Review Paper on Automated Feature Demodulate of A/V in Retinal Images for Classification

IJSRD - International Journal for Scientific Research & Development| Vol. 4, Issue 04, 2016 | ISSN (online): 2321-0613

Review Paper on Automated Feature Demodulate of A/V in Retinal Images for Classification Mr. Devadatta D. Pukale1 Dr. S. L. Lahudkar2 1 P.G. Student 2Faculty 1,2 Department of Electronic & Tele-Communication Engineering 1,2 JSPM’s ICOER Wagholi, Pune Abstract— The classification of retinal image vessels into artery/vein is an most important phase for automating the detection of vascular changes of retinal, and for the calculation of characteristic allotted with many systemic diseases such as diabetes, hypertension. An automatic approach for A/V classification based on the analysis of a graph extracted from the retinal vasculature images. The system classifies the entire vascular tree image deciding on the type of each intersection point and allotted one of two labels to each vessel segment. Last classification of a vessel segment as A/V is performed through the combination of the graph-based labeling segment results with a set of intensity features.

Key words: Demodulate, A/V I. INTRODUCTION

Fig. 1: Functional Block Diagram of Proposed System Automated detection of retinopathy in eye fundus images using digital image analysis technique has huge potential benefits, allowing checking of a large number of digital images in less time, with lower price and reduced subjectivity than current observer-based techniques. Another advantage is the possibility to perform automated screening for pathological term, such as diabetic retinopathy, in order to reduce the workload required of trained graders. Retinal

vessels are affected by various diseases, namely diabetes, hypertension, and vascular disorders. In diabetic retinopathy, the blood vessels often show abnormalities at early step, as well as vessel diameter alterations. Changes in retinal blood vessels image, such as significant dilatation and elongation of main A/V, and their branches, are also frequently allotted with hypertension and other cardiovascular pathologies.

II. LITERATURE SURVEY In this review, the outline of the principles upon which retinal digital image analysis is base and current techniques is used for automatically detect landmark features of the fundus, such as the optic disc, fovea and blood vessel and the author are use of image for analysis the automated diagnosis of pathology also they review its role in the defining & also performing the quantitative measurements of vascular topography, how these entities are based on ‘optimization’ principles and how they have helped to describe the relationship between systemic cardiovascular disease and retinal vascular changes. We also review the potential future use of fundal image analysis in telemedicine. [1] The author are developed algorithm having for classifying the vessels so by applying y divide impera approach the partitioned of a concentric zone around the OD I.e. optic disc into quadrants. The results find by the advance technique were compared with those provided by a classification on a validation set of 443 vessels and reached an overall classification error of 12 % and which minimizes to 7 % if only the diagnostically important is consider.[9] Diabetic Retinopathy, is a micro vascular often seen in diabetes oriented patients so it is the most common kind cause of visual related loss in working age related population group of produced countries. As our knowledge despite the importance there have only been two approaches to vessel classification yet. Therefore author is advance an improved technique and algorithm compare to feature demodulation technique and two classification technique based on support vector machines & neural networks. Given a hand-segmentation of vessels our approach achieves 95.32% correctly classified vessel pixels. This term minimizes by 10% on average, if the result of a segmentation algorithm is used as basis for the classification. [12] III. PROPOSED SYSTEM A. Advance Concept We concentrate on a characteristic of the retinal vessel tree image that, at least in the region near the optic disc, veins rarely cross veins image and arteries rarely cross arteries image.

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Review Paper on Automated Feature Demodulate of A/V in Retinal Images for Classification (IJSRD/Vol. 4/Issue 04/2016/317)

We define various types of intersection points: bifurcation, traverse, council, and connecting points.

B. Advance Algorithm Auto loading Graph Generation Algorithm.

C. Advance Definition The graph demodulated from the segmented retinal Vasculature is examined to select on the type of intersection graph nodes image, and afterwards one of two labels is allotted to each vessel graph links image.

D. Technique for A/V Classification There are visual and geometrical property that enable favoritism between A/V; various technique have explored these features for A/V categorization. Arteries are bright red image while veins are darker image, and artery calibers are smaller than vein calibers in all images.

E. Graph-Based A/V Classification Technique The technique advance in this paper follows a graph-based approach, where we concentrate on a property of the retinal vessel tree image that, at least in the area near the optic disc, veins rarely cross veins image and arteries rarely cross arteries image. Due to this assumption we define various types of point’s intersection: bifurcation, traverse, council, and connecting points. A bifurcation point is a point of intersection where a vessel bifurcates to narrower parts of image. In a traverse point a A/V cross each other. In a council point the two types of vessels meet each other without crossing point, while a connecting point connects various parts of the same vessel of image. Fig. 1 depicts the block diagram of the advance technique for A/V classification. The main phases are: 1) graph generation; 2) graph analysis; and 3) vessel classification. The technique first demodulate a graph from the vascular tree of image, and after makes a decision on the type of each graph node.

All vessel graph links that belong to a particular vessel image are find and then labeled use two different labels.

Finally, the A/V classes are allotted to the subgraph labels by demodulating a set of property. In the following we detail each phase of the advance technique.

Fig 2: Graph Generation. (A) Original Image; (B) Vessel Segmentation Image; (C) Centerline Image; (D) Adavance Graph

F. Graph Generation A graph is a example of the vascular network, where each node represent an point of intersection in the vascular tree image, and each link corresponds to a vessel segment image between two points of intersection. For making a graph, we have used three-step algorithm of image. First we use the segmented image to find the vessel centerlines, then the graph is find from the centerline image, and finally some additional adjustment are given to the graph 1) Vessel Segmentation 2) Vessel Centerline Demodulation 3) Graph Demodulation 4) Graph Adjustment  Node splitting.  Missing link.  False link

Fig 3: Graph Modifications: (A), (D), (G) Typical Errors; (B), (E), (H) Graph Representation Of The Worst-Case Scenarios; (C), (F), (I) Final Graph Aftermodification.

G. Graph Analysis The output of graph examine phase is a decision on the type of the nodes. In this phase we are not yet able to find whether each label represent to an artery class or to a vein class of image. The A/V classes will be allotted to these sub graphs only in the last classification phase. We have considered four various types of nodes: 1) Connecting point: most of the nodes with two links of an image belong to this type; these nodes, where vessels never cross are repeating nodes connecting various segments of the same vessel of image.

2) Crossing point: two various kind of vessels cross each other.

3) Bifurcation point: a vessel bifurcates the image into narrower vessels image.

4) Meeting point: two various kind of vessels meet each other without crossing; the two vessels are one vessel ends exactly on the other vessel of image. The node classification algorithm starts by demodulating the following node detail: the number of links of image connected to each node degree, the course of each link and the degree of nodes which is adjacent. Node analysis is classify into four various cases depending on the node degree.

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Review Paper on Automated Feature Demodulate of A/V in Retinal Images for Classification (IJSRD/Vol. 4/Issue 04/2016/317)

5) Which are denoted as white dots. Solid lines show the links for one label and the dashed lines denoted the other label.  Nodes of Degree 2  Nodes of Degree 3  Nodes of Degree 4  Nodes of Degree 5 IV. CONCLUSION AND FUTURE PROSPECTS The results of advance A/V family based technique on the images of three various data-bases authenticate that the independence of this technique in A/V of retinal images with various features, such as differences in size & quality of image and also the camera angle. On the other hand, the high accuracy of image achieved by our technique, especially for the largest A/V and confirm that this A/V technique is much reliable for the calculation of various characteristic signs interrelate with vascular alterations.

Further research is planned using the graph that denote the vessel tree image and the A/V technique for AVR calculation and also for finding other vascular signs, such as vascular bifurcation angles, image branching patterns, and fractal-based features of image, which are have a significant effect on the early detection and follow up of some other diseases such as diabetes, hypertension, and cardiovascular diseases.

REFERENCES [1] N. Patton, T. Aslam, T. Mac Gillivray, I. Deary, B. Dhillon, R. Eikelboom, K. Yogesa, and I. J. Constable, “Retinal image analysis: Concepts, applications and potential,” Progr. Retinal Eye Res., vol. 25, p. 99–127, Jan. 2006.

[2] T. T. Nguyen and T. Y. Wong, “Retinal vascular changes and diabetic retinopathy,” Current Diabetes Rep., vol. 9, pp. 277–283, Aug. 2009.

[3] K. Guan, C. Hudson, T. Wong, M. Kisilevsky, R. K. Nrusimhadevara, W. C. Lam, M. Mandelcorn, R. G. Devenyi, and J. G. Flanagan, “Retinal hemodynamics in early diabetic macular edema,” Diabetes, vol. 55, pp.

813–818, Mar. 2006.

[4] C. Sun, J. Wang, D. A. Mackey, and T. Y. Wong, “Retinal vascular caliber: Systemic, environmental, and genetic associations,” Survey Ophthalmol., vol. 54, no.

1, pp. 74–95, 2009.

[5] L. Hubbard, R. J. Brothers, W. N. King, L. X. Clegg, R. Klein, L. S. Cooper, A. Sharrett, M. D. Davis, and J. Cai, “Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the atherosclerosis risk in communities study,” Ophthalmology, vol. 106, pp. 2269–2280, Dec. 1999.

[6] M. Knudtson, K. E. Lee, L. Hubbard, T. Wong, R. Klein, and B. E. K. Klein, “Revised formulas for summarizing retinal vessel diameters,” Current Eye Res., vol. 27, pp. 143–149, Oct. 2003.

[7] M. E. Martinez-Perez, A. D. Hughes, A. V. Stanton, S. A. Thom, N. Chapman, A. A. Bharath, and K. H. Parker, “Retinal vascular tree morphology: A semiautomatic quantification,” IEEE Trans. Biomed. Eng., vol. 49, no. 8, pp. 912–917, Aug. 2002.

[8] K. Rothaus, X. Jiang, and P. Rhiem, “Separation of the retinal vascular graph in arteries and veins based upon structural knowledge,” Image Vis. Comput., vol. 27, pp.

864–875, Jun. 2009.

[9] E. Grisan and A. Ruggeri, “A divide et impera strategy for automatic classification of retinal vessels into arteries and veins,” in Proc. 25th Annu. Int. Conf. IEEE Eng. Med. Biol. Soc., Sep. 2003, pp. 890–893.

[10] S. Vazquez, B. Cancela, N. Barreira, M. Penedo, and M. Saez, “On the automatic computation of the arteriovenous ratio in retinal images: Using minimal paths for the artery/vein classification,” in Proc. Int. Conf. Digital Image Comput., Tech. Appl., 2010, pp. 599–604.

[11] H. Li, W. Hsu, M. Lee, and H. Wang, “A piecewise Gaussian model for profiling and differentiating retinal vessels,” in Proc. Int. Conf. Image Process., vol. 1. Sep. 2003, pp. 1069–1072.

[12] C. Kondermann, D. Kondermann, and M. Yan, “Blood vessel classification into arteries and veins in retinal images,” Proc. SPIE, Progr. Biomed. Opt. Imag., vol.

6512, no. 651247, Feb. 2007.

[13] M. Niemeijer, B. van Ginneken, and M. D. Abramoff, “Automatic classification of retinal vessels into arteries and veins,” Proc. SPIE, Progr. Biomed. Opt. Imag., vol.

7260, no. 72601F, Feb. 2009.

[14] R. Estrada, C. Tomasi, M. T. Cabrera, D. K. Wallace, S. F. Freedman, and S. Farsiu, “Exploratory dijkstra forest based automatic vessel segmentation: Applications in video indirect ophthalmoscopy (VIO),” Biomed. Opt. Exp., vol. 3, no. 2, pp. 327–339, 2012.

[15] K. Deng, J. Tian, J. Zheng, X. Zhang, X. Dai, and M. Xu, “Retinal fundus image registration via vascular structure graph matching,” Int. J. Biomed. Imag., vol.

2010, no. 906067, Jul. 2010.

[16] R. S. Snell and M. A. Lemp, Clinical Anatomy of the Eye. New York, NY, USA: Wiley, 1998.

[17] M. Niemeijer, X. Xu, A. Dumitrescu, P. Gupta, M. A. B. van Ginneken, and J. Folk, “Automated measurement of the arteriolar-to-venular width ratio in digital color fundus photographs,” IEEE Trans. Med. Imag., vol. 30, no. 1, pp. 1941–1950, Nov. 2011.

[18] Mendonça and A. Campilho, “Segmentation of retinal blood vessels by combining the detection of centerlines and morphological reconstruction,” IEEE Trans. Med. Imag., vol. 25, no. 9, pp. 1200–1213, Sep. 2006.

[19] Mendonça, B. Dashtbozorg, and A. Campilho, “Segmentation of the vascular network of the retina,” in Image Analysis and Modeling in Opthalmology, E. Y. K. Ng, U. R. Acharya, J. S. Suri, and A. Campilho, Eds. Boca Raton, FL, USA: CRC Press, 2013.

[20] Z. Guo and R. W. Hall, “Parallel thinning with twosubiteration algorithms,” Commun. ACM, vol. 2, no. 3, pp. 359–373, 1989.

[21] Mendonça, F. Cardoso, A. Sousa, and A. Campilho, “Automatic localization of the optic disc in retinal images based on the entropy of vascular directions,” in Image Analysis and Recognition (Lecture Notes in Computer Science), vol. 7325. New York, NY, USA: Springer-Verlag, 2012, pp. 424–431.

[22] M. Foracchia, E. Grisan, and A. Ruggeri, “Luminosity and contrast normalization in retinal images,” Med. Image Anal., vol. 9, no. 3, pp. 179–190, 2005.

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[23] M. Niemeijer, J. Staal, B. Ginneken, M. Loog, and M. Abramoff. (2004). DRIVE: Digital Retinal Images for Vessel Extraction [Online].

Available: http://www.isi.uu.nl/Research/Databases/DRIVE [24] M. Niemeijer, X. Xu, A. Dumitrescu, P. Gupta, B. van Ginneken, J. Folk, and M. Abramoff. (2011). INSPIREAVR: Iowa Normative Set for Processing Images of the REtina-Artery Vein Ratio [Online]. Available: http://webeye.ophth.uiowa.edu/component/k2/item/270 [25] (2010). VICAVR: VARPA Images for the Computation of the Arterio/Venular Ratio [Online]. Available: http://www.varpa.es/vicavr.html.

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