2011 KIEC - KY EPSCoR Joint Conference Program Book

ENERGY

May 26, 2011, Galt House, Louisville, Kentucky

AGRICULTURE

A Joint Event: 7TH KY INNOVATION & ENTREPRENEURSHIP (KIEC) & BIOMEDICAL RESEARCH

COMMERCIALIZATION

SPACE RESEARCH

16TH KY EPSCOR STATEWIDE CONFERENCE

Kentucky Council on Postsecondary Education Steven L. Beshear Governor

Robert L. King President

1024 Capital Center Drive, Suite 320 Frankfort, Kentucky 40601 Phone: 502-573-1555 Fax: 502-573-1535 http://www.cpe.ky.gov

To All Conference Attendees: Welcome all to the 2011 Kentucky Innovation and Entrepreneurship & EPSCoR Conference. It is encouraging to see so many Kentucky researchers interested in taking their discoveries to the next step, enhancing Kentucky’s economy. In March of this year, the Kauffman Index of Entrepreneurial Activity reported Kentucky’s rate of increase in entrepreneurial activity over the past decade to be the seventh highest among all states, with annual growth in 2009-10 alone of four percent. New studies are more encouraging—reporting that all net-job creation since 1977 is attributable to start-up companies. That is a good news message for our state and nation.

At the Council on Postsecondary Education we celebrate this linkage and are constantly looking for opportunities to strengthen our universities and their capacities to educate the next generation innovators, while supporting our current faculty and researchers. Taking what we learn from our laboratories to those with entrepreneurial talents, and from there to the people of the world is central to Kentucky’s P-20 mission.

Congratulations to all who make this conference a success and to those of you who are participating every day in making these concepts come to life.

Sincerely,

Robert L. King President

KentuckyUnbridledSpirit.com

An Equal Opportunity Employer M/F/D

Commonwealth of Kentucky

Office of the Governor Steven L. Beshear

700 Capitol Avenue Suite 100 Frankfort, KY 40601 (502) 564-2611 Fax: (502) 564-2517

Governor

Greetings: On behalf of the Commonwealth of Kentucky, I would like to welcome you to the Joint Seventh Kentucky Innovation and Entrepreneurship Conference (KIEC) and Sixteenth EPSCoR Conference.

Innovation and entrepreneurship are at the center of knowledge-based economic development. To stay competitive, new ideas need to be pursued through rigorous research and development resulting in a continuous pipeline of technologies for the creation of new businesses. This requires research infrastructure and a skilled technical and business development workforce. I am pleased to note that this joint conference represents your work in building our science and engineering capacity and research excellence through several state-funded initiatives including Kentucky EPSCoR, Kentucky Science and Engineering Foundation, Kentucky Commercialization Fund and the Kentucky SBIR-STTR Matching Funds Program. Small-tech businesses developed through these efforts create high-paying jobs that help retain students graduating from Kentucky universities.

The Kentucky Science and Technology Corporation (KSTC) has established itself as a leader in not only developing new programs but also effectively implementing these to enhance the capacity of people, organizations and businesses in Kentucky enabling them to effectively compete nationally and internationally.

This annual conference organized by KSTC offers a platform to share your ideas and experiences with others and a network for future collaborative opportunities. I know your participation in the conference will make it very successful and you will return home more enthused and richer in ideas.

Best wishes for a successful conference.

Sincerely,

Steven L. Beshear

www.Kentucky.gov

An Equal Opportunity Employer M/F/D

TABLE OF CONTENTS

Governor Beshear Welcome Letter…………………………………………………………………………………….....…… i KY CPE President Robert King Welcome Letter………………………………………………………………………….…

ii

KSTC/KSEF Welcome and Overview…………………………………………….…………………………………………….. iii Table of Contents………………………………...……………………………………………………………………………….…

1

KSTC Funding Programs and Their Socio‐Economic Impact………………………………...…………………………

3

Conference General Schedule…………….……………………………………………………………………………………… 7 KY EPSCoR Subcommittee Agenda ……………………………………………………………………………………………

9

Company Display Tables ………………………………………………………………………………………………………….. 13 Session Summaries………………………………………………………………………………………………………………….

15

Speaker and Moderator Bios….………………………………………………………………………………………………….

23

Poster Presenters………..…………………….…………………………………………………………………………………….

35

Poster Abstracts ……………………………..………………………………………………………………………………………

39

Conference Attendees …………………………………………..……………………………………………………………….

89

Menu………………….…………………………………………………………………………………………………………………. 105 NOTES…………………………………………………………………………………………………………………………………..

106

Floor Plans……………………………………………………………………………………………………………………………..

111

1

2

Technology Based Economic Development

KENTUCKY SCIENCE AND TECHNOLOGY CORPORATION

K S E F F u n d i n g P r o g r a m s a n d T h e i r S o c i o ‐ E c o n o m i c I m p a c t IMPACT:

PROGRAMS:

Follow On Funding: $11 in Federal and In‐ dustrial Funds for Each $1 KSEF Invested

Kentucky Science and Engineering Foundation (KSEF) builds science and engineering capacity by proactively investing in advanced and application oriented R&D, to strengthen innovative ideas and shape them in to emerging technologies for commercialization.

Young Investigator Awards: 11 KSEF Awardees Received NSF CAREER; 1 DoD Young Investigator Award Technological Innovations (KSEF & KCF): • • • •

108 Invention Disclosures 97 Patent Applications 58 Provisional Patents 40 Issued Patents

Kentucky Commercialization Fund (KCF) enables university faculty in commercializing the tech‐ nologies developed through R&D. Kentucky Phase Zero and Phase Double Zero (Ph Z and Ph DZ) SBIR‐STTR Proposal Assistance Program is designed to aid for‐profit Kentucky based companies to write competitive proposal to receive funds from the SBIR or STTR funds from participating federal agencies.

Kentucky SBIR‐STTR Matching Fund (KY SBIR/STTR Matching) program is designed to invest in for‐profit KY based companies that have been granted SBIR or STTR from any federal agency.

Technology Development & Commerciali‐ zation: 8 KSEF funded developments also received KCF funding for commercialization

KSEF

KCF

Ph Z / Ph DZ

KY SBIR Matching

Economic Development:

Number of Awards

274

48

170

109

$15,484,889

$5,848,405

$571,520

$25,978,160

$ 170,457,864

Not Applicable

$11,288,172

$44,291,436

11 : 1

New Business Creation

20 : 1

3.5 : 2

• 12 KSEF & 12 KCF Awardees formed New Businesses SBIR/STTR Assistance Grants: • ROI: 20:1

Program Data Since Inception

Funds Awarded Federal Leverage Funds Return on Investment

Source Follow on Funding from R&D Investments Federal, $154,578,417, 91% Industrial, $7,430,636, 4%

Private, $8,448,811, 5%

Sources of Federal SBIR‐STTR G r a n t s t o K e n t u c k y C o m p a n i e s

Science & Technology Research & Infrastructure Building

KY EPSCoR Programs and Their Socio-Economic Impact 10 Year IMPACT: (2000 - 2010)

PROGRAM MISSION:

Direct Funding: $260 million

KY EPSCoR is an infrastructure building program for research at KY’s colleges & universities. Our mission is to help the Commonwealth’s academic institutions competitively win Federal R&D awards in Science, Technology, Engineering, & Math.

•

82% are from Federal Funds

•

$9 of Federal for each state $1 invested EPSCoR Funding to Kentucky

STATEWIDE PROGRAM ORGANIZATION:

Impacts: Knowledge Base, People, Jobs •

Manuscripts Published: 3,420

•

People directly impacted by Funding: 4,592

•

Jobs Created: 1,093

How Does KY Compare to Other EPSCoR States?

Percentage of the total annual federal funding for all academic R&D

Percentage of Federal Funding

0.85% 0.75% 0.65%

0.81% 0.76%

Kentucky % All EPSCoR State Average (excludes KY)

0.77%

0.69%

0.60% 0.56%

0.55%

0.56% 0.46%

0.45% 0.35%

0.35%

0.25% '85 '86 '87 '88 '89 '90 '91 '92 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08

Year

9:15 A 10:00A

Session 1. Innovation Leading to Technology Transfer Speaker: Stephen Fleming, Georgia Institute Of Technology Moderator: Kris Kimel, Kentucky Science and Technology Corporation

10:00 A 10:45 A

8:45 A 9:15 A

Registration, Poster Set-up and Breakfast (8:00 - 8:45 AM) Welcome Remarks Welcome: Maria Labreveux, Mahendra Jain, and Rick Kurzynske, KSEF/KSTC Welcome Remarks: Robert King, Council on Postsecondary Education Ballroom C

2nd Floor

Plenary Sessions

CONFERENCE SCHEDULE

Session 2. Assessing Changes in Kentucky’s Economy and Innovation Capacity Speaker: Trent Williams, Regional Technology Strategies Moderator: Kris Kimel, Kentucky Science and Technology Corporation

11:30 AM - 12:15 PM

Jones French Segell

1:15 - 2:00 PM

Jones French

2:45 - 3:30 PM

Jones French Stopher McCrea

Women in Science / FDA Approval / Grantsmanship / e-Portfolios

2nd Floor, Exhibit Hall

Parallel Sessions :

Session 3C. International Space Station as a Platform for Innovation, Economic Development, and STEM Education Speaker: Marybeth Edeen, ISS National Lab Office, NASA Moderator: Kris Kimel, Kentucky Science and Technology Corporation

12:15 to 1:15 PM – LUNCH Session 4A. Access to Federal Labs Speaker: Rick Shindell, Federal Labs Consortium for Technology Transfer / Zyn Systems Moderator: Mahendra Jain, Kentucky Science and Technology Corporation

Segell

Fed Labs/ Innovating Local Economies / S&T Strategies

Parallel Sessions:

3rd Floor

2nd Floor, Ballroom C

3rd Floor

Session 3A. USDA-NIFA: Future Investments for Agricultural Research, Education, and Extension Challenges Speaker: Diana Jerkins, USDA National Institute of Food and Agriculture Moderator: Nancy Cox, University of Kentucky Session 3B. DOE: “Powering” Outside the Box Speaker: Sirini Mirmira, ARPA-E Moderator: Len Peters, Kentucky Energy and Environment Cabinet

Session 3D. Graduating Soon? Exploring Your Career Choices Panel: Gregory M. Jones, Booz | Allen | Hamilton, and Don Fitzpatrick, IBM Moderator: Aman Singh Das, Vault Inc

Stopher

Federal Funding Opportunities - Career Counseling

Parallel Sessions:

3rd Floor

10:45 to 11:30 AM – Poster Session ODD numbers / Table Top Presentations / Coffee Break (Exhibit Hall)

Session 4B. Imagination Powering Local Economies: The Role of University Research and Technology Development in Fostering Growth Speaker: Justin Anderson, Wisconsin Alumni Research Foundation Moderator: Mehdi Yazdanpanah, NaugaNeedles Session 4C: Conversations on Kentucky’s Science and Technology Strategy Group Discussions led by Trent Williams, Regional Technology Strategies Moderator : Rick Kurzynske, Kentucky Science and Technology Corporation 2:00 to 2:45 PM – Poster Session EVEN numbers / Table Top Presentations / Coffee Break Session 5A. Women, Science and Entrepreneurship Speakers: Lisa Sobolewski, DHS; Jenny Servo, Dawnbreaker, Jen White, University of Kentucky Moderator: Marybeth Edeen, ISS National Lab Office, NASA Session 5B. Triangulation for Success: Navigating the FDA Approval, Academic Research, and NIH Granting Processes Speaker: Dan Wermeling, University of Kentucky Moderator: Ruth Voor, Vivorte Session 5C. Competitive Grantsmanship in a Tight Federal Budget: Strategies for Success Speaker: Anna Palmisano, Department of Energy and USDA (Retired) Moderator: Nancy Martin, University of Louisville Session 5D. “Lost in Translation” Optimizing your resume and e-portfolio Live Webinar Speaker: Jason Levin, Vault Inc Moderator: Aman Singh Das, Vault Inc

7

2:45 - 5:00 PM

Segell Coe

3:30 P 4:15 P 4:15 P 5:00 P

Jones

2nd Floor, Exhibit Hall

KY DOE EPSCoR Program: NEW and Existing Research Opportunities Chair: Eric Grulke, University of Kentucky KY NIH-IDeA Sub-committee Inaugural Session Director: Nigel Cooper, University of Louisville

Taylor

Beckhm

NASA KY Space Grant and EPSCoR Programs: Research and Activities Director: Suzanne Smith, University of Kentucky Associate Director: Janet Lumpp, University of Kentucky

French

KY EPSCoR / IDeA Sub-committee Meetings Intellectual Business Property

3rd Floor

KY NSF EPSCoR Program: Ongoing Research Directors: John Connolly (former) University of Kentucky and Rodney Andrews (current), University of Kentucky

Session 6. Business Planning and Market Research Speaker: Jenny Servo, Dawnbreaker Moderator: Vickie Yates Brown, Nucleus Session 7. Protecting Your Technology During the Commercialization Process Speaker: Stephen C. Hall, Esq., Stoll Keenon Ogden PLLC. Moderator: Blaine Ferrell, Professor, WKU

4:30 PM to 5:00 PM – Poster Removal

8

Breakout Session: KY NIH‐IDeA Sub‐committee Session Location: 3rd Floor, Galt House East, Taylor Room Time: 2:30 – 5:00pm

2:30 – 2:45 Load Presentations on laptop

Agenda:

2:45 – 2:55 Introductions and

“Why Organize an IDeA Subcommittee?” – Liz Knapp, KY EPSCoR Statewide Office

2:55 – 4:20 Center Presentations: (10 min each, 2 min for questions)

2:55 – 3:07 KY INBRE Network Nigel Cooper – UofL 3:07 – 3:19 COBRE – Oral Health Jeffrey Ebersole, UK 3:19 – 3:31 COBRE – Birth Defects Robert Greene, UofL 3:31 – 3:43 COBRE – Obesity & Heart Disease Lisa Cassis, UK 3:43 – 3:55 COBRE – Diabetes & Obesity Aruni Bhatnagar, UofL 3:55 – 4:07 COBRE –Cancer Targets John Eaton, UofL 4:07 – 4:19 COBRE – Spinal Cord Injury Scott Whittemore, UofL

4:20 – 4:27 Break

4:27 – 4:57 Open Discussion

Topics Discussion Leader a) Undergraduate Pipeline, Summer Mentors Pam Feldhoff, UofL (10 min) b) Bioinformatics needs Eric Rouchka, UofL (10 min) c) Core Facilities‐ collaborations Nigel Cooper, UofL (10 min)

4:57 – 5:00 Wrap‐up, What’s next .....

Acronym Key INBRE – IDeA Networks of Biomedical Research Excellence COBRE – Center of Biomedical Research Excellence

9

Breakout Session: KY DOE EPSCoR Sub‐committee Session Location: 3rd Floor, Galt House East, Beckham Room Time: 2:30 – 5:00pm

NEW & Existing Research Opportunities in DOE EPSCoR Chair: Eric Grulke, UK

Agenda:

1. NEW DOE EPSCoR Implementation Award Opportunity • Funding objectives and • requirements

2. Current Implementation Award • Final Report needs

3. Renewal Award (3 year) [CLOSED SESSION] • re‐budgeting.

10

Agenda: KY NSF EPSCoR Statewide Conference Breakout Session (2:45 – 5:00pm) Thursday, May 26, 2011 Segell Room

Galt House East, Suite Tower, 140 North Fourth Street Louisville, KY 40202 http://www.kyepscor.org/Conferences/2011_May26_KEIC_Louisville/main.htm

2:45p – Introduction, overview and background.

John Connolly and Rodney Andrews 2:55p – Presentation of Kentucky State University EPSCoR Cyberinfrastructure Program Chi Shen EPSCoR RII “Track 1” Initiative Presentations – Update AAAS slides and add: (1) responses to AAAS recommendations; (2) future goals, metrics, timeline; (3) EPSCoR budget overview (carryforward and next year’s commitments).

3:00p – 3:20p – CAM 15 minutes for presentation and 5 minutes for questions.

Gang Cao and colleagues 3:20p – 3:40p – KY NanoNET 15 minutes for presentation and 5 minutes for questions.

Kevin Walsh and colleagues 3:40p – 4:00p – Bioengineering 15 minutes for presentation and 5 minutes for questions.

Andi Gobin, Hainsworth Shin and colleagues 4:00p – 4:20p – Ecological Genomics 15 minutes for presentation and 5 minutes for questions.

Chris Schardl and colleagues 4:20p – 4:35p – “Track II” EPSCoR VOEIS 10 minutes for presentation and 5 minutes for questions.

David White and Barbara Kucera 4:35p – 5:00p – General Discussion, Project Integration Committee, Adjourn

11

12

BUSINESS DISPLAYS

Client Company Advanced Energy Materials, LLC

Company Brief Contact Information Advanced Energy Materials, LLC At the Conference: (AdEM) is a new company established in

2009 to develop commercial reactors Vasanthi Sunkara, President (NanoWireX and PlasmaX) and and CEO materials used in Li ion batteries, (vasanthi.sukara@gmail.com) capacitors, and low cost solar cells. The

company was started with funds from 201 East Jefferson Street, Suite

its promoter to set up an office and lab 303, Louisville, KY 40202

in the business incubator Metacyte in Ph: 502‐457‐4178

downtown Louisville.

Fax:502‐254‐5055 http://advancedenergymat.co adenergymat@gmail.com m/home.html

At the Conference: NuForm uses a patented beneficiation

process to obtain high purity, value‐ NuForm Materials, LLC. Anne Oberlink, Scientist added ceramic materials for automotive (anne.oberlink@nuformmateria and aerospace composite material ls.com) applications that require superior performance, improved fuel efficiency, Ph: (502) 857‐0700 and low cost. Our customers use our P.O. Box 220 Sadieville, KY recycled ash derived ceramics to

produce improved and lightweight 40370

metal matrix and polymer composites

that, in turn, enhance the performance

of their customers' products in the field. http://www.nuformmaterials.c As an added benefit, our products are om/contact.html recycled directly from an energy byproduct making them environmentally friendly, sustainable, and inexpensive.

Advanced Dynamics is a high‐tech firm Advanced Dynamics, Inc At the Conference: specializing in multi‐disciplinary, multi‐

physics, multi‐scale and multi‐fidelity Liping Xue, Principal Scientist

(4M) modeling and simulation, including (xuelp2005@gmail.com)

aeroelasticity (AE),

aeroservoelasticity(ASE),

aeroservothermoelasticity and 1500 Bull Lea Road, Suite 203, http://www.advanceddynamics propulsion (ASTE‐P), as well as fluid Lexington, KY 40511 ‐usa.com/ dynamics, structural mechanics, system Ph: (859) 699‐0441 dynamics and control, multiphase flows

and combustions, etc.

Fax:(859) 243‐5615 Contact@advanceddynamics‐ usa.com

13

14

SESSION SUMMARIES

This session will outline an economic context for crafting an updated Science and Technology strategy for the state of Kentucky. It will include a thumbnail sketch of the economy in which the Commonwealth’s original 1999 strategy was embedded and an analysis of significant developments within Kentucky’s economy over the ensuing decade. The session will conclude with an assessment of three key elements that will shape the new strategy: innovation capacity, entre‐ preneurial energy, and access to capital. ___________________________________________

Session 3A: USDA‐ NIFA: Future Investments for Agricultural Research, Education, and Extension Challenges

Speaker: Diana Jerkins, USDA National Institute for Food and Agriculture, Washington, DC Moderator: Nancy Cox, University of Kentucky

The use of agricultural lands is changing in both the intensity and the diversity of products being provided for human consumption. The grand challenge for agriculture is how to reconcile agricultural productivity with environmental and social integrity. Agricultural and forest lands and environs can be managed to respond to increasing demand for resources and services which it can provide while valuing the health of the environment. Agricultural lands, encompassing over 940 million acres of working ranch and farm lands or approximately half the U.S. landmass, have had major impacts on the function, production, and economics of agricultural services.

The National Institute of Food and Agriculture (NIFA) funds about 2000 competitive research grants yearly and approximately the same number of formula‐funded (direct payment to institutions of higher education) research projects. The Agriculture and Food Research Initiative (AFRI) at NIFA is charged with promoting and funding research, education, and extension efforts that address all components of agriculture sustainability, including farm efficiency and

Session 1: Innovation and Entrepreneurship Leading to Technology Transfer

Speaker: Stephen C. Fleming, Georgia Institute of Technology Moderator: Kris Kimel, Kentucky Science and Technology Corporation

Universities are central to any model that is developed to accelerate knowledge‐based economic development. They provide a pipeline of ideas, technological innovations and, in many cases, serve as a hub for new start‐ups. Further, universities play a critical role in attracting and retaining businesses. Universities with a strong research focus and passionate researchers serve as magnets to attract young minds who continue to innovate, providing a pipeline of valuable technologies that become candidates for technology transfer. State initiatives to seed research at early stages greatly help in developing home‐grown ideas, ultimately yielding large Federal R&D funds. Hiring key personnel and creating a supportive entrepreneurial culture are key to commercialization and the creation of new start ups. Universities with a research and entrepreneurial environment that support the advancement of faculty and its graduates, partner with businesses, and capture innovations to enhance technology transfers, contribute to local economic growth. Stephen Fleming will be presenting the common threads that connect successful models of economic development acceleration. He will also provide examples of successful strategies implemented at Georgia Tech’s Institute of Technology. ___________________________________________

Session 2: Assessing Changes in Kentucky’s Economy and Innovation Capacity

Speaker: Trent Williams, Regional Technology Strategies Moderator: Kris Kimel, Kentucky Science and Technology Corporation

15

SESSION SUMMARIES

Session 3C: International Space Station as a Platform for Innovation, Economic Development, and STEM Education

Speaker: Marybeth Edeen, ISS National Lab Office, National Aeronautics and Space Administration (NASA) Moderator: Kris Kimel, Kentucky Science and Technology Corporation

This presentation will discuss what it means for the International Space Station (ISS) to have been designated as the nation’s newest National Lab and how that designation is being used to broaden the approach to and scope of research done on the ISS to benefit the American people. The designation as a National Lab has allowed the approach to research to open up to include a more commercial model which some entrepreneurial companies are taking advantage of. Additionally, the scope of research has broadened beyond NASA’s research areas to include research of interest to other government agencies and the private sector.

Capitalizing on these changes can open up space flight research so anyone can participate, including students of all ages. ___________________________________________

Session 3D: Graduating Soon? Exploring Your Career Choices

Panel: Gregory M. Jones, Booz Allen Hamilton and Don Fitzpatrick, Global Cisco Alliance‐IBM Corporation Moderator: Aman Singh Das, Vault Inc

Why is there an urgent need for Science, Technology, Engineering and Math (STEM) graduates in developing new processes, new technologies, new systems, and how can you leverage these opportunities into lucrative and successful careers? Join Aman Singh Das from Vault, Inc on an interactive panel discussion with Booz Allen Hamilton and Cisco Alliance representatives Dr. Gregory Jones and Don Fitzpatrick.

profitability, ranching, renewable energy, forestry (both urban and agroforestry), aquaculture, rural communities and entrepreneurship, human nutrition, food safety, biotechnology, and conventional breeding. In addressing the needs to increase available food, fiber, and fuel production for a growing domestic and international population, NIFA has identified Challenge Areas through the AFRI program: Childhood Obesity Prevention, Climate Change, Global Food Security, Food Safety, and Sustainable Bioenergy. These Challenge Areas are complemented by additional programs to support student education through the Fellows program and the Foundation program for basic research activities. Additional Competitive Funding such as the Small Business Innovation Research (SBIR), Beginning Farmers and Ranchers Development, Specialty Crops, 406 Integrated, and Higher Education programs provide additional support for efforts related to specific priority topics.

This presentation will demonstrate the types of programs available for funding research, education, and extension efforts to a broad range of eligible recipients. ___________________________________________

Session 3B: DOE: “Powering” Outside the Box

Speaker: Srini Mirmira, Advanced Research Projects Agency‐ Energy (ARPA‐E) Moderator: Len Peters, Kentucky Energy and Environment Cabinet

The need to increase the use of renewable and alternative energy sources has become paramount, challenging scientists and innovators to not settle for incremental improvements but to rapidly accelerate discoveries and translate them into marketable technological innovations.

Dr. Mirmira’s presentation will be on the vision leading to the creation of ARPA‐E “to bridge gaps in the energy innovation pipeline”, its priorities and opportunities. ___________________________________________ 16

SESSION SUMMARIES

Obama during his State of the Union Address on January 25, 2011, highlight the importance of innovation and its impact on the economy.

Investments in education, research, and science are important – not only for the knowledge generated, but also for the potential to create new jobs and industries while improving our overall quality of life.

Where will the next big idea originate, and who will take that idea and turn it into a product or a business? The answer could be right here and the person could be you. This session will provide the framework protecting your ideas, identifying resources, and engaging your inner entrepreneur. ___________________________________________

Session 4C: Conversations on Kentucky’s Science and Technology Strategy

Speaker: Trent Williams, Regional Technology Strategies Moderator: Rick Kurzynske, Kentucky Science and Technology Corporation ‐ KY ESPCoR

This breakout session’s conversation will address two important dimensions for the new science and technology strategy. First, what are the key strategic elements that this plan should target? The actions that defined the 1999 strategy addressed Enterprise Development, Manufacturing Modern‐ ization, Technological Infrastructure, and People.

Second, what specific technology and R&D domains hold the most promise for Kentucky’s economic future? ___________________________________________

Session 5A: Women, Science, and Entrepreneurship

Speaker Panel: Lisa Sobolewski, DHS; Jenny Servo, Dawn Breaker; Jen White, University of Kentucky; Moderator: Marybeth Edeen, ISS National Lab Office, NASA

In 1925 Cecilia Payne theorized that the composition of stars, the sun in particular, was mostly hydrogen and not heavy metals. She was

This session presents how scientific training opens opportunities to careers by the bench and beyond (in public and private sectors), what skills are in demand, and what opportunities are available at IBM and Booz Allen. ___________________________________________

Session 4A: Access to Federal Labs

Speaker: Rick Shindell, Federal Laboratory Consortium for Technology Transfer, Zyn Systems Moderator: Mahendra Jain, Kentucky Science and Technology Corporation ‐ KSEF

This presentation provides an overview of the Federal Laboratory Consortium for Technology Transfer, and numerous ways academic and business groups can engage the technology resources and expertise available within the more than 500 Federal laboratories across the US. There are many opportunities to enhance projects and programs through the Federal laboratories – from licensing technologies (in order to commercially development them for US and international markets) to teaming with Federal laboratory scientists on technology development projects.

Information about Cooperative Research and Development Agreements (CRADAs), licensing agreements, partnership agreements, and upcoming events and opportunities to meet Federal laboratory technology transfer representatives will be shared. ___________________________________________

Session 4B: Imagination Powering Local Economies: The Role of University Research and Technology Development in Fostering Growth of Local Economies

Speaker: Justin Anderson, Wisconsin Alumni Research Foundation Moderator: Mehdi Yazdanpanah, NaugaNeedles

“We need to out‐innovate, out‐educate, and out‐ build the rest of the world…This is our generation’s Sputnik moment.” These words, from President 17

SESSION SUMMARIES

research studies, by opting to start a family. Jen has a successful research track and has created a network of supportive peers and positive female role models that has allowed her to balance academic and family life.

Lisa Sobolewski, building on her undergraduate degree in mathematics and minor in physics, learned engineering the “hard way.” After a spending five years in industry managing government engineering efforts, she joined the federal government where she’s been managing high‐risk, high pay‐off R&D programs for the past 27 years. Not satisfied with the technical side of things, Lisa returned to school in 2000 and earned her MBA. Lisa laughs and says, “I figured that after getting a strong‐minded, independent daughter through high school, there was no MBA course in the world that could be as challenging!” ___________________________________________

Session 5B: Triangulation for Success: Navigating the FDA Approval, Academic Research, and NIH Granting Processes

Speakers: Daniel Wermeling, University of Kentucky Moderator: Ruth Voor, Vivorte

In this session Dan Wermeling will review the FDA regulations governing development and approval of drugs and drug delivery systems. Application of the regulatory framework to academic drug discovery and development will be described in two contexts. One context is to garner the funding necessary to conduct discovery and development research. The second is conducting the necessary preclinical research required to initiate human studies and perhaps proof of concept.

Integrating the development science with regulatory requirements and grant offerings is a considerable challenge to academic investigators, and the subject of this presentation. ___________________________________________

the first woman (or man) to receive a PhD in Astronomy from Harvard University. Cecilia was born in England and attended Cambridge University. But she decided to continue her studies at Harvard because she thought women scientists in the United States might be more accepted. She was committed to pursuing a career in Astronomy even though very few women astronomers were known. She worked for years under several eminences, including her husband, but finally in 1956 she was appointed Harvard Faculty, and later became the first woman head of a department at Harvard.

This story is one of many examples of American creativity and innovativeness. It also exemplifies strategies common to successful women scientists and entrepreneurs. Successful women, as Cecilia, set their goals at an early stage and align their everyday efforts towards that goal. Successful women are also pragmatic; they draw their plan on how to get from A to B and simply execute it. When facing barriers, pioneering and leading women will simply adjust. Successful women are always open to learning. However, there is a particularity of successful women that clearly distinguishes them from their male counterparts: their networks.

Women create support networks at every stage of their careers. The relationships they build are deep, meaningful, mutually beneficial, and rooted in deep trust. “Schmoozing” is not networking to leading women.

Join this panel of successful women and hear how their stories parallel that of Cecilia Payne.

Jenny Servo, was born in England, her immediate family was her support network, their mottos "Anything that is worth doing, is worth doing well".

Federal programs and program managers have been essential in helping build her business.

Prejudice “…has not been frequent, and it never stopped me.”

Jen White opted for a career in academia, then further challenged her career, and pessimistic 18

SESSION SUMMARIES

about you" and how to distinguish yourself! The number one question in an employer's mind will be how are you different than any other candidate?

Make a Resume goal oriented! It helps employers assess how you added value to just a research task. ___________________________________________

Sessions 5E: KY EPSCoR Subcommittee Breakouts

KY NSF EPSCoR Program: Ongoing Research Directors: John Connolly (former), University of Kentucky, and Rodney Andrews (current), University of Kentucky

This breakout session will offer short presentations on the currently funded Track I and Track II Research Infrastructure Initiative (RII) awards.

Projects supported by the awards fall under the areas of: Cyberinfrastructure (CI), nanomaterials, bioengineering, ecological genomics, data management, and modeling of water‐quality sensors in lakes and streams. The presentations will include progress on the existing work, future goals, metrics and timelines for the remainder of the award periods.

NASA KY Space Grant and EPSCoR Program: Research and Activities Director: Suzanne Smith, University of Kentucky Associate Director: Janet Lumpp, University of Kentucky

The NASA breakout session is a joint meeting of the NASA Kentucky Space Grant Consortium and EPSCoR Programs. This breakout session will feature a review of the past year's activities and awards, along with presentations from the Science PI’s for the three NASA EPSCoR Research Area Awards in Kentucky.

The NASA EPSCoR Research Area Awards are competitively awarded at the national level and are the largest awards available through the NASA EPSCoR program.

Session 5C: Competitive Grantsmanship in a Tight Federal Budget: Strategies for Success

Speaker: Anna Palmisano, Department of Energy, USDA, and Department of Defense (retired) Moderator: Nancy Martin, University of Louisville

Scientists are facing one of the tightest funding environments in over 20 years, as Congress and the President struggle to reduce the federal deficit.

While science and technology are recognized as drivers of economic well‐being, many competing priorities are vying for a decreasing pool of available funds.

In this session, Dr. Palmisano will draw from her experience at the Department of Energy, the U.S. Department of Agriculture, the Department of Defense, and other federal agencies to share strategies to position scientists to be more competitive. This presentation’s topics will include how to work effectively with agency program managers, how to understand and address requests for applications, and how to write competitive proposals that appeal to reviewers. She will also address some of the changing program trends in Washington, DC, and the need to diversify and expand funding sources. ___________________________________________

Session 5D: Lost in Translation

Speaker: Jason Levin, Vault Inc Moderator: Aman Singh Das, Vault Inc

What your resume does not say might be the reason for your demise ... or at least the reason you will not get as many calls back from potential employers.

Jason Levin will present the art of writing a competitive resume during "Lost in Translation..

He has reviewed some of the resumes from this year’s conference registrants and will use those resumes as examples on how your resume is "an opportunity to engage employers into talking 19

SESSION SUMMARIES

equally well to business planning as it does to battle, for it is the forethought and strategic vision that helps you transform your team and develop a successful plan.

Dr. Jenny Servo’s presentation will provide practical and engaging tips on how to conduct strategic planning and market research – essential pre‐ requisites for developing and executing an excellent business plan. ___________________________________________

Session 7: Protecting Your Technology During the Commercialization Process

Speaker: Stephen C. Hall, Esq. Stoll Keenon Ogden PLLC Moderator: Blaine Ferrell, Dean and Professor Ogden College, Western Kentucky University

The technology world is an elaborate ecosystem.

Rarely does an innovator conceive, develop, and take an invention to market without the benefit of solid relationships with other organizations.

Research partnerships, licenses, non‐disclosure/ non‐competition agreements, and consulting agreements are just some of the kinds of contracts that these relationships are centered around.

However, these private contracts, which are often necessary in forming those important relationships on the path to commercialization, may limit the innovator’s ability to capitalize on the technology to its full potential.

This presentation examines three cases in which the innovators entered into various private contracts while developing or commercializing their technologies. Later, after patents were granted on the inventions, legal disputes arose over the rights and obligations created by those contracts. The ownership of the patents and the right to use information to develop competitive products were at issue in these disputes.

The goal of this presentation is to show how purposeful and careful contract drafting can be

KY DOE EPSCoR Program: NEW and Existing Research Opportunities Chair: Eric Grulke, University of Kentucky

The Federal DOE EPSCoR program has released a solicitation calling for $4 million in new Implementation Awards. This breakout session will discuss the funding objectives and requirements for this new opportunity and provide feedback on preparing a response to the solicitation. Secondly, the session will discuss needed elements for the current Implementation Group’s final report.

Thirdly, in a closed session, the subcommittee chair and PI’s will discuss re‐budgeting for the three year renewal which was recently awarded to the current Implementation group.

KY NIH‐IDeA Sub‐committee Inaugural Session Director: Nigel Cooper, University of Louisville

Kentucky currently has nine ongoing multi‐million dollar NIH Institutional Development Awards (IDeA). Eight of the awards are for Centers of Biomedical Research Excellence (COBRE). Four each are located at the University of Louisville and the University of Kentucky. One award is for a Statewide IDeA Network of Biomedical Research Excellence (INBRE) hosted by the University of Louisville. This breakout session will bring together the nine COBRE and INBRE research groups in an inaugural meeting. INBRE/COBRE PI’s will give 15 minute presentations on their Centers and Networks. Then discussions will be held to facilitate collaboration among the programs on the topics of summer student placement, core laboratories, and bioinformatics needs. ___________________________________________

Session 6: Business Planning and Market Research

Speaker: Jenny Servo, Dawn Breaker Moderator: Vickie Yates Brown, Nucleus

“Plans are nothing. Planning is everything.” This quote from General Dwight Eisenhower applies 20

SESSION SUMMARIES

used to avoid such situations and foster certainty over the ownership of valuable patents.

"Protecting Your Technology…" will be presented

by Stephen C. Hall, a registered patent attorney with Stoll Keenon Ogden PLLC, and a former research chemist. The presentation examines the interplay between the patent system and the various private contracts that are often necessary in the development of technology.

21

SESSION SUMMARIES

22

SPEAKER AND MODERATOR BIOS US competitiveness in automotive battery manufacturing.

Dr. Andrews received his Bachelor of Science degree in Chemical Engineering from Michigan State University (2994) and his Ph.D. in Chemical Engineering from the University of Kentucky (1999). He is a licensed Professional Engineer in Kentucky. ___________________________________________

VICKIE YATES BROWN – is an attorney with extensive experience in health care law and finance, specializing in privacy, security, and technology transfer. She has worked closely with the University of Louisville Foundation and President James Ramsey planning development, building partnerships and securing Tax Increment Finance (TIF) funding for Nucleus. She was named president and CEO of Nucleus in the spring of 2008.

Vickie Yates Brown is an experienced leader in health and sciences law and business. Currently, Brown serves as the Chair of the Health and Life Sciences Practice group at Frost Brown Todd. She is the chairwoman of the Health Law Section of the American Bar Association. She is Vice Chair of the Health Enterprises Network. And, she sits on the editorial board of the BNA Health Law Reporter.

Vickie Yates Brown has served on the Advisory Council for the Human Genome Project and National Institute of Diabetes, Digestion and Kidney Disease as part of the National Institutes of Health. She has delivered numerous national and international presentations and co‐authored three publications on health care law and government regulation. ___________________________________________

JOHN W.D. CONNOLY – is the Director of the Center for Computational Sciences, and Professor of Physics and Astronomy at the University of Kentucky. He is also the recently retired Project Director for the Kentucky NSF EPSCoR Program.

John has over 30 years of teaching and consulting experience. He has over 90 technical publications in mathematical physics, computational methods,

JUSTIN ANDERSON – is an Intellectual Property Associate for University of Wisconsin‐Madison Alumni Association Research Foundation (WARF).

Justin manages the intake of new inventions, application preparation, and patent prosecution of physical and life science technologies in the areas of chemistry, engineering, biotechnology and medical devices.

WARF was created in 1925 to patent and license the discoveries of UW‐Madison researchers. WARF manages 800 pending and 1,200 issued U.S. patents. It offers more than 1,000 technologies for licensing and maintains more than 380 active commercial license agreements. It also holds equity in 40 UW‐Madison spinoff companies.

Justin holds a B.S. in Chemical and Biological Engineering and a B.S. in Biochemistry, both from UW‐Madison. He is a registered Patent Agent with engineering experience in process design, optimization, chemical analysis and project management. ___________________________________________

RODNEY ANDREWS – is the Director of the University of Kentucky Center for Applied Energy Research. His research interests include production of fuels and chemicals from coal and other fossil resources, thermochemical conversion processes for coal and biomass, and carbon fiber production and use. He is an Associate Professor in the Department of Chemical and Materials Engineering.

Dr. Andrews has directed major multi‐university and industry‐academic collaborative projects. He has published more than 65 peer‐reviewed journal articles and four book chapters. He has been granted five patents, is on the Honorary Editorial Advisory board for the journal Carbon and currently serves on the Kentucky Statewide STEM Education Taskforce. Dr. Andrews served as Interim Director of the Kentucky‐Argonne Battery Manufacturing Research and Development Center, a joint venture between the Commonwealth of Kentucky and Argonne National Laboratory focused on improving 23

SPEAKER AND MODERATOR BIOS Livestock Care and Standards Commission. Since 2007 she has served on the National Advisory Board for Research, Extension and Economics; this board advises the Secretary of the US Department of Agriculture on national research priorities. ___________________________________________

AMAN SINGH DAS – is the Senior Corporate Responsibility Editor with Vault.com. An IEMA‐ certified CSR Practitioner, Aman is the author of Vault's CSR blog: In Good Company, where she focuses on connecting career paths with CSR, sustainable business practices, employee engagement, diversity & women leadership in the workplace, and how increasing debate and engagement of these practices translates into recruitment and strategic development at companies. She also writes for Forbes’ CSR blog and CNBC’s blog on Executive Careers. Formerly with The Wall Street Journal, Aman is a New York University alumnus. She was named among 2010’s Top 100 Thought Leaders in Trustworthy Business Behavior by Trust Across America, ranked No. 4 in HRExaminer’s Top 25 HR Digital Influencers for 2011, and is widely read and syndicated on global websites such as 3BL Media,SustainabilityForum.com, CSRwire’s Talkback blog, and Boston College Center for Corporate Citizenship’s (BCCCC) blog In Good Company. She is a board member of the National Association for Asian MBA’s ERG Council and is a firm believer that only informed professionals can lead business and the global economy into the next century. ___________________________________________

MARYBETH EDEEN – is the International Space Station National Lab Manager for NASA. The goal of the National Lab Office is to use the unique environment and capabilities of the International Space Station for research and technology development in ways that benefit the American people. She joined NASA in 1989 where she worked on Life Support System development for 12 years, both advanced technologies for Lunar and Martian base applications and systems compatible with microgravity for use on the International Space

materials science, molecular physics, and theoretical chemistry. ___________________________________________

NIGEL G.F. COOPER – is Professor and Vice Chair Research Anatomical Sciences and Neurobiology, with a joint appointment in Ophthalmology and Visual Sciences, at the University of Louisville School of Medicine. He is the Director of the NIH’s INBRE Program in Kentucky. He is also Director of the Bioinformatics, Biostatistics, and Computational Biology Core for the NIEHS‐funded Center for Environmental Genomics and Integrative Biology. Nigel is currently funded by the NEI for research in eye diseases. He has 30 years of teaching in Neuroscience, and over 60 publications in peer‐reviewed journals and book chapters related to neuroscience and eye research. He is a member of the recently organized National Association of IDeA Principal Investigator’s Association (NAIPI). ___________________________________________

NANCY COX – is the Director of the Kentucky Agricultural Experiment Station and Associate Dean for Research in the College of Agriculture at the University of Kentucky. Dr. Cox’s research area is reproductive physiology of farm animals and she has been involved in consulting with producers and animal health companies. In 1998‐1999 she co‐ chaired, with Senator Robert Dearing, the Task Force on the Environment for the Mississippi Legislature; this task force conducted a year‐long study on the scientific issues related to environmental regulations on large swine farms.

Dr. Cox joined UK in 2001, and her duties include oversight of Experiment Station state and federal research budgets. She is responsible for the college grants office that manages approximately $30 million per year in external awards. She represents the College of Agriculture in a partnership with a newly established federal laboratory in Lexington, the USDA Agricultural Research Service Forage‐ Animal Production Research Unit. Dr. Cox represents the College on most Kentucky agricultural commodity boards and the Kentucky 24

SPEAKER AND MODERATOR BIOS Station. In 2001, she began managing hardware development work for the ISS, specifically the hardware required to support a crew of 6 on board.

This included life support, habitability, and exercise hardware. Ms. Edeen has been the Manager of the International Space Station’s National Laboratory Office for the past 2 years.

Ms. Edeen holds a Bachelor of Science degree in Chemical Engineering from the University of Texas and a Masters degree in Chemical Engineering from Rice University. ___________________________________________

BLAINE FERRELL – is Dean of Ogden College of Science and Engineering at Western Kentucky University, Director of the Applied Research and Technology Program of Distinction (ARTP), and a Board Member of the Kentucky Science and Engineering Foundation in addition to other state boards. The ARTP program has faculty and students working in interdisciplinary teams to help constituents meet applied research and technical challenges. The ARTP has worked as a research development catalyst with high‐level companies in the Central Regional Innovation and Commercialization Center at the WKU R&D Center to expand existing companies and create new ones.

These partnerships have created many more applied research projects for our students. ___________________________________________

DON FITZPATRICK – is the General Manager, for Global Cisco Alliance, and Senior State Executive, Kentucky, IBM Corporation. Don re‐joined IBM in November 2001, as Vice President, Global Cisco Alliance, with responsibility for IBM’s overall strategy, direction, and business relationship with Cisco. Under Fitzpatrick’s leadership, IBM’s business with Cisco has grown into a multi‐billion, cross‐divisional partnership; with IBM now being recognized as one of Cisco’s largest global systems integrators and a top technology provider for their line of networking products. In recognition of this, he was promoted to General Manager in January 2008, and continues to work closely at CEO and senior executive levels across both companies to

effectively drive this complex, multi‐faceted relationship on a global basis.

Fitzpatrick was a founding member of the Louisville chapter of The Executive Committee, a global network of CEOs, is a past Director of the Greater Louisville Economic Development Partnership, and served as Greater Louisville Inc.’s Executive‐in‐ Residence during 2001. He currently serves as IBM’s Senior State Executive for the Commonwealth of Kentucky, is on the Board of Directors of the Greater Louisville Logistics Network, and is a member of University of Louisville’s Logistics and Distribution Institute (LoDI) Advisory Board. He graduated from Syracuse University in 1980, with a Bachelor of Arts degree from the Maxwell School of Citizenship and Pubic Affairs, and has attended several advanced management programs at Harvard University and Babson College. He resides in Louisville, Kentucky with his wife and three children. ___________________________________________

STEPHEN FLEMING – is Vice Provost, Enterprise Innovation Institute at Georgia Tech. A venture capitalist with a degree in theoretical physics, Stephen Fleming has more than 13 years of private equity experience at the general partner level. Prior to his venture capital career, he spent 15 years in operations roles at AT&T Bell Laboratories, Nortel Networks, and LICOM – a venture‐funded startup.

An Atlanta native and summa cum laude graduate of Georgia Tech, he is active in the “alternative space” industry — an investor in three private aerospace companies and is a founding member of the Space Angels Network. He also serves on the boards of trustees for the Spiritual Living Center of Atlanta and for Tech High School, a charter high school emphasizing science, math and technology in urban Atlanta. Stephen Fleming is a member of the IEEE, the American Physical Society, the Optical Society of America and a number of regional technology organizations. ___________________________________________

25

SPEAKER AND MODERATOR BIOS ERIC A. GRULKE – has been the Associate Dean for Research and Graduate Studies in the College of Engineering at the University of Kentucky since 2003. In addition, he is the Director of the Electron Microscope Center. He joined the University of Kentucky as Chair of the Department of Chemical and Materials Engineering in 1993.

Dr. Grulke started an academic career at Michigan State University (1978) including three years as the College of Engineering’s Associate Dean for Research. He worked in new process R&D for BFGoodrich Chemical from 1975‐78. Dr. Grulke received Chemical Engineering Degrees from The Ohio State University (BS 1971, MS 1972, Ph.D. 1975).

Dr. Grulke also served as a Congressional Engineering Fellow in the office of Senator Carl Levin, Michigan. He is the author of more than 130 articles in leading technology journals and has mentored students to 40 graduate degrees. He is a Senior U.S. Editor of Polymer Handbook, now in its fourth edition. Dr. Grulke has been awarded three U.S. patents and is a registered professional engineer in the states of Ohio and Michigan.

Dr. Grulke is a current member of the Board of Directors, Engineering Research Council, American Society of Engineering Educators, serving as Secretary‐Treasurer. Since 2005, he has served as the Chair of the Kentucky DOE‐EPSCoR Statewide Committee. Dr. Grulke is also a member of the U.S. Technical Advisory Group on Standards for Nanotechnologies. He has been an evaluator for ABET since 2000, a proposal reviewer for NSF, DOE, NASA, and the USDA, and a manuscript reviewer for more than 20 journals.. ___________________________________________

STEPHEN C. “STEVE” HALL – is a member with the law firm Stoll Keenon Ogden PLLC. Prior to law school, he graduated with Honors in Chemistry from the University of Louisville, and worked as an R&D chemist with Reliance Universal (now Akzo Nobel). His legal practice involves helping clients to create, protect, and exploit their intellectual

property, and helping clients to manage their legal risks. His technical areas include chemical, pharmaceutical, life sciences, nanotechnology, genetics, medical devices, and electromechanical devices.

Steve speaks regularly to scientific and clinical audiences as well as various industry organizations.

He has presented talks to the American Bar Association, the American Psychiatric Association, the Federation of Defense and Corporate Counsel, the Defense Research Institute, and the Diagnostic Conference, in addition to various other speaking engagements. Steve’s speaking topics have included genetics and pharmacogenomics, nanotechnology, chemical patents, gene patents, commercialization of inventions, and clinical trials.

Since 2007, Steve has been recognized each year in Best Lawyers in America® in the area of biotechnology law. ___________________________________________

MAHENDRA K. JAIN – is the founding Executive Director of the Kentucky Science and Engineering Foundation (KSEF) and Vice President of the Kentucky Science and Technology Corporation (KSTC) in Lexington, Kentucky. In his present position, Dr. Jain is fostering partnerships between academic, industrial and state institutions in building and expanding Kentucky’s scientific and engineering capacity to attract external research funds from all sources, to help advance research ideas and to build a pipeline of technologies. In addition, Mahendra has proactively pursued the growth of the Federal SBIR and STTR Programs in the state through outreach and state‐funded assistance programs, was the recipient of the Tibbetts Award in 2006, and currently also serves as the Science Director for Kentucky Space.

Before joining KSTC, Dr. Jain worked at several universities in the USA, Europe, and India. He also worked at MBI International, a biotechnology R&D company in Lansing, Michigan where he was involved in technology development and transfer.

26

SPEAKER AND MODERATOR BIOS

GREGORY M. JONES – is an Associate with Booz Allen Hamilton, a worldwide strategy and technology consulting firm. Dr. Jones is a Senior Defense Research Analyst, consulting for the DoD/DoE in the area of advanced electronics. Prior to his time at Booz Allen, Dr. Jones spent three years as a NRC Postdoctoral Research Fellow at the US. Naval Research Laboratory, leading an investigation in the area of spin‐transport in semiconductor heterojunctions.

Dr. Jones received his Bachelor of Science degree in Physics from the College of William and Mary (2001) and his Ph.D in Electrical Engineering from the University of Maryland (2006). At the University of Maryland, Dr. Jones investigated ballistic/mesoscopic semiconductor systems as well as single and few electron semiconductor devices for quantum computing applications. ___________________________________________

KRIS KIMEL – is President and a founder of the Kentucky Science and Technology Corporation (KSTC) a non‐profit company with an international reputation for designing and implementing a range of innovative initiatives. Over the 21 year life of KSTC dozens of projects have been funded by diverse supporters involving corporations, private foundations, state and federal governments.

KSTC funds important R&D and technology commercialization projects at Kentucky universities. It also designed and manages the Kentucky Enterprise Fund (KEF), an early‐stage venture fund which currently holds over 60 equity positions in innovation‐driven Kentucky companies.

Kris Kimel is a leader behind the vision and implementation of Kentucky Space, a nonprofit enterprise focused on the design, development and application of entrepreneurial and educational space platforms. He is also the founder of the international IdeaFestival (IF), a world‐class event that attracts leading and highly diverse thinkers from across the nation and around the globe to

After receiving his Ph.D. in microbiology in 1972, Dr. Jain received and managed research grants and contracts in several million dollars from federal, state and industrial sources. He is the author of 11 United States patents, one Canadian patent and over 120 research papers, articles and book chapters. ___________________________________________

DIANA JERKINS – is a National Program Leader with the USDA National Institute of Food and Agriculture (NIFA). She has managed competitive programs in the areas of mitigation and adaptation to climate change, managed ecosystems, invasive species, small and mid‐sized farm prosperity, rural development, and Native American outreach. She has leadership responsibilities for development and management of NIFA competitive Climate Change and Food Systems Integrated Programs. As co‐ leader of the Science for Sustainability working group, she leads agency‐wide activities supporting sustainable and organic agriculture programs.

Interagency activities are in the areas of Long Term Agricultural Research programs (LTAR), chairing the NIFA Ecosystem Services Working Group, and NIFA liaison to the NASULGC Board on Natural Resources, USA National Phenology Network, and OSTP Ecosystem Service Task Team. She has lead efforts in the development of new programs within CSREES such as the Beginning Farmer and Rancher Development Program (BFRDP) and an interagency program with EPA on Enhancing Ecosystem Services from Agricultural Lands.

Prior to joining NIFA, Dr. Jerkins directed the Center for Regenerative Studies at Cal Poly Pomona in Pomona California. Her graduate work was at the University of Georgia with degrees in Agronomy and Entomology. She consults internationally on sustainable agriculture issues.

Professional activities and professional associations include Agronomy, Crop, and Soil Science Societies; Ecological Society of America; Federal Environmental Stewardship and Sustainability working group; and USDA Sustainable Development Council.

27

SPEAKER AND MODERATOR BIOS for the United States Olympic Committee in the division of Sports Science and Technology.

Liz received Bachelor of Arts in Biology from the University of Pennsylvania (1993) and her Master’s degree in Kinesiology and Health Promotion, with a specialty in Biomechanics, from the University of Kentucky in (1996). ___________________________________________

F. RICHARD KURZYNSKE – is the Director of the Kentucky Statewide EPSCoR Program. He shares this position part‐time with his other responsibilities as a principal partner of the Cyrus Partnership, LLC, and Brigadier Development, LLC, business investment groups. Rick’s background includes a decade in Chicago as a senior manager with a natural gas energy consortium that principally invested in the development and commercialization of energy‐related technologies.

Rick moved to Lexington in 1992 when he became an officer of the Mason & Hanger Corporation, a Forbes 500 Company which, prior to its sale, principally provided technical and manufacturing services to the Federal government. Rick has been responsible for two high‐tech startup companies and has been an officer/director of more than 12 companies. He has an MBA from the Keller Graduate School of Business and a Ph.D. in Civil Engineering (energy and environmental focus) from the University of Tennessee‐ Knoxville. ___________________________________________

MARIA LABREVEUX – joined the Kentucky Science and Technology Corporation (KSTC) in February 2007 and is the Senior Program Manager for the Kentucky Science and Engineering Foundation (KSEF). Dr. Labreveux manages the KSEF Research and Development Excellence (RDE) and the Kentucky Commercialization Fund (KCF) programs, for which KSTC receives funding from the Commonwealth of Kentucky through a contract with the Council on Post‐Secondary Education.

Maria brings research and grants management experiences from the Delaware State University

explore and celebrate innovation, imagination and game‐changing ideas. ___________________________________________

ROBERT L. KING – became the third president of the Kentucky Council on Postsecondary Education January 16, 2009. He previously served as president and CEO of the Arizona Community Foundation, a statewide charitable foundation with a strong focus on education, economic development, and scientific research. Mr. King is the former chancellor of the State University of New York, one of the largest comprehensive systems of universities, colleges, and community colleges in the world. Mr. King is very active in community service and has volunteered and served on numerous boards and organizations. He also has served on the White House Commission on Presidential Scholars; the Education Committee of the U.S. National Commission for the United Nations Educational, Scientific, and Cultural Organization (UNESCO); an advisor to the Middle State Commission on Higher Education regarding reauthorization of the Higher Education Act in Congress; the board of directors of the National Soccer Hall of Fame; and the board of trustees of A.T. Still University, a specialized university dedicated to training people for the health care professions, in Kirksville, Missouri, and Mesa, Arizona.

Mr. King received a Bachelor of Arts degree from Trinity College in Hartford, Connecticut (1968) and Juris Doctor from the Vanderbilt University School of Law (1971). He is married to Karen, his wife of 32 years, and they have four grown children. ___________________________________________

LIZ KNAPP – serves as the Assistant Director of the Kentucky Statewide EPSCoR Program. Liz joined the Kentucky Science and Technology Corporation (KSTC) in November 2002 as Program Manager for the Kentucky Science and Engineering Foundation (KSEF) and for Kentucky EPSCoR (Experimental Program to Stimulate Competitive Research).

Previously she worked as a Research Analyst at the University of Kentucky studying Neuroscience, and 28

SPEAKER AND MODERATOR BIOS France, Jason was the President of the Rotary Foundation Alumni Association in France (the first non‐French national to hold the position.) He has a Bachelor of Science degree in Business Administration and a minor in French from Rowan University.

Jason strongly believes in giving back to the community. He sits on the Board of Directors of the United Way of the National Capital Area (United Way NCA) and is the Chair of the Young Leaders Society of United Way NCA. In addition, Jason gives pro bono lectures on university campuses as well as at outplacement centers on interviewing skills, career management, and job search strategies. ___________________________________________

JANET K. LUMPP – has been a professor of Electrical and Computer Engineering at the University of Kentucky since 1993. She received her Ph.D. from the University of Iowa, and earned her BS and MS degrees in Metallurgical and Materials Engineering from Purdue University.

Dr. Lumpp’s research and teaching abilities span a wide range of topics from lasers and microelectronics to K‐12 education and carbon nanotubes. Dr. Lumpp conceived, developed, and leads the Kentucky Electronics Education Project (KEEP), a program that uses microelectronics as a theme to connect core concepts in science, technology, engineering, and math (STEM) education. She also leads the Education and Public Outreach efforts for Kentucky Space, including high‐altitude balloon‐launch workshops for K‐12 teachers.

Dr. Lumpp established the Laser Processing Laboratory in ECE at UK and oversees the electronic assembly facilities. She recently concluded a four‐year research contract from the Army Research Lab on Advanced Carbon Nanotechnology with UK colleagues and collaborators at four other institutions. Dr. Lumpp has been the principal investigator on several KY NASA EPSCoR grants, KSGC awards and

where she worked as an Assistant Professor before moving to Kentucky. Maria secured over $2 million in two and half year period at DSU for her research and teaching from federal and state agencies such as the United States Department of Agriculture, National Recourses Conservation Services, the Cooperative State Research, Education and Extension Services, the National Science Foundation, and University of Delaware. Dr. Labreveux is an active member of the Early Career Professional Division of the Agronomy and Crop Science Societies of America and a contributor to the society's monthly newsletter. Dr. Labreveux received her M.S. and Ag. Engineering degrees in Argentina, and her Ph.D. in Agronomy‐Plant Science from The Pennsylvania State University. ___________________________________________

JASON LEVIN – is a District Manager with Vault.com, Inc. Vault.com gives millions of high‐ potential students and professionals the competitive edge ‐‐ to land a great job or make a critical career decision. Jason works with AmLaw 100 law firms, Fortune 100 corporations, consultancies, accountancies, and federal agency employers to raise engagement and interaction of their online employer brand to Vault.com’s audience.

Prior to joining Vault.com, Jason worked in brand management for Unilever on the Dove Global team developing cross‐regional innovations in the anti‐ aging category. Jason also was a business development manager for QS World Grad School promoting LLMs globally, a management consultant for RSM Salustro Reydel Management, and an analyst with Andersen Consulting (now Accenture).

Jason received his MBA from the Georgetown McDonough School of Business. While at Georgetown, Jason worked overseas on brand management consulting projects for Unilever Sri Lanka and Pepsi Vietnam. Additionally, Jason was a Rotary Ambassadorial Scholar and studied for an international business degree (DEUF) from Université Jean Moulin Lyon 3. While living in 29

SPEAKER AND MODERATOR BIOS Novariant, SiOnyx and TerraGo Technologies.

Previously Mirmira was Principle at SpaceVest and prior to that, served as a Manager of Technology Evaluation and Acquisitions at Boeing. Mirmira was also a Senior Technologist at Applied Materials, where his efforts led to over $100M in revenue and the company capturing significant market‐share in the chemical‐mechanical and planarization business.

Mirmira graduated with distinction from Bombay University in Mechanical Engineering, and subsequently obtained a M.S. and Ph.D. in Mechanical Engineering from Texas A&M University. Mirmira’s research on thermal properties of dielectric thin‐films and organic composite materials led to two patents and over fifteen publications in leading scientific journals and professional conferences. He also holds an MBA, specializing in finance and economics, from the University of Chicago. Mirmira is on the Advisory Board of the Mechanical Engineering Department at Texas A&M University. ___________________________________________

JEFF MOSEY – serves as the Associate Director and Program Administrator for the Kentucky National Science Foundation (NSF) EPSCoR where he has worked for the past ten years. The Kentucky NSF EPSCoR is a multi‐million dollar state/federal partnership to develop programs of research excellence in Kentucky.

Jeff graduated with his Bachelor’s degree in Business Management and minor in Economics from the University of Kentucky in 1997. From 1999‐2001 Jeff worked in the UK Office of Sponsored Projects Accounting, where he oversaw the financial administration of several of the institution’s research grants and contracts.

Jeff received his MGA from the UK Gatton College (2003) with a concentration in Management Information Systems. He has spent time working in private industry in Indiana and Kentucky, and completed two years of his Ph.D. coursework in the UK Martin School for Public Policy and

fellowships. She also has a strong funding record with the National Science Foundation (NSF) through a Graduate Fellowship, Research Initiation Award, CAREER Award, and as a faculty participant in the two NSF IGERT graduate training grants awarded to the University of Kentucky. ___________________________________________

NANCY C. MARTIN – is a professor of Biochemistry and Molecular Biology at the University of Louisville. Throughout her career, she has applied state of the art molecular biological techniques to make distinguished contributions in the areas of mitochondrial biogenesis, RNA enzymology, and protein targeting. She holds an honorary degree from the University of Umea and has been elected a Fellow by the American Association for the Advancement of Science.

She served as Senior Vice President for Research at the University of Louisville from 1996 to 2006 and oversaw a tremendous expansion of research infrastructure and a more than fourfold expansion of extramural funding. She implemented a number of new policies and procedures supportive of research and technology transfer, including creation of a Technology Transfer Office. In addition to her current faculty responsibilities, she serves on the ORAU Board, the Board of the Northern Kentucky University Research Foundation, Pradama (a biotech startup), the leadership team of the Kentucky Girls Collaborative in STEM (science, technology, engineering, and math), on the Kentucky Statewide STEM Taskforce, and chairs the Kentucky Statewide EPSCoR Committee. ___________________________________________

SRINI MIRMIRA – is focused on commercializing and accelerating the deployment of technology developed by ARPA‐E funded entities. Before joining ARPA‐E, Mirmira was a Partner at RedShift Ventures, an early‐stage venture capital firm specializing in spin‐offs from universities, research centers, and corporations. Mirmira served on the Board of Directors of several RedShift Ventures portfolio companies including Imaginova, 30

SPEAKER AND MODERATOR BIOS

by Gov. Steve Beshear in 2008 to oversee Kentucky’s energy, environmental protection and natural resources programs, Dr. Len Peters has developed and implemented Kentucky’s first comprehensive strategic energy plan to address the state’s growing demands for energy in an environmentally sustainable and economically effective manner. He also has been instrumental in creating a unique partnership opportunity among the Argonne National Laboratory, the Commonwealth of Kentucky, and two of the state’s leading research institutions, the University of Kentucky and the University of Louisville to advance lithium battery manufacturing research and development.

Dr. Peters served at the Battelle Memorial Institute, a leading nonprofit applied science and technology development company, where he was senior vice president and director of the Pacific Northwest National Laboratory. Dr. Peters has held senior academic and administrative positions at leading universities, including the University of Kentucky and Virginia Tech.

Dr. Peters holds a doctorate in chemical engineering from the University of Pittsburgh and has been recognized as a distinguished alumnus by that university. He has been recognized for his achievements with honors ranging from the National Science Foundation Award to the Oak Ridge Associated Universities' Outstanding Leadership Award. ___________________________________________

JENNY C. SERVO – is the founder and president of Dawnbreaker, a professional services firm specializing in commercialization assistance to advanced technology firms. Since 1990, Dawnbreaker has conducted both Phase I and Phase II commercialization assistance programs for the Department of the Navy, the National Science Foundation, the Department of Energy, the National Institutes of Health, the National Institute of Standards and Technology, and NASA. Dawnbreaker has worked with more than 3,500 SBIR and STTR companies that have cumulatively

Administration. He is a member of the Beta Gamma Sigma International Honor Society and completed continuing professional education training for strategic planning from the National Association of State Boards of Accountancy. ___________________________________________

ANNA PALMISANO – recently retired from the U.S. Department of Energy (DOE) where she served as Associate Director of Science for Biological Environmental Research. At the DOE, she was responsible for an annual budget of $600 million, supporting basic research in bioenergy, systems biology and genomics, and climate and environment science. She also served as the Deputy Administrator for Competitive Programs in the U.S. Department of Agriculture (USDA) where she led the National Research Initiative. Previously she was a Program Manager in the Office of Biological and Environmental Research where she developed and managed research programs in bioremediation, carbon cycling, and genomics. Dr. Palmisano has also served as a Program Manager and acting Division Director for Biomolecular and Biosystems Sciences and Technology in the Office of Naval Research. She co‐chaired the US‐ European Commission Working Group for Environmental Biotechnology from 1995 to 2010, and led the Interagency Microbe Project from 2004‐ 2006.

Dr. Palmisano received a B.S. degree in Microbiology from the University of Maryland, and the M.S. and Ph.D. degrees in Biology from the University of Southern California. She was an Allan Hancock Fellow at the University of Southern California and a National Research Council Fellow in planetary biology at NASA‐Ames Research Center. She currently works as a science and technology consultant in biotechnology and bioenergy, agriculture and environment, and competitive grantsmanship. ___________________________________________

LEN PETERS – is an internationally renowned chemical engineer with demonstrated leadership in research, academia and management. Appointed 31

SPEAKER AND MODERATOR BIOS transfer field, Shindell manages the support contract for the Federal Laboratory Consortium (FLC) Far West and Mid‐Continent regional networks, working with more than 100 of the nation’s premier federal laboratories. He was honored in 2006 with an SBIR Tibbetts Award for outstanding contributions to the SBIR program. ___________________________________________

SUZANNE WEAVER SMITH – (Donald and Gertrude Lester Professor of Mechanical Engineering, University of Kentucky; Director, NASA Kentucky Space Grant Consortium and EPSCoR Programs) joined the UK faculty in 1990.

Her 20 years working in the aerospace industry started with modeling and testing the Fine Guidance Electronics of the Hubble Space Telescope at Harris Corporation in 1980. She has numerous NASA Center affiliations, including four summers at NASA Langley.

Suzanne received her Ph.D. at Virginia Tech for research on vibration‐based damage detection for structures such as the International Space Station, and her MS and BS degrees from Clemson University. She has collaborated on research projects and SBIRs with Boeing, Lockheed, ILC Dover, L‐3 Communications, NextGen Aeronautics, and others in the aerospace industry.

She was the lead advisor (with seven other UK faculty) on the BIG BLUE Mars Airplane, which involved over 300 university students and over 400 low‐altitude flight tests that demonstrated the feasibility of inflatable wings for extraterrestrial exploration. Technical developments of BIG BLUE have since been applied to DOD programs.

Dr. Smith is currently developing three modules for the NASA Space Systems Engineering Course (distributed nationwide). She is an award‐winning researcher and educator, with recognition as an NSF Young Investigator and two‐time winner of the UK CoE Henry Mason Lutes Award for Engineering Education. ___________________________________________

received in excess of $2 billion. Dawnbreaker also implements the Commercialization Pilot Program for NAVAIR. Dr. Servo specializes in the design of programs for Federal and State Agencies and in assisting small, advanced technology firms with business planning, market research, strategic planning, and commercialization plans. She has worked with more than 400 small businesses commercializing technology in fields as diverse as bioterrorism, genomics, software, sensors and photonics, telecommunication, medical instrumentation, resource recovery, imaging, and many others. Dr. Servo is the author on a series of three books on commercialization, including Business Planning for Scientists and Engineers (4th edition, 2005); Knock Their Socks Off: Making Winning Presentations to Investors; and ATP’s Commercialization and Business Planning Guide (1999). ___________________________________________

RICK SHINDELL – is President of Zyn Systems and is a long‐time SBIR advocate supporting small businesses, federal agencies, state outreach organizations, intermediaries, and advocacy groups. Shindell is perhaps best known for his hard hitting “SBIR Insider” newsletter which provides the SBIR community with news and critical information about the SBIR program, proposed legislation, successes, failures, and controversies. The SBIR Insider is read by thousands including small businesses, state intermediaries and providers, federal program managers, and many congressional staffers. Shindell also created and manages Zyn’s SBIR Gateway (www.zyn.com/sbir), a cross‐agency SBIR/STTR information website serving more than 5,000 users daily, who perform more than 45,000 SBIR topic searches per month across all agencies’ open SBIR/STTR topics. He has been a consultant and proposal reviewer to many agencies and organizations such as the SBA for their Federal and State Technology Partnership (FAST) and rural Outreach (ROP) programs, EPA’s environmental reach, National Technology Transfer Center (NTTC), Navy, NIST, NSF, West Virginia High Tech Consortium Foundation, and the DoD TechMatch program. In the federal technology 32

SPEAKER AND MODERATOR BIOS CYPHER™ and orchestrated the global launch of 2nd and 3rd generation drug eluting stents. She also expanded the strategic focus of her company by identifying and championing other percutaneous interventional opportunities: mitral and aortic valve repair and replacement, vein graft stenting, and vulnerable plaque diagnosis with local drug delivery platform design. Ruth now is the President and CEO of Vivorte, Inc., an orthopedic device commercialization company, focused on bringing innovative orthopedic technologies to market. ___________________________________________

DAN WERMELING – has more than 25 years of experience in clinical drug development and is responsible for directing ITI’s science and technology activities. He serves as a tenured Associate Professor at the University of Kentucky’s College of Pharmacy and was director of its Drug Product Evaluation Unit, a clinical pharmacology program, between 1990 and July 2001, when he chose to devote more time to ITI’s development.

He served as ITI’s Senior Vice President and Chief Operating Officer from July 2001 until August 2004, when he returned to his full‐time position at the University. Dr. Wermeling is the primary inventor of patented technologies to which ITI holds exclusive licensing rights. Dr. Wermeling has published nearly 60 research articles and also has served as a consultant to companies, government and academic institutions. He recently became a member of the National Institutes of Health’s Gene and Drug Delivery Systems grant review committee. He has started another company, Alcomed, which is focused on nasal drug delivery for treatment of suspected opioid overdose. ___________________________________________

JENNIFER WHITE – is an Assistant Professor in the Department of Entomology at the University of Kentucky. Jen received her PhD in Ecology, Evolution and Behavior from the University of Minnesota (2005) and was a post‐doctoral fellow at the University of Arizona.

Dr. White became an Assistant Professor in the Department of Entomology at the University of

ELISSA “LISA” SOBOLEWSKI – is the DHS SBIR Program Director. Ms. Sobolewski has over 25 years of experience managing high risk, high payoff R&D initiatives funded by the Departments of Homeland Security, Commerce and Defense. She joined the DHS Science and Technology (S&T) Directorate in January 2006, and became the DHS SBIR Program Manager in June 2006 and the DHS SBIR Program Director in January 2009.

Prior to joining DHS, Lisa held numerous management and technical positions at the National Institute of Standards and Technology (NIST) in Gaithersburg, MD. She was a Program Manager at DARPA for nine years, responsible for managing the RF and microwave/millimeter wave programs. Lisa also held positions at the David Taylor Naval Ship Research and Development Center, and at the Department of Defense Technology Analysis Office. She worked for McDonnell Douglas Astronautics Company (Engineering Services) on various government contracts supporting the USMC. Lisa is an IEEE member and a member of the IEEE Microwave Theory and Techniques Society. She holds a B.S. degree in Mathematics from Duquesne University, and an MBA from George Mason University. ___________________________________________

RUTH VOOR – Upon graduating from the United States Naval Academy in 1983, Ruth received her commission as an officer in the US Naval Supply Corps and served for 6 years. During her tenure as an officer, Ruth received numerous leadership awards including Naval Achievement, Naval Commendation medals and Service Warfare Officer Qualification. She joined Johnson and Johnson in 1989 and was recognized for her success by being promoted from night shift production supervisor to plant manager within three years. Ruth then moved into research and development roles of increasing responsibility and culminated this phase of her career by successfully bringing the first drug eluting stent to market: CYHPER™. Following this blockbuster global launch, Ruth transferred to strategic portfolio and product marketing. Here she was responsible for sustaining the success of 33

SPEAKER AND MODERATOR BIOS articles and papers published by organizations such as the New York Academy of Sciences, the Corporation for Enterprise Development, the Aspen Institute, the Southern Growth Policies Board, the Southern Technology Council, and FORMEDIA (Lisbon, Portugal). Trent has served as chair, co‐chair, or member of over 20 state, regional, and national committees, task forces, and councils. ___________________________________________

MEHDI M. YAZDANPANAH – is the CEO of NaugaNeedles LLC and an Entrepreneur Fellow of Kauffman Foundation. He holds a Ph.D. from University of Louisville (2006), where he co‐ invented room temperature self‐assembly of metal alloy nanostructures, which is the basis for the NaugaNeedles, which he founded in 2007. He also holds the B.S. degree in Physics from Sharif University of Technology and M.S. degree in Physics from the Beheshti University (2001), where he designed and fabricated a scanning tunneling microscope (STM).

Dr. Yazdanpanah’s current research involves constructing an Ultra Soft Atomic Force Microscope (USAFM) using Nano‐Cantilevers to image biological system under liquids, developing a nonmanufacturing tool to controllably grow arrays of metallic nanoneedles on selected location and orientation, and devising and demonstrating new applications of the NeedleProbes.

Mehdi is the recipient of the 2009 Vogt Innovation Award, including an unrestricted cash award, and the Kauffman Entrepreneur Fellow in 2010. Under his leadership, NaugaNeedles has achieved tremendous milestones including raising more than $2M in federal, state, and private funding; establishing the NaugaNeedles' manufacturing facility capable of producing more than 10,000 devices per year; selling NaugaNeedles products to more than 100 customers worldwide; and expecting to expand its customer base significantly in near future. He has published more than 15 papers in refereed journals and holds four US pending patent.

Kentucky in 2008. Her current research focuses on the ecological and behavioral ramifications of bacterial endosymbiont infection in insects. She also has two children, ages seven and five, and will share her perspective on balancing a family with an academic career. ___________________________________________

TRENT WILLIAMS – is Principal and CEO, Regional Technology Strategies, Inc., Chapel Hill, NC. Since 1976 has led numerous public policy and private development efforts in a wide range of economic development, business formation, developmental finance, industrial competitiveness, technology management, and strategic planning endeavors.

Current efforts at RTS include leading a project team to update Kentucky’s science and technology strategy for the Kentucky Science and Technology Corporation (KSTC) as well as leading an initiative to create a regional growth plan for eastern South Dakota that ties private sectors to existing and emerging research enterprise and talent assets with the regional universities. Most recently le led a five‐year project to assist the Governor’s Office of Montana implementing strategies to advance the state’s information technology and biotechnology sectors. He also recently led an RTS project to develop a strategic plan to foster university technology development and commercialization throughout Louisiana for the Board of Regents and the Louisiana Recovery Authority. He has also served as a Founding Director of eight technology‐ based companies, as well as a faculty member of a team formed from other technology compay CEOs and venture capitalists from the Research Triangle area to deliver a business launch course for faculty and graduate students at the University of North Carolina Kenan‐Flager Business School’s Center for Entrepreneurship and Technology Venturing.

Trent’s professional experience includes service in positions as Undersecretary of the Louisiana Department of Commerce, Executive Vice President of the Louisiana Partnership for Technology and Innovation, and Vice President and Research Director at Louisiana’s Gulf South Research Institute. He has authored numerous 34

POSTER PRESENTERS – IN ALPHABETICAL ORDER

PRESENTER Aly Abdelrehim

TITLE POSTER# 94 3D Imaging Dental Probe for Orthodontic Treatment

Buddika Abeyweera

Use of Photobleaching Technique to Understand the Effect of Photovoltage on the Stability and Efficiency of Organic Solar Cells

PRESENTER Karen Collins

44

TITLE POSTER# Search for Earth‐Like Planets 35 Outside Our Solar System Using Transit Timing Variations

Yinan Cui

Multiple Air Robotics Indoor Testbed (MARIT)

61

Thomas Dziubla

Endothelial Targeting of Antioxidant Polymer Nanoparticles for the Suppression of Vascular Oxidative Stress

8

Rosendo Estrada

Microfluidic Devices to Study the Effect of Atherogenic Flow Pattern on Cultured Endothelial Cells

15

Joyce Evans

Efficacy of Countermeasures to Cardiovascular Deconditioning in Men and Women During Simulated Moon and Mars Explorations

11

Joyce Evans

Cardiovascular Models of Simulated Moon and Mars Gravities: Head Up Tilt vs Lower Body Unweighting

10

Wafaa Fawzy

Preferential Hydrogen Bonding in the Superoxide‐ Water Radical Complex

51

Wafaa Fawzy

Ionic Hydrogen Bonding in the Superoxide‐HF Radical Complex

52

37

Sergey Artiushin

Isothermal Helicase‐ 9 Dependent DNA Amplification Assays for Detection of Bacterial Pathogens of Horses

Siddhartha Bhattacharyya

Vibration Monitoring and Analysis with Wireless Sensor Network (WSN) to Classify Vehicles Types

Siddhartha Bhattacharyya

Visualization of Kentucky Lake 66

Souvik Biswas

Externally Directed AMF‐ Triggered Release of Doxo‐ rubicin from Magnetic Carriers

Kevin Z. Brown

Cosmic X‐Ray Background 67 NanoSat (CXBN): An Improved Measurement of the Diffuse X‐ Ray Background

Chuanxi Cai

MG53 Mediated Muscle Membrane Repair

29

Lizbeth Campbell

Assessing Pollinator Food Sources and Phenology on Eastern Kentucky University’s Campus

14

Moises Carreon

Amino‐Functionalized SAPO‐ 34 Membranes for CO2 Separation

87

Eric Frederick

Effects of Non‐Oral Feeding on Infant Tongue Muscle Mass and Force

Janet Characterization and Activity Chakkamadathil of Mesoporous Titanosilicate Ccatalysts with Isolated Mohandas Titanium Sites Generated by Surfactant Complexation

45

Hichem Frigui

Ensemble Hidden Markov 60 Model Classifiers for Detecting Explosive Devices

Jared T. Fulcher

79

Ezra Clark

Mass Production of Metal Oxide Nanowires

102

Thermomechanical Characterization of Environmentally Conditioned Shape Memory Polymers

Daniel Cleland

Science Gateway‐Mowic: Modern Web Interface for Clusters

68

Jason Fuller

Matrix Isolation Spectroscopy of Copper‐Naphthalene

88

74

Cuticle Plays an Important Role in Basal as well as Induced Defense Against Bacterial and Fungal Pathogens

26

Self‐Assembled Nanoelectromechanical System for Detecting Piconewton Forces

Qing‐ming Gao

Robert Cohn

73

28

35

POSTER PRESENTERS – IN ALPHABETICAL ORDER

PRESENTER Said Ghabrial

TITLE POSTER# Use of a Virus‐Based Vector for 30 Stable Protein Expression and Gene Function Studies in Soybean

PRESENTER Xu Jiang

TITLE POSTER# Fabrication of Nanoporous 90 Nickel as an Alternative to Raney Nickel

Henry Kaplan

Progressive Rod Degeneration in Miniature Pig Model of Retinitis Pigmentosa

31

Haluk Karaca

Novel Shape Memory Materials for Aerospace and Biomedical Applications

80

Bruce Kessler

99

Novel Reaction Purification 104 Cartridges and Nanopalladium Pellets for the Chemical and Pharmaceutical Industries

Peaklet Analysis: Software for Fast, Accurate, and Automated Analysis of Spectrum Data

Sowmya Kolli

46

Issam Harik

Strengthening Steel Beams with Ultra High Modulus CFRP Laminates

103

Fundamental Studies of Light Absorption in Vertical Nanowire Arrays

Ashok Kumar

Closed System Container Wireless Monitoring

101

Cindy Harnett

Out‐of‐Planet Electrodes for Microfluidic Pumps

16

Aleck Leedy

Autonomous Robot Design Competition

50

David Haws

Support Vector Machine Based 1 Test for Incongruence between Sets of Trees in Tree Space

Serhiy Leontsev

Novel Lead‐Free Piezoelectric Ceramics in the Solid Solution BiFeO3‐BaTiO3

76

Jeff Hay

Passive, Non‐Contact Remote Sensing of Displacement Using High Dynamic Range Optical Sensors

89

Wen Li

Multistep Sparse Matrix Strategies for Information Retrieval on Large Datasets

69

Preclinical Development of NEXT Tissue Revitalization Technology for Degenerative Disc Disease

2

Advanced MEMS Grayscale Lithography Mask Generation Software

83

Thomas Hedman

James Loomis T.M. Lucas

Low‐Cost Conductivity Sensor with Data Logging

53

Anna Hellmann

Cellular Morphology as a Response to Nutrients and Rapamycin in Ustilago Maydis

17

Ali Mahmoud

Autonomously Robotic Tour Guide

62

Nanoscale Bubble Valves on CNT Membranes for Chemical Energy Storage

77

Earth‐Based Calibration of the S‐Band Synthetic Aperture Radar Onboard NASA’s Lunar Reconnaissance Orbiter

63

Bruce Hinds

Benjamin Malphrus

Kyle Hord

Numerical Investigation of A Corrugated Dragonfly Airfoil

12

Mark A. Miller

59

Jeremy Hornbeck

Signposts of Planets Around the T‐Tauri Star GM Aur

13

Investigation of the Relationship Between Freestream Turbulence and Klebenoff Modes

Arthur Hunt

Polyadenylation of Stored mRNA During Seed Germination

3

Steven Mims

Sustaining Our Seafood: Video on Reuse Technology for Fish Production

105

Doug Jackson

Wireless Temperature Sensing System for Children

97

E.V. Moiseeva

Light‐Powered Nanoparticle‐ Mems Hybrid

18

Amirhossein Ghasemi

Shape and Vibration Control of 48 Membrane Structures under Servo‐Constraints

Julio Gutierrez

Certified Reference Standards and Stable Isotope Internal Standards for Equine Medication Regulation

Gerald Hammond

95

36

POSTER PRESENTERS – IN ALPHABETICAL ORDER

PRESENTER Monica Moreno

TITLE POSTER# Characterization and Catalytic 92 Properties of Pd and PdAg Monolayer Protected Clusters

Mai‐Dung Nguyen

Microfluidic Cell Arrays for High‐Throughput Culture

19

Anoop Rao Paidipally

Dynamic Data Extraction, Data Visualization and Customized Statistical Analysis with Application to the Kentucky Mesonet Data

56

Thomas Pannuti

Archival Study of the X‐ray Spectra of Blazars with the Chandra X‐ray Observatory

64

Vahidreza Parichehreh

Exploiting Osmosis for Size‐ Based Separation of Blood Cells into Subpopulations Using Microfluidics

4

Kunal Pharas

Solar Thermal Powered Knudsen Gas Pump

84

Alex Porter

Endothelial Cell Processes at the Intracellular Level on PEG Hydrogels with VEGF

20

Spandana Pulla

High Temperature Polymer Matrix Composites for Aerospace and Space Applications

81

Jonathan Quiton

Predictive Models for Pollutant Source Identification Using DNA Biomarkers and PCR Readings

58

Jonathan Quiton

Some Results in Modeling Single Household Daily Power Demand

57

Stephen Rankin

PRESENTER Wes Ryle

TITLE POSTER# Thomas More Telescopes in 65 the Classroom

Gregory Schardein

Electron‐Beam‐Induced Deposition of Metal Nanostructures from Liquid Precursors

93

Christopher Schardl

Elimination of Ergot Alkaloid Production in a Forage Grass through Genetic Manipulation of its Symbiotic Fungus

5

Christopher Schardl

Kentucky Initiative in Ecological Genomics

22

Robert Shapiro

Spinal Posture and Gait‐ Related Vertebral Body Motion in Normal Older and Normal Younger Female Subjects

32

M Keith Sharp

Computer Modeling of Biomechanical Mechanisms of Orthostatic Intolerance

39

Hainsworth Shin

Fluid Pressure Selectively Influences Endothelial Cell‐ Related Tubulogenic Activity

40

Tim Smith

Kentucky Institute for Aerospace Education: Creating the Pipeline to Further Student STEM Opportunities

49

Navaladian Subramanian

Titania/Bucky Paper Composites for Photocatalytic Dye Degradation and Photoelectrochemical Water Splitting

47

Quartz Crystal Microbalance 43 Investigation of Cellulase Binding, Activity and Inhibition on Model Cellulose Films

Qian Sun

Undertaking Behavior in Termites

21

Sridhar Sunderam

Noninvasive Scoring of Mouse Sleep and Behavior

41

Jeremy Rathfon

Selectively Stimulated Self‐ Assembly of Polymer Thin Films into Nanoscale Suspended Structures

91

Sridhar Sunderam

Automated Detection and Characterization of Hypoxia‐ Ischemia Induced Seizures in Neonatal Rats

42

Thomas Roussel

Kentucky Nanonet: Connecting Kentucky's Micro/Nano Community

70

Shigeo Tamiya

Mechanisms Involved in Retinal Surface Scar Formation

6

Harry Russell

Hematite Nanowire Arrays for Photoelectrochemical Water Splitting

82

Ziyou Tang

Preferential Hydrogen Bonding in the Superoxide‐ Water Radical Complex

54

37

POSTER PRESENTERS – IN ALPHABETICAL ORDER

PRESENTER Douglas Taylor

TITLE POSTER# Exosomal RNA and Protein 98 Expressions Differentiate Pregnancies Destined to Deliver Preterm

Steven M. Truscott

Clinical Mass Spectrometry to Quantify Therapeutic and Endogenous Cardenolides with Anti‐Cancer Properties

23

Mike Unuakhalu

Networked Cooperative Autonomous Mission Control

71

Luis Urbina

3D Data Visualization of Bee Hive Cluster Using Sensor Net

72

Michael Voor

Simple Modeling to Study Prediction and Prevention of Fragility Fractures of the Hip

Rodrigo Wiederkehr

PRESENTER Zhang

TITLE POSTER# Leukocyte Mechanosensitivity

Justin Zhang

Numerical Simulation for the 34 Hydrodynamic Focusing Effect in the Microfluidic Coulter Counter

Qunwei Zhang

Cigarette Smoke Extract Enhanced Ambient Ultrafine Particle‐Induced Oxidative Stress in Endothelial Cells

38

Yuchen Zhang

Ionic Hydrogen Bonding in the Superoxide‐HF Radical Complex

55

33

Joe Zhou

Functional Analysis Of Genes Involved In The Caste Differentiation In Termites

96

Adsorption of Chlorophyll a on to Hydrophobic and Hydrophilic Surfaces Using Broadband Spectroscopy with Single‐Mode Integrated Optical Waveguides

36

Shifeng Zhu

EDS1 and Salicylic Acid Act Redundantly to Regulate Oleic Acid‐Mediated Defense Signaling

27

Phil Womble

Broadcast Methods for the Elimination of Random Anomalous Peak Loads

100

Qingliu Wu

Tuning the Pore Structure of Surfactant‐Templated Mesoporous Titania Films

78

Lu Wu

High‐Resolution Pulsed‐Field‐ 75 Ionization Ion Spectroscopy of Transition‐Metal‐Oxide Clusters

Angle‐Multiplexed Waveguide‐Resonance Sensor of High Sensitivity and Nano‐ Second Time Resolution

85

Bangbo Yan

Hybrid Organic‐Inorganic Polyoxometalate Materials

86

Ling Yuan

Development of Hyperactive 7 DNA Transposases by Directed Evolution

Justin Zhang

Numerical Simulation for the 24 Hydrodynamic Focusing Effect in the Microfluidic Coulter Counter

Identification of Parameters to 25 Quantitatively Assess

Han Xue

Xiaoyan

38

POSTER ABSTRACTS

Keywords: phylogenetic trees, non‐parametric hypothesis test, support vector machines, supervised clustering ___________________________________________

2. Preclinical Development of NEXT Tissue Revitalization Technology for Degenerative Disc Disease Thomas P. Hedman*(1,2); Paul Slusarewicz(1), Bryan Kirking (1), Justin Toungate(1) (1)Orthopeutics, (2)Biomedical Engineering and Neurosurgery Departments, University of Kentucky

The demonstrated ability of certain non‐toxic chemical agents to provide fast‐acting, long lasting, and inexpensive repairs to load‐supporting tissues like the intervertebral disc provides the opportunity for unique new therapeutic options. Genipin‐based Nonsurgical EXogenous crosslink Therapy (NEXT) has been shown to address the core, underlying factors contributing to degenerative disc disease— nutritional deficiency and mechanical insufficiency of the disc—while also addressing known pain generators directly by reducing joint instability, reducing disc bulge under load, increasing tear resistance, and providing a level of adhesion of adjacent tissue layers to resist release of catabolic agents from degraded discs. NEXT has also been shown to dramatically and immediately improve tissue mechanical properties including strength, toughness, and fatigue resistance. Recent testing supported by the Kentucky SBIR Matching Funds has shown that NEXT has the ability to maintain disc hydration by increasing retention of water attracting molecules, a critically important function for pain‐free load support. Other recent pre‐clinical testing was directed at quantifying dose response including evaluating the effect of repeated treatments. In addition, worst‐case neurotoxicity testing confirmed that there were no treatment related effects following epidural injections in rats.

Newly formed strategic alliances with UK, Hagyard Equine Medical Institute, and Coldstream Laboratories have positioned Orthopeutics to launch a new entity, Equinext, to investigate and commercialize NEXT‐based treatment options for

BIOSCIENCES

1. Support Vector Machine Based Test for Incongruence between Sets of Trees in Tree Space David C. Haws*(1), Peter Huggins(1), Eric M. O’Neill(2), David W. Weisrock(2), Ruriko Yoshida(1) (1)Department of Statistics, University of Kentucky, (2)Department of Biology, University of Kentucky

The increased use of multi‐locus data sets for phylogenetic reconstruction has increased the need to determine whether loci under consideration have evolved under similar evolutionary processes (e.g. the neutral coalescent) or whether a gene tree or set of gene trees significantly deviate from the phylogenetic patterns of other genes. Such unusual gene trees may have been influenced by other evolutionary processes such as selection, gene duplication, or horizontal gene transfer. Motivated by this problem we propose a nonparametric goodness‐of‐fit test for two empirical distributions of gene trees, and we developed the software GeneOut to estimate a p‐value for the test. Our approach maps trees into a multi‐dimensional vector space and then applies support vector machines (SVMs) to measure the separation between two sets of trees. We use a permutation test to assess the significance of the SVM separation. To demonstrate the performance of GeneOut, we applied it to the comparison of gene trees simulated within different species trees across a range of species tree depths. When applied to DNA sequence data simulated from different sets of gene trees, results in the form of receiver operating characteristic (ROC) curves indicated that GeneOut performed well in the detection of differences between sets of trees with different distributions in a multi‐dimensional space.

Furthermore, it controlled false positive and false negative rates very well. The non‐parametric nature of our statistical test makes it an applicable test for any scenario where evolutionary or other factors can lead to trees with different multi‐ dimensional distributions.

39

POSTER ABSTRACTS

Keywords: unadenylated RNA, seed germination ___________________________________________

4. Exploiting Osmosis for Size‐Based Separation of Blood Cells into Subpopulations Using Microfluidics Vahidreza Parichehreh*, Srikanth Suresh Kumar, Kranthi Kumar Bhavanam , Rosendo Estrada, Palaniappan Sethu University of Louisville

Blood leukocytes or white blood cells (WBCs) provide an ideal sample to monitor systemic changes and understand molecular signaling mechanisms involved in disease processes. Blood samples need to be processed to deplete contaminating erythrocytes or red blood cells (RBCs) and sorted into different WBC sub‐ populations prior to analysis. This is typically accomplished using immune‐affinity protocols which result in undesirable activation. An alternative is size based sorting which by itself is unsuitable for WBCs sorting due to size overlap between different sub‐populations. To overcome this limitation we investigated the possibility of using controlled osmotic exposure to deplete and/or create a differential size increase between WBC populations. RBCs and WBC sub‐populations isolated using density gradient separation were studied using a microfluidic device and the size increase and lysis of blood cells following exposure to deionized (DI) water was monitored. Time lapse microscopy confirms depletion of RBCs within 15 seconds and creation of > 3 µm size difference between lymphocytes, monocytes and granulocytes. A flow through device was also used to expose different WBCs to DI water for 30, 60 and 90 seconds to quantify cell loss and activation.

Results confirm preservation of ~100% of monocytes, granulocytes and loss of ~30% of lymphocytes (mostly CD3+/CD4+) with minimal activation. These results indicate feasibility of this approach for monocyte, granulocyte and lymphocyte (sub‐populations) isolation based on size.

equine musculoskeletal health.

Keywords: collagen crosslinking, adhesive properties, glycosaminoglycan retention, dosing, neurotoxicity ___________________________________________

3. Polyadenylation of Stored mRNA During Seed Germination Arthur G. Hunt*(1), Liuyin Ma(1), A. Bruce Downie(2) (1)Department of Plant and Soil Science, University of Kentucky, (2)Department of Horticulture, University of Kentucky

Seed germination is a critical control point in the plant life cycle, demarcating the transition from the stage most impervious to that most susceptible to the environment. Crop production, weed management, and the establishment and range of native‐ and invasive‐species all depend upon whether and when seeds in a population complete germination and how quickly and uniformly they do so. Thus, mechanisms that regulate germination are of great importance. Germination is sensitive to inhibitors that affect cellular poly(A) polymerases, yet surprisingly insensitive to more general inhibitors of transcription by RNA polymerase II. In concert with this, seeds may accumulate a sizeable population of non‐ polyadenylated mRNAs. This body of work frames the hypothesis that is the subject of this project.

This hypothesis holds that the polyadenylation of stored mRNAs is vital for seed development and germination.

To test this hypothesis, polyadenylated and unadenylated RNAs that accumulate in the course of seed germination are being characterized. For this, a novel deep‐ sequencing approach has been developed. Using this approach, the 3’ ends of polyadenylated and unadenylated RNAs that are present in dry seed have been studied. The results confirm that populations of unadenylated RNAs do accumulate in the seed, and that high‐throughput sequencing can be used to study unadenylated RNAs in the course of seed germination.

40

POSTER ABSTRACTS

Keywords: forage grass, tall fescue toxicosis, alkaloid biosynthesis, symbiosis, endophyte ___________________________________________

6. Mechanisms Involved in Retinal Surface Scar Formation Shigeo Tamiya*, LanHsin Liu Departments of Ophthalmology and Visual Sciences, and Biochemistry and Molecular Biology, University of Louisville

Fibrotic diseases are often initiated by epithelial cell damage. Upon damage epithelial cells undergo epithelial‐mesenchymal transition (EMT) to assume a migratory mesenchymal phenotype. In cases that result in fibrosis, such mesenchymal cells are known to further differentiate into myofibroblasts.

Aberrant and persistent induction of myofibroblasts is believed to cause fibrotic diseases. Numerous studies have shown that transforming growth factor‐beta (TGF‐ß) plays a critical role in this fibrotic process. Within the eye, formation of fibrotic scarring on the surface of the retina involves EMT and myofibroblast transformation of retina pigment epithelial (RPE) cells. Similar to other fibrotic diseases, TGF‐ß has strongly been implicated to play an important role in such retinal surface scarring. However, the precise mechanism is still not clear, and therefore, in this project, experiments were conducted to understand the mechanisms involved in this potentially blinding disease. An in vitro culture model using primary cultured RPE sheets were utilized to understand the changes that occur during EMT and myofibroblast transformation in the presence or absence of TGF‐ß.

Immunocyto/histochemical staining and western blot analyses was used to determine expression, localization and/or activation status of various proteins. Our data shows that cell‐cell contact is the primary regulator of EMT, with TGF‐ß failing to induce EMT in differentiated RPE cells maintaining intact cell‐cell contact. Interestingly, however, TGF‐ß plays an important secondary role downstream of EMT in inducing myofibroblast transformation.

Keywords: osmosis, blood leukocytes, microfluidic ___________________________________________

5. Elimination of Ergot Alkaloid Production in a Forage Grass through Genetic Manipulation of its Symbiotic Fungus Simona Florea(1), Timothy D. Phillips(2), Christopher L. Schardl*(1) (1)Department of Plant Pathology, University of Kentucky, (2)Department of Plant and Soil Sciences, University of Kentucky

Tall fescue is an agronomically important cool‐ season grass grown extensively across the United States. Stand longevity and high forage yields, along with good resistance to various stresses, depend in part on the presence of the symbiotic fungus, Neotyphodium coenophialum (endophyte).

This mutualistic relationship, however, can have a detrimental effect on cattle performance due to the ergot alkaloids produced by N. coenophialum.

Therefore, we are eliminating the ability of an N. coenophialum strain to produce ergot alkaloids by deleting dmaW, the gene for the first step of the ergot alkaloid‐biosynthesis pathway. The endophyte has two copies of dmaW, and we have eliminated dmaW2 by replacing it with a foreign marker gene, which we then removed. We then attempted the same strategy to eliminate dmaW1, but were unsuccessful after screening more than 600 transformants. However, by sequencing the 95‐Mb genome of N. coenophialum, we revealed that dmaW1 is part of a telomeric cluster of ergot‐ alkaloid biosynthesis (EAS1) genes. This result presented us with an alternative and more feasible approach to remove the entire EAS1 cluster. For this purpose we have designed a transformation vector to recombine with lpsA1, the 10‐kb EAS gene on the centromeric side of the cluster, and by subsequent spontaneous or Cre‐recombinase‐ mediated removal of the selectable marker, to leave a telomere‐protected chromosome end. The resulting endophyte strain is expected to lack ergot alkaloids as well as the foreign marker genes used in its construction, making it suitable for introduction into tall fescue cultivars.

41

POSTER ABSTRACTS

Kentucky‐based biotech company, Transposagen Biopharmaceuticals, Inc. One of the research focuses of the PI’s is the DE of DNA‐binding proteins, while Transposagen is a company commercializing mobile DNA technologies and a leader in the functional manipulation of transposons including PB. The breadth of interests of the collaborative team provides experience and expertise in areas including protein engineering by DE, high throughput screening, and functional characterization of hyperactive transposases.

Keywords: __ ___________________________________________

8. Endothelial Targeting of Antioxidant Polymer Nanoparticles for the Suppression of Vascular Oxidative Stress David Cochran, Paritosh Wattamwar, Rich Eitel, Kimberly Anderson, Thomas Dziubla* Department of Chemical and Materials Engineering, University of Kentucky

Vascular oxidative stress is a key pathological process in a variety of disease states (e.g., ischemia – reperfusion injury, hypoxia, and acute lung or renal injury). Oxidative stress is characterized by the formation of a wide range of reactive oxygen species, which can cause severe DNA, protein, and lipid damage leading to cellular dysfunction and death. This type of injury results in a degenerative cycle of propagative damage. It is possible to suppress this injury through the addition of free radical scavengers, which can intercept oxidation of cellular components and thereby attenuate this damage. However, in order for this therapy to be effective, a therapeutic dosage of antioxidants must be delivered to the site of injury. We have previously demonstrated the use of an antioxidant polymer, poly(trolox), to suppress general vascular oxidative stress1. In this work, we evaluate the ability of cell adhesion molecules (PECAM‐1) targeted poly(trolox) nanoparticles to suppress injury in a human umbilical vein endothelial cell (HUVEC) model. By incorporating targeting antibodies on the surface of these nanoparticles we

Keywords: fibrosis, TGF‐beta, retina ___________________________________________

7. Development of Hyperactive DNA Transposases by Directed Evolution Sanjay Singh(1), Eric Ostertag(1,2), Ling Yuan*(1) (1) University of Kentucky and (2) Transposagen Biopharmaceuticals, Inc.

Transposons are a proven, efficient and cost‐ effective technology for genome modification.

Transposon technology has great commercial potential in areas such as gene therapy, therapeutic protein production, and transgenesis. However, in order for transposon technology to be commercially viable in these areas, it will be necessary to create “hyperactive” transposases, enzymes that can mobilize transposons with extreme efficiency. We propose to apply directed evolution (DE) technology to create hyperactive transposases. DE comprises two discrete components: first, genetic diversity is created through the production of a library of genetic variants, and second, the library is evaluated through genetic selection and/or high‐throughput screens to identify variants with the desired function(s). DE differs from natural evolution in two key aspects: i) DE is performed under controlled selection pressure for predetermined functions and ii) in DE, “non‐natural” functions of practical use may be derived through appropriate selection schemes. Therefore, DE is a powerful tool that is ideal for the creation of hyperactive transposases. For this proposed project we will engineer a newly characterized transponsase, PiggyBac (PB). One major advantage of using PB for transgenesis is that it can carry a very large cargo, able to easily deliver sequences in the 10‐15 kB. High quality random or targeted mutant libraries will be generated and screened using flow cytometry‐based transposition assays. Selected variants will serve as parents for subsequent rounds of evolution in which positive mutations will be recombined. This project promotes and capitalizes on interactions and collaborations between scientists from University of Kentucky and a 42

POSTER ABSTRACTS

10. Cardiovascular Models of Simulated Moon and Mars Gravities: Head Up Tilt vs Lower Body Unweighting VI Kostas(1), R Shapiro(1), MB Stenger(2), CF Knapp(3), S Wang(3), JM Evans* (3), A Diedrich(4) (1)Kinesiology and Health Promotion, University of Kentucky, (2)NASA JSC, (3)Center for Biomedical Engineering, University of Kentucky, (4)Vanderbilt University

Introduction: Models of cardiovascular responses to postural changes in reduced gravity environments should be evaluated prior to exploration class space missions. We compare two models (head‐up tilt, HUT, vs body un‐weighting, LBPP) to simulate Moon, Mars and Earth gravities. We hypothesized that indexes of segmental (thorax (THX), abdomen (ABD), upper (UL) and lower (LL) leg) and cardiac output (CO) volume shifts, as well as regulatory (blood pressure (BP), heart rate (HR), vascular resistance (VR)) responses to standing would be similarly reduced by LBPP and HUT. Methods: Mean values of cardiac variables were recorded from 21 subjects during 20 minute sessions while supine (simulation of space flight), standing at 100% Body Weight (BW) (Earth), and in the Alter‐G trainer (AG) at 40% (Mars) and 20% (Moon) BW. An additional test was conducted on a tilt table while supine and tilted at 80°, 20°, 10° HUT. Results (Mixed Model, p<0.05): Differences between the two models were found for SBP (higher in AG, 13 mmHg ± S.E.M.), DBP (higher in AG, 11 mmHg ± S.E.M), SV (lower in AG, 7 ml ± S.E.M.), VR (higher in AG), THX (higher in AG) and ABD Impedances (lower in AG). Conclusion: Body weight unloading via both LBPP and HUT resulted in cardiovascular changes similar to those anticipated in actual reduced gravity environments. The LBPP model (Alter‐G) has the advantage of providing a study environment that allows dynamic activity at reduced body weight, however, significant increase in BP in Alter‐G gives the HUT model an advantage.

Keywords: weightlessness simulations, blood pressure regulation ___________________________________________

see significant attachment of polymeric carriers to endothelial cells as compared to untargeted polymer nanoparticles. This targeted delivery system also demonstrates the ability to suppress oxidative stress in a cellular model.

Keywords: biomaterials, targeted delivery, oxidative stress ___________________________________________

9. Isothermal Helicase‐Dependent DNA Amplification Assays for Detection of Bacterial Pathogens of Horses Sergey C. Artiushin*, John F. Timoney Gluck Equine Research Center, University of Kentucky

Strangles caused by Streptococcus equi and abortion and uveitis caused by Leptospira interrogans are common diseases of horses in Kentucky. Control of these infections will be facilitated by development of rapid and sensitive assays performed beside the animal or in the veterinarian’s office. Simple and portable assays for detection of S. equi and pathogenic leptospira have been developed based on detection of se18.9 (S. equi) and IS287 (L. interrogans) specific sequence using an isothermal helicase‐dependent amplification (tHDA) reaction followed by visual detection of the amplicon in a disposable lateral flow cassette or in precast agarose gels using a portable E‐Gel iBase Power System. Experimental kits have been produced and evaluated. The specificity and sensitivity of tHDA assays were similar to that of PCR when applied to specimens from horses. Tests require neither expensive equipment nor extensive training of personnel and provide a practical alternative to PCR assays for detection of S. equi and pathogenic leptospira in clinical samples.

Keywords: streptococcus, leptospira, horse, tHDA ___________________________________________

43

POSTER ABSTRACTS

UK GCRC USPHS # M01RR02602.

Keywords: weightlessness, blood pressure regulation, gravity ___________________________________________

12. Numerical Investigation of A Corrugated Dragonfly Airfoil Kyle Hord, Dr. Yongsheng Lian Department of Mechanical Engineering, University of Louisville

Previous experimental studies on static, bio‐ inspired corrugated wings have shown that they produce favorable aerodynamic properties such as delayed stall compared to streamlined wings and flat plates at high Reynolds numbers (Re = 10^4).

The majority of studies have been carried out with scaled models of dragonfly forewings from the Aeshna Cyanea in either wind tunnels or water channels. In this study, the aerodynamics of a corrugated airfoil was investigated using computational fluid dynamics at a low Reynolds numbers of 1000, with an investigation of the complex vortex structures that form in the corrugated airfoil valleys and around the airfoil. The study shows that at low Reynolds numbers the corrugation does not provide any aerodynamic benefit compared to a flat plate geometery.

Instead, the corrugated airfoil generates more drag than the flat plates. A static structural analysis shows that the wing corrugation can increase the resistance to bending moments on the wing structure with reduced thickness and weight.

Keywords: dragonfly, MAV, low Reynolds, flight ___________________________________________

11.

Efficacy of Countermeasures to Cardiovascular Deconditioning in Men and Women During Simulated Moon and Mars Explorations JM Evans*(1), A Patwardhan(1), CF Knapp(1), S Wang(1), M Howarth(1), V Kostas(1), R Schneider(1), L Mohney(1), R Moore(1), L Krompak(1), M Haaga (2) J Smith, (3) SH Platts(3), MB Stenger(3), TT Schlegel(3), FB Moore(3), A. Diedrich(4) (1)Center for Biomedical Engineering, University of Kentucky, (2)NASA Ames, (3)NASA JSC, (4)Vanderbilt University

Our goal has been to develop a countermeasure to mitigate cardiovascular consequences of adaptations to microgravity during space missions.

In collaboration with NASA JSC, NASA Ames and Alter G Corp investigators, we conducted studies with the following results: A) Breast high compression garments prevent the increased incidence of orthostatic intolerance seen in the hypovolemia model of spaceflight. Mechanisms of action included better control of blood pressure through a return of more blood to the heart, requiring less need for activation of sympathetic neural reflexes. B) AlterG’s “G Trainer” can be used to model cardiovascular responses to standing and walking in Mars and lunar gravities. Controlling lower body positive pressure in the G Trainer offered the opportunity to reduce body weight and return standing stroke volume to supine levels at lower levels of sympathetic activity. In an outreach study, we determined that C) Diabetics with autonomic neuropathy were identifiable using noninvasive measures we developed in previous EPSCoR studies. Those indices pinpoint a failure of cardiovagal reflex regulation of blood pressure in diabetic neuropathy. In the final year, the same consortium of investigators are assessing 1) design of the Alter G seal, 2) effects of Alter G activity in subjects who are cardiovascularly deconditioned, and 3) effects of a short exposure of deconditioned subjects to artificial gravity using NASA Ames’ Human Performance Centrifuge. Supported by KYNASA EPSCoR WKU5612, NIH R01N539774 and 44

POSTER ABSTRACTS

14. Assessing Pollinator Food Sources and Phenology on Eastern Kentucky University’s Campus Nan Campbell Eastern Kentucky University Environmental Research Institute, Eastern Kentucky University

Creating habitats for pollinators is a multifaceted and dynamic process. Pollinators need three season blooms cycles in order to survive winters and other harsh climactic events, such as drought. In order to create efficient, sustainable, and effective planting plans and guidelines to address the need for three season bloom cycles, an in‐depth understanding of existing habitats is necessary. In my project, a survey of Eastern Kentucky University’s existing pollinator friendly plant species was performed.

This data was then transferred to GIS maps in order to create a visual database of existing pollinator habitats. Through these visuals, pollen deserts in late summer and early fall were identified. With the information collected from this project, campus officials and students may be able to work together to create a pollinator friendly landscape. This data may also be applied in updating forage maps, so that a greater understanding of climate change’s effects on phenology is gained. In this process, pollinator support and advocacy becomes more effective as we gain an understanding of Kentucky’s pollinator landscape with the ultimate goal of creating effective relationships between people, habitats, and pollinators.

Keywords: sustainability, ecology, pollinators ___________________________________________

15. Microfluidic Devices to Study the Effect of Atherogenic Flow Pattern on Cultured Endothelial Cells Rosendo Estrada*, Vahidreza Parichehreh, Mai‐ Dung Nguyen, Palaniappan Sethu Department of Bioengineering, Speed School of Engineering, University of Louisville

Atherosclerotic susceptible regions and the appearance of atherosclerotic lesions are found in

13. Signposts of Planets Around the T‐Tauri Star GM Aur J. Hornbeck*(1), C. A. Grady(2,3), A. Brown (4), T. Ayres(4), D. Apai(5), S. Brittain(6), J. M. Brown(7), K. Hamaguchi(8,3), Th. Henning(9), G. Herczeg(10), I. Kamp(11), M. Perrin(5), R. Petre(3), G. Schneider(12), M. Sitko(13), F. Walter(14), G. Williger (1)University of Louisville, (2)Eureka Scientific, (3)NASA's GSFC, (4)University of Colorado, (5)STScI, (6)Clemson University, (7)CfA, (8)UMBC, (9)MPIA Heidleberg, (10)MPE, (11)Kapteyn Institute RuG, (12)Steward Observatory, (13)SSI, (14)Stonybrook Univer

Circumstellar disks are not only a byproduct of star formation, but are also the place where planets form and migrate. The dominant gas‐phase constituent of disks early in their evolution is H2, and its lifetime in the disk limits the time available for gas giant planet formation and migration. It has been suggested that the larger dust grains are confined to the outer disk if the gap or cavity hosts bodies with M > 1 MJ, but because accretion continues onto the star, they must be companions with M < 6 MJ (D’Angelo et al., 2006; Lubow and D’Angelo, 2006; Masset et al., 2006; Rice et al., 2006). Here we present our continued multi‐ wavelength investigation of GM Aur, a T‐Tauri star which hosts a large disk with a central cavity of r = 20 AU. Gaps in transitional disks have been described as optically thin, however, this may not be the case should the disk host one or more planets that preferentially allow only small grains enter the cavity. A novel technique we have used to test this hypothesis has been PSF subtracted high resolution FUV imagery obtained with HST/ACS.

Keywords: circumstellar disks, transitional disks, exoplanets, planet formation, t‐tauri stars ___________________________________________

45

POSTER ABSTRACTS

This technique depends on the strain mismatch between the tensile stressed film (metal layer) and the compressive stress film (oxidized silicon layer).

The electrodes roll up with a well defined radius of curvature in the range of 100‐200 microns. The new development over our previous work is the ability to connect two different electrical signals to alternating electrodes using an insulating silicon nitride barrier that allows circuits to cross over each other without shorting. Electroosmotic (EO) micropumps are essential for low‐cost, power‐ efficient microfluidic lab‐on‐a‐chip devices used in diverse application such as analytical probes, drug delivery systems and surgical tools. EO pumps can use DC or AC electric field to drive the solutions through the microchannels. ACEO pumps have been developed since 1990s by several groups to address the drawbacks of the DCEO pumps such as the faradic reaction, gas bubbles and electrode dissolution. The original ACEO microfluidic pump was created with planar arrays of asymmetric electrodes at the bottom of the channel. This rolled‐up tube design improves on the planar design by including the channel walls and ceiling in the active pumping surface area of the device.

Keywords: microfluidic, strain, ACEO, pump ___________________________________________

17. Cellular Morphology as a Response to Nutrients and Rapamycin in Ustilago Maydis Anna R. Hellmann*, Jinny A. Paul, Michael H. Perlin Department of Biology, Program on Disease Evolution, University of Louisville

A unique attribute of Ustilago maydis is its ability to form galls on maize. This ability requires that the fungus switches from a yeast‐like budding form to a filamentous form. This switch also occurs in response to nutrient deprivation and other environmental cues. While the Target of Rapamycin (TOR) pathway plays an important role in nutrient sensing (as well as other celular processes) in some pathogenic fungi, its role in U. maydis currently remains unclear. This study investigates the role of the TOR pathway in the

locations of disturbed flow, where arteries divide or curve sharply. Regions of disturbed flow in vivo are associated with high rates of endothelial cells proliferation, apoptosis, failure to align to the direction of the flow, and increased expression of inflammatory mediators. A number of studies have attempted to recreate the flow patterns in vitro that mimic vascular regions of disturbed flow.

However, these studies have been done with the use of macroscale systems that provide non‐ homogeneous conditions and lack of sufficient throughput. In this work, we have fabricated microfluidic devices with grooves that recreate disturbed flow. Computational fluid dynamics simulation shows recirculation within the microgrooves and values of shear stress in the range to those found in atherosclerotic regions.

Endothelial cells were seeded in channels with and without (control) microgrooves. Cells exposed to laminar shear stress (control) were elongated, aligned in the direction of the flow and the f‐actin filaments oriented in the direction of the shear stress. In contrast, cells within the microgrooves exposed to the same inlet flow rate had cuboidal, cobblestone morphology, random orientation, disorganized f‐actin filaments, and showed increased apoptosis. These results demonstrate the ability of these devices to mimic in vitro, the in vivo atherogenic flow pattern. Evaluation of additional atherosclerotic markers is in progress.

Keywords: atherogenic flow pattern, disturbed flow, endothelial cells, in vitro, microfluidic. ___________________________________________

16. Out‐of‐Planet Electrodes for Microfluidic Pumps Yehya M. Senousy*, Cindy K. Harnett Department of Electrical and Computer Engineering, University of Louisville

This poster reports the fabrication process of a microfluidic tube lined with interdigitated electrodes. The entire inner wall becomes a surface for AC electroosmosis‐driven pumping. Self folding is the technique used to fabricate the electrodes.

46

POSTER ABSTRACTS

nanoparticles: inkjet‐style deposition from a Dimatix material printer and parylene micro‐ stenciling. Finally, the silicon substrate is isotropically etched to release the MEMS structure, using XeF2 etchant that is highly selective to silicon but has a little effect on organic materials.

Integration of the infrared‐resonant gold nanoparticles on bistable MEMS structures creates light‐driven hybrid actuators that react to narrow‐ band infrared light by heating, causing the MEMS device to bend through controlled thermal expansion. The bilayer bistable structure is a strained rectangular frame with two local minimum and short‐lived transition states and extremely rapid transition time (<<0.1 s) as observed during optical and scanning electron microscopy.

Switching from those local minima is determined by thermal expansion from local heating of the printed nanoparticle film and depends on uniformity of distribution, absorbance at the infrared laser wavelength. Actuation at laser power and thermal limits compatible with physiological applications will enable microfluidic pumping elements and fundamental studies of tissue response to three‐dimensional mechanical stimuli, artificial‐muscle based pumps and other biomedical devices triggered by tissue‐permeant infrared light.

Cardiac muscle studies are the target application for these light‐powered actuators.

Keywords: MEMS, nanoparticle, infrared ___________________________________________

19. Microfluidic Cell Arrays for High‐Throughput Culture Mai‐Dung Nguyen*(1), Kranthi K. Bhavanam(2), Awdhesh Kalia(3), Yongsheng Lian(3), Palaniappan Sethu (1) (1)Department of Bioengineering, University of Louisville, (2)Department of Mechanical Engineering, University of Louisville, (3)Department of Biology, University of Louisville

Microfluidic cell arrays (MCAs) offer an attractive platform for massively parallel integration of cell culture with multiple, complex inputs delivered

dimorphic switch in response to nitrogen limitation.

Two integral membrane proteins, Ump1 and Ump2, serve as ammonium transporters and Ump2, in particular, is normally required for U. maydis to switch to filamentous growth on low ammonium (SLAD). We show here that knock out or over‐ expression of ump2 in conjunction with TOR inhibition via rapamycin treatment, results in morphological changes at both the colony and cellular levels. While treatment of wild type or the ump2 mutant with rapamycin resulted in little or no morphological changes on rich or SLAD media, treatment of other mutant strains produced some dramatic changes in morphology. A strain overexpressing ump2 is filamentous even on rich media. Treatment of this strain with rapamycin led to misshapen or donut‐shaped colonies, reminiscent of the “don” mutants associated with cell‐separation defects. Additionally, TOR inhibition results in further morphological changes in the ump1‐ump2‐double mutant, generating a hyper‐filamentous phenotype on SLAD; this is in contrast to the tangled short filaments normally produced by this strain. These findings allow us to propose a model for the role of TOR in ammonium sensing and the dimorphic switch to filamentous growth.

Keywords: ustilago maydis, rapamycin, TOR, ammonium transporter ___________________________________________

18. Light‐Powered Nanoparticle‐Mems Hybrid E. V. Moiseeva*, T.M. Lucas, C.K. Harnett Department of Electrical and Computer Engineering, University of Louisville

Light‐actuated microelectromechanical (MEMS) bistable elements are built using a metal/oxide bilayer with a stress mismatch. In a hybrid design that uses gold nanoparticles for localized heating in response to infrared light, a nanoparticle solution is patterned onto the selected part of the device before releasing the structures from the planar substrate. We use two different printing methods to deposit solutions with pre‐synthesized 47

POSTER ABSTRACTS

apoptotic stimuli, have been associated with vascular endothelial growth factor, isoform 165 (VEGF165). Current research in the areas of biomimetics and tissue engineering has focused on developing polyethylene glycol (PEG) based biomimetic systems capable of initiating and sustaining angiogenesis in vitro. However, an in depth understanding of how endothelial cells respond at the molecular level to VEGF165 incorporated into such systems has not been clearly established in the literature. The goal of the current study was to determine the up‐regulation of pro‐angiogenic proteins in human umbilical vein endothelial cells (hUVEC) and human microvascular endothelial cells (hMEC) seeded on PEG hydrogels containing grafted VEGF165 and adhesion peptides (RGDS). The data suggest that the covalent incorporation of VEGF165 into PEG hydrogels proficiently up‐regulates the signaling proteins responsible for increases in endothelial cell proliferation, cell migration, and apoptosis survival.

Keywords: VEGF, angiogenesis, PEG hydrogels, endothelial ___________________________________________

21. Undertaking Behavior in Termites Qian Sun*, Xiangrui Li, Li Tian, and Xuguo Zhou Department of Entomology, University of Kentucky

Undertaking behavior is an essential adaptation to social life and important for colony hygiene. Unlike Hymenoptera social insects such as ants, in which undertakers remove dead colony members and place the carcasses in a refusal pile away from the nest. This study, however, a lower termite, Reticulitermes flavipes, showed distinctively different undertaking behaviors toward dead termite workers from different origins. Specifically, dead termites from an alien species, R. virginicus, were buried onsite by R. flavipes undertakers while a group of R. flavipes soldiers guarding the burial site; whereas, dead termites from R. flavipes, regardless of their colony origins (KY or OH), were pulled back into the nest by R. flavipes undertakers with few soldiers guarding the entrance. The

with in vivo–like temporal resolution. Variables like composition of culture medium, chemical and biological stimulus, and cellular interactions can be varied in a time dependent fashion within a single array. We developed a MCA platform that is applicable for any cell‐based study regardless of cell type or evaluation technique. MCA trapped cells in a confined area of low shear stress and when necessary exposing them to the fluid flow for extraction. Types of cells that can be cultured within the array depend on the surface properties of the wells. Cell adherent surfaces ensure 2D monolayer culture whereas cell repellant surfaces are ideal for suspension cell culture or for the formation of spheroid bodies for 3D cultures. To ensure scalable inputs and delivery of complex stimuli, each array had an integrated gradient generator for dose response studies and a flow encoded switch for time dependent delivery of secondary stimulus. Automation of the gradient generator and fluid encoded switch was accomplished by using programmable syringe pumps and LabView. Computational fluid dynamics (CFD) was used to model fluid flow, visualize streamlines and estimate shear stress as well as to estimate diffusional and convectional transport of molecules into the wells. This MCA provides a universal platform for high‐throughput studies compatible with any cell type or post‐culture analysis technique without minimizing functional complexity attainable using microfluidics.

Keywords: MCAs, CDF, platform, cell arrays ___________________________________________

20. Endothelial Cell Processes at the Intracellular Level on PEG Hydrogels with VEGF AM Porter*, CM Klinge, AS Gobin University of Louisville

Angiogenesis is a key biological response known to be involved in many physiological and pathophysiological situations. Three intracellular responses involved in the initial formation of new blood vessels, increases in endothelial cell proliferation, cell migration, and the survival of 48

POSTER ABSTRACTS

working on microbes of caves and other low‐ nutrient ecosystems. Since acquiring and installing the Roche/454 pyrosequencer the instrument has been employed to sequence 16 microbial genomes totaling more than 500 Mb. In addition, numerous transcriptome, phylogenomic and phylogeographical studies have been undertaken based on the capabilities of this instrument.

Examples of sequenced genomes include the ergot fungi (Claviceps species) responsible for episodic human poisoning and implicated in the Salem Witch Trials, and the apicomplexan Sarcocystis neurona, a distant relative of the malaria pathogen and a cause of equine neuropathy. Other projects involve transcriptome sequencing of plants, insects, and insect‐gut symbionts.

Keywords: ecology, evolution, genomics, infrastructure ___________________________________________

23. Clinical Mass Spectrometry to Quantify Therapeutic and Endogenous Cardenolides with Anti‐Cancer Properties SM Truscott*, DW Wilkey, B Bogdanov, ML Merchant, Valdes R Jr. University of Louisville

Digoxin is a plant‐derived cardenolide used to treat cardiac arrhythmias, yet several studies indicate that some cancer patients treated with digoxin respond more favorably to cancer therapies. Our lab has shown that the endogenous mammalian cardenolide, digoxin‐like immunoreactive factor (DLIF), can selectively kill cancer cells, but spares normal cells. Thus DLIFs may be novel functional indicators of the endogenous anti‐tumor response.

These endogenous compounds are very difficult to purify and are detected using anti‐digoxin antibodies which are inherently neither specific nor sufficiently sensitive for measuring DLIF in serum.

Mass spectrometry (MS) provides a reliable, sensitive, and specific alternative. The ultimate objective of this project is to develop a rapid and accurate clinical MS method for measuring endogenous DLIF concentrations in blood. This

genetic underpinnings governing the undertaking behaviors toward corpses from inter‐ and intra‐ species will be investigated using a brain chip customized from brain transcriptomes of three lower termite species including R. flavipes, R. virginicus, and Coptotermes formosanus. This study is a part of our efforts to gain a better understadning of the evolution of eusociality in termites using genes with social contents.

Keywords: undertaking behavior, colony hygiene, Reticulitermes flavipes, brain transcriptome, eusociality, termites ___________________________________________

22. Kentucky Initiative in Ecological Genomics Christopher L. Schardl*(1), Hazel Barton(2), Patrick Calie(3), Jerzy W. Jaromczyk(1), Arnold J. Stromberg(1), S. Randal Voss(1), Bruce A. Webb(1), Tianjing Ge(1), Jinze Liu(1), David H. McNear(1), David W. Weisrock(1), Ruriko Yoshida(1), Xuguo Zhou(1) (1)University of Kentucky, (2)Northern Kentucky University, (3)Eastern Kentucky University

The Kentucky Initiative in Ecological Genomics (KIEG) supports infrastructure and staff support for high‐throughput sequencing at the University of Kentucky Advanced Genetic Technologies Center (UK‐AGTC), as well as financial support for new faculty and their students working in the area of ecological genomics. This program has funded the purchase of a Roche/454 Titanium pyrosequencer and ancillary equipment, plus approximately $50,000 of computer hardware and $5,000 in software to handle data generated on the pyrosequencer, whole genome and whole transcriptome assemblies, a Chado database, and GBrowse sites for ongoing genomics projects. The grant supports two full‐time graduate research assistants per year, a bioinformatician and the AGTC senior facilities manager. Supported research projects at regional universities include those of Patrick Calie at Eastern Kentucky University, working on native plant phylogenetics, and Hazel Barton at Northern Kentucky University, 49

POSTER ABSTRACTS

approach to understand the impact of the flow ratio on the width of the sample stream. One of the main tasks is simulating the correlation between the diffusion coefficients, velocity ratio and the sample distribution which can be useful to help researchers to get the better signal. Others including cells moving is simulated with considering the hydrodynamic focusing affect. An hourglass‐ shaped conductive stream is also simulated to help the experiment scientists adjust the velocity ratio to meet the desirable data.

Keywords: Coulter counter, hydrodynamic focusing, concentration ___________________________________________

25. Identification of Parameters to Quantitatively Assess Leukocyte Mechanosensitivity Xiaoyan Zhang*, Dongying Zhan, Hainsworth Y. Shin Center for Biomedical Engineering, University of Kentucky

Fluid flow‐derived shear stresses deactivate leukocytes by minimizing their pseudopod activity and surface expression of adhesive CD18 integrins under physiological conditions. Impairment of theses responses has been linked to a chronic inflammatory state prevalent in cardiovascular diseases (e.g., hypercholesterolemia).

Fundamentally, such a link suggests that leukocyte mechanosensitivity is critical for circulatory homeostasis. Based on this, a goal of our lab is to identify potential measures of leukocyte shear sensitivity for use as indicators of the onset/progression of hypercholesterolemia‐related pathologies. For this purpose, we explored the use of shear‐induced pseudopod retraction and CD18 cleavage as potential parameters. Our results showed that, at the functional level, shear‐induced pseudopod retraction by human leukocytes diminished and eventually reversed after incubation with increasing concentrations of membrane cholesterol‐enhancing agents and highly correlated (R2=0.96; p<0.0001) with cholesterol‐dependent membrane fluidity. At the

abstract reports the initial stage of the project – the development of a clinically validated MS method to quantify digoxin as a surrogate for DLIF. With DLIF purification ongoing, we have utilized both a Fourier‐transform ion cyclotron resonance mass spectrometer (FTICR‐MS) and a triple stage quadrupole tandem mass spectrometer (TSQ) to begin development of the quantitative digoxin assay. Calibration of the instrument response was linear for both instruments (r2 > 0.99) and highly reproducible (CV <15% at the low end of the dynamic range). The TSQ was the more sensitive instrument with a lower limit of detection ~0.1 ng/mL. This work sets the stage for measurement of endogenous DLIF in serum using MS. Supported

by Kentucky Science & Engineering Foundation Grant #148‐502‐10‐263, NSF/EPSCoR Grant #EPS‐ 044749, and NIEHS P30ES014443.

Keywords: digoxin, DLIF, cancer, mass spectrometry ___________________________________________

24. Numerical Simulation for the Hydrodynamic Focusing Effect in the Microfluidic Coulter Counter Muheng Zhang*(1), Yongsheng Lian(1), and Cindy Harnett(2) (1)Department of Mechanical Engineering, and (2)Electrical and Computer Engineering, University of Louisville

Micro fluidic Coulter counter is an electrical impedance‐based device for counting and sizing particles and cells. When a non‐conductive cell passes through the electrical field, it causes a signal spike. The number and size of cells can be obtained by analyzing the signal. The quality of the signal is largely affected by the width of the sample conductive stream. The best signal usually is obtained when the width of the sample stream is comparable to the cell diameter. In a Coulter counter, hydrodynamic focusing technology can be used to control the sample stream width through adjusting the sheath and sample stream flow ratio.

The focus of this work is to use a numerical 50

POSTER ABSTRACTS

within the time frame of mobile signal generation and translocation to the distal tissues. Since most mutations affecting cuticle development also impair fatty acid (FA) and/or lipid biosynthesis, we studied a role for these in SAR. Our results show impaired biosynthesis of FAs or lipids do not contribute to SAR. we have uncovered several mutations that specifically alter cuticle without influencing FA or lipid biosynthesis and they were impaired in SAR. Besides SAR, most mutants with abnormal cuticle showed enhanced susceptibility to necrotrophic fungal pathogens and this phenotype did not correlate with cuticular permeability. The studies demonstrate an important role for cuticle in induced as well as basal defense responses.

Keywords: cuticle, systemic acquired resistance, Basal defense ___________________________________________

27. EDS1 and Salicylic Acid Act Redundantly to Regulate Oleic Acid‐Mediated Defense Signaling Shifeng Zhu*, Qing‐ming Gao,Rae‐Dong Jeong, Srivathsa C. Venugopal, Mihir K. Mandal, Ludmila Lapchyk, Aardra Kachroo, Pradeep Kachroo Department of Plant Pathology, University of Kentucky

Oleic acid (18:1) is one of the major monounsaturated fatty acids (FA) in plants and its biosynthesis is catalyzed by the SSI2 encoded soluble stearoyl‐acyl‐carrier‐protein‐desaturase (SACPD). We have previously shown that reduction in the 18:1 levels, via a mutation in ssi2 or silencing of SACPD genes, results in constitutive activation of plant defense pathways in Arabidopsis and soybean, respectively. More recently, we have provided evidence linking 18:1 levels with resistance (R) gene expression and pathogen resistance. Lowering the levels of 18:1, via genetic mutations in SSI2, or by exogenous application of glycerol, induces the expression of several R genes.

Genome‐wide analysis showed that at least 25 R genes (and R proteins) were upregulated in the ssi2 plants in a salicylic acid (SA)‐independent manner.

Detailed characterization showed that SA acts

molecular level, fluid shear exposure time‐ dependently downregulated the surface expression of CD18 by neutrophils, monocytes and lymphocytes; notably, shear‐induced reductions in cell‐surface CD18 were receptor subtype‐specific.

Together, these results provided evidence that leukocyte mechanosensitivity depends on cell membrane fluidity and cell type contingent on their differential expression and cleavage of CD18 subtypes. In this regard, the degree of pseudopod retraction and CD18 downregulation by leukocytes in response to shear flow may be used as indicators of leukocyte‐specific shear mechanosensitivity. As such, the results of our studies provided a basis for future efforts to develop micro‐scale flow devices for use as diagnostic tools that employ quantitative leukocyte mechanosensitivity indices as indicators of cardiovascular health status.

Keywords: fluid shear stress, pseudopod retraction, CD18 cleavage ___________________________________________

26. Cuticle Plays an Important Role in Basal as well as Induced Defense Against Bacterial and Fungal Pathogens Y. Xia, Q.M. Gao*, K. Yu, A. Kachroo, P. Kachroo Department of Plant Pathology,University of Kentucky

Systemic acquired resistance (SAR) is a phenomenon in plants that confers protective immunity in the distal tissues towards secondary infections by related or unrelated pathogens. SAR involves the generation of mobile signal (s) at the site of primary infection, which then translocates to, and activates defense responses in the distal tissues. Although several signals have been implicated to play a role in SAR, the signaling events leading to activation of SAR still remains unclear. Recently, we showed an intact cuticle is required for decoding of the mobile signal in the distal tissues. Genetic mutations leading to abnormal cuticle or physical damage of cuticle on the distal leaves compromised SAR. The requirement for intact cuticle was only relevant 51

POSTER ABSTRACTS

death occurred only upon AMF‐irradiation. This novel nano‐magnetic carrier has potential to be a non‐invasive and externally controlled drug delivery system for cancer therapeutics.

Keywords: doxorubicin, doxorubicin delivery, alternating magnetic field‐induced drug delivery, hyperthermia, magnetic nanoparticle, oximation, oxime ___________________________________________ 29. MG53 Mediated Muscle Membrane Repair Chuanxi Cai*(1), Xiaojun Liu(1), Lei Teng(1), Hiroshi Takeshima(2), Jianjie Ma(3) (1)Department of Medicine, Institute of Molecular Cardiology, University of Louisville, (2)Department of Biological Chemistry, Kyoto University Graduate School of Pharmaceutical Sciences, (3)Department of Physiology and Biophysics, UMDNJ‐Robert Wood John

Ischemic heart disease is the most common cause of death in most Western countries. Developing novel therapeutic approaches that can directly target the causes of cardiomyocyte death during Ischemia/reperfusion (IR) injury will have broad translational potential. One pathway with great potential as a therapeutic target in regenerative medicine is the process by which individual cells repair their plasma membrane following injury. We previously found that MG53 is a novel, muscle‐ specific member of the TRIM family of proteins (TRIM72), which contributes to the dynamic membrane repair process in skeletal muscle.

However, the role of MG53 in myocardial protection remains unknown. Recently, we found that the mg53‐/‐ hearts are vulnerable to ischemia‐ reperfusion injury and increased MG53 expression can protect cardiomyocytes from oxidative‐stress induced cell death. And the acute injury of the cell membrane leads to exposure of a signal to the extracellular space that can be detected by MG53, allowing recombinant MG53 to repair membrane damage when provided in the extracellular space.

Our data also showed that recombinant MG53 purified from E. coli retains efficient membrane repair function, supporting the therapeutic value of

redundantly with EDS1 (enhanced disease susceptibility 1) to regulate 18:1‐mediated signaling. Notably, EDS1 function is also redundant between two isoforms and either of these can function in 18:1 regulated pathway. Detailed molecular and biochemical characterization of 18:1 regulated pathway will be presented.

Keywords: salicylic acid, EDS1, oleic acid, defense signaling ___________________________________________

28. Externally Directed AMF‐Triggered Release of Doxorubicin from Magnetic Carriers Souvik Biswas*(1), Laura E. Gordon(2), Geoffrey J. Clark(2), Michael H. Nantz (1) (1)Department of Chemistry, University of Louisville, (2)School of Medicine, Brown Cancer Center, University of Louisville

Iron oxide nanoparticles (NPs) have attracted a great deal of attention recently as agents for nano‐ therapeutics. The magnetic properties as well as other inherent features, such as low cytotoxicity, ease of functionalization and colloidal stability, makes these NPs ideal for biomedical applications.

Importantly, magnetic NPs generate heat when induced with an alternating magnetic field (AMF) via magnetic oscillations of their magnetic moments. This unique property has been well studied and applied in hyperthermia treatment where heat generated (ca. 42‐45 ºC) kills tumor cells in the presence of healthy cells. Here we demonstrate an externally controlled AMF‐ triggered nano‐magnetic drug delivery system in which custom drug‐loaded iron oxide nanoparticles release cargo in response to the heat generated on AMF‐induction. We have designed a nano‐ magnetic delivery system for the anti‐cancer drug doxorubicin (Dox) by loading an oxime ether doxorubicin‐conjugate onto iron oxide nanoparticles nanoparticles. A drug release study shows that ~70% of the Dox conjugate is released when exposed to an AMF for 15 min. A cytoxocity study using MCF‐7 cells treated with the nanomagnetic Dox formulation revealed that cell 52

POSTER ABSTRACTS

Furthermore, GmFAD3‐silenced plants produced seeds that were significantly larger in size and weight. Our results thus show that the GmFAD3 genes modulate diverse biological processes including seed development and defense signaling in soybean. We have also used the BPMV vector for rapid evaluation of proteins with known antifungal or anti‐nematode activities.

Keywords: virus vectors, soybean, protein expression,disease resistance ___________________________________________

31. Progressive Rod Degeneration in Miniature Pig Model of Retinitis Pigmentosa Wei Wang, Juan P. Fernandez de Castro, Eric Vukmanic, Douglas Emery, Jennifer Noel, Maureen McCall, Paul DeMarco, Douglas C. Dean, Henry J. Kaplan* Department of Ophthalmology and Visual Sciences, University of Louisville

PURPOSE: We have developed a model of retinitis pigmentosa (RP) using somatic cell nuclear transfer with the most common rhodopsin mutation in autosomal dominant RP (Pro23His) in an inbred miniature pig. The aim of this study is to characterize the progression of retinal degeneration in the P23H pig retina during the period of maximum photoreceptor degeneration; thus, contributing useful data for exploiting this novel pig eye model and providing a biomedical model that is ideal for therapeutic interventions involving cell transplantation and other therapies.

METHODS: Pig eyes were examined and monitored using ophthalmoscopy, fundus photography, fluorescein angiography and OCT from postnatal day 1 (P1) to 18 months of age. Retinal degeneration was assessed by histology and immunocytochemistry of rod and cone photoreceptor markers. Photoreceptor cell apototosis was examined using TUNNEL staining.

RESULTS: Photoreceptor cell death was evident at P1, and OCT demonstrated marked retinal thinning at 21 months; H&E staining of retinal sections demonstrated that only one row of photoreceptors

targeting MG53 in heart injury and other human diseases. The results may provide novel insights into proof‐of‐principle studies to develop effective protein‐based therapies for cardiac repair in patients with cardiovascular diseases.

Keywords: MG53, membrane repair, heart failure, ischemia/reperfusion ___________________________________________

30. Use of a Virus‐Based Vector for Stable Protein Expression and Gene Function Studies in Soybean Said Ghabrial*, Suryadevar Rao, Ajay Singh, Mohamed El‐Habbak Department of Plant Pathology, University of Kentucky

Plant virus‐based vectors provide an attractive and cost effective means for stable protein expression and gene function studies in soybean. Soybean is the top oilseed crop in the world and presents an important multi‐billion dollar, source of high quality protein. There is critical need at present for tools that allow for rapid evaluation of new traits involving expression of beneficial proteins. In the present study, we used the bean pod mottle virus (BPMV)‐based vector to explore the expression of two important soybean defense‐related genes SCaM4 and GmFAD3. SCaM4 encodes a specific isoform of the soybean protein calmodulin.

Overexpression of SCaM4 in soybean resulted in increased resistance to the root and stem rot pathogen, Phytophthora sojae, the Alternaria leaf spot fungus, Alternaria tenuissima and the pod and stem blight fungus, Phomopsis longicolla. Silencing of SCaM4, on the other hand, resulted in enhanced susceptibility to these three pathogens.

Furthermore, the SCaM4‐overexpressing soybean plants exhibited increased tolerance to high salt conditions. In another set of experiments, silencing of three genes coding for microsomal isoforms of the omega‐3 fatty acid desaturase (GmFAD3) increased levels of the hormone jasmonic acid (JA) and JA‐ responsive defense genes as well as enhanced resistance to Phytophthora sojae.

53

POSTER ABSTRACTS

average angular motion of all gait cycles at each speed was determined for each level. The tri‐planar ranges of motion and the variability of motion were compared as a function of age. Older subjects had 31.7% larger (p=.036) frontal Cobb angles and up to 30.9% and 33.5% smaller (p=.005 and p=.001) ranges of spinal motion in the frontal and sagittal planes, respectively, compared to younger subjects. Variability of motion in the sagittal plane was up to 42.9% less in older subjects. Decreased ranges and variability of spinal motion observed in older subjects may imply that gait‐related loads are not as uniformly distributed across the vertebrae in the elderly. If greater stresses result from the abnormal motion, the likelihood of fatigue fracture may increase. Simple and inexpensive countermeasures to prevent fractures by restoring more normal spinal motion may be possible.

Keywords: spinal kinematics, vertebral fracture, aging, skin markers, gait‐related spinal motion ___________________________________________

33. Simple Modeling to Study Prediction and Prevention of Fragility Fractures of the Hip Michael J. Voor*, Robert L. Burden Jr. Orthopaedic Bioengineering Laboratory, University of Louisville

AIM: The objective of this project was to apply mechanical testing models and finite element analyses to determine the influence of bone quality, cortical thickness, and a novel implantable device on the fracture risk of the femoral neck loaded to simulate a fall to the side. METHODS: Mechanical testing of hip models and axisymmetric finite element analysis (FEA) simulated the compressive buckling fracture of the superolateral cortex of the femoral neck that often occurs in a fall to the side. In the FEA, the maximum von Mises stress in the femoral neck was determined for each model. RESULTS: The femoral neck “failed” when there was zero cortical thickness combined with low density cancellous bone and also when there was a thin (0.5 mm) cortex and no cancellous bone in the neck region. Both of these conditions were

remained in the outer nuclear layer at this time.

Immunostaining demonstrated a progressive loss of rod photoreceptors during the period between P1 and 18 months of age. And, by 21 months of age, cones comprised the single row of photoreceptors remaining. CONCLUSIONS: The P23H miniature pig displays progressive loss of rod photoreceptors mimicking what is observed in RP patients. Thus, these transgenic pigs represent a large animal model of rod photoreceptor loss which can be used in future studies of cell transplantation or other therapies for retinal repair.

Keywords: retinal degeneration, retinitis pigmentosa, pig model ___________________________________________

32. Spinal Posture and Gait‐Related Vertebral Body Motion in Normal Older and Normal Younger Female Subjects Shaun K. Stinton(1), David R. Mullineaux(5), William O. Shaffer(4), R. Carter Cassidy(5), David D. Pienkowski(1,3), Robert Shapiro*(1,2) (1)Center for Biomedical Engineering, University of Kentucky, (2)Department of Kinesiology and Health Promotion, University of Kentucky, (3) Department of Orthopaedic Surgery, University of Kentucky, (4) Northwest Iowa Bone, Joint and Sports, (5) Unive

Spontaneous vertebral fractures are a large and growing health care problem. Abnormal posture or gait‐related motion may induce altered spinal kinematics that in turn increase the likelihood of these fractures. The goal of this research was to quantify spinal posture and gait‐related spinal motion parameters in older and younger subjects to determine the effect of age. Static x‐rays and a 3D optical method for measuring spinal motion during gait were employed to quantify spinal postural and motion parameters in 12 older (age:58.4±5.1years) and 12 younger subjects (age: 26.3 ± 3.7 years). Vertebral motion around 3 axes was measured at 4 levels (T7,T10,T12,L2) by using noninvasive retroreflective markers during treadmill gait at 3 speeds (0.5,0.7,0.9m/s). The 54

POSTER ABSTRACTS

the concentration peak. The displacement between the two cells can be increased in horizontal direction but decreased in the vertical direction by the hydrodynamic focusing affect. An hourglass‐ shaped conductive stream is simulated and this is can be helpful for experiment scientists to adjust the velocity ratio to meet the desirable data.

Keywords: Coulter counter, hydrodynamic focusing, concentration ___________________________________________

35. Search for Earth‐Like Planets Outside Our Solar System Using Transit Timing Variations Karen Collins*, John Kielkopf Department of Physics and Astronomy, University of Louisville

The discovery of more than 500 planets orbiting stars other than the Sun (exoplanets) over the past 15 years has confirmed that the Sun is not unique among stars in hosting planets. However, this discovery is only a starting point in the quest to determine if life exists beyond our solar system.

Most of these planets have a mass similar to Jupiter in our solar system, but they orbit very near their host star (i.e. hot Jupiters). In this project, we study known hot Jupiter exoplanets using a technique called Transit Timing Variation (TTV), which is capable of detecting Earth‐mass planets in the same exoplanetary system. An important technique used to find and observe exoplanets depends on the small geometric chance that an exoplanet’s orbit passes directly through the line of sight from Earth to the exoplanet’s host star. As the planet crosses in front of (i.e. transits) its star each orbit, it blocks a small amount of the star’s light, causing it to appear to dim slightly. A time‐series of precision measurements of the apparent dimming using photometry yields a wealth of information about the exoplanet. One characteristic that can be measured is the precise time that a planet passes in front of its star during each orbit. If no other planets are in the system, the known exoplanet will pass in front of its star at precisely the same interval for each orbit. However, if a second (unknown)

protected from failure by the device. With 1.5 mm or greater cortex thickness, the risk of fracture was always less than 33%. CONCLUSIONS: Cortical wall thickness and cancellous bone distribution are much better predictors of femoral neck fracture risk than cancellous bone density in computational simulation of fragility hip fractures. A simple metallic implant device can decrease the risk of such fractures, particularly in the poorest quality bone.

Keywords: osteoporosis, fracture, hip, implant, bone ___________________________________________

34. Numerical Simulation for the Hydrodynamic Focusing Effect in the Microfluidic Coulter Counter Muheng Zhang*(1), Yongsheng Lian(1), Cindy Harnett(2) (1)University of Louisville Mechanical Department, (2)University of Louisville Electrical and Computer Engineering Department

Micro fluidic Coulter counter is an electrical impedance‐based device for counting and sizing particles and cells. When a non‐conductive cell passes through the electrical field, it causes a signal spike. The number and size of cells can be obtained by analyzing the signal. The quality of the signal is largely affected by the width of the sample conductive stream. The best signal usually is obtained when the width of the sample stream is comparable to the cell diameter. In a Coulter counter, hydrodynamic focusing technology can be used to control the sample stream width through adjusting the sheath and sample stream flow ratio.

The focus of this work is to use a numerical approach to understand the impact of the flow ratio on the width of the sample stream. The correlation between the sample distribution and the diffusion coefficient can be useful to help researchers to adjust the sample concentration, so does the ratio of the velocities between the sample stream and the sheath streams. An approximate function is given to calculate the vertical position of 55

POSTER ABSTRACTS

late‐term, and preterm. Muscle mass was estimated from measures of tongue thickness using ultrasonography. Muscle force produced by the infant tongue during nutritive sucking and nonnutritive sucking was measured using biomechanical and engineering methods to instrument bottle nipples and pacifiers.

Examination of muscle thickness suggests difference between infant groups; mean tongue thickness was greatest for full term infants.

Examination of force data suggests differences in tongue force and rhythm between full term and preterm infants for both nutritive and nonnutritive sucking. These techniques hold promise for measuring infant tongue muscle thickness and force. These pilot data must be interpreted cautiously but suggest differences in tongue muscle characteristics for healthy versus preterm infants.

Such measures may help to inform us regarding the impact of extended non oral feeding in special infant populations.

Keywords: infant, tongue, muscle mass, force ___________________________________________

37. Cigarette Smoke Extract Enhanced Ambient Ultrafine Particle‐Induced Oxidative Stress in Endothelial Cells Yiqun Mo(1), Rong Wan(1), Sufan Chien(2), David J. Tollerud(1), Qunwei Zhang*(1) (1)Department of Environmental and Occupational Health Sciences, (2)Department of Surgery, University of Louisville

Previous studies have shown that ambient ultrafine particles (UFPs) may pass from the lungs to the circulation because of their very small diameter, and induce lung oxidative stress with a resultant dysfunction of lung endothelial cells. A number of epidemiological studies have shown that cigarette smoke induces cardiovascular disease. However, no studies have addressed the potential combined effects of UFPs and cigarette smoke on vascular endothelial cells. We hypothesized that co‐ exposure to UFPs with cigarette smoke extract (CSE) may cause combined effects on activation of

exoplanet is orbiting the same star, the interval between transit times of the known exoplanet will vary slightly due to gravitational interactions between the two planets. These TTVs can be measured by observing multiple transits of an exoplanet and determining the difference in the observed and predicted regular interval transit times. Using orbital dynamics models, probable masses and orbital periods can then be determined for a perturbing exoplanet. When two planets are in mean‐motion resonant orbits, the TTV method is sensitive to even Earth‐mass exoplanets. In this work we discuss our early results, including TTV measurements for exoplanet WASP‐12b. We are conducting this research utilizing telescope facilities at Moore Observatory near Louisville, Kentucky and Mt. Kent Observatory near Toowoomba in Queensland, Australia.

Keywords: astronomy, planets, exoplanets, transit timing variations WASP‐12b ___________________________________________

HUMAN HEALTH AND DEVELOPMENT

36. Effects of Non‐Oral Feeding on Infant Tongue Muscle Mass and Force Gilson Capilouto(1), Tim Butterfield*(1), Tom Cunningham(2), Hari Challa(3), Eric Frederick*(1), Esther Dupont(1), Nirmala Desai(3) (1)University of Kentucky, (2)TC Motions, Inc., (3)UK Chandler Medical Center/KCH

Safe and efficient feeding is a critical milestone for infants in the Neonatal Intensive Care Unit (Pickler, 2004). The tongue is a driving force of the infant swallow (Wolf & Glass, 1992); understanding the impact of extended non‐oral feeding on infant tongue muscle mass would broaden the understanding of factors that contribute to infant feeding and swallowing problems. The aim of this study was to develop and test reliable, noninvasive procedures for measuring and interpreting tongue muscle thickness and force in infants. Three groups of infants were recruited; healthy full term, healthy 56

POSTER ABSTRACTS

Mechanisms of Orthostatic Intolerance M. Keith Sharp Department of Mechanical Engineering, University of Louisville

A large fraction of astronauts returning to earth suffer dizziness and other symptoms of orthostatic intolerance. While a wide range of factors may contribute to this problem, the loss of circulating blood due to capillary filtration is one of few that can explain the gradual decline of arterial pressure during stand tests. Over the past decade, we have used a computer model to investigate the relative importance of these hemodynamic parameters as contributors to orthostatic intolerance. In our most recent simulations, orthostatic tolerance times were compared to previous experiments combining head up tilt (HUT) and lower body negative pressure (LBNP) graded orthostatic stress, which provided hemodynamic data that allowed subject‐ specific modeling of capillary transport. The seven‐ compartment cardiovascular system model used measured heart rate, stroke volume, total peripheral resistance, mean arterial pressure and hematocrit data for twelve subjects. Simulations were controlled by decreasing the total blood volume at the measured rates of capillary filtration until cerebral pressure dropped below a threshold for consciousness. For an Wilcoxon alpha level of 0.05, there was no statistical difference in modeled times to syncope and actual times to presyncope.

Both arterial pressure and cardiac output were most sensitive to total blood volume and least sensitive to caudal compliance parameters. The feasibility of subject‐specific simulations of cardiovascular response to orthostatic stress was demonstrated, providing stronger evidence that capillary filtration is a prominent mechanism in causing orthostatic intolerance.

Keywords: computer modeling, biomechanical mechanisms, orthostatic intolerance ___________________________________________

39. Fluid Pressure Selectively Influences

endothelial cells and dysfunction of endothelium by oxidative stress through activation of NADPH oxidase. We determined the combined effects of UFPs with or without CSE on mouse pulmonary microvascular endothelial cells (MPMVEC) obtained from wild‐type mice and gp91phox knock‐out mice (gp91phox is one of the key components of NADPH oxidase, which is located in the cell membrane), respectively. Our results showed that exposure of MPMVEC from wide‐type mice to UFPs, CSE or UFPs with CSE, at a non‐toxic dose, induced reactive oxygen species (ROS) generation, increased phosphorylation of p38 and Erk1/2, and up‐regulation of early growth response ‐1 (Egr‐1) and IL‐6 expression. Furthermore, exposure of MPMVEC from wide‐type mice to UFPs with CSE caused significantly increased ROS generation compared to those exposed to UFPs or CSE alone.

Our results also showed that there were combined effects of increased phosphorylation of p38 and Erk1/2, upregulation of Egr‐1 and IL‐6 expression when MPMVEC from wide‐type mice were exposed to UFPs with CSE. However, exposure of MPMVEC from gp91phox knock‐out mice did not induce the above effects. UFPs‐ and/or CSE‐induced Egr‐1 mRNA upregulation was attenuated significantly when cells were pre‐treated with a p38 specific inhibitor, SB 203580, and Egr‐1 siRNA treatment abolished UFPs‐ and/or CSE‐induced overexpression of IL‐6. Our results suggest that UFPs, CSE, and UFPs with CSE caused the activation of NADPH oxidase, resulting in ROS generation that led to activation of MAPKs through induced phosphorylation of p38 and ERK1/2 MAPKs and upregulation of Egr‐1. Those effects may further result in endothelial dysfunction through production of cytokines such as IL‐6. Our results suggest that co‐exposure to UFPs and CSE causes combined injury to endothelial cells than exposure to UFPs or CSE along.

Keywords: ultrafine particles, cigarette smoke extract, reactive oxygen species, NADPH oxidase, gp91phox, MAPKs, Egr‐1, IL‐6. ___________________________________________ 38. Computer Modeling of Biomechanical 57

POSTER ABSTRACTS

___________________________________________

40. Noninvasive Scoring of Mouse Sleep and Behavior Farid Yaghouby(1), Elizabeth Salmon*(1), Kevin Donohue(2), Bruce O’Hara(3), Sridhar Sunderam*(1) (1)Center for Biomedical Engineering, (2)Department of Electrical and Computer Engineering, (3)Department of Biology, University of Kentucky

Sleep and wake states are poorly understand at a mechanistic and functional level. Identification of genes that contribute to normal and abnormal sleep‐wake behaviors would improve our understanding and suggest new pathways and approaches for the treatment of sleep disorders.

Many genes play a role in determining sleep patterns and circadian rhythms. Genetic approaches such as mutagenesis, quantitative trait locus analysis and knockout mice can help identify these genes and their respective roles. The downside is that screening for genetic factors affecting sleep requires expensive and labor‐ intensive animal experimentation with EEG/EMG analysis, not just simple actigraphy (i.e., activity monitoring). This severely limits the scale of behavioral experimentation. We have developed a noninvasive system for phenotyping sleep in mice based on the signal generated by a pressure‐ sensitive piezoelectric platform. This “piezo" system can already discriminate sleep from wake and track changes in breathing when the animal is relatively inactive. Preliminary observations indicate that pressure changes associated with respiration may have signatures characteristic of different stages of sleep as well. In this study, we demonstrate that features of the piezo signal that reflect breathing regularity and motion can be used to distinguish states that bear a strong statistical resemblance to REM and non‐REM stages of sleep as well as quiet and active wakefulness. The next step is to correlate these states with EEG‐scored states of vigilance. Successful noninvasive scoring of sleep and behavior will open up new avenues for

Endothelial Cell‐Related Tubulogenic Activity Hainsworth Shin*, Ryan Underwood, Xingjian Lei Center for Biomedical Engineering, University of Kentucky

The United Network for Organ Sharing reported in 2010 that >100,000 patients (including ~700 in Kentucky) were on waiting lists for organ transplants. Limited availability of donor material points to a critical need for strategies to engineer synthetic tissues. A significant barrier to their success is inadequate transport of nutrients and gases to, and waste away from, cells deep within the constructs. Generation of microvessels by endothelial cells (EC) in engineered constructs is, therefore, essential for facilitating tissue survival by promoting in‐vitro formation of microvascular networks, preimplantation, that integrate with host microvasculature and mimic the in‐vivo transport scheme, postimplantation. Previously, we reported that pressure stimulates EC proliferation involving release of angiogenic molecule, vascular endothelial growth factor (VEGF)‐C. Based on this, we hypothesized that fluid pressure is a selective modulator of tubulogenesis that may be used to enhance microvascularization of engineered tissues. To address this, we used a custom‐made pressure system to expose two‐ or three‐ dimensional cultures of EC to static pressures of 0 (controls), 20, or 40 mmHg (representative of in‐ vivo microvascular pressures). Compared to controls, two‐dimensional EC cultures exposed to 20, but not 40, mmHg for 3 days exhibited increases in cell densities that depended on VEGFR3, a receptor for VEGF‐C. Moreover, preliminary results showed that EC on microbeads suspended in three‐dimensional collagen gels under 20 mmHg displayed increased numbers of multicellular tube‐like sprouts. Our results suggest that pressure influences EC tubulogenesis. These findings serve as a first step towards identifying mechanobiological conditions that promote vascularization of engineered tissues.

Keywords: hydrostatic pressure, endothelial, tubulogenesis 58

POSTER ABSTRACTS

detection is feasible, but refinement is ongoing to optimize the SDA’s sensitivity and specificity.

Future work will involve correlation of seizure yield with tissue damage 72h post‐HI, with the goal of assessing long‐term outcome for neonates with HI‐ induced seizures.

Keywords: hypoxia, ischemia, EEG, seizure detection, neonatal, stroke ___________________________________________

high throughput analysis of sleep phenotypes and alleviate the need for EEG measurements.

Keywords: mouse, sleep, wake, REM, non‐REM, genetic screening ___________________________________________

41. Automated Detection and Characterization of Hypoxia‐Ischemia Induced Seizures in Neonatal Rats Elizabeth Salmon(1), Mathew Cuaycong(2), Susan J. Vannucci(2), Sridhar Sunderam* (1) (1)Center for Biomedical Engineering, University of Kentucky, (2)Cornell‐Weill Medical College

Neonatal seizures most commonly occur as a consequence of hypoxia‐ischemia (HI). Treatment of this phenomenon remains controversial, owing to the difficulty of correctly identifying seizures, which may consist of abnormal EEG with or without behavior, and sometimes seizure‐like behavior without EEG; these are labeled as clinical, electrographic, and behavioral seizures, respectively. We have used unilateral carotid ligation and hypoxia in neonatal rats as a model of hypoxic‐ischemic encephalopathy (HIE), and simultaneously recorded EEG, EMG, and video to document the experimental seizure yield during and following HI. An objective tool for quantifying seizure outcome would help assess the effect of different experimental conditions and interventions. The goal was to develop an automated seizure detection algorithm (SDA), specifically for this neonatal model of HIE, that can identify clinical, electrographic, and behavioral seizures from their EEG and EMG patterns. We have designed a prototype SDA that filters EEG and EMG to correct for background variation and emphasize episodes of high amplitude spiking activity; a novel aspect is the use of EMG to detect behavioral correlates of seizures. Seizure activity is detected when the processed signals exceed a user‐ selected threshold. The optimal threshold is determined through a receiver operating characteristic analysis, using visually scored events as ground truth. The results suggest that accurate

ENVIRONMENTAL AND ENERGY TECHNOLOGIES

42. Quartz Crystal Microbalance Investigation of Cellulase Binding, Activity and Inhibition on Model Cellulose Films Stephen E. Rankin*(1), Hsin‐Fen Li(1), Ravinder Garlapalli(1), Barbara L. Knutson(1), and Sue E. Nokes(2) (1)Chemical and Materials Engineering Department, University of Kentucky, (2)Biosystems and Agricultural Engineering Department, University of Kentucky

Soluble sugars produced from the hydrolysis of cellulose are promising feedstocks for production of fuels and commodity chemicals from renewable plant‐based resources. The recalcitrance of cellulose to degradation is well documented and attributed to multiple sources, including high cellulose crystallinity and the heterogeneity of biomass (dependent on pretreatment and presence of lignin). Cellulase is a cellulytic enzyme that possesses a catalytic domain capable of hydrolyzing the beta‐1,4‐glycosidic bonds in cellulose. However, during biomass conversion to soluble sugars, its hydrolytic efficiency is limited by nonproductive binding to hydrophobic components or inhibition by hydrolysis products. To study these factors, the changes in mass and surface properties of model cellulose thin films are measured using a Quartz Crystal Microbalance with Dissipation (QCM‐D). The cellulose thin films are synthesized by thermochemically dissolution followed by coating onto a quartz crystal resonator. The mass 59

POSTER ABSTRACTS

investigate the reduction of photovoltage by experimentally populating the excitonic states of electron accepting material: PCBM. Low power Xenon white light source is used for photobleaching experiments. In addition, capacitive photocurrent spectroscopy technique from white light source is described to show the huge charge dissociation from the exciton of PCBM with the main absorbance of organic semiconductor. In the current study, we suggest that filtering out the energy in white light, responsible for long‐lived excitonic state of PCBM, will enhance the AC photovoltage. Ultimately this will lead to enhance the stability and the efficiency of the organic solar cell.

Keywords: photobleaching, photovoltage, organic solar cells ___________________________________________

44. Characterization and Activity of Mesoporous Titanosilicate Ccatalysts with Isolated Titanium Sites Generated by Surfactant Complexation Janet C. Mohandas*, Suvid Joshi, Stephen E. Rankin Department of Chemical and Materials Engineering, University of Kentucky

Mesoporous titanosilicates with a homogenous distribution of tetra‐coordinated Ti sites prepared by combined templating using a sugar surfactant (dodecyl maltoside) and a cationic surfactant (cetyltrimethylammonium bromide) are characterized to determine the presence and activity of isolated tetra‐coordinated Ti sites. The primary characterization is performed using a model catalytic epoxidation reaction of styrene with aqueous peroxide. Surface acidity estimation is carried out by temperature‐controlled in situ diffuse reflectance infrared spectroscopy (DRIFTS) studies of ammonia adsorption, combined with UV‐ visible absorption techniques to quantify the total acidity of the materials. Selectivity and activity of the reaction towards styrene oxide are enhanced by using catalytic systems with controlled surface acidities. A rational explanation for the correlation

of the spin‐coated cellulose film is determined by the change in the resonance frequency, and the cellulose surface coverage is observed by atomic force microscopy (AFM). Cellulase adsorption, activity, and inhibition on model cellulose thin films as are measured directly as changes to the piezoelectric properties of the cellulose thin films

by QCM‐D. Here, we will report observations of (1) inhibition by cellobiose of cellulase derived from T. reesei, (2) the effects of bound inhibited enzyme on reducing subsequent cellulose hydrolysis, and (3) evidence that excessive enzyme coverage decreases activity, leading to an optimal enzyme concentration for sacharification. Plans to investigate effects of surface chemistry on cellulase binding will be discussed.

Keywords: biofuels, biomass, cellulose, saccharification, hydrolysis ___________________________________________

43. Use of Photobleaching Technique to Understand the Effect of Photovoltage on the Stability and Efficiency of Organic Solar Cells Buddika K. Abeyweera*, Hemant Shah, Bruce W. Alphenaar Department of Electrical and Computer Engineering

Due to rising fuel costs, solar cells have recently gained much attention as a possible clean alternative energy source. Organic polymer solar cells are of particular interest because of their relatively low manufacturing cost and flexibility.

Here, we describe a straightforward and low cost preparation technique to reproduce bulk heterojunction organic polymer solar cells with high yield using poly[2‐methoxy‐5‐(3,7‐ dimethyloctyloxy)]‐1,4‐phenylenevinylene (MDMO‐PPV) and [6,6]‐phenyl‐C61‐butyric acid methyl ester (PCBM) with the active area of 0.25cm2. Since the efficiency of these solar cells is low compared to conventional silicon solar cells, a novel approach is needed to enhance efficiency of Photovoltaics. In this project, we used photobleaching technique of organic solar cells to 60

POSTER ABSTRACTS

Molybdenum Oxide wire arrays grown on Silicon, quartz substrates showed that absorption was greater at angular incidence than at normal incidence of light. Ultimate objective of the project is to study synthesis and optical characterization of vertical arrays of Indium Nitride nanowires.

Keywords: light absorption, vertical nanowire arrays ___________________________________________

46. Titania/Bucky Paper Composites for Photocatalytic Dye Degradation and Photoelectrochemical Water Splitting Navaladian Subramanian, Qing Liu Wu, Xin Su, Bruce J. Hinds, Stephen E. Rankin Department of Chemical and Materials Engineering, University of Kentucky

The titania/carbon nanotube (CNT) composite system has been shown in several recent studies [reviewed by K. Woan et al., Adv. Mater. 2009, 21, 2233] to have high photoconversion activity because the CNTs facilitate photoinduced charge separation and limit recombination by transporting electrons away from the carrier generation site. In the current work, titania/bucky paper (self‐ supporting films of multiwalled CNTs) composites were fabricated by the sol‐gel method with a surfactant (Pluronic‐123) additive, or by dip‐coating buck paper with commercial TiO2 (Degussa P25) powder. The composites are characterized by x‐ray diffraction, N2 adsorption‐desorption isotherms, thermogravimetric analysis, UV‐Visible diffuse reflectance spectroscopy, and electron microscopy.

A uniform coating of anatase titania on bucky paper (with 44 % TiO2 in the composite) has been achieved by sol‐gel coating. The photoconversion efficiency of the composites is determined by photocatalytic degradation of methylene blue and photoelectrochemical water splitting in KOH solution under UV light. The results reveal a positive role of CNT in the photoconversion efficiency of the composites, most notably for the P25/buckypaper, which shows a photoconversion efficiency of 7.3% for hydrogen generation by water

of acidity of the corresponding catalysts including the nature and strength of the acidic sites with the observed activities is proposed. The results are compared with the TS‐1 zeolite, the state of the art catalyst for epoxidation reactions. Based on similarities in acidity and epoxidation activity, the existence of isolated Ti sites in the mesoporous catalysts has been proved. The extent of Ti incorporated in each sample is estimated using inductively coupled plasma–optical emission spectroscopy (ICP‐OES), which establishes increased Ti (IV) site incorporation in the mesoporous titanosilicates in comparison to TS‐1.

Mesoporous titanosilicate containing 1 mol% Ti (per metal) has approximately twice the activity per Ti as TS‐1. However, mesoporous titanosilicates with higher Ti content exhibit less activity per site, which may be due to a combination of decreasing surface area and increasing acidity.

Keywords: mesoporous titanosilicates, isolated Ti content, acidity, epoxidation catalysis ___________________________________________

45. Fundamental Studies of Light Absorption in Vertical Nanowire Arrays Sowmya Kolli*(1), Mahendra K Sunkara(2), Bruce W Alphenaar(1) (1)Department of Electrical Engineering, (2)Conn Center for Renewable Energy Research

In this project, we are investigating the light absorption within vertical nanowire arrays as a function of density, size and arrangement of nanowires compared to thin films. Recent studies showed that randomly ordered vertical nanowire arrays can absorb light efficiently compared to ordered arrays. Specifically, this was demonstrated with silicon wire arrays with enhanced near‐infrared to exceed the ray‐optics light‐trapping absorption limit for an equivalent volume of randomly textured planar Si, over a broad range of incidence angles. In this project, the initial measurements were performed using Molybdenum Oxide nanowire arrays. The absorption measurements at different angles of incidence were measured for 61

POSTER ABSTRACTS

partly specified motion. The basic idea behind this method is to solve for the open‐loop control input from the membrane‐actuator model that achieves the approximate desired shape. The open‐loop control is then augmented by a feedback loop that accounts for uncertainties due to modeling errors and external vibration disturbances. This proposed controller is tested through numerical simulations.

Analytical results will demonstrate the effectiveness and feasibility of the proposed controller.

Keywords: shape control, vibration control, membrane structures, servo‐constraints ___________________________________________

48. Kentucky Institute for Aerospace Education: Creating the Pipeline to Further Student STEM Opportunities Tim Smith* Kentucky Institute for Aerospace Education and Frankfort High School Aviation Academy

The Kentucky Institute for Aerospace Education (KIAE) is a 501(c)(3) organization that supports a STEM network of 12 high schools in Kentucky.

Schools in the KIAE network have been provided with an aerospace

Keywords: STEM, aviation, aerospace, engineering, flight, aircraft maintenance ___________________________________________

49. Autonomous Robot Design Competition Aleck W. Leedy Department of Engineering and Physics, Murray State

The purpose of this poster is to highlight the autonomous robot that was designed by the Murray State University Hardware (Robot) Team that competed in the IEEE SoutheastCon 2011 Student Hardware Competition April 2, 2011 in Nashville, TN. The theme of the 2011 competition was natural disasters. The focus was the use of autonomous robots to safely evaluate the situation,

splitting. The uniform coatings of TiO2 on buckypaper show that the texture of the titania (film vs. particle) plays a major role in photoconversion efficiency, and that it may be desirable to have some fraction of the CNTs exposed to aid in reactant adsorption and photocatalytic reactant generation.

Keywords: titania, carbon nanotubes CNT, bucky paper, sol‐gel, photoelectrochemical, water‐ splitting, hydrogen generation, photocatalysis, methylene blue degradation, energy conversion ___________________________________________

47. Shape and Vibration Control of Membrane Structures under Servo‐Constraints T. Michael Seigler and Amir. H. Ghasemi* Department of Mechanical Engineering, University of Kentucky

The objective of this research is to develop a control approach for the active shaping of large membrane structures using active materials.

Membrane mirrors are thin, flexible optical surfaces for satellite lenses that are lightweight and can be stored compactly. These types of mirrors are expected to enhance inflatable space technology by providing quality optical imaging while reducing current weight and storage requirements.

Membrane mirrors, however, require active surface control for proper imaging and are subject to various disturbances (including large thermal gradients and internally induced excitation) that can lead to degraded performance. Active materials, such as piezoceramics, have been proposed as a means of providing disturbance rejection via distributed actuation; the idea is to attach a number of actuators along the outer rim of the optic and actively control them to produce a desired motion. However, unlike typical piezoelectrically actuated structures, due to the properties of the membrane, the introduction of the piezoceramic significantly alters the dynamic behavior of the membrane structure. Here we propose a novel method of simultaneous shape and vibration control based on the dynamical theory of 62

POSTER ABSTRACTS

In this structure, one of the hydrogen atoms in the water molecule forms a strong hydrogen bond with an oxygen atom of the superoxide radical. The dissociation energy of the complex and the length of the hydrogen bond are estimated as 7540 cm‐1 and 1.7 angstroms, respectively. The outcomes of our study will be presented and compared to results of the previous studies.

Keywords: computation, preferential, hydrogen boding, complex ___________________________________________

51. Ionic Hydrogen Bonding in the Superoxide‐HF Radical Complex Ychen Zhang and Wafaa Fawzy* Department of Chemistry, Murray State University

The superoxide radical is one of the most important anions that play a major role in chemistry in the atmosphere and in biological systems. However, there have been few investigations on the nature of intermolecular interactions between the superoxide radical and other closed‐shell molecules in the gas phase. It has been shown that characterization of the potential energy surface (PES) of binary gaseous complexes is essential for understanding intermolecular interactions between entities of the complex as well as dynamics of chemical reactions in which the binary complex present a minimum either at the entrance or at the exit channel of the PES of the reaction.

Furthermore, determination of the PES of binary gaseous complex presents the first initial step toward understanding intermolecular interactions in the condensed phase. In this work, we carry out high level correlated ab initio study on the intermolecular PES of the superoxide—HF radical complex. This binary complex presents a prototype for an ion‐dipole type of intermolecular interactions.

Keywords: ionic, superoxide radical, hydrogen bonding, computation ___________________________________________

and relay vital information to emergency response teams. The objective of the competition was to locate the victims trapped in a building, determine their status, sense hazards, and report this information to the emergency responders. The Murray State team built a completely autonomous robot that is capable of locating victims, sensing hazards, avoiding obstacles, and recording its exact position at all times. The 2011 IEEE SoutheastCon Hardware Competition aligned well with NASA's Exploration Systems Mission Directorate (ESMD) that manages the development of capabilities of robotic exploration. The design of the robot required the Murray State team members to have a background / expertise in the following areas: electrical engineering, mechanical engineering, and computer science. The team members were required to have knowledge of electromagnetics, sensors, circuit building, computer programming, modeling and simulation software packages, and troubleshooting. Presented in this poster are the details of the robot system design that includes a system block diagram, circuit diagrams, graphical analysis, and a list of the major components of the system.

Keywords: autonomous, robot, sensors ___________________________________________

50. Preferential Hydrogen Bonding in the Superoxide‐Water Radical Complex Ziyou Tang and Wafaa Fawzy* Department of Chemistry, Murray State University

Previous computational investigations on the ground electronic state of the superoxide‐water complex showed that there are two local minima of C2v and Cs symmetries. On the other hand, a photofragmentation experimental study identified a minimum energy structure of Cs symmetry with a single hydrogen bond. We explored the potential energy surface of the superoxide‐water complex using the CCSD(T) level of theory with the aug‐cc‐ pVDZ basis set. Our preliminary results show two equivalent minimum energy structures that correspond to a planar geometry of Cs symmetry.

63

POSTER ABSTRACTS

a minimum energy structure of Cs symmetry with a single hydrogen bond. We explored the potential energy surface of the superoxide‐water complex using the CCSD(T) level of theory with the aug‐cc‐ pVDZ basis set. Our preliminary results show two equivalent minimum energy structures that correspond to a planar geometry of Cs symmetry.

In this structure, one of the hydrogen atoms in the water molecule forms a strong hydrogen bond with an oxygen atom of the superoxide radical. The dissociation energy of the complex and the length of the hydrogen bond are estimated as 7540 cm‐1 and 1.7 angstroms, respectively. The outcomes of our study will be presented and compared to results of the previous studies.

Keywords: computation, preferential, hydrogen bonding, complex ___________________________________________

54. Ionic Hydrogen Bonding in the Superoxide‐ HF Radical Complex Yuchen Zhang* and Wafaa Fawzy Department of Chemistry, Murray State University

The superoxide radical is one of the most important anions that play a major role in chemistry in the atmosphere and in biological systems. However, there have been few investigations on the nature of intermolecular interactions between the superoxide radical and other closed‐shell molecules in the gas phase. It has been shown that characterization of the potential energy surface (PES) of binary gaseous complexes is essential for understanding intermolecular interactions between entities of the complex as well as dynamics of chemical reactions in which the binary complex present a minimum either at the entrance or at the exit channel of the PES of the reaction.

Furthermore, determination of the PES of binary gaseous complex presents the first initial step toward understanding intermolecular interactions in the condensed phase. In this work, we carry out high level correlated ab initio study on the intermolecular PES of the superoxide—HF radical complex. This binary complex presents a prototype

52. Low‐Cost Conductivity Sensor with Data Logging T. M. Lucas*, C.K. Harnett Department of Electrical and Computer Engineering, University of Louisville

A microcontroller‐based sensor was developed to record water presence and conductivity for the Virtual Observatory and Ecological Informatics System (VOEIS) project. Integrated data logging and low power requirements make this device well‐ suited for data collection in remote locations around Kentucky. The conductivity information collected can give insight into pollution levels over time in natural water sources. The time‐stamped water presence can be used to record flooding patterns in an area, which is valuable for planning agricultural and commercial development.

The recorded measurements are calculated based on the inverse relationship between conductivity and resistivity. Electrodes are exposed to the environment to determine the resistance of the medium surrounding the sensor. A simple circuit provides analog input to an Arduino microcontroller for further processing. Calibration is performed by using KCL solutions with known concentrations to adjust for electrode spacing. The fitted conversion parameters are used by the Arduino to calculate the conductivity. Time‐ stamped measurements are taken periodically.

Data is recorded to a microSD card by the open source data logger.

Keywords: conductivity, VOEIS, environmental ___________________________________________

53. Preferential Hydrogen Bonding in the Superoxide‐Water Radical Complex Ziyou Tang* and Wafaa Fawzy Department of Chemistry, Murray State University

Previous computational investigations on the ground electronic state of the superoxide‐water complex showed that there are two local minima of C2v and Cs symmetries. On the other hand, a photofragmentation experimental study identified 64

POSTER ABSTRACTS

single household power demand became a desirable and feasible approach due to advances in computing infrastructure and capabilities. We have examined some of the explanatory variables and models used to predict aggregate demand at the daily and hourly levels, and apply them to a single household setting. We demonstrate our predictive methods using the Glasgow Electric Plant Board household power data in conjunction with Kentucky Mesonet and National Weather Service temperature data.

Keywords: aggregate power demand, single‐ household prediction, weather data ___________________________________________

57. Predictive Models for Pollutant Source Identification Using DNA Biomarkers and PCR Readings Kevin Andrew(1), Rick Fowler(2), Jonathan Quiton*(3,4) and Claire Rinehart(3,5) (1)Gatton Academy of Mathematics and Science in Kentucky, (2)Waters Laboratory, (3)Bioinformatics and Information Science Center, (4)Department of Mathematics and Computer Science, (5)Department of Biology, Western Kentucky University

In this poster, we present three predictive models for pollutant sourcei dentification. These models use two sets of data: one is the 16S rDNA sequence data from which we derive the fragment sizes and the other is from the quantitative real‐time PCR. We used the rDNA database to derive our coefficients for our models, and then use the PCR readings data as inputs to finding pollutant source probabilities. If one can mark fragment sizes from PCR outputs, then a multinomial logistic regression or a tree‐based (decision tree) regression model can be used. Otherwise, we present a Bayesian approach where the client is required to enter his prior probabilities and the expert to interpret the PCR readings and identify regions for the fragment size. Our initial analysis helped us identify seven out of 16 possible enzymes having some discriminatory power. This set of seven enzymes

for ion‐dipole type of intermolecular interactions.

Keywords: ionic, superoxide radical, hydrogen bonding, computation ___________________________________________

55. Dynamic Data Extraction, Data Visualization and Customized Statistical Analysis with Application to the Kentucky Mesonet Data Anoop Rao Paidipally*(1), Jonathan Quiton(1), Stuart Foster(2) and Guangming Xing(1) (1)Department of Mathematics and Computer Science, Western Kentucky University, (2)Geography and Geology and the Kentucky Climate Center, Western Kentucky University

There is a need to integrate large‐scale database, high‐performance computing engines and geographical information system technologies (GIS) into a user‐friendly web interface as a platform for data visualization and customized statistical analysis. In this poster, we present some concepts and design ideas regarding dynamic data storage and extraction and its link to open‐source computing and mapping technologies. Finally, we would like to demonstrate our progress using the Kentucky Mesonet Data.

Keywords: large‐scale database, high‐performance computing, geographical information system, web‐ interface, Kentucky Mesonet ___________________________________________

56. Some Results in Modeling Single Household Daily Power Demand Craig Dickson*(1), Jonathan Quiton(1), William Ray(2), Stuart Foster(3) (1)Department of Mathematics and Computer Science, Western Kentucky University, (2)Glasgow Electric Plant Board, (3)Department of Geography and Geology and the Kentucky Climate Center

In the past, modeling aggregate power demand had been the more practical way to approach the problem of forecasting daily electricity demand for a region. It was not until recently that modeling 65

POSTER ABSTRACTS

investigate the link between the Klebanoff modes in a transitional boundary layer and the low wavenumber components of the free stream turbulence spectrum.

Keywords: fluid mechanics measurements, turbulence, bypass transition, boundary layers ___________________________________________

serves as our final set of predictors to use all our models. Current and future work are also discussed.

Keywords: pollutant source identification, rDNA sequence, preditive models, decision tree, Bayesian probabilities ___________________________________________

58. Investigation of the Relationship Between Freestream Turbulence and Klebenoff Modes Mark A. Miller*, Sean C. C. Bailey Department of Mechanical Engineering, University of Kentucky

Delaying the transition from laminar flow to turbulent flow in a boundary layer has many advantages for aerospace systems, the principal one being a significant reduction in wall shear stress and thereby skin friction drag. Traditionally, the study of laminar‐turbulent transition has focused on the boundary layers forming along a nominally zero pressure gradient flat plat immersed in a disturbance‐free flow. In such conditions, the transition process has been well understood and its initiation can be described using the linearized, unsteady, Navier‐Stokes equations. In many engineering systems, the freestream is turbulent and therefore not disturbance free. Instead of following this well understood process, the boundary layer undergoes bypass transition.

During bypass transition, laminar‐turbulent transition occurs much earlier and the actual transition to turbulence is often preceded by the appearance of streamwise streaks of low momentum fluid within the boundary layer associated with spanwise distortion of the boundary layer thickness. Commonly referred to as ``Klebenoff modes'', these structures are long in the streamwise direction and narrow in the spanwise direction (with a width on the order of the boundary layer thickness). The interrelationship between the low wavenumber motions of the freestream turbulence and the formation of the Klebenoff modes is the focus of the proposed research project. We will use simultaneous particle image velocimetry and hot‐wire anemometry to

INFORMATION TECHNOLOGY AND COMMUNICATIONS

59. Ensemble Hidden Markov Model Classifiers for Detecting Explosive Devices Hichem Frigui*, Anis Hamdi CECS, University of Louisville

The performance of automated algorithms for buried mine and IED detection are strongly dependent upon a variety of factors that are correlated with device types, burial depths, and geographical and environmental conditions. It is typically the case that one sensor (or one feature) may perform well in one context and not so well in another context. The goal of the proposed research is to develop autonomous, robust, and efficient Hidden Markov Models (HMM) for detecting buried explosive objects, such as land mines and IEDs. Our approach strives to identify the different contexts, build and adapt models for each context, and develop fusion algorithms that can take advantage of the stronger sensors/ features for a given context without suffering from the effects of weaker sensors/features in the same context. The context identification and characterization would allow the algorithm to perform detection quickly and accurately in the presence of rapidly changing geographical and environmental conditions.

Keywords: landmine detection, ensemble HMM, model fusion ___________________________________________

60. Multiple Air Robotics Indoor Testbed (MARIT) Yinan Cui*, Tamer Inanc ECE, University of Louisville 66

POSTER ABSTRACTS

portion of the project has two phases and will be the main focus of this project. Phase 1: Navigation through the CVIP Lab and Verbal Description of the lab’s Demo’s: In this phase the robot will navigate its way to each demo point in the CVIP Lab, instruction the audience to follow him. The robot will then describe each demo and outline the important facets of each demo. The Student will design algorithms to employ the camera, sonar, and Laser scanner sensors to allow the robot to move safely through the lab environment as it gives the tour. Phase 2: Wireless Interface to Computers Controlling Each Demo: In this Phase the robot will be equipped with wireless remotes to activate demo’s, select proper demo programs, and run the entire tour without user intervention. Finally the student will help assist Graduate Students with the porting of our previous NASA applications as time allows in the coming year.

Keywords: autonmous robotics, player stage ___________________________________________

62. Earth‐Based Calibration of the S‐Band Synthetic Aperture Radar Onboard NASA’s Lunar Reconnaissance Orbiter Benjamin K. Malphrus*(1), Jeff Kruth(1), Michael Combs(1), Robert Kroll(1), Caleb Grimes(1), Ben Cahall(1), Ron Schulze(2), Darryl Royster(2), Scott (1)Morehead State University Space Science Center, (2)Johns Hopkins University Applied Physics Laboratory

The Lunar Reconnaissance Orbiter (LRO) is a NASA Robotic Program mission whose intent is to create a comprehensive atlas of the Moon’s features and resources. Among 6 science experiments on LRO is the Miniature Radio Frequency Technology Demonstration (Mini‐RF), an advanced synthetic aperture radar that operates in both the X and S bands of the radio spectrum. It is used to image the polar regions and search for water ice. The mini‐RF baseline modes include: two frequencies—S‐band (13 cm) and X‐band (4 cm); two resolutions— baseline (150 m/75‐m pixels) and zoom (15 m/7.5‐m pixels); and dual‐polarization. In 2010 NASA, Johns

An indoor testbed for controlling unmanned aerial vehicles (UAVs), Multiple Air Robotics Indoor Testbed (MARIT), is introduced. MARIT was established in Autonomous Robotics and Control Systems Lab (ARCS) at University of Louisville. It is instrumental to capture the 6 DOF (degree of freedom) dynamic position information of the small air robots fast and accurately in the 3D test domain. MARIT consists of 6 high‐resolution digital cameras (Vicon motion capture system) with superior frame rates (120 frames per second), quadrotors (Dranganflyers) with reflective markers, and a workstation PC. It uses captured data (including the translation axis values and axis rotation values of the robots) to form a closed‐loop control system, which provides accurate control of the robots within the testbed environment. Based on the software development kit provided by Vicon (Real‐Time SDK), the user can develop his or her own controller applications for various flight missions. This testbed can be further used to study autonomous systems in which multiple agents cooperate with each other to perform assigned tasks.

Keywords: UAV, trajectory generation, control ___________________________________________

61. Autonomously Robotic Tour Guide Luke Spicer, Ali Mahmoud*, Mike Miller, Aly Farag Computer Vision and Image Processing Lab, Electrical and Computer Engineering, University of Louisville

The first part of this work is completing the hardware and software upgrades on the ATRV robot and ATRV‐mini robot started this past year.

The hardware portion of this task consists of installing new motherboards, memory, powers supplies and communication interfaces. The software portion of this project consists of installing Linux drivers, the Linux OS, Uploading Player Stage and debug/ testing all interfaces. The next task is writing programs to enable the ATRV‐mini to give a guided tour of the CVIP lab. This guided tour 67

POSTER ABSTRACTS

of blazars and determine if these variations correlate with other properties of the blazars. To illustrate this work, we present an analysis of two blazars, 1ES 2344+514 and 0235+164. Initial results will be presented and discussed.

Keywords: X‐ray spectra, blazars, Chandra X‐ray Observatory ___________________________________________

64. Thomas More Telescopes in the Classroom Wes Ryle* Thomas More College

Providing middle school and high school educators with explicit and detailed student projects in the STEM disciplines is an efficient method for increasing student interest at a young age. The ideal STEM projects involve hands‐on student activities as well as a means for cooperation and feedback from the broader educational community. This proposal describes a two day instructor workshop in astronomy at Thomas More College and the subsequent follow‐up activities.

The workshop will concentrate on projects centered around the use of a simple telescope, namely the Galileoscopes popularized during the recent International Year of Astronomy.

Participants will be provided with a telescope kit for personal use, along with an additional kit to be assembled and used in their classrooms. During the workshop, participants will be given instruction, and in some cases, participate in sample student oriented projects that involve repeated observations with a telescope. Even a series of simple observations, such as the phases of Venus or the position of the Galilean moons of Jupiter, can provide students with a detailed insight into the scientific method and a historical perspective on the birth of modern science. Additionally, Thomas More College will serve as a hub for observations collected by students from the classrooms of the workshop participants, providing a valuable resource for further instruction and fostering a partnership between local area schools.

Hopkins Applied Physics Laboratory and MSU used the 21 M Space Tracking Antenna in an experiment involving calibration and end‐to‐end performance characterization of the spacecraft’s X‐Band system.

In the Spring of 2011, the team undertook calibration of the S‐Band system using the same technique. The 21 m system was configured with a transmitter (Tx) system designed and fabricated during this project, which transmitted a high power signal at 2,138 MHz with extreme polarization purity, which was beamed at LRO. A significant design effort was undertaken to support this calibration experiment. An S‐band feed system was developed and implemented on the 21 M as well as a high power transmitter system and associated control systems. Undergraduate student researchers have been intimately involved in engineering, implementing, testing and calibrating the GSE instrumentation, in operating the system during calibration experiments, and in analyzing data produced. LRO has returned data important to the understanding of lunar resources, which will ultimately support future human exploration of our solar system.

Keywords: lunar topograhy, synthetic aperture radar, earth station technologies ___________________________________________

63. Archival Study of the X‐ray Spectra of Blazars with the Chandra X‐ray Observatory Thomas G. Pannuti* , Benjamin J. Cahall, Caleb K. Grimes Department of Earth and Space Sciences, Morehead State University

An analysis of the X‐ray spectra of a sample of blazars that are candidates for long‐term radio monitoring observations with the 21‐meter Space Tracking Antenna at Morehead State University.

These spectra were extracted from data obtained by pointed observations made with the Chandra X‐ ray Observatory and were fit with several different models, including a simple power law model and a thermal plasma model. The main goal of this work is to identify spectral variations in the X‐ray spectra 68

POSTER ABSTRACTS

66. Cosmic X‐Ray Background NanoSat (CXBN): An Improved Measurement of the Diffuse X‐Ray Background Kevin Z. Brown*(1), Benjamin K. Malphrus(1), Jeff Kruth(1), Bob Twiggs(1), Tyler G. Rose(1), Andrew Cavins(1), Justin Hamilton(1), Garrett Jernigan(2), John Doty(3), Matthew Doty Wampler(3), Lance Simms(4) (1)Morehead State University Space Science Center, (2)University of California Berkeley, (3)Noqusi Aerospace, (4)Lawrence Livermore National Laboratory

The goal of this nanosatellite mission is to significantly increase the precision of measurements of the Cosmic X‐Ray Background in the 30‐50 keV range, thereby constraining models that attempt to explain the relative contribution of proposed sources lending insight into the underlying physics of the early universe. The mission addresses a fundamental science question that is central to our understanding of the structure, origin, and evolution of the universe by potentially lending insight into both the high energy background radiation and into the evolution of primordial galaxies. The X‐Ray background flux measurements to be made during this campaign will utilize on a semiconductor detector based on a Cadmium zinc telluride, (CdZnTe or CZT) array.

Advantages of this technology include high sensitivity to x‐rays and gamma‐rays, due to the high atomic numbers of Cd and Te, and better energy resolution than scintillator detectors. In ~1 year of operation the experiment will have collected 3 million seconds of data, reaching a broadband S/N ~250. The science mission requirements allow for the design of a relatively simple spacecraft and conops, making this mission ideal for the CubeSat form factor. The CXBN design utilizes innovative attitude determination and control systems (to keep the spacecraft sun pointing), unique communications systems at UHF and S‐bands, innovative power systems with deployable solar arrays, 3‐D printed (additive manufactured) components, and other innovations.

CXBN is a CubeSat mission that is being developed

Keywords: educational outreach, astronomy ___________________________________________

65. Visualization of Kentucky Lake P. Wang(1), S. Bhattacharyya*(1), D. White(2), N. Jacobs(3) (1)Kentucky State University, (2)Murray State University, (3)University of Kentucky

Visualization plays a critical role in transforming data into information in understanding of the behavior of a system. An accurate usable visualization requires adequate investigation to include user requirements, design requirements, development of a model and a prototype development. According to this research in visualizing the Kentucky Lake a sensor network has been deployed that collects and stores large volumes of time‐varying data to be analyzed. A visualization tool to handle the datasets requires adequate processing to produce quality graphical representations of information, otherwise not apparent through physical examination of data.

Within this visualization application a prototype application is presented that demonstrates a small‐ scale graphical implementation of a smaller dataset. This work evaluated the use of Paraview software as a visualization engine, and demonstrated the visualization of dissolved oxygen and temperature. ParaView is an application utilizing Visualization Toolkit (VTK) as the data processing and rendering engine; VTK is a development package with a scripting language interface supporting the development of 3D computer graphics, image processing, and visualization. Due to lack of data collection points often interpolation needs to be done to generate a continuous visualization. The present visualization was done using linear interpolation. The visualization can be extended to accommodate parallel computing to handle larger dataset.

Keywords: visualization, kentucky lake, paraview, color mapping ___________________________________________

69

POSTER ABSTRACTS

code and then visualize the data.

Keywords: science gateway, user interface, web design, parallel program, cluster ___________________________________________

68. Multistep Sparse Matrix Strategies for Information Retrieval on Large Datasets Wen Li*, Nicholas Lykins, Chi Shen Department of Computer Science, Kentucky State University

One of the greatest challenges each person faces in everyday life is the ability to approach a limitless body of incoming information and filter from it what is useful and meaningful for his own purposes.

In the world of computer processing, the individual developer is responsible for building complex algorithms capable of handling that information and delivering an output that consumes less memory and requires less computational time without compromising on its accuracy. The proposed multistep sparse matrix strategies have been applied to three small famous datasets, MED, CISI and CRAN, and the numerical experiments show the advantage of such an approach in terms of storage costs and query time compared with least‐squares based approach while maintaining comparable retrieval quality. Building on that, we extend this method on large datasets, such as LISA and NPL which are highly dimensional. The testing result on the LISA dataset is highly encouraging.

Considering the above approach, the K‐Means computational algorithm is used to cluster the respective documents and construct a suitable concept matrix. Most of the currently generated sequential, parallel and GPU accelerated K‐Means algorithms are intended for use with dense data structures and are thus excessively time consuming and inefficient for use with the processing of a sparse data matrix. Since most term‐document datasets are excessively sparse, a GPU based K‐ Means clustering algorithm constructed for use with sparse matrix data sets and providing for text clustering capabilities is our focus.

at low cost and on a highly constrained timeline, but with potentially significant science returns. The mission has been selected by NASA for flight in the 2nd Quarter of 2012.

Keywords: cosmic X‐ray background, CZT detector, CubeSat ___________________________________________

67. Science Gateway‐Mowic: Modern Web Interface for Clusters Daniel Cleland*(1), Chi Shen(2) (1)Department of Computer Science, University of Kentucky, (2)Department of Computer Science, Kentucky State University

High performance computing (HPC) has become the third leg of science, along with theory and experimentation. It is important to create easy to use, adaptable, extensible interfaces to these systems to allow scientists to answer new questions in a timely manner. Such interfaces should provide mechanisms to run HPC code, convert and manipulate data and visualize that data. Creating a user interface layer to the cluster, not a specific application, would provide such an interface.

Clusters require remote access, often done through ssh. Web interfaces provide expanded connection capabilities. The can be accessed from many types of and do not require the installation of the interface. Web interfaces include a wide variety of open‐source, high‐quality, end‐to‐end components. Such a web interface would also allow for others to verify or build upon the work from a distance. Mowic is a prototype cluster interface that uses Linux, Apache, PHP, MySQL, HTML, CSS, Javascript, and jQuery, all freely available, well established products. Mowic does leave the tool designer free to use any other web components in the creation of their custom tools.

It allows for custom visualization tools to be installed within it to view or manipulate datasets.

Mowic handles connections to the files and navigation of the system. Sample tools were created to view sparse matrices with the ability to zoom in and out. The system is able to run HPC 70

POSTER ABSTRACTS

organizations). Complementing the three strategic initiatives are outreach and economic development efforts, including tours of the UofL Micro/Nano Technology Center and participation in external events such as Nano Days sponsored by the Louisville Science Center.

Keywords: nanotechnology, microtechnology, software, photomasks, outreach, Kentucky, community ___________________________________________

70. Networked Cooperative Autonomous Mission Control John Roberts, Siddharta Bhattacharyya, Mike F. Unuakhalu* Computer and Technical Sciences Department, Kentucky State University

Autonomous mission control with automated reconfiguration of missions is essential to adapt to the changing dynamics of an unknown environment. The possibility of adapting a mission to the status of the vehicle, the status of the surrounding vehicles, and the environment increases with the greater use of network centric operations. This research introduces a method to create a network centric testbed implemented for cooperative networked mission control. This research is focused on creating a usable framework for autonomous vehicles to work cooperatively to complete tasks. Specifically, this research is using two unmanned autonomous vehicles (AUVs) to complete a search and intercept mission. The AUVs use infrared sensors, and visual input as primary variables for navigating unknown environments searching for the specific object. The AUVs communicate with each other to maintain cooperative status and to better make decisions.

Keywords: autonomous mission control, automated reconfiguration, networked cooperative ___________________________________________ 71. 3D Data Visualization of Bee Hive Cluster Using Sensor Net Luis E. Urbina*(1), Siddhartha Bhattacharyya(1),

Keywords: term‐document matrix, concept decomposition matrix, multistep, sparse matrix approximation, K‐Means, GPU ___________________________________________

69. Kentucky Nanonet: Connecting Kentucky's Micro/Nano Community Thomas Roussel*(1), Kevin Walsh(2), Robert Keynton(1), James Loomis(2), Mark Crain(2), Shamus McNamara(2), Curt McKenna(2), Joseph Lake(2), Ana Sanchez(2) (1)Department of BioEngineering, University of Louisville, (2)Department of Electrical and Computer Engineering, University of Louisville

The "KY nanoNET (KYNN) Initiative" is a five‐year ~$1.4M proposal (~$900K from NSF) to develop a statewide infrastructure virtual network for the advancement of micro/nanotechnology in Kentucky and the many fields that utilize this pervasive and maturing technology. The KYNN contains three distinct efforts: 1) Development of a comprehensive, web‐based regional network to integrate the micro/nano labs and resources scattered throughout the Commonwealth (similar to the NSF‐sponsored, nationally targeted NNIN and nanoHUB initiatives), 2) development of a shared software program (i.e. KRUNCH ‐ Kentucky Research Users of Nano CADtools Hub) to allow researchers across the state access to a variety of commercial TCAD tools for micro/nano/MEMS research/education, and 3) development of a centralized physical core facility (i.e. KORE ‐ Kentucky Optical REsources) to fabricate custom photomasks, which will effectively serve the needs of all micro/nano researchers/educators in Kentucky. After two years, the KYNN has added 13 “hubs” to the network and supports over 100 internal and 50 external users of the shared software.

The KY NanoNET website (kynanonet.org) has a monthly average of 974 page views (11,191 in the most recent 12 months), and has over 50 followers (Facebook, Twitter, etc). The KORE facility has written 211 masks (127 internal, 84 external) in the past 12 months, serving 9 different institutions (both industrial and academic 71

POSTER ABSTRACTS

controllers. For the Comair flight, the air traffic controller cleared the plane for takeoff from runway 22; the pilot then proceeded for further duties without checking which runway the flight was actually taking off from. Severe weather conditions, negligence or shortage of workers can also lead to delayed or undetected diagnosis of an error which can lead to an unfortunate loss of life.

Runway mishaps occur due to the lack of real time monitoring and the time gap in alerting or diagnosing a severe condition. The event response time gap can be reduced by deploying automated technology to handle constant 24/7 monitoring, detection and alerting of severe conditions by transmitting a warning signal. One such idea using this technology is the deployment of wireless sensor network to detect errors/faults on the runway and transmit warning messages to the pilot and air traffic controller in real time. With wireless sensor network deployment, crashes like that of Comair 5191 could be avoided as the pilot would be instantly notified of the length of the runways based on the signals received from the sensors deployed on different runways in an airport. The wireless sensor network could also detect severe weather conditions which can go undetected by human beings thus preventing further loss of lives.

This technology would be a commercially viable product as is discussed further in later sections.

Keywords: sensor network, vibration, data analysis, real time software ___________________________________________

Thomas Webster(1), Jeff Ashley(2) (1)Kentucky State University, (2)University of Kentucky

Scientists require tools to analyze large and complex data. Multidimensional data visualization is an efficient tool for better understanding of the behavior monitored. Remote accessibility of the visualization tool further strengthens the accomplishments of the research. This thesis is a proposed model for a Web Graphic User Interface for 2D and 3D data visualization to monitor internal condition of honey bee cluster temperature. A prototype is developed. It shows the integration of hardware and software for data acquisition, graphical transformation of data, and deployment in real time on the internet the data and information generated. Researchers, from apiculture arena in this case, can detect alarming conditions early enough to understand the issues with Bee death during winter season. Arduino, MATLAB, .NET software and parallel programming are used for sensing the interior temperature of beehive, transform the data graphically, and deploy it on Internet. Future work involves the parallel processing of the data to speed‐up the real‐time visualization.

Keywords: 3D, data visualization, sensoring, bee hive ___________________________________________

72. Vibration Monitoring and Analysis with Wireless Sensor Network (WSN) to Classify Vehicles Types Biswajit Panja(1), Siddhartha Bhattacharyya*(2) (1)Department of Computer Science, Morehead State University, (2)Kentucky State University

On August 27 2006, Comair flight 5191 departing from Lexington, Kentucky crashed, killing all passengers and all but one crew member. The basic human error leading to the crash was the shorter runway that the Comair flight took off from. The present technology to deal with runway air traffic control is the manual monitoring done by air traffic

72

POSTER ABSTRACTS

___________________________________________

74. Self‐Assembled Nanoelectromechanical System for Detecting Piconewton Forces J.M. Rathfon(1), M. Yan(2), J.F. Berret(2), R.W. Cohn*(1) (1)University of Louisville, (2)Université Paris‐ Diderot, Paris, France

Force detection from 0.1‐1000 pN is of particular interest for nanomechanical measurements of cellular biomaterials. This range spans that of other probes that are widely used by the experimental cellular and macromolecular biophysics communities, including: magnetic traps (0.05–20 pN), laser traps (0.1–100 pN), and the low‐end range of atomic force microscopes (5‐10,000 pN).

Herein we describe the self‐assembly and nanomechanical properties of a structure that is sensitive to forces over this entire range. The bead‐ on‐a‐string (BOS) nano‐electro‐mechanical system (NEMS) is a composite polymer structure of magnetic nanorods in polyethylene oxide (PEO). At dimensions of 50‐200 nm by 1 mm long the structure is so flexible that a 1 micron transverse displacement, corresponding to a 10 pN force, is easily observed visually under a light microscope.

Even higher, sub‐piconewton sensitivity (and in three dimensions) is possible by using scattering into a single quadrant‐photodetector. Therefore, the BOS NEMS structure appears capable of sensing an extended range of forces, providing simpler access to the soft biological samples under test, and being more easily interfaced to the tight working space of biological optical microscopes.

The fabrication of the structure is particularly appealing in that it can be made controllably and in parallel by simple hand brushing of polymer over a patterned array of micropillars. The weight fraction, molecular weight and brushing speed of the PEO solution determine whether one bead or a bead and satellites form. The relatively large bead volume (25 micron diameter) enables large deflection with modest magnetic field gradients.

Keywords: nanomechanics, directed self‐assembly,

MATERIALS SCIENCE AND ADVANCED MANUFACTURING

73. Adsorption of Chlorophyll a on to Hydrophobic and Hydrophilic Surfaces Using Broadband Spectroscopy with Single‐Mode Integrated Optical Waveguides Rodrigo S. Wiederkehr*, Geoffrey C. Hoops, Sergio B. Mendes Department of Physics and Astronomy, University of Louisville

In this work, we experimentally investigated the effects of sodium chloride on the molar absorptivity and surface density of a submonolayer of chlorophyll a adsorbed onto hydrophilic and hydrophobic solid/liquid interfaces. Those investigations were made possible by a broadband spectroscopic platform based on single‐mode, integrated optical waveguides which allows for extremely sensitive spectroscopic detection of analytes immobilized at submonolayer levels.

Chlorophyll a with a constant bulk concentration (1.4 μM) was dissolved in phosphate buffer solutions (7 mM) of neutral pH, but with different sodium chloride concentrations. For a buffer solution of 1 mM of sodium chloride, the measured surface density of chlorophyll a was 0.209 pmol/cm2 for a hydrophilic and 0.125 pmol/cm2 for a hydrophobic surface. For a phosphate buffer solution of 10 mM of sodium chloride, the measured surface density of chlorophyll a was 0.528 pmol/cm2 for a hydrophilic and 0.337 pmol/cm2 for a hydrophobic surface. Additionally, a hypsochromic shift of the Soret band was observed for the adsorbed pigment in correlation with an increase in buffer ionic strength. The adsorption of chlorophyll a onto different surfaces can play an important role to elucidate several processes found in nature and provide a rationale for bio‐inspired new material technologies.

Keywords: chlorophyll a, molecular surface adsorption, waveguide spectroscopy, atomic layer deposition, molecular vapor deposition PEG silane, perfluorodecyltrichlorosilane 73

POSTER ABSTRACTS

chemistry and chemical physics.

Keywords: pulsed‐field Ionization, high‐resolution ion spectroscopy, and transition metal oxide clusters ___________________________________________

76. Novel Lead‐Free Piezoelectric Ceramics in the Solid Solution BiFeO3‐BaTiO3 Serhiy O. Leontsev*, Richard E. Eitel Department of Chemical and Materials Engineering, University of Kentucky

Piezoelectric materials are widely used in many areas of science and technology due to their electromechanical properties. The transformation of mechanical energy into electrical signals and vice versa based on the piezoelectric effect has led to the development of a variety of sensor devices and piezoelectric actuators. The most technologically important piezoelectric material is lead zirconate titanate PbZrO3‐PbTiO3 (PZT), however, the commercial manufacture and application of PZT as a lead‐based material represent serious health hazards. The need to reduce environmental contamination by lead‐based substances has created the current drive to develop alternative lead‐free piezoelectric materials. The present work describes investigation of the novel lead‐free piezoelectric ceramics in a solid solution of BiFeO3‐ BaTiO3 (BFBT). BFBT ceramics were prepared via the solid‐state route with addition of manganese oxide in order to increase the DC resistance.

Piezoelectric d33 coefficients of 116 pC/N (low‐ field, Berlincourt) and 326 pC/N (high‐field) are reported. Piezoelectric measurements using the Rayleigh law under applied large DC electric field indicated an increased low‐field piezoelectric d33 coefficient to 150 pC/N. The DC bias is believed to stabilize the ferroelectric domain structure leading to stronger intrinsic and extrinsic contributions to the piezoelectric response in BFBT. Bright field TEM imaging confirmed formation of macroscopic domains following high field poling from initially frustrated domain state indicating the ability to induce long‐range polarization order in BFBT

polymers, magnetics ___________________________________________

75. High‐Resolution Pulsed‐Field‐Ionization Ion Spectroscopy of Transition‐Metal‐Oxide Clusters L. Wu*, Y. Liu, M. Roudjane, J. Lee, C. Zhang, S. Krasnokutski, D.S. Yang Department of Chemistry, University of Kentucky

Transition metal oxides are widely used as both catalysts and catalyst supports in petroleum refining and other industrial processes. A catalyst is a substance that initiates a desirable chemical reaction or speeds up a reaction that would otherwise be too slow to be economical. However, catalyst development is still carried out by try and error, and the rational design of new catalysts with predictable properties is a long‐term goal requiring both basic and applied research. This KSEF‐ sponsored project focuses on the fundamental aspects of the catalyst development. We use laser‐ assisted synthesis to prepare metal oxide clusters in gaseous supersonic jets, mass spectrometry to measure the oxide abundance and distribution, and high‐resolution pulsed‐field‐ionization ion spectroscopy to search for electronic‐vibrational spectra. The outputs of this research include accurate ionization and vibrational energies, electronic states, and geometric structures. The project expands our research program in a new direction, stimulates additional research in cluster science, and increases the basic knowledge about the size‐dependent properties of the transition metal oxide clusters. This work opens up new area for high‐resolution ion spectroscopic applications to transition metal clusters and enhances Kentucky’s emerging international reputation in this field. With the preliminary results from this grant, we have already been awarded a research grant of $445,560 from the National Science Foundation and a grant of $100,000 from the Petroleum Research Fund of the American Chemical Society and presented several papers at national and international meetings. With this grant, we are training several graduate and postdoctoral students in modern physical 74

POSTER ABSTRACTS

membrane, allowing for a switchable membrane valve.

Keywords: energy storage, membrane, nano fluidics ___________________________________________

78. Tuning the Pore Structure of Surfactant‐ Templated Mesoporous Titania Films Qing Liu Wu*, Navaladian Subramanian, Stephen E. Rankin Department of Chemical and Materials Engineering University of Kentucky

We describe methods to tune the synthesis of well ordered mesoporous titania thin films (MTTFs) fabricated by Evaporate‐Induced‐Self‐Assembly with Pluronic surfactant template P123. Because P123 has average structure (PEO)20(PPO)70(PEO)20 [where PEO = poly(ethylene oxide) and (PPO) = poly(propylene oxide)], the concentrations of polar and nonpolar additives can be adjusted to tune wall thickness, pore size and mesophase of the final products. For instance, the wall thickness of MTTFs can be tuned from 5 nm to 7 nm by adjusting the molar ratio of titanium precursor to P123 due to cooperative assembly of Ti species with PEO blocks.

Alternatively, organic species can be introduced to interact with PPO blocks for pore tuning. When poly(propylene glycol) (PPG) is added to films aged at a temperature where PPG exhibits hydrophobic behavior, the mesopore size of the films increases up to as much as 6.4 nm and secondary pores ~2.4 nm in diameter are introduced due to partitioning of PPG between the polar titania‐rich phase and the P123 micelles. On the other hand, aging the PPG‐containing films at a temperature where PPG exhibits hydrophilic behavior leads to a hierarchical structure composed of voids >200 nm in diameter and ordered <12 nm pores. As one more example, adding 1‐butanol gives transparent MTTFs with distorted 3D hexagonal (space group R‐3m) symmetry. Grazing incidence small angle x‐ray scattering, electron microscopy and simulated scattering confirm that the butanol‐containing

ceramics. It is believed that the results of this work will contribute to the development of a family of lead‐free piezoelectric materials based on BiFeO3‐ BaTiO3 system.

Keywords: bismuth ferrite, barium titanate, lead‐ free, piezoelectric ceramics, crystal structure ___________________________________________

77. Nanoscale Bubble Valves on CNT Membranes for Chemical Energy Storage Xin Su, Ji Wu, Bruce J. Hinds* Department of Chemical and Materials Engineering, University of Kentucky

Chemical energy requires stable electrodes with low over‐potential, fast mass transport, and a valve system to stop diffusion while in the storage mode.

Carbon nanotube membranes [1] are an exciting platform for energy storage since the mass transport through CNT cores is a thousand fold faster than pores of conventional materials, graphite is highly conductive and stable, and CNT surfaces can be functionalized with catalyst metals or complexes for a low over potential [2‐3].

However an effective valve to turn off the membrane during storage time needs to be developed. Nano‐scale bubbles have the potential to be nearly ideal valves to completely cover the pore entrance and reversibly turn off the membranes. Nanoscale bubbles have been observed to have unexpected stability, with internal pressures of only 1 atm, on hydrophobic surface due to the formation of a small contact angle [4]. Nano‐scale bubbles are prone to form inside of the nanochannels and the growth of hydrogen nanoscale bubble can be controlled by electrochemical current dosing. Presented here is a novel electrochemical method to generate nm‐ scale bubbles at the tips of CNTs that can temporarily block the membrane. 92% blocking efficiency is achieved when the bubbles are stabilized in a 30‐60 nm diameter ‘wells’ at the tips of CNTs. The nanoscale bubbles can be removed with 0.004 atm applied pressure on the feed solution to recover the transport through the CNTs 75

POSTER ABSTRACTS

and Biomedical Applications Haluk Karaca*(1), Sayed Saghaian(1), Irfan Kaya(1), Emre Acar(1), Mohammad Souri(1), Burak Basaran(1), Bedri Baksan(2), Ronald Noebe(3) (1)University of Kentucky, (2)Osmangazi University, (3)NASA Glenn Research Center

Shape memory materials are an important class of smart materials with the ability to recover mechanically induced strain with a change in temperature or magnetic field and tunable material properties (e.g. Young’s modulus, damping properties). They have the ability to sense the changes in environment and respond accordingly.

They simplify products, add features, improve performance, and increase reliability with relatively little mechanical complexity. Shape memory alloys have remarkable material properties such as they can produce very high actuation strain (4‐10%), stress (~100‐400 MPa) and work output (~10 MJ/m3) as a result of reversible martensitic phase transformations. Shape Memory Polymers are polymeric smart material that have the ability to return from a deformed state (~100%) to their original (permanent) shape induced by an external stimulus (trigger), such as electric, temperature, magnetic field, light or solution. In this poster, results from the thermomechanical characterization of the high temperature and high strength shape memory and shape memory polymers for aerospace and biomedical applications will be presented.

Keywords: shape memory alloys, shape memory polymers, phase transformation, aerospace, biomedical ___________________________________________

films are composed of ordered arrays of cage‐like cavities of tunable size.

Keywords: mesopore, titania thin film, wall thickness, pore size, hierarchial pore, 3D hexagonal mesopore, PPG, butanol ___________________________________________

79. Thermomechanical Characterization of Environmentally Conditioned Shape Memory Polymers Jared T. Fulcher* and Y.Charles Lu Department of Mechanical Engineering, University of Kentucky

Most air vehicles today are designed to obtain certain performance capabilities at the cost of operational flexibility. The ability to have a vehicle capable of adapting for numerous mission elements would be very advantageous. The design of the reconfigurable material systems to be used in a multifunctional air vehicle varies greatly. Shape memory polymers (SMPs) are novel class of active polymers that have been considered for the development of reconfigurable air vehicles.

However, the durability of the SMPs has not been fully investigated to ensure they function properly in relevant environments. In this project, epoxy‐ based SMPs were conditioned separately in simulated service environments designed to be reflective of anticipated performance requirements. The shape recovery ability and mechanical properties of the conditioned SMPs were evaluated. Results show that environmentally conditioned SMPs generally exhibit decreased glass transition temperatures and higher moduli and strain rate sensitivities in comparison to an unconditioned one. Environmental conditioning also affects the shape recovery abilities of the SMPs if the recovery temperatures are set low.

Keywords: shape memory polymer, environmental conditioning, durability, reconfigurable material ___________________________________________

80. Novel Shape Memory Materials for Aerospace 76

POSTER ABSTRACTS

Properties of hematite a‐ Fe2O3 nanowire arrays for photoactive water splitting on the electrode are shown. The nanowire arrays are synthesized by thermal and plasma oxidation of commercial steel samples. In comparison, the Fe2O3 nanowire arrays grown using thermal oxidation of iron foils exhibited no photoactivity due to the presence of a thick (approx. 30 micron) interfacial layer and non‐ hematite phases. The photoactivity of plasma grown iron oxide NW arrays is supreme to other growth methods yielding a significant photoactivity of 0.255 mA/cm2 at 0.3 V SCE in 1M KOH . If the photocurrent is inhibited by the presence of a thin amorphous oxide sheath on the surface of the nanowires due to exothermic reactions on the surface, it can be easily removed by diluted hydrofluoric acid which restores photoactivity of the electrode.

Keywords: a‐Fe2O3, hematite, iron oxide, nanowires, plasma synthesis, photochemical activity, water splitting, hydrogen manufacturing, solar cell ___________________________________________

83. Advanced MEMS Grayscale Lithography Mask Generation Software James Loomis*(1), Curt McKenna(2), Mark Crain(2), Thomas Roussel(2), Ana Sanchez(2), Joseph Lake(2), Shamus McNamara(2), Kevin Walsh(2) (1)Department of Mechanical Engineering, University of Kentucky, (2) Department of Electrical and Computer Engineering, University of Louisville

Grayscale lithography is a technique used to expose different areas of a photosensitive substrate to various intensities of light. By controlling the amount of light each region of the substrate is exposed to, the depth at which photoresist is developed can be carefully controlled. This process can result in the creation of complex 3D structures in photoresist simply from using a single exposure lithographic technique. While it provides an extremely versatile tool for Micro‐Electro‐ Mechanical Systems (MEMS) fabrication, grayscale lithography is a relatively underutilized process.

81. High Temperature Polymer Matrix Composites for Aerospace and Space Applications Spandana Pulla*, Y.Charles Lu, Fuqian Yang, Haluk Karaca Department of Mechanical Engineering, University of Kentucky

Polymer matrix composites (PMCs) have been increasingly used for high temperature applications in aerospace industries. The matrix systems in the high temperature PMCs are predominantly thermoset polymers. One of the major concerns in using polymer matrix composites at high temperature environments is the thermo‐oxidative degradations of the polymer matrix and the matrix‐ fiber interphases. Exposed to elevated temperature, the free surfaces of PMCs are susceptible to oxidation. When exposed to thermo‐ mechanical loading, the result is accelerated degradation and ply cracking which in turn introduces new free surfaces. Ultimately, the thermo‐oxidative degradation reduces the life and durability of the composite system. The present project studied the thermo‐oxidative degradation and resultant mechanical properties of the PMCs through experimental testing and numerical simulations.

Keywords: polymer matrix composites, thermo‐ oxidative aging, interphase, finite element modeling ___________________________________________

82.

Hematite Nanowire Arrays for Photoelectrochemical Water Splitting Boris Chernomordik(1), Harry B. Russell*(1), Uros Cvelbar(2) Jacek B. Jasinski(1), Vivekanand Kumar(1), Todd Deutsch(3), Mahendra K. Sunkara (1) (1)Conn Center for Renewable Energy and Environmental Stewardship, and Chemical Engineering Department, University of Louisville, (2) Plasma Lab F4, Jožef Stefan Institute Jamova 39, SI‐1000 Ljubljana, Slovenia‐EU, (3)National Renewable Energy Laboratory 77

POSTER ABSTRACTS

mm/s were obtained for an open tube, and a pressure difference greater than 1 kPa was obtained in a closed container.

Keywords: gas pump, solar power ___________________________________________

85. Angle‐Multiplexed Waveguide‐Resonance Sensor of High Sensitivity and Nano‐Second Time Resolution Courtney L. Byard, Xue Han*, Sergio B. Mendes Department of Physics and Astronomy, University of Louisville

We report here the experimental results of an optical sensor based on a waveguide resonance with a high quality factor formed by a dielectric film (Al2O3) deposited over a noble metal material (Ag, Au). Based on a judicious design of the layer thicknesses and a fabrication process that delivers a highly transparent dielectric film over a metal surface, we demonstrate a device that is 39 times better than conventional surface plasmon resonance sensor for probing refractive‐index changes. In addition, we have created an optical experimental setup based on diffraction‐limited lenses that is able to collect the full angular spectrum and resolve the sharp waveguide resonance. Such configuration has enabled us to reach nanosecond time resolution and experimental evidence is provided by the luminescent signal of a sub‐monolayer of a ruthenium complex adsorbed to the sensor surface.

The highly sensitive and fast detection technique demonstrated here is expected to find useful applications in studies of the fast‐dynamics of surface adsorbed molecules

Keywords: waveguide resonance, surface plasmon resonance, biosensor, time‐resolved detection, nano‐second time resolution ___________________________________________

The main drawback of grayscale lithography involves the time‐intensive creation of mask files required to generate complex 3D structures.

Therefore, the University of Louisville Micro/Nano Technology Center (MNTC) team designed a process to simplify the task of generating mask files. Custom software was written which automatically converts SolidWorks parts into grayscale mask files accepted by a Laser Pattern Generator. By allowing parts designed within SolidWorks to be directly fabricated into MEMS structures, a large preexisting pool of engineering professionals are now able to take advantage of the ability to participate in MEMS design with no additional training required.

Keywords: grayscale lithography, SolidWorks, solid models, MEMS, microfluidics, photolithography ___________________________________________

84. Solar Thermal Powered Knudsen Gas Pump Stephanie Miles, Alexander Bell, Kunal Pharas*, Shamus McNamara University of Louisville

This paper reports on a Knudsen gas pump that may be operated using solar radiation. The pump may be considered environmentally friendly as it requires no external power supply. The Knudsen pump presented here features no moving parts, is thermally driven, has a simple design, has no need for batteries or other power supplies, and it is relatively simple to fabricate. Two Knudsen gas pumps were designed and fabricated. Both pumps utilize the same basic design: a nanoporous material, an inlet tube, a heat sink, and a method of heating the exposed portion of the nanoporous material. Gas will flow through the nanoporous material when a temperature gradient is applied due to the thermal transpiration effect. The velocity of a drop of water in the inlet tube was measured to obtain the flow rate of each pump.

The gas flows from the cold to the hot side of the nanoporous material. When solar energy heated the metal of either pump, the drop would start moving out of the tube. Flow velocities exceeding 1 78

POSTER ABSTRACTS

index as compared to the nonfunctionalized SAPO‐ 34 membrane.

Keywords: zeolite membranes, amino groups, CO2 separation ___________________________________________

88. Matrix Isolation Spectroscopy of Copper‐ Naphthalene Jason F. Fuller*, Dallas W. Critchfield Department of Chemistry, Eastern Kentucky University

The interaction of transition metals with p‐ electrons is central to organometallic chemistry and constitutes a significant body of work in this field, yet surprisingly little is known about the bonding and geometry of transition metal‐ polycyclic aromatic hydrocarbon (M‐PAH) complexes. Additionally these M‐PAHs are suspected to exist in the interstellar medium (ISM), and may contribute to the unidentified interstellar infrared emission bands. This poster will present the matrix isolated infrared absorption spectrum and theoretical characterization of the Cu‐ Naphthalene complex. To produce this complex, laser ablated copper is co‐deposited with a 1‐3% argon/naphthalene mixture on a barium fluoride window cooled to approximately 10 K by a closed cycle helium cryostat. The trapped species are then probed with FTIR spectroscopy. Vibrational frequencies and electronic energies for both the eta‐2 and eta‐6 binding mode of Cu‐Naphthalene were computed at the of B3LYP/6‐311+G(d,p) level of theory. And through comparison of the observed and computed vibrational frequencies, the gross geometry of complex and the binding mode of copper to the p system are deduced. This work allows for a better understanding of metal‐ PAH interactions, the chemical and physical properties of the complexes, and their roles in the ISM.

Keywords: polycyclic aromatic hydrocarbons, PAH, interstellar medium, ISM, infrared, IR, transition metals

86. Hybrid Organic‐Inorganic Polyoxometalate Materials Bangbo Yan*, Yan‐Fen Li, Amanda Semelser, Christopher N. Carmichael, Samantha A. Hodsdon Department of Chemistry, Western Kentucky University

Self‐assembly of the robust Keggin clusters and metal‐organic coordination complex building blocks under hydrothermal conditions gives a number of new organic‐inorganic hybrid solid compounds. These compounds were studied by Single crystal X‐ray, UV–Vis, IR spectroscopy and Thermogravimetric analysis.

Keywords: hybrid organic‐inorganic, polyoxometalate materials ___________________________________________

87. Amino‐Functionalized SAPO‐34 Membranes for CO2 Separation Surendar R. Venna, Moises A. Carreon* Chemical Engineering Department, University of Louisville

SAPO‐34 seeds and membranes were functionalized with several organic amino cations such as ethylenediamine, hexylamine and octylamine. The successful incorporation of the amino groups in the SAPO‐34 framework was confirmed by FTIR and XPS. The resultant SAPO‐34 membranes were evaluated for the separation of CO2/CH4 and CO2/N2 gas mixtures. CO2/CH4 selectivities as high as 245 with CO2 permeances of ~ 5 x10‐7 mol/m2 s Pa at 295 K and 138 KPa, were observed for an optimum ethylenediamine functionalized membrane, which corresponded to a ~ 40% increase in separation index as compared to the nonfunctionalized SAPO‐34 membrane.

Similarly, CO2/N2 separation performance was highly improved with the incorporation of ethylenediamine. CO2/N2 selectivities as high as 39 with CO2 permeances of ~ 2.1 x10‐7 mol/m2 s Pa at 295 K and 138 KPa, were observed for an optimum ethylenediamine functionalized membrane, which corresponded to a ~ 167% increase in separation 79

POSTER ABSTRACTS

90. Fabrication of Nanoporous Nickel as an Alternative to Raney Nickel Lei Wang, Xu Jiang*, T. John Balk Department of Chemical and Materials Engineering, University of Kentucky

Raney nickel is an important industrial catalyst but is also highly pyrophoric and must be protected from air exposure or stabilized by mild heating. An alternative form of nanostructured nickel (nanoporous nickel, or np‐Ni) was developed as a thin film in this research project, and this material was found to avoid the pyrophoric problem. High purity (100% Ni content) np‐Ni thin films were fabricated by dealloying NiMg precursor films. The nanoporous structure exhibited ligaments with a size of 7 nm, comparable to that of Raney nickel.

Several precursor systems (NiCu, NiAl, NiFe and NiMg) were investigated as precursors for fabrication of np‐Ni, and NiMg yielded the most consistent, open‐porosity structure. Details of the fabrication method, structural characterization and chemical analysis, as well as electrochemical and mechanical performance of np‐Ni will be presented.

Keywords: Np‐nickel, thin film, thermal cycle, dealloying, CV, XPS, relative density ___________________________________________

91. Selectively Stimulated Self‐Assembly of Polymer Thin Films into Nanoscale Suspended Structures Jeremy M. Rathfon*, Pavan K. Putcha, Robert W. Cohn ElectroOptics Research Institute and Nanotechnology Center, University of Louisville

The fabrication and selective laser patterning of polymer thin films into arrays of nanofiber air‐ bridges is reported. Fiber formation is initiated by using a focused laser beam to thermally nucleate holes in a 20‐1000 nm thick polymer film that is supported on top of an array of micropillars. Then heating above the glass transition temperature produces hole growth through controlled

___________________________________________

89. Passive, Non‐Contact Remote Sensing of Displacement Using High Dynamic Range Optical Sensors Jeffrey R. Hay*, John F. Kielkopf, John Naber University of Louisville

The ability to measure small changes in position accurately in real time has many practical applications. Conventional methods are costly and require physical contact or close proximity to the target. We have developed an inexpensive, non‐ contact, passive technology capable of remotely sensing spatial displacements smaller than a micron using high dynamic range optical sensors, low‐noise electronics, and in some cases standard video equipment. In biomedical applications, the technology provides a reliable respiration monitor, and a non‐invasive tool to assess the cardiovascular system. In civil engineering, it provides remote sensing of the structural integrity of bridges. Through analyses that identify principal resonant frequencies and displacements of the bridge under load, we identify key aspects of bridge dynamics and relate them to its structural health.

The current best practice to visually inspect bridges is slow, costly, and potentially dangerous. Our approach surveys the structure at a distance in natural daylight quickly and easily without the need to be present on the bridge. Our technology may also identify structural deterioration hidden from view, since it senses and interprets the response of known components to normal load dynamics due to traffic, wind and background seismic noise. This offers an affordable method to monitor a bridge's health routinely, as well as to provide a prompt large scale assessment of the stability and health of critical infrastructure in the event an earthquake leaves damage over a large area.

Keywords: displacement, structural health, bridges, non‐contact, remote sensing, passive, biomedical ___________________________________________

80

POSTER ABSTRACTS

MPCs were characterized by 1H NMR, Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), energy dispersive X‐ray (EDX) analysis, X‐ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA) to determine the size, metal composition, and ligand composition.

The catalytic activity of the synthesized Pd and PdAg MPCs was examined using allyl alcohol as a substrate. Gas chromatography (GC) and NMR results show that C8NH2‐PdAg 10:1 MPCs are more efficient catalysts for the hydrogenation of allyl alcohol to propanol while C8NH2‐Pd MPCs are 50% and C6S‐Pd MPCs favor the isomerization of allyl alcohol to propanal. Differences in the catalytic activities among the various monolayer coatings for Pd(C8NH2)177‐x(C6S)x, where we varied x to be 10, 16, and 32, are attributed to the poisoning effect of the C6S ligands. The turnover frequencies (TOFs) of the Pd and PdAg MPCs catalysts ranged from 0 to 61 mol H2/ (mol Pd * h) and 28 to 94 mol H2/ (mol Pd * h) for the hydrogenation and isomerization of allyl alcohol, respectively.

Keywords: monolayer protected clusters, catalysis, palladium, silver, hydrogenation, allyl alcohol ___________________________________________

93. Electron‐Beam‐Induced Deposition of Metal Nanostructures from Liquid Precursors G. Schardein*, E. Donev, A. Chamberlain, C. Samantaray, J. Wright, S. Leontsev, J. T. Hastings University of Kentucky

Focused electron‐beam‐induced deposition using bulk liquid precursors (LP‐EBID) provides a new approach to nanoscale direct patterning. LP‐EBID replaces the gas‐phase precursors typically used for electron‐beam induced deposition with aqueous solutions. This novel approach has shown greatly increased material purity compared to EBID using metalorganic and trifluorophosphine gaseous precursors. In addition, liquid precursors are readily available, inexpensive, easily handled, dissipate charge from insulating substrates, and can greatly increased deposition rates. Because of its versatility

dewetting, leading to the formation of fiber bridges. Using a rapid laser scanner or controlled motion stage, a custom array of holes is laser‐ written, and then, following thermal annealing a custom array of fibers forms to complete the lithographic process. The structures fabricated with this laser annealing technique have potential for use in devices that require regular diameters, structure, and orientation, in specific two and three‐dimensional architectures with point‐to‐ point connections; e.g., in nanoelectronics, microelectromechanical systems (MEMS), microfluidics, optical sensors, and nano‐optics.

Several studies have been performed using films that are linearly tapered in thickness. In one of these studies, the scaling relationship between laser energy and nucleated hole diameter is established and reported. In addition to the ability to custom pattern arrays of fibers, the major new outcome of this study has been that fibers formed with prenucleated holes are much more uniform in diameter than previous studies that only depended on random nucleation. This study was funded by a KSEF award.

Keywords: nanolithography, directed self‐ assembly, polymers, rheology ___________________________________________

92. Characterization and Catalytic Properties of Pd and PdAg Monolayer Protected Clusters Monica A. Moreno*, Lyndsay N. Kissell, Francis P. Zamborini Department of Chemistry, University of Louisville

We successfully synthesized Pd monolayer‐ protected clusters (MPCs) coated with octylamines (C8NH2), hexanethiolates (C6S), mixed monolayers of C8NH2/C6S ligands, and PdAg (10:1) stabilized with C8NH2. These nanoparticles exhibit significantly different reactivities with hydrogen gas and different stabilities against H2‐induced aggregation depending on the ligand and metal composition of the MPCs as determined by UV‐vis spectroscopy and electronic measurements in solution and as solid state films, respectively. The 81

POSTER ABSTRACTS

and higher purity, LP‐EBID appears promising for rapid device prototyping and lithographic mask repair. Here we report our recent studies concerning the deposition of multiple metals (Pt, Au, Ag, Ni, and Cr) as well as two different alloys (Au‐Ag, Au‐Pt) using LP‐EBID. We find that the noble metals deposit with higher purity (typically >90at.%) while Ni and Cr incorporate greater contamination from the precursor. Resolutions as small as 20‐nm half pitch have been obtained, but vary based on material, precursor, and precursor concentrations. In addition, we show that the alloy composition can be controlled based on the ratio of precursor ions in solution. Finally, we demonstrate deposition on multiple surfaces (polyimide and silicon nitride) as well as on a separate Si substrate.

Keywords: e‐beam, deposition, nanotechnology, patterning, alloy ___________________________________________

tooth. The complete 3D model of the human jaw has great importance in the research of dentistry surgical simulation. Therefore our work has five parts: 1. The Surface Model: Designing and Developing algorithms to create a 3D model of the surface of the teeth form 2D video images. 2. The 3D Teeth Library: The 3D model library of real extracted human teeth. 3. Matching the Library: The Matching and Morphing process of each tooth.

4. Fusion: Fusing and Morphing partial info from the Surface Model, the Library model and the available x‐rays to create the complete 3D Model of the Human Jaw. 5. A new intra‐oral camera: The development of new automatic intra‐oral camera conceptual prototype.

Keywords: dental mold, 3D teeth imaging ___________________________________________

95. Certified Reference Standards and Stable Isotope Internal Standards for Equine Medication Regulation Julio Gutierrez*(1), Rodney Eisenberg(2), Gabrielle Herrensmith(1), Charlie Hughes(1), Sihui Long(3), Li Tiong(3), Thomas Tobin(1) (1) Maxwell H. Gluck Equine Research Center, University of Kentucky [www.thomastobin.com], (2) Frontier BioPharm, LLC [www.frontierbiopharm.com], (3) Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky

The regulation of equine competitive events requires defined regulatory thresholds for residues of therapeutic medications, thereby requiring accurate forensic quantification of these residues.

This creates a need for certified reference standards and stable isotope internal standards for use in medication analysis. Our research group has synthesized about 40 reference standards and has provided at least 20 unique certified standards and/or their appropriate stable isotope internal standards to racing chemists world‐wide. There is an ongoing need for reference standards and internal standards to fulfill world‐wide requirement to scientifically regulate equine therapeutic

TECHNOLOGY DISPLAYS

94. 3D Imaging Dental Probe for Orthodontic Treatment Aly Abdelrehim*, Ross Pusateri, Mike Miller, Aly Farag Computer Vision and Image Processing Lab, Department of Electrical and Computer Engineering, University of Louisville

Due to the difficulties of setting up a data acquisition system inside the mouth, we use an intra‐oral camera to capture a sequence of calibrated images. The objective of our research is to construct a complete 3D model of the human jaw using the surface and teeth database models.

The surface model produced by our methods gives the crown part of each tooth which is matched to 3D models in a teeth‐database. Our surface model then replaces any conflicting information of the crown information of the match 3D model of the database, and the root structure of the 3D model is morphed to best match the known root structure based on any available x‐rays, producing a complete 3D tooth structure of the subject for each 82

POSTER ABSTRACTS

___________________________________________

97. Wireless Temperature Sensing System for Children Doug Jackson*, David Miller, John Naber, Kevin Walsh, Charles Woods, Brad Keller Electrical and Computer Engineering Department and Medical School, University of Louisville

Four engineers with the University of Louisville’s (UofL) Electrical and Computer Engineering (ECE) department have teamed with two pediatric physicians from UofL to develop and validate a system to remotely monitor the body temperature in young children. This team of engineers and doctors has also engaged two business and marketing experts to help commercialize the technology through a start‐up company called Simon Sounds LLC. The purpose of this novel and potentially patentable device is to allow parents to monitor in real‐time the temperature of their young children and alert them if the temperature has exceeded a predetermined threshold. This technology alerts the parents to a rapid change in body temperature, which can increase the risk of neurologic events (seizures). A prototype of the wireless transmitter and receiver to continually monitor temperature remotely will be demonstrated. In addition to showing temperature and sounding an alarm locally, this system will also demonstrate the use of a smart cell phone application to communicate to the parent or caregiver anywhere.

Keywords: wireless, febrile seizure, temperature monitoring ___________________________________________

98. Exosomal RNA and Protein Expressions Differentiate Pregnancies Destined to Deliver Preterm Douglas D Taylor, Cicek Gercel‐Taylor Obstetrics, Gynecology, and Women's Health Background: While preterm births account for 12.7% of live births in the US, more than 60% of

medication use in equine competitive events.

Keywords: equine forensic chemistry, medication regulation, quantitative analysis, regulatory analytes, certified reference standards, stable isotope internal standards, chemical synthesis ___________________________________________

96. Functional Analysis Of Genes Involved In The Caste Differentiation In Termites Zhen Li(1), Xiangrui Li*(1)*, Qian Sun(1), Li Tian(1), Susan Jones(2), Mike Potter(1), and Xuguo Zhou(1) (1)Department of Entomology, University of Kentucky, (2)Department of Entomology, The Ohio State University

There are over 2,700 species of termites on this planet. Because of their cryptic nature and unique capability of digesting woody materials, termites represent a tremendous challenge to the human society, and are considered by many as one of the most destructive insect pests in the world. The combined damages and control costs exceeds $30 billion annually. Termites have been controlled predominantly by the synthetic chemicals. The persistency and highly toxic nature of termiticides, however, post a serious threat to our surrounding environment and human health. To reduce our reliance on broad‐spectrum termiticides, we developed a RNA interference (RNAi)‐based control alternative using the termites own gene against them. In this study, a group of genes involved in the worker to soldier caste differentiation process have been cloned and functionally characterized. By suppressing the expression of these genes, the developmental process of termites was disrupted and the colony fitness was compromised. In addition, at higher dosage challenged termites exhibited molting defects and high mortality. Results indicate genes involved in the termite development are viable target sites for the RNAi‐based genetic controls.

Keywords: RNA interference, Reticulitermes flavipes, termite control, caste differentiation, functional characterization 83

POSTER ABSTRACTS

Based on market research provided by the Kentucky Commercialization Fund grant COMMFUND‐1280‐RFP‐011, the PI and the WKU Research Foundation have entered into a joint venture with HitCents, Inc. to produce commercial software that utilizes the patent‐pending wavelet‐ based algorithm developed by the PI in part during the course of the research in the KSEF R&D Excellence grant KSEF‐1653‐RDE‐011. This algorithm uses a wavelet basis developed by the PI during a previous KSEF R&D Excellence grant KSEF‐324‐RDE‐ 003 and EPSCoR Research Enhancement Grant UKRF 4‐65752‐04‐360. The software allows the user to input the location and width of various peaks in the user’s collected spectra (PFTNA, XRF, etc.) that are indicative of the presence of elements in their test material, and uses wavelet technology to eliminate background distortions and provide an accurate count for each peak. The software also allows the user to search an input substance library to help identify the test material. This poster will touch lightly on the steps taken by the algorithm, with references to more elaborate descriptions, and will show screen‐shots taken of the software in use. Contact information will be given for individuals and companies wishing to license the use of the software. The software will be available starting in June 2011 for a free trial before purchase via internet download from peakletanalysis.com.

Keywords: wavelets, spectrum analysis, elemental detection, multiwavelets, HitCents ___________________________________________

100. Broadcast Methods for the Elimination of Random Anomalous Peak Loads Phil Womble*, Jonathan Quiton, Kyle Moss Western Kentucky University

A problem faces around the globe is that of increasing power consumption. Population growth combined with increased demand from industry lead to a geometric progression of power consumption. The intermittent nature of these heavy demands results in peak power loads on the

neonatal mortality results from births occurring prior to 30 weeks gestation. Since miRNA and protein profiling of placental biopsies may be useful in diagnosing preterm birth, our hypothesis is that specific miRNAs and proteins associated with circulating exosomes will exhibit the same utility, in a non‐invasive manner, allowing its use in screening asymptomatic populations. Methods: This study utilized sera from pregnant women at 14‐16 weeks gestation, subsequently delivering at term (>37 weeks, n=21) or preterm (24‐35 weeks, n=21).

These were matched for age, race and BMI. Exosomes were isolated and exosomal proteins and total RNA were extracted. miRNAs were isolated and profiled using qRT‐PCR arrays for 88 specific miRNAs. Exosomal proteins were profiled and defined using 2D‐DIGE and ion trap mass spectrometry. Results: Of 88 specific miRNAs, circulating exosomes from preterm pregnancies expressed elevated levels of 18 (>2‐fold), while 13 miRNAs exhibited diminished levels (>2‐fold) versus term pregnancies. Proteomic analyses of exosomes identified 194 proteins. Of these, 134 were shared by exosomes from term and preterm pregnancies, 21 appeared to be unique to pregnancies delivering at term and 39 were linked with preterm deliveries. Conclusions: Differences in protein and miRNA associated with circulating exosomes can be identified in preterm versus term delivering pregnancies. Proteins linked with preterm‐derived exosomes are associated with organ injury/cell compromise and cell‐mediated immunity. Profiling of exosomal miRNA and protein circulating in pregnant women provides early markers predicting preterm birth.

Keywords: preterm, early detection ___________________________________________

99. Peaklet Analysis: Software for Fast, Accurate, and Automated Analysis of Spectrum Data Bruce Kessler* Applied Physics Institute, Western Kentucky University

84

POSTER ABSTRACTS

physical parameters (pressure, temperature, humidity, etc.) in the container as well as the automated remote sampling of the container’s content and/or free headspace. The collected data can be analyzed to perform real‐time monitoring of important industrial processes, like the rate of alcohol fermentation. The development of an integrated, wireless sensor system for the real‐time monitoring of a container’s content is central to the implementation of an automated response system.

We plan to develop an automated response system using WST in order to monitor the contents of closed containers stored for long periods of time.

This innovative WST monitoring system will save the distillery industry the expensive and often unsafe manual monitoring practice currently in use.

Keywords: sensors, networks, monitoring, closed system container, wireless monitoring ___________________________________________

102. Mass Production of Metal Oxide Nanowires Ezra L Clark*(1), Jeong H Kim(1), Vivekanand Kumar(2), Mahendra K Sunkara(2) (1)Advanced Energy Materials, (2)University of Louisville

Nanowires are beginning to find applications in several fields, such as lithium‐ion batteries and dye‐ sensitized solar cells. In all of these applications nanowires have shown improved properties over the currently used industrial materials. However, many of these applications require large quantities of nanowire powders with specific properties.

Therefore, bulk synthesis with controlled composition and morphology is a prerequisite for the commercialization of nanowire‐based technologies. Various methods have already been discovered to synthesize nanowires; however, due to substrate limitations most are limited to producing only a few milligrams per batch. The ideal method of large‐scale nanowire synthesis is in the gas‐phase, wherein the reacted species are quickly swept away from the reaction zone and there is no substrate limitation on the quantity of material produced. We recently designed, built,

grid especially during times of excessive heat. In order to help control these random anomalous peak loads, we have developed a system which will give electrical utility providers the ability to control AC units on both residential and commercial units.

Using wireless communication systems already in place, an integrated switching unit on the AC unit and algorithms to model multiple environmental conditions, our system is able to shift and reshape peak electrical loads on the power grid. The distribution strategy is targeted primarily to power producers. Incentives by the large power production companies could be passed along to sub‐users of the system to increase interest in the system. Our system uses resources available through various OEMs and mature switching technology which reduces overall risk, however, the combination of these resources with new algorithms to predict peak load occurrences produces a system which is state‐of‐the‐art. This same switching technology has been integrated into a smart thermostat which allows for marketing to not only power utilities and producers, but home owners wishing to decrease their energy cost.

Keywords: smart switch, smart thermostat, AC cycling, peak load reduction ___________________________________________

101. Closed System Container Wireless Monitoring Ashok Kumar, Siddhartha Bhattacharyya, Patrick Garrity* Department of Computer Science, Kentucky State Univerity

Wireless sensor technology (WST) involves a collection of specialized sensors designed to remotely monitor and collect information on an important product or material found in a specific location or space. For example, WST may be employed for monitoring any “closed system” container of liquid (with or without free headspace), like the contents of a barrel of fermenting bourbon. The use of WST allows for immediate (real‐time) monitoring of important 85

POSTER ABSTRACTS

Flexural tests are carried out under 4‐point bending on several small scale wide flange beams. The study also introduces the novel ultra high modulus CFRP strip panels for strengthening of steel bridge girders. The strip panels eliminate the requirement for a splice plate while also increasing the load causing yield in the steel beam.

Keywords: composites, polymers, strengthening, steel beams ___________________________________________

104. Novel Reaction Purification Cartridges and Nanopalladium Pellets for the Chemical and Pharmaceutical Industries Bo Xu, Gerald B. Hammond* Department of Chemistry, University of Louisville

The overarching goals of our research are to reduce time/labor‐consuming practices in chemical synthesis, and spur new concepts in chemoselectivity using green materials, and recyclable catalysts. To this effect we have devised a porous polymer supported organic phase that functions as a ‘rigid solvent’ framework that eliminates tedious liquid‐liquid extraction practices and provides universal reaction clean‐up. This ‘rigid solvent’ can also host metal nanoparticles that will catalyze a reaction with more efficiency and with less waste than current technologies.

Keywords: energy efficiency, chemical reactions, catalysis ___________________________________________

105. Sustaining Our Seafood: Video on Reuse Technology for Fish Production Steven D. Mims*, Richard J. Onders, Michael Wilhelm Department of Aquaculture, Kentucky State University

Sustaining Our Seafood video provides information on the need for aquaculture in the United States to use sustainable practices to be competitive in the global markets. Imports of cheaper fish products

and tested a reactor of such a design, which can be easily modified and adjusted to synthesize nanowires of numerous metal oxide systems. The gas‐phase method of metal oxide nanowire synthesis using this reactor has already been demonstrated with 4 different metal systems: tin oxide (SnO2), zinc oxide (ZnO), alumina (Al2O3), Titania (TiO2). A production rate of 1 gram of zinc oxide nanowires every 5 minutes was also demonstrated using the reactor. This corresponds to a production rate in the range of 100 grams of nanowires per day on a continuous basis. Thus the results of this study are unique and promising for both the research and commercialization of nanowire‐based materials.

Keywords: nanowire, nanowires, nano, solar, lithium, lithium‐ion, materials, mass production, bulk ___________________________________________

103. Strengthening Steel Beams with Ultra High Modulus CFRP Laminates I.E. Harik*, N.A. Peiris, D. Thompson University of Kentucky

Research on the application of fiber reinforced polymer (FRP) composites to steel structures has been limited. Utilizing FRP material for the repair and rehabilitation of steel members has numerous benefits over the traditional methods of bolting or welding of steel plates. Carbon FRPs (CFRPs) have been preferred over other FRP material for strengthening of steel structures since CFRPs tend to posses higher stiffness. The emergence of high modulus CFRP plates, with an elastic modulus higher than that of steel, enables researchers to achieve substantial load transfer in steel beams before the steel yields. This research analytically and experimentally investigates the bond characteristics between ultra high modulus CFRP strengthened steel members and the flexural behavior of these members. A series of double strap joint tests, using both ultra high modulus and normal modulus CFRP laminates, are carried out to evaluate the development length of the bond.

86

POSTER ABSTRACTS

have been increasing into the US partly because of higher costs of domestic fish production. Capital expenditures for land, ponds and tanks or other facilities are some of the reasons for the higher costs in the US and directly affect the overall market prices for food fish. Novel and cost‐saving practices need to be incorporated to remain competitive. Reuse of existing facilities that can be retrofitted for aquaculture, such as decommissioned wastewater treatment plants, could be an option. Many are being needlessly demolished, when reusing them as fish hatcheries could save the community demolition costs, create new jobs and generate revenue. These old urban facilities could provide a reliable system for intensive fish culture and provide ready access to markets and lower transportation cost. Reuse of old wastewater facilities is a growing idea to use existing tanks, processed water effluent and other infrastructure components to raise fish as stockers for aquaculture production. Fish have been extensively analyzed for heavy metals, pesticides and other contaminants to provide assurance to the public of its food safety.

Keywords: aquaculture, reuse technology, paddlefish ___________________________________________

106. Implantable Intraocular Pressure Sensor J. Todd Hastings Department of Electrical and Computer Engineering, University of Kentucky. ___________________________________________

107. Targeted Therapy for Cancer Treatment Sham Kakar Department of Physiology and Biophysics, James Graham Brown Cancer Center, University of Louisville ___________________________________________

87

POSTER ABSTRACTS

88

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

Abdelrehim

Aly

Graduate Research Assistant

Abeyweera

Buddika

Graduate Student

Adkins

Danielle

Accounting Assistant

Akabua

Elom

Ph.D. candidate

Alphenaar

Bruce

Professor

Amrein

Jeff

Partner

Anderson

Justin

Intellectual Property Associate

Andrews

Rodney

Director

Artiushin

Sergey

Res. Assistant Professor

Bai

Lihui

Bailey

Sean

Assistant Professor

Baker

Andy

Public Administration Specialist

Baker

Chris

Director, Information Technology

Baksan

Bedri

Visiting Scholar

Balk

John

Associate Professor

Barach

Casey

VP of Entrepreneurship

Basak

Sayantini

Research Assistant

Basaran

Burak

Post Doctoral Scholar

Beech

Wayne

Information Manager

Behr

Kathy

Technology Transfer Officer

Bell

Alexander

Student

Bennett

Tom

Professor

Bezold

Maxwell

Research Assistant

University of Louisville University of Louisville Kentucky Science and Technology Corporation University of Louisville University of Louisville Commonwealth Leverage LLC Wisconsin Alumni Research Foundation University of Kentucky University of Kentucky University of Louisville University of Kentucky Northern Kentucky Area Development District Kentucky Science and Technology Corporation University of Kentucky University of Kentucky ezone / NKY Tri‐ED

89

Kentucky State University University of Kentucky University of Kentucky University of Louisville University of Louisville Bellarmine University University of Kentucky

EMAIL aly_saber@yahoo.com bkabey01@louisville.edu dadkins@kstc.com aeakab01@louisville.edu brucea@louisville.edu jeff.amrein@c‐leverage.com janderson@warf.org rodney.andrews@uky.edu scarti1@email.uky.edu lihui.bai@louisville.edu scbailey@engr.uky.edu andy.baker@nkadd.org

cbaker@kstc.com bbaksan@gmail.com balk@engr.uky.edu cbarach@nkyezone.org sayantini.basak@kysu.edu bbasaran@uky.edu wayne@uky.edu kathy.behr@louisville.edu adbell03@louisville.edu tom.bennett@bellarmine.edu max.bezold@gmail.com

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

University of Louisville Kentucky State University University of Louisville University of Kentucky

EMAIL

Bhatnagar

Aruni

Professor of Medicine

Bhattacharyya

Siddhartha

Associate Professor/ Interim chair

Biswas

Souvik

Graduate Student

Bosserman

Mary

Research Harvester

Brown

Vickie Yates

President and CEO

Nucleus Kentucky

vybrown@nucleusky.com

Buchanan

Robert

Professor and Associate Dean of Research

University of Louisville

rmbuch01@gwise.louisville.edu

Burklow

Cindy

COO

Naprogenix, Inc.

cindy_burklow@yahoo.com

Butterfield

Timothy

Assistant Professor

C. Mohandas

Janet

Post Doctoral Scholar

Cahall

Ben

Student

Cai

Chuanxi

Cain

Jon‐Michael

Calie

Pat

Professor

Campbell

Nan

Student

Carreon

Moises

Assistant Professor

Carrithers

Stephen

Vice President

Sequela

Clark

Ezra

Associate Research Engineer

Cleland

Dan

Graduate Student

Clements

Twyman

Kentucky Space

Cohn

Robert

Professor

Collins

Karen

Graduate Student

Collins

Herman

Advanced Energy Materials, LLC University of Kentucky Kentucky Science and Technology Corporation University of Louisville University of Louisville University of Kentucky

Compton

Jeff

Connolly

John

Program Manager, Kentucky Enterprise Fund

Information Technology Manager Director of Business Development Project Director 90

University of Kentucky University of Kentucky Morehead State University University of Louisville Kentucky Science and Technology Corporation Eastern Kentucky University Eastern Kentucky University University of Louisville

aruni@louisville.edu s.bhattacharyya@kysu.edu souvik_gre@yahoo.com mboss2@uky.edu

tbutte2@uky.edu janetcm1@gmail.com ben.cahall@gmail.com c0cai003@louisville.edu jmcain@kstc.com pat.calie@eku.edu lizbeth_campbell41@mymail.eku.e du macarr15@louisville.edu sequelasteve@yahoo.com ezra.lee.clark@gmail.com dan.cleland@uky.edu tclements@kentuckyspace.com rwcohn@louisville.edu karen.collins@insightbb.com herman@uky.edu

Boneal, Inc.

jcompton@boneal.com

University of

jwdc405@aol.com

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

EMAIL

Kentucky Cooper

Nigel

Cox

Nancy

Crain

Mark

Craven

Rolf

Creager

Mitch

Cui

Yinan

D;Angelo

Elisa

Dakshinamurthy

Raja

Davidson

Michael

Degen

Gary

Dickson

Craig

Dobrokhotov

Vladimir

Dolloff

Paul

Donev

Eugene

Dziubla

Thomas

Eames

Chad

Eaton

John

Ebersole

Jeffrey

Edeen

Marybeth

El‐Habbak

Mohamed

Erb

Daniel

Estrada

Rosendo

University of Louisville Associate Dean for University of Research Kentucky MNTC Manager ‐ KY University of NanoNET Co‐PI Louisville University of Associate Professor Kentucky Kentucky Science Director of Accounting and Technology Corporation University of Ph.D. candidate Louisville University of Associate Professor Kentucky Western Kentucky Professor University University of Post Doctoral Scholar Kentucky NanoMark Chief Medical Officer Therapeutics Western Kentucky Graduate Student University Western Kentucky Assistant Professor University East Kentucky Senior Engineer Power Cooperative University of Research Associate Kentucky University of Assistant Professor Kentucky Kentucky Cabinet Executive Staff Advisor for Economic Development Deputy Director, University of Brown Cancer Center Louisville Assoc. Dean for University of Research Kentucky Manager ‐ ISS National NASA Lab Office University of Graduate Student Kentucky Kentucky Science Kentucky Space and Technology Corporation University of Post Doctoral Fellow Louisville Professor

91

nigelcooper@louisville.edu ncox@uky.edu mark.crain@louisville.edu rolf.craven@uky.edu mcreager@kstc.com yinan.c@gmail.com edangelo@uky.edu rajalingam.dakshinamurthy@wku.e du mtdavi2@engr.uky.edu garydegen@msn.com craig.dickson@wku.edu vladimir.dobrokhotov@wku.edu paul.dolloff@ekpc.coop eugene.donev@uky.edu dziubla@engr.uky.edu mlabreveux@kstc.com eatonredox@aol.com jleber2@uky.edu marybeth.a.edeen@nasa.gov m.elhabbak@uky.edu derb@kentuckyspace.com r0estr01@louisville.edu

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

Evans

Joyce

Biomedical Scientist

Fawzy

Wafaa

Assistant Professor

Feldhoff

Pamela

Associate Vice President of Research

Ferrell

Blaine

Dean

Fisk

Courtney

Engineer Associate

Fitzpatrick

Don

General Manager Global Cisco Alliance

Fleming

Stephen

Vice President and Executive Director

Frederick

Eric

Graduate Research Assistant

Frigui

Hichem

Professor

Fulcher

Jared

Graduate Student

Fuller

Jason

Assistant Professor

Gandee

Jaclyn

Sr Environmental Engineer

Gao

Qingming

Graduate Student

Garrity

Patrick

Graduate Student

Ghabrial

Said

Professor

Ghasemi

Amirhossein

Ph.D. candidate

Gobin

Andrea

Assistant Professor

Graham

James

Greene

Robert

Grimes

Caleb

Student

Grothaus

Caitlin

Student Asst

Grulke

Eric

Associate Dean for Research and Graduate Studies

Guiton

Beth

Assistant Professor

Gutierrez

Julio

Post Doctoral Fellow

University of Kentucky Murray State University University of Louisville Western Kentucky University University of Kentucky IBM Georgia Tech Enterprise Innovation Institute University of Kentucky University of Louisville University of Kentucky Eastern Kentucky University Global Quality Corp.

University of Kentucky Kentucky State University University of Kentucky University of Kentucky University of Louisville University of Louisville University of Louisville Morehead State University University of Louisville

Professor and ECE Chair Professor, Dept.

Chairman, Director

University of Kentucky University of Kentucky University of Kentucky 92

EMAIL jevans1@uky.edu wafaa.fawzy@murraystate.edu smsimp01@louisville.edu blaine.ferrell@wku.edu courtney.fisk@uky.edu donfitz@us.ibm.com fleming@gatech.edu edfred2@uky.edu h.frigui@louisville.edu jared.fulcher@gmail.com jason.fuller@eku.edu jaclyn@gqc.com qing‐ming.gao@uky.edu patrick@patrickgarrity.com saghab00@uky.edu amirhossein.ghasemi@uky.edu andrea.gobin@louisville.edu jhgrah01@louisville.edu dr.bob.greene@gmail.com b.malphrus@moreheadstate.edu ccgrot01@gwise.louisville.edu egrulke@engr.uky.edu beth.guiton@uky.edu Gutierrez @uky.edu

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

Hackl

Stephanie

Technology Scout

Dow Corning

Hall

Jessica

Research Assistant

Hall

Stephen

Member

Hammond

Gb

President

Hanlin

Patia L.

Data Coordinator

Hardin

Jason

Senior College Grants Officer

Harik

Issam

Professor

Harless

Brandi

Concierge

Harmon

Robert

Chair

Harnett

Cindy

Assistant Professor

Harris

David

Owner

Harvey

Dean

Executive Director

Harwood

James

Assistant Professor

Hawkins

Charles

Professor

Haws

David

Post Doctoral Scholar

Hay

Jeffrey

Research Associate

Hedman

Tom

Founder, General Partner and C.S.O.

Heink

Philip

Principal

Hellmann

Anna

Undergraduate Researcher

Hinds

Bruce

Associate Professor

Hord

Kyle

Student

Hornbeck

Jeremy

Graduate Research Assistant

Hu

Frank

Intern

Huda

Gazi

Graduate Research Assistant

Hunt

Arthur

Professor

Western Kentucky University Stoll Keenon Ogden PLLC Rigid Solutions LLC University of Kentucky University of Kentucky University of Kentucky EntrePaducah University of Kentucky University of Louisville Haltere Lab University of Kentucky University of Kentucky Northern Kentucky University University of Kentucky University of Louisville Orthopeutics, L.P. Ascension Analytical University of Louisville University of Kentucky University of Louisville University of Louisville Advanced Dynamics Inc. University of Kentucky University of Kentucky 93

EMAIL s.hackl@dowcorning.com jessica.hall228@topper.wku.edu steve.hall@skofirm.com gb.hammond@louisville.edu phanl0@uky.edu jhardin@engr.uky.edu iharik@engr.uky.edu bharless@entrepaducah.com rharmon@uky.edu cindy.harnett@louisville.edu dharrisdvm@gmail.com harvey@uky.edu james.harwood@uky.edu hawkins@nku.edu tina@ms.uky.edu jeffrhay@gmail.com thedman@orthopeutics.com phil@ascensionanalytical.com mhperl01@gwise.louisville.edu bjhinds@engr.uky.edu kmhord01@gmail.com jbhorn02@louisville.edu zongyanghu@uky.edu sumit128@gmail.com aghunt00@uky.edu

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

Inanc

Tamer

Associate Professor

Jackson

Doug

Research Engineer

Jain

Mahendra

Jarro

Carlos

Jaynes

John

Jennings

Ben

Director, Venture Finance

Jerkins

Diana

National Program Leader

Jiang

Xu

Ph.D. candidate

Jiang

Jieyun

Post Doctoral Scholar

Johnson

Rick

Director, Technology and Commercialization EIR

Jortani

Saeed

Associate Professor

Kaestner

Rick

CEO

Kakar

Sham

Professor

Kaplan

Henry

Professor and Chair

Karaca

Haluk

Assistant Professor

Kessler

Bruce

Associate Dean

Kesterson

Abbe

Sr. Facilites Manager

Kielkopf

John

Professor

Kimel

Kris

President

King

Robert

President

Knapp

Charles

Professor Emeritus, CBME

Knapp

Liz

Program Manager

KSTC Vice President and KSEF Executive Director Graduate Research Assistant Asst. Director Sponsored Programs

University of Louisville University of Louisville Kentucky Science and Technology Corporation University of Kentucky University of Louisville Kentucky Science and Technology Corporation USDA‐NIFA

94

University of Kentucky University of Kentucky Kentucky Science and Technology Corporation University of Louisville Two Dimensional Instruments, LLC University of Louisville University of Louisville University of Kentucky Western Kentucky University University of Kentucky University of Louisville Kentucky Science and Technology Corporation KY Council on Postsecondary Education University of Kentucky Kentucky Science and Technology Corporation

EMAIL t.inanc@louisville.edu doug.jackson@louisville.edu mjain@kstc.com cjarro@gmail.com jhjayn01@gwise.louisville.edu bjennings@kstc.com djerkins@nifa.usda.gov xu.jiang@uky.edu jieyun.jiang2@uky.edu rjohnson@kstc.com tomcco01@louisville.edu rickk@e2di.com sskaka01@louisville.edu hank.kaplan@louisville.edu karaca@engr.uky.edu bruce.kessler@wku.edu abbe.kesterson@uky.edu kielkopf@louisville.edu kkimel@kstc.com

robert.king@ky.gov knapp@uky.edu lknapp@kstc.com

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

Kentucky State University University of Louisville University of Kentucky InFLaMed Inc. and Kotwall Bioconsulting, LLC University of Kentucky Kentucky State University

EMAIL

Kochhar

Ts

Professor of Biology

Kolli

Sowmya

Graduate Student

Kostas

Vladimir

Ph.D. candidate

Kotwal

Girish

President

Kucera

Barbara A

Associate Project Director

Kumar

Ashok

Professor

Kurzynske

Rick

Statewide Director

Labreveux

Maria

Kentucky Cabinet Executive Staff Advisor for Economic Development

mlabreveux@kstc.com

Lambert

Susan Carson

Owner

sclgeographer@gmail.com

Lane

Derek

Associate Professor

Lang

Joanne

Executive Vice President

Lederer

Paul

President and CEO

Leedy

Aleck

Assistant Professor

Lei

Xingjian

Graduate Student

Leontsev

Serhiy

Post Doctoral Scholar

Lhamon

Mike

VP of Engineering

Li

Wen

Graduate Research Assistant

Li

Xiangrui

Ph.D. candidate

Lian

Yongsheng

Assistant Professor

Linville

Linda

Livengood

Bryan

Loomis

James

Lu

Y. Charles

133

EarthWorks, LLC

Assistant Vice President Academic Affairs Senior Research Scientist Graduate Research Assistant

University of Kentucky Kentucky Science and Technology Corporation UltraTrace Detection, LLC Murray State University University of Kentucky University of Kentucky Two Dimensional Instruments, LLC Kentucky State University University of Kentucky University of Louisville KY Council on Postsecondary Education Topasol LLC University of Louisville University of Kentucky

Professor 95

tkochhar@gwmail.kysu.edu s0koll05@cardmail.louisville.edu usa_vk@yahoo.com gjkotw01@gmail.com bakuce2@uky.edu ashok.kumar@kysu.edu kurzynske@kyepscor.org

derek.lane@uky.edu jlang@kstc.com p.lederer1@att.net aleedy@murraystate.edu lxj.applicant@gmail.com leontsev@uky.edu mel@e2di.com wen.li@kysu.edu xiangruili@uky.edu yongshenglian@gmail.com linda.linville@ky.gov livengood@topasol.com jms.loomis@gmail.com chlu@engr.uky.edu

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

Lucas

Tom

Graduate Student

Lumpp

Janet

Co‐Director

Lumpp

James

Professor

Luo

Guangxiang

Professor

Lykins

Nicholas

Graduate Student

Maddox

Jeremy

Professor

Mahmoud

Ali

Mania

Robert

Marshall

Gary

Director

Martin

Nancy

Professor

Matthews

Jamie

Associate Professor

Mattingly

Bruce

Professor

McIntyre

Michael

Assistant Professor

McKenna

Curt

Micro‐fabrication Rsrch Techt

McNamara

Shamus

Assistant Professor

McNeil

Roger

Dean

Mehanna

Monica

Administrative Staff Officer

Mendes

Sergio

Associate Professor

Miles

Stephanie

Student

Miller

David

Student

Mims

Steven

Professor

Minton

Terry

CEO

Mirmira

Srini

Program Director

Mo

Yiqun

Post Doctoral Fellow

Graduate Research Assistant Professor of Physics and KSU Space Grant Director

University of Louisville University of Kentucky University of Kentucky University of Kentucky Kentucky State University Western Kentucky University University of Louisville Kentucky State University Eastern Kentucky University University of Louisville University of Kentucky Morehead State University University of Louisville University of Louisville University of Louisville Morehead State University University of Kentucky University of Louisville University of Louisville University of Louisville Kentucky State University Naprogenix, Inc. Advanced Research Projects Agency ‐ Energy University of Louisville

96

EMAIL tmluca01@louisville.edu jklumpp@engr.uky.edu jel@uky.edu gluo0@uky.edu nicholas.lykins@kysu.edu jeremy.maddox@wku.edu aly.helmi@gmail.com robert.mania@kysu.edu gary.marshall@eku.edu nancymartin@louisville.edu jmatthew@uky.edu b.mattin@morehead‐st.edu mmcintyre01@insightbb.com cpmcke01@louisville.edu shamus.mcnamara@louisville.edu r.mcneil@moreheadstate.edu mehanna@engr.uky.edu sbmend01@louisville.edu sdmile05@louisville.edu dmill08@louisville.edu steven.mims@kysu.edu tminton@naprogenix.com srinivas.mirmira@hq.doe.gov yiqun.mo@lousiville.edu

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

Moiseeva

Evgeniya

Graduate Student

Mooers

Ian

Director ‐ CEDET

Moore

Neil

IS Support Specialist

Moreno

Monica

Graduate Student

Moss

Kyle

Electrical Engineer

Mossey

Jeffrey W

Assistant Project Director

Murray

David

Student

Naber

John

Professor

Nantz

Michael

Professor

Nash

Warren

Director

Nee

Matthew

Professor

Nehru

Neha

Student

Newberry

Jim

Nguyen

Mai‐Dung

Oakes

Landon

Research Assistant

Oberlink

Anne

Scientist

O'Hair

Dan

Dean and Professor

O'Leary

Sean

Associate Vice President

Otieno

Tom

Associate Dean and Professor

Paidipally

Anoop Rao

Graduate Student

Palmisano

Anna

Competitive Grantsmanship

Panja

Biswajit

Assistant Professor

Parichehreh

Vahidreza

Patwardhan

Abhijit

INSTITUTION/COMPANY

University of Louisville Eastern Kentucky University University of Kentucky University of Louisville Western Kentucky University University of Kentucky University of Kentucky University of Louisville University of Louisville Lexington ICC Western Kentucky University University of Kentucky University of Kentucky University of Louisville Western Kentucky University

Executive‐in‐ Residence Graduate Research Assistant

NuForm Materials

Graduate Research Assistant Professor, CBME, University of Kentucky 97

University of Kentucky Kentucky Science and Technology Corporation Eastern Kentucky University Western Kentucky University Science and Technology Consultant Morehead State University University of Louisville University of Kentucky

EMAIL evmois01@louisville.edu ian.mooers@eku.edu neil@cs.uky.edu mamore01@louisville.edu kyle.moss@wku.edu epscor@uky.edu dave.murray@uky.edu john.naber@louisville.edu mhnant01@gwise.louisville.edu warren.nash@uky.edu matthew.nee@wku.edu neha.nehru@uky.edu cduncan@uky.edu dmnguy01@louisville.edu landon.oakes@gmail.com anne.oberlink@nuformmaterials.co m ohair@uky.edu soleary@kstc.com tom.otieno@eku.edu anooprao.paidipally443@wku.edu palmscience@verizon.net b.panja@morehead‐st.edu v0pari01@louisville.edu abhijit@uky.edu

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

University of Post Doctoral Scholar Kentucky Graduate Research University of Assistant Louisville Energy and Cabinet Secretary Environment Cabinet University of Graduate Student Louisville Interim Executive Vice University of President for Research Louisville Dean/AVP for Eastern Kentucky Research University Graduate Research University of Assistant Louisville University of Professor and Director Kentucky University of Graduate Student Kentucky Western Kentucky Assistant Professor University University of Professor Kentucky University of Post Doctoral Fellow Kentucky University of Post Doctoral Scholar Louisville Western Kentucky Professor University

Peiris

Abheetha

Pendyala

Chandrashekh ar

Peters

Leonard

Pharas

Kunal

Pierce Jr.

William M.

Pogatshnik

Jerry

Porter

Alex

Puleo

David

Pulla

Spandana

Quiton

Jonathan

Rankin

Stephen

Rao

Srinivasa

Rathfon

Jeremy

Rathnayake

Hemali

Ray

Denis

CEO

Rempfer

Bob

President

Rempfer

Debbie

Executive Assistant, KSEF

Rexroat

Jason

Research Assistant

Rickett

Shannon

Director of Commercialization

Ronald

Ken

Program Manager

Rose

Sheri

Partner

Rose

Tyler

Student

Rouch

Keith

Professor

Secat, Inc. Amazingly Creative Inc. Kentucky Science and Technology Corporation University of Kentucky National Institute for Hometown Security Kentucky Science and Technology Corporation Commonwealth Leverage LLC Morehead State University University of Kentucky 98

EMAIL abheetha@engr.uky.edu c.pendyala@gmail.com len.peters@ky.gov kunal.pharas@louisville.edu l0ward01@louisville.edu jerry.pogatshnik@eku.edu amport03@louisville.edu puleo@uky.edu spandan17@gmail.com jonathan.quiton@wku.edu srankin@engr.uky.edu ssrao1@uky.edu jeremy.rathfon@louisville.edu hemali.rathnayake@wku.edu dray@secat.net brempfer@amazinglycreative.com drempfer@kstc.com jason.rexroat@uky.edu srickett@thenihs.org

kronald@kstc.com sheri.rose@c‐leverage.com tgrose@gmail.com rouch@engr.uky.edu

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

University of Louisville University of Louisville University of Louisville Thomas More College Western Kentucky University University of Kentucky University of Louisville

EMAIL

Rouchka

Eric

Associate Professor

Roussel

Thomas

Research Engineer Scientist

Russell

Harry

Graduate Student

Ryle

Wes

Assistant Professor

Sahi

Shivendra

Professor

Salmon

Elizabeth

Graduate Student

Sanchez Galiano

Ana

Saxon

Heather

Schardein

Gregory

Research Assistant

Schardl

Christopher

Professor

Senousy

Yehya

Graduate Student

Servo

Jenny

President, Business Acceleration Program

Sethu

Palaniappan

Assistant Professor

Shafaei

Sara

Ph.D. candidate

Shapiro

Robert

Professor

Sharp

M Keith

Professor

Shen

Chi

Associate Professor

Shin

Hainsworth

Assistant Professor

Shindell

Rick

President

Singh

Ajay

Post Doctoral Scholar

Singh

Mahavir

Scientist

Singh

Aman

Senior Editor, Corporate Responsibility

Vault.com

asingh@vault.com

Smith

Kristel

Assistant Director ‐ ICC

Eastern Kentucky University

kristel.smith@eku.edu

Nanotechnology Research Coordinator Senior Information Specialist, Communications and Information Studies

University of Kentucky University of Kentucky University of Kentucky University of Louisville Dawn Breaker University of Louisville University of Louisville University of Kentucky University of Louisville Kentucky State University University of Kentucky Zyn Systems

99

University of Kentucky University of Louisville

eric.rouchka@louisville.edu tjrous02@gwise.louisville.edu bennyr502@gmail.com wesley.ryle@thomasmore.edu shiv.sahi@wku.edu elizabeth.salmon@uky.edu ana.sanchez@louisville.edu

heather.saxon@uky.edu

greg.schardein@gmail.com schardl@uky.edu ymseno01@louisville.edu jcservo@dawnbreaker.com p.sethu@louisville.edu sara_shafaei@yahoo.com rshap01@uky.edu keith.sharp@louisville.edu chi.shen@kysu.edu hy.shin@uky.edu rick@zyn.com ajay.singh@uky.edu m0sing04@louisville.edu

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

EMAIL

Smith

Tim

Director, Aviation Education

Smith

Penny

Owner

Smith

Suzanne

Snyder

Chad

Professor

Sobolewski

Elissa

DHS SBIR Program Director

Frankfort Independent Schools Key to Knowledge Training University of Kentucky Western Kentucky University Department of Homeland Security

Sostarich

Joe

CEO

MedX12

jsostarich@medx12.com

Sowell

Dewayne

Research Assistant

dewayne.sowell363@topper.wku.e du

Stephens‐Frazier

Mary

Director/Office of Sponsored Programs

Strachan

Doug

Assistant Professor

Stromberg

Arnold

Professor

Subramanian

Navaladian

Post Doctoral Scholar

Sumanasekera

Wasana

Assistant Professor

Sumanasekera

Gamini

Associate Professor

Sun

Qian

Research Assistant

Sunderam

Sridhar

Assistant Professor

Sunkara

Mahendra

Interim Director

Sunkara

Vasanthi

President and CEO

Tamiya

Shigeo

Assistant Professor

Tanaka

Keiko

Associate Professor

Tang

Ziyou

Student

Western Kentucky University Kentucky State University University of Kentucky University of Kentucky University of Kentucky Sullivan University College of Pharmacy University of Louisville University of Kentucky University of Kentucky University of Louisville Advanced Energy Materials, LLC University of Louisville University of Kentucky Murray State University

Tapolsky

Mary

Tibe

John

Tobin

Thomas

Director of Commercialization and Program Manageme Director, Enterprise Infrastructure and Networking Professor 100

tim@kiae.org smith.penny33@yahoo.com ssmith@engr.uky.edu chad.snyder@wku.edu elissa.sobolewski@dhs.gov

mary.stephensfrazier@kysu.edu doug.strachan@uky.edu stromberg@uky.edu navaladian@uky.edu wsumanasekera@sullivan.edu gusuma01@gwise.louisville.edu sunqian2006@gmail.com ssu223@uky.edu mahendra@louisville.edu vasanthi.sukara@gmail.com shigeo.tamiya@louisville.edu ktanaka@uky.edu tonytang1991@yahoo.com

Nucleus

mtapolsky@nucleusky.com

University of Kentucky

john.tibe@uky.edu

University of

ttobin@uky.edu

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

EMAIL

Kentucky College IT Coordinator, Communications and Information Studies Vice President for Research Clinical Chemistry Fellow

University of Kentucky

Tovstiadi

Konstantin

Tracy

James

Truscott

Steven

Unuakhalu

Mike

EPSCoR Coordinator

Urbina

Luis

Research Assistant

Valdes, Jr.

Roland

Professor

Van Lanen

Steven

Assistant Professor

Voor

Michael

CSO

University of Kentucky University of Louisville Kentucky State University Kentucky State University University of Louisville University of Kentucky Vivorte Inc.

Voor

Ruth

President and CEO

Vivorte, Inc.

rvoor2@yahoo.com

Walsh

Kevin

University of Louisville

walsh@louisville.edu

Wan

Rong

Wang

Eugenia

CEO

Wang

Siqi

Ph.D. candidate

Wang

Frank

President

Webb

Cathleen

Chemistry Dept. Head

Wehrle

John

Vice President of Finance and Human Resources

Welch

Karla

Assistant Professor

Wermeling

Daniel

President

White

David

Professor and Director

White

Jen

Assistant Professor

Whittemore

Scott

Scientific Director KSCIRC

Wiederkehr

Rodrigo

Post Doctoral Fellow

MNTC Director ‐ KY NanoNET Program Director Research Associate Senior

101

University of Louisville Advanced Genomic Technology, LLC University of Kentucky Green Technology Ltd Co. Western Kentucky University Kentucky Science and Technology Corporation University of Louisville Alcomed, Inc. Murray State University University of Kentucky University of Louisville University of Louisville

tovstiadi@uky.edu

jtracy@uky.edu smtrus02@louisville.edu mike.unuakhalu@kysu.edu urbinazarate@aol.com rvaldes@louisville.edu svanlanen@uky.edu mike.voor@louisville.edu

r0wan001@louisville.edu ewangagt@gmail.com swa222@uky.edu greensolarins@yahoo.com cathleen.webb@wku.edu jwehrle@kstc.com karla.welch@louisville.edu dwermel@uky.edu david.white@murraystate.edu jenawhite@uky.edu swhittemore@louisville.edu rswied02@gwise.louisville.edu

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

Wilhelm

Mickey

Dean

Williams

Stuart

Assistant Professor

Williams

Tent

Principal and DEO

Willis

Unique

Post Doctoral Scholar

Wilson

Stacy

Professor

Womble

Phil

Professor

Wrenn

Michele

Executive Assistant

Wright

Jeweli

Business Analyst

Wu

Lu

Graduate Student

Wu

Qingliu

graduate student

Xue

Han

Ph.D. candidate

Xue

Liping

Principal Scientist

Yaghouby

Farid

Graduate Student

Yan

Bangbo

Professor

Yang

Yugu

Graduate student

Yazdanpanah

Mehdi

CEO‐Founder

Yoshida

Ruriko

Yuan

Ling

Associate Professor

Zamborini

Francis

Professor

Zanewicz

James

Director

Zhan

Dongying

Postdoctoral Researcher

Zhang

Qunwei

Assistant Professor

Zhang

Xiaoyan

Predoctoral Student

Zhang

Yuchen

Student

102

University of Louisville University of Louisville Regional Technology Strategies Kentucky State University Western Kentucky University Western Kentucky University Wind Energy Corporation Kentucky Science and Technology Corporation University of Kentucky University of Kentucky University of Louisville Advanced Dynamics Inc. University of Kentucky Western Kentucky University University of Kentucky NaugaNeedles University of Kentucky University of Kentucky University of Louisville University of Louisville University of Kentucky University of Louisville University of Kentucky Murray State University

EMAIL mickey.wilhelm@louisville.edu stuart.williams@louisville.edu jtrent@rtsinc.org unique.willis@kysu.edu stacy.wilson@wku.edu phillip.womble@wku.edu mwrenn@windenergycorp.com jwright@kstc.com wlu3@uky.edu wql01_1@yahoo.com x0han004@louisville.edu xuelp2005@gmail.com f.yaghouby@uky.edu bangbo.yan@wku.edu yyangb@uky.edu mehdi@nauganeedles.com ruriko.yoshida@uky.edu lyuan3@uky.edu fpzamb01@louisville.edu krjohn04@louisville.edu dzh222@uky.edu qunwei.zhang@louisville.edu xzh225@uky.edu yzhang2@murraystate.edu

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

Zhang

Justin

Student

Zhou

Xuguo

Assistant Professor

Zhu

Shifeng

Post Doctoral Scholar

Zurada

Jacek

Professor

University of Louisville University of Kentucky University of Kentucky University of Louisville

The “List of Attendees” includes online registrations received by May 20, 2011.

103

EMAIL zmh021810@gmail.com xuguozhou@uky.edu Shifeng.Zhu@uky.edu jmzura02@louisville.edu

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

INSTITUTION/COMPANY

104

EMAIL

MENU

Continental Breakfast and Morning Break (available 8:00AM – 9:00 AM) Orange, Grapefruit and Tomato Juice Seasonal Sliced Fresh Fruit Assorted Muffins and Breakfast Breads Fresh Fruit Preserves and Butter Freshly‐brewed Thelma’s Signature Blend Coffee and Decaffeinated Coffee Hot Tea with Lemons

Galt House Banquet Lunch

Galt House Salad – An assortment of fresh greens with vegetables and tomatoes served with our homemade house and fat free French dressing Entrée (choice of one) Maple Balsamic Salmon – Roasted salmon laced with a maple infused Balsamic vinegar reduction served with pesto mashed potatoes Lasagna – A hearty vegetables, Italian seasoning, cheese and onion, layered between lasagna noodles and topped with zesty tomato sauce (Vegetarian) Dessert: Fruits De Saison – A medley of fresh seasonal fruit, including Red Grapes, Cantaloupe, Honeydew, Pineapple, and berries Freshly Brewed Regular and Decaffeinated Coffee, Sweet Tea, and Assortment of Hot Teas Rolls and Butter

Afternoon Break

Freshly Popped Buttery Popcorn Freshly Baked Assorted Cookies Iced Tea, Sweet Tea, Lemonade

105

KIEC 2011 NOTES

106

KIEC 2011 NOTES

107

KIEC 2011 NOTES

108

KIEC 2011 NOTES

109

KIEC 2011 NOTES

110

GALT HOUSE SUITE TOWER FLOOR PLANS Second Floor

Third Floor

111