Sector Landscapes: Research Tools

SECTORLANDSCAPES

RESEARCH TOOLS 2015

Leading the conversation.

SECTOR LANDSCAPES: RESEARCH TOOLS Copyright Š 2015 by LifeScience Alley. All rights reserved.

About Sector Landscapes Publications The Sector Landscapes provide in depth analysis of emerging and established industry sectors in Minnesota. The reports highlight global industry insights, Minnesota core and supporting assets, unique positioning, company lists, and industry trends. Identified sector areas include: neuromodulation, cardiac active implantables, tissue based products, research tools, animal health, diagnostics, vascular technologies, and digital health.

List of Contributors PLEASE DIRECT CORRESPONDENCE TO:

Cheryl Matter, PhD, Vice President of Research & Intelligence, LifeScience Alley cmatter@lifesciencealley.org | 952.746.3817 Emily Tubman, Market Analyst, LifeScience Alley University of Minnesota Biomedical Engineering PhD Candidate Primary Researcher & Author Bridget Wall, PhD, LifeScience Alley Consultant Secondary Researcher & Author Amanda K. Weber, Design & Research Associate, LifeScience Alley Research Visualization & Design LifeScience Alley's intelligence and research work is generously supported by our Foundational and Sustaining Members.

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About LifeScience Alley LifeScience Alley is a global leader in enabling health technology and care organizations to innovate, succeed and influence the evolution of healthcare. By influencing policy, delivering actionable information and intelligence and connecting members with critical resources, we work to ensure that Minnesota's Medical Alley remains the world's strongest health technology community.

EXECUTIVE SUMMARY The Research Tools sector in Minnesota is composed of 27 companies distributed among the following fields, with the largest proportion in the cell biology space.

+ + + +

Cell Biology (13) Instrumentation (4) Materials / Chemistry (3) Supporting (7)

The sector is bolstered by the success of R&D Systems, a mature Minneapolis-based research tools company that started in the 1970’s.

However there are a number of emerging, innovative companies that started in the 2000s.The University of Minnesota, the Mayo Clinic, and the technical workforce generated by the existing medical device and engineering industries provide an excellent talent pool of potential employees and development partners. Lastly, incubators that provide affordable wet lab and office space, as well as tax credits for R&D and angel investors, promote growth and investment in this burgeoning industry.

MINNESOTA RESEARCH TOOLS INDUSTRY GROWTH OVER 100 YEARS 1915-2015

fifteen companies

1999

ten companies

five companies

1971

[1] NATIONAL CONTEXT OF AVAILABLE RESEARCH TOOLS

1

The US is the world leader in the Research Tools sector, with revenues from the top seven companies reaching nearly $50 billion in 2014.

US RESEARCH TOOLS COMPANIES

2

[2] MINNESOTA RESEARCH TOOLS COMPANIES

5

Minnesota has twenty-seven Research Tools companies and has been growing drastically since the early 2000s.

MINNESOTA INDUSTRY

6

DEFINITIONS OF RESEARCH TOOLS COMPANIES BY CATEGORY

6

SPOTLIGHT ON R&D SYSTEMS

8

SPOTLIGHT ON EMERGING RESEARCH TOOLS COMPANIES

9

[3] INSIDE THE MINNESOTA RESEARCH TOOLS SECTOR

11

The diversity of technical expertise, concentration of incubators and new tax incentives have encouraged a robust start-up economy in Minnesota.

STATE & REGIONAL CLUSTERS OF RESEARCH TOOLS

14

TECHNICAL EXPERTISE

15

SUPPORTING INFRASTRUCTURE

18

INCUBATORS

20

TAX INCENTIVES

21

[4] MINNESOTA RESEARCH TOOLS DIRECTORY

23

LIST OF FIGURES FIGURE 1.

The Top Seven Research Tools Companies in the US

2

FIGURE 2.

Map of Minnesota Research Tools by Category

7

FIGURE 3.

Timeline History of R&D Systems

8

FIGURE 4.

Minnesota Research Tools Company Breakdown

12

FIGURE 5.

Minnesota Company Clusters

14

FIGURE 6.

NIH Awards & Funding + "IBRC" Corridor

16

FIGURE 7.

Minnesota's Biology to Engineering Spectrum

19

1. NATIONAL CONTEXT OF RESEARCH TOOLS

Text

1

Research tools companies develop products that facilitate life science research. Examples of products include cell biology products and instrumentation, analytical testing equipment and laboratory parts. The US is the world leader in research tools companies, with revenues from the top seven companies reaching nearly $50 billion in 2014. Although none of the nation’s largest research tools companies are headquartered in Minnesota, Thermo Fisher Scientific’s Product Inspection Division is located in Coon Rapids, MN, and Beckman Coulter's Immunoassay Division is located in Chaska, MN.

FIGURE 1. THE TOP SEVEN RESEARCH TOOLS COMPANIES IN THE US

"Map of United States of America with States - Outline by FreeVectorMaps.com" (page 2 and 16).

2

Sector Landscapes: Research Tools | LifeScience Alley

THE

TOP SEVEN COMPANY

HEADQUARTERS

REVENUE

EMPLOYEES

1

Thermo Fisher Scientific 1

Waltham, MA (MN operations)

$17 Billion

5000 (~120 in MN)

2

Becton Dickinson 2

Franklin Lakes, NJ

$8.4 Billion

3000

3

Beckman Coulter Brea, CA (MN operations) (Danaher Corp) 3

$6.9 Billion

24000 (~1000 in MN)

4

Agilent Technologies 4

Santa Clara, CA

$7.0 Billion

21400

5

VWR 5

Randor, PA

$4.2 Billion

8400

6

Sigma Aldrich (subsidiary of Merck) 6

St. Louis, MO

$2.7 Billion

9000

7

BioRad 7

Hercules, CA

$2.1 Billion

7750

1 SOURCE: Thermo Fisher Scientific. http://wwwthermofisher.com/en/about-us.html SOURCE: Becton Dickinson. (2014). Annual Report 2014. Retrieved from http://bd.com/ar2014/ 3 SOURCE: Danaher. (2013). Annual Report 2013. Retrieved from http://media.corporate-ir.net/media_ files/IROL/82/82105/Danaher_2013_Annual _Report.pdf 4 SOURCE: Agilent. (2014). Annual Report 2014. Retrieved from http://www.investor.agilent.com/ 5 SOURCE: VWR. (2013). Form 10-K 2013. Retrieved from http://investor.vwr.com/secfiling 6 SOURCE: Sigma Aldrich. (2013). Annual Report 2013. Retrieved from http://files.shareholder.com/downloads/SIGMA 7 SOURCE: Biorad. (2013). Annual Report 2013. Retrieved from http://www.bio-rad.com/webroot/web/pdf/ corporate/literature/Bio-Rad_2013AnnualReport.pdf 2

Section 1 | National Context of Available Research Tools

3

2. MINNESOTA RESEARCH TOOLS COMPANIES

Text

5

The Research Tools sector in Minnesota is small but growing, with a total of 27 companies occupying the space. Growth of research tools companies started in the 1970s and expanded in the 2000s, with cell biology tools companies, instrumentation companies, materials and chemistry companies and other companies that support research technology.1

DEFINITIONS OF RESEARCH TOOLS COMPANIES BY CATEGORY Cell Biology Tools Companies

Stem cells, proteins, peptides, reagents, assays and kits

Instrumentation Companies

Fluorescence plate readers and array tape

Materials / Chemistry Companies

Medical device coatings and specialty chemicals

Supporting Companies

Filter media, bioreactors, metallic and rubber parts, valves and tubing

R&D Systems, Biovest International and Lifecore Biomedical are Minnesota’s only large, public research tools companies. Other public companies that develop products that support research technology are the Donaldson Company, ATMI / Entegris and Protolabs. The majority of the research tools companies are emerging, private and small, with at least ten of the companies having 100 or fewer employees, suggesting that this is an area of growth in the life sciences.

1

6

See Research Tools Directory (p 21).

Sector Landscapes: Research Tools | LifeScience Alley

FIGURE 2. MAP OF MINNESOTA RESEARCH TOOLS BY CATEGORY

CELL BIOLOGY (13 COMPANIES) INSTRUMENTATION (4 COMPANIES) MATERIALS / CHEMISTRY (3 COMPANIES) SUPPORTING (7 COMPANIES) Text

7

SPOTLIGHT ON R&D SYSTEMS R&D (Research and Diagnostics) Systems was founded in Minneapolis in 1976 and became a public company in 1984. It is one of three major brands of Bio-Techne, which had sales of more than $350 million in 2014. The small company that started in Minneapolis now has branches in Germany, England and China; combined with Bio-Techne’s other brands, they have more than 24,000 products with 95% of them manufactured in-house.1,2 Bio-Techne’s main product lines include immunoassays, antibodies and kits. Today, the company employs more than 650 Minnesotans.

R&D Systems was the first cell biology company in what has been a growing industry in Minnesota. It paved the way for companies such as Kingfisher Biotech, Neuromics and ImmunoChemistry Technologies, employing some of these companies’ founders. “Many companies share the common history or link of R&D Systems, not only biotech companies, but even medical device companies" says Joanna LaBresh, President of Kingfisher Biotech.

FIGURE 3. TIMELINE HISTORY OF R&D SYSTEMS 2015

$357 M

Implemented new brand, Bio-Techne Acquired six new companies

2005

$190 M

1995

$50 M

Acquired Amgen and Genzyme research businesses Established R&D Systems Europe Formed Growth Factor Division

1985

Released first research reagent, TGF-beta 1 Acquired by Techne Corporation Released whole blood control with platelets Sold first hematology control

1975 1 2

8

SOURCE: Techne Corporation (2014). Form 10-K 2014. Retrieved from https://www.sec.gov/ SOURCE: R&D Systems. http://www.rndsystems.com/about_us.aspx

Sector Landscapes: Research Tools | LifeScience Alley

SPOTLIGHT ON EMERGING RESEARCH TOOLS COMPANIES Minnesota has a number of early-stage research tools companies founded in the early 2000s. Among the most innovative are Douglas Scientific, Fluorescence Innovations, Inc. and ISurTec.1,2,3 In 2014, Fluorescence Innovations, Inc. received more than $180,000 from the National Institutes of Health and from 2011 to 2013, ISurTec received more than $2,000,000 in Small Business Innovative Research (SBIR) grants.3,4 Fluorescence Innovations, Inc. has developed instrumentation that utilizes their proprietary Direct Waveform Recording Technology™ to measure the lifetime fluorescence decay, which significantly reduces noise and improves fluorescence measurements. It was founded in 2006 in Bozeman, MT, and has since moved to a new location in Minneapolis, MN. Innovative Surface Technologies (ISurTec) developed a temperature-responsive cell growth surface for the gentle, non-invasive release of cells from cultureware and microcarriers, which eliminates the need for trypsin or other harsh reagents. ISurTec was founded in 2004 and is located in St. Paul, MN.

ImmunoChemistry Technologies (ICT) provides high quality research reagents and laboratory services. ICT supplies in vitro apoptosis assays, caspase kits, fluorescent reagents for intracellular analysis and other critical detection tools to help biomedical researchers understand metabolic pathways and cure disease. ICT also offers a line of ELISA development solutions including coat buffers, conjugate stabilizers and sample diluents. As a CRO, ICT specializes in custom immunoassay development, conjugation, lyophilization and consulting services.

1 SOURCE: Douglas Scientific. http://www.douglasscientific.com/ SOURCE: Fluorescence Innovations, Inc. http://www.fluorescenceinnovations.com/ 3 SOURCE: Innovative Surface Technologies. http://www.isurtec.com/ 4 SOURCE: National Institutes of Health RePorter (2014). http://report.nih.gov/award/index.cfm 2

Section 2 | Minnesota Research Tools Companies

9

With operations in 17 countries worldwide, Douglas Scientific is a fastgrowing laboratory automation company based in Alexandria, Minnesota (two hours northwest of the Twin Cities). Their novel Array Tape速 technology has radically increased throughput of PCR reactions while simultaneously decreasing reaction volume and overall experiment cost. Their ultra-high throughput solution, Nexar速, was first utilized by agriculture companies to perform SNP genotyping on plant samples. They reinvested profits in research and development, and have adapted their technology into two smaller-scale instruments.The IntelliQube速 is the first fully automated system that integrates liquid handling, thermal cycling, detection and analysis into one instrument. It too is optimized for Array Tape and is used for both end-point and quantitative PCR applications. The other is the AmpliFire速, a point-of-use, hand held instrument that leverages isothermal chemistry to facilitate sample to answer responses in minutes. It is easily employed out in the field to test plant, animal, food and for research use in diagnostics of human samples for diseases. Most notably, the AmpliFire contributed to the global effort to address the ebola virus.

Douglas Scientific currently has 115 employees mostly based in Alexandria and a satellite office in Hopkins, MN. As demand for the Array Tape Platform continues to grow and revolutionize labs, Douglas Scientific is expanding operations in the US and international markets specially focusing on India, China and Brazil.

3. INSIDE THE MINNESOTA RESEARCH TOOLS SECTOR

CELL BIOLOGY Ancell [1] BRTI Life Sciences [2] Imanis Life Sciences [3] Immuno Biologic Lab. [4] ImmunoChemistry Tech. [5] Kingfisher Biotech [6] Lifecore Medical [7] Microbiologics [8] Mill Creek Life Sciences [9] Neuromics [10] R&D Systems [11] Surrogen [12] Verge Bio [13]

SUPPORTING Dagan Corporation [1] Donaldson Company [2] ATMI / Entegris [3] Gamma Vacuum [4] Inclined Biomedical Tech. LLC [5] Protolabs [6] Test Resources [7]

12

Sector Landscapes: Research Tools | LifeScience Alley

FIGURE 4. MINNESOTA RESEARCH TOOLS COMPANY BREAKDOWN

INSTRUMENTATION [1] Biovest [2] Fluorescence Innovations, Inc. [3] Douglas Scientific [4] iLAB LLC

MATERIALS / CHEMISTRY [1] Harland Medical [2] ISurTec [3] LKT Labs

Section 3 | Inside the Minnesota Research Tools Sector

13

STATE AND REGIONAL CLUSTERS OF RESEARCH TOOLS The majority of Minnesota research tools companies reside in the Twin Cities Metro. However, there are a handful of companies in other regions in the state, including southwest of the Twin Cities (Gibbon, Shakopee and Waconia), Rochester, Bayport, Alexandria and St. Cloud (Figure 5).

Minnesota is also part of what Greg Gillispie, President of Fluorescence Innovations, Inc. calls the Inland Biomedical Research Corridor (IBRC) that runs from the Twin Cities to Pittsburgh. Using the NIH RePORTER Tool, he compared different geographical regions in 2011 and 2012 and discovered that the top institutions in the IBRC have more funding than those in California.

"The top 12 [institutions in the IBRC] have greater National Institutes of Health funding cumulatively than the top 12 institutions in California!"

Gregory Gillispie, President of Fluorescence Innovations, Inc. Gillispie moved his company from Bozeman, Montana to Minneapolis in 2012 to capitalize on the opportunities in the region.

FIGURE 5. MINNESOTA COMPANY CLUSTERS

1 COMPANY 2 COMPANIES 3 COMPANIES

17 COMPANIES

14

Sector Landscapes: Research Tools | LifeScience Alley

TECHNICAL EXPERTISE Minnesota is home to one of the largest medical device clusters in the world, with companies such as Medtronic, St. Jude Medical, Boston Scientific and 3M either headquartered in Minnesota or with significant operations in the state.

“The advantage here is the concentration of medical device companies. There really isn’t a better place to be from that perspective.”

Eric Guire, Senior Scientist at Innovative Surface Technologies

The University of Minnesota (UMN) is a major research institution with campuses in the Twin Cities, Crookston, Duluth, Morris and Rochester.

Together, UMN-Twin Cities and UMN-Duluth received more than $300 million in federal funding from the National Institutes of Health and the National Science Foundation in 2014. The College of Biological Sciences (CBS) and the College of Science and Engineering (CSE), both on the Twin Cities campus, have 129 CBS and 430 CSE tenure and tenure-track faculty, and 2693 CSE and 313 CBS graduate students.1,2 These colleges contributed to the accolades the University recently received when it was named the 29th “Best Global University” by US News and World Report in 2014.3 Besides providing a technical workforce, the University also houses many facilities that provide access to equipment useful to research tools companies.4

SOURCE: The University of Minnesota College of Biological Sciences. http://www.cbs.umn. edu/explore/about/cbs-glance 2 SOURCE: The University of Minnesota College of Science and Engineering. http://cse.umn. edu/aboutcse/CSE_CONTENT_192612.php 3 SOURCE: US News and World Report. http://www.usnews.com/education/best-global-univer sities/rankings?page=3 4 See Research Tools Directory (p 21).

1

Section 3 | Inside the Minnesota Research Tools Sector

15

AWDS FUNDING AL

593

$273,600,407

AK

17

$10,793,647

AZ

404

$158,598,561

AR

104

$46,767,479

CA

7731

$3,499,391,307

CO

922

$313,993,551

CT

1122

$467,188,982

DE

67

$38,759,337

D.C.

380

$194,613,257

FL

1104

$476,217,118

GA

1161

$482,742,805

HI

86

$47,415,169

ID

17

$10,687,130

IL

1885

$733,227,259

IN

589

$210,731,457

IA

411

$169,772,206

KS

238

$109,462,489

KY

386

$153,050,665

LA

278

$140,203,878

ME

113

$72,949,821

MD

2296

$1,333,845,959

MA

4924

$2,404,091,828

MI

1423

$577,502,620

MN

1050

$504,952,618

MS

79

$43,166,617

MO

1073

$490,212,280

MT

67

$36,014,739

NE

218

$88,610,327

NV

45

$25,543,601

NH

203

$96,944,063

NJ

547

$246,964,069

NM

217

$96,781,115

NY

4808

$2,125,150,125

NC

2192

$1,067,282,781

ND

29

$15,893,123

OH

1564

$670,092,509

OK

174

$88,105,625

OR

673

$303,963,471

PA

3377

$1,516,874,603

84

$42,352,575

P.R. RI

439

$132,043,025

SC

422

$147,391,886

SD

36

$21,577,280

TN

1076

$466,225,823

TX

2527

$981,024,135

UT

459

$175,427,096

VT

108

$58,132,718

V.I.

3

$1,760,298

VA

770

$327,737,296

WA

1585

$906,173,368

WV

42

$18,958,353

WI

883

$386,436,340

18

$7,485,353

16 WY

Sector Landscapes: Tissue & Biologics | LifeScience Alley

FIGURE 6. NIH 2014 AWARDS & FUNDING 1 + "IBRC" CORRIDOR

1

SOURCE: http://www.report.nih.gov/award/index.cfm

SUPPORTING INFRASTRUCTURE The Mayo Clinic, with locations in Rochester, MN, Scottsdale and Phoenix, AZ, and Jacksonville, FL, received the highest honor by US News and World Report when it was named “Best Hospital in 2014/2015.”

The Mayo Clinic, Rochester received more than $203 million in funding from the National Institutes of Health in 2014 and the entire clinic has an annual research budget of more than $625 million.1,2 The Mayo Clinic has more than 200 investigators in seven academic research areas. Imanis Life Sciences, located in Rochester, MN, was founded and is currently run by Mayo Clinic professors.

“The media still does not accept Minnesota as a place for cell culture companies. We are constantly asked why we are here. When we tell them we are in Rochester, then it makes sense.”

Judy Lundy, President and COO, Mill Creek Life Sciences When asked about the workforce in Minnesota, every company president and CEO interviewed emphatically stated that it is a strength of the region.

Therefore, it is not surprising that companies (both big and small) in Minnesota span the range from cell and molecular biology to mechanical engineering, making it an ideal location for research tools companies seeking a highly-skilled technical workforce.

1 2

18

SOURCE: The National Institutes of Health RePorter (2014).

SOURCE: The Mayo Clinic. http://www.mayo.edu/mgs/programs/faculty

Sector Landscapes: Research Tools | LifeScience Alley

FIGURE 7. MINNESOTA'S BIOLOGY TO ENGINEERING SPECTRUM

R&D Systems

L CU LE MO OGY & LL BIOL

CE

Neuromics

AR

Immunochemistry Technologies

Kingfisher Biotech

Surrogen

Apogen Biotechnologies

CS MI EO ICS OT OM PR GEN &

Immunobiologic Laboratories

Biovest

Beckman Coulter

LS RIA TE CE MA CIEN S

3M

Harland Medical

ISurTec Douglas Scientific

AL DIC NG ME ERI BIO INE G EN

North Central Instruments Medtronic

Fluorescence Innovations, Inc.

Boston Scientific

L ICA AN ING CH ER ME GINE EN

St. Jude Medical

Sciencix

Protolabs Test Resources Applied Vacuum Technology

Section 3 | Inside the Minnesota Research Tools Sector

19

INCUBATORS Incubators encourage early-stage companies by providing wet-labs and office space at affordable prices, and by hosting events to bring together the life science community. The two most prominent are University Enterprise Laboratories (UEL) and the Mayo Clinic Business Accelerator, which house multiple life science companies. Both ISurTec and Kingfisher Biotech are located in UEL, where tenants individually applied for and received more than $45 million in new investments and research grants in 2013.1 Business Enterprise Center The Business Enterprise Center (BEC) is an accelerator located in Cottage Grove, MN. It offers affordable work space and support services to startups.2

Mayo Clinic Business Accelerator Based in Rochester, MN, the Mayo Clinic Business Accelerator opened in 2013 with a focus on medtech and healthtech. As of August 2015, there have been a total of 20 company tenants.3

MinnWest Technology Campus 2006 marked the founding of the MinnWest Technology Campus in Willmar, MN, a biobusiness incubator focusing on agribusiness and biotechnology. More than 30 companies currently reside as tenants (2015).2,4

The SEED Partners The SEED Partners is a newly opened biosciences incubator, accelerator and investor in the North Loop. Their 27,000 square foot space includes a 5,000 square foot wet lab facility, including fume hoods, cell culture space, and other basic & specialized life science equipment. In addition to providing shared lab and collaborative work spaces, SEED can assist clients from the early stages of an idea to product concept, as well as provide business support, office support and laboratory support services.5

University Enterprise Laboratories University Enterprise Laboratories (UEL) is a life science incubator in St. Paul, MN, with a focus on biotech, medtech and special university departments. More than 30 companies have been tenants since its opening in 2005.2,6

Worthington Biotechnology Advancement Center The Worthington Biotechnology Advancement Center is an incubator located in Worthington, MN, with a focus on agribusiness and animal health companies.2 See Research Tools Directory (p 21).

SOURCE: Leightner, Amanda. June 2015. "MN Business Incubators and Accelerators." Life

Science Nexus. Retrieved August 2015.

3 SOURCE: www.mcbusaccel.com. Retrieved August 2015.

4 SOURCE: www.mnwesttechnology.com. Retrieved August 2015.

5 SOURCE: www.theseedpartners.com. Retrieved August 2015.

6 SOURCE: www.uelmn.org. Retrieved August 2015.

1 2

20

Sector Landscapes: Research Tools | LifeScience Alley

TAX INCENTIVES To encourage innovation in the state and investment in startup companies, the State of Minnesota has implemented the R&D Tax Credit and the Angel Tax Credit.

R&D Tax Credit Eligible recipients receive a 10% credit on qualifying expenses up to $2 million, and 2.5% for expenses surpassing that amount.1

Angel Tax Credit Rewards investors 25% for investing in startups focusing on new and innovative technology.2

"The biggest advantage (of conducting my business) in Minnesota is the Angel Tax Credit. For small start-ups, this is HUGE!" Judy Lundy, President and COO, Mill Creek Life Sciences

1

SOURCE: Minnesota Revenue. http://www.revenue.state.mn.us/ 2 SOURCE: Minnesota DEED. http://mn.gov/deed/

Section 3 | Inside the Minnesota Research Tools Sector

21

IN CONCLUSION, The Research Tools sector in Minnesota is small but growing. R&D Systems, the oldest, largest and most established tools company, has paved the way for cell biology companies. Additionally, a number of companies exist that support research tools companies, such as engineering companies that develop manufactured parts. Today, there are a number of innovative companies developing tools and instrumentation to facilitate research.

Minnesota’s strong biomedical industry, academic institutions and a world-class clinic have provided training for generations of scientists and engineers that make up Minnesota’s technical workforce. Minnesota is committed to building and keeping innovative companies in-state, demonstrating its commitment by implementing programs to support research and development and early-stage venture.

With its solid infrastructure in the biosciences and engineering, programming to encourage investment in early-stage companies and recent emergence of small, private tools companies, the Research Tools sector in Minnesota is poised for growth in the upcoming decades.

CONTRIBUTORS Thank you to the company presidents, CEOs, and others who generously contributed their time and shared their perspectives on the industry: Chris Echeverri, Greg Gillispie, Eric Guire, Patrick Guire, Joanna LaBresh, Judy Lundy and Donna Pinotti.

4. MINNESOTA RESEARCH TOOLS DIRECTORY

Text

23

MINNESOTA RESEARCH TOOLS COMPANIES

24

Company

City, State

Founded Summary

Ancell

Bayport, MN

1992

Produce immunology research tools.

ATMI / Entegris

Bloomington, MN

1966

Provides products and materials used in high-technology manufacturing.

Biovest International, Inc.

Minneapolis, MN

1983

Protein manufacturing instruments utilizing proprietary hollow fiber technology.

BRTI Life Sciences

Two Harbors, MN

2003

3D- cell culture tool & matrix that creates a microenvironment for multiple applications.

Douglas Scientific

Alexandria, MN

2009

Designs and manufactures laboratory instrumentation.

Dagan Corporation

Minneapolis, MN

1974

Produces scientific instruments including voltage and cell patch clamps.

Donaldson Company

Bloomington, MN

1915

Filtration manufacturer.

Fluorescence Innovations, Inc.

Minneapolis, MN

2006

Instrumentation that measures fluorescence lifetime properties of biological systems.

Gamma Vacuum LLC

Shakopee, MN

2003

Ion pumps, titanium sublimation pumps, non-evaporable getters and their controls.

Harland Medical

Eden Prairie, MN

2003

Product solutions for healthcare surface enhancement market.

iLAB LLC

Maple Grove, MN

-

Design and development of biomedical instrumentation.

Imanis Life Sciences

Rochester, MN

2012

Non-invasive reporter systems - cell lines, lentivirus and contract imaging solutions.

Immuno Biological Laboratories

Minneapolis, MN

1997

Clinical laboratory reagent assays for research and clinical testing.

ImmunoChemistry Technologies

Bloomington, MN

1994

Protein chemistry lab. Apoptosis assays and ELISA detection reagents.

Sector Landscapes: Research Tools | LifeScience Alley

MINNESOTA RESEARCH TOOLS COMPANIES Company

City, State

Founded Summary

Inclined Biomedical Technologies LLC

Minneapolis, MN

-

Develops lab tools for academia, med / pharma, hospitals and government facilities.

Innovative Surface Technologies (ISurTec)

St. Paul, MN

2004

CRO; develops scaffolds and matrices, drug delivery and surface coatings.

Kingfisher Biotech

St. Paul, MN

2008

Research reagents for variety of species.

Lifecore Biomedical LLC

Chaska, MN

1986

Manufactures Hyaluronan and other biomaterials for various medical applications.

LKT Labs

St. Paul, MN

1988

Specialty chemicals for cancer chemoprevention.

Microbiologics

St. Cloud, MN

1971

Ready-to-use high quality lyophilized microorganisms.

Mill Creek Life Sciences

Rochester, MN

2010

Products to supplement cell culture used in stem / primary cells.

Neuromics

Edina, MN

2003

Reagents and methods for Neuroscience Research Community.

Protolabs

Maple Plain, MN

1999

Plastic injection molding parts.

R&D Systems

Minneapolis, MN

1985

Produces human cytokines for genetic engineering.

Surrogen, Inc.

St. Paul, MN

2013

Genetically-tailored large animal models of disease.

Test Resources

Shakopee, MN

1998

Materials testing equipment.

Verge Bio

Minneapolis, MN

2014

Designs and engineers diagnostic cellpermeant tracers and dyes.

Section 4 | Minnesota Research Tools Directory

25

UNIVERSITY OF MINNESOTA FACILITIES UMN Facility

Director

Summary

Characterization Facility

Greg Haugstad haugs001@umn.edu

Materials research spanning from nanotechnology to biology and medicine.

Magnetic Transport Laboratory

Dan Dahlberg dand@physics.umn.edu

Applications and advancement of Magnetic Force Microscopy (MFM).

Tissue Mechanics Laboratory

Robert Tranquillo tranquillo@umn.edu

Specialized instruments for soft biological materials.

Supercomputing Institute

Jorge Vi単als vinals@msi.umn.edu

Provides access to high-performance computing resources.

Nano Center

Steve Campbell campb001@umn.edu

Small-scale devices, nano materials and biomedical applications of nanotech.

NMR Center

Gianluigi Veglia vegli001@umn.edu

Research and education in implementation of NMR techniques to biomedical research.

Imaging Center

Mark Sanders msanders@umn.edu

Advanced optical imaging and basic electron microscopy.

MINNESOTA INCUBATORS

26

Company

City, State

Founded Summary

Business Enterprise Center

Cottage Grove, MN

-

Work space and supportive services.

MinnWest Technology Campus LLC

Willmar, MN

2006

Biobusiness incubator focusing on agribusiness and biotechnology.

Mayo Clinic Business Accelerator

Rochester, MN

2013

Collaborative space for new companies, venture capital firms and entrepreneurs.

The SEED Partners

Minneapolis, MN

-

Collaboration between business professionals & entrepreneurs in life science tech & medtech.

University Enterprise Laboratories

St. Paul, MN

2001

Collaborative research center, advancing biology and biotechnology.

Worthington Biotechnology Advancement Center

Worthington, MN

-

Focus on agribusiness & animal health companies.

Sector Landscapes: Research Tools | LifeScience Alley