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‘HIV cure soon’
‘The cloning of the antibodies enabled the researchers to make large quantities for further testing’ Johannesburg - Sustained research programmes will eventually lead scientists to develop a vaccine for prevention and treatment of HIV/Aids, Health Minister Aaron Motsoaledi has said. That was after the announcement of the discovery of a method to develop antibodies able to kill multiple strains of HIV. “I think we are a step closer to a viable vaccine. These studies illustrate the importance of research and need for patience and dedication. In 2009, we were worried that research and development were taking a knock, but now every year something is announced by our scientists,” he said. National Institute of Communicable Diseases virology head Prof Lynn Morris said the antibodies capable of combating HIV would be sent for pre-clinical tests. She said a small number of HIV-infected people naturally developed these antibodies, but were not helped by them because they were unable to kill the wide range of HIV. “We need to understand how to make better antibodies to HIV. We can learn that from people who are already infected, because some of them make these broadly neutralising antibodies. We hope that will help make a better HIV vaccine.” A KZN woman, identified in the research as CAP256, responded to
HIV by making the antibodies. The research team identified the antibodies in her blood, cloned them in a laboratory, then used them to find the pathway followed by her immune system to make them. The identification and cloning of the antibodies enabled the researchers to make large quantities for further testing, similar to the way a medicine used to prevent or treat HIV/Aids would be tested. “What we have to Health Minister Dr Aaron Motsoaledi do now is to design a vaccine that is able of pre-clinical trials in monkeys, a to engage with the rare B-cells. If process which could take years to we are able to do that, we should prove their efficacy. If successful, be able to make a vaccine that will the research would guide HIV vactake months for people to develop cine development. The antibodies the immunity against HIV/Aids,” might also be used to treat HIV. said Morris. Science and Technology Minister Antibodies are specialised cells Derek Hanekom said the project produced by B-cells as a primary could make significant strides in immune defence for the body. the global quest for an HIV vacThey are used by the body for cine. “The knowledge that has either treatment or prevention. been generated could make an Morris said CAP256’s antibod- enormous difference in the search ies would be used in a sequence for an effective vaccine,” he said.