effects of low dose naltrexone on feed intake, growth, endocrine and immune parameters in the recent

OATD: Carter, Ashley Christine - Effects of low-dose naltrexone o…owth, endocrine and immune parameters in the recently-weaned pig

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Full!Record New!Search | Similar!Records Author Carter,!Ashley!Chris0ne Title Effects!of!low8dose!naltrexone!on!feed!intake, growth,!endocrine!and!immune!parameters!in the!recently8weaned!pig URL hBp://trace.tennessee.edu/utk_gradthes/3567 Publica0on!Date 2015 Degree MS Discipline/Department Animal!Science Degree!Level thesis University/Publisher University!of!Tennessee!–!Knoxville Abstract Weaning!is!a!stressful!event!for!pigs!and!causes decreased!feed!intake,!poor!growth,!and increased!suscep0bility!to!disease.!Previous studies!have!shown!that!syndyphalin833,!a synthe0c!opioid,!was!effec0ve!in!increasing!feed intake,!abroga0ng!the!changes!in!appe0te regula0ng!genes!during!weaning,!and abroga0ng!the!effects!of!a!salmonella!challenge on!immune!cells!in!newly8weaned!pigs.

However,!there!are!several!concerns!associated with!the!administra0on!of!an!opioid!in commercial!swine!opera0ons.!Low8dose naltrexone!(an!opioid!antagonist)!has!been!used to!alleviate!symptoms!from!fibromyalgia!and Crohn’s!disease!in!humans.!As!inflamma0on!is!a common!factor!in!both!auto8immune!diseases in!humans!and!weaning!stress!in!pigs,!a!logical next8step!would!be!to!examine!the!effects!of low8dose!naltrexone!on!pigs!at!weaning.!In!this study,!low8dose!naltrexone!administra0on!was evaluated!for!its!affects!on!feed!intake,!growth, endocrine,!and!immune!parameters!in!newly https://oatd.org/oatd/record?record=oai%5C%3Atrace.tennessee.edu%5C%3Autk_gradthes-4874

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OATD: Carter, Ashley Christine - Eects of low-dose naltrexone o‌owth, endocrine and immune parameters in the recently-weaned pig

1/26/16, 4:05 PM

weaned!pigs.!Four!treatments!of!0!mg/day!(d),!1 mg/d,!5!mg/d,!10!mg/d!naltrexone!were administered!orally!daily!beginning!2!wk!prior!to weaning!to!48!commercial!crossbred!pigs.!Each treatment!group!included!12!pigs.!Body!weights and!blood!samples!were!collected!d!0!and!at!1, 4,!and!7!post8weaning.!All!animals!treated!with naltrexone!had!increased!total!gain!as!compared to!the!control!animals!(P!<!0.05).!A!decrease!in feed!intake!was!seen!in!animals!treated!with!5 mg/d!naltrexone!as!compared!to!the!control animals!(P!<!0.05).!Plasma!cor0sol concentra0ons!were!similar!to!previously published!concentra0ons!and!increased!1!d post8weaning!in!the!control!animals!(P!<!0.01).

Animals!treated!with!10!mg/d!naltrexone!had higher!plasma!concentra0ons!of!cor0sol!rela0ve to!all!other!treatments!(P!<!0.01).!On!1!d!post8 weaning,!animals!treated!with!1!mg/d!and!5 mg/d!naltrexone!had!lower!plasma!cor0sol concentra0on!than!the!controls!(P!<!0.01),!and by!d!4!post8weaning,!all!animals!treated!with naltrexone!had!lower!cor0sol!concentra0ons rela0ve!to!the!control!animals!(P!<!0.01).!As!a non8opioid,!oral!low8dose!naltrexone!may!be!a promising!therapy!to!decrease!the!growth!lag associated!with!weaning.

Subjects/Keywords Animal!Sciences Contributors Cheryl!Kojima;!Henry!KaBesh,!Brian!Whitlock Country!of!Publica0on us Record!ID oai:trace.tennessee.edu:utk_gradthes84874 Repository utk8theses Date!Retrieved 2016801802 Date!Indexed 2016801802

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