Microscopic Teaching (10/28) Epithelial Neoplasm (I) 2979 (21) Pleomorphic adenoma, parotid gland 3244 (42) Squamous cell carcinoma, esophagus 4203 (98) Basal cell carcinoma, lip
2979 (21) Pleomorphic adenoma, parotid gland • Tumor: (1) epithelial (2) mesenchymal (3) hematological (4) divergent differentiation • Pleomorphic adenoma (mixed tumor) (1)60% parotid gland tumors (2)often encapsulated (3)biphasic appearance: epithelial and mesenchymal differentiation (4)matrix: myxoid, hyaline, chondroid, osseous (5)epithelium: ducts, acini, tubules, strands, sheets
Well-defined tumor, with pushing growth border, and heterogeneous component
Well-defined tumor, with pushing growth border, and heterogeneous component
A little normal protid gland tissue can be seen.
A little normal protid gland tissue can be seen.
Mixed epithelial and mesenchymal differentiation.
matrix: myxoid, hyaline, chondroid, osseous
Epithelium: ducts, acini, tubules, strands, sheets
Epithelium: ductal cells and myoepithelial cells
Myoepithelial cells: clear, flattened, spindle shaped
Epithelium: ducts, acini, tubules, strands, sheets
matrix: myxoid, hyaline, chondroid, osseous
Mesenchymal components are modified myoepithelial cells.
3244 (42) Squamous cell carcinoma, esophagus • Anaplasia: (1) pleomorphism (2) abnormal nuclear morphology (3) mitoses (4) loss of polarity (5) tumor giant cells • SCC: partially recapitulate the normal organization of squamous epithelium
tumor
normal
(1) pleomorphism (2) abnormal nuclear morphology (3) mitoses (4) loss of polarity (5) tumor giant cells
Muscularis propria invasion
Adventitia invasion
Keratin pearls
Keratin pearls (角化珠)
mitoses
tumor giant cells
Single cell dyskeratosis
Single cell dyskeratosis
pleomorphism
Perineural invasion
Stromal desmoplasia
4203 (98) Basal cell carcinoma, lip • Most common skin cancers, on sunexposed skin • Slow growing • Nests of uniformly atypical basaloid cells with peripheral palisading • Stroma retracts away from the carcinoma: creating clefts • Tumor cells attemp to differentiate toward adnexal structures
Tumor nests in the dermis
Irregular tumor nests in the dermis
Connection with overlying squamous epithelium
Locally invasive growth
Locally invasive growth
Bright red trichohyaline granules, dystrophic calcification
Stroma retracts away from the carcinoma: creating clefts
Stroma retracts away from the carcinoma: creating clefts
Stroma retracts away from the carcinoma: creating clefts
Peripheral palisading: arranged radially with their long axis in parallel alignment
Melanin pigmentation
Normal follicular epithelium
BCC: follicular bulbar differentiation
Bright red trichohyaline granules