2 minute read
Determination of iron by potentiometry
6. To learn the technology of making different dosage forms
Module 1: Drug Discovery (8 hrs)
Stages of Drug Discovery - Lead Discovery - Identification - Validation and Diversity of Drug Targets Some Novel Molecular Targets along with their Pharmacodynamic Agents: Polyketide Synthase (Pks13) - Signal Transducer and Activator of Transcription-3 (STAT-3) and Sodium Glucose Cotransporter-2 (SGLT-2) - Stereochemistry and Drug Action: Pharmacodynamic - Pharmacokinetic (Drug Adsorption Metabolism - Distribution and Elimination)-Toxicological Aspects of Stereoisomers (Geometrical Optical and Conformational).
Module 2: Prodrug Design (7 Hrs)
Basic Concepts – Prodrugs - Drug Design - Combating Drug Resistance - Causes for Drug Resistance Strategies to Combat Drug Resistance in Antibiotics Therapy - Genetic Principles Of Drug Resistance.
Module 3: Systematic Study of Drugs-I (7 Hrs)
Study of Drugs –SAR-Mechanism of Action and Synthesis (Synthesis Of Individually Mentioned Drugs only) of New Generation Molecules of Following Classes: Adrenergic Agents (Celiprolol - Olodaterol) Cholinergic Agents (Sazetidine-A) - Antidepressants (Vortioxetine - Levomilnacipram) Anticonvulsants (Levetiracetam - Perampanel) and Psychoactive Drugs (Brexpiperazole - Iloperidone).
Module 4: Systematic Study of Drugs –II (8 Hrs)
Systematic Study - SAR - Mechanism of Action and Synthesis (Synthesis Of Individually Mentioned Drugs Only) Of New Generation Molecules Of Following Classes: Anti-Hypertensive Drugs (Cilazapril - Saprisartan) - H1 And H2 Receptor Antagonists (Dimetindene - Olopatadine - Lafutidine) - Oral Hypoglycemic (Omargliptin - Dulaglutide) - Antineoplastic Agents (Alectinib - Capacitabine) - AntiHIV Agents (Dolutegravir - Elvitegravir).
Module 5: Rational Design of Enzyme Inhibitors (7 Hrs)
Enzyme Kinetics and Principles of Enzyme Inhibitors - Enzyme Inhibitors in Medicine -Rational Design of Non-Covalently and Covalently Binding - Enzyme Inhibitors - Introduction To Artificial Enzymes –Introduction - Design and Therapeutic Applications of Peptidomimetics.
Module 6: Dosage Forms and Preparation (8 Hrs)
Emulsion – Tablets - Capsules (Hard - Soft) – Aerosol – Solution - Need For Different Dosage Forms Ingredients in Pharmaceuticals - Colouring Agents – Cyclodextrin - Gels and Jellies - Flavours -Tablet Coating Technology - Drug Drying Technology – Dryers - Freeze Dryers – Evaporators – Filters –Extrusion - Equipment Cleaning – SOP - GLP and GMP.
Text Books
1. D. J. Abraham, “Burger’s Medicinal Chemistry and Drug Discovery”, John Wiley and Sons Inc., New York. 6th Ed. 2003 2. J. H. Block and J. M Beale, “Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry”, Lippincott Williams and Wilkins, Philadelphia. 12th Ed. 2010 3. T. L. Lemke and D. A. Williams, V. F. Roche and S. W. Zito, “Foye's Principles of Medicinal Chemistry”, Lippincott Williams and Wilkins, Philadelphia. 7th Ed. 2012 Reference Books: 1. R. S. Vardanyan and V. J. Hruby, “Synthesis of Essential Drugs”, Elsevier, Philadelphia. 2006 2. T. Nogrady, “Medicinal Chemistry: A Biochemical Approach”, Oxford University Press, New York. 3rd Ed. 2015 3. J. Swarbrick. “Encyclopedia of Pharmaceutical technology”, volume 1, 3rd ed., 2007
19CH3007 BATTERY TECHNOLOGY
Course Objectives:
1. To understand the electrochemical reactions 2. To know the recent developments in battery technology 3. To understand the environmental problems related to batteries
