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january 26, 2022
PAGE 2
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NNew e wHope H ofor p Treating e f o r Neurodegenerative T r e a t i n g N Diseases eurod e g e nhave e rsearched ative Diseases (NAPS)—Scientists
for decades ( N Awithout P S )success Ñ S cfori eways n -to t irepair s t s thehdevastating a v e s damage e a r ccaused h e dby f oneurodegenerative r d e c a d ediseases, s wbut i t hthere o uaret now snew u ccompounds c e s s in fclinical or w development a y s t othatroffer e phope. air the d e v a s t a The t i nProblem g dama g eWhen c a there u s eisd a bmass y ndie-off e u -of r oneurons d e ing the e nbody, e rthea central t i v nere d ivous s e system a s e smisfires , b ulike t at faulty h e r cire cannotc obemfixed a rcuit e board—one n o w nthate w p owithout u n dreplacing s i nthe cblown l i nfuses. i c aThis l d emajor v e physiological l o p m e nmalfunction t t h tends at o ftoftrigger e r htheoonset p e of. some of the harddiseases, T est-to-treat h e P r oneurodegenerative blem including W h eAlzheimer’ n t h es disease r e iand s mula mtiple a s sclerosis s d(MS). ie-off of n e uThese r o are n sterrible afflictions i n thatt haffect e b omillions d y , of Northt hAmericans. e cThey e nalso t rcost a lthe healthcare n e r . vsystem o u sbillions s yofsdolt elars m a year, m mostly i s f i spent r e s on managing like a physical f a and u l mentally t y debilitating c i r . c usympit inexorably b otoms a rthat dÑ o n e get worse. t h a t c a nWhat’ n ostmore, current b e treatments f i x e can d w only i t h“modify” o u t (slow r edown p l aorcmitigate) ing t hthee destructive b l o weffects n onf uthes human es. T body h i scaused m by a jthe o rmasspdeath h yofs neuispine. o lrons o ginithe c abrain l or m alfunct i o n Thet eSearch n d sFor tAoSolution trigg e rWithtthat h eall said, o nmany s e people t omay f s obemrelieved e otof learnt hofea small h aCanadirde san-headquartered t - t o - t r e abiotech t n start-up e u r othat d eoffers g enew n e hope r a ttoi vtense of millions d i s -of e asufferers s e s ,of neurodegenerative i n c l u ddiseases. ing A With l z hPhase e i m1eclinical r Õ s trialsd already ise aunderway, s e a nNervGen d m Pharma u l . t i believes ple s cit’sl eon-track r o s itos become ( M Sa) big . breakthrough T h ethanks s e toaitsr eblockbuster t e r r drug ib lcandidate—NVG-291. e afflictions that is ai peptide a f f NVG-291 ect m l l i o (an ssmalloprof N tein) o r tthat h works A by m targeting e r i c athen spro. T tein h etyrosine y a phosphatase l s o c o ssigma t t(PTPσ) he h ereceptor a l t hthat c ablocks r e nerves repair y s t followem from b iingl linjury, i o nwhether s o f traumad oro conl. l aditions r s such a yas eMSa or r ,Alzheimer’ m o ss tdiscellarepair, l yease. sNervGen p e n ttargets o nnervem na gwhile i n promoting g p h y splasticity i c a lto create a nnew d mneural e n tpathways. ally debilibrainchild of Dr. t a t iNVG-291 n g issthe ym p.tom s t hJerry a t Silver, i n e ax renowned o r a b l spinal y g ecord t w injury o r s eand . regenerative medicine researcher W hwhose a t ’ s pioneering m o r work e, c uaddresses r r e n ta diversity t r e a tofmconditions ents c adefined n obyn al ydamaged “ mcentral o d i nervous fy” ( ssystem. l o wThese d oinclude w n degenerative o r m i tdisi geases, a t espinal ) t hcorde damage, d e s tstroke r u cand t i traumatic v e e fbrain f e injury. cts on the h u mResearchers a n b oared ycurrently c a uconductsed b ying trials t h ein healthy m a volunteers. s s d eThis a t will h o ftransition n e uto. studies r o n sfor several i n oft hthese e b rmedical a i n aliments. o r sInpparticular, i n e . the company has stepped up its interest in NVGT291’ h seability S etoatackle r c Alzheimer’ h F o srdisease. A The company S o l u works t i o nwith Dr. Ksenia Kastanenka of Massachusetts General Hospital—which has a long history of supporting cutting-edge research
With that all said, many people may be relieved to learn of a small Canadi.an-headquartered biotech start-up that offers new hope to tens of millions of sufferers of neurodegenerative diseases. With Phase 1 clinical trials a l r e a d y u n d e r w a y, NervGen Pharma b e l i e v e s i t ’s o n track to become a big break.through thanks to its blockbuster drug candidDr.aSilver, t e Ñrenowned N V G -spinal 2 9 1cord . injury N and V Gregenerative - 2 9 1 i smedicine a p ereptsearcher, i d e studies ( a snew m treatments a l l p rfor o. tMSe and i n )Alzheimer’s. that works by targeting the pandr oinnovation . t e i n in medical t y rresearch— osine pto hstudy o sNVG-291 p h a t in a sanimal e models s i gof Alzheimer’s disease. m a ( P T P. ) r e c e p t o r t hIt’as also t preparing b l o c tok enter s anPhase e r v1be
www.lonestarshoppertx.com repair f o l l o w. i n g i n j u r y, whether from trauma or con.ditions such as M S o r A l z h e i m e r ’s dis.ease. NervGen targets nerve cell repair, while promoting plasticity to create new neural pathways. NVG 2 9online 1 posting is the Lead-in copy- for b r a i n c h i l d o f D r. Jerry Silver, a renowned spinal cord injury and regenerative medicine researcher whose pioneering work addresses a diversity of conditions defined by a damaged central nervous system. T h efeed s ecopyi n c l u d e d e Twitter generative dis. eases, spinal cord damage, stroke and traumatic brain inj u r y. Researchers are currently conduct. ing trials in healthy volunteers. This willtransition to Tag s twords udies for several of these medical
clinical trial for Alzheimer’s patients in 2022 following ongoing Phase 1 safety trials for the drug candidate. An Expert’s Opinion According to NervGen’s CEO, Paul Brennan, “The multiple preclinical studies that we are conducting, as well as our planned Phase 1b study, are important milestones for our Alzheimer’s pro- Tweet This gram, which, if successful, will provide a meaningful benefit to patients and significant potential for NervGen. “What differentiates NVG-291 from other drugs in development is that it leverages multiple mechanisms for repairing nerve damage, while most others focus on a single approach. Alzheimer’s disease is a complex condition and likely caused Google Search Ad by multiple factors. We believe that a systems approach to treating the disease is an important distinction.” Brennan adds, “All told, NVG-291’s ability to remyelinate and enhance plasticity is a one-two knockout punch for repairing a damaged central nervous system, which is the end result on a diversity of neurodegenerative diseases, as well as traumatic brain and spinal inju- Outbrain Native Ad ries. NVG-291 could herald a revolutionary new paradigm in treating all of these chronically debilitatingSage conditions. ” 105 West Street •Winnsboro, The company’s continued strides toward launching this new class of drugs offers renewed hope to millions. Learn More For further facts on the research and clinical trials, go to www.nervgen.com.
aliments. In particular, the com. pany has stepped up its interest in NVG.291Õs ability to tackle AlzheimerÕs disease. The company works with D r. Kse.nia Kastanenka of Massachusetts Gen.eral HospitalÑwhich has a long history of supporting cutting-edge research and innovation in medical researchÑ to study NVG-291 in animal mode l s o f A l z h e i m e r ’s disease. I t ’s a l s o p r e p a r i n g to enter a Phase 1b clinical trial for AlzheimerÕs patients in 2022 following ongoing Phase 1 safety trials for the drug candidate. A n E x p e r t ’s O p i n ion According to NervGenÕs CEO, Paul Brennan, ÒThe multiple preclin-
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ical stud.ies that we are conducting, as well as our planned Phase 1b s t u d y, a r e i m p o r t ant milestones for our AlzheimerÕs pro.gram, which, if successful, will provide a meaningful benefit to patients and sig.nificant potential for NervGen. ÒWhat differentiates NVG-291 from other drugs in development is t h a t i t l e v e r. a g e s multiple mechanisms for repairing nerve damage, while most others focuson a single approach. AlzheimerÕs diseaseis a complex condition and likely caused by multiple fact o r s . We b e l i e v e that a sys.tems approach to treating the disease is animportant distinction.Ó Brennan adds, ÒAll told, NVG-
• 903-865-7002 291Õs ability to remyelinate and enhance plas.ticity is a one-two knockout punch for repairing a damaged central nervous sys.tem, which is the end r e s u l t o n a d i v e r. sity of neurodegenerative diseases, as well as traumatic brain and spinal inju.ries. NVG-291 could herald a revolution.ary new paradigm in treating all of these chronically debilitating conditions.Ó The companyÕs continued strides toward launching this new class of drugs offers renewed hope to millions. Learn More For further facts on the research and clinical trials, g o t o w w w. n e r v gen.com.
january 26, 2022
WHERE SHOULD WE PARK THE MONEY?
Dear Dave, Our son is 13, and he has been doing some part-time work for a friend of the family. He makes $40 to $60 a week, and he would like to begin investing the majority of what he earns. Do you have a suggestion for a good place he could put his money? Lindsay Dear Lindsay, Well, here’s the thing. At this point in his life, the goal of this investment isn’t wealth. Number one, it’s not a lot of money. Number two, well, it’s not a lot
of money. The goal is to create knowledge, reward his interest in the subject and teach him how to handle his finances when he’s an adult. I’ve got no problem with you helping him open checking or savings accounts at a local bank or credit union. There are lots of good lessons to be learned in reconciling a bank statement, and the value of spending, saving and giving. Then, you could get with a good financial pro, one with the heart of a teacher, and let him open a
mutual fund for $50 a month with you as the custodian. He could learn about compound interest, how to calculate the value of his shares and other things, and all that would be a good learning exercise, too. We did these things with our kids. But keep in mind that over the course of a year—and when you’re 13, that’s an eternity—there’s not going to be a lot of action on the investing side of things. It could be kind of boring for him at times. But he’s better off to learn now that good things don’t always come with flashing lights and whistles.
Faith + Love + Hope Joy + Connection
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The Role Of Engine Air Filters
Ve h i c l e e n g i n e s i n clude complex parts that work in concert to ensure that the car functions p r o p e r l y. When servicing their cars and trucks, vehicle owners may look to many parts of the engine yet overlook a relatively mundane, albeit important, component: t h e a i r f i l t e r. All cars come equipped with air filters, which are essential to optimum engine operation. The engine air filter is the first line of defense against outside air that is being brought in to the car engine to be burned along with fuel to produce combustion. The filter will capture particulate matter that would normally enter a veh i c l e ’s e n g i n e a n d leave sediment. The automotive resource It Still Runs says dirty air can reduce engine efficiency and cause damage over time. Dirty air can compromise the air/fuel mixture that is involved in combustion. Any debris that enters portals in fuel injection systems can compromise that system. In addition, debris can cause fuel to burn less effic i e n t l y, r e s u l t i n g i n p o o r f u e l e c o n o m y. There is no simple answer as to how often an engine air filter should be changed. It largely depends on miles driven and the environment in which the
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january 26, 2022
An engine filter is not the only filter in a vehicle. There also is a cabin a i r f i l t e r. The cabin The engine air filter is the first air filter line of defense against outside does not air that is being brought in to affect enthe car engine to be burned peralong with fuel to produce com- gine formance, bustion. but it does help to vehicle is used. p r o v i d e c l e a n a i r i n Those who reside in s i d e o f t h e v e h i c l e . rural or dusty areas will need to replace The cabin air filter air filters more fre- helps to keep dirt, bacteria, q u e n t l y. D r i v e r s a l s o p o l l e n , e x h a u s t g a s es, and can install air filters more suited to dusty dust from entering t h e H VA C s y s t e m . I t areas. also can be a barrier
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against bugs, leaves and other particles from clogging up the system. The cabin filter also helps to keep the air fresh and odor-free. A clogged filter can result in diminished heating and air conditioning p e r f o r m a n c e , s o i t ’s important to change this filter as well.
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january 26, 2022 C o n s i s t e n c y i s w h a t s e t s J O H N ’ S T I R E S A PA R T
Tire shops come and go but in Mineola and East Te x a s , there is only one name you need to know for tire satisfaction. John’s Tire located at 709 South Pacific in MIneola has been servi n g E a s t Te x a s f o r quite some timw now with quality tires and service. John’s Tires hires only the most knowledegable people to make sure you the customer are treated right the first time. Yo u ’ l l f i n d t h e best tires for economy cars, sedans truck and SUVS as well as tires for use on the ranch or the farm. Here at John’s
Tires of Mineola, they are a locally owned and operated company that focuses on providing the highest quality service, m a i n t e n a n c e , and tires. John’s Tires has been in business for more than 30 years, and will always be your “home town tire source.” On a tight budget? John’s tires has quality used and economy tires for most needs. Yo u c a n a l s o r e p a i r, m o d i f y , o r upgrade your tires at John’s Tires. When you get tires at John’s Tires they will balance as well as rotate tires as needed. John’s is very easy to find. they
are located at709 S Pacific St, Mineola, TX 75773 John’s is open Monday-Friday: 8am-5:30pm Saturdays: 8am12:30pm Sunday: Closed. While at John’s ask about our credit offers. Find us on Facebook and visit John’s on line at www.johnstiresofmineola.com. Don’t ride around on bald tires, make your next stop at John’s Tire Center 709 South Main Mine o l a , Te x a s 7 5 7 7 3 . Yo u c a n C a l l John’s tire at 903-569-5996. John’s also offers brand name feeders for your livestock needs. John’s Tires!
1 3 2 0 W F r a n k S t . G r a n d S a l i n e , Te x a s 7 5 1 4 0 Phone: (903)962-7742 • Cell: (214) 908-3187 Fax: (903) 962-7836 abeltrucksales@suddenlink.net
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ABC AMERICAN CONSTRUCTION American Building you know American time Contractors is lo- Building Don’t wait for the Contraccated at 242 N. 4th tors works on Mo- next storm. Call Street Wills Point, bile Homes as well Brett today at 469TX 75169 as foundation built 323-1296. With over 26 years homes... we do house Our email is britof experience, we leveling all the way tmoreland23@yahoo. have established a to remodeling! Dont com. great working re- hesitate to give us a Before storm sealationship with the call today! son hits put our numhome insurance inR e a d o u r F s c e b o o k b e r i n y o u r p h o n e ’s d u s t r y. We b e l i e v e r e v i e w s amd then contacts. Better yet every customer de- give us a call to set call today and set up serves the best res- an appointment to a meeting with Britt. t o r a t i o n p o s s i b l e , w e h e l p y o u w i t h y o u r T h e r e ’s n o p r e s s u r e can and WILL pro- special needs. and no obligation vide that. we have We o f f e r t h e b e s t i n a n d y o u ’ l l b e r e a d y established a work- commercial, or resi- for spring storms ing relationship with dential repairs. knowing you’ve got the home insurance Roofing, siding, the best in the busii n d u s t r y. We h a v e a g u t t e r s , remodels, ness working on your A+ rating with the storm damage, and construction and BBB! roofing needs. much more. American building R e m e m b e r, t h a t ’s We o f f e r f r e e i n contactors will meet spections, Ask about ABC American with your insurance our five year warran- Building Contractor company at y o u r t y. and roofing compahome to discuss your D o n ’ t f o r g e t o u r n y. unique situation be- crews are licensed We a r l o c a t e d i n c a u s e e v e r y i n s u r - a n d i n s u r e d . We o n l y W i l l s P o i n t a t 2 4 2 ance claim is differ- employ the best. North 4th Street on e n t . We w i l l f i g h t t o ABC American the bricks in downgive you every dollar Building Contractors town Wills Point y o u d e s e r v e t o r e p a i r w i l l g e t y o u r j o b Te x a s 7 5 1 6 9 . your home. Yo u c a n r e l y o n done right the first Another Plus, Did ABC American!
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A B E L H A S W H AT Y O U N E E D !
In the market f o r U s e d Tr u c k s , Tr a i l e r s , o r o t h e r industrial equipment? We l l , y o u n o l o n ger have to travel to Houston, Dall a s , o r Ty l e r. ABEL TRUCK SALES in Grand Saline located at 1 3 2 0 We s t F r a n k in Grand Saline has a fasntastic selection of Tr u c k s , Tr a i l e r s and other industrial equipment. To s e e t h e i r completre inventory visit w w w. abletruck.com. Come to Grand Saline any weekday and see the amazing inventory rady to roll for your next job. Yo u c a n a l s o c a l l them at 903 962-
7742. Thier cell number is 2149 0 8 - 3 1 8 7 . Yo u c a n always fax them at 903-962-7836. For your convenience you can email ABEL TRUCK SALES at abletrucksales@ suddenlink.net. See the ad next to this article to see this week’s special. At ABEL TRUCK SALES we service what we sell. Need financing? No problem, we even have zero per cent financing for well qualified buyers. For more information check out ABLE TRUCK SALES Google reviews. It is definatly worth the drive
to save money on your next heavy duty truck. Make plans to visit with Robbie a n d Te r r y J o r d a n for your next purchase. Located across from E-Z Mart you’ll be glad you came tovisit ABEL TRUCK SALES in the Salt City of Grand Saline. ABEL TRUCK SALES in Grand Saline located at 1 3 2 0 We s t F r a n k in Grand Saline has a fasntastic selection of Tr u c k s , Tr a i l e r s and other industrial equipment. They will work hard to earn your business as well as your respect. ABLE TRUCK SALES!
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Page 8
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5 Reasons to Eat More Tart Cherries
FAMILY FEATURES
I
f you want to add superfoods to your diet in the new year, Montmorency tart cherries may be perfect for you. Montmorency is the variety of tart cherries grown in America, primarily on small family farms. Compared to sweet cherries that are typically eaten fresh during the summer season, tart cherries are available year-round as dried, frozen, canned, juice and juice concentrate. Decades of scientific research has shown Montmorency tart cherries are deserving of their superfood reputation. Here are five reasons to enjoy them more often: n n n
n n
Sleep: Tart cherries are one of the few food sources of melatonin and have been the focus of multiple sleep studies. Exercise recovery: Tart cherry juice has become a popular exercise recovery drink for athletes. Arthritis and gout: Studies have explored the impact of Montmorency tart cherry juice consumption on gout attacks and arthritis symptoms. Heart health: Montmorency tart cherry research has examined blood pressure and blood lipids. Versatility: Although they remain perfect for pie, tart cherries can easily transition from sweet to savory, adding complex flavors to oatmeal, smoothies, salads, granola bars, trail mix and grain bowls.
Look for dried U.S.-grown tart cherries at the store and online for enjoyment at the start of your day and at night in recipes like Tart Cherry Overnight Oats and Tart Cherry Bedtime Bites. Find more recipes and scientific research at ChooseCherries.com.
Tart Cherry Bedtime Bites
Tart Cherry Overnight Oats
Recipe courtesy of the Cherry Industry Administrative Board Servings: 2 1 cup dried tart cherries, plus additional for topping (optional) 1 cup old-fashioned oats 1 cup almond milk 1/2 cup slivered almonds, plus additional for topping (optional) 2 tablespoons tart cherry concentrate 2 tablespoons chia seeds 1/2 teaspoon cinnamon honey, for topping (optional) In large jar or container, mix cherries, oats, milk, almonds, cherry concentrate, chia seeds and cinnamon. Cover and refrigerate overnight. Spoon into bowls and enjoy cold or warmed up. Drizzle with honey or sprinkle with extra dried tart cherries and almonds, if desired.
Tart Cherry Overnight Oats
Tart Cherry Bedtime Bites
Recipe courtesy of the Cherry Industry Administrative Board Yield: 12 bites 6 medjool dates, pitted 1/2 cup dried tart cherries 1/2 cup finely shredded coconut flakes 3/4 cup unsalted cashews 1 teaspoon almond extract 1 pinch fine sea salt In food processor, process dates until broken into peasized bits. Add dried tart cherries, coconut flakes, cashews, almond extract and sea salt; process until combined. Form into 12 balls and chill 2 hours.
A Dark, Colorful Clue The deep red color is your clue to the science-based benefits of Montmorency tart cherries. The vibrant hue is due to the concentration of anthocyanins, a type of polyphenol in the flavonoids family that has been widely studied.
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