The McGill Tribune Vol. 18 Issue 12

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Redmen roll over at soccer nationals By T he M inh Lu o n g

The M cG ill R edm en’s reign as C anadian U n iv ersity so c ce r champions came to a disappointing end this week at Molson Stadium. A s h osts o f the CIA U N ational Tournament, the Redmen won one match and lost their remaining two to p la ce fourth in the six team event. After a som ewhat lacklustre season that saw them finish in third place in the Q uebec U niversity Soccer League, the Redmen played three strong games but were ulti­ mately done in by a lack o f finish­ ing touch and som e questionable calls. “W e weren’t outplayed in any o f the games this week,” said visi­ bly distraught M cG ill coach Pat Raimondo after Saturday’s loss in the bronze medal game. ‘T w o set plays knocked us out. It was just lik e the rest o f the sea so n , the b oun ces d idn ’t go our w ay lik e they did last year when we won the Nationals.” The Redmen were looking for a bronze medal and a measure o f revenge in Saturday’s affair with cro ss-to w n rival U n iv ersité du Q u éb ec à M ontréal C itad in s. UQAM , having defeated M cGill three times this season including a p la y o ff v ic to r y , has forg ed an intense rivalry with the Redmen in the process. UQAM defeated M cGill 1-0 to take third place in a match that was chippy at times. “It was difficult to get moti­ vated for this gam e, w e played here to defend our title,” said Rai­ mondo. “Nevertheless, I’m proud o f the way they cam e out today. They left it all out on the field.” After a conservative start to C o n tin u e d o n page 24

Catherine Farquharson

M c G ill's P e t e r B r y a n t b a t t l e s U Q A M 's N a s s o n T h e o s m y i n t h e b r o n z e m e d a l g a m e

McGill experiment blasts off with shuttle Discovery By Jo h n Salloum

When John Glenn went into orbit on the space shuttle Discovery, one of McGill’s science experiments w ent alon g with him . B acterial research experiments by Dr. James Coulton, a professor in the depart­ ment of microbiology and immunol­ ogy, were sent into space on Octo­ ber 29 as part of a study into design­ ing new 'smart drugs.' Coulton's research takes advan­ tage o f the micro gravity environ­ ment in space to create a medium through which to study proteins, the guardians at the entrances to bacteri­ al cells. "This is opening a whole new area of drug design. It is based on knowing what there is at the surface [of bacteria], rather than just throw­ ing things at the bugs and saying 'I hope you get killed by this,’" notes Coulton. “That is what w e have been doing over the last 25 to 3(f years...search ing for an tib iotics without really knowing the way they get inside [bacteria] or how they kill." Smart drug design is becoming a n ece ssity as bacteria b ecom e increasingly resistant to traditional

drug prescriptions. "They've been prescribed liber­ ally in the last four decades and bac­ teria are now resistant to many of the clinically useful antibiotics that are prescribed by p hysician s," explains the professor. "We have an interest in identi­ fying things at the surface of bacte­ ria, which are the pores or the chan­ nels across which these antibiotics pass," he continues. "A pore is made o f a protein, and the protein has a certain shape. It might have a hole through the middle, and this hole or channel is the way in which things can go from the outside o f the cell to the inside of the cell. So not just nutrients...go through these chan­ nels, but also antibiotics." Coulton's research seeks to map out these channels in the cell wall in detail, to determine what shape and size antibiotics must be, in order to pass through the channel to get inside and begin to kill it. "It turns out that [antibiotics] are less and less useful because bac­ teria now have ways to...chop them up," he notes. In order to map the entrance to the ce ll, the proteins need to be organized in a particular manner. A crystal grown over a protein can

identify this organizational frame­ work. "I’m using x-rays to identify the size, shape and organization o f a protein in a crystal," says Coulton "Gravity ca u ses p roblem s w ith growing crystals on earth because gravity causes the proteins to crash into each other. If you do it in micro gravity, where these collision forces aren't as great, it is possible that they will gently position themselves one beside the other, and the inter­ nal order created [may be] greater than that created on earth. "We got our preparations made, and w e took them to St. Hubert, w hich is the C anadian Space Agency palace on the South Shore." From there, the agency loaded it and other experiments into a special box designed for space travel, and trans­ ported the box to the K ennedy Space Centre in Florida. Coulton provided the shuttle crew with protein samples in one container, and a solution in another container which, when mixed with the proteins, create the crystals. "John Glenn and crew just have to turn the switch in order to mix the cocktails," Coulton says.

NICK a n d His s t a f ^ in v ite McGil s tu d e n ts to t h e n e w B r e a k fa s t a n d m o r e . B u r g e r s, S a n d w ic h e s e x p a n d e d R e s ta u r a n t k S t e a k s a n d o t h e r m e n u s e l e c t i o n s a v a i l a b l e * Open: P lace M ilton. S to p by, M o n 7 a .m . - 5 p .m . pick u p y o u r b re a k fa s t! — , | T u e s - F r i 7 a .m . - 7 p .m . c a rd a n d say S a t - S u n 8 a>m > 5 p . m .

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D ru g sm u g g lin g While preparations were being made for the shuttle's experiment, a more dow n-to-earth experim ent received some attention of its own. In conjunction with researchers in Konstanz, a German-Swiss border town, Coulton mapped the protein channel in high resolution detail here on earth. Coulton is quick to note, how­ ever, that this breakthrough does not invalidate the future findings of the shuttle mission. "The space mission may provide an even better [map­ ping] o f this protein than what we have achieved [on earth]." Coulton's detailed mapping of the protein channel may now enable researchers to design an antibiotic which cloaks itself in the size, shape and organization o f a nutrient that bacterial cells require such as iron. Coulton notes that this is effec­ tively a drug smuggling operation. "The bacterium is tricked into taking up [the hidden antibiotic] because it thinks that it is taking up iron." If an antibiotic which could immitate an iron nutrient were to be C o n tin u e d o n pag e 2

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