence in education, research and service in the emerging fields of bioinformatics and computational biology.

Research and Testing Aegis Food Testing Laboratories Oklahoma City www.aegisfoodtestinglabs.com Aegis Food Testing Labs provides ISO 17025 accredited independent microbiological and chemical testing services. COR Clinical Research, LLC Oklahoma City www.corclinical.com COR Clinical Research is a medical research facility that is dedicated to finding new medical treatments, medications and other options for treating diseases and disorders.

Fractionation Research, Inc. Stillwater www.fri.org Fractionation Research, Inc. (FRI) is a nonprofit research consortium supported by memberships which include many of the largest petroleum, chemical, and engineering companies in the world.

Vetpath Laboratory Tulsa www.vetpathlab.com VetPath is a national, full-service vet path lab offering veterinary vet diagnostic, veterinary vet consultative services, and veterinary vet Coggins - EIA (Equine Infectious Anemia) testing to vets, DVMs, and the veterinary profession.

Legacy Clinical Research Oklahoma City Legacy Clinical Research conducts clinical trials in many different therapeutic areas. Our physicians and research professionals who conduct these trials are committed to providing you with quality patient care and medical attention.

OKBio Advisory Board

Lynn Health Science Institute Oklahoma City www.lhsi.net In operation since 1989, the Lynn Health Science Institute (LHSI) is an innovative site for comprehensive medical research. Red River Medical Research Center Oklahoma City www.redriverokc.com Red River Medical Research Center specializes in Phase 2, 3 and 4 clinical trials in psychiatry and neurology. Regional Medical Laboratory Tulsa www.rmlonline.com Regional Medical Laboratory is a nationallyrenowned commercial pathology laboratory that provides testing services for thousands of physicians and hospitals within a four-state region. Tulsa Clinical Research, LLC Tulsa www.tulsaclinicalresearch.com Tulsa Clinical Research, LLC has participated in a large number of pivotal multicenter trials investigating areas such as Alzheimer’s disease, Parkinson’s disease, stroke, seizures, multiple sclerosis, painful neuropathy, narcolepsy, attention deficit disorder (ADHD), depression, anxiety, schizophrenia, migraine, AIDS, and various other conditions.

Veterinarian Medicine & Related Cobb-Vantress, Inc. Spavinaw www.cobb-vantress.com Cobb-Vantress is a global company using innovative research and technology to make protein available, healthy and affordable worldwide. Quality Liquid Feeds Muskogee www.qlf.com QLF is a nationwide manufacturer of liquid feed supplements for animals or liquid feed for cattle. They are a family owned company who produces molasses cattle feed. SolidTech Animal Health, Inc. Newcastle www.solidtechah.com SolidTech has developed two proprietory delivery systems for administering vaccines to livestock. One for chute side delivery and one for rifle delivery. SolidTech has also developed a brand of time released vaccines.

Chris Anoatubby Chickasaw Nation Division of Commerce Sean Bauman Immuno-Mycologics, Inc. Bill Buckner The Samuel Roberts Noble Foundation Paul DeAngelis Hyalose LLC Carl Edwards Presbyterian Health Foundation Darren Head Cytovance Biologics P. Lloyd Hildebrand Oklahoma University Health Sciences Center John Iandolo Oklahoma University Health Sciences Center Thomas Kupiec Analytical Research Laboratories and DNA Solutions Stephen McKeever Oklahoma State University and the State of Oklahoma Stephen Prescott Oklahoma Medical Research Foundation Scott Rollins Selexys Pharmaceuticals Craig Shimasaki Moleculera Labs Jim Turner Astellas Pharma Roy H. Williams Greater Oklahoma City Chamber Mickey Young Hall Estill

Annual Sustaining Sponsors Chickasaw Nation Greater Oklahoma City Chamber Oklahoma Business Roundtable Oklahoma Department of Commerce Oklahoma Medical Research Foundation Oklahoma State University Presbyterian Health Foundation The Samuel Roberts Noble Foundation

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“3rd-best post-recession recovery” -Brookings Institution

“Second-best for small business” -The Business Journals

“Among the fastest-growing cities in the U.S.” -Forbes”

“Top 10 for economic momentum in 2014” -New Geography

“OKC is a boomtown” -Bloomberg

“Among the top 12 brainiest metros” -The Atlantic Cities

D OW N TOW N O K L A H O M A C I T Y ’ S B I O C LU ST E R

OKLAHOMA CITY CULTIVATES

TAKING OFF: In OKC, we’ve found that our combination of assets important to biotech researchers, executives and entrepreneurs, like high-quality, low-cost facilities; access to talent via our 125,000 college students; low costs of living and doing business; innovative grant and investment programs; and our collaborative, supportive business environment have all helped fuel our growth. From medical devices and new drug therapies to disease research and tech innovations, our biotech community has discovered just why we say in OKC, it’s a better living and a better life. Check us out— and you could be the next to beneﬁt from our success.

Explore OKC’s online channel and website at GreaterOKC.tv

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