This image is of a neuropshere consisting of neural progenitor cells derived from human fibroblasts. The cells, stained for the markers NESTIN (red), BIII-tubulin (green), and DAPI (blue), are currently migrating away from the center of the sphere. Image by Ngoc Tran, Associate Researcher, Brennand Lab (Psychiatry)
This image depicts the molecular network of ~20,000 striatal genes from a mouse population modeling the natural spectrum of stress susceptibility. This Bayesian network was built by integrating genetic and gene expression data from more than 100 (B6xA/J)F2 mice, and the key driver nodes, which regulate the expression of the majority of the network, are labeled in red. Image by Joseph Scarpa, Kasarskis/Schadt Lab (Genetics and Genomic Sciences)
Topology of the human speech production network. The color of a node represents its strength; its connectivity is illustrated by its size. Image by Stefan Fuertinger, Postdoctoral Fellow (Neurology)
Alcohol trigger site in brain: Three dimensional atomic structure of an ion channel protein that contains an alcohol (red-yellow) buried in a pocket formed by three regions (blue, green and orange) of the channel protein. Image by the Slesinger Laboratory (Neuroscience)
Neurosphere: Neural stem cells, isolated from mouse brain, aggregate into a spherical structure called a neurosphere when grown in cell culture. The cells are capable of becoming mature neurons, as shown by red labeling. Understanding the differentiation and growth of neural stem cells is being pursued as a repair strategy for spinal cord and brain injury. Image by Hongyan (Jenny) Zou, MD, PhD (Neurosurgery and Neuroscience)
Naked nerve fibers in a new mouse model of leukodystrophy Image by Yuko Hara, PhD, Assistant Professor (Neuroscience) in collaboration with the John, Casaccia, and Friedman Laboratories
Itgb4_Phalloidin. Image by Laura Grisanti, Postdoctoral Fellow (Ophthalmology)
This is a fluorescein angiogram of a patient with Sjogren's reticular dystrophy. The reticular pattern of opaque tissue at the level of the retinal pigment epithelium blocks choroidal fluorescence. Normal retinal blood vessels are seen overlying the retina. We have identified a candidate gene for this very rare disorder by whole-exome sequencing at Mount Sinai. Image by Scott E. Brodie, MD, PhD (Ophthalmology)
Monkey PFC synapses and mitochondria long. Image by Yuko Hara, PhD, Assistant Professor (Neuroscience)
Image of neurons in the prefrontal cortex, an area responsible for your executive functioning, including planning, decision making, problem solving, and social behavior. The top panel shows neurons in a typical child, and the bottom in a child with autism; note the qualitative increase in neuron number in the child with autism. Image by Neha Uppal, PhD (Neuroscience and Seaver Autism Center)
Structure of the spinal intervertebral disc: The highly fibrous annulus fibrosus shown in this image allows mobility of the spine while withstanding the very large axial and shear loads that can be up to 5 times body weight. This image is taken from mouse annulus fibrosus, using methacrylate thin sections and methylene blue staining. Image by Svenja Illien-Junger, PhD, Post-doctoral Associate, Leni & Peter W. May Department of Orthopaedics