develops

AI-based tool to probe gut bacteria

enzymes to process what a human eats and provide the body with various metabolites that are essential for health and body functions.

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Bhopal, March 30 (IANS)

Researchers at the Indian Institute of Science Education and Research (IISER) Bhopal have developed an Artificial Intelligence (AI) based method to predict how the bacteria in the gut break down the various types of food and medication, the institute said on Thursday.

This AI-based tool called "GutBug" provides information about the specific bacterial enzymes, reactions, and bacteria involved in the process of digestion and absorption of nutrients by the human gut.

The human gut microbiome is made of over a thousand different species of bacteria, which have more than 3.3 million unique genes. These bacteria secrete

However, studying the complex host-microbial relationships is a challenge because of the vastness of the microbiome and the fact that the collection of bacteria varies among individuals.

But the tool GutBug, detailed in the Journal of Molecular Biology, can potentially predict all possible bacterial enzymes that act on bioactive dietary molecules as well as oral drugs, the researchers said.

"GutBug uses a combination of machine learning, neural networks, and chemoinformatic methods. We used a curated database of 363,872 enzymes from about 700 human gut bacterial strains and a substrate database consisting of 3,457 enzymes to train the AI model," said Dr Vineet K. Sharma, IISER Bhopal, in a statement.

"GutBug can help us better understand how the food we eat or medicines we consume orally are processed by our gut bacteria and how this affects our health. Such understanding can be useful in designing diets, developing new prebiotics, creating nutraceutical products, and improving drug design depending on the nature of the gut bacteria each individual has, leading to personalised medicine," Sharma said.

To train the AI model the study used the largest enzyme substrate database. It contained information on the gut bacterial species from eight populations to understand how drug and food metabolism varies across populations due to gut bacteria activity.

GutBug was able to identify the specific enzymes involved in the breakdown of various molecules and the bacterial strains that carry them.

The tool was tested with 27 different molecules, including complex carbohydrates, flavonoids, and drugs, and was shown to be highly accurate, with success rates ranging from 0.78 to 0.97.

Assam govt to set up a separate board to recruit college teachers

forced the government to take this decision.

"We have now decided to forego any further academics-based hiring by colleges. This approach causes a lot of legal disputes," he said.

Replying to a question raised by AIUDF MLA Ashraful Hussain, Pegu said, "The education department has been facing at least 2,500 court cases related to the recruitment of teachers in schools and colleges."

Guwahati, March 30 (IANS) The Assam government informed the Assembly on Thursday that a central hiring board will be established to recruit teachers in colleges across the state. Accordingly, college authorities have been asked not to initiate any new hiring process on their own.

State Education Minister Ranoj Pegu said a large number of pending court cases related to the recruitment of teachers has

The minister said a total of 640 teaching posts in colleges are lying vacant across the state.

"We have chosen to build a centralized recruitment board. After passing the selection test, a candidate will be posted to the college of his/her choice," Pegu added.

However, the colleges which have already initiated the recruitment process have been allowed to complete it.