2022
McKelvey Engineering
RESEARCH BOLDLY
2022 | McKelvey Engineering
What did you make? Items and gadgets that have been made in the Spartan Light Metal Products Makerspace. Whoever said engineers weren't creative?
2022
JANUARY
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About | January
The image demonstrates localization of negatively charged plasmonic fluors (cyan) selectively on primary hippocampal neurons (red). The negatively charged nanoparticles specifically interface with mature neurons and completely avoid young neurons and glial cells (green). The heterogeneity in nanomaterials and neuronal cell interaction is attributed to the maturation stage of the neurons.
Prashant Gupta Doctoral student in the Department of Mechanical Engineering & Materials Science
Members of Soft Nanomaterials Lab in collaboration with Systems Neuroscience & Neuromorphic Engineering Lab have demonstrated for the first time how the maturation stage of the neurons plays crucial role on the nanomaterials interaction with neurons, which may provide new insight into non-genetic neuromodulation in the complex environment of large mammalian brain and possibly control the behavior of model organisms such as insects. Prashant Gupta is a member of Professor Srikanth Singamaneni's lab. g softnano.wustl.edu
2022
FEBRUARY
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About | February
The first image shows the total intensity of CFP tagged KCNQ1 channels. The second image shows only the KCNQ1 channels located on the plasma membrane through staining with an anti-HA fluorescent antibody. The third image is the merge of the two original channels and is used to calculate changes in the trafficking efficiency to the cell membrane for the KCNQ1 channel with the different calmodulin variants. Currently in the Silva lab, we are characterizing the changes to the KCNQ1 with the addition of specific calmodulin variants as calmodulin is a required auxiliary subunit for KCNQ1 function. Lucy Woodbury Doctoral student in the Department of Biomedical Engineering
Lucy Woodbury is a member of Associate Professor Jon Silva's lab. g silvalab.bme.wustl.edu
2022
MARCH
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About | March
The image shows the steps of TopoRoot, a method for computing hierarchy and fine-grained traits of maize roots from 3D imaging. A topologically simplified segmentation is first extracted from the image, followed by the computation of a geometric skeleton and hierarchy. Collaborative research with the Danforth Plant Science Center seeks to use geometric computing to help find the genetic basis behind root system architecture and the subsequent development of more productive crops.
Dan Zeng Doctoral student in the Department of Computer Science & Engineering
Dan Zeng is a member of Professor Tao Ju's lab and collaborates with Chris Topp's lab at Danforth Plant Science Center. g cs.wustl.edu/~taoju/
2022
APRIL
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About | April
These are images of collagen gels collected using reflectance quantitative polarization imaging (rQPLI). Each row represents a collagen gel of a different density. The grayscale (left column), Degree of Linear Polarization (middle column; strength of collagen fiber alignment), and Angle of Polarization (right column; orientation of collagen fibers) images give information about the microstructure of the tissue of interest.
Leanne Iannucci Doctoral student in the Department of Biomedical Engineering
The Musculoskeletal Soft Tissue Lab is interested in understanding polarized light-tissue interactions when performing rQPLI on tissues with differing extracellular matrix properties. Using this knowledge, rQPLI can then be used for real-time evaluation of collagen fiber alignment in dynamically loaded musculoskeletal soft tissues like tendons and ligaments. Leanne Iannucci is a member of Associate Professor Spencer Lake's lab in the Department of Mechanical Engineering & Materials Science. g lakelab.wustl.edu
2022
MAY
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About | May
The 6-dimensional images from pixOL depict Nile red molecules (NR, red bars) as they transiently bind to a spherical lipid bilayer (SLB, gray structures around the sphere). The top two rows show the orientations of NR (each line represents the long axis of the molecule) at different z-slices through the sphere (left to right). With cholesterol (aqua ellipses) present in the SLB, we observe that NR becomes more ordered and perpendicular to the sphere (top row); without cholesterol present to organize the membrane, NR exhibits various orientations (second row). Scale bar: 400 nm.
Tingting Wu Doctoral student in Imaging Science
Developed by the Lew Lab, the pixOL microscope enables super-resolution imaging of the 3D locations and 3D orientations of fluorescent molecules. Tingting Wu is a member of Assistant Professor Matthew Lew's lab in the Department of Electrical & Systems Engineering. g lewlab.wustl.edu
2022
JUNE
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About | June
The image compares two ridesharing algorithms simulated in the neighborhoods of Manhattan. Ridesharing algorithms are used to match passengers with vehicles to optimize some performance metrics, like delays incurred by passengers and total passenger requests served. Algorithm 2 prefers shorter trips, while algorithm 1 serves long-range passengers better.
Ashwin Kumar Doctoral student in the Department of Computer Science & Engineering
Algorithms can be black boxes that might have hidden biases or tradeoffs. Visualizing the output of ridesharing algorithms allows one to better understand the tradeoffs between efficiency (e.g., the number of requests that are matched) and fairness (e.g., the distribution of passengers that are matched). Algorithm 2 serves more passengers daily (higher profit), but at the cost of reduced service for the suburbs. Ashwin Kumar is a member of Associate Professor William Yeoh's lab. g sites.wustl.edu/wyeoh
2022
JULY
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About | July
The brilliantly gold image shows a carbon fiber sheet undergoing lithium ion intercalation. The carbon fibers display a blue, red and gold coloration with shiny metallic lithium deposits peppered across the matrix.
Rajeev Gopal Doctoral student in the Department of Energy, Environmental & Chemical Engineering
One of the current challenges plaguing solid-state batteries is their solid electrode-electrolyte interface which cannot effectively sustain high performance or long cycle life. Here a lithiated carbon fiber matrix is applied to a solid-electrolyte, promoting interface stability and mitigating potential dendritic growth which render solid-state cells unusable. Such solutions bring us one step closer toward a viable all-solid-state battery. Rajeev Gopal is a member of Assistant Professor Peng Bai's lab. g bailab.wustl.edu
2022
AUGUST
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About | August
The image shows the bubble entrapment process during droplet impact on a smooth heated hydrophobic surface, as well as its interfacial heat flux distribution. The entrapped bubble attaches to the surface, which reduces the total thermal energy transfer between droplet and substrate due to a reduced contact area and subsequently a limited conduction heat transfer. This finding enhances our understanding of the interplay of fluid dynamics, heat transfer, and phase change in transient multi-phase processes and their applications.
Junhui Li Doctoral student in the Department of Mechanical Engineering & Materials Science
Junhui Li is a member of Assistant Professor Patty Weisensee's lab. g sites.wustl.edu/weisensee
2022
SEPTEMBER
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About | September
The top image shows the fully-inkjet-printed perovskite lightemitting diodes (PeLEDs) on elastic substrate, which could be lit stably even under aggressive bending tests. The bottom one represents the prototype of a patterned PeLED display showing “WUSTL” characters.
Junyi Zhao Doctoral student in the Department of Electrical & Systems Engineering
By using inkjet printing as fabrication strategies, functional materials could be precisely deposited at the desired location with accurate volume control in picolitre-scale, which could satisfy the practical demands for high-resolution display panels composed of micro-scale lighting pixels and rapidly growing interests for customized pattern designs. The intrinsically flexible PeLEDs facilitate the adoption in the emerging foldable displays and smart wearables electronics. Junyi Zhao is a member of Assistant Professor Chuan Wang's lab. g wanggroup.wustl.edu
2022
OCTOBER
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About | October
The images show an unsteady vortex lattice simulation of a flapping wing, which mimics the flight of a bird. This research enables the rapid analysis of complex aerodynamic systems by simulating unsteady flows as sheets of ring vortices. The potential applications are wide-ranging and include wake-aircraft interactions, propeller flow fields and animal flight. Software has been made free and open source, which will further expand the impact of this method in the aerodynamic community.
Cameron Urban Undergraduate student majoring in mechanical engineering
Cameron Urban conducts research in Professor Ramesh Agarwal's lab in the Department of Mechanical Engineering & Materials Science.
2022
NOVEMBER
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About | November
The picture shows a cross section of the common tomato plant Solanum lycopersicum. Acoustic transduction by plants has been proposed a mechanism to "hear" nearby predators and prepare defenses. This image was used to create accurate finite element simulations to analyze the method by which acoustic radiation force could be sensed by the plant.
Ethan Hoppe Doctoral student in the Department of Mechanical Engineering & Materials Science
The Genin Lab studies interfaces and adhesion in nature, physiology and engineering. The current research focuses on interfaces between tissues at the attachment of tendon to bone, between cells in cardiac fibrosis, and between protein structures at the periphery of plant and animal cells. Ethan Hoppe conducts research in Professor Guy Genin's lab in the Department of Mechanical Engineering & Materials Science.
2022
DECEMBER
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About | December
The image represents a biomaterial-based hydrogel carrier for exogenous cell delivery to restore extracellular matrix (ECM) synthesis and tissue function in the degenerate intervertebral disc. Merge of aggrecan (green), total ECM synthesis (yellow), F-actin (red) and nuclei (blue) expressed in human nucleus pulposus cells encapsulated in 3D hydrogel after seven days of cell culture.
Deepanjali Patil Postdoctoral research associate in the Department of Biomedical Engineering
Research in the Setton Lab has studied cell-matrix interactions that regulate cellular synthesis and phenotype in intervertebral disc (IVD) pathology and translates this knowledge to develop biomaterials mimicking these environmental cues. Deepanjali Patil is a member of Professor Lori Setton's lab. g settonlab.wustl.edu