INTEGRATIVE lifestyles TM
FALL 2019
BACK-TOSCHOOL STRATEGIES Help your kids ditch common classroom illnesses
THE ADHD EPIDEMIC PAGE 20
4
TOP SUPPLEMENTS FOR BREAST HEALTH
ANDROPAUSE ANGST?
MANAGE THOSE MANLY MIDLIFE SYMPTOMS
CIRCULATION
BASICS PAGE 12
COMPLIMENTARY ISSUE
VOLUME 4, ISSUE 0919
THE MOST CLINICALLY STUDIED ENHANCED ABSORPTION CURCUMIN IN THE WORLD!
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^ Based on enhanced absorption of CuraPro® curcumin versus equivalent weight capsule of unstandardized turmeric containing 2% curcumin. *THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THESE PRODUCTS ARE NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.
CuraPro
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contents
10
12
24
FEATURES
IN EVERY ISSUE
DEPARTMENTS
16 Manly Menopause The truth about andropause.
8 News
10
20 Natural
Solutions for ADHD
7 ways to help your child thrive.
You Can Use
Your Supplements
Keeping kids healthy this school year.
Roundup
12
IN DEPTH
Blood Flow Basics
24 Powerful
Prevention with Grape Seed Extract
Improve your circulation naturally. 30 ALTERNATIVE
Nature’s ultimate antioxidant.
4
It’s Back-to-School Bug Season
28 Decode
32 Research
HEALTH MAKEOVER
MEDICINE CHEST
Nature’s Breast Cancer Defenders
30
Key nutrients to keep you “in the pink.”
5
EDITOR'S CORNER It’s once again time to fall into Autumn and revel in all of the changes the season brings. But the turning leaves and cooler weather also signal back-to-school season, complete with the annual uptick in colds, flu, and other childhood illnesses. While these ailments may seem inevitable, it’s relatively easy to nip classroom germs in the bud with our all-natural, kid-friendly immune boosters. We’re also taking a serious look at the ADHD epidemic—a condition that affects 6.1 million kids under the age of 17. Check out page 20 for our non-drug strategies to improve mood, focus, and behavior. While this time of year seems to revolve around kids, we don’t want to forget the men in our lives—especially as they age. We’re breaking down all the myths surrounding male menopause and providing a host of natural ways to get back that youthful vitality! Another concern for both men and women? Blood flow. Flip to page 12 for the intel you can share with your patients on maintaining healthy circulation, from diet and lifestyle hacks to the three best supplements for healthy blood flow. We’re also including a special focus on a remarkable nutrient—French grape seed extract. Rich in antioxidants called OPCs, research shows that grape seed extract works in unique ways to help lower the risk of some cancers. And, since October is Breast Cancer Awareness Month, we’re rounding out this issue with the top nutrients (including French grape seed extract!) that can help foster better breast health. So take a few minutes away from your practice to put your feet up and enjoy some solitude with this issue of Integrative Lifestyles!
EDITOR-IN-CHIEF
Kim Erickson DESIGN/ART DIRECTOR
Roberta Jones DIGITAL CREATIVE DIRECTOR
Amy Medina ASSOCIATE EDITORS
Juanita Deterding Rami Jett Stan Daniels COPY EDITOR
Brandon DuVall CONTRIBUTING WRITERS
Michele Cagan Dr. Holly Lucille Dr. Ajay Goel EDITORIAL OFFICES
10040 W. Cheyenne Avenue Suite 170-161 Las Vegas, NV 89129 editorial@goodhealthlifestylesmag.com PUBLISHER
For general inquiries, email: info@goodhealthlifestylesmag.com
ViewALL ISSUES
Yours in health and happiness,
on www.Issuu.com
IL124_09_2019
Published by FreshLife Media, 10040 W. Cheyenne Avenue, Suite 170-161, Las Vegas, NV 89129. ©FreshLife Media. All rights reserved. No part of this publication may be reproduced without the written permission of the publisher. The opinions expressed by the contributors to Integrative Lifestyles are not necessarily those of the editor or publisher. The information in this publication is solely for educational purposes under Section 5 of the Dietary Supplement Health and Education Act of 1994 and is not intended as medical advice.
Kim Erickson EDITOR-IN-CHIEF
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ON YOUR TABLET
ON YOUR SMARTPHONE
ON YOUR COMPUTER
IN PRINT
7
NEWS YOU CAN USE GO NUTS FOR BETTER BRAIN FUNCTION
HFCS & U
Obesity continues to be a growing problem in the U.S.—a problem that can lead to a host of health issues, including an enhanced risk of developing colorectal cancer. One factor propelling the rise in obesity rates is the use of high-fructose corn syrup (HFCS). New findings show that a specific enzyme in tumors (ketohexokinase) converts HFCS into fructose-1-phosphate, a compound that works to modify tumor cell metabolism and increases tumor growth. Scientists suggest that continual consumption of modest amounts of HFCS can promote tumor growth, even in those who aren’t obese. This may explain why an increased intake of HFCS over the past few decades has corresponded with elevated rates of colorectal cancer in the U.S. Goncalves MD. High-fructose corn syrup enhances intestinal tumor growth in mice. Science. 22 Mar 2019: Vol. 363, Issue 6433, pp. 1345-1349. DOI: 10.1126/science.aat8515.
Going nuts for nuts could be the answer for better cognitive health in older people. According to a new study from the University of South Australia, eating 10 grams (about a hefty handful) of nuts each day was positively correlated with enhanced mental capacity, including improved thinking, reasoning, and memory. The research published in The Journal of Nutrition, Health & Aging suggests that older adults could elevate their cognitive function by up to 60 percent, compared to those not eating nuts—a welcome sign for those prone to diseases like Alzheimer’s. Not only can nuts boost brain performance, they are also packed with healthy fats, protein, and fiber, making them the perfect snack to keep you healthy and satiated. Ming L. A Prospective Association of Nut Consumption with Cognitive Function in Chinese Adults Aged 55+, China Health and Nutrition Survey. The Journal of Nutrition, Health & Aging. Feb. 2019, Vol. 23, Issue 2, pp 211–216.
28.2 million
THE NUMBER OF ADULTS LIVING WITH DIAGNOSED
HEART DISEASE.
National Center for Health Statistics. Summary Health Statistics Tables for U.S. Adults: National Health Interview Survey, 2017, Table A-1b, A-1c.
♥ MAGNESIUM
Most Americans aren’t getting enough magnesium—and that’s a problem since individuals with intakes below the recommended daily allowance are 40 percent more likely to have elevated C-reactive protein (CRP) levels than people getting enough of this vital mineral. Researchers at the Medical University of South Carolina have found that CRP can trigger acute inflammation, which is a significant risk factor for heart disease. The good news is that this research also shows it doesn’t seem to matter if your magnesium comes from natural food sources like spinach, tuna, nuts, and seeds, or from supplements. If you do supplement, look for the glycinate form of the mineral to maximize absorption and minimize gastrointestinal issues. King DE. Dietary magnesium and C-reactive protein levels. J Am Coll Nutr. 2005 Jun;24(3):166-71. 8
A PURR-FECT SOLUTION FOR
HEALTHY AGING
While exercise and a balanced diet are vital for healthy aging, owning a pet can be just as important to good health later in life. According to new data from the National Poll on Healthy Aging, more than three-quarters of pet owners aged 50 to 80 said their animals reduce stress and two-thirds said their pets help them be physically active. Even more impressive was that for individuals who described their health as fair or poor, owning a pet seemed to provide greater benefits. Over 70 percent of these older adults claimed that their pet helps them manage physical or emotional symptoms—and 46 percent said their pets help take their mind off of pain. Janevic M. How pets contribute to healthy aging. University of Michigan National Poll on Healthy Aging. April 2019. http://hdl.handle.net/2027.42/148428.
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IT’S BACKTO-SCHOOL
bug on seas
How to dodge the sniffles, sneezes, coughs, and colds by Michele Cagan Back to school often means a trip back to the doctor for kids and their parents. Your little germ magnets get exposed to coughs, colds, sore throats, and sniffles. They trade viruses faster than Pokémon cards, so ailments spread swiftly through the young crowd. Kids rarely make the hand washing all-star team, they stick toys in their mouths, and they often share food. In that spirit of sharing, they bring infections home for the whole family. What’s more, since there are hundreds of different cold viruses, it’s impossible to build 10
up complete immunity. That’s why kids suffer an average of six colds every school year. If you’re lucky, you might be able to avoid one or two. But chances are, whatever your child brings home will land on you as well. And even if you don’t catch it, if your child is too ill to go to school, you’ll probably have to take a sick day too. The season’s circulating viruses bring on the three most common backto-school complaints: colds, sore throat, and earaches. In the best-case scenario, your child won’t get sick at all or the illness will only knock them out for a day or two. You can make those the most likely outcomes by taking a preventive approach. To do that, you need to know exactly what you’re up against.
BUGS TO BEAT Colds— officially called rhinoviruses—rank among the most contagious ailments on Earth, especially in the classroom. Marked by runny noses, soggy sneezes, and copious coughing, colds spread easily and quickly. Symptoms usually appear within two days after infection. Most of the time, colds disappear after a week or so with no trip to the pediatrician necessary. Sometimes, though, they can evolve into more serious infections (like bronchitis, for example), calling for a doctor visit. Sore throat comes from a variety of sources, from common colds to post-nasal drip to the super dry air in heated rooms. Sometimes though, streptococcal pharyngitis—the dreaded “strep throat”—makes the rounds. How can you tell the difference? Strep
throat often comes with a high fever, painful swallowing, and nausea. The strep bug may call for a round of antibiotics. Earaches often grow out of colds, but sometimes they just crop up out of nowhere. Otitis media (the official moniker for an earache) can be shockingly painful and may come with a fever. And while antibiotics used to be the go-to treatment, that’s no longer the standard except for the most severe cases. With all of these illnesses working against you, it can be a challenge to keep your family healthy once school starts up.
CHALLENGE ACCEPTED Arm yourself with a natural “antiviral first aid kit” so you and your kids can sidestep most of the viruses floating around. And if you do succumb, you’ll have milder symptoms and get better faster. For complete protection against backto-school germs, stock your kit with these three thoroughly researched and Dr. Momapproved remedies.
andrographis:
You may have never heard of andrographis, but you’ll fall in love with it during cold and flu season. Several clinical studies have clearly demonstrated its cold-fighting powers. Andrographis can prevent the common cold from taking hold—even in kids who are constantly exposed. When cold symptoms do show up, andrographis helps banish them in no time flat. Studies show that it reduces symptom intensity (especially runny noses and sore throats) in just two days, and dramatically decreases even the worst
symptoms (like earaches and coughing) by day three. For best results, look for a standardized andrographis supplement that contains at least 80 mg of andrographolides, the key virus-killing compound. For preventing colds and other infections, take 400 to 1,200 mg of standardized andrographis every day, starting about three weeks before the kids are back in school.
“controlled” environments, where hives are placed strategically near the most beneficial plants. Look for propolis that’s standardized, purified, and clear of beeswax.
probiotics:
Believe it or not, your digestive tract holds nearly 70 percent of your
propolis:
“Bee glue” may sound weird, but it’s one of the most protective substances in the world. Propolis— a.k.a. bee glue—coats, seals, and strengthens beehives. More important, it protects the bees inside against every invader imaginable, including bacteria, viruses, and fungi. Propolis also offers a broad-spectrum shield against a wide variety of infectious microbes in humans. That includes the bacteria that cause strep throat, flu viruses, and cold viruses. It can even kill off drug-resistant superbugs! Studies show that propolis (especially when combined with zinc) can reduce the frequency of ear infections, fight the flu, ward off colds, and shorten their duration. Packed with protective bioflavonoids, antioxidants, and nutrients, propolis contains everything you need to thwart whatever germs the classroom sends your way. To maximize these benefits, most experts recommend a daily dose of 100 to 200 mg. Use care in choosing a propolis extract, though. The best extracts come from
immune system. That’s why a healthy gut is your number one ally in the fight against back-to-school germs. Good bacteria (probiotics) strengthen and support your immune system, but things go awry when bad bacteria take over. Many things can contribute to an imbalance including antibiotics, poor diet, and stress. The good news: You can restore good bacteria with a probiotic supplement. The bad news: Most probiotics sold on store shelves won’t deliver the beneficial bacteria you need. To get the best result, you’ll need at least 20 billion live, active probiotic bacteria in every dose. For full immune system support—and the ability to fight infections before they strike—look for proven probiotic strains such as Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium bifidum.
Michele Cagan is a natural health writer. She loves digging through the latest research on herbs and nutrients to track down the most effective, natural ways to manage common health issues. 11
IN DEPTH
BLOOD FLOW BASICS Ways to improve circulation naturally!
U in your fingers or toes—or nless you have numbness
wounds that seem to take forever to heal —you probably don’t give your circulatory system a lot of thought. Yet the blood that flows through the highways and byways of your circulatory system provides the billions of cells throughout your body with the oxygen and the nutrients they need to function. Poor circulation can rob your muscles and organs of these critical nutrients. Of more concern, poor circulation can be a precursor to a heart attack, stroke, or even amputation. How do you know if you’ve got sluggish circulation? Some of the obvious signs include pain and swelling in the hips or legs, tiredness, numbness, cold hands and feet, or cramping or tingling in the fingers and toes. The cause can be something as simple as your lifestyle choices or the number of birthdays you’ve celebrated. But, while there are some risk
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factors like age that you can’t control, there are a number of things you can do to get your blood flowing again!
BE ARTERY SMART
If you’ve got a clogged pipe in your kitchen or bathroom, any plumber will tell you that it can eventually affect every room in the house. The same is true for your circulatory system—that complex network of arteries, veins, and capillaries that transport oxygen-rich blood throughout your entire body. Anything that impedes the free flow of blood can eventually impact other bodily systems. Certain medical conditions can damage your arteries and reduce blood flow. Oxidized LDL (“bad”) cholesterol can contribute to the buildup of arterial plaque. High blood pressure can injure the lining of your arteries, technically known as the endothelium. This too can leave you vulnerable
for the accumulation of plaque that can slow the flow of blood. Another factor that can injure the endothelium is diabetes. Uncontrolled blood sugar not only encourages inflammation, it increases triglycerides and decreases “good” HDL cholesterol—all factors that can impact circulation. Your habits and lifestyle choices matter. Cigarette smoking contributes to poor circulation by constricting blood vessels. Over time, this injures the smooth endothelial lining and can lead to reduced blood flow. A sedentary lifestyle promotes sluggish blood flow. If you spend your
13
days sitting behind a desk or in a car, it’s important to move your body periodically and adopt a regular exercise routine. What you eat is also key. A diet filled with unhealthy fats and refined foods can lead to impaired circulation. Even one unhealthy meal can slow the flow of blood through your arteries, say Canadian researchers at the University of Calgary. Their research, which was presented at the 2012 Canadian Cardiovascular Congress, proved that just one highfat, fast food meal can reduce blood flow by as much as 20 percent—a reduction that can take up to 24 hours to normalize. Instead, focus on whole foods, including fiber-rich fruits and vegetables, healthy fats like olive oil or nuts and seeds, and lean protein.
vitamin C and vitamin E or betacarotene. In an eight-week study of healthy postmenopausal women, grape seed extract effectively enhanced blood flow. Another study found that the OPCs in grape seed extract reduced leg swelling and edema (both signs of poor circulation) by an impressive 40 percent among young women after six hours of sitting. Yet, most grape seed extracts have a high molecular weight and contain tannins that can interfere with absorption. Look for a tannin-free supplement that contains VX1 French grape seed extract to ensure a low molecular weight for optimal absorption.
Omega-3s
CIRCULATORY SUPPLEMENTS
While adopting a healthy diet and exercise program can foster better circulation, adding the following nutrients to your daily regimen can help protect your circulatory system even as you age. This is especially important if you’re already at an increased risk of heart disease.
French Grape Seed Extract
The secret to grape seed’s blood flow benefits comes from oligomeric proanthocyanidin complexes (OPCs), powerful antioxidants that also boast anti-inflammatory properties. Studies show that the OPCs in French grape seed extract are better free radical fighters than a combination of either 14
Mesoglycan
This compound is naturally found in the lining of blood vessels. When taken in supplemental form, it provides glycosaminoglycans (GAGs)—vital and necessary components of the endothelial cells that line healthy blood vessels and keep them flexible. As a result, blood vessels are stronger, which helps maintain healthy blood flow. In an Italian clinical study of patients with heart disease, mesoglycan showed healthy anti-clotting activity after just one dose. A similar clinical trial of patients with atherosclerosis published in the journal Current Therapeutic Research showed improved blood flow in just 30 days. In another Italian placebo-controlled study of 64 diabetic patients with peripheral artery disease, those taking mesoglycan experienced an improvement in pain-free walking and improved endothelial function, suggesting significantly better blood flow to the legs.
Found in cold-water, fatty fish like salmon, omega-3s are especially beneficial for healthy circulation. The key omega-3 fatty acids in fish— DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid)—improve blood lipid profiles, reduce inflammatory markers, and help build strong, flexible arteries and blood vessels, all factors that improve circulation. One Dutch study found that omega3s enhance circulation in the brain while also providing other brain-boosting benefits. An earlier study conducted at the University of California, Davis, reported that supplementing with omega-3s significantly enhanced brachial artery dilation and blood flow compared to a placebo. Fortunately, you don’t need to take massive doses or oil-filled capsules to reap these circulatory benefits. For a more convenient choice, look for an omega-3 supplement created from salmon that is bound to phospholipids so you only need to take one tablet or capsule daily.
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Manly MENopause? The truth about andropause by Kim Erickson
H
ave you been feeling a little hot under the collar lately, but seldom under the sheets? Is your midsection getting softer by the day? Are your mood swings and night sweats enough to drive your partner to the couch? I know what you’re thinking: It must be menopause. But wait a minute, you’re a man! Could you also be in for a “change of life?” ANDRO WHAT? Although male menopause has historically been brushed aside as myth, recent studies are giving the condition credibility. Here’s what you need to know: Scientists have long known that a man’s testosterone level begins a slow downhill slide as early as age 30, dropping about one percent a year after the age of 50. Add that to the fact that other sex hormones and brain chemicals also begin to fluctuate, and middle-aged men can quite possibly look
16
forward to an array of andropause symptoms, including a loss of muscle mass, fatigue, depression, loss of libido, erectile dysfunction (ED), and even hot flashes. But not having enough testosterone can also increase your risk of some life-threatening conditions such as cardiovascular disease, cognitive decline, obesity, and type 2 diabetes. THE T FACTOR Testosterone is made in the testes and it’s the most important reproductive hormone in men. In fact, it’s the hormone responsible for that deep voice, those burly muscles, and your cool hipster beard. This super-hormone also supports healthy bones, muscle mass, and red blood cell production. It even dictates where body fat is stored. If you suspect your levels are low, get checked. Initially, your doctor will measure your total testosterone using a simple blood test. Normal levels fall between 300-1,000 ng/ dl. A reading below 250 indicates low testosterone levels. Other tests may also be conducted to measure the amount of free testosterone and another hormone called dehydroepiandrosterone (DHEA)—a hormone produced by the adrenals that serves as a precursor to testosterone. UNDER THE HOOD One of the most frustrating side effects of low testosterone levels can often be found in the bedroom. Testosterone is central to a man’s sexual response, including the mechanics of triggering an erection. In fact, testosterone modulates nearly every step involved in gaining and maintaining an erection, from the nerves in the pelvis to the smooth muscle and endothelial cells
of the corpora cavernosa. This heman hormone also regulates sexual desire and the timing of the erectile process. Low testosterone levels can undermine performance and interfere with intimacy. But that’s not all. Erectile dysfunction can actually be one of the first indicators that you may have cardiovascular disease. Researchers at the University of Sheffield, U.K. have linked low testosterone to an uptick in atherosclerosis, hypertension, heart failure, and heart attack. This is because low testosterone levels are connected to insulin resistance, obesity, and diabetes. Each of these factors boosts the risk of cardiovascular disease. SMARTER CHOICES For men hitting midlife, it’s often time for a diet and exercise tune-up. Whole unprocessed
3
WAYS TO INSTANTLY RAISE YOUR
T
1.
foods are the way to go when planning your diet. Focus on low-sugar fruits and non-starchy vegetables, as well as lean meats, fish high in omega-3 fatty acids, and healthy fats like avocados or extra virgin olive oil. Steer clear of, or at least minimize, added sugars and carbohydrates. And since andropause can trigger weight gain, watch your portion size and try to refrain from snacking. Exercise matters too. Since there is a direct relationship between muscle mass and testosterone, you can raise your testosterone levels by getting into a weight-lifting program. Studies show that as few as two sessions of strength training per week can increase muscle strength by more than 30 percent while also boosting bone density, speeding up metabolism, and pushing up production of testosterone and other sex hormones. Exercises that target several large muscle groups (like squats or bench presses) boost testosterone levels more than those that
Get enough sleep.
Men produce most of their daily testosterone when they sleep. Set a regular bedtime and wake time, and watch the amount of caffeine you consume. If sleep apnea is a problem, have it treated.
2.
Drink moderately.
Alcohol has been shown to lower testosterone levels and inhibit the release of nitric oxide. Limit yourself to no more than two drinks per day.
train isolated muscles (like curls). Just don’t overdo it, especially if you are on a weight-loss diet. Over-training and under-eating can also wreak havoc on testosterone production. SUPPLEMENT THIS! Maca is a Peruvian herb said to boost endurance, stamina, and sexual virility. It’s used by both men and women to stimulate both libido and pelvic blood flow. But does it work? A 12-week double-blind, placebo-controlled study found that healthy men who took the herb did indeed have an increase in desire. Earlier animal studies have found that maca also increases stamina and semen quality. The key to maca’s effectiveness are glucosinolates, natural plant compounds that help balance hormone levels, particularly testosterone.
3.
Break a sweat.
Exercise naturally increases testosterone levels. Strive to get at least 30 minutes of exercise daily. Doing what you enjoy, whether it’s walking, weightlifting, playing sports, or riding a bike, can help you stick with it. As a bonus, exercise effectively lowers stress levels and improves mood.
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According to clinical trials, this compound not only aids men suffering from erectile dysfunction, it can also help healthy people who simply want to increase their libido. Research in the journal Urology shows that glucosinolates help to decrease the amount of time it takes to achieve and maintain an erection. For best results, seek out a supplement that provides a 4:1 extract of the maca root. French Grape Seed Extract is rich in oligomeric proanthocyanidin complexes (OPCs) that provide powerful antioxidant and anti-inflammatory benefits. OPCs also inhibit an enzyme called aromatase that converts testosterone to estrogen. But grape seed extract works on numerous fronts to support good health in the midst of andropause. Studies show that the OPCs in grape seed extract increase adiponectin, a protein that regulates blood sugar, insulin, cholesterol, and inflammation, by an impressive 61 percent. One study by Dutch researchers also reports that grape seed extract can reduce the amount of calories you consume. And Spanish scientists note that, in addition to reducing food intake, the OPCs in grape seed extract specifically target belly fat—a boon for any guy looking to lose weight. Grape seed extract OPCs have also been found to protect against age-related cognitive decline, and enhance memory and focus. It does this by preventing oxidative damage and inflammation that can cause structural changes to the brain as you age. But not all grape seed extracts deliver these results. Look for a tannin-free grape seed extract that provides low molecular weight OPCs to ensure that the molecules in the supplement are small enough to be absorbed and utilized by the body. Omega-3s protect blood vessels thanks to two fatty acids, 18
docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Numerous studies show that these two omega-3s help reduce high blood pressure and triglyceride levels. They modulate many of the mechanisms of atherosclerosis, including inflammation, blood clotting, and platelet aggregation (stickiness). But you needn’t take fish oil long-term before experiencing benefits. Omega-3s can bring immediate aid to your arteries. According to a 2010 trial at the University of Illinois, Urbana-Champaign, when 20 volunteers were fed a high-fat meal designed to dampen endothelial function and boost arterial stiffness, those who took 1,000 mg of fish oil after eating appeared to be protected against the dietary-induced damage. Of course, this doesn’t give you an excuse to dive into a greasy burger and fries. It’s simply an example of the protective properties fish oil has on your circulatory system.
IF performance is top of mind when it comes to andropause, red ginseng may help reignite your passion and improve your capabilities.
But the benefits of omega-3s don’t stop there. These healthy fats also increase free testosterone by decreasing levels of sex hormone binding globulin (SHBG), improving testicular function, and may even enhance sperm quality. To truly reap all of the healthy advantages omega-3 fatty acids have to offer, it’s smart to add
an EPA/DHA supplement sourced from salmon to your routine every day. Red Ginseng If performance is top of mind when it comes to andropause, a unique, highly concentrated, hydroponically grown red ginseng known as HRG80 may help reignite your passion and improve your capabilities. In one double-blind, placebo-controlled study of 45 men with ED, 60 percent of those who took red ginseng for eight weeks reported improvement in their symptoms compared to those taking a placebo. In a review of 28 studies of the herb’s efficacy that appeared in the British Journal of Clinical Pharmacolog y, researchers concluded that red ginseng has hormonal effects similar to testosterone and may relax the smooth muscles of the corpus cavernosa. Red ginseng has also been found to support a healthy cardiovascular system. A double-blind, randomized, placebo-controlled clinical trial published in the journal Cardiovascular Therapies found that red ginseng significantly improved flow-mediated vasodilation, which expands arteries in response to blood flow. This, in turn, improves how well the inner lining (the endothelium) of arteries functions. Another trial that appeared in the journal Complementary Therapies in Medicine reported a significant improvement in diastolic blood pressure (the bottom number), the stress hormone cortisol, and mitochondrial function. Bonus: The researchers also noted a boost in total testosterone! Kim Erickson is a respected health and medical writer, and the editor-in-chief of Good Health Lifestyles. In addition, she is the author of Drop Dead Gorgeous: Protecting Yourself from the Hidden Dangers of Cosmetics and the co-author of Living Lessons: My Journey of Faith, Love, and Cutting-Edge Cancer Therapy.
NATURAL
Solutions
for
ADHD
by Holly Lucille, ND, RN
A
dding up the numbers can stop you in your tracks. According to the Centers for Disease Control (CDC), 6.1 million children between the ages of 2 and 17 are diagnosed with attention-deficit/ hyperactivity disorder, or ADHD. Marked by an inability to focus or pay attention, and a pattern of acting impulsively, 6 out of 10 (62 percent) of them take medication for the disorder. That represents 1 out of 20 kids in the US! In up to 60 percent of these cases, this neurobehavioral disorder continues into adulthood and it’s often undiagnosed or misdiagnosed. To further complicate the diagnosis, not all ADHD is the same.
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e e ma i n r h t e r a e T her es of ADHD: c at e g o r i T LY OMINA N 1 . P RE D CT I VE / HYP E RA VE IMP UL SI
ARILY 2. P RIM NTIVE – INAT T E cus and lack of fo without attention ity iv hyperact
ION – BINAT of M O C 3. ition The exhib ion and t inatten ity impulsiv
Getting a proper diagnosis of the type of ADHD, as well as understanding all the options for treatment, can save children and adults from low self-esteem, social problems, and an inferior quality of life. For those who think that synthetic drugs are the only solution, there is good news. Effective nutritional solutions for ADHD can help both children and adults with ADHD.
NOURISHMENT MATTERS
Since ADHD is a neurobehavioral disorder, it makes sense to rely on brain-healthy foods for better focus and stamina. It’s well documented that sugary substances lead to cravings for more sugar and a “sugar high” that leads to greater impulsivity even in someone not challenged with the disorder. A high-protein, low-sugar diet free from food additives like artificial colors and flavors can help manage symptoms. Beans, lean organic meat, organic eggs, and nuts are all good protein sources. Skip or try to limit any sugar-based foods including those with hidden sugars from things like corn syrup. Another hidden trigger is food additives, many of which are banned in Europe. A partial list of artificial colors linked to ADHD includes Blue #1 and #2 food coloring, as well as Green #3, Orange B, Red #3 and #40, and Yellow #5 and #6. Pay close attention to food labels and avoid these additives—a task that is easier to do if you stick to whole and fresh foods. Also, eliminate “white” foods, as in white flour and white rice—stick to whole grains instead.
GO FISH!
Since omega-3 fatty acids are essential for someone dealing with ADHD, the answer for this nutritional component may seem simple: Eat fish. Yet most people don’t eat enough fish, or enough of the right types of fish, to get results. Research shows that the health benefits from fish come from two specific omega-3 fatty
acids—eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Since fish often doesn’t make a regular appearance on the dinner table, many people turn to fish and krill oil supplements to get these two vital fats. The problem is, most fish oils are processed using heat and chemical solvents which make the fatty acids less absorbable and bioavailable to cells. What has been shown to be superior is DHA from the head of Atlantic salmon and obtained using a unique enzyme and cold-water extraction. This type of processing provides natural DHA and EPA in a form the body can use. It also gives the bonus of health-promoting phospholipids and peptides in addition to the omega-3s. This approach to obtaining omega3s allows someone with ADHD to reap the benefits of the omega fatty acids without the worries of heavy metals, rancidity, and even fishy burps that often accompany other types of fish and krill oil supplements. How well do omega-3s work for kids with ADHD? One Dutch study found that higher blood levels of DHA correlated with better spelling and reading scores. Another clinical study involving 8- to 10-year-old boys showed that DHA supplementation improved attention span and may have helped play a role in rewriting cortical attention networks in the brain in just eight weeks. And 7- to 9-year-olds showed improved reading scores after DHA supplementation. Parents also noted better overall behavior. With these impressive findings, it makes sense to introduce
omega-3s into a child’s regimen as early as possible.
MORE SUPPLEMENTS THAT SHINE
There are a multitude of botanicals that deliver when it comes to ADHD. Consider adding one or more of the following to your child’s daily routine:
Saffron and Curcumin The first is saffron, a spice that many people know because of the unique flavor it adds to food. In a six-week randomized, double-blind study, children between the ages of 6 and 17 were given either a synthetic drug most often prescribed for ADHD or 20 to 30 milligrams of a saffron supplement. The treatments worked equally well as rated by the Teacher and Parent ADHD Rating Scale. Children taking the saffron received the same benefit and skipped the side effects associated with the drug. Adding a highly absorbable form of curcumin such as BCM-
95 (Curcugreen) enhances saffron’s antidepressant and neuroprotective benefits in those with ADHD. Echinacea While most people equate echinacea with immunity, this herb also contains a unique compound that influences brain chemistry and can reduce the anxiety common in those with ADHD. This novel form of echinacea (Echinacea angustifolia) utilizes a specialized extract of the plant that
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contains phytonutrients shown to support brain receptors associated with feelings of relaxation. Taking this herb in a tablet form, which contains the clinically studied, unique extract of Echinacea angustifolia called EP107, can spare the drowsiness and common side effects that go with anti-anxiety medications. One study showed that when it was given to participants experiencing anxiety, there was a decrease in their measurable anxiety levels. These benefits not only lasted during the remainder of the seven-day trial, they persisted for the following two weeks—and none of the children experienced side effects. Adaptogens Rhodiola and Ashwagandha Rhodiola has been clinically shown to boost focus and concentration, promote resilience, and reduce fatigue under a variety of circumstances. Who has a more hectic schedule than physicians on the night shift? A well-known clinical study showed that even under these circumstances, rhodiola improved total mental performance. From test-taking to help in reducing feelings of stress, anxiety, and depression, rhodiola appears to have a direct, positive action on brain chemistry and the way it affects focus and mood. Another adaptogen that has a positive effect on brain chemistry is ashwagandha. Extensive research has proven its ability to help stabilize the body’s response to stress, improve focus, and reduce anxiety without side effects. Combining rhodiola and ashwagandha in a synergistic formula helps support the stresses caused by ADHD. French Grape Seed and Pine Bark Focus and concentration can be a real problem for people with ADHD. An absorbable French grape seed extract that contains small molecular weight oligomeric proanthocyanidins (OPCs) has been scientifically shown to provide 22
What are some SIGNS of
ADHD?
Diagnosis is a process as there is no single test to determine ADHD. Children or adults receive an ADHD diagnosis when they show six or more symptoms in at least two settings over six months. If you suspect you or your child suffers from ADHD, work with a qualified health professional. Examples of ADHD symptoms include: • Constantly in motion • Squirms and fidgets • Doesn’t seem to listen when spoken to directly • Difficulty finishing tasks • Often interrupts or intrudes on others • Easily distracted • Excessive talking • Avoids tasks that require sustained mental effort
results. With anti-inflammatory and antioxidant actions that preserve glutathione and other natural compounds in the brain and nervous system, grape seed extract is a winning answer for ADHD. In a placebo-controlled, doubleblind study published in the European Child & Adolescent Psycholog y, OPCs boosted attention span and caused a noticeable reduction in hyperactivity after just one month. But with known adulteration of cheap ingredients like peanut skins in some grape seed supplements, and large OPC molecules that can’t be absorbed by the body, it’s imperative to choose a tannin-free, low molecular weight supplement like French grape seed VX1. Next, consider adding a pine bark extract. In a placebocontrolled, doubleblind study, children were evaluated using a series of rating scales and basic psychiatric examinations. After one month, the researchers found that the children assigned the pine bark extract showed improved attention and a 20 percent decrease in hyperactivity while those assigned the placebo showed no improvement in behavior.
NATURAL ALTERNATIVES ABOUND
With many parents adverse to the stimulant medications commonly prescribed for ADHD, turning to a healthy diet combined with herbal nutrients to improve focus and attention is a welcome alternative. Understanding all the options available, plus knowing how to assess the effectiveness of what herbs and nutrients to look for brings welcome, healthy choices for anyone experiencing ADHD. Holly Lucille, ND, RN, is an author, educator, and television and radio show host with a medical practice in California. An acclaimed expert in the field of integrative medicine, Dr. Lucille has a heartfelt passion for the individual wellness of all people. Visit her website at drhollylucille.com.
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POWERFUL PREVENTION with
Grape Seed Extract Nature’s answer to free-radical damage by Ajay Goel, PhD
C
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urrent statistics on cancer are staggering. According to the American Cancer Society, more than 4,800 new cases of cancer will be identified each day in 2019. The chance of a person being diagnosed in their lifetime is now 1 in 3. The questions beg to be asked: Why is this devastating disease so widespread? And is there any hope for prevention?
Research shows that cancer can be attributed to a number of causes, but pinpointing a reason you or a family member may have developed the disease is nearly impossible. Tobacco use, toxic chemicals, obesity, hormone imbalances, radiation, viruses, chronic inflammation, and lack of exercise can all set the stage for the cellular damage that leads to cancer. An extremely complex disease, cancer doesn’t come with a one-size-fits-all cause—or solution. GOOD CELLS BEHAVING BADLY
All cancers can be traced back to an abnormal functioning of cells in the body. Ideally, each of your cells divides in an orderly fashion. During the typical life cycle, old or damaged cells die (a process known as apoptosis) and healthy new cells take their place. Cancer develops when the damaged cells don’t die, but continue to divide and grow. This overgrowth of damaged cells can eventually form tumors that may spread to other organs and tissues. But take heart—along with the sobering statistics on cancer comes some good news. For many years doctors believed that cancer was primarily a hereditary disease. Now we know that more than 95 percent of cancers have little to do with your genes, but may be contributed to certain lifestyle and environmental factors. Why is this considered good news? While it can be nearly impossible to control things like toxins in the environment, it is possible to control some of the lifestyle factors that could lower your cancer risk in the first place. Also, treatment options are advancing. Screening techniques are becoming more effective. Best of all, cancer survival rates are on the rise. So while
cancer remains extremely prevalent, people are beating it more than ever before in history. In the case of such a devastating illness, these small victories are cause for celebration. Another major contributor in the fight against cancer is the fact that people are becoming more educated in the many ways they can proactively help to prevent the disease in their own lives. While eating a healthy diet, participating in regular exercise, and avoiding tobacco products can provide a good start, science now tells us there are some powerful natural compounds that may have the ability to lessen the odds that the disease ever takes hold. One of the most effective weapons to have in your cancer prevention protocol is grape seed extract. AMAZING ANTIOXIDANT POWER
Grapes are abundantly rich in diseasefighting nutrients, including antioxidants that protect your cells from oxidative stress and inflammation. The skins and seeds of the grape contain high antioxidant concentrations that can benefit a number of health conditions, including heart disease, diabetes, and cancer. When it comes to disease-fighting botanicals, few have proven to be as powerful and versatile as grape seed extract. Grape seed extract is so potent because it contains oligomeric proanthocyanidins, or OPCs. OPCs are compounds with great protective value, but to be beneficial, their molecular structure needs to be tiny and readily absorbable. The best OPCs are found in a French variety of grape seed extract called VX1. VX1 is tannin-free and has unique specifications that make it highly absorbable—and therefore more effective—in the body.
STUDIES ON THE RISE
Impressively, French grape seed extract VX1 has a growing body of research backing its powerful cancerprevention abilities. In a number of studies, OPCs have been shown to inhibit cancer cell proliferation and trigger cell death in colon, breast, prostate, and other cancers. They have also been shown to shrink the size of tumors, as well as target cancer stem cells that have become resistant to chemotherapy. One study appearing in the journal Carcinogenesis focused on colorectal cancer, one of the most deadly cancers in the United States. The research found that VX1 was able to boost levels of tumor-fighting genes, “turn off” the genes that promote tumor growth, and prevent the spread of cancer cells. And when compared to other grape seed extracts in the study, VX1 was significantly more effective at a much lower dose than standard extracts. It’s also important to note that no healthy cells were harmed in this study. The OPCs pinpointed the cancer cells without destroying any healthy tissue. TARGETING STEM CELLS
Another impressive study shows the effectiveness of OPCs on cancer stem cells. You’ve heard it time and again. Someone is declared to be in remission or “cancer free,” only to have a reoccurrence in the future. Why does this happen? Because cancer cells are smart and resilient. Sometimes they can hide in the body and become resistant to chemotherapy treatment.
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Mor e POWERHOUSE PROTECTION Curcumin
This extremely potent antioxidant is the darling of the natural medicine world when it comes to inflammatory defense. Known for its unparalleled ability to stop the freeradical cascades in the body that can lead to inflammation, curcumin also has the ability to enhance the beneficial effects of chemotherapy. BCM-95 curcumin (a proprietary ingredient also known as Curcugreen) is the subject of over 50 published studies for its medicinal benefits. Preliminary research on its anticarcinogenic activity has found that it can suppress breast, prostate, liver, skin, oral, colon, and lung cancer cells. One study in particular researched the benefits of BCM95 curcumin when combined with French grape seed extract VX1. Because these two botanicals target separate inflammatory pathways in the body, taking them simultaneously may pack an even bigger punch than taking either of them alone.
While chemotherapy can cause cancer stem cells to become chemoresistant, the OPCs in French grape seed extract VX1 target a unique pathway called HippoYAP that is necessary for stem cell survival. After exposing colon cancer cells to this standardized extract, tumor growth was suppressed by as much as 90 percent.
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While grape seed extract has a great deal of anticancer properties, studies show that the following vitamins and botanicals can also set the stage for cells to exist cancer-free.
Boswellia
Another of nature’s powerful antiinflammatory botanicals, boswellia stands out for its unique ability to target numerous inflammation pathways in the body, including an important one called 5-LOX. Not even curcumin and grape seed extract can touch 5-LOX, which is thought to contribute to serious health conditions like arthritis, Alzheimer’s, and inflammatory bowel disease. In a cell study performed in Egypt, boswellia was found to be comparable to two chemotherapy drugs for inhibiting the growth of colon and liver cancer cells. Other preliminary work has shown that a primary compound in boswellia called AKBA was able to stop the growth of leukemia and prostate cancer cells by making the cancer cells unable to form blood vessels—their source of survival. When looking for an effective boswellia product, check the label to make sure it is standardized to 10 percent AKBA.
Additional findings published in Carcinogenesis reported that VX1 can stop DNA from replicating itself, which prevents the spread of cancer. ADULTERATION AWARENESS
To get the most cancer-prevention potential from a grape seed extract supplement, look for French grape seed extract that is tannin-free with small OPCs for proven absorption. The best products have gone through
Vitamin D
Yes, the “sunshine vitamin” can do much more than keep your spirits up. Studies show it may prevent or slow the growth of some types of cancers, including breast, prostate, colon, and even pancreatic cancer. Vitamin D is unique in the way that it acts like a hormone in the body, helping to build healthy bones and regulate immune, muscle, and nervous system function. While the full benefits of vitamin D on cancer prevention still need to be explored, preliminary findings are promising. A recent study in PLOS ONE showed that postmenopausal women with higher amounts of vitamin D in their blood had a significantly lower risk of developing breast cancer than those with lower vitamin D counts. More research reflects that vitamin D has an influence on tumor growth and apoptosis. Remember that before you up your vitamin D intake, it’s important to get a blood test through your healthcare provider to check your levels.
a verification program to determine that the extract is authentic and hasn’t been adulterated. Ajay Goel, PhD, is a Professor and Chair, Department of Translational Genomics and Oncology at the Beckman Research Institute City of Hope Comprehensive Cancer Center, as well as Director of Biotech Innovations at the City of Hope Medical Center. He has been recognized as an American Gastrointestinal Association Fellow (AGAF) for his research on colorectal cancer.
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D E C O D E YO U R S U P P L E ME NTS
n: Vitami
When it comes to supplements, patients have questions—lots of them! Here is a codebook for three of the most widely used and most important natural ingredients that can confuse consumers. Share it with your patients to help them make better informed choices.
l: Minera
WHAT IT IS:
Selenium
Vitamin E is a fat-soluble vitamin, and technically the name for a full set of components called tocopherols.
WHAT IT IS:
WHERE IT COMES FROM:
Tuna, liver, oysters, and clams are excellent food sources of selenium, but Brazil nuts top the scales with up to 700 percent of daily value in just one serving!
WHAT TO LOOK FOR:
Supplemental selenium is best used by the body when it is chelated to the amino acid glycine.
Selenium is an essential mineral for the thyroid, immune system, and overall vitality. MAIN USE:
Selenium helps convert thyroid hormone T4 to active T3, protects cells throughout the body from oxidative damage, and can help balance immune responses, making it especially useful for anyone with autoimmune disorders. Scientific research shows that selenium may help prevent tumor growth— low levels of the mineral could be a risk factor for prostate cancer.
MAIN USE:
Vitamin E prevents the oxidation and buildup of “sticky” LDL cholesterol in the blood vessels, and is often part of a heart-friendly regimen. In fact, natural levels of vitamin E can be boosted with CoQ10 supplementation. It is also an important antioxidant active in the outer layers of the skin and hair, where it protects those cells from oxidative damage. In addition, vitamin E keeps nerve cell signaling strong, fortifies the immune system, and helps DNA replicate properly.
TYPICAL DOSAGE:
50 - 100 MCG DAILY 28
TYPICAL DOSAGE:
E WHERE IT COMES FROM: Vitamin E
is found naturally in sunflower seeds, almonds, spinach, broccoli, and hazelnuts. WHAT TO LOOK FOR:
cal: Botani
Boswellia WHAT IT IS:
Boswellia (Boswellia serrata) is a botanical used for centuries by Ayurvedic practitioners in India.
WHERE IT COMES FROM:
Boswellia from various species is found in Asia, the Middle East, and Eastern Africa.
The best form of vitamin E is when it contains a full family of mixed tocopherols and tocotrienols, an MAIN USE: under-recognized Boswellia component of the outperforms nutrient. While much conventional vitamin E research has drugs and focused on tocopherols, other strong study of tocotrienols botanicals by has found that while fighting 5-LOX they protect brain inflammation— cells, stop oxidative WHAT TO LOOK associated with damage, prevent FOR: Look autoimmune, tumor formation, for boswellia digestive, and lower cholesterol standardized respiratory, and levels, they do so along for at least 10 joint disorders— different pathways percent of a including colitis, than tocopherols. compound COPD, and Additionally, abbreviated as rheumatoid tocotrienols may have “AKBA”, which arthritis. anti-inflammatory is boswellia’s Properly capabilities that most researched standardized, tocopherols lack. These and beneficial it is ideal for naturally occurring component. anyone dealing components work This with asthma, synergistically, and concentrates allergies, IBS, this is how the vitamin the herb’s and muscle is found in foods. power to 10 recovery as Many supplements, times that of an well. Scientific however, only provide unstandardized research shows the d-alpha tocopherol supplement. that boswellia form of vitamin E, may also prevent which is far from the tumor growth. complete form, and can’t provide its full potential. At minimum, TYPICAL DOSAGE: look for a supplement that contains all four 500 MG ONCE tocopherols—d-alpha, OR TWICE DAILY beta, gamma, and delta.
15 - 30 MG DAILY
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ALT ERNATIVE
MEDICINE CHEST
NATURE’S BREAST CANCER DEFENDERS
Taking proper steps to prevent breast cancer is important for everyone, not just people who are aware of it because it “runs in the family.” In fact, while many people are still under the assumption that breast cancer is largely a genetic disease, research suggests that this is hardly the case. Statistics show that approximately 85 percent of all people with breast cancer don’t have a single, first-degree relative with the disease. Instead, science tells us that many cancer cases occur due to genetic changes that happen as the result of the normal aging process. This year alone, it’s estimated that 268,600 new cases of invasive breast cancer will be diagnosed in women in the United States, in addition to 62,930 new cases of non-invasive breast cancers. The good news is that nature provides a number of nutrients and botanicals that can help prevent breast cancer—and scientific research is proving just how effective these natural solutions can be. 30
Curcumin:
It’s no secret that persistent, lowlevel inflammation in the body can contribute to many diseases, including cancer. Curcumin is a potent, natural anti-inflammatory that may play a role in preventing breast cancer by shutting off the blood supply to tumors and triggering apoptosis among cancer cells. Some controlled studies have found that curcumin has an effect on highly invasive and aggressive forms of the disease, like antiestrogen-resistant and triple-negative breast cancers. Researchers have also studied the effects of curcumin
Pomegranate Seed Oil: High on the list of cancer-fighting foods, pomegranates are a delicious, ruby-red fruit with seeds that contain a powerful combination of antioxidants, including anthocyanins and polyphenols. The oil from pomegranate seeds also delivers a disease-fighting dose of omega-5 fatty acids. This unique fatty acid has been shown to inhibit both estrogen-sensitive and estrogen-insensitive breast cancer cells. In a cellular study, omega-5s stopped the proliferation of two types of cancer cells by 92 percent and 96 percent, respectively. In the same study, omega-5 fatty acids also supported apoptosis (cancer cell death) in two types of breast cancer cells by 86 percent and 91 percent. A separate study found that pomegranate seed oil showed a 90 percent inhibition of MCF-7 breast cancer cells, as well. Omega-5 fatty acids also have some of the same abilities of the anticancer drug tamoxifen, but without the drug’s dangerous side effects. If you have an elevated risk for breast cancer, consider supplementing with pomegranate seed oil. Researchers note that pomegranate seed oil has excellent chemo-preventive potential—either on its own or in addition to conventional therapy. A beneficial dose of pomegranate seed oil is 600-1,200 mg daily.
on MCF-7 cells that become resistant to antiestrogen drugs like tamoxifen. One preliminary cell study found that curcumin helped to induce apoptosis of breast cancer cells. In a separate study of triple-negative breast cancer cells, curcumin prevented angiogenesis, which is the growth of new blood vessels that feed cancer tumors. The most effective forms of curcumin are enhanced with turmeric essential oil including arturmerone, which boosts absorption by the body. Look for an extract called BCM-95 (also listed on supplement labels as Curcugreen), a form that is backed by over 50 published studies.
Iodine:
Iodine provides a number of health benefits, including the protection against breast cancer. Scientific tests using estrogen-sensitive breast cancer cells exposed to iodine have shown that they are less likely to grow and metastasize. The reason that iodine is so beneficial to breast health is because it makes breast cells less sensitive to estrogen and detoxifies certain toxins like bromide, fluoride, and chloride. Iodine has also been
Grape Seed Extract: Once cancer cells have taken hold in the body, they’ll fight with a fury to survive. Thankfully, various studies have shown that grape seed extract can be beneficial in preventing breast, prostate, and colon cancer. Research also shows that grape seed extract has an impact on cancer stem cells. However, grape seed extract is the most adulterated botanical in the world, which means you have to be extremely careful about the supplement you choose. One unique form of French grape seed extract called VX1 is unadulterated and has shown tremendous promise in reducing cancer risk. VX1 contains small, easily absorbed oligomeric proanthocyanidins (OPCs). Studies have shown that VX1 has the ability to inhibit the growth of tumors, stop the cycle of cancer cell signaling, and induce apoptosis. More importantly, preliminary research suggests that VX1 can kill cancer stem cells. These stealthy stem cells are why some cancers reoccur, primarily because they aren’t completely eliminated during chemotherapy. While this lab study was done on colon cancer cells, it shows promise for similar types of cancer stem cells, as well. Additional cell studies investigated grape seed extract’s impact on breast cancer cells, either alone or when used as part of conventional cancer treatment. Both strategies proved to be effective, but grape seed extract by itself was also able to inhibit the proliferation of breast cancer cells.
found to be beneficial for treating fibrocystic breast disease. In clinical research, approximately 70 percent of patients experienced pain relief and a reduction in abnormal tissue with iodine supplementation. In patients with mastalgia (breast pain), at least 50 percent of the women studied reported significant reductions in breast pain after taking 6 mg of iodine each day. In a separate study, 98 percent of women receiving iodine treatment
were pain free by the study’s end, and 72 percent showed improvements in breast tissue. For optimal health, an iodine supplement should deliver three different forms of iodine, including molecular iodine, sodium iodide, and potassium iodide. The right dosage depends on the unique needs of each individual, so it’s important to consult with your doctor about how much iodine is right for you. 31
Research Roundup SPECIAL FOCUS ON
Grape Seed Extract French Grape Seed OPCs: Cancer-Preventive Compounds You’ve probably heard about grape seed extracts, especially for heartrelated conditions. Unfortunately, many grape seed extracts on the market are either adulterated with other ingredients, or are so encumbered with tannins— compounds that limit absorption— that they are virtually useless. However, grape seed extracts that are free of tannins allow their beneficial components, called oligomeric proanthocyanidins or OPCs, to absorb fully in the digestive tract and ultimately enter into the cells that most need their healing attention. Leading research shows that the right grape seed extract may be the next breakthrough in the fight against cancer. The studies highlighted here show the value of a French grape seed extract (VX1), standardized for low molecular weight (think “small”) OPCs in stopping colorectal cancer cells from growing and recurring. According to the Centers for Disease Control and Prevention (CDC), colorectal cancer has the second highest mortality rate in the United States. Fortunately, this latest research provides insight and hope into the newest directions in preventing this cancer and others as well.
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It’s our goal here at Integrative Lifestyles to bring you the latest in cuttingedge research for a variety of common health issues. Because we believe that knowledge is power—especially when it comes to health—we are digging deeper into the exciting new research from leading medical journals and breaking it down to help you get the most from today’s science.
Stopping Stem-Like Cell “Seeds” with French Grape Seed OPCs
THE STUDY ABSTRACT:
tumor organoids. Collectively, we have comprehensively assessed antitumorigenic properties of OPCs and our data throws light on previously unrecognized chemopreventive mechanisms of OPCs highlighting its therapeutic potential.
Proanthocyanidins are a heterogeneous group of flavan-3-ol or flavan-3,4-diol oligomers present in various fruits and vegetables. In particular, the smaller oligomeric subset of proanthocyanidins, termed the oligomeric proanthocyanidins (OPCs) appear to have potent anti-tumorigenic properties, but the underlying mechanisms for their effectiveness remain unclear. Herein, we utilized a series of in vitro, in vivo and patient-derived organoid approaches to systematically investigate the chemoprotective role of OPCs in colorectal cancer. OPCs exerted anti-tumorigenic effects through inhibition of cellular proliferation, and induced apoptosis and cell cycle arrest. Intriguingly, OPCs suppressed spheroid derived cancer stem-like cell formation and decreased the expression of intestinal cancer stem cell markers including LGR5, CD44 and CD133. Mechanistically, RNAsequencing results confirmed that OPCs prominently interfered with developmental and self-renewal pathways and identified several self-renewal associated oncogenes targeted by OPCs. Furthermore, OPCs inhibited Hippo pathway through downregulation of its key transcriptional regulators, YAP and TAZ. Finally, we confirmed antitumorigenic effects of OPCs using multiple xenograft experiments and recapitulated its protective effects using patient-derived colorectal
Source: Toden S, Ravindranathan P, Gu J, Cardenas J, Yuchang M, Goel A. Sci Rep. 2018 Feb 20;8(1):3335.
Oligomeric proanthocyanidins (OPCs) target cancer stemlike cells and suppress tumor organoid formation in colorectal cancer.
WHAT IT MEANS TO YOU:
Cancer stem cells, the “seeds” of recurring cancer, resist chemotherapy. They essentially hide in the body, remerging later—sometimes years following treatment. When this happens, the new cancer is even more resistant to treatment. Researchers at Baylor found that French grape seed extract (VX1) stopped the regeneration of cancer stem cells by blocking a specific pathway in the body, abbreviated as HippoYAP. In studies, it actually prevented the ability of tumor cells to grow and spread, and eventually killed them altogether. This is an effect not seen with conventional drugs, so these results show the potential for OPCs from grape seed to do something completely unique. In this case, the viability of cancer cells exposed to the extract decreased by 70 percent. Further study using an animal model showed that the VX1 extract suppressed tumor growth by 90 percent. This study shows that the frontiers of natural cancer fighting are still being explored and that the potential for the right kind of grape seed extract—one that is tannin-free and specifically standardized for OPCs—is massive. According to the researchers, a human equivalent dose could be a small addition to a daily regimen—only about 300 mg to 600 mg per day.
French Grape Seed OPCs Improve the Effect of Some Chemotherapy Drugs
For Results, Grape Seed OPCs Are the Critical Factor
THE STUDY ABSTRACT:
THE STUDY ABSTRACT:
Oligomeric proanthocyanidins (OPCs) from grape seed extract suppress the activity of ABC transporters in overcoming chemoresistance in colorectal cancer cells. Multidrug resistance is a major hindrance in managing cancer. By performing a series of experiments in chemoresistant colorectal cancer cell lines, we demonstrate that oligomeric proanthocyanidins (OPCs) from grape seed extracts can sensitize both acquired (HCT116-FOr cells) and innately chemoresistant (H716 cells) cancer cells to chemotherapeutic drugs, 5-fluorouracil (5FU) and oxaliplatin, by inhibiting ABC transporter proteins. When combined with chemotherapeutic drugs, OPCs significantly inhibited growth of the chemoresistant cells (p<0.05 to p<0.001), and decreased the expression of several key ABC transporters. Moreover, the activity of the ABC transporters was also significantly decreased by OPCs in the cell lines (p<0.05). We further confirmed that co-treatment with OPCs sensitized the chemoresistant cells to 5FU and oxaliplatin, as observed by improvement in cell cycle arrest, double strand breaks and p53 accumulation in these cells. Additionally, we confirmed that coadministration of OPCs with chemotherapeutic drugs significantly decreased chemoresistant xenograft tumor growth in mice (p<0.05). Together, our study illuminates the downregulation of multiple ABC transporters as a mechanism by which OPCs overcome chemoresistance in cancer cells, and may serve as adjunctive treatments in patients with refractory colorectal cancer. Source: Ravindranathan P, Pasham D, Goel A. Carcinogenesis. 2018 Dec 29.
WHAT IT MEANS TO YOU:
One of the biggest barriers to conventional cancer treatment is that cancer cells become resistant to chemotherapy drugs. Trying to overcome that with higher dosages isn’t always an option because of the terrible side effects chemotherapy drugs can have on patients. This study found that the oligomeric proanthocyanidins (OPCs) from a French grape seed extract (VX1) inhibited the growth of resistant cancer cells and the proteins that would otherwise help them thrive. This means that the French grape seed OPCs could be part of an adjunct therapy—a beneficial add-on—to chemotherapy in patients with colorectal cancer.
Mechanistic insights into anticancer properties of oligomeric proanthocyanidins from grape seeds in colorectal cancer. Although the anticancer properties of oligomeric proanthocyanidins (OPCs) from grape seeds have been well recognized, the molecular mechanisms by which they exert anticancer effects are poorly understood. In this study, through comprehensive RNA-sequencingbased gene expression profiling in multiple colorectal cancer cell lines, we for the first time illuminate the genome-wide effects of OPCs from grape seeds in colorectal cancer. Our data revealed that OPCs affect several key cancer associated genes. In particular, genes involved in cell cycle and DNA replication were most significantly and consistently altered by OPCs across multiple cell lines. Intriguingly, our in vivo experiments showed that OPCs were significantly more potent at decreasing xenograft tumor growth compared with the unfractionated grape seed extract (GSE) that includes the larger polymers of proanthocyanidins. These findings were further confirmed in colorectal cancer patient-derived organoids, wherein OPCs more potently inhibited the formation of organoids compared with GSE. Furthermore, we validated alteration of cell cycle and DNA replication-associated genes in cancer cell lines, mice xenografts as well as patient-derived organoids. Overall, this study provides an unbiased and comprehensive look at the mechanisms by which OPCs exert anticancer properties in colorectal cancer. Source: Ravindranathan P, Pasham D, Balaji U, Cardenas J, Gu J, Toden S, Goel A. Carcinogenesis. 2018 May 28;39(6):767-777.
WHAT IT MEANS TO YOU:
This study tested grape seed oligomeric proanthocyanidins (OPCs) against a plain, or unfractionated grape seed extract (GSE) that was not tannin-free, nor specifically standardized for the compounds. One of the insights garnered by this research was not just how the OPCs affect cancerrelated genes and stop the cell growth cycle, but how much more effective the smaller-sized (low molecular weight) OPCs were in comparison with the larger proanthocyanidins from the regular grape seed extract. These OPCs target specific microRNAs—in this case the microscopic engineers that replicate cancer cells—and prevent cancer by directly inducing apoptosis (the programmed death of damaged cells). It also
CONTINUED>>
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Research Roundup
SPECIAL FOCUS ON
Grape Seed Extract
boosted levels of tumor suppressor genes, downregulated tumor promoting genes, and prevented the migration of cancer cells. Although this research focused on colorectal cancer, there are similar types of activity across nearly all kinds of malignancies. In fact, the researchers found that the grape seed worked along so many tracks that in their study they mention, “… no single clinical therapeutic has the
ability to effectively block multiple oncogenic pathways…” That alone is an incredible breakthrough. But in vivo tests found something else even more applicable to everyday life. Because the tannin-free OPCs from French grape seed extract were more absorbable than the tannin-bound OPCs from unfractionated grape seed extract, the botanical ingredient was much more effective at much lower dosages. For example, animal studies found that even at smaller amounts, OPCs were much more effective than standard grape seed extract at reducing
tumor size. In just 13 days, 100 mg of OPCs reduced tumor size by 65 percent. Even a 50 mg level brought the tumor size down 40 percent. Compared to standard grape seed extract at only 13 percent and 8 percent, respectively, it shows how much of a difference it makes to get a tannin-free grape seed extract with absorbable OPCs that can reach their full potential. Additionally, there were no harmful effects on healthy cells—these actions were targeted to cancer cells only. Scaled up for human use, researchers determined that low daily dosages—just 240 mg per day—were sufficient.
French Grape Seed OPCs Plus Curcumin Are Superior Anti-Carcinogens
THE STUDY ABSTRACT:
A combination of curcumin and oligomeric proanthocyanidins offer superior anti-tumorigenic properties in colorectal cancer. Combining anti-cancer agents in cancer therapies is becoming increasingly popular due to improved efficacy, reduced toxicity and decreased emergence of resistance. Here, we test the hypothesis that dietary agents such as oligomeric proanthocyanidins (OPCs) and curcumin cooperatively modulate cancer-associated cellular mechanisms to inhibit carcinogenesis. By a series of in vitro assays in colorectal cancer cell lines, we showed that the anti-tumorigenic properties of the OPCs-curcumin combination were superior to the effects of individual compounds. By RNA-sequencing based gene expression profiling in six colorectal cancer cell lines, we identified the cooperative modulation of key cancer-associated pathways such as DNA replication and cell cycle pathways. Moreover, several pathways, including protein export, glutathione metabolism and porphyrin metabolism were more effectively modulated by the combination of OPCs and curcumin. We validated genes belonging to these pathways, such as HSPA5, SEC61B, G6PD, HMOX1 and PDE3B to 34
be cooperatively modulated by the OPCs-curcumin combination. We further confirmed that the OPCscurcumin combination more potently suppresses colorectal carcinogenesis and modulated expression of genes identified by RNA-sequencing in mice xenografts and in colorectal cancer patient-derived organoids. Overall, by delineating the cooperative mechanisms of action of OPCs and curcumin, we make a case for the clinical co-administration of curcumin and OPCs as a treatment therapy for patients with colorectal cancer. Source: Ravindranathan P, Pasham D, Balaji U, Cardenas J, Gu J, Toden S, Goel A. Sci Rep. 2018 Sep 14;8(1):13869.
WHAT IT MEANS TO YOU:
Tannin-free French grape seed extract with highly absorbable OPCs has already shown strong antitumor effects in prior research. This study combined the OPCs from French grape seed extract with a curcumin from turmeric that is blended with turmeric essential oil and arturmerone, a beneficial compound within the oil, for greater absorption. Both grape seed OPCs and curcumin work along multiple pathways in the body to reduce inflammatory damage to healthy DNA, help prevent cancer cells from replicating, and inhibit the
growth and development of tumors. What’s interesting here is that these two botanical ingredients work along differing paths, and because of this, they can cover more ground in the battle against cancer than either one could separately. As in the other studies, an important key is the form of the ingredients used in the study. The grape seed (VX1) is tannin-free and specifically standardized for OPCs that can be absorbed in the digestive tract, enter the cells, and start repairing them (or triggering apoptosis, if they’re cancerous.) The curcumin, known as BCM-95/Curcugreen, shouldn’t be confused with plain turmeric or standard extracts. It uses turmeric essential oil, not piperine, to boost absorption and help it remain in the bloodstream longer. As the researchers note in their study, it has become increasingly popular to combine cancer-prevention therapies. Both French grape seed OPCs and curcumin represent a one-two punch for reducing cancer risk. The French grape seed is water soluble—it absorbs quickly and works fast. The curcumin is fat soluble and remains in the body longer. This research suggests that this dynamic duo may be an excellent addition to standard therapies.
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