A020110108

International Journal of Engineering Inventions e-ISSN: 2278-7461, p-ISSN: 2319-6491 Volume 2, Issue 11 (July 2013) PP: 01-08

The Finite Difference Methods And Its Stability For Glycolysis Model In Two Dimensions Fadhil H. Easif1, Saad A. Manaa2 1,2

Department of Mathematics, Faculty of Science, University of Zakho, Duhok, Kurdistan Region, Iraq

Abstract: The Glycolysis Model Has Been Solved Numerically In Two Dimensions By Using Two Finite Differences Methods: Alternating Direction Explicit And Alternating Direction Implicit Methods (ADE And ADI) And We Were Found That The ADE Method Is Simpler While The ADI Method Is More Accurate. Also, We Found That ADE Method Is Conditionally Stable While ADI Method Is Unconditionally Stable.

Keywords: Glycolysis Model, ADE Method, ADI Method.

I.

INTRODUCTION

Chemical reactions are modeled by non-linear partial differential equations (PDEs) exhibiting travelling wave solutions. These oscillations occur due to feedback in the system either chemical feedback (such as autocatalysis) or temperature feedback due to a non-isothermal reaction.

Reaction-diffusion (RD) systems arise frequently in the study of chemical and biological phenomena and are naturally modeled by parabolic partial differential equations (PDEs). The dynamics of RD systems has been the subject of intense research activity over the past decades. The reason is that RD system exhibit very rich dynamic behavior including periodic and quasi-periodic solutions and chaos(see, for example [8].

1.1. MATHEMATICAL MODEL: A general class of nonlinear-diffusion system is in the form đ?œ•đ?‘˘ = đ?‘‘1 ∆đ?‘˘ + đ?‘Ž1 đ?‘˘ + đ?‘?1 đ?‘Ł + đ?‘“ đ?‘˘, đ?‘Ł + đ?‘”1 đ?‘Ľ đ?œ•đ?‘Ą đ?œ•đ?‘Ł = đ?‘‘2 ∆đ?‘˘ + đ?‘Ž2 đ?‘˘ + đ?‘?2 đ?‘Ł − đ?‘“ đ?‘˘, đ?‘Ł + đ?‘”2 đ?‘Ľ đ?œ•đ?‘Ą

(1)

with homogenous Dirchlet or Neumann boundary condition on a bounded domain ℌ , n≤3, with locally Lipschitz continuous boundary. It is well known that reaction and diffusion of chemical or biochemical species can produce a variety of spatial patterns. This class of reaction diffusion systems includes some significant pattern formation equations arising from the modeling of kinetics of chemical or biochemical reactions and from the biological pattern formation theory.

In this group, the following four systems are typically important and serve as mathematical models in physical chemistry and in biology:  Brusselator model: đ?‘Ž1 = − đ?‘? + 1 , đ?‘?1 = 0, đ?‘Ž2 = đ?‘?, đ?‘?2 = 0, đ?‘“ = đ?‘˘2 đ?‘Ł, đ?‘”1 = đ?‘Ž, đ?‘”2 = 0,



where a and b are positive constants.

Gray-Scott model: đ?‘Ž1 = − đ?‘“ + đ?‘˜ , đ?‘?1 = 0, đ?‘Ž2 = 0, đ?‘?2 = −đ??š, đ?‘“ = đ?‘˘2 đ?‘Ł, đ?‘”1 = 0, đ?‘”2 = đ??š,

  

where F and k are positive constants.

Glycolysis model: đ?‘Ž1 = −1, đ?‘?1 = đ?‘˜, đ?‘Ž2 = 0, đ?‘?2 = −đ?‘˜, đ?‘“ = đ?‘˘2 đ?‘Ł, đ?‘”1 = đ?œŒ, đ?‘”2 = đ?›ż,

where đ?‘˜, đ?‘?, and đ?›ż are positive constants Schnackenberg model: đ?‘Ž1 = −đ?‘˜, đ?‘?1 = đ?‘Ž2 = đ?‘?2 = 0, đ?‘“ = đ?‘˘2 đ?‘Ł, đ?‘”1 = đ?‘Ž, đ?‘”2 = đ?‘?,

where k, a and b are positive constants.

Then one obtains the following system of two nonlinearly coupled reaction-diffusion equations (the Glycolysis model), đ?œ•đ?‘˘ = đ?‘‘1 ∆đ?‘˘ − đ?‘˘ + đ?‘˜đ?‘Ł + đ?‘˘2 đ?‘Ł + đ?œŒ, đ?‘Ą, đ?‘Ľ ∈ 0, ∞ Ă— â„Ś đ?œ•đ?‘Ą đ?œ•đ?‘Ł = đ?‘‘2 ∆đ?‘Ł − đ?‘˜đ?‘Ł − đ?‘˘2 đ?‘Ł + đ?›ż, đ?‘Ą, đ?‘Ľ ∈ 0, ∞ Ă— â„Ś đ?œ•đ?‘Ą đ?‘˘ đ?‘Ą, đ?‘Ľ = đ?‘Ł đ?‘Ą, đ?‘Ľ = 0, đ?‘ĄËƒ0, đ?‘Ľđ?œ–đ?œ•â„Ś đ?‘˘ 0, đ?‘Ľ = đ?‘˘0 đ?‘Ľ , đ?‘Ł 0, đ?‘Ľ = đ?‘Ł0 đ?‘Ľ , đ?‘Ľđ?œ–â„Ś

(2)

where đ?‘‘1 , đ?‘‘2 , đ?‘?, đ?‘˜ đ?‘Žđ?‘›đ?‘‘ đ?›ż are positive constants [9]. www.ijeijournal.com

Page | 1

The Finite Difference Methods and Its Stability for Glycolysis Model in Two Dimensions II.

MATERIALS AND METHODS

2.1. Derivation Of Alternating Direction Explicit (ADE) For Glycolysis Model: The two dimensional Glycolysis model is given by đ?œ•đ?‘˘ = đ?‘‘1 đ?œ•đ?‘Ą đ?œ•đ?‘Ł = đ?‘‘2 đ?œ•đ?‘Ą

đ?œ•2đ?‘˘ đ?œ•2 đ?‘˘ + − đ?‘˘ + đ??žđ?‘Ł + đ?‘˘2 đ?‘Ł + đ?œŒ, đ?œ•đ?‘Ľ 2 đ?œ•đ?‘Ś 2 đ?œ•2đ?‘Ł đ?œ•2 đ?‘Ł + − đ??žđ?‘Ł − đ?‘˘2 đ?‘Ł + đ?‘‘đ?‘’đ?‘™, đ?œ•đ?‘Ľ 2 đ?œ•đ?‘Ś 2

(đ?‘Ą, đ?‘Ľ) ∈ (0, ∞) Ă— Ί (2) (đ?‘Ą, đ?‘Ľ) ∈ (0, ∞) Ă— Ί

We consider a square region 0≤x≤1, 0≤y≤1 and u, v are known at all points within and on the boundary of the square region. We draw lines parallel to x, y, t–axis as x=ph, y=qk, and t=nz, p,q=0, 1, 2,‌,M and n=0, 1, 2,‌, N, where h=δx, k= δy, z= δt.

Denote the values of u at these mesh points by u ( ph, qk , nz )  u p,q,n and v( ph, qk , nz )  v p,q,n . The explicit finite difference representation of the Glycolysis model is u p , q , n 1  u p , q , n

d1



z

2

h

v p , q , n 1  v p , q , n



z

d2 2

h

2 (u p 1, q , n  2u p , q , n  u p 1, q , n  u p , q 1, n  2u p , q , n  u p , q 1, n )  u p , q , n  Kv p , q , n  u p , q , n v p , q , n  ď ˛ 2 ( v p 1, q , n  2v p , q , n  v p 1, q , n  v p , q 1, n  2v p , q , n  v p , q 1, n )  Kv p , q , n  u p , q , n v p , q , n  del,

and u p , q , n 1  u p , q , n 

v p , q , n 1  v p , q , n 

d1 z h

2

d2z h

2

mi 

Assume that h=k and

2 (u p 1, q , n  2u p , q , n  u p 1, q , n  u p , q 1, n  2u p , q , n  u p , q 1, n )  zu p , q , n  zKv p , q , n  zu p , q , n v p , q , n  ď ˛z 2 ( v p 1, q , n  2v p , q , n  v p 1, q , n  v p , q 1, n  2v p , q , n  v p , q 1, n )  zKv p , q , n  zu p , q , n v p , q , n .  del

di z , i  1, 2.

2 h

Then simplifying the system to obtain

2 u p , q , n 1  u p , q , n  m1 (u p 1, q , n  2u p , q , n  u p 1, q , n  u p , q 1, n  2u p , q , n  u p , q 1, n )  zu p , q , n  zKv p , q , n  zu p , q , n v p , q , n  ď ˛z 2 v p , q , n 1  v p , q , n  m 2 ( v p 1, q , n  2v p , q , n  v p 1, q , n  v p , q 1, n  2v p , q , n  v p , q 1, n )  zKv p , q , n  zu p , q , n v p , q , n  del,

and 2 u p ,q , n 1  (1  4 m1  z ( B  1))u p , q , n  m1 (u p 1, q , n  u p 1,q , n  u p ,q 1,n  u p ,q 1, n )  zu p , q , n z  zKv p , q , n  zu p , q , n v p ,q ,n  ď ˛z 2 v p , q , n 1  (1  4 m 2 ) v p ,q , n  ( v p 1, q , n  u p 1,q , n  u p ,q 1,n  u p ,q 1, n ) m 2  zKv p , q , n  zu p , q , n v p , q , n .  del

This is the alternating direction explicit formula for the Glycolysis model Derivation Of Alternating Direction Implicit (ADI)For Glycolysis Model: In the ADI approach, the finite difference equations are written in terms of quantities at two x levels.

However, two different finite difference approximations are used alternately, one to advance the calculations from the plane n to a plane n+1, and the second to advance the calculations from (n+1)-plane to the (n+2)plane by replacing

đ?œ•2đ?‘˘ đ?œ•đ?‘Ľ 2

u p ,q ,n1  u p,q,n



z

and

đ?œ•2đ?‘Ł đ?œ•đ?‘Ľ 2

by implicit finite difference approximation [5]. we get

d1 d (u  2u p ,q ,n1  u p 1,q,n1 )  1 (u p,q 1,n  2u p,q,n  u p,q 1,n )  u p,q,n  Kv p ,q,n  2 p 1,q,n1 2 k

h

2 u p ,q ,n v p ,q ,n  ď ˛ , v p ,q ,n1  v p ,q ,n



z

d2 d 2 (v  2v p,q,n1  v p 1,q,n1 )  2 (v p ,q 1,n  2v p,q,n  v p,q 1,n )  Kv p,q,n  u p,q,n v p,q,n  del, 2 p 1,q,n1 2 h K

and u p,q,n 2  u p,q,n1



z

d1 d1 (u  2u p ,q,n1  u p 1,q,n1 )  (u  2u p ,q ,n 2  u p,q 1,n 2 )  u p,q,n  Kv p ,q,n  2 p 1,q,n 1 2 p,q 1,n 2 k

h

2 u p ,q ,n v p ,q ,n  ď ˛ , v p,q,n 2  v p,q,n1 z



d2 d2 2 (v  2v p,q ,n 1  v p 1,q,n 1 )  (v  2v p ,q ,n 2  v p,q 1,n 2 )  Kv p,q ,n  u p,q ,n v p ,q ,n  del.

2 p 1,q ,n 1 2 p,q 1,n 2 h K

www.ijeijournal.com

Page | 2

The Finite Difference Methods and Its Stability for Glycolysis Model in Two Dimensions Simplifying the system will give u p,q,n1 

d1 z d 1z 2 (u p 1,q,n1  2u p,q,n1  u p 1,q,n1 )  (u p,q 1,n  2u p,q,n  u p,q 1,n )  zu p,q,n  zu p,q,n v p,q,n  zKv p,q,n 2 2 h k

z  u p,q,n v p,q,n1 

d2z d2z 2 (v p 1,q,n1  2v p,q,n1  v p 1,q,n1 )  (v  2v p,q,n  v p,q 1,n )  Kv p,q,n  zu p,q,n v p,q,n  zv p,q.n1  zdel.

2 2 p,q 1,n h K

From the second two equations we will obtain a system of the form dz dz 2 u p,q,n  2  1 (u p 1,q,n 1  2u p,q, n 1  u p 1,q,n 1)  1 (u p,q 1,n  2  2u p,q, n  2  u p,q 1,n  2)  zu p,q, n  zu p,q, nv p, q,n  zKv p,q,n 2 2 h k

z  u p,q,n d z d z 2 v p,q,n  2  2 (v p 1,q,n 1  2v p,q, n 1  v p 1,q,n 1)  2 (v p,q 1,n  2  2v p,q, n  2  v p,q 1,n  2 )  zKv p,q,n  zu p,q,nv p,q, n  zv p,q,n 1  zdel.

2 2 h k

From the first two equations where

d z d z d z r1  1 , r2  1 , m1  2 2 2 2 h k h

and

m2 

d2z 2 k

, we get

u p,q,n1  r1 (u p 1,q,n1  2u p,q,n1  u p 1,q,n1 )  r2 (u p,q 1,n  2u p,q,n  u p,q 1,n )  zu p,q,n  zKv p,q,n 2 zu p,q,n v p,q,n  z  u p,q,n , v p,q ,n1  m1 (v p 1,q,n1  2v p,q,n1  v p 1,q,n1 )  m 2 (v p,q 1,n  2v p,q,n  v p,q 1,n )  zKv p,q,n  2 zu p,q,n v p,q,n  zdel  v p,q.n ,

and this implies that 2 u p,q,n1  r1 (u p1,q,n1  2u p,q,n1  u p 1,q,n1 )  r2 (u p,q 1,n  u p,q 1,n )  (1  2r1  z )u p,q,n  zu p,q,n v p,q,n  z  zKv p,q,n 2 v p,q,n1  m1 (v p 1,q,n1  2v p,q,n1  v p 1,q,n1 )  m2 (v p,q 1,n  v p,q1,n )  (1  2m2 )v p,q,n  zu p,q,n v p,q,n .  zdel

We have simplifying these systems of equations yields (1  2r1 )u p , q , n 1  r1 (u p 1, q , n 1  u p 1, q, n 1 )  r2 (u p , q 1, n  u p , q 1, n )  (1  2r2  z )u p, q, n  2

z  zKv p, q, n  zu p, q, n v p, q, n (1  2m1 )v p , q , n 1  m1 (v p 1, q, n 1  v p 1, q, n 1 )  m2 (v p, q 1, n  v p , q 1, n )  (1  2m2 )v p , q, n  2 zu p , q , n v p , q, n ,

also the second system of equations, yields (1  2 r2 )u p ,q ,n2  r1 (u p 1,q ,n1  u p 1,q ,n1 )  (1  2 r1 )u p ,q ,n1  r2 (u p ,q 1,n2  u p ,q 1,n2 )  zu p ,q ,n  2 zu p ,q ,n v p ,q ,n  zKv p ,q ,n  z (1  2 m2 )v p ,q ,n2  m1 (v p 1,q ,n1  v p 1,q ,n1 )  (1  2 m1 )v p ,q ,n1  m2 (v p ,q 1,n2  v p ,q 1,n2 )  2 zu p ,q ,n v p ,q ,n  zdel.

The last two systems represent Alternating Direction implicit under the conditions u1, q, n 1  u1, q 1, n 1  0 u M , q, n 1  u M , q 1, n 1  0.

Also we have

v1,q ,n 1  v1,q 1,n 1  0 v M ,q ,n 1  v M ,q 1,n 1  0.

The tridiagonal matrices for the system in the level n advanced to the level n+1, for both u and v can be formulated as follows AU=B. (1  2r1 )   r1  0   0  .  .  .   .  .  0   0

 r1 (1  2 r1 )  r1

0

0

0

.

.

.

 r1

0

0

0

0

0

0

0

0

(1  2 r1 )

 r1 0 (1  2 r1 )  r1  r1 .

0

 r1

0

0

.

0

0

.

.

.

.

.

0

0

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0

0

0

0

0

0

0

0

0  r1 (1  2 r1 ) 0 0  r1

.

www.ijeijournal.com

   0       .   .  r1   (1  2 r1 )  0 0

 u 2,q ,n1   u   3,q ,n1   u 4,q ,n1   u 5,q 1    .   .     .      u n3,q 1   u n2,q 1  u   M 1,q ,n1 

=

Page | 3

The Finite Difference Methods and Its Stability for Glycolysis Model in Two Dimensions 2   z  r2 (u 2,q 1,n  u 2,q 1,n )  (1  2 r2  z )u 2,q ,n  zu 2,q ,n v 2,q ,n   2   z  r2 (u 3,q 1,n  u 3,q 1,n )  (1  2 r2  z )u 3,q ,n  zu 3,q ,n v3,q ,n   2   z  r2 (u 4,q 1,n  u 4,q 1,n )  (1  2 r2  z )u 4,q ,n  zu 4,q ,n v 4,q ,n         .   .   .   .           2  z  r (u   u )  ( 1  2 r  z ) u  zu v M  1 , q , n 2 M 1,q 1,n M 1,q 1,n 2 M 1,q ,n M 1,q ,n  

(1  2m1 )   m1  0   0  .  .  .   .  .  0   0

 m1

(1  2m1 )  m1

0

0

0

.

.

.

 m1 (1  2m1 )

0

0

0

0

0

 m1

0

0

0

0

0

 m1

(1  2m1 )  m1  m1 . .

0

0

.

0

0

.

.

.

.

.

0

0

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0

0

0

0

0  m1 (1  2m1 )

0

0

0

0

0

0

 m1

 0   0       .  .   m1   (1  2 m1 )  0

 v 2,q ,n1   v   3,q ,n1   v 4,q ,n1   v5,q ,n1    .   .  =   .      v M 3,q ,n1  v M 2,q ,n1  v   M 1,q ,n1 

2   m 2 (v 2,q 1,n  v 2,q 1,n )  (1  2 m 2  zK )v 2,q,n  zu 2,q,n v 2,q,n   2   m 2 (v3,q 1,n  v3,q 1,n )  (1  2 m 2  zK )v3,q,n  zu 3,q,n v3,q,n   2 m 2 (v 4,q 1,n  v 4,q 1,n )  (1  2 m 2  zK )v 4,q,n  zu 4,q,n v 4,q,n       .   .     .   .           2 m 2 (v M 1,q 1,n  v M 1,q 1,n )  (1  2m 2  zK )v M 1,q,n  zu M 1,q,n v M 1,q,n 

And the tridiagonal matrices for the system in level n+1 advanced to level n+2 for both u and v are given by AU=B. 0 0 0 . . .

0   u (1  2r2 )  r2 p , 2,n  2    r2 (1  2r2 )  r2  0 0 0 0 0 0   u  0   p,3,n2   r1 (1  2r1 )  r1 0 0 0 0 0    u p , 4,n  2  0  r2 (1  2r2 )  r2  0   u p ,5,n2   0 0  r2 . .  .  . =  .  .

0 0 . . . .    .  . .

0 0 . . .  .    . . . . . . . .    .   . . . . . . . . .  u  p ,M 3,n 2   0  0 0 0 0 0  r2 (1  2r2 )  r2   u p , M  2 , n  2   0 0 0 0 0 0  r2 (1  2r2 )   u  0 p ,M 1,n 2 

www.ijeijournal.com



Page | 4

The Finite Difference Methods and Its Stability for Glycolysis Model in Two Dimensions 2 ďƒŠ ďƒš ď ˛z  r1 (u p 1,2,n1  u p 1, 2,n1 )  (1  2r1  z )u p, 2,n1  zu p,2,n  zu p,2,n v p,2,n ďƒŞ ďƒş 2 ďƒŞ ďƒş ď ˛z  r1 (u p 1,3,n 1  u p 1,3,n1 )  (1  2r1  z )u p,3,n1  zu p,3,n  zu p,3,n v p,3,n ďƒŞ ďƒş 2 ď ˛z  r1 (u p 1,4,n1  u p 1, 4,n1 )  (1  2r1  z )u p, 4,n1  zu p,4,n  zu p,4,n v p,4,n ďƒŞ ďƒş ďƒŞ ďƒş 2 ď ˛z  r1 (u p 1,5,n1  u p 1,5,n1 )  (1  2 r1  z )u p,5,n1  zu p,5,n  zu p,5,n v p,5,n ďƒŞ ďƒş . ďƒŞ ďƒş ďƒŞ ďƒş . ďƒŞ ďƒş . ďƒŞ ďƒş . ďƒŞ ďƒş ďƒŞ ďƒş ďƒŞ ďƒş ďƒŞ ďƒş ďƒŞ ďƒş ďƒŞ ď ˛z  r1 (u p 1,M 1,n1  u p 1,M 1,n1 )  (1  2r1  z )u p,M 1,n1  zu pM 1,2,n  zu 2 p,2,n v pM 1,n1 ďƒş ďƒŤ ďƒť

Also for AV=B the tridiagonal is in the form

ďƒŠ(1  2m2 ) ďƒŞ  m2 ďƒŞ 0 ďƒŞ ďƒŞ 0 ďƒŞ . ďƒŞ . ďƒŞ . ďƒŞ ďƒŞ . ďƒŞ . ďƒŞ 0 ďƒŞ ďƒŤ 0

 m2

(1  2m2 )  m2

0

0

0

.

.

.

 m2 (1  2m2 )

0

0

0

0

0

 m2

0

0

0

0

0

 m2

(1  2m2 )  m2  m1 . .

0

0

.

0

0

.

.

.

.

.

0

0

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0

0

0

0

0

0

0

0

0  m2 (1  2m2 ) 0 0  m2

ďƒš 0 ďƒş ďƒş 0 ďƒş ďƒş ďƒş ďƒş ďƒş ďƒş . ďƒş ďƒş .  m2 ďƒş ďƒş (1  2m2 ) ďƒť 0

ďƒŠ v p , 2,n  2 ďƒš ďƒŞ v ďƒş ďƒŞ p ,3,n2 ďƒş ďƒŞ v p , 4,n  2 ďƒş ďƒŞ v p ,5,n2 ďƒş ďƒŞ ďƒş . ďƒŞ ďƒş . ďƒŞ ďƒş= ďƒŞ ďƒş . ďƒŞ ďƒş ďƒŞ ďƒş ďƒŞ v p ,M 3,n2 ďƒş ďƒŞ v p , M  2,n  2 ďƒş ďƒŞv ďƒş ďƒŤ p ,M 1,n2 ďƒť

2 ďƒŠ ďƒš m1 (v p 1, 2,n1  v p 1, 2,n1 )  (1  2 m1  zK )v p ,2,n1  zu p , 2,n  zu p , 2,n v p ,2,n ďƒŞ ďƒş 2 ďƒŞ ďƒş m1 (v p 1,3,n1  v p 1,3,n1 )  (1  2 m1  zK )v p ,3,n1  zu p ,3,n  zu p ,3,n v p ,3,n ďƒŞ ďƒş 2 m1 (v p 1, 4,n1  v p 1, 4,n1 )  (1  2 m1  zK )v p ,4,n1  zu p , 4,n  zu p , 4,n v p ,4,n ďƒŞ ďƒş ďƒŞ ďƒş ďƒŞ ďƒş . ďƒŞ ďƒş . ďƒŞ ďƒş ďƒŞ ďƒş . ďƒŞ ďƒş . ďƒŞ ďƒş ďƒŞ ďƒş ďƒŞ ďƒş ďƒŞ ďƒş ďƒŞ ďƒş 2 ďƒŤďƒŞm1 (v p1,M 1,n1  v p1,M 1,n1 )  (1  2m1  zK )v p,M 1,n1  zu p,M 1,n  zu p,M 1,n v p,M 1,n ďƒťďƒş

2.2. Numerical Stability In Two Dimensional Spaces: 2.3.1 Numerical stability of ADE: The Von-Neumann method has been used to study the stability analysis of Glycolysis model in two dimensions; we can apply this method by substituting the solution in finite difference method at time t by ď š (t )e mď ˘x e mď §y , where ď ˘ , ď §  0 and m   1 . To apply Von-Neumann on the first equation of Glycolysis model ď‚śu ď‚śt ď‚śv ď‚śt

 d1[

2 2 ď‚ś u ď‚ś u 2  ]  u  Kv  u v  ď ˛ , 2 2 ď‚śx ď‚śy

 d2[

2 2  v  v 2  ]  Kv  u v  del, 2 2 x y

For the first equation after linearizing it and for some values of đ?œŒ and K neglect the terms đ?œŒđ?‘§ and zKv p,q,n [3], will be in the form

www.ijeijournal.com

Page | 5

The Finite Difference Methods and Its Stability for Glycolysis Model in Two Dimensions ď š (t  ď „t )e mď ˘x e mď §y  (1  4r1  z )ď š (t )e mď ˘x e mď §y  r1 (ď š (t )e mď ˘ ( xď€Ťď „x) e mď §y  ď š (t )e mď ˘ ( xď€­ď „x) e mď §y  ď š (t )e mď ˘x e mď § ( yď€Ťď „y )  ď š (t )e mď ˘x e mď § ( yď€­ď „y ) .

Now dividing both sides of the above equation by

ď š (t )emď ˘x emď §y

to obtain

ď š (t  ď „t )  (1  4r1  z )  r1 (e mď ˘ď „x  e mď ˘ď „x  e mď ˘ď „y  e mď ˘ď „y ) ď š (t )  (1  4r1  z )  r1 (2 cos( ď ˘ď „x)  2 cos(ď §ď „y )  (1  4r1  z )  r1 (1  2 sin 2 ( ď ˘ď „x / 2)  1  2 sin 2 (ď §ď „y / 2)).

For some values of

ď ˘

and

ď § , sin 2 (ď ˘ď „x / 2)

and

sin 2 (ď §ď „y / 2) are unity [4], so

ď š (t  ď „t )  (1  4r1  z )  2r1 (2) ď š (t )  (1  4r1  z )  4r1  (1  8r1  z )  ď ¸ .

For stable situation, we need | ď ¸ |ď‚Ł 1 , so 1 ď‚Ł (1  8r1  z ) ď‚Ł 1 , Case 1: 1 ď‚Ł (1  8r1  z ) ďƒž r1 ď‚Ł Case 2: (1  8r1  z ) ď‚Ł 1 ďƒž r1 ď‚ł

2z 8

z 8

ďƒž neglect this case because r1 ď‚ł 0.

For the second (Linearized) equation of Glycolysis model which is in the form v p,q,n1  (1  4r2  Kz )v p,q,n  r2 (v p1,q,n  v p1,q,n  v p,q1,n  v p,q1,n ).

Let V p,q,n  ď Ş (t )e mď ˘x e mď §y and substituting it in the above equation to obtain ď Ş (t  ď „t )e

mď ˘ ( xď€Ťď „x) mď §y mď ˘ ( xď€­ď „x ) mď §y mď ˘x mď §y e  (1  4r2  Kz )ď Ş (t )e e  r2 (ď Ş (t )e e  mď ˘x mď § ( y ď€Ťď „y ) mď ˘x mď § ( y ď€­ď „y ) e  ď Ş (t ) e e ) mď ˘x mď §y equation by ď Ş (t )e to obtain e

ď Ş (t ) e

Dividing both sides of the above ď Ş (t  ď „t ) ď Ş (t )

 ď ¸  (1  4r2  Kz )  m2 [e

mď ˘ď „x

e

mď ˘ď „x

e

mď §ď „y

e

mď §ď „y

]

 (1  4m2  Kz )  r2 [ 2 cos(ď ˘ď „x )  2 cos(ď §ď „y )] 2 2  (1  4r2  Kz )  2r2 [1  2 sin ( ď ˘ď „x / 2)  1  2 sin (ď §ď „y / 2)] 2 2  (1  4r2 sin ( ď ˘ď „x / 2)  4r2 sin (ď §ď „y / 2)  Kz  (1  8r2  Kz ).

For some values of ď ˘ and ď § , we can assume that ď Ş (t  ď „t ) ď Ş (t )

 ď ¸  (1  8r2  Kz )

Case 2:

unity [4], so

the equation is stable if ď ¸ ď‚Ł 1 which implies that

| 1  8r2 - Kz |ď‚Ł 1 ďƒž 1  (1  8r2  Kz )  1 ,

Case 1:

2 2 sin ( ď ˘ď „x / 2) and sin (ď §ď „y / 2) are

which are located in two cases

 1  (1  8r2  Kz ) ďƒž 8r2  2  Kz ďƒž r2 

2  Kz

(1  8r2  Kz )  1 ďƒž 8r2 ď‚ł  Kz ďƒž r2 ď‚ł  Kz / 8

So the system is stable under the conditions

r1 ď‚Ł

8

and

.

2z 8

,and

r2 

2  Kz 8

.

2.3.2 Numerical stability of ADI: The ADI finite difference form for the first equation of Glycolysis model is given in the form (1  2r1 )u p,q,n1  r1 (u p1,q,n1  u p1,q,n1 )  r2 (u p,q1,n  u p,q1,n )  2 (1  2r2  z )u p,q,n .  zKv p,q,n  zu p,q,n v p,q,n  ď ˛z

By linearization the term zu 2p,q,n vanishes, and for the same values of K and đ?œŒ the terms zKv p,q,n , Then the equation take the form

www.ijeijournal.com

ď ˛z vanishes.

Page | 6

The Finite Difference Methods and Its Stability for Glycolysis Model in Two Dimensions (1  2r1 )u p,q,n1  r1 (u p1,q,n1  u p1,q,n1 )  r2 (u p,q1,n  u p,q1,n )  (1  2r2  z )u p,q,n .

In order to study the stability of the above equation, after letting u p,q,n   (t )e mx e my , where m  obtain

1 ,

we

m ( xx ) my m ( xx) my mx my e  r1 ( (t  t )(e e e e ) mx m ( y y ) mx m ( yy ) mx my r2 ( (t )(e e e e )  (1  2r1  z ) (t )e e . mx my

(1  2r1 ) (t  t )e

Dividing both sides of the above equation by (1  2r1 ) (t  t )  r1 ( (t  t )(e

e

mx

to get

e

e

mx)

)  r2 ( (t )(e

my

e

my )

 (1  2r1  z ) (t ).

Rearranging, we get  r1 (t  t ))(2 cos(x )  r1 (t )(2 cos(y )  (1  2r2  z ) (t ) 2 2  r1 (t  t )[2(1  2 sin ( x / 2)]  r2 (t )[2(1  2 sin ( y / 2)]  (1  2r1  k (b  1)) (t ).

For some values of  and  , assume that the form

2 sin ( x / 2)

and

2 sin (y / 2) are

unity [4] , so the equation will take

(1  2r1 ) (t  t )  r1 (t  t )(2)  r2 (t )(2)  (1  2r2  z ) (t ) (1  4r1 ) (t  t )  (1  4r1  z ) (t )

 (t  t )  (t )

So

 (t  t )  (t )



1  ( 4r2  z ) 1  4r1



(1  4r2  z ) (1  4r1 )

 .

 1 .

Similarly, for the second equation of the Glycolysis model we assume that v p,q,n   (t )e mx e my , where m

 1 ,the

finite difference form of this equation is (1  2r1 )v p,q,n1  r1 (v p1,q,n1  v p1,q,n1 )  r2 (v p1,q,n1  v p1,q,n1 )  (1  Kz  2r2 )v p,q1,n1

Then

m ( xx ) my m ( xx ) my mx my e  r1 (t  t )(e e e e ) mx m ( yy ) mx m ( y y ) mx my r2 ( (t )(e e e e )  (1  Kz  2r2 ) (t )e e . mx my

(1  2r2 ) (t  t )e

Dividing both sides of the above equation by

e

e

, to get

m ( xx) my m ( xx) my mx my e  r2 ( (t  t )e e   (t  t )e e ) mx m ( yy ) mx my mx m ( y y ) mx my r2 ( (t )e e  2 (t )e e   (t ) e e )   (t ) e e .

(1  2r2 ) (t  t )e

Which implies that (1  2r1 ) (t  t )  r1 (t  t )[2 cos(x )]  r2 (t )[2 cos(y )]  (1  Kz  2r ) (t ) 2 2 2 (1  2r1 ) (t  t )  r1 (t  t )[2(1  2 sin ( x / 2)]  r2 ( 2(1  2 sin (y / 2) (t )  (1  Kz  2r ) (t ).

2

For some values of  and  , we have

2 sin ( x / 2 )

and

2 sin (y / 2)

are unity, so we have

(1  2r1 ) (t  t )  r1 (t  t )(2)  r2 (t )  (1  Kz  2r ) (t ).

2

(1  4r1 ) (t  t )  (1  Kz  4r ) (t ) 2

 (t  t )  (t )



(1  ( 4r2  Kz ) (1  4r1 )

 .

2

Where 1. and  2 . stand for the I-plane and II-plane respectively, each of the above terms is conditionally stable. However the combined two-levels has the form 

ADI

  [ 1 2

(1  ( 4r2  Kz )) (1  ( 4r2  Kz )) ][ ].

(1  4r1 ) (1  4r1 )

www.ijeijournal.com

Page | 7

The Finite Difference Methods and Its Stability for Glycolysis Model in Two Dimensions Thus the above scheme is unconditionally stable, each individual equation is conditionally stable by itself, and combined two-level is completely stable.

III.

APPLICATION (NUMERICAL EXAMPLE)

We solved the following example numerically to illustrate the efficiency of the presented methods, suppose we have the system đ?œ•đ?‘˘ = đ?‘‘1 ∆đ?‘˘ − đ?‘˘ + đ?‘˜đ?‘Ł + đ?‘˘2 đ?‘Ł + đ?œŒ, đ?œ•đ?‘Ą

đ?œ•đ?‘Ł

= đ?‘‘2 ∆đ?‘Ł − đ?‘˜đ?‘Ł − đ?‘˘2 đ?‘Ł + đ?›ż We the initial conditions U(x, 0) = Us + 0.01 sin(ď °x/ L) f or 0 ≤x ≤ L V (x, 0) = Vs – 0.12 sin(ď °x/ L) for 0 ≤x ≤ L U(0, t) = Us , U(L, t) = Us and V (0, t) = Vs, V (L, t) = Vs We will take d1=d2=0.01 , đ?œŒ= 0.09 , đ?›ż=-0.004 , Us=0 , Vs=1 Then the results in more details are shown in following table and figure: đ?œ•đ?‘Ą

1.0003 1.0017 1.0028 1.0036 1.0040 1.0042 1.0042 1.0041 1.0040 1.0038 1.0038 1.0038 1.0040 1.0041 1.0042 1.0042 1.0040 1.0036 1.0028 1.0017 1.0003

1.0000 1.0013 1.0024 1.0032 1.0038 1.0041 1.0043 1.0044 1.0044 1.0044 1.0044 1.0044 1.0044 1.0044 1.0043 1.0041 1.0038 1.0032 1.0024 1.0013 1.0000

IV.

CONCLUSION

We saw that alternating direction implicit is more accurate than alternating direction explicit method 2−đ?‘§ 2−đ??žđ?‘§ for solving Glycolysis model and we found that ADE method is stable under condition đ?‘&#x;1 ≤ , and đ?‘&#x;1 ≤ , 8 8 while ADI is unconditionally stable.

REFERENCES [1].

[2].

[3].

[4].

[5].

[6].

[7].

[8].

[9].

Ames,W.F.(1992);’Numerical Methods for Partial Differential Equations’3rd ed.Academic, Inc. Dynamics of PDE, Vol.4, No.2, 167-196, 2007.

Ellbeck, J.C.(1986)� The Pseude-Spectral Method and Path Following Reaction –Diffusion Bifurcation Studies�SIAM J.Sci.Stat.Comput.,Vol. 7,No.2,Pp.599-610.

Logan,J.D.,(1987),"Applied Mathematics", John Wiley and Sons.

Mathews, J. H. and Fink, K. D., (1999)" numerical methods using Matlab", Prentice- Hall, Inc. Shanthakumar, M.;(1989)�Computer Based Numerical Analysis “Khana Publishers.

Sherratt,J.A.,(1996) �Periodic Waves in Reaction Diffusion Models of Oscillatory Biological Systemd; Forma, 11,61-80 .

Smith, G., D., Numerical Solution of Partial Differential Equations, Finite Difference Methods, 2nd edition, Oxford University Press, (1965).

Temam R., Infinite dimensional Dynamical systems in chanics and physics (Springer-Verlag,berlin,1993), D.Barkley and I.G.Kevrekidis, Chaos 4,453 (1994) Yuncheng You , Global Dynamics of the Brusselator Equations,Dynamics of PDE, Vol.4, No.2 (2007), 167-196.

www.ijeijournal.com

Page | 8