GROWTH AND DEVELOPMENT OF MAXILLA AND THE MAXILLARY SINUS. www.indiandentalacademy.com
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•INTRODUCTION •DEFINITIONS •FACTORS AFFECTING GROWTH •GROWTH:CONCEPTS,METHODS OF GATHERING DATA AND STUDYING GROWTH •BONE DEVELOPMENT AND GROWTH •THEORIES OF GROWTH •PRENATAL GROWTH AND DEVELOPMENT OF MAXILLA •POST NATAL GROWTH AND DEVELOPMENT OF MAXILLA •DEVELOPMENT OF THE PALATE
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DEFINITIONS OF GROWTH
• J.S.Huxely: The self multiplication of living substance. • Krogman:Increase in size, change in proportion and progressive complexity. • Todd:An increase in size. • Meridith:Entire series of sequential anatomic and phisiologic changes taking place from beginning of prenatal life to senility. • Moyers:Quantitative aspect of biologic development per unit time. • Moss: Change in any morphological parameter which is measurable. www.indiandentalacademy.com
DEFINITIONS OF DEVELOPEMENT • Todd:Development is progress towards maturity. • Moyers: Development refers to all the naturally occuring unidirectional changes in the life of an individual from its existence as a single cell to its elobaration as a multifunctional unit terminating in death. Thus it encompasses the normal sequential events between fertilization and death.
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FACTORS AFFECTING PHYSICAL GROWTH • • • • • • • • • • •
Heredity Nutrition Illness Race Race Socioeconomic factors Family size and birth order Secular trends Climatic and seasonal effects Psychological disturbances www.indiandentalacademy.com Exercise
SOME CONCEPTS OF GROWTH • Pattern • Scammon’s Growth Curve
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SCAMMON’S GROWTH CURVE
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METHODS OF GATHERING GROWTH DATA • Longitudinal studies • Cross sectional studies • Semi longitudinal studies www.indiandentalacademy.com
TYPES OF GROWTH DATA • Opinion • Observations • Ratings and rankings
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METHODS OF STUDYING GROWTH • Measurement approaches • Craniometry • Anthropometry • Cephalometric radiology
• Experimental approaches Vital staining Radioisotopes Implants Radiographic techniques Natural markers Comparative anatomy www.indiandentalacademy.com
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BONE DEVELOPMENT AND GROWTH
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THEORIES OF GROWTH AND DEVELOPMENT • • • • • • •
Genetic theory Sutural theory Cartilagenous theory Functional matrix theory Van Limborgh’s theory Enlow’s expanding “V” principle Enlow’s Counterpart principle www.indiandentalacademy.com
PRENATAL DEVELOPMENT OF THE MAXILLA The prenatal life may be divided into three periods : The period of the ovum [fertilization to the end of fourteenth day] The period of the embryo [14th to 56th day ] The period of the foetus [56th to Birth ] THE PERIOD OF OVUM: This period consists primarily of cleavage of the ovum and attachment to the uterine wall . At the end of this period the ovum is only 1.5 mm in length and cephalad differention has not yet begun. www.indiandentalacademy.com
THE PERIOD OF THE EMBRYO: This period is charecterised by the following events: Formation of the three germ layers Formation of the pharyngeal arches Differentiation of the mesenchyme to signal beginning of endochondral and intramembranous bone formation
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FORMATION OF THE THREE GERM LAYERS The blastocyst [day 5 ] has cells arranged in two layers : 1.The outer cell mass which will form the trophoblast 2.The inner cell mass which will give rise to the embryo proper “embryoblast”
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IMPLANTATION TAKES PLACE AT THE END OF 1ST WEEK
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--At the 8th day of development the trophoblast has differenti ated into two layers: Inner layer: Cytotrophoblast Outer layer:Syncytiotrophoblast The cells of embryoblast also differentiate into two layers: ---A layer of small cuboidal cells : hypoblast ---A layer of high columnar cells : epiblast The hypoblast and the epiblast together constitute the bilaminar germ disc www.indiandentalacademy.com
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--A small cavity is formed within the epiblast . This is called the AMNIOTIC CAVITY --Around the 13th day of development the following structures are seen: Secondary yolk sac Extraembryonic coelom [ Chorionic cavity ] Connecting stalk [ Future embryonic stalk ] Prochordal plate [ Where the epiblast cells are firmly attached to the hypoblast cells ……The future Buccopharyngeal membrane ] www.indiandentalacademy.com
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During the 3rd week there is appearance of the “primitive streak” with the “ primitive node” In the region of the node and the streak, the epiblast cells invaginate a new cell layer between the hypoblast [ now called the ENDODERM ] and the epiblast [now called the ECTODERM] This third layer is called the MESODERM The process of mesoderm formation is called the GASTRULATION These cells form a tube like process called the NOTOCHORDAL PROCESS which gets filled in by cells to form the NOTOCHORD www.indiandentalacademy.com
Notochord forms the midline axis which serves as the basis for axial skeleton . It extends from the prochordal plate in the cephalic region to the cloacal membrane in the region caudal to the primitive streak .
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ECTODERM
MESODERM
ENDODERM
Central Nervous System
Myotome {muscle}
Epithelial lining for GIT, Respiratory tract and Bladder.
Peripheral Nervous System
Sclerotome {Cartilage and Bone}
Parenchyma of tonsil, thyroid,parathyroid,thymus ,liver and pancreas.
Sensory Epithelium of the Ear, Nose and Eye
Dermatome {Subcutaneous tissue of skin}
Epithelial lining of tympanic cavity and Eustachian tube
Skin, Hair, Nails
Vascular System
Pituitary, Mammary and Sweat Glands
Uro-genital System {excluding the bladder}
Enamel of the Tooth
Spleen and Supra Renal glands www.indiandentalacademy.com
THE NEURAL CREST CELLS They give rise to 1. Sensory ganglia 2. Schawnn cells 3. Pigment cells 4. Odontoblasts 5. Meninges 6. Cartilage cells of branchial arches They have a possible important function in the formation of face www.indiandentalacademy.com
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When the embryo is 41/2 weeks old five mesenchymal swellings can be recognized: The Mandibular Swellings [ 1st Pharyngeal Arch ] The Maxillary Swellings [ Dorsal portion of 1st Arch] The Frontal Prominence Each Pharyngeal Arch is thus characterized by its own : Muscular Component Cranial Nerve Component Arterial component www.indiandentalacademy.com
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The mesenchyme of the maxillary process subsequently gives rise to the following: Premaxilla Maxilla Zygomatic bone Temporal bone in part All these bones undergo intramembranous ossification.
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BRANCHIAL AND PHARYNGEAL ANOMOLIES CONGENITAL AURICULAR SINUS AND CYSTS: They are found in a triangular area of skin anterior to ear. They are remnants of the 1st branchial groove. BRANCHIAL SINUSES: Open on the side of the neck and result from the failure of the 2nd branchial groove to close. The blind pit or sinus that remains opens along the anterior border of the sternocleidomastoid. www.indiandentalacademy.com
FORMATION OF THE PHARYNGEAL ARCHES The most typical feature in the development of the head and neck is formed by the BRANCHIAL or the PHARYNGEAL ARCHES They appear in the 4th and 5th week of development and contribute greately to the characteristic appearance of the embryo. With this a number of outpocketings the PHARYNGEAL POUCHES appear along the lateral walls of the pharyngeal gut-the most cranial part of the foregut. At the end of 4th week the centre of the face is formed STOMODEUM ,surrounded by the first pair of pharyngeal www.indiandentalacademy.com arches .
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When the embryo is 4 ½ weeks old, five mesenchymal swellings can be seen: Two Mandibular Swellings [1st Pharyngeal Arch ] Two Maxillary Swellings[Dorsal Portion of the 1st Arch] The Frontal Prominence
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BRANCHIAL FISTULA: It is a communication between the intratonsillar cleft and the side of the neck- persistence of the 2nd branchial groove and the 2nd pharyngeal pouch. BRANCHIAL CYST: Remnants of part of cervical sinus and/or the 2nd branchial groove may persist and form this cyst ‌..it is located along the anterior border of the sternocleidomastoid. FIRST ARCH SYNDROME: Due to insufficient migration of the neural crest cells into the 1st arch. Some of the more common are: www.indiandentalacademy.com
TREACHER COLLINS SYNDROME: Malar hypoplasia Antimongoloid palpebral fissures Defects of lower eyelids Deformed external ears Abnormalities of middle and internal ears PIEERE ROBIN SYNDROME: Hypoplasia of mandible Cleft palate Defects of the eye and the ear
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DI GEORGE SYNDROME: Hypoparathyroidism Increased susceptibility to infections Fish mouth deformity Low set notched ears Thyroid hypoplasia Cardiac abnormalities
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CONTROL PROCESSES AND FACTORS IN FACIAL GROWTH VAN LIMBORGH’S CLASSIFICATION Intrinsic genetic factors:Inherent in skeletal tissues themselves.They exert influence inside the cell to which they are inherent. Local Epigenetic factors:Epigenesis includes the sum total of all biochemical and biophysical events produced by the functioning of the cells and organs ……Petrovic General Epigenetic factors Local environmental factors www.indiandentalacademy.com General environmental factors
E P IG E N E T IC F A C T O R S LO CAL G e n e t i c c o n t r o l o ri g i n a t i n g f r o m a d j a ce n t st r u ct u re a n d p ro vi d e l o c a l a ct i o n s E xa m p l e : E m b ryo n i c i n d u ct i o n i n f l u e n ce s s k. g ro w t h B ra i n , e ye
GENERAL G e n e t i c co n t r o l o ri g i n a t i n g f r o m d i s t a n t st r u ct u re a n d p ro vi d e g e n e ra l a ct i o n s E xa m p l e : H o rm o n e s
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E N V IR O N M E N T A L F A C T O R S
LO CAL
GENERAL
N o n g e n e t ic in flu e n c e e v o k e d b y s t im u li o r ig in a t in g fr o m e x t e r n a l e n v ir o n m e n t E x a m p le : h a b it s , fo r c e s o f m u s c . c o n t r a c t io n
T h e s e a r e G e n e r a l n o n g e n e t ic in flu e n c e s E x a m p le : N u t r it io n , fo o d , o x y g e n .
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THE CONTROL PROCESSES THE GENETIC BLUE PRINT: Genes have a fundamental and perhaps an overriding influence in establishing basic facial pattern but they are NOT exclusive determinants of all growth parameters. BIOCHEMICAL FORCES: The play of physical forces acting on a bone to regulate its development, morphologic configuration, histological structure and physical properties. www.indiandentalacademy.com
WOLFF’S LAW: The architecture of bone is such that it can best resist the forces that are brought to bear upon it with the use of as little tissue as possible. It has a flaw in that the law doesn’t distinguish between physical forces acting on a bone and forces acting on the osteogenic connective tissue that actually produce any remodelling of the bone. SUTURES,CONDYLES AND SYNCHONDROSES: Growth,form and dimensions of a bone are governed by intrinsic genetic programming residing within that bone’s own bone –producing cells of periosteum,sutures and bone related cartilages –provide inclusive growth regulation for each of the whole bones they serve. Modern research discounts such a concept . www.indiandentalacademy.com
CONTROL MESSENGERS: Growth control is essentially a localised developmental process working with local function as it responds to multiple developmental interplay with other growing parts. FORCE/PRESSURE/TENSION BIOPHYSICAL REACTIONS-Bone deformation,compression of periodontal ligament,tissue injury
PRODUCTION OF FIRST MESSENGERS Hormones[PTH],Prostaglandins,Neurotransmitters
PRODUCTION OF 2nd MESSENGERS[Camp,Cgmp,Ca] www.indiandentalacademy.com INCREASE IN CELLS OF RESORPTION/DEPOSITION
POSTNATAL GROWTH AND DEVELOPMENT OF MAXILLA The growth of maxilla depends on influence of several functional matrices that act upon different areas of the bone thus allowing its subdivision into skeletal units: The BASAL BODY beneath the INFRAORBITAL NERVE, later surrounding it to form the infraorbital canal. The ORBITAL UNIT responds to the growth of the eyeball www.indiandentalacademy.com
The NASAL UNIT depends on the SEPTAL CARTILAGE for its growth. The TEETH provide the functional matrix for the ALVEOLAR UNIT The PNEUMATIC UNIT reflects maxillary sinus expansion,which is more a responder than a determiner of the skeletal unit.
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THE 3 PRINCIPLE REGIONS OF FACIAL AND NEUROCRANIAL DEVELOPMENT THE BRAIN AND THE BASICRANIUM: The above said determines the persons headform and type Ex:A long and narrow basicranium gives rise to dolicocephalic facial form while a brachycephalic facial form gives a wider facial configuration BASICRANIUM is the template that establishes the shape and perimeter of the facial growth field. THE AIRWAY: The configuration and www.indiandentalacademy.com dimensions of the airway are a product
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of the composite growth of many hard and soft tissues along its pathway from nares to glottis. These parts are again dependent upon the airway for maintanance of their own functional and anatomic position. It functions as a key stone for the face. THE ORAL REGION: Compensatory adjustments by the remodelling process occur throughout growth and development in many ways. The oral region is one of the areas around which these changes take place.
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A CORNERSTONE OF GROWTH PROCESS Remodelling Displacement REMODELLING: Refers to a process where bone deposition and resorption occur so as to bring about change in size , shape and relationship of the bone . FUNCTIONS OF REMODELLING: www.indiandentalacademy.com Progressively create the changing size of bone
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Sequentially relocate each of the component regions of the whole bone to allow for overall enlargement. Shape the bone to accommodate its various functions Provide fine tune fitting of all the separate bones to each other and to their contiguous soft tissues. DISPLACEMENT: It is the physical movement of the whole bone and occurs while the bone simultaneously remodels by resorption and deposition. Bone deposition doesn’t push the articular contact surface of another bone and provide growth….rather bone is carried by the expansive force of all growing soft tissues around it and attached to it by anchoring fibres. www.indiandentalacademy.com
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DISPLACEMENT : THE GREAT CONTROVERSY
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PRIMARY DISPLACEMENT: Movement of a bone because of its own growth . SECONDARY DISPLACEMENT: Movement of a bone passively or secondary to growth of contiguous bone/s. DRIFT: The combination of bone deposition and resorption resulting in a growth movement towards the depositing surface is called drift. RELOCATION: The progressive sequential movement of component parts as a bone enlarges is relocation. www.indiandentalacademy.com
THE MAXILLARY TUBEROSITY AND ARCH LENGETHINING: The horizontal lengethening of maxilla is produced by remodelling at the maxillary tuberosity Back facing periosteum of tuberosity has continuous deposits of new bone as long as srowth in this part continues. The lateral surface is also depositiory …the arch widens. The endosteal side of the cortex is resorptive …the maxillary sinus expands as a result. The whole maxilla undergoes primary displacement in an anterior and inferior direction as it grows. www.indiandentalacademy.com
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THE GROWTH AND DEVELOPMENT OF THE NASOMAXILLARY COMPLEX The maxillary tuberosity and arch lengethening The lacrimal suture-a key growth mediator. The maxillary tuberosity and the key ridge The vertical drift of teeth The nasal airway Palatal remodelling Downward maxillary displacement The cheekbone and the zygomatic arch Orbital growth www.indiandentalacademy.com
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THE LACRIMAL SUTURE A KEY GROWTH MEDIATOR The lacrimal bone is a diminutive flake of a bony island which is surrounded by sutural connective tissue. The sutural system of the lacrimal bone provides for the slippage of multiple bones along sutural interfaces with the pivotal lacrimal as they all enlarge differentially. The lacrimal sutures allow maxilla to slide downward along its orbital contacts which facilitates inferior displacement of the maxilla. THE MAXILLARY TUBEROSITY AND THE KEY RIDGE: Major change occurs in surface contour along the vertical crest below malar protruberance called the key ridge. A reversal occurs here where by external surface of maxillary arch anterior to it is resorptive. www.indiandentalacademy.com Similarly reversal is seen at Point A as well.
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THE VERTICAL DRIFT OF TEETH: AN IMPORTANT CLINICAL CONSIDERATION The term vertical drift denotes the displacement of the whole tooth along with its alveolar housing in an occlusal direction. As the jaws grow the dentition drifts both vertically and horizontally to keep phase in the respective anatomic positions. THE NASAL AIRWAY The lining surfaces of the bony walls and floor of the nasal chambers are resorptive accept for the nasal side of the olfactory fossae. This produces a lateral and anteiror expansion of the www.indiandentalacademy.com nasal chamber and a downward relocation of the palate.
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ďƒ˜ The breadth of the nasal bridge in the region just below the frontonasal sutures does not markedly increase from childhood to adult hood. More inferiorly in the inter orbital area the medial wall of each orbit expands and balloons out considerably in a lateral direction.
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PALATAL REMODELING Even though the labial side of the whole anterior part of the maxillary arch is resorptive, the arch none the less increases in width and the palate becomes wider (the ‘V’ principle). DOWNWARD MAXILLARY DISPLACEMENT The primary displacement of the whole ethmomaxillary complex in a downward direction is accompanied by simultaneous remodeling in all areas. www.indiandentalacademy.com
ďƒ˜New bone added at the following sutures -Frontomaxillary -Zygotemporal -Zygosphenoidal -Zygomaxillary -Ethmomaxillary -Ethmofrontal -Nasomaxillary -Nasofrontal -Frontolacrimal -Palatine -Vomerine www.indiandentalacademy.com
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THE CHEEK BONE AND ZYGOMATIC ARCH ďƒ˜ The posterior side of malar protuberance within the temporal fossae is deposited in while the anterior surface is resorptive. Thus the cheek bone relocate posteriorly as it enlarges. ďƒ˜ This results in a protrusive appearing nose and an anteroposteriorly much deeper face.
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ORBITAL GROWTH The remodeling changes in orbit are complex as it comprises of a number of bones including 1. Maxilla 2. Ethmoid 3. Lacrymal 4. Frontal 5. Zygomatic 6. Greater and lesser wings of sphenoid There is bone deposition along much of the walls of the orbit except the lateral wall which is resorptive. The orbit also grows by ‘V’ principle, so that the cone shaped orbital cavity moves in a direction towards its wide opening. In the child the floor of nasal and orbital cavities are at about the samewww.indiandentalacademy.com level. But in the adult the nasal
SEX DIFFERENCES ďƒ˜ The females have 1. More upright and bulbous forehead 2. Lesser eyebrow ridges 3. Small and less protrusive nose 4. Lower nasal bridge 5. A more rounded nasal tip 6. Flatter face 7. Wider appearing face with more prominent appearing cheek bones. www.indiandentalacademy.com
DEVELOPMENT OF PALATE The palate is formed from three components a) The two palatal process b) The primitive palate formed from frontonasal process. The definitive palate is found by the fusion of these three parts The transition from vertical to horizontal position is completed within hours. Some of the mechanisms are - Biochemical transformation in the physical consistency of the connective tissue matrix of the shelves. - Variation in vasculature and blood flow to this structures www.indiandentalacademy.com
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The sudden increase in tissue turgor
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Intrinsic shelf force
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Muscular movements
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ANAMOLIES OF PALATAL DEVELOPMENT Epstein’s pearls and Bohn’s nodules The entrapment of epithelial rests or pearls in the line of fusion of the palatal shelves may give rise to median palatal rests cysts. II. Dental lamina cysts Epithelial remnants of dental lamina that develop on the crest of alveolar ridge.
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III. Torus palatinus: IV. Oblique facial cleft Failure of maxillary swelling to merge with its corresponding lateral nasal swelling results in this deformity. V. Cleft lip and Palate Successful fusion of the three embryonic components of the palate involves complicated synchronization of 1. Shelf movements with growth 2. Withdrawal of the tongue 3. Growth of the mandible and head www.indiandentalacademy.com
CLASSIFICATION OF CLEFT LIP AND PALATE Davis and Ritchi (1922) and Veau (1931) have given the following classification Class I – Cleft of soft palate only Class II – Cleft of hard and soft palate till the incisive foramen Class III – Complete unilateral cleft of the soft palate, hard palate, the alveolar ridge and the lip on one side. Class IV – Complete cleft of soft palate, hard palate, alveolar ridge and the lip on both sides. www.indiandentalacademy.com
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INCIDENCE Cleft lip : 1:1000 Births, More in males Cleft palate : 1:2500 Births, More in females PROSTHODONTIC TREATMENT If it is decided the surgery will be unsuccessful for the treatment of cleft soft palate then the first obturator is given at 2 years There are three types: 1. Fixed pharyngeal 2. Hinged pharyngeal 3. Meatal The cleft of hard palate can be so easily covered by www.indiandentalacademy.com means of a simple acrylic or metallic palate.
PHARYNGE AL ARCH
NERVE
MUSCLES
SKELETON
Mandibular
V-Mandibular div.
Muscles of mastication, Ant. Belly of Digastric,Tensor Palatini,Tensor Tympani.
Incus,Malleus, Ant. Ligament of Malleus,Sphenomandibular ligament ,Portion of mandible.
Hyoid
VII-Facial
Muscles of facial expression, Post. Belly of Digastric, Stylohyoid,Stapedius.
Stapes,Styloid process,Stylohyoid Ligament, Smaller horn and Superior body of Hyoid.
III
IX-Glossopharyngeal
Stylopharyngeus
Greater horn, Lower part of Body of Hyoid.
IV-VI
Sup.Laryngeal, Rec.Laryngeal.
Muscles of Pharynx, Soft Palate and Larynx.
Laryngeal Cartilages.
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ENDODERMAL POUCH
DERIVATIVES
I
Tubo tympanic recess-Auditory tube,middle ear cavity,tympanic antrum.
II
Tonsil.
III
Inferior Parathyroids,Thymus.
IV
Sup.parathyroids.
V
Ultimo Branchial bodyParafollicular cells of thyroid.
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TIMING OF PRIMARY CLEFT LIP AND PALATE PROCEDURES. {After Delaire}
CLEFT LIP ALONE
UNILATERAL ↓ One operation at 5-6 months.
BILATERAL ↓ One operation at 5-6 months.
CLEFT PALATE ALONE
SOFT PALATE ALONE ↓ One operation at 5-6 months.
SOFT + HARD PALATE ↓
Two operations ↓ Soft palate –6 months ↓ Hard palate- 12- 15 months
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CLEFT LIP AND PALATE UNILATERAL
↓ Two operations ↓ Cleft lip + soft palate – 5-6 months ↓ Hard palate + gum pad +/- lip revision – 12-15 months
BILATERAL
↓ Two operations ↓ Cleft lip + soft palate – 5-6months ↓ Hard palate + gum pad +/- lip revision – 12-15 months
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