NASA’s Johnson Space Center in Houston has served as a hub of human spaceflight activity for more than half a century. As the nucleus of the nation’s astronaut corps and home to International Space Station mission operations, the new Orion spacecraft and a host of future space projects, the center plays a pivotal role in surpassing the physical boundaries of Earth and enhancing technological and scientific knowledge to benefit all of humankind. The center leads the world in spaceflight mission design, preparation, integration and execution: Not an easy task considering the harshness of the space environment.