Healthcare Digitization: Making Services Accessible

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10 MOST INNOVATIVE DIGITAL THERAPEUTICS COMPANIES 2022 November ISSUE 04 2022 Need of the Hour Role of Digital Therapeucs in the Future of Healthcare Changing Trends Future Prospects of Digital Therapeucs Jean- Manassé Théagène Founder and CEO 360Medlink Medlink Pioneers of Digital Medicines 360
Beer Health and a better way of life.

Edit or’ s Note

Healthcare Digitization: Making Services Accessible

Digital technology has been driving a revolution in

healthcare, frommobilemedicalappsand softwarethatsupportclinicaldecisionsdoctors makeeverydaytoartificialintelligenceandmachine learning.Digitalhealthtoolshaveenormouspotentialto improveourabilitytoaccuratelydiagnoseandtreatdisease, aswellastoimproveindividualhealthcaredelivery

Digitalhealthischanginghowdoctorsprovidecare,what patientsdotogetandhowhealthcaresystemswork.Mobile health(mHealth),healthinformationtechnology(IT), wearabledevices,telehealthandtelemedicine,and personalizedmedicineareallexamplesofdigitalhealth.

Throughdataaccess,digitaltoolsareprovidingproviders withamoreholisticviewofpatienthealthandgiving patientsmorecontrolovertheirhealth.Ithasthepotential toimprovemedicaloutcomesandincreaseefficiency.These technologieshavethepotentialtoempowerconsumersto makemoreinformeddecisionsabouttheirownhealthand toprovidenewoptionsforfacilitatingprevention,early detectionoflife-threateningdiseasesandchroniccondition managementoutsideoftraditionalhealthcaresettings.

Smartphones,socialnetworksandinternetapplicationsare notonlychangingthewaywecommunicate,butitisalso providinginnovativewaysforustomonitorourhealthand well-beingandprovidinguswithgreateraccessto information.

InsightsCare'snewedition10MostInnovativeDigital TherapeuticsCompanies2022helpsusunderstandthe innovativedigitalsolutionsthathelptechnologistsin navigatingnewchallengesandmeetthechangeddemands ofthepatientineverydaylife.

Hope you have a terrific reading!

C O N T E N T S

360Medlink

Pioneers of Digital Medicines

08
Articles 16 Learn Laugh Speak Read, Write, Speak and Listen English—Anywhere, Anytime 32 Ōmcare 24 We are Leaving them Behind CxO Future Prospects of Digital Therapeutics Changing Trends 20 Role of Digital Therapeutics in the Future of Healthcare 28 Need of the Hour Enabling One-touch Access to Healthcare and Dose-level Medication Adherence

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Description Company Featuring Person

360Medlink 360medlink.com

Alcimed alcimed.com

Emerald Health Therapeutics emeraldhealth.ca

Evidera evidera.com

Forma Therapeutics

formatherapeutics.com

Horizon Therapeutics

horizontherapeutics.com

Learn Laugh Speak learnlaughspeak.com

Ōmcare omcare.com

OTO joinoto.com

PTC Therapeutics ptcbio.com

Jean-Manassé Théagène CEO

Victor Forestier Director

Duncan Clokie Communications

360Medlink Inc. is a software company specialized in healthcare providing validated Digital Health Platforms and Digital Therapeutics (DTx) to optimize patient care and improve access to vulnerable populations.

Alcimed is an Innovation and New Business consulting firm specialized in sectors driven by innovation : life sciences (biotech, healthcare, food), energy, environment, chemicals, cosmetics, materials, building, transportation, aeronautics, space and defence.

Emerald Health Therapeutics, Inc. was acquired by Skye Bioscience, Inc., a San Diego-based pharmaceutical company developing proprietary, synthetic cannabinoid derivatives to treat glaucoma and other diseases with significant unmet needs.

Susan Couch Mkt and Communications

Suzanne O'Connell

Jeff Sherma Vice President and Chief Medical Officer

Bryce Purnell Founder/Director/ Teacher

Evidera is a business within Pharmaceutical Product Development, LLC, (PPD) a leading global contract research organization (CRO), and is the preeminent provider of evidencebased solutions to demonstrate the real-world effectiveness, safety, and value of biopharmaceutical and biotechnology products from early development through loss of exclusivity

Forma Therapeutics is a clinical-stage biopharmaceutical company focused on the research, development and commercialization of novel therapeutics to transform the lives of patients with rare hematologic diseases and cancers.

Horizon Therapeutics believe science and compassion must work together to transform lives. It is driven to deliver innovative medicines to those living with rare, autoimmune and severe inflammatory diseases because it uniquely understand the patient journey.

Learn Laugh Speak’s program has been designed to help anyone and everyone achieve English fluency, regardless of their current level of proficiency. With its help, you'll be able to communicate with confidence in any situation - from business meetings to social gatherings.

Ōmcare is a digital health company that aims to change the way the world cares by extending the reach of caregivers, increasing medication adherence, and improving treatment outcomes through the power of remote care and two-way video technology

George Leidig Co-founder

Oto goes beyond tinnitus therapy. Its personalised program is designed to help you reclaim your life and regain your sense of peace and calm.

Communications

PTC is a science-driven, patient-centered biopharmaceutical company focused on discovering, developing & commercializing medicine for patients with rare and serious disease.

Jeanine Clemente Global Corporate Lisa Lavin CEO
10 Most Innovave Digital Therapeucs Companies 2022

360

Medlink

Pioneers of Digital Medicines

The journey has been good so far! Like every company, we have had our moments of highs and lows, somewhat of a roller-coaster. But in essence, it feels great today to see that what I envisioned for digital therapeutics over 15 years ago has become pure reality.

Cover Story 10 Most Innovave Digital Therapeucs Companies 2022
Jean- Manassé Théagène Founder and CEO 360Medlink

Apatientissaidtobe ‘vulnerable’whencertain disparitiesexist,suchasthe lackofaccessibilitytoeffectivecare servicesorhighhealthcarecosts.To eliminatethese,thehealth technologistsareworkingeverydayto navigatechallengesandmeetthe changingdemandsofthepatients.In theirattemptstobestservethe vulnerable,newmodelsofcareare defined,andaffordabilityisaddressed.

360Medlink,ispartofthesolution thatstrivestoprovidehealthcarefor vulnerablecommunitiesbyensuring thatcareismadeculturallycompetent andequitable.Itsinnovativedigital solutionisstructuredtoeliminate existinghealthdisparitiesandprovide evidence-basedinterventionstoat-risk populations.

Jean-ManasséThéagène,the FounderandCEOof360Medlink, managestoadjustthecompany's operationsandredefinethebusiness modeltoimprovethelivesofpatients livingwithrarediseaseandchronic conditionsandempowerthemintheir treatmentjourneys.

WeatInsightsCareMagazinestriveto haveacloserlookintothejourneyof 360Medlink,throughManassé’sown words.

BringingtoLight:TheDigi-Concept

Beforestartingthecompany, Manassé'sfirstsourceofinspiration wasthefactthathewasintrigued aboutonhowtoimprovethelivesof somanypatientswhohavepooraccess tohealthcare,lowerqualityofcare, andaretheleastcapableofaffording goodcare.Later,itcametohimthata keyvectorthatcanpositivelyaffectall

ofthatinstantlyistechnology Alreadyasearlyas2010,360Medlink wasconsideredtobeapioneerplaying withtheconceptofDigitalTherapies, followingpreviousexperienceof launchingoneofthefirstalgorithmbased(nowadaysArtificial Intelligence)diagnostictoolsfornoninvasiveliverdiseasestaging.

Aroundthattime,healsohadworking experienceinthepharmaceuticaland diagnosticindustryinternationally, whereherealizedthattherewouldbea placeforahealthcare-focused technologycompanytosucceed.

“It all became clear to me that soon in the future, the FDA and other country regulatory agencies will have to recognize the medical benefits of customized software solutions almost as equal to drugs and devices. And most likely it would be called something along the lines of digital therapy, digital medicine or digiceutical,”statesManassé. TodaythetermsDigitalTherapeutics (DTx)hasbecomethenorm.

FromStart-UptoGlobalStrategic Partnerships

Manasséshareshisjourneywith peoplewhomadeitenjoyableforhim, bothinthepastandpresent.For example,theverymulti-cultural chemistryofthecompany.Or,there wasaperiodwhen40%of360Medlink staffwerewomen,whichwasarather exceptionalthingforatechnology companybackthen.

Hehaswalkedandexperiencedgrowth withpeoplewhocamefromallsortsof disciplines,beliefsandethnicities.

“The journey has been good so far! Like every company, we have had our

moments of highs and lows, somewhat of a roller-coaster. But in essence, it feels great today to see that what I envisioned for digital therapeutics over twelve years ago has become pure reality,”addsManassé

HeagreesthatCOVID-19had certainlyhelpedacceleratethedigital healthtrendthat,graduallyandslowly, wastransforminghealthcare.From beingastart-upmanyyearsago,itis nowapartnerofchoicefor pharmaceutical/biotechcompaniesand healthcareagencieswhoseekto improvetheirproductbyofferingtheir supporttopatients.Withitsportfolio ofDigitalMedicinesandSoftwareas MedicalDevice(SaMD),thecompany isnowhittinganinflectionpointinits journey.

ABlendofDifferentiatedValues

360Medlink’scorevaluesarebasedon andhaveemergedfromthekindof upbringingthatManasséhad experiencedwhilebeingsurroundedby alargefamily

Firstly,thecompany’svaluesmutual respect.Itisconsideredimportantto respectthedifferenceinexpertise, culturaldiversity,andsoon.Therefore, everymembermustfeelfreetoexpress themselvesandcontributeasmuchas theycan.

Thesecondvalueiscreativity,which prioritizestheneedforinnovationas 360Medlinkisatechnologycompany playinganimportantmissioninthis unprecedentedperiodofhealthcare transformation.Everyteammemberis encouragedtobringnewideas,test newthings,andhelpusallbuild innovation.

It all became clear to me that soon in the future the FDA and other country regulatory agencies will have to recognize the medical benets of customized software solutions almost as equal to drugs and devices. And most likely it would be called something along the lines of digital therapeutic, digital medicine or digi-ceutical.

Thirdly,360Medlinkvalues perfection,wherealthoughnotevery teammembercouldbeperfect,they mustseekperfectionintheirrolesand theirdeliverables.Inotherwords,it believesinleadingbyexampleand constantlystrivingforthehighest quality

“These values are inextricably linked to 360Medlink’s core mission which is to build clinically validated digital therapies in specialty conditions, with a particular focus on special populations. By achieving this mission, we believe we will help make healthcare more accessible and affordable to all, especially for vulnerable communities,”suggests Manassé.

RenderingRemarkableSolutions

360Medlinkoffersascientifically testedrangeofsolutionstovarious verticalsfrompharmaceutical corporationsandgovernmentagencies tohealthinsurancecompanies.Inthe process,itstillmanagestostandout competition.

Toattaintheobjectiveandstandout, 360Medlink’soperationsrunoncertain keyaspectsofdifferentiationwhich are:

· Thecompany’sthreelinesof digitalplatformsare complementary;therefore,it providesthebenefitofaOne-Stop shop.

· Itssolutionsareswifttodeploy, cost-effectiveandeasilyscalable.

· Ithasexpertiseinspecialty conditionsandalonglistof successestoshowit.Itholdsa professionalteamwhocomesfrom extensiveexperienceinlifesciencesandmedicaldomains.

· The360Medlinksolutionshave improvedclinicaloutcomes, increasedusersatisfactionand receivedpositiveendorsements internationally

QualityofServiceandCustomer Delight

Manasséelaborateson360Medlink's servicebysharinganinstancewhere heworkedwiththestateofRhode Islandandtheirpatientslivingwith HIV.Overrecentyears,thecompany managedtohelpthestateHHSaddress anotableproblemofpatients disconnectingfromcare,fading treatmentengagementandsub-optimal adherence–allthroughitsdigital interventions.

WiththeuseofClinikly.ai(formerly TAVIE),adigitaltreatmentcompanion, thecompanyhelpedimprove reinsertionincare,patientandcase managersatisfaction,andincrease treatmentadherence(87%to98%), measuredbypatientswhohave achievedviralloadsuppressionas observedoverfouryears.

Manasséattributed,“Such a success must not be solely based on the digital therapy but also on the quality of service that the joint teams (360Medlink and Rhode Island case managers) were able to deliver to meet numerous unanticipated field challenges or difficulties considering the complex and specific needs of that special population.”

OperatingonHealthcareInnovation andArtificialIntelligence(AI)

360Medlink’sfast-pacedclinical operationsaremanagedbyClinikly.ai (formerlyTAVIE),aflagshipproduct

thatisoneofthemostholisticpatient supportprograms(PSP)applications.It istheidealdigitaltreatment companionwithseveralhealth essentialfeatures.

Itsfirstkeyfeatureisthevirtualcoach platformthatcomesfromthecognitive behaviorchangemodel,tohelpbuild self-efficacy.Otherimportantfeatures offerpatientsengagingitemsfor education,support,resources,andfun (gamification).Clinikly.aiis complementedbytwoadditional platformsforremotecaremanagement (RCM):onefortheproviderHCPor casemanagersandoneforthesponsor (orpayor)forpopulationhealth,real worldevidence(RWE)anddata management.

Basedonamedicaltreatment guidelinesbytherapyconditions, proprietaryalgorithm(technology)and ArtificialIntelligence(AI),theapp offersaverypersonalizedexperience tothepatientinavarietyofcultural, languageandliteracyadaptations.

ConcludingNote

Inanerawherecustomersdemand cost-effectiveaccesstohealthcare,the expectationsforgoodqualitypatient carehavebeenswitchedtohypercustomization—forwhich, 360Medlinkisanidealsolution.

Withitsvastanduniqueportfolioof SaaSreadydigitalmedicineplatforms, thecompanyhasproventobea reliablesolutionpartnerfornotonly theprivateandpublichealthcare stakeholdersorpayors—butalsoin creatingmemorablecareexperiences forthe‘vulnerable.’

Stay in touch. Subscribe to Insightscare Get Insightssuccess Magazine in print, & digital on www.insightscare.com Check should be drawn in favor of : INSIGHTS SUCCESS MEDIA TECH LLC

Learn Laugh Speak

Read, Write, Speak and Listen English —Anywhere, Anytime

Intheglobalizedecosystemthatwelivein,language hasbecomeaverysignificantbridgethatconnects people,irrespectiveoftheirregion,cultureandvarious otheridentities.Language,beingtheprimarymodeof expression,isdirectlyconnectedtothesocialwell-beingof anyindividual,ultimatelyimpactingmentalhealthdueto thealienationcausedinamulticulturalsetting.

Imagineyouareinaprofessionalspacewherethemajority speaksEnglishandtheyfindithardtocomprehendregional orothernationallanguages.WherewouldthisleadanonEnglish-speakingindividual?Howwouldthatindividual managetheprofessionalandcasualinteraction?

Itisobviousthatsocialisolationcausedduetolanguage barrierwilltakeadeeptollonone'shealth.

ThiswasrealizedbyBrycePurnell(anEnglishTeacher) whenhewashospitalizedforthreeweeksandobservedthat manydoctorslackedEnglishcomprehensionandspeech fluency,causinginconveniencetomanypatients.

Uponinquiry,Brycefoundthatnon-nativespeakersfind discomfortinthelanguage,whichbecomesaroadblockfor themtolearn.

Mitigatingthisfearandempoweringnon-nativespeakersto expressthemselvesefficiently,LearnLaughSpeak—an Englishlearningplatform,tookanintuitiveapproachto teachitsstudentsthroughstructuredlearning.Underthe standoutleadershipofBrycePurnell,theFounder, DirectorandTeacherofLearnLaughSpeak,thisonline academicschooldeliversitsprogramtolarge-scale

companies,ensuringthateachpersonacquiresaunique experienceandEnglishproficiencytailoredtotheircurrent knowledgeandneeds.

Let's dive in and learn what Learn Laugh Speak has to offer

Bryce,kindlybriefusabouttheLearnLaughSpeak companyandtheideasthatledtoitsinception.

LearnLaughSpeakwascreatedfromtheideaofhow difficultitisforadultstomakeprogresswhenlearning Englishincompanies.AsIsetouttofindsomethingnew,I movedtoMexicobecauseofmyloveforthecountry

ImovedthereandstartedteachingEnglish,realizingthat therewasamassivedisconnectbetweencompanieswanting theiremployeestolearnEnglishandstudentsneedingto learnEnglish.Withoutanywaytotrackrealprogressand nosystematicwaytolearnsuchacomplextopic,Iknew therewassomethingwecoulddotochangethis.

Whatarethekeyoperationsrunbythecompanyto servetheirneedsinacquiringtheskillnecessaryforthe Englishlanguage?

Weuseadvancedvoicerecognitiontoprovide33,000 lessonsthatcoverreading,writing,speakingandlistening. Thekeybenefitforstudentsisthateverystudentlearnson theirowncustomjourneyspecifictotheirlevel.Wetarget adultEnglishlearnerswhoaretoobusytogettoclassoneon-onewithateacher.Grouplessonsforadultstudentsjust donotwork.Soweensurethateverystudentcanlearn

10 Most Innovave Digital Therapeucs Companies 2022
16|November 2022|www.insightscare.com

whentheywant,wheretheywant,andasmuchoras littleastheywantperday

WhataretheuniquequalitiesofLearnLaughSpeak thathavedistinguishedyourservicesfromothers?

WearetheonlyapplicationforlearningEnglishthatis fullyalignedwithalltheinternationaltesting parameterssetbytheCommonEUframeworkof referencefortesting.OurEnglishprogramcovers reading,writing,speakingandlisteningandis recognizedforlearningby44countriesandcanbeused bystudentslookingtopassimmigrationtestsin Australia,Canada,theUSA,etc.

ImightaddthatLearnLaughSpeakistheonly companyfounded,created,operatedanddirectedby nativeEnglishteachers.WearebasedinSydney, Australia,whilemostofourcompetitorsarenotfrom nativeEnglish-speakingcountries.

Bringingauniqueapproachfromabusinessperspective andasanativeEnglishteacheriswhatIbelievesetsus apartfromothercompaniesintheworld.

Pleasebriefusabouthowthecompanyhasmanaged toattainaglobalreachofclientstoday.

Wehavemanagedtoclimbto4,000usersinthelast fewmonths.Wearedoingwellwithourstudents.I havenointentionofpushingthiscompanybeforethe endoftheyear.Nextyear,wehavesomeplansonthe horizonwithacoupleoflargeinternationalcompanies.

Ihavemadeapointtomysmallteamthatweneedto ensurethatwehaveourstudents'journeyssmoothand correct.Wearealreadyworkingwithoverten internationalcompaniesthathavemultipleteamsusing ourapplications.Ioftengetreferralsfromthese companiesasourapplicationsdowork.Studentsdo learn.Wedonotneedtohaveastrategyorplanfor globaldominationwhenIknowwhatwearedoing works.

Howareyoumakinganimpactinthelivesof learners?

LastnightItoldmygirlfriendthatmymissionherewas alwaystohelppeoplewhocouldnotlearnEnglishdue

the progress they make.

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For anyone who desires to learn English, I urge them to reach out to me directly, give our application two weeks of learning, about three hours per week, or 20-30 minutes per day, and see

tomanyfactorsbettertheirlives.Fromcompanies providingmyapplicationstopeoplecurrentlylivingin smallvillagesinMexico,tothemspeakingEnglish.

Someofthesestudentsneverwenttoschool.Theydidnot havetheopportunitytolearnEnglish.ThisiswhatIdothis for.Ibelievepeopleintheworldshouldhaveaccessto English,andiftheywanttobettertheirlivesthrough English,theyshouldbeableto.Thisisnolongerabout whetherpeoplewenttouniversity.Iwanttohelpthosewho wanttolearn.

HowcanLearnLaughSpeak'ssoftwarehelptoimprove DigitalTherapeuticsforthetreatmentofmedical disordersordiseases?

Ayearago,Iwasillwithsomethingthatnearlytookmy life.Asaresult,Ispentaroundthreeweeksinahospital, fightingformylife.NotallthedoctorscouldspeakEnglish, whichworriedme.

Atpresent,someofthesedoctorsarenowusingmy application.Ithinkallmedicaljournalsintheworldare printedinEnglish,andtheneedforEnglishinthissphereis massive.Toincreasetheirknowledge,andlikeIsaid,adults needtolearn.Theyhavethechancetolearnnowwithus.

Theydonotneedtoattendembarrassingclassesthattakea greatdealoftime.

Asanexperiencedleader,whatadvicewouldyouliketo givetoenthusiastswhoareaimingtotransformthe healthcareindustrythroughlanguagetraining?

Iencouragethemtogiveourapplicationsago.Wedonot provideanythingbutsimpleprogressinoneofthespheres needed.

Iurgethemtoreachouttomedirectly,giveourapplication twoweeksoflearning,aboutthreehoursperweek,or20-30 minutesperday,andseetheprogresstheymake.Notonly willtheyfindtheirconfidencelevelgoup,butoursoftware willalsoencouragethemtomakemistakes.

Whatarethefuturegoalsofthecompany?Howdoyou envisionupscalingitsoperationsandreachin2022and beyond?

IsoonplantofinishsettingupourLatinAmericanoffice.In thenearfuture,weplantoopenourbusinessdevelopment officeinNewYorkbyearlynextyear Althoughmyheart livesinMexico,andmyloveforthiscountryissostrong withmypartnerandherfamilyhere.Iwillventurebackto Sydneyinthecomingmonthstoseemyfamilyfor Christmas.Thenextyear,inJanuary,wewillhaveour officeopeninthebigapple.

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FutureProspectsof

Digital Therapeutics

Thehealthcareindustryisundoubtedlyinthemidst

ofadigitalrevolution.Thistransitiontodigital healthisapromisingglobalstrategytomeetthe challengesofthehealthcareindustry Accesstohealthcare andcontinuityofcarearenecessarytoday Weare witnessingtheriseofconsumerisminhealthcare,where patientsandconsumersaremoreactiveandengaged,want tocontroltheirhealth,andaremoreopentopreventiveand preventativemeasures.Digitaltherapiesareemergingand disruptivetechnologiesthattranscendtheboundariesof place,timeandaccesstohealthcareresources.

Thesesoftware-based,intelligentandeasy-to-usetreatment solutionsprovidepatientsandhealthcareproviderswith high-quality,safeandeffectivedata-driveninterventions.

Digitaltherapyisthekeytomovingfromreactive healthcaretoproactiveholisticcare.Usingtechnologies suchasArtificialIntelligence/MachineLearning(AI/ML), AugmentedReality/VirtualReality(AR/VR),mHealth applicationsandgame-basedplatforms,theseevidencebaseddigitalinterventionprogramsofferon-demandremote accessforpersonaltreatmentofvariousdiseases.

Byanalyzingpatientdataandusingadvancedanalytics,AI providesmorepersonalizedsupport.Additionally,usingAI predictiveanalytics,patientdataisusedtocreatean effectivemodelingtoolthatpredictspatientprognosisand needs.Virtualandaugmentedrealityhelpswith visualizationindigitaltherapiesandcreatesanengaging environment.Theyarehelpfulinself-directedrehabilitation

ChangingTrends 20|November 2022|www.insightscare.com
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exercisesforpainreliefandtreatmentofmentalhealth disorders.Theuseofgamificationindigitaltherapy platformsimprovesandpromoteschangesinthepatient behavior;itappliestochronicdiseaseplatformsand behavioraltherapyplatforms.

The below section highlights the prospects of digital therapeutics:

EnablingPreciseCareforaRangeofIndications

Withpersonalizedandevidence-basedtreatmentprograms, digitaltherapyisvaluableforavarietyofindications.Most digitaltherapyfocusesonmentalhealthproblems,followed bydigitaltherapyforchronicdiseasessuchasdiabetesand hypertension.

Physiotherapyorrehabilitationdigitaltherapyismore interestingthantraditionalphysiotherapyinahospital.An immersiveenvironmentusingAR/VRandagamified rewardplatformimprovesengagement,andclinical outcomes.Pharmaceuticalcompanieshavenothadmuch successintreatingneurodegenerativediseasessuchas Alzheimer'sdiseaseormultiplesclerosis.Digitaltherapyis anavenuethatseveralpharmaceuticalcompaniesare exploringthroughpartnershipsandcollaborations,suchas BoehringerIngelheimworkingwithClickTherapeuticsto developdigitaltherapyforschizophreniapatients.

Cancertreatmentisoftenlongandcomplicatedandhas serioussideeffects.Oncologistshaveturnedtodigital therapiesandtechnologiestoimproveoutcomesforcancer patients.Thisisanotherdiseaseindustrythatiswitnessing collaborationandpartnershipbetweenbigpharmaand digitalcompanies.Forexample,VoluntisandBristol-Myers Squibbaredevelopingdigitaltherapiesforoncology. Managinggastrointestinaldisordersinvolvesbehavioral andlifestylechangesanddigitaltoolsenablesuchchanges.

KeyGrowthOpportunitiesforDigitalTherapeutics

Digitaltherapyofferspharmaceuticalcompaniesan attractivevaluepropositionthatoffersthebenefitsof holistictreatmentbeyondpills.Asclinicalevidencefor

improvedhealthoutcomesgrows,pharmaceutical companiesareembracingdigitaltherapyandexpanding theirinvestmentsindigitaltherapyR&Dandtechnology development.

Digitaltherapydoesnotreplacemedicine;However,when digitaltherapyiscombinedwithdrugtherapy,itimproves patientengagementandadherence,inducesbehavioral changes,offerspersonalizeddosingandeducatesand guidespatientsaboutsideeffectsandself-caretechniques. Theindustryhasseenanumberofsuccessfuldigital therapystartups,andsomehavequicklyachievedunicorn status.However,pharmaceuticalandMedTechcompanies shouldtakeadvantageofthegrowthpotentialofdigital therapythroughtechnologicalconvergence.Thisapproach canbeinitiatedthroughpartnershipsandacquisitionswitha softwaretechnologyordigitalhealthcompany

Digitaltherapyalsooffersgreatvaluetopayers,especially thoseinterestedinvalue-basedcare.Digitaltherapyoffers betterclinicalandhealtheconomicoutcomesbybetter managinghealthstatus,reducingdiseaseprogressionand loweringoverallhealthcarecosts.Itisimportantto documenttheeffectivenessandhealthoutcomesassociated withthetherapysothatpayersareawareofthebenefitsof digitaltherapy.Itisalsoimportanttoemphasizethevalue ofreal-worlddataasithelpsanalyzepopulationhealth outcomesandpopulationhealthmanagement.

WrappingUp

Thefutureofhealthcareisaparadigmshiftfroma prescriptiveapproachtoamoreproactiveand comprehensivetreatment.Digitaltherapiesareusedto predictandmanageapatient'sfuturehealthratherthan respondtosymptoms.Thisevolvingapproachtocarewill undoubtedlyhaveahugeimpact,especiallywiththe integrationofadvancedAIanalyticsandbetter interoperablehealthcaresolutions.Thishelpsreducethe burdenofdiseaseandisagreatvaluepropositionfor insurancecompaniesandhealthcareinstitutionsduetocost savings.

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We are Leaving them Behind

Weinnovateandbringnewtechnologytomarket

fasterthaneverbefore.Thenumberofmedical devicesbeingintroducedtohealthcareprofessionalsin2022isbreathtaking,andthereisnosignof slowdown:quitetheopposite:COVIDhascreateda desperateneedforadditionalrevenuestreamsandincreased pressureonfinancialviabilityincompaniesthathavebarely survivedthepandemic.

“MedTech companies must have made billions during the pandemic.”

OftenIheartheincorrectperceptionthatallhealthcare companiesmusthavedonewellduringthepandemic;in fact,theoppositeistrue.TheonlyareasthatreallyflourishedwerePPEandventilationandarangeofdrugs.The restwereinfreefall:surgicaldevicesusedroppedoffacliff duringthelockdownandhasremainedlow.Elective surgerieswerepostponed,andnowweseeyearsofdemand, butadecimatedworkforce,overworkedandunderfunded, withanenormousmentalhealthbilltopayforthoseonthe frontlinesstillpayingthepriceoftheirheroicefforts.

HearingtheCEOofClevelandClinicLondon,Brian Donley,voicehisinsightfulthoughtsaboutthegapin organizationsaroundtheworldwithregardstoavailable techandthelevelofeducationinstaffmemberslastweek atameetingarrangedbyEuropeanHealthcarePrivate EquityAssociation(EHCPEA)andMcDermottWill& Emery,heisofcoursespoton,andshowingtheskillsofa strongandstrategichealthcareleaderin2022.Cleveland Clinicisattheveryforefrontofinnovationinmedicine, withthetopsurgeonsandcaregiversintheworld.IfTHEY haveidentifiedagap,itgoeswithoutsayingthatthegapin

JUST BECAUSE WE CAN DESIGN A BETTER DEVICE, DOESN’T MEAN WE SHOULD, NOT WITHOUT DESIGNING THE ROADMAP OF BRINGING OUR USERS WITH US.
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About the Author

Angela Spang is the Founder & Owner of JUNE Medical Global. She is the inventor of the award-winning Galaxy II® self-retaining retractor and receiver of Her Majesty Queen Elizabeth II Award for Innovation in 2021. She is a published author, with her first book “Outspoken – What I Never Told Anyone” securing the #1 Best Seller spot on Amazon.

She lives in Buckinghamshire, England with her husband and two children.

25|November 2022|www.insightscare.com

publichealthcaresystemsaroundtheworldwillbe absolutelymind-blowing.Andneithertimenorfundsare availablepost-COVIDtoclosethegap.

ImpactonInnovation

Whilecompaniesstrivetoinnovatebetter,faster,and disruptively,theirinnovations’usersarefallingincreasingly behind.Theinterestandacceptanceofnewtechnologyis dwindling,andsoaretheeconomicresourcesfor introducingsuchtech.Thebiggertheleapforward,the higherthehurdle.Effectively,weareputtinghandcuffson innovationand,atthesametime,demandingmore investmentfrommedicaldevicecompanieswithchanging regulations,additionaltaxes,andthecostofmaterialand productionskyrocketing.

Internationalconferencesforsurgeonshavebeenatelling signforyears:theexhibitionhall,whichusedtohouseall thebignewlauncheswithexcitingrevealsofnew innovativedevices,isnowaquietandslowaffair,theonly visitorstostandsbeingotherindustryrepresentativesfilling thetimeandforgingrelationshipsthatmaycomeofuse whenitistimetochangejobs.Theyarenoteventhereto gaincompetitiveadvantageanymore;theknowledgeof competitivedevicesisasadvancedasthetrackingofnew launchesandhasmovedawayfromthebigarenasontothe internet.

Nobodyhastime(orbudget)towaitwithamarket introduction,sothebigshowsareallgone:thetimeswe spenthundredsofthousandsonlauncheventswith hundredsoftopsurgeonsattendingaregonetoo;assoonas companiesobtainapprovalfornewdevices,theyneedto launch.Evenmonth’sdelayedrevenueisthedifference betweenmakeandbreaksforanewproduct.Notimeto waitforthenextconference,andeveniftherewastie, launchinginanemptycongresshallwhereattendeesare moreinterestedinseeingcolleaguesandcatchingup sociallyisano-goforthemarketingteam.

ImpactonCare

Whennewstravelfast,theyalsoimpacttherelationship betweenhealthcareprofessionalsandtheirpatients.For years,‘DrGoogle’hasbeenhardatwork,diagnosingand suggestingtreatmentsforpatientsallovertheglobe,tothe frustrationanddismayofmanyGPsfacedwithprintoutsof symptomsandtherecommendedtreatments.Whileselfassessmentcanbeausefultoolforaphysiciantotakeinto

accountastheyevaluatetheindividualinfrontofthem,a patientconvincedtheysufferfromararedisordernotseen sincethe1700canindeedbemoreharmfulthanhelpful. Thepressureontimeisn’thelping;itishardenoughto understandwhatisactuallywrongwithsomeonewithout havingtospendtimedebunkingmythsfromtheinternet.

Theconstantreminderofthingswedon’tknowchipsaway atconfidenceaswell;nodoctorwillbeaffectedbytheodd patientsconvincedtheyarewrong,butwhenseveral(all?) meetingseverydaystartwithhavingtodefendone’sown educationandreasonsofbeingadoctor,eventhesturdiest ofprofessionalstendtostarttowobble.Doctorsaretraining toavoidriskatallcosts,butwithadditionalquestioning,we allstarttosecond-guessourabilities.Whentryingto rememberifweclosedthefrontdoororputsaltonthepast, thisisfairlyharmless.Whenitaffectsadoctormakinglifechangingdecisions,doubtandlackofconfidencearenot justdangerous,itispotentiallylethal.

Don’tgetmewrong,Iamasmuchforahealthydoseof self-assessmentasthenextperson,butIamalsoacutely awarethatthereisahealthylevelandthenaharmfullevel.

We(Innovators)NeedtoChange

Soifinnovationisgoingtoofastandweareleavingusers (customers)behind,howdowecontinuetodrive improvementincareinasafeandeffectiveway?Ordowe blindlyandnaivelycontinueforward,notaddressingthe increasinggapbetweenwhatweCOULDdoandwhatwe areCAPABLEofdoingashealthcareprofessionals?

Intelligentandresponsibleinnovatorsnowtakeastepback andlookatinnovationinhealthcaredifferently.Thedays wherewecanjustinnovateinthingsaregone;wemust thinkbroader.Wemuststartwithassessingnotjustwhat usersneedorwhatwouldmakehealthcarebetter,butalso assesswhatthelifecapabilitiesareinhealthcare,andhow tobridgethatgap.JustbecauseweCANdesignabetter device,doesn’tmeanweshould,notwithoutdesigningthe roadmapofbringingouruserswithus.

Assessingnewinnovationneedstomovefromitsfairly limitedscopeofuserrequirementstoabroadersetof criteria:readinessofnotjustadoptingandimplementing saidinnovation,butalsothecapabilityofentire organizationsaswellastheimpactandresponsefrom patients;thesewillallbehighlyrelevantcriteriaimpacting theroadtoadaptationofanynewtechnology.

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Digital Therapeutics

Role of in the Future of Healthcare

Technologyhelpsuseverystepoftheway.It

reinforcesourbehaviorandcrystallizesour understandingoftheworldthroughthemeanswe usetointeractwithit.Webaseourlivelihoodsonthese systemsanddependontheirprogressasourneedschange andourcapabilitiesgrow

Healthcaretypifiesthisexperienceinthemostpersonal sense.Whenconsideringtreatmentoptions,healthcare professionalshavebeguntolookbeyondconventional prescribingmethodstoadoptnewandunconventional interventionstoimproveanddeliverthepatientexperience. DigitalTherapeutics(DTx)embodiesthisstandardof change.

DTx,whilelooselydefined,includesand"deliversmedical proceduresdirectlytopatientsusingevidence-based, clinicallyevaluatedsoftware."Theaccessibilityofmobile technologyforthispurposehasfueledaproductivityboom,

Need of the Hour 29|November 2022|www.insightscare.com

makingtheDTxmarketoneofthefastest-growingand arguablymostexcitingtrendsinthepharmaceutical industry

TechandPharmaCollaborations

Itisnosecretthatpharmaceuticalcompanieshavedevoted considerableresourcestothis.Exploringtheopportunities inthespacegiventheindustry'smeasuredunderstandingof whatkindofintegrationthesetechnologieswillrequirein thefuture.Onesuchnotableexampleofthistypeof investmentistherecentDTxcollaborationbetweenSanofi andHappify

ThisprojecteffectivelytargetsMSpatientsandaimstohelp improvementalhealthoutcomesalongsideconventional treatments.InMS,patientsaretwotofivetimesmoreprone todepressionandanxietythanthegeneralpopulation.The startingpointforsuchinterventionsmustbetheimpactthat poormentalhealthcanotherwisehaveontreatment outcomes,withpatientssubsequentlyoftenstrugglingwith follow-upandqualityoflife.Itprimarilyservesa supportivepurpose,complementingstandardcoursesof treatment,andhelpingpeoplemanagetheirwell-being moreholistically.

Thisapplicationcontainselementsofgamificationasaway tomeaningfullymarketintrospectionandpersonal developmenttechniques.Suchmediarepresentanew digitalcommunicationstandardthatputsthepatient experiencefirst.Providingindividualswithaseamless journeyfromstarttofinish,allatthefingertipsoftheir mobilephones.

IntegratingDigitalHealth

Asapioneeroftechnologicaldevelopment,oneoftenhasto faceacertaincynicism.Afterall,themarketisnota benevolentforce,andthussuccessrequirestime,friction, andacommonunderstandingofwhereandwhenyour productwillsell.Thesetechnologiesarestillinthe formativestagesoftheirlifecycle.Perhapsthemost transformativechallengeintheirdevelopmentisconvincing therightpeopleoftheirvalue.

Thepharmaceuticalindustryhashistoricallypresenteditself asaconservativeinstitutionboundbyrigidbutimportant protocolsandstandardsofevidence.Soitshouldcomeas

nosurprisethatdoctorsareinevitablytheoneswhodecide howtosupplementthesesolutionswithprescriptiondrugs. Themediatorinthiscaseiseducation.HCPsneedareason tousethesetechnologies.Notasdirectalternatives,but becauseofthegraciousbenefitsofferedwhencombined withtraditionalrecipes.

TheapplicationofDTxmustbeunderstoodindetail,notin thesamewayasweevaluatetraditionaldrugoptions.Their effectiveimplementationismoreindividual.Theproblemis thatitisarelativelydemandingprocessthatrequiresahigh levelofpersonalcommitmentfrompatients.Afterall,it's notthesameastakingpills.Therequiredcontentdeliveryis suchthatHCPsreceivehands-oneducationonthe effectivenessandpracticalityofthesetechnologies.Which inturnhelpstoinformandmorecriticallyinfluencethe effectiveuseofservicesamongpatients.

LookingAheadIntotheFuture

Thesesolutionsplayanincrediblyimportantrolein advancinghealthcare,helpingtoimprovepatientoutcomes bychangingthepatientcenterconversationinawholenew way.Thenearfuturewillcertainlyshowwhatrolethey havetoplayinthecompleterecipe.Educationproviders mayholdthekeytounlockingthepotentialofthese technologies.

Patientsneedtobegivenguidance,whilehealthcare professionalsneedtheinformationtoreliablyguidethemto thebestsolutionsfortheircondition.Aligningtheseneeds andcreatingaconversationthatfacilitatesinformationwill onlyservetobetterconnectdoctorsandpatients,providing bothgroupswiththemostinterestingandinnovative technologiesavailable.

Attheendoftheday,it'saboutthepeopleandconnecting themwiththetoolstosucceed.Butaswemoveforward, thedefinitionsofsuccessarechanging,andthebreadthof technologiesavailabletousisreshapingourunderstanding ofwhatcanbedonetosolveproblemsweneverknew existed.Thisisprogress.

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Ōmcare

Whatisthebestthingtodoforyourselforyourlovedones whengoingthroughillness?

Theonlycorrectansweris CARE! Peoplearemost

comfortablewhentheyareintheirownplaceof comfort.Whenillnessoccurs,individuals'first instinctistoinstantlycheckitwithhealthcareprofessionals forproperdiagnosisandmedicalassistance.

Forvariousreasons,goingtohealthcareormedicalcare centreisnotalwaysaviableoption.Insuchasituation,a digitalhealthcaresolutioncanprovetobeagreatsighof relief.

Aremotedigitalcaresolutionprovidercompany,Ōmcare, cameintoexistencetoprovideeffectivehealthcareservices foryouandyourlovedonesfromthecomfortofyour home.

BasedinMinneapolis,Ōmcareisadigitalhealthcompany thataimstochangethewaytheworldcaresbyextending thereachofcaregivers,increasingmedicationadherence andimprovingtreatmentoutcomesthroughthepowerof remotecareandtwo-wayvideotechnology.Bypartnering withpharmacies,payers,providersandfamilycaregivers, Ōmcarestrivestohelppeoplelivehealthier,morevibrant, independentlivesandreducehealthcarecosts.

Dedicatedtoprovidingone-touchaccesstovarious healthcareneedsofthepeopleisŌmcare'sFounderand CEO,LisaLavin.

Let's dive into the story of Ōmcare in its ambitious journey to become an efficient remote care solution.

PromotingIndependenceandDignityforAgingAdults

Ōmcareisadigitalhealthcompanythathaspioneereda customizablehomehealthplatformthatenablesone-touch accesstotelehealthservices,aggregatedRPM,and medicationdispensingwithvisualconfirmationof medicationadherence.

Weallhavethoseextraspecialpeoplethatimpactusdeeply atsomepointinourlife.ForfounderLisaLavin,this specialpersonwashergrandmother,Mildred.Mildredwas Lisa'sprimarycaregiverduringadifficultperiodinher childhood.

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Ōmcare allows people to age in place, bringing humanity and liberation to the aging process. It also provides greater access to care to more people since it's less expensive and can reach rural areas.
Most Innovave Digital Therapeucs Companies

Lisa Lavin is a serial entrepreneur with over 25 years of experience building new businesses from the ground up within the healthcare and high-tech sectors. Lisa is active in local and national organizations that support entrepreneurialism and women in business.

Moreover, Lisa is a Minnesota Cup Division winner and Eureka Award winner for Innovation. She was recognized by Minneapolis / St. Paul Business Journal as one of 25 Women to Watch, Minnesota Business' Real Power 50, and The New York Observer's 2020 List of the Hottest "Flyover Tech" Companies in Digital Health.

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Lisa Lavin CEO Ōmcare

Lisaandhergrandmotherwereveryclose.AsMildred aged,shedevelopeddementiaandwaseventuallyplacedin anursinghomebecausetherewasnootherwaytohelpher maintainherindependence.

Throughthisexperience,Lisabecameimpassionednotonly forhergrandmotherbutforallagingadults.Lisavowed thatshewoulddoeverythingshecouldtopromote independenceanddignityforolderadults."This generation deserves much more than a nursing home,"saysLisa."They deserve connectedness, love, and a full, healthy, liberated life.”

All-in-oneHealthcareSolution

Homeisthenewsiteofcare,butitismessyandrequires manysolutionspiecedtogethertodaytowork.Andthe patientisalwaysinchargeofpiecingthemtogetherby themselves.

Forexample,ifyourmomhasatelehealthappointment. Hopefully,shehasatablet,andifshedoes,sheknows whereitis,andit'scharged.Thenifsheneedstotakeher bloodpressureorgivethedoctoranyothervitals,sheneeds totrackdownthosedevicestoo.Itsimplydoesn'twork.

Ōmcareopensupthehomeasalegitimatesiteofcareby creatingasingle,all-in-onesolutionthataddresses

Awards and Recognition

Ÿ 2020: New York Observer's Hottest Tech List (JP Morgan Conference)

Ÿ 2020: Named AARP Portfolio Company

Ÿ 2021: Named a finalist in the Accenture HealthTech Innovation Challenge

consumerexpectationswhileensuringthecomprehensive suiteofcapabilitiesrequiredforthehomeistogetherinan easy-to-use,one-touchinterface.Itbringseverything together—downtothedata.

GreaterReachandLowerCost

Theworld'shealthcareneedsareonaconstantrise.Getting customizedmedicalattentionfromtimetotimerequires peopletokeepvisitinghealthcarecentersfromtimetotime andalsopayhighamountsforsimpleconsultations.

Itisdifficultforolderadultstovisitdoctorsregularly The chancesofworseningtheirhealthcannotbeneglectedif theyhavetogotohospitalsonaregularbasis.Ōmcare

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Exhibiting Excellence

"Because my medications are packaged and I am on a schedule to have them dispensed, I don't have to think about them and remember to take them. " –Pilot participant

providessuchpeoplewiththego-tooptionforgettingonestopassistancefortheirhealthcareneeds.

"Ōmcare allows people to age in place, bringing humanity and liberation to the aging process. It also provides greater access to care to more people since it's less expensive and can reach rural areas,"saysLisa.

ReducingtheLoadonHealthcareSystemswith Technology

Imagininganyindustrywithoutatechnologysolutionis nearlyimpossibleincurrenttimes.Everyindustryhasbeen quicklyadoptingtechnologysolutions.However,itis importanttoensurethatwithtechnologyadditions,the processesaregettingstreamlinedandnotcomplicated.

Whenshediscussesaddingtechnologysolutionstothe healthcaresectorandproviders,Lisasays,"For technology to be beneficial, it has to work for both sides of the equation—the healthcare providers and the patients.”

Furthermore,shesays,"With this in mind, we've done rounds of the voice of consumer feedback, user testing, and, most importantly, made sure that non-clinical team members can handle our product.”

"That way, we use technology to lessen the burden on the healthcare system and providers, not add to it,"sheadded.

ShowingthePathtoEntrepreneurs

Anentrepreneurialpathrequiresonetoconstantlyassess thechallengesthatcouldcomeintheirway.Forknowing

moreaboutthechallengestobeexpectedandthepossible solutions,wordsofadvicefromexperiencedentrepreneurs, suchasLisa,canprovetobeanimportantpieceofcounsel.

Offeringheryearsofentrepreneurialwisdomtothe individualswhowishtocomeupwiththeirown technologicalventure,Lisatellsthemto"Design something you know will help so many people and get a good team around you. Both of those will make the bright days seem brighter and the hard days not as bad."

EnvisioningFuture

Withthehelpoftechnologyandadvancedhardware,the worldisgoingdigital.ThepathaheadforŌmcareisfilled withgreatpossibilities.Thecompanyplanstokeepon improvingitsexistingsolutionsandbringoutmore technologyproductstobestassisttheneedsofpatients remotely

Speakingaboutplansforthecompanyinthenearfuture, Lisasays,"By the end of 2022, we will be fully commercialized by rolling out the Ōmcare Home Health Hub® with senior care providers, pharmacy partners, and Medicare Advantage providers."

"It's the first of its kind. It's really innovative," - Brett Anderson, Ecumen Senior Care COO (pilot partner).
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For technology to be beneficial, it has to work for both sides of the equation—the healthcare providers and the patients.

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