May 2010
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Moving off the weight loss plateau HEALTH LINE BRIEFS
Avoiding Summer’s Health Woes
Simple changes you can make today to look better now and in the long term.
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Non-Melanoma Skin Cancers in the Millions and Rising
FDA Is Looking Into Claims About New Genetic Test Kit
Numbers have grown steadily since the 1990s; baby boomer epidemic predicted
• American Kids More Obese Than Previously Thought Mar 19, 2010Extreme obesity in U.S. kids is even worse than previously thought, researchers say. Kids are at higher risk of serious health problems as a result of being so overweight. The new study found more than 6 percent of kids were obese, while previous federal studies had it at only 3.8 percent. Far more boys than girls were obese, researchers report in the Journal of Pediatrics. The study examined 700,000 children and teens in California, a large study size.
• Smokers Who Quit Show Healthier Arteries Quitting smoking can buy more time against heart disease.A year after kicking the habit, smokers' arteries reversed the early stages of heart disease. The first large study to examine smokers' risk for heart disease was published in the Journal of the American College of Cardiology. Researchers in the study saw an improvement in artery function even though smokers gained an average of 9 pounds after they quit.Often, smokers lose the extra pounds after they get used to not smoking. The study gave 1,500 smokers five methods to quit and doctors saw a 1 percent improvement in artery function."That may not sound like much," but research shows that translates to a 14 percent lower risk of developing heart disease, Dr. James Stein, lead researcher, said. .
• Expecting? Get Active The American Congress of Obstetricians and Gynecologists recommend that pregnant women exercise for 30 or more minutes at a moderate intensity most days of the week. According to a study by the University of North Carolina at Chapel Hill, fewer than one in four women meet this goal. For otherwise healthy women, exercise during pregnancy has a number of benefits, including preventing gestational diabetes, helping control weight gain, and improving the expectant mother's mental health.
MATTHEW PERRONE,AP Business Writer WASHINGTON (AP) — The largest U.S. drugstore chain, Walgreen Co., said Wednesday it will hold off selling what was poised to be the first overthe-counter genetic test, after the Food and Drug Administration said the kit has not been proven effective. Pathway Genomics (HealthDay News) -- The incidence of nonas breast or prostate cancer. More people have announced Tuesday that its melanoma skin cancer has steadily increased had non-melanoma skin cancer than all other saliva swab would be on since the 1990s, making it by far the most cancers combined over the last 31 years, Walgreen's shelves later this common form of cancer, affecting more people according to the study. than all other cancers combined, two new studMost of those who had a non-melanoma skin month, offering millions of Americans the chance peek ies find. cancer had more than one, with the average into their genetic code for More than 2 million Americans on Medicare being 1.6, he noted. signs of inheritable diseases were treated for non-melanoma skin cancer in "This is only going to get worse," said Dr. 2006, up from 1.6 million in 1992, according Suephy Chen, an associate professor of derma- like Alzheimer's. But within 24 hours the comto one study. The other found that one in five tology at Emory University School of pany's plan was met with stiff 70-year-olds has been Medicine in Atlanta. "Our response from FDA regulators treated for non-melanoma population is aging. Those Researchers called nonwho said the products may run skin cancer. people who grew up in the melanoma skin cancer an 1970s and 1980s when there afoul of federal laws governing Researchers called nonmelanoma skin cancer an "epidemic" that is only going was not a big sun-protection medical tests. On Wednesday, the FDA posted a letter to "epidemic" that is only message out there are now t o g e t w o r s e Pathways online, indicating the going to get worse as all coming into their 50s and San Diego-based company those bathing beauties 60s and are starting to never submitted its product for and sun worshippers from the 1960s, 1970s develop skin cancers." federal review, a requirement and 1980s get older, and their cumulative sun While non-melanoma skin cancers are the for medical devices. exposure racks up. most common, melanoma is a serious worry. "These kits have not been "We are dealing with a problem that is not Though melanoma accounts for less than 5 proven safe, effective or accugoing away," said Dr. Howard Rogers, a derpercent of all skin cancers, it was expected to rate and patients could be makmatologist in Norwich, Conn., and lead author lead to an estimated 8,650 deaths in 2009, ing medical decisions based on of one of the studies. "The number has kept according to the American Cancer Society. data from a test that hasn't going up and up at a rate of 4.2 percent every In a third paper in the same journal, been validated by the FDA," year, on average, from 1992 to 2006," he said. researchers from the U.S. National Cancer The studies are published in the March issue Institute found survivors of one melanoma are said agency spokeswoman of the Archives of Dermatology. about nine times as likely as the general popu- Erica Jefferson, in an earlier statement Wednesday. The two types of non-melanoma skin cancer lation to develop a second melanoma. Walgreen said late are basal cell and squamous cell. While basal Wednesday that the Illinois cell carcinoma is slow-growing and rarely Skin Cancer Facts (skincancer.org) company had decided not to fatal, it can damage the surrounding tissue and • Skin cancer is the most common form of canbone if it's not caught early, causing disfigurecer in the United States. More than 3.5 million stock the tests until it has "further clarity" on the issue. ment when the cancer is removed. cases in two million people are diagnosed Pathway's test would have Squamous cell carcinoma is also rarely fatal, annually. been the first low-cost, massthough it can metastasize and spread to the • Each year there are more new cases of skin lymph nodes and other organs, Rogers said. cancer than the combined incidence of cancers marketed version of kits that screen for genes associated When caught early, squamous cell carcinomas of the breast, prostate, lung and colon. are also highly treatable. • One in five Americans will develop skin can- with diseases like prostate cancer, cystic fibrosis and diaIn the study by Rogers and colleagues, the cer in the course of a lifetime. researchers analyzed data from two Medicare • Basal cell carcinoma (BCC) is the most com- betes. A saliva collection kit plus databases and national surveys. They found the mon form of skin cancer; an estimated 2.8 milfull genetic analysis from total number of procedures to treat skin cancer lion BCCs are diagnosed annually in the Pathway was slated to cost in the Medicare population increased by nearly US.38 BCCs are rarely fatal, but can be highly about $275. 77 percent between 1992 and 2006. Between disfiguring if allowed to grow. Companies like 23andMe and 2002 and 2006 alone, skin cancer procedures • Squamous cell carcinoma (SCC) is the secNavigenics have sold similar increased by 16 percent. ond most common form of skin cancer. An estikits online for years, with In the second study, Dr. Robert Stern of Beth mated 700,000 cases are diagnosed each year prices ranging between $400 Israel Deaconess Medical Center and Harvard in the US,39 resulting in approximately 2,500 and $1,000. Medical School in Boston, developed a mathe- deaths. Those products have never matical model to estimate the prevalence of • Basal cell carcinoma and squamous cell carbeen reviewed by the FDA, non-melanoma skin cancer in the United cinoma are the two major forms of nonStates. melanoma skin cancer. Between 40 and 50 per- even though the agency has With about 13 million white non-Hispanic cent of Americans who live to age 65 will have the power to regulate all such laboratory-developed medical U.S. residents having been treated for at least either skin cancer at least once. tests. one non-melanoma skin cancer at the begin• Up to 90 percent of the visible changes comBut agency officials said ning of 2007, that means non-melanoma skin monly attributed to aging are caused by the sun. Wednesday that Pathway cancers have struck five times as many people Prevention and treatment ... page 2
E. coli Outbreak From Romaine Lettuce Widens
May 12, 2010 -- At least 30 people in four states have been sickened by a rare, virulent strain of E. coli in preshredded Romaine lettuce. Twelve of the victims have been hospitalized, three with kidney failure. There have
been no deaths to date. Some cases may have gone unreported because many labs do not test for the E. coli strain causing the outbreak. Michigan, Ohio, New York, and Tennessee have reported cases. The contaminated Romaine lettuce was sold by restaurants and by grocery/deli salad bars and processed by Freshway Foods in Sidney, Ohio. An unopened bag of Freshway shredded Romaine lettuce was found to carry the E. coli with the same genetic fingerprints as E. coli isolated from patients. Freshway has recalled all Romaine lettuce with a useby date of May 12 or earlier.
Freshway got the lettuce from a farm in Yuma, Ariz. Another lettuce distributor, Vaughan Foods, has also recalled lettuce from the same farm. However, no illnesses have yet been traced to lettuce distributed by Vaughan. Lettuce harvested from other areas does not appear to be associated with the outbreak, the FDA investigation suggests. The illnesses occurred between April 10 and April 26. Because of a lag time between the last reported illness and testing, it's possible new illnesses may still be occurring. People with E. coli infection usually get diarrhea and
abdominal cramps for two to eight days after eating a contaminated food. Most people recover within a week, but some cases are much more severe and last much longer. Some people may develop a form of kidney failure called hemolytic uremic syndrome or HUS. HUS tends to appear just as the diarrhea is getting better. Symptoms may include fever, abdominal pain, pale skin, fatigue, irritability, decreased urine output, unexplained bruises or bleeding from the nose and mouth, and swelling of the face, hands, feet, or body. Seek immediate medical care if these symptoms appear after several days of
crossed "sanctioned boundaries" for such products by seeking to sell its products in retail pharmacies. The agency's letter to Pathways, dated May 10, requests a response within 15 days. "We give them a chance to respond and tell us why do you think that this is, in fact, actually a legal product," said Dr. Alberto Gutierrez, the FDA's director of diagnostic testing. Pathways said in a statement it is communicating with the FDA and respects Walgreen's decision to hold off stocking the product. The proliferation of consumer-marketed genetic tests has troubled many public health officials and doctors who worry that the products are built on flimsy data. "The problem with all of these products is they're based on incomplete, invalidated data and we don't know what the impact on consumers will be," said Dr. Muin Khoury, director of the National Office of Public Health Genomics at the Centers for Disease Control and Prevention. The biology of how DNA variations actually lead to certain diseases is still poorly understood, although a number of public and private institutions have been racing to find answers. Khoury said that knowing a patient's medical history — including whether diabetes or heart disease run in their family — is actually more useful than current genetic testing. He and other experts worry that increasing prevalence of genomic tests could pressure doctors to order unnecessary tests and treatment. "I think it's going to be a headache for both primary care physicians and for consumers themselves who are going to get these reports back and not know what to do with the information," said Dr. Peter Kraft, professor of epidemiology at Harvard School of Public Health. But the prospect of millions of patients walking into their doctor's office with DNA test results may be unrealistic. A CDC survey found that just 22 percent of Americans were aware of genomic testing.
First lady releases child obesity recommendations page 7
Huntington's Disease Awareness Month recognized in May Seconds Count When Dealing with Stroke page 7