Steps to Cancer Indiv. Probablitites
Levels of Organization Organism
Lethal Cancer
3
Clonal Expansion
2
Cells
Promotion Initiation
1
Atoms
Metastases
-
Tissues
Molecules - DNA
Physiological Defenses With Indiv. Probablitites Under Genetic Control
Mutation x Mutation 1
-
DNA-Damage Radiat.
Toxins
<2%
> 98 %
IMMUNE RESPONSE INFLAMMATION IMMUNE RESPONSE APOPTOSIS APOPTOSIS CELL SENESCENCE DNA REPAIR DETOXIFICATION SCAVENGING
Steps to Cancer Indiv. Probablitites
Levels of Organization Organism
Lethal Cancer
3
Clonal Expansion
2
Cells
Promotion Initiation
1
Atoms
Metastases
-
Tissues
Molecules - DNA
Low Doses Can Up-regulate Physiologoical Defenses
Mutation x Mutation 1
-
DNA-Damage Radiat.
Toxins
IMMUNE RESPONSE INFLAMMATION IMMUNE RESPONSE APOPTOSIS APOPTOSIS CELL SENESCENCE DNA REPAIR DETOXIFICATION SCAVENGING
Adaptve Protecton after Acute Low-LET Irradiaton Cell level ( 10); Cancer + ( 5); Immune resp. ( Bystander damage ( 1); Enzyme-inactv. – TdR-K (
Percent Protecton
100
18 Studies
80 60
0
€ €€
40 20 0
- 20
100
200
300 Dos e (mGy)
400
500
600
1) 1)