8 Decades of Discovery Brochure - 2014

8 DE CAD ES OF DISOVERY G AL A DINNER 20 14

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WEI ZM A N N U K

WEIZMANN UK 9 HAMPSTEAD GATE 1A FROGNAL LONDON NW3 6AL +44 (0)20 7424 6864 POST @WEIZMANN.ORG.UK WWW.WEIZMANN.ORG.UK

8 DECADES OF DISCOVERY G A L A D I N N E R | T H U R S D AY 2 6 J U N E 2 0 1 4 SCIENCE MUSEUM

W E I Z M A N N U K I S D E E P LY G R AT E F U L T O I T S L O YA L S P O N S O R

T H E B L U S T O N C H A R I TA B L E S E T T L E M E N T FOR ITS SUPPORT OF OUR 8 DECADES OF DISCOVERY GALA DINNER

CONTENTS 02

06

36

A message from the President of the Weizmann Institute of Science, Prof. Daniel Zajfman

A message from HM Ambassador, Matthew Gould MBE

UK recognitions and dedications

07

38

A message from HE Ambassador, Daniel Taub

The Making Connections Programme

08

40

WEIZMANN UK Trustees, Ambassadors and Team

Be our guest

03 A message from the President of WEIZMANN UK, Sir David Sieff

04 A message from the Rt. Hon. Lord Rothschild,Vice President of WEIZMANN UK

05 A message from the Chairman, WEIZMANN UK, Martin Paisner CBE

09 With special thanks to ...

11 8 Decades of Discovery

42 Recent visits

46 The Personalised Nutrition Project

34 Leaving a lasting legacy

Chaim Weizmann and Israel Sieff

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8 DECADES OF DISCOVERY GALA DINNER

THE WEIZMANN INSTITUTE OF SCIENCE IS PROUD TO BE C E L E B R AT I N G 8 0 Y E A R S S I N C E ITS FOUNDING IN 1934 AS THE DANIEL SIEFF RESEARCH I N S T I T U T E , E S TA B L I S H E D W I T H A V I S I O N A R Y D O N AT I O N F R O M ISRAEL AND REBECCA SIEFF OF THE UK.

A MESSAGE FROM THE PRESIDENT OF THE WEIZMANN INSTITUTE OF SCIENCE P R O F. D A N I E L Z A J F M A N The Institute was renamed in 1949 in honour of Dr. Chaim Weizmann, who moved to Palestine from England after a career at the University of Manchester.

This great institution was his brainchild and in 1948 he became the first President of the State of Israel. In his dual role as statesman and scientist, Dr. Weizmann set in motion the wheels of the Israeli science and technology enterprise which today is the engine of Israel’s economy.

What started as a single building in the midst of Rehovot’s famed orange groves, populated by a handful of pioneering scientists, has become a world-renowned institution. The Weizmann Institute has five faculties, 17 departments, 60 donor-funded interdisciplinary centres, and a graduate school educating about a third of Israeli PhDs in science and mathematics. Today, the Institute is home to 3,000 scientists, students, and support staff.

From its earliest roots the historic contribution of UK philanthropy has nurtured the scientific powerhouse that is the Weizmann Institute. Our campus is replete with buildings named after UK founders and patrons: Sieff, Wolfson, Clore, Wix, de Botton, Siem, Ritblat, Wolff, and Lopatie. Remarkably, members of most of the founding families of the Weizmann Institute of Science are deeply involved in our International Board today, and in some cases three or more generations of leaders are engaged in the pursuit of science with us.

British roots are in our soil, and our branches grow and blossom today thanks to this deep friendship and ongoing infusion of support.

Since its formal establishment in 1950, Weizmann UK has cultivated our unique relationship with British friends.

And the results of the sustained efforts over the years have been nothing short of outstanding: UK donors have funded a dozen of our major buildings, seven major centres and institutes, no fewer than 32 professorial and career development chairs, 29 endowed scholarships and a research school. The Institute has bestowed 31 exceptional Britons with its PhDs honoris causa and five others with its Weizmann Award in the Sciences and the Humanities.

In recent years, Weizmann UK has actively promoted increased scientific cooperation between the Weizmann Institute and UK scientists. The Making Connections Programme has funded collaborative research projects between Institute scientists and their counterparts at leading UK academic institutions. And this is just one example of how the investment and involvement of UK friends is shaping the Weizmann Institute and, more broadly, modern science for the benefit of humanity.

I offer my profound thanks and gratitude to all who celebrate this important milestone with us.

Sincerely,

Prof. Daniel Zajfman President, Weizmann Institute of Science Rehovot June 2014

02

A MESSAGE FROM THE PRESIDENT OF WEIZMANN UK SIR DAVID SIEFF The 8 Decades of Discovery that we’re celebrating tonight, started with an ambitious letter from my grandfather, Israel Sieff, to Chaim Weizmann. It crystallised some conversations they’d been having about the aims of what was then to be The Daniel Sieff Research Institute.

In today’s language, it might be called a mission statement.

The letter was dated March 1934. In a very simple way it set out to define the ethos that was to direct the Institute’s work then, and has continued ever since.

In those 80 extraordinary years which saw the birth and flourishing of the State of Israel and its amazing intellectual achievements, the Weizmann Institute has grown into one of the world’s great scientific institutions – part of the nation’s richly innovative culture.

Chaim Weizmann originally wanted the Institute to investigate the problems of agriculture. My grandfather’s letter went further. “I want this striving for practical achievement,” he wrote, “to be accompanied by the discovery of knowledge for its own sake… for its fruit-bearing qualities and its light-bearing qualities.”

My grandfather’s letter had something more to say.

Instead of narrow and exclusive nationalism, he wrote, “we should contribute our quota to the advancement of all human knowledge and social advancement.”

That’s a message that remains as relevant today as it was eighty years ago. Science for the benefit of humanity.

It makes me proud to be part of this great undertaking and I’m sure that you will share that pride.

Thank you all for joining us this evening and sharing the celebration of these extraordinary 8 Decades of Discovery.

Sincerely,

Sir David Sieff President, Weizmann UK June 2014

That has remained a quintessential component of the Institute’s approach. Asking questions that no-one has thought to ask, to quote our current Institute President, Professor Daniel Zajfman. A quest driven by curiosity.

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8 DECADES OF DISCOVERY GALA DINNER

“I M M E A S U R A B L E

C O N G R AT U L AT I O N S T O T H E S I E F F FA M I LY O N T H E O C C A S I O N OF THE 80TH ANNIVERSARY OF THE DANIEL SIEFF RESEARCH INSTITUTE.

”

T H E R T. H O N . L O R D R O T H S C H I L D

A MESSAGE FROM T H E R T. H O N . L O R D R O T H S C H I L D V I C E P R E S I D E N T, W E I Z M A N N U K CHAIM WEIZMANN ONCE SAID “MIRACLES DO HAPPEN BUT ONE HAS T O W O R K V E R Y H A R D F O R T H E M .”

The miracle of the Weizmann Institute continues and I saw for myself, just the other day, the extraordinary developments which are taking place in personalised medicine.

Immeasurable congratulations to all concerned, and in particular the Sieff family on the occasion of the 80th anniversary of the Daniel Sieff Research Institute. Ever since this Institute was founded in 1934, members of the Sieff family – from David’s grandfather Israel, to his father Marcus and now David – have given their passionate and inspirational support to the Institute.

The Rt. Hon. Lord Rothschild Vice President, WEIZMANN UK June 2014

04

A MESSAGE FROM THE CHAIRMAN OF WEIZMANN UK M A R T I N PA I S N E R , C B E

Chairman, WEIZMANN UK June 2014

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8 DECADES OF DISCOVERY GALA DINNER

A MESSAGE FROM HM AMBASSADOR M AT T H E W G O U L D , M B E

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A MESSAGE FROM HE AMBASSADOR OF ISRAEL D A N I E L TA U B

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8 DECADES OF DISCOVERY GALA DINNER

TRUSTEES AMBASSADORS PRESIDENT The Hon. Sir David Sieff

VICE PRESIDENTS Lord Alliance CBE Lord Mitchell Sir John Ritblat Lord Rothschild Barry Townsley CBE

WEIZMANN UK TRUSTEES Martin Paisner CBE Chairman

Dame Vivien Duffield DBE Vice Chairman

Jeremy Smouha Vice Chairman

Jonathan Kropman Honorary Secretary

Howard Stanton FCCA Honorary Treasurer

Elissa Bayer Professor Benny Chain Julian Dwek Maxwell Nisner Denis Raeburn Michael Sandler Daniel Shapiro Greg Swimer Barry Townsley CBE Lord Turnberg Myra Waiman

08

WEIZMANN UK AMBASSADORS

WEIZMANN UK TEAM

Ann Berger Janet Bloch Dr Judy Dangoor David Dangoor The Hon. Deborah Wolfson Davis The Hon. Janet de Botton Fiona Fattal Daniel Gestetner Jonathan Gestetner David Grunberg Professor Herbert Huppert FRS Philip Joseph Allyson Kaye Oliver Levy Dr Hilda Lewis Lady Lowy-Mitchell Selina Marks David Marks Martin Mendoza Jonathan Metliss Lady Michels Paul Morris OBE The Hon. Elizabeth Peltz Robert Perlman Arlene Seaton Roger Seaton Lady Sieff The Hon. Amanda Sieff The Hon. Daniela Sieff Cathy Wills The Hon. Laura Wolfson Townsley

Sheridan Gould Executive Director

Benjamin Morrison Deputy Director

Nicole Barnett Zila Golbert Natasha Grunberg Jo Silverman Carmel Spyer Lydia Wood

WITH SPECIAL THANKS TO OUR WONDERFUL SUPPORTERS O U R T I T L E S P O N S O R : T H E B L U S T O N C H A R I TA B L E S E T T L E M E N T P L AT I N U M TA B L E H O S T S

S I LV E R TA B L E H O S T S

Miel de Botton

Elissa Bayer, Investec Wealth and Investment

AND THANKS TO THOSE WHO MADE THIS EVENING SO SPECIAL

Berwin Leighton Paisner LLP

Miel de Botton

The Chain Family

Blake Ezra Photography

Jacqueline & Jonathan Gestetner

Gideon Chain - Ambie.fm

Philip Moross

Louise & David Grunberg

The Community Security Trust

Laura Wolfson Townsley & Barry Townsley CBE

Philip Joseph

Energy Design Studio

Oliver Levy

Fisher Productions Ltd

Rochelle & Maxwell Nisner

HM Ambassador Matthew Gould MBE

Rothschild Private Management Ltd

Professor Eran Segal

Gail & Michael Sandler

The Hon. Amanda Sieff

Charles Wolfson Townsley

Lady Sieff

Dr Arabella Duffield Denitza & Julian Dwek Dr Hilda Lewis, Robert Lewis & Cathy Wills

Elizabeth & Daniel Peltz Sir David & Lady Sieff Sabine & Jeremy Smouha

G O L D TA B L E H O S T S Lady Michels Denis Raeburn Sir John & Lady Ritblat Ellen & Dan Shapiro

HE Ambassador Daniel Taub Tony Page Ltd

P roduction Editorial and archive research: Sheridan Gould Design: Janet White Energy Design Studio

ADDITIONAL THANKS FOR ALL THE MESSAGES OF SUPPORT AND TO E V E R Y O N E W H O H A S G E N E R O U S LY D O N AT E D T O T H I S E V E N T B U T W E R E U N A B L E T O AT T E N D .

Brochure messages: Lydia Wood With special thanks to: Tamar Morad, Heidi Shulman, Andrea Shveika and Sima Tamir of the Weizmann Institute of Science

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8 DECADES OF DISCOVERY GALA DINNER

“M I R A C L E S D O HAPPEN BUT YOU HAVE TO WORK HARD AT T H E M

1921

”

Albert Einstein and Chaim Weizmann on a fundraising visit to New York

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8 DECADES OF DISCOVERY

THE WEIZMANN INSTITUTE OF S C I E N C E I S P R O U D T O B E C E L E B R AT I N G 80 YEARS SINCE ITS FOUNDING IN 1934 AS THE DANIEL SIEFF RESEARCH I N S T I T U T E , E S TA B L I S H E D W I T H A V I S I O N A R Y D O N AT I O N F R O M I S R A E L AND REBECCA SIEFF OF THE UK.

Rebecca and Israel Sieff

“

THE INSTITUTE IS THE FULFILMENT OF A VISION A N D T H E T R A N S L AT I O N O F A D R E A M I N T O R E A L I T Y. IT CAN ACHIEVE MUCH FOR THE GOOD OF OUR NEIGHBOURS AND FOR THE GOOD OF MANKIND. DR. CHAIM WEIZMANN

”

F I R S T P R E S I D E N T O F T H E S TAT E O F I S R A E L FIRST PRESIDENT OF THE WEIZMANN INSTITUTE OF SCIENCE

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8 DECADES OF DISCOVERY GALA DINNER

THE WEIZMANN INSTITUTE OF SCIENCE, A VIBRANT SCIENTIFIC RESEARCH CENTRE, B E G A N I T S E A R LY L I F E M O D E S T LY A S THE DANIEL SIEFF RESEARCH INSTITUTE. IT WAS FOUNDED IN 1934 BY ISRAEL AND REBECCA SIEFF FROM THE UK IN MEMORY OF THEIR SON DANIEL.

F O U N D AT I O N S OF A WORLD-CLASS INSTITUTION

Israel Moses Sieff 1889-1966 portrait by Zvi Oppenheim

12

Rebecca Doro Sieff 1890 -1966 portrait by Landau

1930

Daniel Haim Sieff 1916 -1933 artist unknown

Dr. Chaim Weizmann with Institute staff

1933 Drawing of the Daniel Sieff Research Institute by B.Chaikin FRBA

1934

IT WAS RENAMED AND F O R M A L LY D E D I C AT E D AS THE WEIZMANN INSTITUTE OF SCIENCE ON 2ND NOVEMBER, 1949.

DR. CHAIM WEIZMANN, ZIONIST LEADER AND THE FIRST PRESIDENT O F T H E S TAT E O F I S R A E L , WHO WAS A CHEMIST

BY TRAINING, WAS THE VISIONARY BEHIND T H E E S TA B L I S H M E N T O F THE INSTITUTE, AS WELL A S I T S F I R S T P R E S I D E N T.

1938 Institute scientists applied fermentation techniques developed

by Dr. Weizmann to such materials as orange and grapefruit peels to create useful chemical compounds for the local citrus industry. They found that fennel and anise oils contain compounds that were chemically similar to the hormone estrogen, and proposed them as a source of synthetic estrogen.

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8 DECADES OF DISCOVERY GALA DINNER

1940

D U R I N G T H E 1 9 4 0s T H E D A N I E L S I E F F R E S E A R C H I N S T I T U T E launched T H E F I R S T C A N C E R R E S E A R C H PROGRAMME IN ISRAEL. THE INSTITUTE PRODUCED MUCH-NEEDED MEDICINES, PAINKILLING DRUGS, S E D AT I V E S A N D A N T I - M A L A R I A L P R E PA R AT I O N S .

1940 Institute scientists advanced the refining process of petroleum by devising methods to create higher-octane fuel. Separately, Institute research also led to a method for producing a type of synthetic rubber that was cheaper than natural rubber and more durable than other alternatives in the market.

1944 Rebecca and Israel Sieff visit the Institute

1941 During WWII, Institute scientists adapted their research to the creation of drugs and other substances that had been imported to Mandatory Palestine from Germany, such as quinine substitutes for treating malaria. Another drug to come out of Institute labs at that time was Evipan, a barbiturate-based painkiller.

The early war years were marked by a dramatic growth spurt in chemistry research that led to the invention of 22 new compounds.

Hannah and Michael Marks Memorial Laboratory

14

1949 The Daniel Sieff Research Institute becomes the Weizmann Institute of Science, and its activities expand to cover four additional fields of research beyond biochemistry and organic chemistry: isotope research led by Prof. Israel Dostrovsky, polymer research led by Prof. Aharon Katzir, biophysics led by Prof. Ephraim Katzir, later the President of the State of Israel, and applied mathematics led by Prof. Haim Pekeris.

Chemist Prof. Israel Dostrovsky and mathematician Prof. Joseph Gillis planned and constructed a unique apparatus called a ‘distilling column’ that was able to separate isotopes.

Oxygen isotopes produced by this device were then used for research in chemistry, physics, biology, and medicine, including studies in nutrition and neurodegenerative diseases. The distilling column was used mainly for production for export and for many years it supplied most of the world’s demand for heavy oxygen.

At a gathering held after sports demonstrations at the Institute.

Sitting on chairs.... Meyer Weisgal, Rebecca Sieff, Dr. Chaim Weizmann

15

1953

8 DECADES OF DISCOVERY GALA DINNER

PhD HONORIS CAUSA RECIPIENTS FROM THE UK SIR ROBERT ROBINSON

ISRAEL SIEFF REBECCA D. SIEFF

SIR ERNST B. CHAIN

1955

SIR ERNST B. CHAIN

SIR CHRISTOPHER INGOLD S I R I S A A C W O L F S O N , B A R T. LORD MARKS OF BROUGHTON

R ebecca D . S ieff

1955

1953 1953 1955 1955 1958 1959 1959

1959

I srael S ieff

1959

S ir I saac W olfson , B art .

1953 Sir Isaac and Lady Edith Wolfson

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L ord M arks of B roughton

1954 The WEIZAC (Weizmann Automatic Computer) was the first computer in Israel and the Middle East and one of the first large-scale electronic computers in the world.

1953 The Isaac Wolfson building above and the Edith Wolfson Residence below

1950 1956 Seder at the Weisgals. Julian Meltzer, Anna Wix, Janet Wix (Bloch), Meyer Weisgal, Michael Wix, Shirley Weisgal, Ethel Wix

1958 The Wix Building

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8 DECADES OF DISCOVERY GALA DINNER

1963 Institute scientists contributed to the understanding of the internal structure of atomic nuclei, and were integral in developing calculations that help project the levels of nuclear energy in different conditions of the atom.

1967, The Hon. Marcus Sieff, Meyer Weisgal and David Ben-Gurion

1969

PROFESSORIAL CHAIRS AND CAREER DEVELOPMENT CHAIRS FROM UK DONORS

1962

1960 The Rebecca and Israel Sieff Chair of Organic Chemistry 1960

The Charles and David Wolfson Professorial Chair of Theoretical Physics 1965

The Agnes Spencer Chair of Physical Chemistry 1965

The Harry and Abe Sherman Chair of Physical Chemistry 1966

The Garfield Weston Chair of Immunology 1966

18

lord rothschild

S ir C harles C lore

PhD HONORIS CAUSA RECIPIENTS FROM THE UK

1962 1962 196 7 196 9 196 9

HARRY SACHER LORD (VICTOR) ROTHSCHILD THE HON. MARCUS SIEFF SIR JOHN C. KENDREW SIR CHARLES CLORE

1964 The Charles Clore International House

1964 The Youth Activities Section started in 1964 to enrich the education of science-oriented youth with extracurricular programming.

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8 DECADES OF DISCOVERY GALA DINNER

1965 Responding to the challenge of reducing the then-exorbitant cost of synthesizing antibiotic and other drug compounds on an industrial scale for therapeutic use, Institute scientists developed a range of chemically active polymers that are used for the preparation of various substances, thus lowering the production cost of antibiotics.

1960

1965 Meyer Weisgal, Sir Isaac and Lady Edith Wolfson with Prof.Yitzhak Birnbaum look at drawings for a new building for experimental biology

1966 A long-time private residence of Sir Isaac Wolfson was gifted to the Weizmann Institute

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1966 Anna Wix at the dedication of the Michael and Anna Wix residences

1967 The Barnett Shine residence gifted to the Weizmann Institute of Science

1968 Institute scientists developed a method called the “Consistent Force Field” for calculating the forces exerted within a molecule.

This method makes it possible to elucidate the structure of molecules, as well as to calculate the binding energy of their components. This work served as the foundation for Prof. Warshel’s research in computer modeling of chemical reactions for which he was awarded the Nobel Prize in Chemistry in 2013.

1968 Lady Edith Wolfson opens the Wolfson Building of Experimental Biology

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PhD HONORIS CAUSA RECIPIENTS FROM THE UK

1972 197 7 197 7 1979

1 9 77

8 DECADES OF DISCOVERY GALA DINNER

SIR HANS A. KREBS SIR SIEGMUND WARBURG HAROLD WILSON DERRICK KLEEMAN

1970

H arold W ilson

E S TA B L I S H E D T H E F I R S T A C C E L E R AT O R F O R T H E S T U D Y O F AT O M I C N U C L E I I N I S R A E L .

SCHOLARSHIPS AND POSTDOCTORAL FELLOWSHIPS The Jack and Simon Djanogly Scholarships 1971

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PROFESSORIAL CHAIRS AND CAREER DEVELOPMENT CHAIRS FROM UK DONORS The Samuel Sebba Professorial Chair of Pure and Applied Physics 1972

The Hella and Derrick Kleeman Chair of Biochemistry 1979

1971 Yeda (the technology transfer arm of the Institute) filed the first patent for what later became the blockbuster drug Copaxone速 for the treatment of multiple sclerosis.

It was licensed to Teva Pharmaceuticals in 1987 and has been its best-selling drug since. Copaxone was developed over three decades by Prof. Michael Sela, Prof. Ruth Arnon and Dr. Dvora Teitelbaum, and is considered one of the great successes in knowledge transfer in Israeli scientific history.

1976 Golda Meir with Arabella and George Duffield

1972 Bessie Lawrence Summer School

1976 Meyer Weisgal, Golda Meir,Vivien Duffield and Sir Charles Clore at the opening of the refurbished Weizmann House

1977 Jeni and David Sieff and Sir Marcus Sieff

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8 DECADES OF DISCOVERY GALA DINNER

PhD HONORIS CAUSA RECIPIENTS FROM THE UK

1985 198 7 19 88

VIVIEN CLORE DUFFIELD

SCHOLARSHIPS AND POSTDOCTORAL FELLOWSHIPS Sir Charles Clore Postdoctoral Fellowships

SIR JAMES LIGHTHILL

1980

LORD WOLFSON OF MARYLEBONE

Norman Sosnow Postdoctoral Fellowship

V ivien C lore D uffield

1988

1985

1984

Dr. Esther Hellinger Memorial Scholarship 1986

L ord W olfson O f M arylebone

PROFESSORIAL CHAIRS AND CAREER DEVELOPMENT CHAIRS FROM UK DONORS The Sir Ernst B. Chain

1980

Professorial Chair of Immunology 1980

The Jack and Simon Djanogly Chair of Computer Sciences 1980

The Peter and Carola Kleeman

Weizmann Institute scientists developed new wheat varieties that provide a 40 percent higher yield, allowing for greater wheat production per growing area unit.

These high-yielding “super-crops” are nutritious and environmentally friendly, more resistant to diseases, competitive with weeds, efficient in mineral and water consumption, and able to perform well under conditions of environmental stress. They also developed a type of corn that is resistant to witchweed (Striga), which historically devastated crops throughout Africa, and developed other crops that are resistant to parasitic weeds. The use of these new strains led to a tripling of crops in places like Kenya and Uganda.

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Chair of Biochemistry 1983

The Sir Siegmund Warburg Chair of Agricultural Molecular Biology 1983

Chair of Optical Sciences 1980

The Harry Kweller and Kathleen Kweller

The Pauline Recanati Career Development

Professorial Chair of Condensed Matter Physics 1984

Chair in Immunology 1980

1980

The Jack and Simon Djanogly

The Elaine Blond Career Development Chair in Perpetuity 1981

The Judith Kleeman Chair 1981

The Gilbert de Botton Chair of Plant Sciences 1981

The Dr. Hymie Moross Chair of Molecular Immunology 1981

The Margaret Thatcher Chair of Chemistry 1985

The Philip Harris and Gerald Ronson Career Development Chair 1986

The Raymond Burton Prize to support UK Endowed Professorial Chairs 1986

The Siegmund and Henny Gestetner Career Development Chair 1989

198 3 Weizmann scientists elucidate the role of the tumor suppressor protein p53, showing that it actively prevents cancer. It has since been found that p53 is dysfunctional in almost all cancer types. It is the most-studied protein in cancer research.

1985 Prof. Michael Sela,Vivien Duffield, Marcus Sieff, Sara Sela and Lily Sieff

T he first to build an advanced solar energy research comple x that is still one of only a handful in the world .

1986 Margaret Thatcher at the Weizmann Institute

1988 Weizmann scientists discover the synergistic effect of combining an antibody-based therapy and conventional chemotherapy in treating certain types of aggressive cancer. This discovery led to the development of Erbitux, now used to treat colorectal and head and neck cancers.

1989 Derrick Kleeman and Henny Gestetner

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8 DECADES OF DISCOVERY GALA DINNER

1992 The Baroness Thatcher of Kesteven receiving her PhD honoris causa from Institute President Prof. Haim Harari UK delegation at the honorary PhD Ceremony for Margaret Thatcher.

Stanley Cohen, Martin Mendoza, Sir David Sieff, Sir John Ritblat, Peter Wiegend, Jonathan Metliss

1990

S C I E N T I S T S C R E AT E A N A N O - S C A L E R E S E A R C H F A C I L I T Y F O R S O P H I S T I C A T E D E L E C T R O N I C D E V I C E S.

1992 Prof. Reshef Tenne and Prof. Gary Hodes created a new nanomaterial, Tungsten Disulfide (WS2), that has unique physical properties; translated into use as industrial lubricants, it enables far greater efficiency in reducing wear and tear on machinery.

26

1992 Ivor Levene and Sir David Sieff at the dedication of the Sir John Ritblat House at the Youth Village

SCHOLARSHIPS AND POSTDOCTORAL FELLOWSHIPS Martin and Dianne Mendoza Scholarship 1991

Wolfson Postdoctoral Scholarships 1991

Reuff Wormser Postdoctoral Scholarship Fund 1992

Wolfson Scholarships for Russian Students 1993

Elias and Hilda Sofaer Scholarship

1994 Dr. Chaim Weizmann’s Laboratory refurbished following a gift by Edna and Mandy Moross

1994

Rixi Markus Scholarships in Memory of Eugenia, Ignacy and Herbert Alfred Heller 1995

Sir David Sieff PhD Scholarship in Brain Research 1997

Kitty Waas Dekker, Simon Waas and Rosette Dekker Scholarship 1998

Lily Sieff Doctoral Scholarship 1998

Marcus & Lily Sieff Postdoctoral Fellowship 1998

J. Stanley Weyman Memorial Scholarship 1998

Rita Gehl Scholarship in Cancer Research 1999

1996 Gift-giver Dame Vivien Duffield gets a gift as a tribute to her lifetime involvement with the Weizmann Institute of Science

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PhD HONORIS CAUSA RECIPIENTS FROM THE UK

199 0 199 0 199 0 199 2

SIR DAVID C. PHILLIPS N. AVRION MITCHISON HENNY GESTETNER T H E B A R O N E S S T H A T C H E R OF KESTEVEN SIR DAVID SIEFF SIR AARON KLUG

1998

MANDY MOROSS

1990

199 3 199 6 199 8

1990 PROFESSORIAL CHAIRS AND CAREER DEVELOPMENT CHAIRS FROM UK DONORS The Maxwell Ellis Professorial Chair in Biomedical Research 1997

HENNY GESTETNER

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MANDY MOROSS

1993

1995

Lord Marcus Sieff, Sir David Sieff and Murray Koffler

Prof. Moty Heiblum and his colleagues produced the world’s purest semiconductor. It is based on a material called Gallium Arsenic (GaAs), which allows free-flowing electrons to move great distances with no collisions with pollutants, enabling major advancements in the semiconductor industry.

1996 Prof. Sir Aaron Klug FRS, Nobel Prize in Chemistry

Prof. Moshe Shapiro developed the so-called ‘coherent control’ method for controlling chemical reactions with light by applying principles of quantum mechanics to enable laser light to selectively interfere with molecular waves – thus enhancing or suppressing chemical reactions.

This work has become a standard technique, leading to the creation of numerous applications including ultra-fast electronic switches and methods of directing current in semiconductors.

1998 Prof. Haim Harari with Dame Vivien Duffield at the Clore Garden of Science

1999 The Davidson Institute of Science Education was established. It brought Youth Science Education under one roof, and has since become a model for a model for advancing science literacy. Today, more than 70 programmes serve 500,000 children every year.

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2000

2002

A team led by Prof. Eytan Domany designed a unique algorithm for analysing genetic data that involves ‘clustering’ information into relevant categories of similar genes – a major step in the blossoming field of bioinformatics towards advancing personalised medicine.

Gilbert de Botton Building.Yeda Research and Development Ltd.

PROFESSORIAL CHAIRS AND CAREER DEVELOPMENT CHAIRS FROM UK DONORS The Simon Weinstock Professorial Chair of Astrophysics 2000

The Harry Weinrebe Professorial Chair of Laser Physics 2000

The Hilda and Cecil Lewis Professorial Chair of Molecular Genetics 2001

2000

E S TA B L I S H E D A N I N T E G R AT E D S TAT E O F T H E A R T P R E - C L I N I C A L RESEARCH FACILITY WITH THE MOST ADVANCED BIO-IMAGING TECHNOLOGIES. PhD HONORIS CAUSA RECIPIENTS FROM THE UK

2003 2004 2005 2009

S I R M I C H A E L V. B E R R Y SIR ALAN R. FERSHT S I R H A R R Y D J A N O G LY HILDA LEWIS 2009

Profs. Ron Naaman, David Cahen, and Abraham Shanzer invented tiny sensors based on organic molecules that can detect pollutants in water, airborne toxins, and traces of hidden explosives potentially used in terror attacks. The sensors can detect miniscule amounts of substances – as little as just a few hundred molecules. They have a vast spectrum of applications including diagnosing asthma and preventing terror attacks.

2005

2001

The Harry Weinrebe Professorial Chair of Computer Science and Biology 2005

The Linda Jacobs Chair of Immune and Stem Cell Research 2006 S ir H arry D janogly

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H ilda L ewis

SCHOLARSHIPS AND POSTDOCTORAL FELLOWSHIPS Anna Galeski Scholarship 2000

The Daniel Falkner Scholarship 2001

Prof. Arthur Charlesby Fund for Doctoral Student Scholarships and Travel Stipends 2001

2002

2004

Prof. Adi Shamir was awarded the A.M. Turing Award for developing the RSA cryptosystem in the 1970s, together with his colleagues Ron Rivest and Leonard Adleman of MIT. The technology is the basis for Internet security, smart-cards that encode satellite television broadcasts, and online banking.

Prof. Ehud Shapiro designed a tiny computer made entirely of biological molecules which was programmed – in a test tube – to identify molecular changes in the body that indicate the presence of certain cancers, diagnose the specific type of cancer, and produce a drug molecule that causes the cancer cell to self-destruct.

2003

2006

Prof. Lucio Frydman developed a new approach to nuclear magnetic resonance (NMR) whereby all measurements from images can be performed at once, and completed within a fraction of a second. This method is being further developed for commercial and scientific use.

Prof. Nava Dekel, together with doctors in the in vitro fertilization (IVF) unit of the Kaplan Medical Center, make the surprising discovery that performing a uterine biopsy in which a slight injury is caused to the lining of the uterus just before a woman undergoes IVF doubles the chances of a successful pregnancy. This method is now being used as standard protocol worldwide.

The FDA approved a non-invasive, MRI-based method for breast and prostate cancers, called Three Time Point (3TP), invented by Prof.

Hadassa Degani. The technique produces an image of blood vessels supplying cancerous tumors with oxygen, making it possible to distinguish between malignant and normal tissues.

The Arthur Konviser Memorial Scholarship in Cancer Research 2007

The Sabine and Jeremy Smouha Scholarship 2007

The Michael Jacobs MDs for PHD Scholarship 2007

The Ada Moross Scholarship 2008

The Richard and Christine Purchas Scholarship 2008

2009 Prof. Ada Yonath is awarded the Nobel Prize in Chemistry in 2009 in acknowledgment of her four decades of work deciphering the structure and mechanism of action of the ribosome, the cell’s protein factory.

2001 Daniel Falkner

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MARTIN D. PAISNER (CBE)

2013

2 0 11

2 0 11

8 DECADES OF DISCOVERY GALA DINNER

M U R R AY P E R A H I A

D A V I D L O PAT I E

2010

PROFESSORIAL CHAIRS AND CAREER DEVELOPMENT CHAIRS FROM UK DONORS The Edith and Nathan Goldenberg Career Development Chair 2010

The Marketa and Frederick Alexander Professorial Chair 2012

PHD HONORIS CAUSA RECIPIENTS FROM THE UK

2 011 2 011 2 013

2011 The David Lopatie International Conference Centre

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MARTIN D. PAISNER CBE M U R R AY P E R A H I A D AV I D L O PAT I E

2012 Prof. Shafi Goldwasser wins the A.M. Turing Award with her long-time colleague, Prof.

Silvio Micali of MIT, for their groundbreaking work on cryptography. In addition to their development of a ‘zero knowledge proof,’ the two also developed the concept of ‘probabilistic encryption,’ which is universally credited as changing cryptography from an ‘art’ to a ‘science’. This concept, first published in 1982, now serves as the foundation of modern-day encryption methods.

Prof. Irun Cohen’s discovery of a peptide involved in the immune process leading to type 1 (juvenile) diabetes led to the development of the drug DIAPEP277, which was approved by the FDA for use in 2012 after it showed to be effective in halting the progression of the disease.

Thousands of physicists from 65 countries including a team from the Weizmann Institute led by Profs. Giora Mikenberg and Eilam Gross, prove the existence of the Higgs Boson, an elementary particle which served as the ‘missing piece’ of the Standard Model of particle physics. The discovery was made at the LHC particle accelerator in CERN, Switzerland.

Prof. Michal Schwartz and her team developed a transformational treatment to repair traumatic damage in the spinal cord and the central nervous system, using a combination of laser light and nerve growth factors extracted from fish.

2013 The Nancy and Stephen Grand Israel National Center for Personalized Medicine was established, providing Israeli science and industry with state-of-the-art research platforms in genomics, protein profiling, bioinformatics, and drug discovery.

British Ambassador to Israel, Matthew Gould and President Shimon Peres at Weizmann House

SCHOLARSHIPS AND POSTDOCTORAL FELLOWSHIPS Postdoctoral Fellowship in memory of Mr. Macdonald Leapman 2012

Denis Raeburn Scholarship 2013

Prof Daniel Zajfman with Laura Wolfson Townsley and Dr Berta Strulovici

David and Emma Wachtel Scholarship Fund 2013

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8 DECADES OF DISCOVERY GALA DINNER

LEAVING A LASTING LEGACY W E PAY T R I B U T E T O T H E M A N Y U K I N D I V I D U A L S W H O C H O S E T O P E R P E T U AT E T H E I R L I F E L O N G I N T E R E S T S A N D VA L U E S B Y I N C L U D I N G T H E W E I Z M A N N I N S T I T U T E OF SCIENCE IN THEIR WILL. HERE ARE JUST A FEW SNAPSHOTS OF THESE REMARKABLE PEOPLE WHO W I L L A L W AY S B E R E M E M B E R E D A S S O M E O N E W H O R E A L LY M A D E A D I F F E R E N C E .

Nathan Goldenberg 1911-1995 Edith Goldenberg 1913-2010

Nathan Minzly 1921-2011

Edith and Nathan Goldenberg (left) with Lord and Lady Sieff

Nathan Minzly (second from right) with Prof. Daniel Zajfman and Sheridan Gould on his last visit to the Institute

Nathan and Edith Goldenberg were committed to supporting the State of Israel. As the chief food technologist at Marks and Spencer Nathan reported to Marcus Sieff. He played a significant role in revolutionising the food production industry both in the UK and Israel.

It is fitting that the bequest made by the Goldenbergs has been directed to support a Career Development Chair in the area of plant science.

Philip and Lynda Goldenberg

34

“

The Nathan Minzly Alternative Energy Fund was established in 2012 in recognition of a munificent bequest from the estate of Nathan Minzly. Nathan had been a committed supporter throughout his life and had a keen interest in the Institute’s solar energy research programme. It is fitting that this fund will enable scientists to pursue research to seek new sources of energy that will benefit generations to come.

I CAN THINK OF NO BETTER CAUSE T H A N T H AT O F T H E W E I Z M A N N INSTITUTE, WITH ITS STRAPLINE SCIENCE FOR THE BENEFIT OF H U M A N I T Y. W H AT B E T T E R L E G A C Y IS THERE FOR OUR CHILDREN AND OUR GRAND CHILDREN. A R L E N E S E AT O N AMBASSADOR, WEIZMANN UK

”

Marketa Alexander 1917-2010

Marketa Alexander left a generous bequest to the Weizmann Institute of Science. Her bequest has been directed to support a Professorial Chair.

The current incumbent is a cancer research scientist Prof. Atan Gross. We remain grateful to the executors of her estate Dr Euan Campbell, Betty and Stephen Litchfield and Stephen Rajbenbach for their stewardship of Marketa’s generous gift.

David Barton 1941-2008

The Weizmann Institute is where your philanthropy can transform life’s success into a future that is bright with hope for mankind. David Barton, a lifelong collector of ‘Premium Quality’ postage stamps left an extraordinary collection in his estate which was sold at Sotheby’s for a significant sum. David will be remembered as someone who really made a difference.

Judy & David Lever at the International Donor Wall

Macdonald Leapman 1919-2009

Macdonald Leapman had a long association with the Weizmann Institute. It was while serving as a Royal Air Force pilot out of Egypt in the ‘40s that he first met Chaim Weizmann, whose bold vision of conducting research in the desert sands of Rehovot left a lasting impression on the young man. Macdonald’s legacy managed by the Executor of his Estate, Harvey Rose which now provides the funding for a graduate scholarship that is named in perpetuity in his honour.

Harvey Rose visiting the International Donor wall

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8 DECADES OF DISCOVERY GALA DINNER

1989

Derrick and Hella Kleeman

1999

Clore Prize Winner Dr. Naama Barkaia

1998

Philip Harris dedication

2004

Curwen-Lowy Biological Studies Fellowship Dr. Irna Lavelin and Lord Mitchell

2001

Dwek Family dedication

2004

Clore Prize Winner Dr. Ian Lampl

UK RE AND D

2006 Prof. Ronen Alon with the late Michael Jacobs at the dedication of the Linda and Michael Jacobs Chair in Stem Cell research

2007 Hilda and Robert Lewis

2007

Lord and Lady Mitchell with Elizabeth and Ashley Mitchell at the dedication of the Rose and Leon Laboratory

2010

Robert Lewis and Prof. Dan Yakir

2008

Maurice and Solo Dwek at the dedication ceremony of the Dwek School of Chemical Science

2010

Clore Prize Winner Dr. Jacob Hanna

2012

2012

David and Judy Dangoor at the dedication of the Dangoor Research Accelerator Mass Spectrometry (D-REAMS) Laboratory

Prof. Daniel Zajfman, Dr. Arabella Duffield, Larry Blumberg

COGNITIONS E D I C AT I O N S 2012

Cathy Wills and Prof. Dan Yakir

2013 2013 Daniel Zajfman and Martin Paisner at the dedication of the Maurice and Vivienne Wohl Institute for Drug Discovery

Lady Michels with Prof. Daniel Zajfman and Bob Drake

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8 DECADES OF DISCOVERY GALA DINNER

MAKING CONNECTIONS PROGRAMME LAUNCHED IN 2008, THE WEIZMANN UK MAKING CONNECTIONS PROGRAMME HAS FUNDED 32 R E S E A R C H C O L L A B O R AT I O N S . H E R E A R E T H E T I T L E S OF JUST A FEW… T H E I M PA C T OF EMOTION OF TIME PERCEPTION

F O U N D AT I O N S OF DARK ENERGY RESEARCH

OCEAN A C I D I F I C AT I O N

A POSSIBLE THERAPEUTIC TA R G E T F O R THE INFANTILE KRABBE DISEASE

THE I N T E R P L AY BETWEEN ALGORITHMS AND RANDOMNESS

“

TO ME THE WEIZMANN INSTITUTE EMBODIES TWO PRINCIPLES I HOLD DEAR. T H E F I R S T I S T H AT T H E PURSUIT OF SCIENTIFIC KNOWLEDGE IS A MARK OF A C I V I L I S E D S O C I E T Y. T H E S E C O N D I S T H AT ISRAEL, AS A JEWISH STATE, C O N T I N U E S T O S TA N D O U T A S A B E A C O N IN A TROUBLED WORLD

”

LORD MITCHELL VICE CHAIRMAN, WEIZMANN UK ONE OF THE FOUNDERS OF THE MAKING CONNECTIONS PROGRAMME

2008 MAKING CONNECTIONS SYMPOSIUM

Biological Complexity: from molecules to systems University College London

38

38

Prof. Eran Segal and Prof.Yitzhak Pilpel

Weizmann Institute participants with the founders of the Making Connections Programme: Lord Mitchell, Prof. Benny Chain and Sheridan Gould

3 83 8

7

WEIZMANN UK HAS FUNDED 5 MAKING CONNECTIONS SYMPOSIA IN THE UK IN LONDON AND MANCHESTER, AND A FURTHER 2 IN ISRAEL AT THE WEIZMANN INSTITUTE

15

OVER 15 LEADING UK UNIVERSITIES NOW H AV E C O L L A B O R AT I O N S I N I T I AT E D B Y T H I S M A K I N G CONNECTIONS PROGRAMME

77

77 RESEARCHERS FROM ISRAEL AND THE UK ARE WORKING TOGETHER A S A R E S U LT O F O U R MAKING CONNECTIONS PROGRAMME

£2m

JUST UNDER £2 MILLION POUNDS HAVE BEEN AWARDED TO UK AND WEIZMANN INSTITUTE SCIENTISTS

GET CONNECTED P R O M O T I N G C O L L A B O R AT I O N B E T W E E N THE UNIVERSITY OF MANCHESTER AND THE WEIZMANN INSTITUTE OF SCIENCE.

FUNDED BY LORD ALLIANCE CBE A N D E S TA B L I S H E D I N 2 0 1 1 , T H I S P R O G R A M M E HAS SUPPORTED 8 UNIQUE RESEARCH PROJECTS BETWEEN SCIENTISTS. T H E S E R A N G E F R O M L O O K I N G AT W H AT HELPS OUR IMMUNE CELLS CROSS FROM THE BLOODSTREAM TO THE TISSUE IN ORDER TO FIGHT INFECTION, TO U N D E R S TA N D I N G W H Y S O M E W O U N D S HEAL FASTER THAN OTHERS.

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8 DECADES OF DISCOVERY GALA DINNER

WEIZMANN UK SAFE CRACKING PHYSICS TOURNAMENT TEAMS OF YEAR 12 STUDENTS DESIGN, BUILD AND CRACK INTO EACH OTHER’S SAFES WHICH HAVE LOCKING MECHANISMS BASED ON THE PRINCIPLES OF PHYSICS. THE WINNERS OF THE UK TOURNAMENT ARE AWARDED A GRANT TO ENABLE THEM TO TRAVEL TO THE WEIZMANN INSTITUTE OF SCIENCE AND PA R T I C I PAT E I N T H E I N T E R N AT I O N A L T O U R N A M E N T.

1st

2014 TRINITY SCHOOL

WITH THANKS TO THE E C SOSNOW C H A R I TA B L E T R U S T F O R G E N E R O U S LY SUPPORTING THE 2014 UK COMPETITION WINNING TEAMS: 1ST – TRINITY SCHOOL, CROYDON 2 N D – D U LW I C H C O L L E G E 3 R D – YAV N E H C O L L E G E

2nd D U LW I C H C O L L E G E

2015 THE 2015 WEIZMANN UK PHYSICS SAFE CRACKING TOURNAMENT W I L L B E H E L D AT U C L A C A D E M Y IN FEBRUARY

F O R M O R E I N F O R M AT I O N A B O U T T H E SAFE CRACKING COMPETITION GO TO:

3rd

W W W. W E I Z M A N N . O R G . U K / S H A L H E V E T H FREIER-PHYSICS-TOURNAMENT

YAV N E H C O L L E G E 40

O R C O N TA C T LY D I A : 0 2 0 7 4 2 4 6 8 6 6 LY D I A @ W E I Z M A N N . O R G . U K

1975

B E S S I E L AW R E N C E STUDENTS 1996

E ach summer , eighty Y ear 1 3 students from around the world participate in the D r . B essie L awrence I nternational S ummer S cience I nstitute ( I S S I ) at the W eizmann I nstitute of S cience .

They spend four weeks working alongside Weizmann Institute scientists on real research projects, get the opportunity to explore Israel and make lifelong friends. They also have the chance to spend a week at a field school where they trek through the desert and investigate the unique ecosystem and wildlife of Israel.

WEIZMANN UK sends nine students each year to participate in the programme which has been running since 1969. Since its establishment over 370 UK students have participated in the programme.

2009 41

8 DECADES OF DISCOVERY GALA DINNER

THE WEIZMANN INSTITUTE OF SCIENCE IS ONE OF THE WORLD’S LEADING BASIC RESEARCH INSTITUTIONS. IT IS COMPRISED OF 250 E X P E R I M E N TA L A N D T H E O R E T I C A L R E S E A R C H G R O U P S A C R O S S F I V E FA C U LT I E S – M AT H E M AT I C S A N D C O M P U T E R S C I E N C E , P H Y S I C S , C H E M I S T R Y, B I O C H E M I S T R Y, A N D B I O L O G Y. 42

THE WEIZMANN INSTITUTE OF SCIENCE I N S I G H T S T H AT E M E R G E F R O M I T S L A B O R AT O R I E S H E L P P R O V I D E A F U N D A M E N TA L U N D E R S TA N D I N G O F T H E B I O L O G I C A L , C H E M I C A L , AND PHYSICAL WORLD, AND LEAD TO ADVANCES IN MEDICINE, T E C H N O L O G Y, A N D T H E E N V I R O N M E N T. T H I S I S S C I E N C E F O R T H E B E N E F I T O F H U M A N I T Y AT I T S B E S T. Weizmann Institute scientists are credited with inventing amniocentesis, blockbuster drugs for multiple sclerosis, nano materials and compounds for industrial and medical uses, advanced computer technology, and breakthrough data-storage options. Institute cancer research has led to many discoveries, including the protein implicated in certain lung cancers, the basis for the drug Erbitux to treat colorectal cancer and head and neck cancer, a new potential therapy for prostate cancer, the gene that encodes p53 – the tumor suppressor protein found to be dysfunctional in almost all cancers – and a protein that triggers chronic myelogenous leukemia.

The latter discovery provided the foundation for the development of Imatinib (known as Gleevec in the U.S. and Glivec in Europe). About 40 percent of Institute life science labs are involved in cancer research.

The Weizmann Institute is also an institution of higher education whose aim is to train the next generation of world-class scientists. Its academic arm, the Feinberg Graduate School, is the training ground of a quarter of Israel’s PhDs in science and maths. At any given time, the school is training 1,100 MSc and PhD students.

Every year, it confers about 130 MSc degrees, 130 PhD degrees, and 30 non-thesis MSc degrees to science and maths teachers through the unique Rothschild-Weizmann Program for Excellence in Science Teaching.

In addition, some 380 postdoctoral fellows work in Weizmann Institute labs, bringing novel ideas to the bench and creating future links to other labs abroad. Reflecting the international nature of science, the language of instruction is English.

The most important asset of the Weizmann Institute of Science is its people. It recruits some of the world’s leading scientists – Israel’s modern pioneers who are making major advances in the natural and exact sciences. Then it invests significantly in them, offering these investigators the best equipped laboratories and the opportunity to work shoulder-to-shoulder with other top scientists.

Weizmann Institute of Science researchers bring their innate curiosity and are propelled forward in their explorations by a multidisciplinary culture that is fostered by the Institute. As such, scientists from one field apply their skills in another and form collaborations across the artificial boundaries of faculties and departments. This fluid, cross-disciplinary culture has become a trademark of the Weizmann Institute.

43

8 DECADES OF DISCOVERY GALA DINNER

IF YOU ARE PLANNING A TRIP TO ISRAEL WE INVITE YOU TO INCLUDE A VISIT TO THE WEIZMANN INSTITUTE OF SCIENCE.

BE O U R G 44

SOME OF THE ACTIVITIES YOU WILL EXPERIENCE WHILE ON THE WEIZMANN INSTITUTE CAMPUS INCLUDE: • Visiting the state-of-the-art Barbara and Morris

Levinson Visitors Centre. The centre contains technologically advanced exhibits, taking the visitor on a journey of knowledge and discovery and opening up the world of science and that of scientists who uncover the secrets of nature and decipher the codes of the universe.

UEST

• Spending time at the Institute’s award-winning

Clore Garden of Science, a unique open-air museum which invites children and adults alike to explore the wonders of science and nature through 90 hands-on exhibits.

• Touring one of Israel’s historical landmarks,

the Weizmann House, once the home of Dr. Chaim Weizmann, first President of the State of Israel and founder of the Weizmann Institute of Science, and his wife, Dr. Vera Weizmann. The house was designed by the famous architect Erich Mendelsohn and was built on a beautifully landscaped hill overlooking the coastal plain to the west and the Judean Mountains to the east.

45

8 DECADES OF DISCOVERY GALA DINNER

RECENT

VISITS

Harry Woolf

2005

2006

Prof. Daniel Zajfman with Prof. Stephen Hawking

2007

Lord Turnberg visiting Weizmann House

2009

Rachel Berger Prof. Israel Bar-Joseph with Lord Winston

46

David Grunberg

2010

Daniel Dover and Lorna Fitzsimmons at Weizmann House

WEIZMANN UK Mission

Marcus Sieff Junior

Prof. Benny Chain, Julia Chain, Lady Young

“

ONE PICTURE IS WORTH A THOUSAND WORDS AND ONE TRIP TO THE INSTITUTE IS WORTH A THOUSAND PICTURES

Lady Sieff

2011

P R O F. H A I M H A R A R I

Lottie, Graham (Hull), Amanda, Daniel and Daniela Sieff

”

Daniel, Harry, Jessica, Tamsin and Amanda Gestetner Dr. Arabella Duffield

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8 DECADES OF DISCOVERY GALA DINNER

Spot David and Selina Marks!

2011

Ellen and Dan Shapiro and Myra Waiman

VISITS

RECENT VISITS

RECENT

Hayley and Jonathan Sieff with family and friends

Alex Fitzgibbons and Cristina Stenbeck

2012

de Botton Family visit to The Clore Garden of Science Miel, Talia and Zachary de Botton with Jacqueline and Marc Leland

48

Joanna Sara, Paul and Rebecca Phillips Helen and Peter Briess

2013

Karen Siem, Edna and Sasha Moross

2014

Alison, Ella and Avi Goldberg

Jonty Hurwitz

Michael and Carolyn Goldhill, Prof. Israel Bar-Joseph, inside Wolfson House

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8 DECADES OF DISCOVERY GALA DINNER

“

IF SUCCESSFUL, OUR STUDY M AY A L L O W U S T O M O V E F R O M E M P I R I C A L LY B A S E D T O P E R S O N A L LY B A S E D N U T R I T I O N , AND THUS TO PE RSO NA L LY TA I L O R E D M E D I C I N E

THE P E R SO N A NU TRITIO PR OJ E C T P R O F. E R A N S E G A L

”

W H Y D O S O M E P E O P L E R E S P O N D T O T H E S A M E F O O D S D I F F E R E N T LY ?

50

Why do some people gain weight while others keep slim and trim? High blood sugar levels, which lead to a rise in insulin levels, are associated with many diseases, such as obesity, diabetes and heart disease. But there is a tremendous variability among individuals in how they react to different food – and in who develops disease and who doesn’t.

With that and the other data, they developed algorithms that can predict the response of each individual’s microbiota to a wide variety of foods. Subjects received access to a website with these predictions, a profile of their own gut microbes with an analysis of how these affect the blood sugar – and, a nice plus, a diet tailored personally for them.

Prof. Eran Segal and Dr. Eran Elinav believe that the answer lies in the human gut. The differences across individuals may be explained, they say, by variations in the composition and function of a vast array of microbes – the gut microbiota.

“This diverse and poorly understood ecosystem is among the densest population of microbes on earth and has been recently highlighted to have fundamental roles in many facets of human physiology,” says Dr. Elinav.

“If successful, our study may allow us to move from empirically based to personally based nutrition, and thus to personally tailored medicine,” says Prof. Segal.

With this hypothesis in hand, the duo launched an experiment to garner insights about how foods affect the microbiota of different individuals. In the experiment – a local pilot project in Israel with the intention to expand overseas – they equipped human volunteers with devices that monitored the rise and fall of their blood sugar throughout the day, over a 7-day period.

Prof. Segal, a mathematician and computational biologist develops computational models aimed at understanding how molecular components interact to carry out complex biological functions. Dr. Elinav, who is a researcher and a medical doctor, has made major strides in understanding how the microbiota interacts with the mammalian hosts, and how these interactions effect disease susceptibility. Prof. Eran Segal has a joint appointment in the Department of Mathematics and Computer Science and the Department of Molecular Cell Biology; and Dr. Elinav is a member of the Department of Immunology.

Dr. Eran Elinav and Prof. Eran Segal work on developing quantitative models for all levels of gene regulation, including transcription, chromatin, and translation.

LIS ED N

Dr. Eran Elinav and Prof. Eran Segal

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8 DECADES OF DISCOVERY GALA DINNER

AMANDA & DANIELA SIEFF ARE DELIGHTED, ONCE AGAIN, TO SUPPORT TONIGHT’S E V E N T. I T I S A P R I V I L E G E T O H O N O U R T H E C R E AT I V I T Y A N D ACHIEVEMENTS OF WEIZMANN SCIENTISTS, AS WELL AS THE L I F E O F T H E I R G R A N D F AT H E R , I S R A E L S I E F F, T H E I N S T I T U T E ’ S F O U N D E R ; T H E I R G R E AT U N C L E , D A N I E L S I E F F, I N W H O S E MEMORY THE INSTITUTE WAS C R E AT E D , E I G H T Y Y E A R S A G O ; A N D T H E I R F AT H E R M A R C U S S I E F F, O N E O F I T S M O S T PA S S I O N AT E C H A M P I O N S .

I have been a passionate supporter of the Weizmann Institute for many years. It’s an enthusiasm that I inherited from my father, Gilbert, who was among the earliest of the Institute’s benefactors. I want to say a special thank you to Weizmann for giving me such warm support with my musical career. My debut performance was at the Wonders of Weizmann gala in London two years ago.

Then, at a dinner in Tel Aviv in the same year, to celebrate the de Botton Institute for Protein Profiling, I was able to sing some of the French chansons that my father used to sing to me as a child. I am honoured that the Institute now bears his name and I am touched and gratified by Weizmann’s encouragement to follow my dream and reach such an exciting moment in my life.

Miel’s first album, ‘Magnetic’, will be released later this year. It is a mixture of her favourite French chansons, but with twists such as a reggae version of Edith Piaf’s classic ‘Je ne regrette rien’, and new songs that she has written with the collaboration of her producer, Andy Wright.

The first of these to be released is ‘Bad Men’.

The single will be out in July this year, accompanied by an epic music video. Look out for it on YouTube, iTunes, Amazon and Spotify and keep up to date with all Miel’s exciting news on www.mielmusic.co.uk and www.facebook.com/mielmusicuk

8 DECADES OF DISCOVERY GALA DINNER

HILDA LEWIS, ROBERT LEWIS & C AT H Y W I L L S ARE DELIGHTED TO BE A S S O C I AT E D W I T H T H E WEIZMANN INSTITUTE OF SCIENCE AND ARE VERY HAPPY TO SUPPORT THIS SPECIAL WEIZMANN UK ‘8 DECADES OF DISCOVERY’ GALA EVENT

8 DECADES OF DISCOVERY GALA DINNER

THE DWEK FA M I LY WISH THE EVENING EVERY SUCCESS, REMEMBERING MAURICE DWEK, AND HIS WORK WITH THE WEIZMANN INSTITUTE

JANET DE BOTTON LAURA & BARRY TOWNSLEY ELIZABETH & D A N I E L P E LT Z

8 DECADES OF DISCOVERY GALA DINNER

SUPPORTING PROJECTS WHICH NOURISH SCIENTIFIC MINDS IS THE MOST I M P O R TA N T I N V E S T M E N T W E CAN MAKE FOR THE FUTURE OF SCIENTIFIC DISCOVERY

DR. ARABELLA DUFFIELD

8 DECADES OF DISCOVERY GALA DINNER

SIR HARRY & L A D Y D J A N O G LY TA K E G R E AT P R I D E I N T H E I R A S S O C I AT I O N W I T H T H E WEIZMANN INSTITUTE OF SCIENCE AND WISH THIS 8 DECADES OF DISCOVERY GALA EVENT EVERY SUCCESS

WISHING YOU CONTINUED SUCCESS

LORD ALLIANCE

ELLEN & DAN SHAPIRO ARE PROUD TO SUPPORT THE WEIZMANN INSTITUTE AND ITS EXTRAORDINARY EFFORTS IN GROUND BREAKING RESEARCH

I AM PROUD TO BE A S S O C I AT E D W I T H T H E WEIZMANN INSTITUTE OF SCIENCE AND TO SUPPORT ITS WONDERFUL SCIENTIFIC RESEARCH

DENIS RAEBURN

WAY N E & G I L L I A N GILLIAN PHILLIPS WISH THE WEIZMANN INSTITUTE CONTINUED SUCCESS IN ALL ITS ENDEAVOURS

THE CHAIN FA M I LY WISH YOU EVERY SUCCESS

I AM DELIGHTED TO SUPPORT THE 8 DECADES OF DISCOVERY GALA DINNER

LADY MICHELS

ROCHELLE & MAXWELL NISNER W O U L D L I K E T O C O N G R AT U L AT E WEIZMANN ON ITS PROGRESS AND HOPE EVERYONE ENJOYS THE 8 DECADES OF DISCOVERY GALA DINNER

THE JOSEPH FA M I LY WISH THE EVENING EVERY SUCCESS

SHERIDAN & GERRY LEWIS ARE PROUD TO BE ASSOCIATED WITH THE WEIZMANN INSTITUTE OF SCIENCE. WE WISH THE INSTITUTE CONTINUED SUCCESS IN ADVANCING SCIENTIFIC KNOWLEDGE FOR THE BENEFIT OF HUMANITY

WEST END TRAVEL ARE DELIGHTED TO BE ASSOCIATED W I T H WEIZMANN UK AND WISH THEM EVERY SUCCESS. For Israel and Worldwide Travel call 0208 958 3188 or email info@westendtravel.co.uk

THE SANDLER FA M I LY WISH THE EVENING EVERY SUCCESS

KEREN M I TZVAH TRUST C O N T I N U E Y O U R G R E AT W O R K

8 DECADES OF DISCOVERY GALA DINNER

WORLDWIDE FRIENDS PARTNERS IN GLOBAL PHILANTHROPY THE WEIZMANN INSTITUTE OF SCIENCE RELIES ON A NETWORK OF FRIENDS AND SUPPORTERS AROUND THE GLOBE. AUSTRALIA

EUROPE

GERMANY

ISRAEL

Mr Stephen Chipkin

Mr Robert Drake

Dr Manfred Gentz

Mr Shimshon Harel

Chair of the European Committee for the Weizmann Institute of Science

Chair

Chair

HUNGARY

Ms Yael Goren-Wegman

Mr Zohar Menshes

Dr István Réczicza

Chair

Ms Rina Michael Executive Director

BRAZIL Mr Mario Fleck Chair

Executive Vice-President

Chair

UNITED KINGDOM

Dr Robert Parienti

NETHERLANDS

Mr Martin Paisner CBE

Delegate General

MEXICO

FRANCE-EUROPE

Mr Martin Kushner

Prof. Francois Gros

President

Mr Dany Schmit Executive Director

CANADA Ms Catherine Beck Chair

Mrs Susan Stern National Executive Director

Executive Director

Dr Ruud Vlaming Co-Chair

Mr Yossi Herman

Chair

Co-Chair

SWISS-ROMANDE

S PA I N

Mr Jean-Marc Brunschig

Mr Rubin Lerner

Chair

Chair

I TA LY

SWITZERLAND

Mr and Mrs Joseph Nissim

Mr Eric Stupp

Presidents

Mr Eric Labi Chair

Chair

Chair

Ms Sheridan Gould Executive Director

U N I T E D S TAT E S OF AMERICA Ms Ellen Merlo National Chair

Dr Jay A Levy President

Mr Marshall S Levin Executive Vice President & CEO

S A V E T H E D AT E I N T E R N AT I O N A L B O A R D 2 014 9 -1 2 N O V E M B E R P L E A S E J O I N U S AT T H E W E I Z M A N N I N S T I T U T E O F S C I E N C E F O R T H E 6 6 T H I N T E R N AT I O N A L B O A R D M E E T I N G . T H I S Y E A R ’ S T H E M E W I L L F O C U S O N T H E I N S T I T U T E ’ S I N T E G R AT E D C A N C E R C E N T R E WHICH IS HARNESSING BASIC SCIENCE TO FIGHT CANCER. A M A J O R G A L A E V E N T T O C E L E B R AT E T H E W O L F S O N F O U N D AT I O N ’ S EXTRAORDINARY SUPPORT OF THE WEIZMANN INSTITUTE SINCE ITS INCEPTION IN 1949, AS WELL AS THE TRADITIONAL HONORARY P H D C E R E M O N Y W H I C H W I L L I N C L U D E P R O F. S I M O N S C H A M A A N D MIEL DE BOTTON FROM THE UK.

F O R F U R T H E R I N F O R M AT I O N P L E A S E V I S I T O U R W E B S I T E : W W W. W E I Z M A N N . O R G . U K O R C O N TA C T B E N M O R R I S O N T. 0 2 0 7 4 2 4 6 8 6 3 E . B E N @ W E I Z M A N N . O R G . U K

8 DE CAD ES OF DISOVERY G AL A DINNER 20 14

Registered charity no. 232666

WEI ZM A N N U K

WEIZMANN UK 9 HAMPSTEAD GATE 1A FROGNAL LONDON NW3 6AL +44 (0)20 7424 6864 POST @WEIZMANN.ORG.UK WWW.WEIZMANN.ORG.UK

8 DECADES OF DISCOVERY G A L A D I N N E R | T H U R S D AY 2 6 J U N E 2 0 1 4 SCIENCE MUSEUM