Comment 031 November 1988

Page 1

King's College London newsletter

co

GRATULAT 0

S

SIR

JA

ES!

SIR lAMES BLACK, HEAD OF THE DEPARTME T OF A ALYTlC L PHARMACOLOGY AT KI G'S COLLEGE SCHOOL OF MEDlCI EA D DE T1STRY HAS BEE AWARDED THE 1988 OBEL PRIZE FOR MEDlCI E. It will come as no surprise to those who know Sir J ames Black to learn that he i overwhelmed by the media attention which has been accorded him since the announcement on 17 October that he had been awarded the 1988 obel Prize for Medicine; an accolade which he hares with Drs Eliou and Hitchings, American cienti ts involved in the development of cancer treating drugs.

Sir James, Head of the Department of nalytical Pharmacology at King' College School of Medicine and Dentistry since 19 4, has a career history which has alternated between commercial Pharmaceutical companies and academic institu lions, perhaps indicating the conflicting frustrations of company profit margins on the one hand and lack of support for innovative academic research on the other. During his time in industry, Sir J ames was responsible for two major breakthroughs in pharmaceutical research. In 1962, whilst working at ICI, he developed the first clinically proven beta blocker to be used in the treatment of cardiac diseases. Th.. beta blocker, which has the same biochemical shape as Adrenaline, acts as a plug which attaches itself to the nerve fibre receptors in the heart, thereby blocking Adrenaline, preventing over stimulation and bringing relief from pain. Fired by his enthusiasm for this type of lock and key principal, Sir James moved to Smith, Kline and French where he was able to develop an inert replica of Histamine, a substance linked with the overproduction of gastric acid and the resulting peptic ulcers. Again the inert replica acted as a plug thereby suppressing the secretion of the potentially harmful acid. These two discoveries have made fortunes for the drug companies concerned, relieved the pain of millions of suffers and earnt Sir James the respect and admiration of his scientific peers. Sir James Black later moved to the Well,..",.,., .. J:"no,ndation resigning shortly after

a large slice of the company had been noated on the Stock Exchange. In 19 4, King's College was pleased to welcome Sir J ames onto its taff when the new department of Analytical Pharmacology was established within the Faculty of Clinical Medicine at the Medical S hool. Situated in research laboratories within the Rayne Institute, the Department has allowed Sir James to resume his own intuitive research and both to encourage and supervise a progression of postgraduate research students. The Department receives 100% support from outside sources, most notably the Wellcome Foundation, which guaranteed to fund his research for a further five years when he

left them in 19 4. Sir J ame , in his apaity a chairman of the Fa ulty 0 Clinical Medicine Research Committee actively supports and encourages his academic 01leagues to make forays in to the pharmaceutical industry for research funding whilst keeping a watchful eye on academic independence. Sir J ame has now ide-stepped in to the field of commercial research and has set up The James Black Foundation, a mall pharmaceutical research company with a maximum staff of twenty wholly independent and attracting funding in exce of ten million pounds from John on and J ohnson. This company is charity linked and has very close connections with the


Turn static files into dynamic content formats.

Create a flipbook
Issuu converts static files into: digital portfolios, online yearbooks, online catalogs, digital photo albums and more. Sign up and create your flipbook.