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In clinical studies, Pycnogenol® has proven to help reduce the risk of developing cardiovascular diseases.
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Protect your heart and blood vessels
Instructions for use: Pycnogenol® (20 mg): 1–3 tablets a day with some liquid Pycnogenol® Strong (50 mg): 1–2 tablets a day with some liquid Pycnogenol® Forte (100 mg): 1–2 tablets a day with some liquid
Pycnogenol® is recommended: • to patients with cardiovascular disorders as a support to standard therapy • to diabetic patients • to all competitive and recreational athletes • to all smokers • to all who wish to enhance their mental focus, concentration and work performance • for maintaining health, concentration and work performance in stressful situations
For more information and useful advice, visit our website at www.arspharmae.com The food supplement is available in pharmacies and specialized stores.
Manufacturer: Ars Pharmae®, d.o.o. Dunajska cesta 139, SI-Ljubljana T +386 1 4205 730, F +386 1 4205 735 in collaboration with Hankintatukku Oy, Finland 02/2010
Food supplements should not be used as a substitute for a balanced and varied diet. It is recommended not to exceed the indicated daily dose. Keep out of reach of children. The product does not replace medications. Do not use if pregnant or breastfeeding.
Pycnogenol
®
The European Food Safety Authority (EFSA) states that Pycnogenol®: • improves circulation in large and small blood vessels • improves blood circulation in the brain • protects the vascular wall • helps lower blood sugar levels • helps maintain healthy cholesterol levels • helps maintain health through its antioxidative action • reduces lung inflammation, coughing and bronchial spasm • helps reduce swelling in the legs
Lessen the effects of stress
Pycnogenol® is a herbal food supplement extracted from the bark of the maritime pine tree Pinus maritima (Mill). It contains a standardized amount of natural bioflavonoids.
Pycnogenol® is the most potent and effective natural antioxidant. It boosts the organism’s ability to remove free radicals from the body.
Permanent damage to DNA may lead to various diseases due to which cells no longer function at their optimum level. The destructive effect of free radicals is associated with as many as 60 different chronic conditions. 100 %
60 % 40 % 20 %
Pycnogenol®
Grape seed extract
vitamin e
Lipoic acid
vitamin c
0% co q10
Protection from oxidation
80 %
Figure 1: Percentage of lipids protected against oxidation by particular antioxidants
Pycnogenol® is the most effective natural antioxidant. It acts as a scavenger of free radicals – these are highly reactive molecules that are continuously produced within the body. Free radicals react with vital cell components, thereby causing damage to the genetic material – DNA.
Higher levels of free radicals are produced as a result of stress, smoking, UV rays, alcohol consumption, chronic diseases and increased physical activity.
Rohdewald R., A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 2002, 40:158-168 Rohdewald R., Clinical Pharmacology of Pycnogenol®. Pharma Bio World 2006, 79-81 Liu X. et. all, Pycnogenol®, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci 2004, 74:855-862 Hosseini S. Et all, A randomized, double-blind, placebo-controlled, prospective, 16 week crossover study to determine the role of Pycnogenol® in modifying blood pressure in mildly hypertensive patients. Nuts Res 2001, 21:1251-1260 Zibadi S. Et all, Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res 2008, 28:315-320 Bors W. Et all, Electron Paramagnetic Resonance Studies of Redical Species of Proanthocyanidins and Gallate Esters. Arch Biochem Biophy 2000, 374:347-355 http://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_home.htm