INDIAN DENTAL ACADEMY •
Leader in continuing dental education
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Am I not destroying my enemies when I make friends of them..? - Abraham Lincoln
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Non Genetic:
Genetic Disorders
Developmental defects – Malformations Chromosomal Gene - Mendelian
Multifactorial
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Genome: whole set – Polyploidy 4n, 8n etc. Chromosomal: change in chromosome.
Number: Trisomy, monosomy Structure: Deletion, Translocation etc.
Gene: Submicroscopic.
Point mutation – single base sequence Deletions Insertions
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Reduction Division (4n-2n) Prophase-1(Synapsis, g.rec) Metaphase-1 Anaphase-1 Telophase-1
Equatorial Division (2n-n) Prophase-2 Metaphase-2 Anaphase-2 Telophase-2
Abnormal number of chromosomes:
Non-disjunction - Down’s Syndrome Anaphase lag - Turner’s xxx
Abnormal Structure: (normal no)
Deletion of short arm 5q- Cri-du-chat syndrome Inversion Translocation - Ph Chromosome - t(9:22) CML,
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Simian Crease •www.indiandentalacademy.com
Mental retardation Neck folds Epicanthic folds Flat facial profile Simian crease Hypotonia Umbilical hernia Leukemia
Briefly describe congenital disorders? What are mendelian disorders? Examples. What is mutation? Classification? Autosomal Dominant & Recessive disorders? What is a karyotype? Uses What is point mutation? Examples? Polyploidy, aneuploidy, haploidy, diploid?
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www.indiandentalacademy.com • Leader in continuing dental education •
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