MESTASTOP SOLUTIONS

TO WATCH IN 2022

CREATING A DIFFERENCE BY UNDERSTANDING METASTASIS BIOLOGY AND ADDRESSING MUCH NEEDED DISCOVERY AND DIAGNOSTIC EFFORTS

Puja Bhardwaj | Business Connect

The most painful experience in cancer is not the death, but the anticipation of death, that both the patient and their loved ones go through. This is because cancer can spread or metastasise anytime, even after the best of surgery or chemotherapy, and life comes down to living between PET scans and Blood tests.

With the vision to stop this suffering by filling the gaps in the understanding of metastasis biology and targeting it the right way in clinical settings, an incredible venture, Mestastop Solutions came into existence in 2018. The startup has a two – pronged approach, to both identify this phenomenon early (diagnostics) and intervene with this process (discovery). Mestastop is focused on the spreading of cancer cells from one part of the body to the others, a process known as metastasis. Mestastop Solutions has been at the forefront of IP generation, creating unique proprietary platforms to help solve the problem of cancer metastasis by facilitating drug discovery and early predictive diagnosis.

WHAT’S UNIQUE ABOUT MESTASTOP? All previous approaches to interfere with metastasis were focused on the initial steps of cells moving out of the tumor and always targeted the growing cells. Paradoxically, the moving and growing tumor cells are very different, and the concept of Mestastop is focused on the moving cells only, as they are the most relevant for metastasis. Also, the team has identified critical rate-limiting steps of metastasis that were neglected before and have validated both these new concepts in patient samples, which minimizes the chances of clinical failures.

WORK CULTURE – THE MAIN STRENGTH BEHIND MESTASTOP The whole team at Mestastop works 8 – 9 hours a day, but they work together, i.e., they back each other, and it is always a collective success or a collective failure. Trust and belief in each other work wonders for them.

Mestastop follows an open culture policy where a team of self-motivated people is working selflessly to make a difference. Here, everyone is a thought leader or is being groomed as a potential leader, and all are bound by a thread of passion and motivation; to change the central dogma around cancer treatment. The leading team focuses on just picking the people with the right mindset. Rest, everyone is on autopilot!

MESTASTOP’S IN FIVE WORDS Intent – Courage – Diligence – Resilience – Integrity

CORPORATE ETHOS FOR CLIENTELE The company is all set to test compounds for Biopharma on its platforms and profile them against metastasis and is currently in discussions with some MNCs and one Indian pharma. As for diagnostics, Mestastop has not covered this segment so far. Here, the research work cannot be based on ten patient samples and needs a much bigger sampling size. This project is ongoing, and soon Mestastop will enter the diagnostics field.

ENSURING CONSTANT GROWTH WITH R&D AND TECH ADVANCEMENTS R&D is everything in this field! Mestastop began with a hypothesis, but then data educates the team as they learn from it and modify their views. R&D is what sustains successful biotech and differentiates the good from the lucky ones.

DEBABANI ROY CHOWDHURY Founder & Director

“The Science we are following would not have been possible but for the technology currently available in our hands, thanks to all the innovative companies who design instruments, reagents, and kits. We work with purified tumor cells, which would not have been possible in high throughput a few decades back if not for the recent technological advances. We are also trying to integrate various other technologies into our work and working on creating some partnerships”, asserted Dr. Debabani Roy Chowdhury, co-founder and director, sharing her views on the involvement of tech solutions in the firm.

MESTASTOP’S INSIGHTS ON INNOVATIONS Innovation is nothing but challenging the status quo, asking questions not asked before and finding answers to them. For example, the node positivity status is the routine method of predicting the metastasis probability of a patient with a primary tumor but no visible metastasis. According to the data by the research team, negative node patients can still have metastasis, and conversely, node-positive patients need not have metastatic tumors all the time.

ACHIEVEMENTS & FUTURE PLANS Since Mestastop introduced the concept of the wet lab in November 2019, it has successfully presented its work at six international conferences. The company has filed two international patent applications and it has even been recognised as the “Best Metastasis R&D Specialist, 2022” by Global Health and Pharma, based in the UK. Its unique strength in science has attracted key angels and investors, and Mestastop has successfully achieved three fundings from the Government of India.

While Mestastop has successfully navigated through the journey till now by generating data with courage and resilience, it is yet to measure miles. In the future, the company is planning to set itself as the innovative hub of India which will compete with the best in the world. Here, the focus is to establish a platform where talented Indians returning to India will pursue innovation from day one and impact people’s lives.

TO WATCH IN 2022

Gulshan Parveen | Business Connect

DONATING BLOOD

Many people think donating their Blood is a great way to help others, and it is an act that saves lives. However, there are many other benefits of donating Blood as well. Even if you’re not in the hospital for surgery or medical reasons, there are many other ways in which Blood can help people around you. When you donate Blood, you are helping save many people’s lives. It may seem like a little thing, but every donation can help give someone the strength they need to get through their treatment or surgery.

In this article, we talk about the advantages of giving Blood and some unexpected things it can do for your loved ones and friends.

WHY SHOULD YOU DONATE BLOOD? One of the reasons why you should donate Blood is because it is a simple thing to do that can save someone’s life. Every second, someone in the world needs Blood for a transfusion, and less than 5% of those eligible to donate do so. Many people don’t realize they can give Blood until they are in the hospital receiving treatment and see the sign on the wall. It only takes about an hour or two to donate Blood, and you can save up to 3 lives by doing so!

HERE IS A LIST OF 6 SURPRISING BENEFITS OF DONATING BLOOD.

1. DONATING BLOOD - REDUCE HARMFUL IRON STORES: Iron is a natural component in your Blood, and it can be a lifesaver when someone is lacking in iron. However, some people have too much iron in their Blood, which can cause many dangerous health problems. Excessive iron storage can cause blood clots, tissue damage, organ failure, heart attacks, and other potentially fatal diseases.

If you or someone in your family has high iron levels, you may be at a greater risk of heart disease. High iron levels can cause heart attacks and other adverse health effects. The body naturally tries to store as much iron as possible, and donating Blood can help reduce these harmful stores of iron.

2. DONATING BLOOD - REVEAL POTENTIAL HEALTH PROBLEMS: Donating Blood can be another way to monitor your cardiovascular health, though it is not the same as going to the doctor. Before the Blood is drawn, you will undergo a brief physical examination during which your blood pressure, body temperature, haemoglobin, and other parameters will be checked. This occasionally reveals issues you were utterly unaware of.

Dietician and LEAP certified therapist Jan Patenaude says, “If your blood is too low in iron, the clinic will tell you and won’t draw your blood.” They will also let you know if they notice any other blood problems or if anything seems out of the ordinary.

3. DONATING BLOOD - REPLENISH YOUR BLOOD CELLS: Every time you donate Blood, you help replenish the Blood in your body. After, when your body uses that Blood and loses it, the red cells are replaced with new ones. If you don’t donate regularly, your body will have to work harder to keep up with the demand. Breaking down a pint of Blood leaves about a half cup of red cells for the body to use.

Your body also replaces platelets and plasma daily; however, this process is much slower than red cell replacement. Platelets must be replaced every 3–4 days for the body to maintain healthy levels in the bloodstream, and without regular platelet donations, a person can quickly become deficient in these cells.

4. DONATING BLOOD - KEEP YOUR LIVER HEALTHY Your health will benefit from blood donation. Giving Blood is a way to control the iron overload in your Blood, which damages your liver. One investigation discovered a connection between too much iron and Hepatitis C, liver cancer, and other unpleasant infections. Although it’s not a cure, giving Blood can help remove some extra iron and prevent it from building up too much in your liver.

5. DONATING BLOOD - LOWER RISK OF HEART ATTACKS: Your Blood can contain too much fat, cholesterol, and triglycerides (TG) or too little. Giving Blood regularly can help you out when it comes to your heart health. This is because the transfusion of donated Blood has been proven to lower the risk of a heart attack or stroke by as much as 25%, equivalent to taking 2 blood pressure medications. If you have high cholesterol, it’s best to talk with your doctor before donating Blood because this can lower your overall survival rate once you are diagnosed with a fatal illness. The standard cholesterol in donated red cells is meagre, though it depends on the donor.

6. DONATING BLOOD - LOWER YOUR CANCER RISK Too much iron in your Blood can raise your cancer risk by 500%! A study published in the American Journal of Epidemiology found that donating Blood regularly can lower your cancer risk by 10-20%.

Iron is a carcinogen; it helps promote tumor growth and cause inflammation. When donating blood, some excess iron is removed from the body, lowering the level of carcinogenic damage to your body. The best thing you can do to lower your cancer risk is to donate regularly and then keep an eye on any abnormal changes in your body.

CONCLUSION

Blood donation has a lot of advantages. You feel great after giving Blood! You get to make a difference in people’s lives while helping others. By giving blood frequently, you can monitor your health for potential issues before they become life-threatening and even avoid needing future medication. We hope you’ve found the muchneeded encouragement to do a service to humanity.

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