New Study Identifies Certain Gut Bacteria as Potential Drivers of Lupus Flares

In a recent study, researchers investigated the relationship between gut microbiome and lupus disease activity over time. They found that growth of a particular gut bacteria, ruminococcus blautia gnavus (RG), may contribute to lupus flares.

Over a four-year period, researchers observed 16 women with lupus, and 22 women without lupus –who served as the control group. Compared to the control group, study participants with lupus were more likely to experience an increase in harmful gut bacteria, especially during disease flares. RG bacteria was detected in 40% of study participants with lupus nephritis (LN, lupus-related kidney disease), and increased during flares.

Researchers have identified a common characteristic of the RG strains that helps the bacteria adapt and multiply during flares. The most notable characteristic of these strains was the presence of a new type of lipoglycan on their cell membranes. These lipoglycans had consist- ent structures and triggered a strong immune response in the form of antibodies. lupus.org/resources/what-is-aflare

While more research is needed to fully understand the relationship between lupus and the gut microbiome, these findings will help identify biomarkers and guide future studies. Learn more about lupus flares.