Research In Focus: Summer 2017

RESEARCH

IN FOCUS

Volume 3 What’s Inside Issue 4 2 Summer 2017 Faculty Focus Dr. Femi Ayeni

Dr. Susan Reid Department Chair Dr. Mohit Bhandari Associate Chair of Research Dr. Stephen Kelly Associate Chair of Education Cathy Turner Administrative Director Blake Dillon Communications Coordinator

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Research Highlights OSRS Retreat

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Spotlight on...

Newsworthy grants and appointments

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New Publications A long list of recent citations

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Save the Date!

MSA Awards & 50th Anniversary

Within the course of another academic year, we continue to look forward to the continued growth and success of our publications and grant funding, while continually working toward improving our brand of high-quality evidence-based surgery. Furthermore, we aspire to further develop our connectedness across divisions through our various initiatives.

Mohit Bhandari, MD, PhD, FRCSC Associate Chair, Research

FACULTY FOCUS

y Dr. Femi Ayeni With acknowledgment from our Chairs, we profile the outstanding research achievements of our great faculty

D

r. Olufemi (“Femi”) Ayeni is an Associate Professor of Orthopaedic Surgery at McMaster University. Dr Ayeni completed his Orthopaedic Surgery residency training at McMaster University. Following this, he completed two years of additional Sports Medicine Fellowship Training, first at the University of Ottawa/Carleton Sports Medicine Clinic and then at the Hospital for Special Surgery/Weill Cornell Medical Center in New York. While in New York, Dr. Ayeni was the Assistant Team Physician for the New Jersey Nets (NBA) and Iona College (NCAA). There, he also received dedicated training in Hip Arthroscopy. In his first year of

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practice, Dr. Ayeni spent a month in Europe as a Visiting Fellow in Hip Preservation and Hip Arthroscopic Surgery at the Schulthess Clinic in Zurich, Switzerland and at Orthopadische Chirurgie Munchen in Munich, Germany. He is currently the Medical Director for the Hamilton Tiger Cats football club (CFL) and VP of Research for the Arthroscopy Association of Canada. Dr. Ayeni’s clinical practice focuses on athletic injuries and non-arthritic conditions of the hip, knee, and shoulder in adolescents and adults. His research focus is on outcomes research in sports medicine and arthroscopic surgery. We sat down with Dr. Ayeni to discuss his progress, goals, and life in research.

Talk a little bit about your role as a clinical researcher.

With a clinical focus in sports medicine, my clinical activity drives my research. The connection between working surgically, clinically, and seeing patients everyday really drives my work as a researcher, and lets me focus on important questions — the answers to which could potentially change practice. I head up the academic side of the sports med-

researcher. He’s really helped tie me into what’s going on internationally. The leadership at Hamilton Health Sciences has also obviously helped me a lot.

Dr. William Orovan and Dr. Susan Reid have provided me with tons of support and advice on how to balance clinical practice with research, making sure each one is complimentary of the other. The reality is, everybody I interact with has impacted me in some way.

for that edge; they wonder how they can bounce back from injury or improve upon their previous year, and those kinds of questions ultimately trickle down to you as their physician. As such, you have to understand the literature, understand their craft, be up on the latest research, and be able to provide answers that are substantial to them. The great thing about this is that, all of the questions that pro athletes have, well, the regular person has them

“Being successful in research comes down to one thing: asking important questions, trying your best to answer them, providing information that may some day move practice forward, and, along that way, recognizing everybody that has contributed to your findings.” –Dr. Femi Ayeni icine part of our Orthopaedic department. Dr. Mohit Bhandari has supported me and helped me learn how to do method-based research. Gradually, I began to run my own investigations and pose my own questions. The role is always evolving; it’s always exciting.

You mentioned Dr. Bhandari as somebody who’s supported you. Who else has contributed to your development as a researcher along the way?

Yes, Mo played a very influential role in my developmental stages as a researcher. He gave me a thorough understanding of how to properly do research. My PHD supervisor Dr. Jon Karlsson out of the University of Gothenburg in Sweden has also been very pivotal in my career as a

With a résumé that includes impressive staff positions with big sports teams like the NBA’s New Jersey Nets, how did you eventually find yourself branching into research?

First of all, I played sports, so that’s how I gravitated toward sports medicine — my curiosity is intuitive. However, it’s my patients that really drive my research questions. When you’re dealing with athletes — especially those competing at the highest level — they come to you with questions that often require research to answer. ‘How can I optimize mobility?’ ‘How do I optimize performance?’ And, when dealing with athletes, the questions don’t stop — they become more frequent. Because everybody who competes is always looking

too. The weekend warrior might want to know which surgery will allow him to get back to playing squash with his friends; the high school student wants to get back to his or her routine as soon as possible. Athlete or not, you don’t have the luxury of guessing with patients — you have to have the facts or at least have ways in which you can obtain facts you don’t have, and that’s where research comes in.

Of your almost-2,000 PubMed citations, which one is the most memorable?

I would love to take credit for my citations, but every single one of them has been a team effort. I’m proud of them all, but my most memorable was a case report of a complication after a sur-

Research In Focus | June 2017

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gery. I thought to myself, “this is a two-page paper discussing a unique complication… should be a slam dunk for publication.” Well, the paper was accepted by the Journal of Bone and Joint Surgery (JBJS). I was elated by that — my first JBJS publication!

However, what I did not expect was they came back to me with 170 revisions. I couldn’t believe it! But, it made me realize that you can’t take anything for granted. When I finally saw it print, I was happy because I knew how much work went into it. This whole process taught me that, from concept to product, a lot of effort goes into publishing — even small case reports.

How do you define success in the context of research?

I would say being successful in research comes down to one thing: asking important questions, trying your best to answer them, providing informa-

tion that may some day move practice forward, and, along that way, recognizing everybody that has contributed to your findings. At the end of the day, if we’re able to move the ball a little bit forward — even an inch — then that’s a win. If everybody who helped feels like a contributor, then that’s a double-win.

What do you have planned, research-wise, for the future?

We’re researching to discover why younger individuals, particularly around the ages of 12 to 14, get into troubles with their hip joints. Something happens to adolescents around that age where they either develop pre-arthritic problems or they end up being just fine. So we want to know who develops the problems and why they do.

Is it genetics? Activity? Body mass index? Growth velocity?

There are all these contributing factors that we want to bet-

ter understand. So what we’re doing now, by way of peer-review funding, is collaborating with a group of surgeons and physicians from Brazil, Portugal, South Korea, the United States, and eventually the UK to study serial imaging of the hips of 12-year-old athletes and non-athletes. We’re tracking their activity and growth to determine what happens in the adolescent body that allows some individuals to become superstars who are pain-free while others experience problems. I think this will be an interesting way to screen and identify individuals who are getting in trouble with sports.

In baseball, they have pitch counts to promote longevity — perhaps this study will result in new limitations like that for minor sports. Kids are specializing in sports so early these days — they’re doing too much, too fast, too soon. This global prospective cohort will hopefully help promote good health in the young athlete.

Dr. Femi Ayeni with research mentor Dr. Mohit Bhandari.

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Research In Focus | June 2017

RESEARCH HIGHLIGHTS News, notes, and events from within McMaster’s surgical research division

OSRS RESEARCH RETREAT This past June, the Office of Surgical Research Services (OSRS), led by Dr. F. Farrokhyar, hosted a retreat for Department of Surgery Research Staff at the University Club of McMaster.

At the event, several distinguished surgical researchers presented on topics ranging from the values of conducting research in the field of surgery and the challenges researchers face to the success of research specific to McMaster’s Department of Surgery. All presentations were incredibly well received.

A major highlight from the retreat was a lively discussion regarding challenges in research.

The challenges, submitted by researchers anonymously to the OSRS prior to the retreat, were first discussed in small group sessions before they were eventually explored as part of a large group session. Some of the challenges discussed included developing a study protocol, networking, coordinating with the busy schedules of surgeons, abiding by

appropriate research rules and regulations, and a handful of others.

The OSRS recognizes the importance of bringing together research staff for networking opportunities and advancement discussion.

Dr. Farrokhyar and the OSRS team strive to support high-quality research across the Department of Surgery. And, based on the feedback they received from the Research Retreat, they believe that some topics need to be explored further. As such, the OSRS will continue to host Mini-Workshops on requested methodological and practical topics — follow the Department of Surgery on Twitter for more information on that!

@McMasterSurgery

Research In Focus | June 2017

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SPOTLIGHT ON...

Dr. Richard Whitlock

Dr. Richard Whitlock received the Mid-Career Investigator Award from the Heart and Stroke Foundation of Canada for his work as the lead Some marquee research highlights investigator on the CIHR-funded studies SIRS, LAAOS III, and TRICS from around the Department III. The award serves to strengthen of Surgery health research capacity in Ontario, in order to advance knowledge and innovation aimed at preventing cardiovascular/cerebrovascular disease (CCVD), reducing recurrence and complications, improving health outcomes (including quality of life), and decreasing the burden of CCVD-related illness and disability on individuals and society. The award provides salary support to highly qualified mid-career scientists who are within eight to 18 years of their first fulltime academic appointment. Congratulations to Dr. Whitlock on this amazing achievement!

Jonathan Bramson

Dr. Darren De SA Congratulations to Dr. Darren de SA (PGY5 Orthopaedic Surgery), who was awarded the 2017 Detweiler Travelling Fellowship and a 2017 Resident Leader Award.

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Research In Focus | June 2017

The Department of Surgery is proud to congratulate Jonathan Bramson on his new role as the Associate Dean of Research for McMaster’s Faculty of Health Sciences. Bramson, a professor in the Department of Pathology and Molecular Medicine, previously served as Assistant Dean of Research Infrastructure.

Some of Bramson’s initial objectives as Associate Dean of Research include creating new programs, developing stronger student programs, and building bridges that connect those at the applied end of medical sciences to those at the discovery end.

Dr. Ranil Sonnadara Dr. Ranil Sonnadara was recently awarded $84,976.92 from a 2017 Canarie Joint Security Project. The funding will be used to develop a suite of tools to give McMaster researchers detailed info about the traffic that is sent over Canada’s National Research and Education Network. The tools will help improve the effectiveness of the network (which is one of the ways that McMaster is connected to the outside world). The research will be conducted in collaboration with McMaster’s Computing Infrastructure Research Centre, of which Dr. Sonnadara is a Principal Investigator.

New Professors In 2017, the Department of Surgery promoted Drs. Michelle Ghert, Peter Lovrics, Yaron Shargall, and Marko Simunovic to Professor. The title is the highest rank that McMaster University can bestow, and it is conferred in recognition of outstanding achievement in education, scholarship, research, and clinical service. Congratulations to all four!

Dr. Kourosh Sabri Dr. Kourosh Sabri and the McMaster Paediatric Eye Research Group (McPERG) recently introduced their EYE-MAC vision screening project.

It is a multidisciplinary approach for vision screening in schools by trained community volunteers, including McMaster students from various programs. Volunteers are trained to carry out vision screening tests on children through theoretical and practical training modules. Once trained, the vision screeners enter schools and provide vision screening to children. Children who fail vision screening are connected with local partner optometrists for follow-up and vision loss prevention. At this point, EYEMAC has provided vision screening to children in five schools and have five more booked for this year. Local health awareness program Chit Chat Hearing recently donated a bus to the EYE-MAC project, which will provide Dr. Sabri and co. with a distraction-free, standardized environment for vision screening as well as the ability to reach children in more remote and rural areas. Thanks to Chit Chat Hearing, and congrats to EYEMAC on such an ambitious endeavour! For more information about the EYE-MAC vision screening project, please visit mcperg.com.

Research In Focus | June 2017

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Cardiac Surgery NEW PUBLICATIONS Some publication highlights from the 11 divisions of the Department of Surgery

Bartoszko J, Vorobeichik L, Jayarajah M, Karkouti K, Klein AA, Lamy A, Mazer CD, Murphy M, Richards T, Englesakis M, Myles PS, Wijeysundera DN. Defining clinically important perioperative blood loss and transfusion for the Standardised Endpoints for Perioperative Medicine (StEP) collaborative: a protocol for a scoping review. BMJ Open. 2017 Jun 30;7(6):e016743. doi: 10.1136/ bmjopen-2017-016743. IF-2.37 Writing Committee for the VISION Study Investigators., Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MTV, Srinathan SK, Walsh M, Abraham V, Pearse R, Wang CY, Sessler DI, Kurz A, Szczeklik W, Berwanger O, Villar JC, Malaga G, Garg AX, Chow CK, Ackland G, Patel A, Borges FK, Belley-Cote EP, Duceppe E, Spence J, Tandon V, Williams C, Sapsford RJ, Polanczyk CA, Tiboni M, Alonso-Coello P, Faruqui A, Heels-Ansdell D, Lamy A, Whitlock R, LeManach Y, Roshanov PS, McGillion M, Kavsak P, McQueen MJ, Thabane L, Rodseth RN, Buse GAL, Bhandari M, Garutti I, Jacka MJ, Schünemann HJ, Cortes OL, Coriat P, Dvirnik N, Botto F, Pettit S, Jaffe AS, Guyatt GH. Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30Day Mortality Among Patients Undergoing Noncardiac Surgery.

JAMA. 2017 Apr 25;317(16):16421651. IF-37.68

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Research In Focus | June 2017

Stevens LM, Noiseux N, Avezum A, Ayapati DR, Chen X, Lucchese FA, Cacheda H, Parvathaneni S, Ou Y, Lamy A; CORONARY Investigators.. Conversion after off-pump coronary artery bypass grafting: the CORONARY trial experience. Eur J Cardiothorac Surg.

2017 Mar 1;51(3):539-546. IF-2.80 Paikin JS, Hirsh J, Ginsberg JS, Weitz JI, Chan NC, Whitlock RP, Pare G, Eikelboom JW. Once versus twice daily aspirin after coronary bypass surgery: a randomized trial. J Thromb Haemost.

2017 May;15(5):889-896IF-5.56 Garg V, Peterson MD, Chu MW, Ouzounian M, MacArthur RG, Bozinovski J, El-Hamamsy I, Chu FV, Garg A, Hall J, Thorpe KE, Dhingra N, Teoh H, Marotta TR, Latter DA, Quan A, Mamdani M, Juni P, David Mazer C, Verma S. Axillary versus innominate artery cannulation for antegrade cerebral perfusion in aortic surgery: design of the Aortic Surgery Cerebral Protection Evaluation (ACE) CardioLink-3 randomised trial. BMJ Open. 2017 Jun 10;7(6):e014491. doi: 10.1136/bmjopen-2016-014491. IF- 2.37 Spence J, Belley-Côté E, Ma HK, Donald S, Centofanti J, Hussain S, Gupta S, Devereaux PJ, Whitlock R. Efficacy and safety of inhaled anaesthetic for postoperative sedation during mechanical ventilation in adult cardiac surgery patients: a systematic review and meta-analysis. Br J Anaesth. 2017 May 1;118(5):658-669. doi: 10.1093/ bja/aex087. IF-5.61

Al Otaibi A, Gupta S, Belley-Cote EP, Alsagheir A, Spence J, Parry D, Whitlock RP. Mini-thoracotomy vs. conventional sternotomy mitral valve surgery: a systematic review and meta-analysis. J Cardiovasc Surg (Torino). 2017 Jun;58(3):489496. IF-1.63

Belley-Côté EP, Jaffer I, Lamy A, Whitlock RP. Cost effectiveness of LAA closure in patients with AF and contraindications to warfarin: comment. Europace. 2017 May 1;19(5):882. IF-4.02

Chan V, Chu MWA, LeongPoi H, Latter DA, Hall J, Thorpe KE, de Varennes BE, Quan A, Tsang W, Dhingra N, Yared K, Teoh H, Chu FV, Chan KL, Mesana TG, Connelly KA, Ruel M, Jüni P, Mazer CD, Verma S. Randomised trial of mitral valve repair with leaflet resection versus leaflet preservation on functional mitral stenosis (The CAMRA CardioLink-2 Trial). BMJ Open.

2017 May 30;7(5):e015032. doi: 10.1136/bmjopen-2016-015032. IF-2.37

Liu J, Marcaccio MJ, Young JE, Aziz T, Wat J, Asa SL. Pancreatic Struma with Papillary Thyroid Carcinoma: a Diagnostic Dilemma. Endocr Pathol. 2017 Mar;28(1):91-94. IF-1.81

Thériault S, Whitlock R, Raman K, Vincent J, Yusuf S, Paré G. Gene Expression Profiles for the Identification of Prevalent Atrial Fibrillation.

J Am Heart Assoc. 2017 Jun 30;6(7). pii: e006057. doi: 10.1161/JAHA.117.006057. IF-5.11 Belley-Côté EP, Lamy AR, Whitlock RP. Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Disease.

N Engl J Med. 2017 Mar 16;376(11):1087-8. IF-59.55

General Surgery

Coroneos CJ, Roth-Albin K, Rai AS, Rai AS, Voineskos SH, Brouwers MC, Avram R, Heller B. Barriers, beliefs and practice patterns for breast cancer reconstruction: A provincial survey. Breast. 2017 Apr;32:60-65. IF-2.74 Doumouras AG, Saleh F, Sharma AM, Anvari S, Gmora S, Anvari M, Hong D. Geographic and socioeconomic factors affecting delivery of bariatric surgery across high- and low-utilization healthcare systems. Br J Surg. 2017 Jun;104(7):891-897. IF-5.59

Honarmand K, Chetty K, Vanniyasingam T, Anvari M, Chetty VT. Type 2 diabetes remission rates 1-year post-Roux-en-Y gastric bypass and validation of the DiaRem score: the Ontario Bariatric Network experience.

Clin Obes. 2017 Jun;7(3):176182. IF-n/a Kang X, Hong D, Anvari M, Tiboni M, Amin N, Gmora S. Is Daily Low-Dose Aspirin Safe to Take Following Laparoscopic Roux-en-Y Gastric Bypass for Obesity Surgery? Obes Surg. 2017 May;27(5):1261-1265.

IF-3.34 Wong SG, Maida E, Harvey D, Wagner N, Sonnadara R, Amin N. Evaluation of a physiatrist-directed prehabilitation intervention in frail patients with colorectal cancer: a randomised pilot study protocol. BMJ Open. 2017 Jun 9;7(6):e015565. doi: 10.1136/ bmjopen-2016-015565. IF- 2.37

Neurosurgery

Nath S, Badhiwala JH, Alhazzani W, Nassiri F, Belley-Cote E, Koziarz A, Shoamanesh A, BanFung F, Cornacchi SD, Reedfield L, Oczkowski W, Sharma ijk M, Hodgson N, Goldsmith M, Sahlas D, Reddy K, FarrokhCH, McCready D, Gohla G, yar F, Singh S, Sharma S, ZytaBoylan C, Lovrics PJ Breast ruk N, Selim M, Almenawer SA. cancer recurrence following Atraumatic versus traumatic radioguided seed localization lumbar puncture needles: a sysand standard randomized con- tematic review and meta-analtrolled trial. Am J Surg. 2017 ysis protocol. BMJ Open. 2017 Apr;213(4):798-804. IF-2.40 Mar 31;7(3):e014478. IF-2.56

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Lam Shin Cheung V, Provias J, Cenic A. Plexiform schwannoma of the thoracolumbar spine a rare clinical entity - a case report. Br J Neurosurg. 2017 Apr;31(2):279-281. IF-.33 Manoranjan B, Dey AK, Wang X, Kuzyk A, Petticrew K, Carruthers C, Arnold I. Role of non-government organizations in engaging medical students in research. J Investig Med. 2017 Mar;65(3):709-716IF-2.08 Rempel J, Busse JW, Drew B, Reddy K, Cenic A, Kachur E, Murty N, Candelaria H, Moore AE, Riva JJ. Patients’ Attitudes Toward Non-Physician Screening of Low Back and Low Back-Related Leg Pain Complaints Referred for Surgical Assessment.

Spine (Phila Pa 1976). 2017 Mar;42(5):E288-E293.IF-2.44

Wang KW, Fleming A, Singh SK, Banfield L, de Souza RJ, Thabane L, Samaan MC. Evaluating overweight and obesity prevalence in survivors of childhood brain tumors: a systematic review protocol. Syst Rev. 2017 Mar 3;6(1):43. doi: 10.1186/ s13643-017-0439-1. IF-n/a Turgeon AF, Lauzier F, Zarychanski R, Fergusson DA, Léger C, McIntyre LA, Bernard F, Rigamonti A, Burns K, Griesdale DE, Green R, Scales DC, Meade MO, Savard M, Shemilt M, Paquet J, Gariépy JL, Lavoie A, Reddy K, Jichici D, Pagliarello G, Zygun D, Moore L; TBI-Prognosis Study Team and the Canadian Critical Care Trials Group.. Prognostication in critically ill patients with severe traumatic brain injury: the TBI-Prognosis multicentre feasibility study. BMJ Open. 2017 Apr 17;7(4):e013779. doi: 10.1136/bmjopen-2016-013779. IF-2.56

Wang KW, Souza RJ, Fleming A, Singh SK, Johnston DL, Zelcer SM, Rassekh SR, Burrow S, Scheinemann K, Thabane L, Samaan MC. Adiposity in childhood brain tumors: A report from the Canadian Study of Determinants of Endometabolic Health in Children (CanDECIDE Study). Sci Rep. 2017 Mar 22;7:45078. IF-5.22

Ophthalmology

Zagzoog N, Ra G, Koziarz A, Provias J, Sommer D, Almenawer SA, Reddy K. Metastatic Liposarcoma of the Skull Base: A Case Report and Review of Literature. Neurosurgery. 2017 Apr 1;80(4):219-223. IF-3.78

Bozzo A, Bali K, Evaniew N and Ghert M. Retractions in cancer research: a systematic survey. Research Integrity and Peer Review (2017) 2:5. May 12, 2017 DOI 10.1186/s41073-0170031-1 IF-n/a

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Research In Focus | June 2017

Sabri K, Easterbrook B, Wakeman B, Mehta V, Riyaz R. Elbow splinting as a method to increase patching compliance in amblyopia therapy. Eye (Lond).

2017 Mar;31(3):406-410. IF-1.71

Orthopaedics

Banga K, Memon M, Baisi L, de SA D, Asheesh Bedi, Ayeni OR Outcomes in surgical and conservative treatment of symptomatic non-traumatic shoulder labrum tears in the paediatric population: a systematic review Journal of ISAKOS DOI: 10.1136/ jisakos-2016-000122 Published 22 May 2017 IF-n/a Brignardello-Petersen R, Guyatt GH, Buchbinder R, Poolman RW, Schandelmaier S, Chang Y, Sadeghirad B, Evaniew N, Vandvik PO. Knee arthroscopy versus conservative management in patients with degenerative knee disease: a systematic review. BMJ Open. 2017 May 11;7(5):e016114. doi: 10.1136/ bmjopen-2017-016114. IF-2.56 Chomsky-Higgins K, Miclau TA, Mackechnie MC, Aguilar D, Avila JR, Dos Reis FB, Balmaseda R, Barquet A, Ceballos A, Contreras F, Escalante I, Elias N, Vincenti SI, Lozano C, Medina F, Merchan G, Segovia J, Guerado E, Quintero JE, Morshed S, Bhandari M, Miclau T 3rd. Barriers to Clinical Research in Latin America. Front Public Health. 2017 Apr 18;5:57. doi: 10.3389/fpubh.2017.00057. eCollection 2017. IF-2.11 Doshi P, Gopalan H, Sprague S, Pradhan C, Kulkarni S, Bhandari M. Incidence of infection following internal fixation of open and closed tibia fractures in India (INFINITI): a multi-centre observational cohort study.

BMC Musculoskelet Disord.

2017 Apr 14;18(1):156. IF-1.68

Ekhtiari S, Haldane CE, de Sa D, Simunovic N, Ayeni OR. Fluid Extravasation in Hip Arthroscopy: A Systematic Review. Arthroscopy.. 2017 Apr;33(4):873-880IF-3.29 Ekhtiari S, Kay J, de Sa D, Simunovic N, Musahl V, Peterson DC, Ayeni OR. What Makes a Successful Survey?

A Systematic Review of Surveys Used in Anterior Cruciate Ligament Reconstruction.

Arthroscopy. Arthroscopy. 2017 May;33(5):1072-1079.e3. IF-3.29 Franceschetti E, Torre G, Palumbo A, Papalia R, Karlsson J, Ayeni OR, Samuelsson K, Franceschi F. No difference between cemented and cementless total knee arthroplasty in young patients: a review of the evidence. Knee Surg Sports Traumatol Arthrosc. 2017 Jun;25(6):1749-1756. IF-2.90 Ghert M. CORR Insights®: Can We Estimate Short- and Intermediate-term Survival in Patients Undergoing Surgery for Metastatic Bone Disease?

Clin Orthop Relat Res. 2017 Apr;475(4):1262-1264. IF-1.44.

Glennie RA, Bailey CS, Tsai EC, Noonan VK, Rivers CS, Fourney DR, Ahn H, Kwon BK, Paquet J, Drew B, Fehlings MG, Attabib N, Christie SD, Finkelstein J, Hurlbert RJ, Parent S, Dvorak MF. An analysis of ideal and actual time to surgery after traumatic spinal cord injury in Canada. Spinal Cord. 2017 Jun;55(6):618-623. IF-1.54

Hartman J, Khanna V, Habib A, Farrokhyar F, Memon M, Adili A. Perioperative systemic glucocorticoids in total hip and knee arthroplasty: A systematic review of outcomes. J Orthop.

2017 Apr 12;14(2):294-301. doi: 10.1016/j.jor.2017.03.012. eCollection 2017 Jun. IF-1.15 Johal H, Bhandari M, Tornetta P 3rd. Cochrane in CORR ®: Intramedullary Nailing for Tibial Shaft Fractures in Adults (Review).

Clin Orthop Relat Res. 2017 Mar;475(3):585-591 IF-1.44 Khan M, Cheung AM, Khan AA. Drug-Related Adverse Events of Osteoporosis Therapy. Endocrinol Metab Clin North Am. 2017 Mar;46(1):181-192. IF-3.30 Kim TK, Phillips M, Bhandari M, Watson J, Malhotra R. What Differences in Morphologic Features of the Knee Exist Among Patients of Various Races? A Systematic Review. Clin Orthop Relat Res. 2017 Jan;475(1):170182. Erratum to: What Differences in Morphologic Features of the Knee Exist Among Patients of Various Races? A Systematic Review. Clin Orthop Relat Res. 2017 May;475(5):1507. IF-3.12 Lerman DM, Cable MG, Thornley P, Evaniew N, Slobogean GP, Bhandari M, Healey JH, Randall RL, Ghert M. Has the Level of Evidence of Podium Presentations at the Musculoskeletal Tumor Society Annual Meeting Changed Over Time?

Clin Orthop Relat Res. 2017 Mar;475(3):853-860. IF-1.44

Mehlman CT, Okike K, Bhandari M, Kocher MS. Potential Financial Conflict of Interest Among Physician Editorial Board Members of Orthopaedic Surgery Journals. J Bone Joint Surg Am. 2017 Mar 1;99(5):e19. IF-2.46 Osterhoff G, O’Hara NN, D’Cruz J, Sprague SA, Bansback N, Evaniew N, Slobogean GP. A Cost-Effectiveness Analysis of Reverse Total Shoulder Arthroplasty versus Hemiarthroplasty for the Management of Complex Proximal Humeral Fractures in the Elderly. Value Health. 2017 Mar;20(3):404-411. IF-3.82 Rendon JS, Swinton M, Bernthal N, Boffano M, Damron T, Evaniew N, Ferguson P, Galli Serra M, Hettwer W, McKay P, Miller B, Nystrom L, Parizzia W, Schneider P, Spiguel A, Vélez R, Weiss K, Zumárraga JP, Ghert M. Barriers and facilitators experienced in collaborative prospective research in orthopaedic oncology: A qualitative study. Bone Joint Res. 2017 May;6(5):307-314. IF-2.42 Sardana V, Burzynski JM, Khan M, Stone N, Weening BS, Zalzal PK. Long-term functional outcomes and knee alignment of computer-assisted navigated total knee arthroplasty. Musculoskelet Surg2017 Apr;101(1):37-43. IF-1.81 Zelle BA, Weathers MA, Fajardo RJ, Haghshenas V, Bhandari M. Publication Productivity of Orthopaedic Surgery Chairs. J Bone Joint Surg Am. 2017 Jun 21;99(12):e62. doi: 10.2106/JBJS.16.00587. IF-4.84 Research In Focus | June 2017

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Stone N, Sardana V, Missiuna P. Indications and Outcomes of Cell Saver in Adolescent Scoliosis Correction Surgery: A Systematic Review. Spine (Phila Pa 1976). 2017 Mar 15;42(6):E363-E370 IF-2.44 Wong NC, Allard CB, Dason S, Farrugia P, Bhandari M, Davies TO. Management of pelvic fracture-associated urethral injuries: A survey of Canadian urologists. Can Urol Assoc J. 2017 Mar-Apr;11(3-4):E74-E78. doi: 10.5489/cuaj.4154. IF-.87 Writing Committee for the VISION Study Investigators., Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MTV, Srinathan SK, Walsh M, Abraham V, Pearse R, Wang CY, Sessler DI, Kurz A, Szczeklik W, Berwanger O, Villar JC, Malaga G, Garg AX, Chow CK, Ackland G, Patel A, Borges FK, Belley-Cote EP, Duceppe E, Spence J, Tandon V, Williams C, Sapsford RJ, Polanczyk CA, Tiboni M, Alonso-Coello P, Faruqui A, Heels-Ansdell D, Lamy A, Whitlock R, LeManach Y, Roshanov PS, McGillion M, Kavsak P, McQueen MJ, Thabane L, Rodseth RN, Buse GAL, Bhandari M, Garutti I, Jacka MJ, SchĂźnemann HJ, Cortes OL, Coriat P, Dvirnik N, Botto F, Pettit S, Jaffe AS, Guyatt GH. Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery. JAMA. 2017 Apr 25;317(16):1642-1651. IF-37.68

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Research In Focus | June 2017

Zelle BA, Francisco BS, Bossmann JP, Fajardo RJ, Bhandari M. Spanish Translation, Cross-Cultural Adaptation, and Validation of the American Academy of Orthopaedic Surgeons Foot and Ankle Outcomes Questionnaire in Mexican-Americans With Traumatic Foot and Ankle Injuries. J Orthop Trauma. 2017 May;31(5):e158-e162. IF-.89

Otolaryngology VanDeCappelle C, Wong J, Buchanan IM, Korman B, Ricci C. Life-threatening lingual artery hemorrhage after cardiac surgery. Can J Anaesth. 2017 Mar;64(3):333-334 IF-.93 Wagner N, Fahim C, Dunn K, Reid D, Sonnadara R. Otolaryngology Residency Education: A Scoping Review on the Shift Towards Competency Based Medical Education. Clin Otolaryngol. 2017 Jun;42(3):564-572. IF-2.62 Zagzoog N, Ra G, Koziarz A, Provias J, Sommer D, Almenawer SA, Reddy K. Metastatic Liposarcoma of the Skull Base: A Case Report and Review of Literature. Neurosurgery. 2017 Apr 1;80(4):219223. IF-3.78

Paediatric Surgery Poenaru D, Pemberton J, Frankfurter C, Cameron BH, Stolk E. Establishing disability weights for congenital

pediatric surgical conditions: a multi-modal approach.

Popul Health Metr. 2017 Mar 4;15(1):8. doi: 10.1186/s12963017-0125-5. IF-2.76 Stagg H, Cameron BH, Ahmed N, Butler A, Jimenez-Rivera C, Yanchar NL, Martin SR, Emil S, Anthopoulos G, Schreiber RA, Laberge JM; Canadian Biliary Atresia Registry.Variability of diagnostic approach, surgical technique, and medical management for children with biliary atresia in Canada - Is it time for standardization? J Pediatr Surg.

2017 May;52(5):802-806. IF-1.73

Plastic Surgery Hatchell AC, Farrokhyar F, Choi M. The Misconception of Case-Control Studies in the Plastic Surgery Literature: A Literature Audit. Plast Reconstr Surg.

2017 Jun;139(6):1356e1363e. doi: 10.1097 PRS.0000000000003330. IF-3.78 Liu EH, Stone N, Alowami SO, Thoma A. Proximal Phalanx Osteoid Osteoma: A Case Report and Literature Review. Plast Reconstr Surg Glob Open. 2017 May 25;5(5):e1332. doi: 10.1097/ GOX.0000000000001332. eCollection 2017 May. IF-n/a Thoma A, Eaves FF 3rd.

To Get the Best Outcome, Choose the Best Outcome.

Aesthet Surg J. 2017 Jun 1;37(6):739-741. doi: 10.1093/ asj/sjx063. IF-2.50

Waltho D, Hatchell A, Thoma A. Gynecomastia Classification for Surgical Management: A Systematic Review and Novel Classification System. Plast Reconstr Surg. 2017 Mar;139(3):638e648e. IF-3.08

Thoracic Surgery Donahoe LL, de Valence M, Atenafu EG, Hanna WC, Waddell TK, Pierre AF, Yasufuku K, de Perrot M, Cypel M, Keshavjee S, Darling GE. High Risk for Thoracotomy but not Thoracoscopic Lobectomy. Ann Thorac Surg. 2017 Jun;103(6):17301735. IF-3.02 Vernon J, Hanna WC. Response to Screening for Brain Metastases in Resectable Non-Small Cell Lung Cancer. J Thorac Oncol. 2017 Mar;12(3):e22. IF-5.04

Urology Bansal RK, Tanguay S, Finelli A, Rendon R, Moore RB, Breau RH, Lacombe L, Black PC, Kawakami J, Drachenberg D, Pautler S, Saarela O, Liu Z, Jewett MAS, Kapoor A. Positive surgical margins during partial nephrectomy for renal cell carcinoma: Results from Canadian Kidney Cancer information system (CKCis) collaborative. Can Urol Assoc J. 2017 Jun;11(6):182-187. doi: 10.5489/ cuaj.4264. IF-.87

Braga LH, Rickard M, Farrokhyar F, Jegatheeswaran K, Brownrigg N, Li C, Bansal R, DeMaria J, Lorenzo AJ. Bladder Training Video Versus Standard Urotherapy for Bladder and Bowel Dysfunction: A Non-Inferiority Randomized Controlled Trial.

J Urol. 2017 Mar;197(3 Pt 2):877-884. IF-4.7 Braga LH, McGrath M, Farrokhyar F, Jegatheeswaran K, Lorenzo AJ. Associations of Initial Society for Fetal Urology Grades and Urinary Tract Dilation Risk Groups with Clinical Outcomes in Patients with Isolated Prenatal Hydronephrosis.

J Urol. 2017 Mar;197(3 Pt 2):831-837. IF-4.7 Braga LH, Jegatheeswaran K, McGrath M, Easterbrook B, Rickard M, DeMaria J, Lorenzo AJ. Cause and Effect versus Confounding: Is There a True Association between Caudal Blocks and Tubularized Incised Plate Repair Complications? J Urol. 2017 Mar;197(3 Pt 2):845-851. IF-4.7 Crawford ED, Schally AV, Pinthus JH, Block NL, Rick FG, Garnick MB, Eckel RH, Keane TE, Shore ND, Dahdal DN, Beveridge TJ, Marshall DC. The potential role of follicle-stimulating hormone in the cardiovascular, metabolic, skeletal, and cognitive effects associated with androgen deprivation therapy. Urol Oncol. 2017 May;35(5):183-191. IF-2.92

Duivenvoorden WCM, Hopmans SN, Austin RC, Pinthus JH. Endoplasmic reticulum protein ERp46 in prostate adenocarcinoma. Oncol Lett.

2017 May;13(5):3624-3630. doi: 10.3892/ol.2017.5908. IF-1.48 El Dib R, Gomaa H, Ortiz A, Politei J, Kapoor A, Barreto F. Enzyme replacement therapy for Anderson-Fabry disease: A complementary overview of a Cochrane publication through a linear regression and a pooled analysis of proportions from cohort studies. PLoS One. 2017 Mar 15;12(3):e0173358. doi: 10.1371/ journal.pone.0173358. eCollection 2017 Mar 15. IF-3.54 Lee T, Hoogenes J, Wright I, Matsumoto ED, Shayegan B. Utility of preoperative 3 Tesla pelvic phased-array multiparametric magnetic resonance imaging in prediction of extracapsular extension and seminal vesicle invasion of prostate cancer and its impact on surgical margin status: Experience at a Canadian academic tertiary care centre. Can Urol Assoc J. 2017 May;11(5):E174-E178. doi: 10.5489/cuaj.4211. IF-.866 Richard PO, Jewett MA, Tanguay S, Saarela O, Liu Z, Pouliot F, Kapoor A, Rendon R, Finelli A. Safety, reliability and accuracy of small renal tumor biopsies: Results of a multi-institution registry.

BJU Int. 2017 Apr;119(4):543549 IF-4.38 Research In Focus | June 2017

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Oake JS, Davies TO, Houle AM, Beiko D. Exploring the business of urology: Change management. Can Urol Assoc J. 2017 Jun;11(6): 163-166. doi: 10.5489/ cuaj.4525. IF-.87 Rickard M, Lorenzo AJ, Braga LH. Renal Parenchyma to Hydronephrosis Area Ratio (PHAR) as a Predictor of Future Surgical Intervention for Infants with High-Grade Prenatal Hydronephrosis.

Urology. 2017 Mar;101:85-89.

IF-2.18 Shayegan B, Pouliot F, So A, Fernandes J, Macri J. Testosterone monitoring for men with advanced prostate cancer: Review of current practices and a survey of Canadian physicians. Can Urol Assoc J. 2017 Jun;11(6):204209. doi: 10.5489/cuaj.

4539. IF-.87 Wong ECL, Kapoor A. Epidemiology of prostate and kidney cancer in the Aboriginal population of Canada: A systematic review. Can Urol Assoc J. 2017 May;11(5):E222-E232. doi: 10.5489/cuaj.4185. IF-.866 Wong NC, Allard CB, Dason S, Farrugia P, Bhandari M, Davies TO. Management of pelvic fracture-associated urethral injuries: A survey of Canadian urologists.Can Urol Assoc J. 2017 Mar-Apr;11(34):E74-E78. doi: 10.5489/ cuaj.4154. IF-.87

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Research In Focus | June 2017

TOTAL CITATIONS

BY DIVISION Complete to June 30, 2017 As captured by PubMed Cardiac Surgery: 25 General Surgery: 31 Neurosurgery: 20 Orthopaedic Surgery: 101 Ophthalmology: 6 Otolaryngology: 11 Paediatric Surgery: 5 Plastic Surgery: 14 Thoracic Surgery: 13 Urology: 54 Vascular Surgery: 3 EBSWG: 0 Other: 16 Total to date: 278 Resident authors: 36

SAVE THE DATE

Upcoming events from around the Department of Surgery

OCTOBER 5, 2017 @ THE SPICE FACTORY, HAMILTON

NOVEMBER 11, 2017 @ THE SHERATON HOTEL, HAMILTON Research In Focus | June 2017

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