Brochure - Neuromodulation Market - Forecasts to 2017

MD 1378 | 2012

NEUROMODULATION MARKET – [Spinal Cord Stimulation (SCS), Vagus Nerve Stimulation (VNS), Gastric Electrical Stimulation (GES), Deep Brain Stimulation (DBS), Sacral Nerve Stimulation (SNS) & Transcranial Magnetic Stimulation (TMS)]

– Forecasts to 2017 Report Description

Table of Contents List of Tables Sample Tables Related Reports About MarketsandMarkets

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MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

Report Description Key Take-Aways •

To define and measure the global neuromodulation devices market, which comprises of internal stimulation and external stimulation

•

To analyze the market by identifying various subsegments of the global neuromodulation devices market

•

To forecast the revenue of the global neuromodulation devices market and its various segments

•

To identify major market trends and factors driving or inhibiting the growth of the global neuromodulation devices market and its sub-segments

•

•

To analyze opportunities for stakeholders in the market by identifying high-growth segments

•

To forecast revenue of market segments with respect to four main geographies – North America, Europe, Asia, and Rest of the World (RoW)

•

To strategically profile key players and comprehensively analyze their recent developments, financials, and strategies

•

To track and analyze competitive developments in the global neuromodulation devices market

To strategically analyze each submarket with respect to individual growth trends and contribution to the overall global neuromodulation devices market

Report Description The neuromodulation market is expected to grow at a CAGR of 11.6% in the next five years primarily due to technical advances and patient-friendly techniques such as minimally invasive and non invasive. The market is expected to show promise in therapeutic areas, as it offers relief from chronic pain, incontinence, heart failure, headache, depression, and epilepsy.

Moreover, there are few modalities in clinical trials for newer applications, for instance deep brain stimulation for Alzhiemer’s and depression, and vagus nerve stimulation for heart failure.

The neuromodulation market is expected to reach $6.8 billion by 2017.

Parkinson’s in the U.S. alone. A wide pool of patients suffering from other conditions such as depression, stroke, anxiety disorders, lower back pain, urinary incontinence, and tremor are also an influential factor in triggering the market towards growth.

Treatment for tinnitus represents one of the emerging applications in this market. According to the American Tinnitus Association, about 50 million people suffer from the disease in the U.S. alone.

Major players in the market include Medtronic, Inc. (U.S.), Cyberonics, Inc. (U.S.), Boston Scientific Corp. (U.S.), St. Jude Medical, Inc. (U.S.), Enteromedics, Inc. (U.S.), Dynatronics Corp. (U.S.), and Neuronetics (U.S.). Emerging players include Functional Neuromodulation Ltd. (U.S.), MicroTransponder, Inc. (U.S.), Zynex Medical, Inc. (U.S.) and Neurotech SA – a Sorin Group Company (Belgium).

The neuromodulation devices market includes spinal cord stimulation (SCS), deep brain stimulation (DBS), vagus nerve stimulation (VNS), sacral nerve stimulation (SNS), gastric electrical stimulation (GES), and external stimulation devices such as transcranial magnetic stimulation (TMS) and transcutaneous electrical nerve stimulation (TENS).

Rapidly aging population and associated diseases like Alzheimer’s, epilepsy, spinal cord injury and Parkinson’s are the prime reasons for the growth of this market. According to the International Neurostimulation Society, about 40-50 million patients worldwide suffer from epilepsy and 1.5 million from

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MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

Report Description Markets Covered The global neuromodulation devices market has been segmented as below:

External Stimulation • By Modality

Internal Stimulation •

§

Transcranial Magnetic Stimulation (TMS)

§

Transcutaneous Electrical Nerve Stimulation (TENS)

By Modality §

Spinal Cord Stimulation (SCS)

By Geography

o Market by Application

•

North America

•

Failed Back Surgery Syndrome

§

U.S.

•

Chronic Pain

§

Canada

•

Ischemia

•

Others §

•

Deep Brain Stimulation (DBS)

o Market by Application

•

Europe §

EU5 (Germany, France, Italy, Spain, U.K.)

§

RoE (Rest of Europe)

Asia

•

Parkinson’s Disease

§

India

•

Alzheimer’s

§

China

•

Dystonia

§

Japan

•

Tremor

§

RoA (Rest of Asia)

•

Depression

•

Others (Chronic Pain & Post Operative Coma) §

•

Sacral Nerve Stimulation (SNS)

o Market by Application •

Urinary Incontinence

•

Fecal Incontinence

Rest of the World (RoW) §

MEA (Middle East & Africa)

§

LatAm (Latin America)

§

Pacific (Australia & New Zealand)

The report does not include: •

The neuromodulator or drug pumps

o Market by Application

•

Respiratory neurostimulation by laparoscopy

•

Epilepsy

•

Cochlear implants and cortical simulators

•

Others

§

§

Vagus Nerve Stimulation (VNS)

Gastric Electrical Stimulation (GES)

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MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

Report Description Research Methodology Market Size Global Neuromodulation Devices Market • A top-down approach was taken to calculate the total neuromodulation devices market and its sub-segments (SCS, DBS, VNS, SNS, GES & TMS) • Volume numbers were arrived at by dividing the total market by the average selling price of a device (ASP) for a particular year • The market numbers were subsequently validated by interviews with industry and domain experts.

Market Share Global Neuromodulation Devices Market

• The market share have been discussed on the basis of actual sales recorded by companies to the total market size • The market share of top players was confirmed from secondary and primary data

Key Data Points from Secondary Sources Market revenue

Market revenue of companies Qualitative information (market dynamics, market trends)

Company financials, magazines, journals, press releases, paid databases, and MnM data repository Annual reports, company websites, public databases, and MnM data repository

Company websites, annual reports, press releases, databases, and MnM data repository

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MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

Report Description Key Data Points from Primary Sources Parameter

Data Points

Global Spinal Cord Neuromodulation device market 2012

~50%

Global Deep Brain Stimulation Market 2012

~ 11%

Global Vagus nerve stimulation Market 2012

~8%

Global Sacral Nerve stimulation Market 2012

~7.5%

Global Transcranial Magnetic stimulation Market 2012

~ 1-2%

Global Transcutaneous Electrical stimulation Market 2012

~ 14%

Assumptions

Prices

The average selling price of neuromodulation device products is considered as same across all geographies

Stakeholders •

Neuromodulation device companies

•

Original equipment manufacturing companies

•

Medical device distributors

•

Healthcare service providers

•

Health insurance players

•

Research and consulting firm

•

Medical Research institutes

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MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

Table of Contents 1. Introduction 1.1 Key Take-aways 1.2 Report Description 1.3 Markets Covered 1.4 Research Methodology 1.4.1 Market size 1.4.2 Market share

16 16 16 18 20 20 20

1.4.3 Key data points from secondary sources 1.4.4 Key data points from primary sources 1.4.5 Assumptions 1.5 Stakeholders

20 21 21 21

2. Executive Summary

22

3. Market Overview

25

3.1 Introduction

26

3.2 Market Segmentation 3.3 Market Dynamics

27 29

3.3.1.5

Investments and funds – an impetus for market growth 3.4 Restraints 3.4.1.1 An unfavorable reimbursement scenario hinders market growth 3.4.1.2 Lack of trained professionals likely to hamper market growth 3.5 Market Share Analysis

3.3.1 Drivers 29 3.3.1.1 Increasing incidence of neurological disorders to spur market growth 29 3.3.1.2 Unprecedented global aging to fuel market growth 29 3.3.1.3 Strong product pipeline to propel the market 30 3.3.1.4 Expanded target applications and new indications are expected to stimulate growth of neuromodulation devices 30

4. Global Neuromodulation Market (Internal & External) 4.1 Introduction 4.2 Internal Stimulation 4.2.1 Spinal Cord Stimulation (SCS) Market 4.2.1.1 Major applications 4.2.1.1.1 Failed back surgery syndrome 4.2.1.1.2 Chronic pain 4.2.1.1.3 Ischemia 4.2.2 Deep Brain Stimulation (DBS) 4.2.2.1 Major applications 4.2.2.1.1 Parkinson’s disease 4.2.2.1.2 Dystonia 4.2.2.1.3 Tremor 4.2.2.1.4 Alzheimer’s

36 37 37 39 40 40 42 42 45 46 47 47

4.2.3 Sacral Nerve Stimulation (SNS) 4.2.3.1 Major applications 4.2.3.1.1 Urine incontinence 4.2.3.1.2 Fecal incontinence 4.2.4 Vagus Nerve Stimulation (VNS) 4.2.4.1 Major applications 4.2.4.1.1 Epilepsy 4.2.4.1.2 Others 4.2.5 Gastric Electrical Stimulation (GES) 4.3 External Stimulation 4.3.1 Transcutaneous Electrical Nerve Stimulation (TENS) 4.3.2 Transcranial Magnetic Stimulation (TMS)

48

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31 32 32 33 33

35 48 51 52 53 53 56 57 58 58 61 61 64

MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

Table of Contents 5. Geographic Analysis 5.1 Introduction 5.2 North America 5.3 Europe

68 69 72 80

5.4 Asia 5.5 Rest of The World

6. Competitive Landscape 6.1 Introduction 6.2 Agreements, Partnerships, Collaborations, Contracts & Joint Ventures 6.3 New Product Launch

106 106

6.4 Expansion 6.5 Other Developments 6.6 Approvals

108 110

7. Company Profiles (Overview, Financials, Products & Services, Strategy, & Developments)* 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 7.10

ANM Adaptive Neuromodulation Gmbh Biocontrol Medical, Ltd. Boston Scientific Corporation Cerbomed Gmbh Cyberonics, Inc. Endostim, Inc. Enteromedics, Inc. The Magstim Company Limited Medtronic, Inc. Neuronetics, Inc.

87 97

122 125 128 136 139 144 147 150 153 159

7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 7.19

Neuropace, Inc. Neurosigma, Inc. Nevro Corporation Rs Medical Spinal Modulation, Inc. St. Jude Medical Synapse Biomedical, Inc. Uroplasty, Inc. Zynex, Inc.

112 113 114

122 162 164 167 169 172 174 182 184 188

*Details on Financials, Product & Services, Strategy, and Developments might not be captured in case of unlisted companies.

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MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

List of Tables 1 2 3 4

Global Neuromodulation Market, by Procedure, 2010 - 2017 ($Million)

23

Global Neuromodulation Market, by Modality, 2010 - 2017 ($Million)

23

Spinal Cord Stimulation Market, by Geography, 2010 - 2017 ($Million)

38

Spinal Cord Stimulation Market Volume,

by Geography, 2010 - 2017 (No of Units)

22

Global Transcranial Magnetic Stimulation Market,

by Application, 2010 - 2017 ($Million) 67

23

Neuromodulation Devices Market, by Geography, 2010 - 2017 ($Million) 69

24

External Neuromodulation Devices Market,

by Geography, 2010 - 2017 ($Million)

70

Internal Neuromodulation Devices Market,

by Geography, 2010 - 2017 ($Million)

71

25 39

5

Global Spinal Cord Stimulation Market, by Application, 2010 - 2017 ($Million) 41

26

Global External Neuromodulation Market, by Modality, 2010 - 2017 ($Million) 71

6

Deep Brain Stimulation Market, by Geography, 2010 - 2017 ($Million)

27

Global External Neuromodulation Devices Market Volume, by Modality, 2010 - 2017 (No of Units) 72

44

7

Deep Brain Stimulation Market Volume, by Geography, 2010 - 2017 (No of Units) 45

28

North America: Neuromodulation Devices Market,

by Procedure, 2010 - 2017 ($Million) 73

8

Global Deep Brain Stimulation Market, by Application, 2010 - 2017 ($Million) 46

29

North America: Internal Neuromodulation Devices Market, by Modality, 2010 - 2017 ($Million) 74

9

Sacral Nerve Stimulation Market, by Geography, 2010 - 2017 ($Million)

30 50

Sacral Nerve Stimulation Market Volume,

by Geography, 2010 - 2017 (No of Units)

North America: Internal Neuromodulation Devices Market Volume, by Modality, 2010 - 2017 (No. of Units) 75

51

31

Global Sacral Nerve Stimulation Market,

by Application, 2010 - 2017 ($Million)

North America: External Neuromodulation Devices Market, by Modality, 2010 - 2017 ($Million) 75

52

32

Vagus Nerve Stimulation Market, by Geography, 2010 - 2017 ($Million)

55

North America: External Neuromodulation Devices Market Volume, by Modality, 2010 - 2017 (No. of Units) 76

33

North America: Spinal Cord Stimulation Market,

by Country, 2010 - 2017 ($Million)

76

North America: Deep Brain Stimulation Market,

by Country, 2010 - 2017 ($Million)

77

10 11 12 13 14

Vagus Nerve Stimulation Market Volume,

by Geography, 2010 - 2017 (No of Units) Global Vagus Nerve Stimulation Market,

by Application, 2010 - 2017 ($Million)

56 34 57

15

Gastric Electrical Stimulation Market, by Geography, 2010 - 2017 ($Million) 59

35

North America: Sacral Nerve Stimulation, by Country, 2010 - 2017 ($Million) 77

16

Gastric Electrical Stimulation Market Volume,

by Geography, 2010 - 2017 (No of Units)

36

North America: Vagus Nerve Stimulation Market,

by Country, 2010 - 2017 ($Million)

17

Global Gastric Electrical Stimulation Market,

by Application, 2010-2017 ($Million)

60

78

37

North America: Gastric Electrical Stimulation Market,

by Country, 2010 - 2017 ($Million) 78

61

18

Transcutaneous Electrical Nerve Stimulation Market,

by Geography, 2010 - 2017 ($Million) 63

38

North America: Transcranial Magnetic Stimulation Market, by Country, 2010 - 2017 ($Million) 79

19

Transcutaneous Electrical Nerve Stimulation Market Volume, by Geography, 2010 - 2017 (No of Units) 64

39

20

Transcranial Magnetic Stimulation Market,

by Geography, 2010 - 2017 ($Million)

North America: Transcutaneous Electrical Nerve Stimulation Market, by Country, 2010 - 2017 ($Million)

79

Europe: Neuromodulation Devices Market,

by Procedure, 2010 - 2017 ($Million)

81

21

65

40

Transcranial Magnetic Stimulation Market Volume,

by Geography, 2010 - 2017 (No of Units) 66

41

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Europe: Internal Neuromodulation Devices Market,

by Modality, 2010 - 2017 ($Million) 81

MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

List of Tables 42

Europe: Internal Neuromodulation Devices Market Volume, by Modality, 2010 - 2017 (No. of Units) 82

63

ROW: Internal Neuromodulation Devices Market,

by Modality, 2010 - 2017 ($Million) 98

43

Europe: External Neuromodulation Devices Market,

by Modality, 2010 - 2017 ($Million) 83

64

ROW: Internal Neuromodulation Devices Market Volume, by Modality, 2010 - 2017 (No. of Units)

44

Europe: External Neuromodulation Devices Market Volume, by Modality, 2010 - 2017 (No. of Units) 83

65

ROW: External Neuromodulation Devices Market,

by Modality, 2010 - 2017 ($Million) 99

45

Europe: Spinal Cord Stimulation Market, by Region, 2010 - 2017 ($Million) 84

66

ROW: External Neuromodulation Devices Market Volume, by Modality, 2010 - 2017 (No. of Units) 100

46

Europe: Deep Brain Stimulation Market, by Region, 2010 - 2017 ($Million) 84

67

ROW: Spinal Cord Stimulation Market, by Region, 2010 - 2017 ($Million) 100

47

Europe: Sacral Nerve Stimulation, by Region, 2010 - 2017 ($Million)

68

ROW: Deep Brain Stimulation Market, by Region, 2010 - 2017 ($Million) 101

Europe: Vagus Nerve Stimulation Market, by Region, 2010 - 2017 ($Million) 85

69

ROW: Sacral Nerve Stimulation, by Region, 2010 - 2017 ($Million)

Europe: Gastric Electrical Stimulation Market,

by Region, 2010 - 2017 ($Million)

70

ROW: Vagus Nerve Stimulation Market, by Region, 2010 - 2017 ($Million) 102

Europe: Transcranial Magnetic Stimulation Market,

by Region, 2010 - 2017 ($Million) 86

71

ROW: Gastric Electrical Stimulation Market,

by Region, 2010 - 2017 ($Million)

103

Europe: Transcutaneous Electrical Nerve Stimulation Market, by Region, 2010 - 2017 ($Million) 87

72

ROW: Transcranial Magnetic Stimulation Market,

by Region, 2010 - 2017 ($Million)

104

52

Asia: Neuromodulation Devices Market, by Procedure, 2010 - 2017 ($Million) 88

73

ROW: Transcutaneous Electrical Nerve Stimulation Market, by Region, 2010 - 2017 ($Million) 104

53

Asia: Internal Neuromodulation Devices Market,

by Modality, 2010 - 2017 ($Million)

74 89

Agreements, Partnerships, Collaborations, Contracts & Joint Ventures, 2010 - 2012 108

Asia: Internal Neuromodulation Devices Market Volume, by Modality, 2010 - 2017 (No. of Units)

75

New Product Launch, 2010 - 2012

110

90

76

Expansion, 2010 - 2012

112

Asia: External Neuromodulation Devices Market,

by Modality, 2010 - 2017 ($Million)

90

77

Other Developments, 2010 - 2012

113

Asia: External Neuromodulation Devices Market Volume, by Modality, 2010 - 2017 (No. of Units)

78

Approvals, 2010 - 2012

114

91

79

57

Asia: Spinal Cord Stimulation Market, by Country, 2010 - 2017 ($Million) 92

Boston Scientific Corporation: Total Revenue and R&D Expenditure, 2009 - 2011 ($Million)

129

80

58

Asia: Deep Brain Stimulation Market, by Country, 2010 - 2017 ($Million) 93

Boston Scientific Corporation: Total Revenue,

by Segments, 2009 - 2011 ($Million)

129

81

59

Asia: Sacral Nerve Stimulation, by Country, 2010 - 2017 ($Million)

Boston Scientific: Total Revenue, by Geography, 2009 - 2011 ($Million)

130

94

82

Asia: Transcranial Magnetic Stimulation Market,

by Country, 2010 - 2017 ($Million)

Cyberonics, Inc.: Total Revenue and R&D Expenditure,2009 - 2011 ($Million)

140

95

83

61

Asia: Transcutaneous Electrical Nerve Stimulation Market, by Country, 2010 - 2017 ($Million) 96

Cyberonics, Inc.: Total Revenue, by Geography, 2009 - 2011 ($Million)

140

84

62

ROW: Neuromodulation Devices Market,

by Procedure, 2010 - 2017 ($Million)

Medtronic, Inc.: Total Revenue and R&D Expenditure, 2009 - 2011 ($Million) 154

85

Medtronic, Inc: Total Revenue, by Segments, 2009 - 2011 ($Million)

48 49 50 51

54 55 56

60

85

86

97

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99

102

154

MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

List of Tables 86 87 88

Medtronic, Inc.: Total Revenue, by Geography, 2009 - 2011 ($Million)

155

91

St. Jude Medical, Inc: Total Revenue and R&D Expenditure, 2009 - 2011 ($Million)

175

St. Jude Medical, Inc: Total Revenue, by Segments, 2009 - 2011 ($Million) 175

89

St. Jude Medical, Inc: Total Revenue, by Geography, 2009 - 2011 ($Million) 176

90

Uroplasty, Inc.: Total Revenue and R&D Expenditure, 2010 - 2012 ($Million) 185

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Uroplasty, Inc.: Total Revenue, by Geography, 2010 - 2012 ($Million)

185

92

Zynex, Inc.: Total Revenue and R&D Expenditure, 2009 - 2011 ($Million) 189

93

Zynex, Inc.: Total Revenue, by Segments, 2009 - 2011 ($Million)

189

MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

List of Figures 1

Neuromodulation Market Segmentation

28

2

Market Dynamics

32

3

Neuromodulation Market Share Analysis,

by Revenue, 2011

34

4

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Key Growth Strategies, 2010 - 2012

107

MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

Sample Tables Table

Global Neuromodulation Market, By Procedure, 2010 – 2017 ($Million)

Procedure

2010

2011

Total Table

2017

CAGR% (2012-2017)

2017

CAGR% (2012-2017)

s e l b a T e l p m

Internal Stimulation External Stimulation

2012

Sa

Spinal Cord Stimulation Market, By Geography, 2010 – 2017 ($Million)

Region

2010

2011

2012

s e l b a T e l p m

North America Europe

Sa

Asia RoW Total Table

Global Spinal Cord Stimulation Market, By Application, 2010 – 2017 ($Million)

Application Chronic Pain FBSS Ischemic Pain Others

2010

2011

2012

2017

CAGR% (2012-2017)

s e l b a T e l p Sam

Total

Table

Deep Brain Stimulation Market Volume, By Geography, 2010-2017 (No of Units)

Region

2010

2011

s e l b a T e l p m

North America Europe Asia RoW

2012

Sa

Total

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2017

CAGR% (2012-2017)

MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

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MD 1378 | 2012

Neuromodulation Market – Forecasts to 2017

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