MD Anderson Annual Report 2005-2006 by MD Anderson Cancer Center

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K n o w, C e l e b r a t e , B e l i e v e What makes M. D. Anderson remarkable is our people. Our faculty and staff — and our many dedicated volunteers and generous supporters — know, celebrate and believe in our mission to eliminate cancer. Such a strong commitment to a shared vision has led to major advances in the diagnosis, treatment and prevention of cancer, and ultimately has contributed to the overall decline of cancer deaths despite a growing and aging population. Still, cancer is the leading cause of death for Americans under the age of 85. This simply is not acceptable, and we continue to work hard to find better ways to treat and prevent the disease. For example, we are exploring the use of nanoparticles — so small that they are measured in billionths of a meter — to deliver therapy and imaging agents. We also are expanding our pioneering chemoprevention research and epidemiological, behavioral and health disparities studies aimed at improving our ability to assess individual risks for cancer among healthy people. In addition, we are developing and bringing to our patients the most advanced forms of radiation therapy and surgical instrumentation, which are helping our physicians perform safer, more effective and lessinvasive procedures. The pace of discovery has never been greater or more profound. I am proud that our faculty and staff provide the highest quality of care, conduct excellent research, train so many bright students and fellows and bring us closer to eliminating cancer.

John Mendelsohn, M.D. President

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Innovations in Patient Care

M I S S I O N : Pat i e n t

Care

As their research colleagues are working to develop therapeutic drugs on the molecular level, M. D. Anderson physicians also are using something bigger than genes and molecules to treat patients with cancer. They are using technology. In just one year, M. D. Anderson brought online the most advanced form of radiation therapy and surgical instrumentation, which will help physicians deliver safer, more efficient care and improve the outlook for patients. Protons â&#x20AC;&#x201D; tiny, but powerful

M. D. Andersonâ&#x20AC;&#x2122;s new Proton Therapy Center began treating its first patients in spring 2006. The most precise form of radiation therapy, proton therapy uses a pencil-beam nozzle for scanning the proton beam throughout a tumor. To date, it has proven most effective for treating cancers of the prostate, eye, lung, brain, head and neck, and cancers in children.

Each treatment room in the Proton Therapy Center contains a huge gantry, which rotates around the patient and directs the proton beam at the target with an accuracy of less than one millimeter. James Cox, M.D. (left), head of the Division of Radiation Oncology, says the use of protons to treat cancer is one of the key technological advances of his career.

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“With proton therapy, we’re able to increase doses of radiation, preserve healthy tissue and treat more patients much more successfully,” says James Cox, M.D., head of the Division of Radiation Oncology. Protons differ from traditional X-ray treatment because they deposit the highest dose of energy when they come to a stop at a target in the body, yet have a very low dose of energy when they enter, and have no dose at all beyond the target. In addition, patients don’t feel anything during proton therapy treatment, and because of the minimal effect on healthy tissues, they experience few, if any, side effects. “This differentiation gives radiation oncologists greater control and effectiveness in directing and depositing high levels of destructive energies at a tumor,” Cox says. “There’s a broad range of patients who will be treated with proton therapy. They’ll be selected very carefully, based on the criteria that their tumor needs a high dose and it’s close to sensitive normal organs.” However, conventional radiation therapy remains a proven and vital cancer treatment and most often will still be the preferred radiation treatment, adds Cox, who is grateful for the generous philanthropic support of the Proton Therapy Center, including commitments of $500,000 or more from The Baldwin Sanders Moore Family Fund, The Brown Foundation, Inc., and The Hamill Foundation.

A deluxe suite M. D. Anderson’s new BrainSuite offers one of the world’s most advanced technologies, integrating the latest surgical and diagnostic tools in one operating room. “It brings together in one place everything it takes to maximize our ability to remove a brain tumor,” says Raymond Sawaya, M.D., chair of the Department of Neurosurgery. The high-tech operating room combines intraoperative magnetic resonance imaging with image-guided surgical systems and data management technologies to give neurosurgeons better information during surgery for the safe and precise removal of brain tumors. This includes ceiling-mounted cameras that provide the surgeon with updated images on huge video display panels. “It’s another great tool to use in our battle against brain tumors,” according to Jeffrey Weinberg, M.D., assistant professor in the Department of Neurosurgery. “This technology helps surgeons home in on the tumor while avoiding critical brain structures, thus reducing the kinds of neurological deficits that lead to impaired quality of life.” Patients with large, deep-seated skull base tumors will benefit most from the precision offered by the BrainSuite. With the help of a $500,000 gift from Mr. and Mrs. William J. Dorè Sr., Sawaya says the BrainSuite will break new ground in brain tumor treatment and research. “This is a very smart, very well-designed system that will enable us to help many patients and increase our teaching and clinical research capabilities.”

Jeffrey Weinberg, M.D., directs M. D. Anderson’s BrainSuite, which integrates an intraoperative, highfield magnetic resonance imaging system into the operating room.

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Nursing Magn etism Having first earned the honor in 2001, M. D. Anderson once again received Magnet Recognition Program designation from the American Nurses Credentialing Center in 2006. M. D. Anderson is one of only 13 institutions in Texas to be certified. This recognition is held by fewer than 200 health organizations, The da Vinci robot has four arms: three instruments to grasp, lift, cut and sear tissue, and one for the camera.

hospitals and hospital systems nationwide. With more than 2,400 registered nurses composing more than 16 percent of M. D. Anderson’s total workforce, the institution has expanded its nursing corps in a time of national shortage.

Robotic hands In 2006, M. D. Anderson began MINTOS, or Minimally Invasive and New Technology in Oncologic Surgery. Led by Surena Matin, M.D., associate professor in the Department of Urology, the program’s first installation of technology was the da Vinci Robotic Surgical System. This new technology allows a robot to perform surgery while the surgeon sits in the same room at a remote console, guiding the robot’s actions. The console has an opening for the surgeon’s face to view the surgical field through three-dimensional imaging. At the console, the surgeon places his or her hands into loops — one for the thumb and one for the index finger. Then, as the surgeon’s human hands move, the very tiny robotic “hands” mimic the action on a smaller scale inside the patient. The robot, placed at the patient’s side, has four arms: three instruments to grasp, lift, cut and sear tissue, and one for the camera. Each arm is inserted in the patient through a small incision or port. Assistants stand by to change instruments on the arms and make adjustments throughout the procedure.

Barbara Summers, Ph.D., head of the Division of Nursing, says her team has established community partnerships, enhanced financial and educational incentives, offered a mentoring program and refined flexible scheduling to retain and attract nurses. Such strategies, she adds, have allowed the nursing force to keep pace in the last five years with a patient growth rate of 37 percent and patient participation in therapeutic clinical trials that has grown by more than 100 percent.

The robot can’t be programmed and requires that every surgical movement be performed with direct input from the surgeon. Advantages of the system for the surgeon include the three-dimensional images that the camera provides, along with seven degrees of movement and no risk of hand tremors. Patient benefits may include less risk of infection, blood loss, scarring and pain, as well as shorter hospital stays and recovery time. While the system initially will be used for urologic procedures, there are plans for its use in treating gynecologic, thoracic and head and neck cancers.

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U i h l e i n

Freedom From Cancer James Uihlein is a firm believer in M. D. Anderson. Two years ago the Longboat Key, Fla., resident was diagnosed with tongue cancer. At the recommendation of his doctor and friends in Texas, he soon found himself under the care of Randal Weber, M.D., chair of the Department of Head and Neck Surgery. Today, he is cancer-free and credits his positive outcome to the specialized, quality care he received from Weber and his team. “I came to believe in M. D. Anderson,” says Uihlein, who admits he knew little about cancer when he began his journey in 2004. “I quickly found out about M. D. Anderson, and I’m glad I did.” Uihlein moved to Houston temporarily to undergo six weeks of radiation therapy. Six months after treatment, a CT scan showed no cancer. Relief turned to gratitude, and Uihlein took the opportunity to “give back” by contributing $100,000 to Weber’s Head and Neck Priority Program. The money, Weber says, will help sup-

port a research nurse as well as numerous projects, including a Phase II clinical trial involving Iressa, a targeted agent that inhibits the epidermal growth factor receptor in squamous cell skin cancer. Uihlein says the contribution reflects his confidence in M. D. Anderson. “You just try to give back if you can,” he says. “Dr. Weber is a super guy. He spoke briefly to me about what he’s trying to do through his research, and I’m looking forward to hearing more.” — Sarah Watson

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Caring for the Children Described as a place “where kids rule, not cancer,” the Children’s Cancer Hospital at M. D. Anderson is much like the basketballs that often bounce around in the PediDome — it keeps going higher and, more often than not, makes the goal. With a more than 50-year history of outstanding patient care as a foundation, the Children’s Cancer Hospital has built on this solid base with a new name and logo and an enhanced team of physicians on staff to treat pediatric patients.

Physicians also are studying whether gene therapy increases immune responses to fight lung metastases, and if oral drugs used to target growth-promoting proteins in adult cancers can be used to treat pediatric osteosarcoma.

Childhood cancer is a rare disease, but because pediatric patients are treated under the larger umbrella of a comprehensive cancer center, translational protocols from adult treatments have an easier journey into the children’s side of cancer. Likewise, adults benefit from clinical trials tested in children. Because of the close partnership between the pediatric and adult services at M. D. Anderson, a successful leukemia protocol for high-risk pediatric patients is now being evaluated in adults.

Brain tumors are a target as well, with a Phase III combination trial comparing two treatment protocols for gliomas under way and a gene therapy approach for medulloblastoma under development.

Children benefit from unique protocols offered at M. D. Anderson, in addition to those that are sponsored by the national Children’s Oncology Group. Several protocols evaluating new therapies for osteosarcoma (bone cancer), for instance, are ongoing. With the promise of fewer side effects, aerosolized chemotherapy is being tested for treatment of osteosarcoma that has spread, or metastasized, to the lung.

Discoveries made in the laboratory also are helping to direct treatment. Identification of absolute lymphocyte count as a determinant of risk and survival for pediatric patients with leukemia, nonHodgkin’s lymphoma and Ewing’s sarcoma is a meaningful example. Based on this finding, an easy and affordable test now establishes whether a young patient should receive standard therapy or a more aggressive treatment. This sound, forward-thinking approach mixes well with the topdrawer care a young cancer patient receives at the Children’s Cancer Hospital. Add a dash of hope for good measure, and the winning goal of higher survival rates for pediatric cancer patients is a slam dunk.

Andrea Hayes-Jordan, M.D., performs a unique procedure that uses a warm solution containing anticancer drugs to bathe the abdominal tissue or organ containing the tumor in children.

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Setting New Standards of Care Clinical research has been a driving force for change in how cancer is managed today, and M. D. Anderson investigators are leading the charge. With its large patient base and outstanding research programs, M. D. Anderson is positioned to conduct all phases of a clinical trial and bring forth findings of promising new agents to be considered by the U.S. Food and Drug Administration, says Maurie Markman, M.D., vice president for clinical research. Three such drugs tested in M. D. Anderson-led multi-center trials have been approved by the FDA this past year. They include: • Taxotere, a common breast cancer drug, was approved for use in combination with chemotherapy to treat patients with advanced stomach cancer. The FDA based its decision on results from the TAX 325 study, the largest international Phase III clinical trial in previously untreated advanced stomach cancer, says Jaffer Ajani, M.D., study principal investigator and professor in the Department of Gastrointestinal Medical Oncology. • Cetuximab, a monoclonal antibody previously approved to treat advanced colorectal cancer, gained FDA approval for use in treating head and neck cancer. “For patients with locally or regionally advanced disease, cetuximab in combination with radiation therapy has demonstrated a clinically significant improvement in survival and locoregional control,” says radiation oncology professor Kie-Kian Ang, M.D., Ph.D., who coordinated the pivotal international trial. • Decitabine, called a major advance in the ongoing fight against myelodysplastic syndrome, or MDS, was approved as “a new treatment option pioneered at M. D. Anderson that can reduce or eliminate the need for frequent blood transfusions among patients with MDS,” says Hagop Kantarjian, M.D., study lead and chair of the Department of Leukemia. Results from a multi-center Phase III clinical trial demonstrated an overall response rate of 21 percent in MDS patients treated with decitabine. None of the responders required transfusions during this time, adds Kantarjian, clinical investigator for the decitabine clinical development program for MDS and acute myelogenous leukemia. “A great thing about M. D. Anderson is that our clinical investigators never stop,” Markman says. “When a new standard is set, they move to find something better, which may mean it’s more effective or as effective, but less toxic.”

The U.S. Food and Drug Administration’s approval of cetuximab in March 2006 for treating head and neck cancer was called “an important milestone” by Kie-Kian Ang, M.D., Ph.D. Cetuximab is the first FDA-approved new therapy for patients with these types of tumors in more than three decades.

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Drug Combo Increases Melanoma Survival If caught early, melanoma often can be treated successfully by removing the lesion, along with a portion of the surrounding tissue. The problem arises when melanoma spreads, or metastasizes, beyond its original site. Once the disease has migrated beyond the local lymph nodes, it’s difficult to treat and survival is low. By design, the pigment-producing cells in the skin are hardy with an elaborate DNA repair mechanism in place to protect the skin from ultraviolet light. This very resiliency increases melanoma cells’ ability to resist the effects of chemotherapy, making standard cancer treatments less than optimal. Although current therapies work in some patients, they have had a limited ability to fight metastatic melanoma in the majority of patients until now. Results of a Phase II study “are encouraging and point to a potentially more effective and less toxic therapy for treating metastatic disease,” says Wen-Jen Hwu, M.D., Ph.D., study lead investigator and professor in M. D. Anderson’s Department of Melanoma Medical Oncology. Hwu and her colleagues reported in the journal Cancer that temozolomide plus pegylated (long-acting) interferon-alpha-2b had significant antitumor activity in patients with stage IV metastatic melanoma. Separately, temozolomide and interferon-alpha-2b are active in melanoma, Hwu notes, but together — and with the right dose and treatment schedule — they become a force to be reckoned with. “At lower doses and for a longer period of time, we found that constant levels of both drugs can be maintained and provide a more sustained benefit,” Hwu says.

Wen-Jen Hwu, M.D., Ph.D., is encouraged by the increased survival rate among patients receiving a novel drug combination to treat melanoma that has spread beyond its original site.

Staging BATTL E A $9 million U.S. Department of Defense research grant will help clinicians take on lung cancer like never before. Biomarker-integrated Approaches of Targeted Therapy of Lung Cancer Elimination is a novel clinical trial program that will first explore and eventually prescribe treat-

Patients received low-dose temozolomide daily for six weeks, with a two-week break between cycles, and a weekly injection of very low-dose pegylated interferon. More than one-half of patients had either objective clinical responses or stable disease, Hwu says. With surgery, those with partial or mixed responses were rendered free of clinically detectable disease.

ments based on the genetic and molecular profile of a patient’s tumor.

“While it’s good to have improved responses,” Hwu says, “the most important question is, ‘Did our patients live longer?’”

highly individualized treatments for each patient.

The answer is “yes,” she says. “Patients with late-stage melanoma typically live six to nine months. With this combination therapy, more than one-half of the patients on this study survived one year or more, so we’re making progress.”

After a panel of tumor markers is identified and assessed, patients with advanced non-small cell lung cancer will be enrolled in one of several Phase II trials testing agents that target abnormalities in their cancer. A novel adaptive randomization statistical design will be applied to the clinical trials to accelerate the identification of

As part of the program, investigators also will study the mechanisms of response or resistance to existing and newer targeted agents, explore novel signaling pathways for future trials and identify molecular features in tumor and adjacent normal tissues that correlate with treatment outcome.

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N u r s e P r o f i l e / M a r y B e t h R i o s , R. N.

Just a Phone Call Away Mary Beth Rios, R.N., planned to stay only a year when a nurse recruiter convinced her to come to M. D. Anderson in 1975. “I had just finished nursing school in Chicago and intended to return there to be a clinical nurse specialist in cardiology,” recalls Rios, research nurse manager in the Department of Leukemia and recipient of the 2006 Ethel Fleming Arceneaux Outstanding Nurse-Oncologist Award.

Rios, whose mother was a nurse, thinks she has “the best job in the nursing profession.” As a research nurse manager, she is responsible for more than 200 patients enrolled in at least seven active clinical trials that are evaluating promising new therapies for leukemia.

Long before being chosen for that honor, Rios was considered a model for M. D. Anderson’s core value of caring by her physician and nursing colleagues, as well as hundreds of leukemia patients who appreciate her prompt availability to answer endless questions and explain the intricacies of their therapies.

“I love being a research nurse. Virtually all of our patients are on clinical trials, so I get to know and interact with them throughout their treatments and follow-up care. I also understand their anxieties,” says Rios, who had surgery at M. D. Anderson in 1980 to remove a benign pituitary tumor.

“The standards Mary Beth has set have become a hallmark of excellence throughout the Division of Cancer Medicine,” notes Hagop M. Kantarjian, M.D., chair of the Department of Leukemia. He coordinated nominating her for the award given annually by The Brown Foundation, Inc., to recognize outstanding M. D. Anderson nurses.

“I won’t ever forget what it’s like being a patient and having to depend on others,” Rios stresses. “Each of our patients is going through a traumatic experience. I give them my cell number because I know that a three-minute phone call can save hours or perhaps days of stress when they’re worried about something.” — Mary Jane Schier

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Shelter From the Storm No one will forget the scenes of devastation as Hurricane Katrina cut a swath through Louisiana, Mississippi and Alabama in August 2005. Houston escaped the destruction caused by the hurricane and its aftermath. But with typical compassion and skill, M. D. Anderson employees sprang into action to assist Gulf Coast neighbors fleeing the storm’s wrath. Many M. D. Anderson physicians, nurses, pharmacists and other caregivers spent their free time providing medical help to hurricane evacuees at Houston’s Reliant Astrodome and George R. Brown Convention Center. Other staff members sorted and distributed clothing at shelters and opened their homes to evacuees. “I was proud of our employees,” says Thomas W. Burke, M.D., executive vice president and physician-in-chief. “We had a wonderful response that mirrored the warmth shown by others throughout Houston.” More than 1,000 new cancer patients from areas wrecked by Katrina received care at M. D. Anderson. Another 811 patients from affected regions already were being treated at the institution when Katrina hit or were patients who returned for additional treatment following the storm.

When evacuees from Hurricane Katrina arrived in Houston, Maura Polansky, director of M. D. Anderson’s Physician Assistant Program for Education, spent her vacation volunteering at Houston’s Reliant Astrodome, providing medical assistance and emotional support.

A Baby’s Gift

Besides caring for patients’ physical needs, staff members from various areas — including psychiatry, chaplaincy and pastoral education, social work, case management and the employee assistance program — helped patients displaced by the hurricane cope with the issues they faced as a result of losing homes, possessions and even family members.

The very lifeline that once connected a mother to

Many of the new patients already had started cancer treatment at their local hospitals when they arrived in Houston.

an option for patients needing a bone marrow

“Our teams worked with patients who came in on short notice and with inadequate records or a hazy understanding of their condition. Everyone was good about adjusting to these unusual circumstances,” Burke says.

Houston hospitals, collecting cord blood units from

Our physicians and nurses often became “detectives,” working with insurance companies and laboratories to find patient information and contacting the American Society of Clinical Oncologists and other professional organizations to track down hometown physicians.

than 2,600 cord blood units have been collected and 1,700 units stored in

“Treating these patients was a challenge,” Burke says. “But with a combination of the patients’ knowledge of their cancer, the relative standardization of many cancer treatments and the dedication of our staff, we managed without significant interruptions to the patients’ care.”

her baby is increasingly becoming the nourishment many patients with cancer need to survive. A rich source of stem cells that work like those from the bone marrow, umbilical cord blood is

transplant. M. D. Anderson is partnering with other

consenting maternity patients. Since the first collection was taken in 2005, more

With help from moms-to-be, John McMannis, Ph.D., hopes M. D. Anderson’s Cord Blood Bank will become one of the largest and best programs in the world.

M. D. Anderson’s Cord Blood Bank, which has received donations of $35,000 and $25,000 from The Cockrell Foundation and Cockrell Family Fund, respectively. Five units already have been used for transplant. In 2006, the Cord Blood Bank received accreditation from FACT-NETCORD and the National Marrow Donor Program, which awarded the blood bank $500,000. M. D. Anderson also was selected by the Health Resources and Services Administration of the federal government to participate in the C.W. Bill Young Cell Transplantation Program’s National Cord Blood Inventory and awarded a contract of $3 million for the first year with additional funding for the second and third years. 11

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Tiny Particles Pack Powerful Punch by Scott Merville

MISSION: Research

Nanoparticles — molecules so small that they are measured in billionths of a meter — have a talent for gathering inside tumors. After slipping through large pores in leaky blood vessels that nourish tumors, these tiny materials can be taken up into the cancer cells. Their potential to destroy tumors is being tested by M. D. Anderson researchers, who are investigating the use of nanoparticles to deliver therapy, imaging agents or both. “Nanoparticles can be used for both therapy and diagnostics,” says Chun Li, Ph.D., professor in the Department of Experimental Diagnostic Imaging. Combining the two functions in one nanoparticle would allow “you to watch where the therapy goes and monitor the treatment in real time.” Li is developing such a particle. With a $2.5 million, five-year National Cancer Institute Nanotechnology Platform Partnerships program grant, Li also is working with Eastman Kodak to develop nanoparticles that bind to tumors and light up under near-infrared light. Near-infrared fluorescence-based optical imaging is sensitive, involves no ionizing radiation and allows real-time visualization, he says. Carbon molecules band together to form the basis of nanogrids and buckyballs, which can then be used to carry chemotherapeutic agents directly to tumors. Through collaborative studies, Chun Li, Ph.D. (left), is among many who are exploring the potential of these nanoparticles to detect, diagnose and treat cancer.

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Li has connected molecules of the drug paclitaxel to a nano-sized, water-soluble polymer, which appears to heighten the chemotherapy’s effect. Polymers are molecules that consist of repeated structural units. That combination is being tested in a Phase III lung cancer clinical trial sponsored by Cell Therapeutics, Inc. Nanoparticles, researchers say, will work best with a targeting component that binds to cancer cells and avoids normal tissue.

Hitching a ride Michael Rosenblum, Ph.D., professor in the Department of Experimental Therapeutics, specializes in targeting constructs — antibodies, growth factors, peptides — that home in on cancer. He has three drugs in development, which combine a targeting component with a cancer toxin. One is being evaluated in a Phase I clinical trial. While these fusion proteins are not nanoparticles, Rosenblum is collaborating with colleagues from Rice University to examine the potential role of fullerenes in a fusion approach. Also called buckyballs, fullerenes are nanospheres of 60 carbon atoms. The researchers reported last year that buckyballs can carry chemotherapeutic agents such as Taxol. They also showed a single antibody that targets skin cancer is capable of carrying up to 40 buckyballs, which did not hinder the antibody’s cancer-targeting ability. The findings raise the possibility of developing powerful, tightly targeted therapeutics by attaching buckyballs loaded with drugs to an antibody or other targeting molecule, Rosenblum says.

As good as gold With its low toxicity and well-known optical, biological and biodistribution properties, gold is an attractive nanomaterial, says John D. Hazle, Ph.D., chair of the Department of Imaging Physics. Hazle collaborates with researchers at Rice, who invented gold nanoshells, and Nanospectra Biosciences to exploit the unique optical properties of nanoshells in oncology. The nanoshells under investigation are spheres of silicon coated with gold. When exposed to near-infrared light, they become intensely hot and burn the tumor cells or microvasculature, Hazle says. His team is working with several groups on attaching biological entities to permit a more targeted approach. Renata Pasqualini, Ph.D., and Wadih Arap, M.D., Ph.D., both professors of medicine in the Departments of Genitourinary Medical Oncology and Cancer Biology, are harnessing gold to viral particles, creating a “nanoshuttle” to target tumors. The viral particles are engineered to zero in on the target tissue’s vascular “zip code.” Earlier, they discovered that the human vascular system has unique molecular addresses for different organs and tissues. In a laboratory study, they found that targeted viral and gold nanoparticles could be “tuned” to destroy tissue or emit signals detected by imaging devices. The system can be adapted to carry drugs, genes or restorative stem cells.

Fatty vehicles Buckyballs and other materials pose an additional challenge — how to get rid of them after they deliver their payload. Biodegradable nanoparticles such as liposomes or constructs made from cholesterol dissolve at delivery.

M. D. Anderson’s Michael Rosenblum, Ph.D. (seated), and Rice University’s Lon Wilson, Ph.D., have demonstrated that nanoparticles called buckyballs (pictured below) could significantly boost the payload of drugs carried by tumor-targeting antibodies.

R e s e a r c h

Jack Roth, M.D., delivers cancer-fighting genes to tumors by encasing them in a cholesterol formulation that binds to the membrane of cancer cells. Once inside the cell nucleus, the gene expresses a protein that kills the tumor cells, says Roth, who recently retired as chair of the Department of Thoracic and Cardiovascular Surgery. Based on Roth’s preclinical studies, nanoparticles carrying the tumor-suppressor gene FUS1 are being delivered to patients with metastatic lung cancer in a Phase I clinical trial. “So far it looks promising with little toxicity,” Roth says. The delivery system can be engineered to meet the characteristics of a patient’s tumor. Roth also is collaborating to develop “theranostic” nanoparticles that deliver therapeutic and diagnostic agents.

Quiet, please Nanoparticles also can be used to silence cancer-promoting genes. Gabriel Lopez-Berestein, M.D., professor in the Department of Experimental Therapeutics, and Anil K. Sood, M.D., professor in the Departments of Gynecologic Oncology and Cancer Biology, employ a fatty sphere called a liposome to deliver short interfering RNA (siRNA) directly and deeply into cancer cells. RNA translates genetic information into proteins. Targeted siRNA can gum up RNA, preventing creation of a harmful protein. In preclinical studies, their siRNA liposome turned off a gene critical to ovarian tumor growth and decreased new blood vessel development. The best effect was seen when combined with chemotherapy. They hope to see equally positive results in the clinic.

No Ordinary Atlas M. D. Anderson was selected by the National Cancer Institute and National Human Genome Research Institute as one of the first three sites to provide tumor specimens for a pilot study to determine if a reliable atlas can be

Lopez-Berestein and Sood collaborate with Mauro Ferrari, Ph.D., in early research of multiple-stage nanoparticles. “Each stage of the multi-layered particle would be equipped with a different therapy to overcome barriers that any drug faces in the body,” says Ferrari, who holds a joint appointment at The University of Texas Health Science Center at Houston and M. D. Anderson and is president of Houston’s Alliance for NanoHealth.

made for the genetic changes that eventually

The Alliance for NanoHealth awarded $2 million in seed grants for research projects in 2006. M. D. Anderson researchers lead four of the 10 diverse projects.

the biological material that will define the

While nanotechnology remains a work in progress, Lopez-Berestein is encouraged by the varied approaches. “Scientists are trying everything to make effective nanoparticles.”

emerging data that may uncover genomic

lead to cancer. As part of the Cancer Genome Atlas project, M. D. Anderson investigators will contribute

genome of glioblastomas and analyze

alterations responsible for turning normal brain cells into this most aggressive cancer. Genes involved in lung and ovarian cancer also will be studied at M. D. Anderson and elsewhere in the initial $100 million pilot phase of the genome project. Eventually, a comprehensive “atlas” describing genomic changes in all cancers will be developed. A genetic map of cancer cells will advance the development of targeted drugs for treatment, as well as the molecular imaging tools for cancer prevention efforts.

While a post-doctoral student, Eylem Ozturk had the opportunity to work with Gabriel Lopez-Berestein, M.D., who is investigating ways to deliver drug-bearing nanoparticles directly and deeply into cancer cells. 15

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W h i t e

Each Day is a Gift Betty White learned the ropes of being a cancer patient quickly. “You are your own best advocate,” she says. “You know your body better than anyone else so you need to pay attention to what it’s telling you so that you can talk to your doctor.” White is a nine-year ovarian cancer survivor. She knows that she was lucky — she caught the disease at an early stage.

and “continues to knock on wood every day,” counting each day as a gift.

“I was very fatigued and had some lower abdominal pain so I went to the doctor,” she explains. But the cancer didn’t show up in the tests her physician ran. Three months later, the symptoms were still troubling her so she had a laparoscopy and then a complete hysterectomy. This time, the lab results showed cancer.

For the last four years, she’s made frequent trips to M. D. Anderson, but now she comes here as a volunteer. White does double-duty, volunteering in the Anderson Network Hospitality Center in the Main Building and in the Gynecologic Oncology Center.

White’s doctor referred her to M. D. Anderson, a coming home of sorts for her. As a former employee, she knew this was the right place to be. White underwent six courses of chemotherapy

“I remember how it felt when I was here as a patient. I can help combat fear and offer hope,” White says. “Volunteering at M. D. Anderson is so rewarding. I tell everyone that if I can do it, you can, too.” — Gail Goodwin

R e s e a r c h

Missing in Action Thousands of genes reside in every human cell, each one having a specific function. When one goes missing or gets deleted, it can disrupt the natural order of things and cause disease.

In a series of experiments, Lin and his colleagues showed that BRIT1 activates two of these checkpoint pathways — ones that respond to damage caused either by ionizing or ultraviolet radiation.

A discovery made by Shiaw-Yih Lin, Ph.D., and his team further supports this fact.

They also discovered that when they inactivated this gene in normal human mammary epithelial cells, chromosomal abnormalities occurred in 21 percent to 25 percent of cells. No defects were seen in those cells expressing BRIT1. When these cells were exposed to ionizing radiation, 80 percent of them had chromosomal defects.

They identified a single gene, BRIT1, that plays a pivotal role in launching two DNA damage detection and repair pathways, suggesting that it functions as a previously unknown tumor suppressor gene. They also reported in the journal Cancer Cell that this gene, initially identified as a repressor of an enzyme responsible for cell division, is under-expressed or deleted in several cancers. “Disruption of BRIT1 function abolishes DNA damage responses and leads to genomic instability, which fuels the initiation, growth and spread of cancer,” says senior study author Lin, assistant professor in the Department of Systems Biology. A signaling network of molecular checkpoint pathways protects the human genome by detecting DNA damage, initiating repair and halting division of the damaged cell so that it doesn’t replicate.

Lin and his team also found reduced expression of BRIT1 in 35 of 87 cases of advanced ovarian cancer, and in breast and prostate cancer tissue, compared with non-cancerous cells. Genetic analysis of breast cancer specimens, for example, revealed a truncated, dysfunctional version of the BRIT1 protein. Loss of DNA damage checkpoint function and the ability to proliferate indefinitely are two cellular changes required for cancer development. Lin and his colleagues have tied BRIT1 to both factors and are now determining whether current therapies are effective in treating BRIT1-deficient tumors.

Shiaw-Yih Lin, Ph.D., and his colleagues found that loss of a specific gene leads to genomic instability and growth of several cancers.

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Turning on Oneself If Seiji Kondo, M.D., Ph.D., had any say, tumors would see the error of their ways and self-destruct without provocation. But as he knows, tumors act on their own volition and will do anything to survive. Simply willing them to die isn’t enough. So Kondo and his colleagues enlisted the help of an engineered virus that they hoped could do the job. hTERT-Ad, they reported in the Journal of the National Cancer Institute, successfully located and forced malignant glioma cells in mice to devour themselves, a process called autophagy. The modified virus infected and induced autophagy by inactivating a molecular pathway known to prevent cellular self-consumption. This shutdown resulted in prolonged survival and a 20 percent reduction in tumor volume among mice receiving hTERT-Ad, compared to those getting a different, non-replicating virus. These mice also lived longer, with those treated with three injections of hTERT-Ad surviving an average of 53 days versus 29 days for those in the control group. “This virus uses telomerase, an enzyme found in 80 percent of brain tumors, as a target,” explains senior study author Kondo, associate professor in the Department of Neurosurgery. “Once the virus enters the cell, it needs telomerase to replicate. Normal brain tissue doesn’t have this enzyme, so this virus replicates and functions only in cancer cells.” Other cancers also are telomerase-positive, and investigators showed that the virus kills both human prostate and cervical cancer cells while sparing normal tissue. Analyses of dead cancer cells showed telltale signs of autophagy — bits of virus in the cell nucleus and cavities containing residual digested material — but no indication of having been killed by apoptosis, a much better known process of programmed cell death. Apoptosis and autophagy should be viewed as type 1 and type 2 versions of programmed cell death, Kondo says. He adds that to improve therapeutics, it’s vital to identify molecules that regulate autophagy in cancer cells and to understand how this protective mechanism is associated with cell death, a relatively new field of cancer research.

In a study led by Seiji Kondo, M.D., Ph.D., researchers found that an engineered virus successfully located, infected and destroyed brain cancer cells in mice by inactivating a molecular pathway known to prevent cell death.

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An Unlikely Pair Like two peas in a pod, a bacterial and animal virus combine to serve as a vehicle for targeted delivery of genes to tumors and their blood vessels. In a study reported in the journal Cell, lead author and research scientist Amin Hajitou, Ph.D., says the creation of this new hybrid virus and its ability to find, highlight and transport genes to tumors is an important step forward in making cancer both more visible and accessible to treatment. It may also provide a way to predict and monitor the effects of anticancer drugs. Under the direction of Renata Pasqualini, Ph.D., and Wadih Arap, M.D., Ph.D., both professors of medicine in the Departments of Genitourinary Medical Oncology and Cancer Biology, Hajitou created and characterized the hybrid virus by combining genetic elements and biological attributes of an animal virus with those of a bacterial virus. Unlike animal viruses that infect mammalian cells, bacterial viruses have evolved to infect only bacterial hosts. These bacterial viruses, however, can be genetically adapted to bind to specific mammalian cells and then enter them. In tumor-bearing mice, researchers showed how particles of the hybrid virus, called AAV phage, can target tumors systemically to deliver an imaging or therapeutic agent, thereby providing a strategy for finding tumors and genetically manipulating them for imaging and therapy.

A new hybrid virus created and characterized by Amin Hajitou, Ph.D., is showing promise as a potential strategy for finding and transporting corrective genes to tumors.

Mystery Solved

The AAV phage hybrid combines the ability of the adapted bacterial virus to target specific tissues with the capability of the animal virus to actually deliver genes to cells. The crucial vehicles, or vectors, in the AAV phage hybrid retained the properties of their respective parental viruses, which the researchers called a surprising and efficient outcome. Pleased by the strong effects of this gene transfer in mouse models of breast and prostate cancer, Hajitou next worked with Juri Gelovani, M.D., Ph.D., chair of the Department of Experimental Diagnostic Imaging, who used positron emission tomography to confirm that the reporter and therapeutic genes were efficiently and selectively expressed throughout the animal tumors, and not in normal tissues. Although researchers have yet to translate these hybrid viruses for use in humans, they’re optimistic that this new system will have future clinical applications in diagnosing, treating and monitoring tumors more accurately.

More than 150 years after the discovery of Hassall’s corpuscles, the function of these globular bodies of cells in the human thymus gland has now been explained. The answer ends an intense, years-long hunt for the origin of regulatory T cells. Reporting in the journal Nature, M. D. Anderson researchers found that Hassall’s corpuscles produce chemical signals that instruct dendritic cells in the thymus to produce regulatory T cells, which patrol the body looking for “bad” T cells that can lead to autoimmune disease. A beneficial role of regulatory T cells is to inactivate damage caused by errant T cells. But in cancer patients, they suppress any natural reaction the immune system might have mounted to fight the cancer. The discovery, researchers say, may help provide clues as to how tumors use regulatory T cells to work on their behalf. It’s speculated that tumors may be converting normal T cells into regulatory T cells to protect themselves.

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I n v e s t i g a t o r P r o f i l e / A n i l K . S o o d , M. D.

Unique Opportunities The passion with which Anil K. Sood, M.D., conducts translational research stems from losing his father to aggressive prostate cancer almost a decade ago. “As a surgeon, I can help some patients, but it’s through research focused on understanding the biology of cancer that we’ll find the real answers to this disease,” states Sood, professor in the Departments of Gynecologic Oncology and Cancer Biology. Since joining M. D. Anderson in 2002, Sood has combined innovative laboratory research with performing complex surgical procedures and teaching graduate students about cell signaling pathways. His research involves evaluating the effect of neuroendocrine stress hormones on ovarian cancer growth and progression. To do this, he is developing novel anti-vascular therapeutic approaches and designing strategies for delivering short interfering RNA (siRNA) to halt production of selected proteins in ovarian cancer cells. “siRNA is a technology we can use to silence genes, shutting down production of a harmful protein known as focal adhesion kinase, which helps ovarian cancer cells survive and spread,” Sood explains.

In a mouse-model experiment, Sood’s team demonstrated that microscopic fatty envelopes called liposomes can be loaded with siRNA and injected into mice in which human ovarian cancer cells are growing. Animals receiving the liposomal siRNA had reductions in tumor weight, ranging from 44 percent to 72 percent compared with mice in control groups. “We hope to develop this approach for clinical use in the future,” Sood says. Sood’s interest in biology began as a boy in India, where his grandfather was a community physician. After receiving his medical degree from the University of North Carolina Medical School in 1991, he completed an obstetrics and gynecology residency at the University of Florida’s Shands Teaching Hospital and a fellowship in gynecologic oncology at the University of Iowa Hospitals and Clinics. “The spirit of collaboration and the resources are wonderful at M. D. Anderson,” Sood notes. “I have unique opportunities to develop new approaches, starting with an original idea and taking it through the lab to animal studies and into the clinic.” — Mary Jane Schier

R e s e a r c h

When Good DNA Goes Bad Just ask Karen Vasquez, Ph.D., associate professor in the Department of Carcinogenesis, what happens when good DNA goes bad. She and her team at M. D. Anderson’s Virginia Harris Cockrell Cancer Research Center in Smithville, Texas, reported in the Proceedings of the National Academy of Sciences that when otherwise normal DNA adopts an unusual shape called Z-DNA, it can lead to the kind of genetic instability associated with cancers such as leukemia and lymphoma. For the first time, they demonstrated that the oddly shaped DNA can cause DNA breaks in mammalian cells. Sequences prone to forming Z-DNA are often found in areas of DNA that are susceptible to the genetic rearrangements associated with cancer. Analysis of the genome reveals that DNA sequences prone to forming the Z-DNA structure occur in 25 percent of the genome. This awkward shape puts a strain on the DNA and as Vasquez and her colleagues showed, it can cause the DNA molecule to completely break apart. To determine whether the presence of Z-DNA could have an effect on DNA stability in a cell, researchers introduced pieces of DNA designed to form the Z-DNA shape into bacterial and human cell lines. They then broke apart the cells and examined what happens to their DNA. They found that in bacterial cells, the Z-DNA caused small deletions or insertions of one or two DNA base pairs, while it led to large-scale deletions and rearrangements of the DNA molecule in human cells. “We found that DNA itself can act as a mutagen, providing a plausible mechanism for how the chromosome breaks in a particular region to form cancer,” says Vasquez, whose research has been furthered by generous donations from The V Foundation for Cancer Research and the George and Barbara Bush Endowment for Innovative Cancer Research. “Once we better understand the players involved in the process,” she adds, “we might be able to either prevent the generation of these breaks or even correct them after they occur and before they cause cancer.”

Karen Vasquez, Ph.D., and her team have discovered that when DNA adopts an unusual shape, it may lead to cancer.

Specialized Support M. D. Anderson was awarded a record 10th National Cancer Institute Specialized Programs of Research Excellence (SPORE) grant, which supports collaborative translational research that applies laboratory findings to clinical care. The three-year, $4.6 million breast cancer SPORE will fund five research projects, all of which advance personalized risk assessment, detection and treatment of breast cancer. It also will fund research addressing genetic differences among minority populations and how disparities may affect prognosis, according to SPORE principal investigator Gabriel Hortobagyi, M.D., chair of the Department of Breast Medical Oncology. M. D. Anderson continues to hold more SPORE grants than any other institution, including ones in bladder, ovarian, pancreatic, prostate, uterine, leukemia, melanoma and head and neck cancers. The institution also shares a lung SPORE with The University of Texas Southwestern Medical Center in Dallas. With the breast cancer SPORE and the recent renewals of the ovarian and bladder SPOREs, the 10 grants now total more than $107 million.

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Right Time, Right Place to Make a Difference by Mary Jane Schier

M I S S I O N : E d u c a t ion

Padmanee Sharma, M.D., Ph.D., decided to be a doctor soon after recovering from a childhood accident. “A wonderfully kind pediatrician took care of me during my hospital stay,” Sharma remembers, “so I began thinking about how I could help people if I became a doctor.” She discovered “the excitement of doing my own laboratory experiments” while getting a bachelor’s degree in biology and a master’s in biotechnology at Boston University. Her goal to combine caring for cancer patients with conducting research in immunology evolved at Pennsylvania State University, where she earned a medical degree and Ph.D., and won awards for both research and clinical achievements. That’s why she was thrilled to be chosen in the fall of 2005 for M. D. Anderson’s Physician-Scientist Program, which is providing her with protected time to combine medicine and research.

In labs throughout M. D. Anderson, researchers are using highly sensitive tools to monitor treatment response. The ELISPOT assay, for instance, is allowing Padmanee Sharma, M.D., Ph.D. (left), and her colleagues to identify and correlate specific immune and tumor responses in patients who have received different immunotherapy agents, as well as to spot surrogate markers that predict better outcomes and adverse events.

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Established in 1998, the program prepares talented junior faculty to become future leaders in translational research. Participants are oncologists and many also have a Ph.D. To be accepted, each applicant must have demonstrated expertise in laboratory studies as well as clinical care and express a commitment to translational research. “Our program gives participants dedicated laboratory time, financial resources and mentoring guidance over a three-year period to develop independent research that will apply new knowledge more rapidly to improve clinical cancer care,” explains Robert C. Bast Jr., M.D., vice president for translational research.

Patient motivation Seeing patients each Tuesday in the Genitourinary Center inspires Sharma to work harder on her research to develop new immunotherapy strategies that will improve combination therapies for many more patients. “I love the interaction with patients, and I am fascinated with research. During my medical oncology rotation, I saw the urgent need for better therapies,” says Sharma, assistant professor in the Departments of Genitourinary Medical Oncology and Immunology at M. D. Anderson. Having two senior faculty leaders as her physician-scientist mentors is helping Sharma make progress faster than she hoped. “They are incredibly supportive,” she says about Christopher J. Logothetis, M.D., and Yong-Jun Liu, M.D., Ph.D., who chair the Departments of Genitourinary Medical Oncology and Immunology, respectively. Sharma’s research involves identification and correlation of immune responses, tumor responses and adverse events in bladder and prostate cancer patients who have been treated with different immunotherapy agents. “My lab handles blood and tissue samples from patients with bladder and prostate cancer. We assess their baseline immune responses and track changes over the course of their treatment to identify surrogate markers that predict for better outcomes. We can improve some patients’ immune responses, which correlate with improvement in tumor responses, with either the NY-ESO-1 DNA vaccine or the anti-CTLA4 monoclonal antibody,” Sharma explains. In the Genitourinary Center, she is the principal investigator on an early neoadjuvant clinical trial to evaluate immunological changes that occur in bladder cancer after treatment with anti-CTLA4 therapy. Sharma appreciates her time in the clinic because “caring for the patients drives my vision for more productive research.” Sharma says being in the Physician-Scientist Program illustrates “this is truly the right time and the right place for immunotherapy to be developed to make a difference for patients with cancer.”

Full speed ahead Bast says the program’s first 12 graduates are conducting outstanding research that already has been transferred to several clinical trials and used to design promising targeted therapies for many cancers. Another 13 junior faculty taking part in the program are focusing on multiple areas, including childhood cancers, surgery, laboratory medicine, leukemia, brain tumors and radiation therapy.

Faye M. Johnson, M.D., Ph.D., appreciates the funds and mentoring provided by the Physician-Scientist Program at “a critical time in my career.” Her laboratory research exploring alterations in growth factor signaling has led to several clinical trials for lung and head and neck cancer patients.

E d u c a t i o n

Putting it Down in Words M. D. Anderson has a long history of educating health care professionals, helping them develop the knowledge and expertise necessary to advance cancer care. This past year is no exception as the institution’s faculty wrote the Manual of Medical Oncology, a comprehensive guide emphasizing M. D. Anderson’s multidisciplinary care approach to the clinical management of cancer and its complications. Spearheading development of the manual were Hagop Kantarjian, M.D., chair, and Charles Koller, M.D., professor in the Department of Leukemia, respectively; and Robert Wolff, M.D., Participating in the Physician-Scientist Program was “a phenomenal experience” for Guillermo Garcia-Manero, M.D., whose research has led to new approaches for patients with acute leukemia and myelodysplastic syndromes.

Guillermo Garcia-Manero, M.D., associate professor in the Department of Leukemia, credits the program with “helping move my research ahead at full speed” and obtaining four major grants to support studies that are leading to new approaches for patients with acute leukemia and myelodysplastic syndromes. Born on the Spanish island of Majorca, Garcia-Manero received his medical degree from the University of Zaragoza in Spain. After postgraduate training from internship through his fellowship in hematology at Thomas Jefferson University in Philadelphia, he joined M. D. Anderson in 1999 and was accepted into the Physician-Scientist Program in 2002. “I now spend about 75 percent of my time in the laboratory, trying to better understand and implement genetic information (known as DNA methylation patterns) to predict response to therapy. We have identified a number of genes that may be silenced in leukemia, and we hope to determine what they mean to patients’ prognoses,” explains Garcia-Manero, who has reported his research in more than 110 publications and at numerous conferences worldwide.

associate professor in the Department of Gastrointestinal Medical Oncology. Written exclusively by M. D. Anderson faculty and fellows — 95 contributors in total — the manual was designed to fill an important void in oncology reference material by serving as a hands-on resource for the practicing oncologist. It presents an overview of medical oncology as it’s currently practiced at M. D. Anderson. Published by McGraw-Hill, the 1,149-page guide covers 10 disease sites and issues surrounding supportive care, palliative care and symptom management, and long-term survival.

His analysis of the Physician-Scientist Program: “It was a phenomenal experience.”

Committing to education The Physician-Scientist Program is funded primarily by donors. During the past year, more than 65 individuals and foundations contributed in excess of $1.1 million to support the program. Major donors included Guerra Brothers Successors, Ltd., Mr. and Mrs. Ben Guill, the RGK Foundation, the Rockwell Fund, Inc., The Louis and Rachel Rudin Foundation, and The Gil and Dody Weaver Foundation. Nine M. D. Anderson senior faculty also contributed to the program.

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To the Edge and Back A nurse herself, Janice Duplessis knew that she wanted to be involved in decisions about her care when she was diagnosed with breast cancer. With 31 positive lymph nodes, Duplessis worked hand-in-hand with her physician through a comprehensive and aggressive treatment plan. After researching her options, she underwent a mastectomy of her right breast, followed by intensive chemotherapy, radiation and eventual reconstruction. “I was scared,” Duplessis recalls, “but M. D. Anderson gave me hope when I didn’t think there was any.” Today, Duplessis lives in a houseful of breast cancer patient advocates. From her husband, who is her “biggest cheerleader,” to her three sons, everyone is on her bandwagon.

“This is a 24/7 kind of awareness for me,” she says. “I believe that God has left me here for a reason.” Duplessis takes her advocacy seriously, volunteering for the American Cancer Society, the Komen Foundation and the Anderson Network at M. D. Anderson. In addition to her telephone outreach work, she will chair the annual Anderson Network patient conference next fall. “I tell every patient something I heard when I was diagnosed: not everyone gets the opportunity to walk to the edge and look over and then be able to walk back,” Duplessis says. “I’ve been given that opportunity and I’m not going to waste it.” — Gail Goodwin

E d u c a t i o n

A Unique Nursing Experience “It’s almost too good to be true,” Elizabeth Sorensen says. Maria D. Guerrero echoes her sentiment, “It’s a great learning opportunity. I would encourage any advanced practice nurse to pursue it.” What’s got Sorensen and Guerrero so excited is M. D. Anderson’s Post-Graduate Fellowship in Nursing Oncology. These two are the “early pioneers” going through the program and they are enjoying every moment. “It’s been excellent. I’m learning about each disease site and seeing how different cancers are managed. It’s been an enlightening experience,” Sorensen says. Believed to be the first of its kind in the country because of its length, depth and scope, “this advanced practice nurse fellowship covers the full spectrum of cancer care from prevention to survivorship and end-of-life,” says Joyce Dains, fellowship co-coordinator and manager of the Professional Education for Prevention and Early Detection program. The yearlong fellowship offers advanced practice nurses the chance to develop their expertise in cancer care. Clinical practice combined with participation in classes, nursing research and a variety of rounds, conferences and professional activities provides a rich and comprehensive experience.

In partnership with The University of Texas Health Science Center at Houston’s School of Nursing, fellows take nine credit hours of post-graduate courses that focus on oncology nursing and evidence-based practice. They also engage in several specialty care courses offered at M. D. Anderson. The bulk of the program, however, is the time fellows spend with various health care teams throughout M. D. Anderson. Paired with advanced practice nurse preceptors during the year, fellows complete mandatory clinical rotations in prevention, cardiology, palliative care, infectious disease, psychology and endocrinology. They also can elect to rotate in other centers of interest. When all basic requirements are fulfilled, fellows choose a specialty area for clinical practice, which lasts about eight months. Here, they gain additional hands-on experience in treating patients and managing their follow-up care congruent with the role and function of M. D. Anderson advanced practice nurses. “The fellows are doing well,” says advanced practice nurse Carol Dallred, who coordinates the day-to-day aspects of the fellowship. “I hear nothing but good responses from everyone involved. Both of the fellows are creative and flexible, which are wonderful assets.”

Advanced Practice Nurse Marita V. Lazzaro (center) walks alongside Maria Guerrero (left) and Elizabeth Sorensen, who are the first to participate in a fellowship program that offers advanced practice nurses the chance to develop their expertise in cancer care.

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Educational Pursuits When major academic and medical institutions come together, good things can follow. So was the case as M. D. Anderson, The University of Texas at Austin and The University of Texas Health Science Center at Houston joined forces to form a new biomedical engineering department to operate in Houston and Austin. The inter-institutional department is part of the College of Engineering at UT Austin, with equivalent units at both Houston sites. It fosters collaboration through programs and incentives that include providing seed grants for new research, facilitating multi-investigator research and training grant proposals, and offering special educational programs and internships. The UT Center for Biomedical Engineering, formerly a partnership between the three institutions, became part of this new department. The center has expanded programs for translating basic discoveries into novel treatments and building cooperative arrangements with industrial partners. “We’re entering an age of medicine that will take detection, treatment and prevention to the molecular and patient-specific levels, and we must have the talent pool and expertise to develop and perfect the technologies needed to leverage this knowledge and care for patients,” says Charles Patrick, Ph.D., deputy chair ad interim of the Department of Biomedical Engineering at M. D. Anderson. Opportunities to educate the next generation of physicians and scientists extended further last year as bioengineering students from Rice University began making clinical rounds and taking coursework at M. D. Anderson as part of an innovative Ph.D. training program. Funded by a four-year, $850,000 Howard Hughes Medical Institute “Med to Grad” initiative award, the Translational Bioengineering for Cancer Diagnostics and Therapeutics program builds on four existing joint areas of research between M. D. Anderson and Rice. They include: computational bioengineering for design of cancer-inhibiting agents; molecular imaging for early cancer detection; nanobiotechnology for design of new cancer imaging and therapeutic agents; and cell and tissue engineering for development of effective reconstructive procedures after tumor resection. Students take courses taught jointly by M. D. Anderson and Rice faculty. By the end of the program, they will have completed an intensive clinical cancer internship and translational research rotation. As part of an innovative Ph.D. training program, Rice University bioengineering students have an opportunity to work with M. D. Anderson scientists who are generating fat-like tissues in the laboratory, which then can be used to reconstruct tissues, like the breast, that were removed after cancer surgery.

E d u c a t i o n

Stamp of Approval It was no easy task for Marilyn Greer, Ph.D., director of the Department of Institutional Research, and her six-member team to compile the extensive documentation necessary for M. D. Anderson’s academic programs to receive accreditation from the Commission on Colleges of the Southern Association of Colleges and Schools. Following an intensive process that spanned several years and involved many faculty, staff and students from M. D. Anderson and The University of Texas Health Science Center at Houston, Greer and her group prepared and shipped sets of key documents, totaling 160,615 pages plus appendices and other materials, to the commission for its review. In notifying M. D. Anderson of its initial five-year accreditation, SACS officials reported that the institution satisfied 11 core requirements, 67 comprehensive standards and eight federal requisites, and concluded that M. D. Anderson’s academic programs are very strong. They were “most impressed” by the comprehensive materials explaining the teaching activities, the one-to-one faculty-student ratio and how education is fully integrated with the “world-class research and clinical programs.” During a three-day site visit, the SACS accreditation committee “had only one minor recommendation,” says Stephen P. Tomasovic, Ph.D., senior vice president for academic affairs. “It concerned the way we evaluate our relationships with the Health Science Center and other academic institutions — and we were able to satisfy that request in just a few minutes.” Two key decisions preceding the SACS application were authorization in 1999 by the Texas Legislature and the Texas Higher Education Coordinating Board for M. D. Anderson to confer baccalaureate programs in allied health and in 2001 to jointly award master’s and Ph.D. degrees with the Health Science Center. Tomasovic notes that while M. D. Anderson “has always had a significant educational mission, the SACS accreditation is an important milestone because, for the first time, we are officially accredited as a degree-granting institution.” This is important to students, he adds, because accreditation is required for them to obtain financial aid from the federal government and other funding sources, as well as for students to transfer credits when they seek advanced degrees.

Institutional Research Director Marilyn Greer, Ph.D. (right), is proud of Maxine Stredic and others on her staff, who worked diligently for three years on the SACS application in addition to their other responsibilities to ensure that M. D. Anderson’s academic programs received national accreditation.

Just Ask Us Marking its 10th year, the M. D. Anderson Information Line took on a new identity and expanded focus in response to a growing number of people seeking information about M. D. Anderson programs, services and referral information. askMDAnderson, as it’s known today, assists individuals in: • Making an appointment • Understanding treatment options and clinical trials • Navigating the Web site • Finding out about patient amenities • Accessing prevention and screening services • Finding accurate cancer information • Locating cancer resources In addition, individuals can now receive general information about cancer and its treatment by contacting askMDAnderson. Since 1996, the service has helped 327,000 people. To learn more, call 1-877-MDA-6789 or visit www.mdanderson.org/ask.

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E d u c a t o r P r o f i l e / P e i L i n , M . D.

A Thirst for Knowledge As a child growing up in China, Pei Lin, M.D., was encouraged by her father to consider a medical career so she could “help people and be as valuable as possible.” Heeding his advice, she earned a medical degree at age 21 from Nanjing Medical University, where she was an instructor for four years before moving to the United States. She next received a master’s degree in American history and a bachelor’s degree in nursing, worked as a registered nurse in a neonatal intensive care unit and coordinated an AIDS clinical trial group. She then completed a medical residency in pathology at the Yale-New Haven Hospital.

a nurturing environment and opportunities to collaborate with clinical specialists performing many bone marrow and stem cell transplants,” Lin says.

“I was fascinated with pathology in medical school,” explains Lin, who came to M. D. Anderson in 1999 for a fellowship in hematopathology.

Lin, who was chosen M. D. Anderson’s Educator of the Month for February 2006, serves on the Surgical Pathology Fellowship Training Program Advisory Committee and the Graduate Education Committee. She has contributed to 45 peer-reviewed journal articles and four book chapters.

After two years at the University of Arkansas for Medical Sciences, Lin joined the M. D. Anderson faculty in 2002 and was promoted to associate professor of hematopathology in 2006. Until recently, she directed the Hematopathology Fellowship Training Program. “M. D. Anderson provides the largest pathology services anywhere, so the volume of work for the fellows is amazing. We offer them

Last year, the six fellows Lin supervised in the Bone Marrow Laboratory contributed to 15,087 comprehensive bone marrow studies, almost 12,000 bone marrow biopsy evaluations, 14,076 bone marrow aspiration and clot evaluations, 2,948 immunohistochemistry tests and other procedures.

“I’m thrilled and grateful to be part of M. D. Anderson,” says Lin, now assistant director of the Flow Cytometry Laboratory in the Department of Hematopathology. — Mary Jane Schier

E d u c a t i o n

Going Beyond Our Borders

Researchers and nurses from cancer facilities in 16 countries witnessed the formal signing of the Tianjin agreement at the second M. D. Anderson Sister Institution Conference in summer 2006, where trends in translational research, therapy and cancer prevention were discussed. “This historic agreement will help advance our mutual global agenda and benefit people worldwide,” says M. D. Anderson President John Mendelsohn, M.D. “By working closer together, we can all learn a great deal and help reduce the impact of cancer at a faster rate.” Faculty members at both institutions have collaborated on translational research projects in cancer pain management, genomics, molecular markers and breast and gastrointestinal cancers for more than a decade. As part of this new agreement, they plan to conduct further research in epidemiology, radiation oncology and tissue banking, as well as to provide training exchange opportunities for investigators. “Scientists at our institutions have been productive research partners, sharing the best developments and traditional practices in Eastern and Western medicine for the betterment of cancer patients,” says Xishan Hao, M.D., president and professor of surgical oncology at the Tianjin center. “We’re pleased to set in motion an agreement to advance our research and education missions.” M. D. Anderson also fosters other types of collaborative partnerships that are similar to the sister institution alignments but without formal signed agreements. One project includes translational research collaborations with Centro Nacional de Investigaciones Oncologicas, the prestigious national cancer research institute of Spain. Mendelsohn says “the success of M. D. Anderson’s sister institution program rests on the efforts of its faculty who develop the collaborative arrangements and the Office of Extramural Programs, which provides excellent initiative and support.”

Beij

Sister institutions are those with which M. D. Anderson has signed collaborative research and teaching agreements in other countries, so far including China, Brazil, Chile, India, France, Japan and Mexico. In part, these alliances are fueled by the fact that a large number of faculty members have long-standing ties with peers far from Houston. Almost 20 sister institution agreements have ratified some of these informal arrangements and others are pending.

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With the stroke of a pen, Tianjin Medical University Cancer Institute and Hospital became an M. D. Anderson sister institution.

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In an effort to conquer cancer worldwide, M. D. Anderson and Tianjin Medical University Cancer Institute and Hospital signed a sister institution agreement to expand collaborations in clinical, educational and translational cancer research. M. D. Anderson also has three other such formal agreements in China, including Beijing, Shanghai and Guangzhou.

The More You Know … The availability of clinical trials is a key reason why patients come to M. D. Anderson. Although individuals are increasingly sophisticated about finding information, “they always arrive with questions and issues to consider,” says Louise Villejo, executive director of the Patient Education Office. To help patients make informed decisions about participation, a booklet explaining the basics of clinical trials and how they are conducted at M. D. Anderson was developed. The booklet is part of a larger Institutional Clinical Trials Education Initiative. Led by the Patient Education Office, an interdisciplinary team is establishing processes to ensure consistency in clinical trials education for both patients and staff. Among their goals are to increase patient awareness of and access to clinical trials at M. D. Anderson, and to develop staff training curriculum, patient teaching guidelines and educational resources. In addition to the booklet, they developed a clinical trials module for U.S. News & World Report’s Web site last year and are about to launch a clinical trials video. Access the Clinical Trials Booklet at www.mdanderson.org/patients_public/clinical_trials/ 31

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An Ounce of Prevention by Scott Merville

M I S S I O N : P r e v e n t ion

Better diet. More exercise. Tobacco avoidance. When the issue is disease prevention, these important general categories come swiftly to mind. Prevention at M. D. Anderson is more sweepingly defined, yet focuses on crafting personalized approaches by tapping advances in medical and molecular research. “Prevention is broad,” says Bernard Levin, M.D., vice president and head of the Division of Cancer Prevention and Population Sciences. “It’s not just prevention of cancer development, but includes advances in early diagnosis and treatment that reduce suffering and mortality from the disease.” Levin anticipates a day when people will get a specific assessment of their personal risk of developing cancer based on their history, lifestyle and habits, exposure to carcinogens and genomic information. “That will lead to personalized preventive measures.”

Researchers are evaluating the psychophysiological aspects of nicotine dependence, measuring a person’s response to pleasurable and averse images to determine what triggers an individual to smoke. Bernard Levin, M.D. (left), vice president and head of the Division of Cancer Prevention and Population Sciences, says a time when cancer becomes an often-preventable disease is approaching as research advances in behavioral science, molecular epidemiology and chemoprevention yield results. 33

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What’s my risk? “Physicians have little to help them predict risk of lung cancer in their patients who are, or have been, smokers,” says Margaret Spitz, M.D., chair of the Department of Epidemiology. “Even a history of heavy smoking doesn’t always help since only a fraction of long-term smokers develop lung cancer.” Understanding factors that favor one smoker and condemn another would enhance early detection and open new treatment possibilities. Researchers are building risk-assessment models using clinical information available to physicians. For former smokers, they found that length of time they had stopped smoking, history of emphysema, no prior hay fever, dust exposure and family history are risk predictors. For smokers, the model includes intensity of smoking and asbestos exposure. For those who never smoked, passive exposure to tobacco smoke and family cancer history count. This model correctly classifies about 70 percent of lung cancer cases. The next step is to heighten its accuracy by incorporating genetic variation data into the model.

Predicting outcomes Genetic variations are known to raise a person’s risk for cancer, but can they also predict how a patient’s disease will unfold? Xifeng Wu, M.D., Ph.D., professor in the Department of Epidemiology, examined genes that are vital to the structure of telomeres, which cap and protect the ends of chromosomes. She and her colleagues found that lung cancer patients with high expression of one gene (RAP1) in their tumors had a median survival of 51 months versus only 15 months for those who didn’t. “It’s remarkable, because in lung cancer research, if you find something that adds three months, that’s significant,” Spitz says. RAP1 provides an intriguing target for therapy and researchers are refining its predictive value. Wu, Spitz and their colleagues also reported that genetic variations known to raise lung cancer risk, because they affect the capacity to repair tobacco-induced DNA damage, benefit patients treated with platinum-based chemotherapy. A robust repair system fixes damaged DNA that fuels cancer growth. A weak system allows cancer to develop. Yet the team found that patients with advanced lung cancer who received platinum-based chemotherapy lived nearly six months longer if they had genetically less efficient DNA repair than patients with efficient repair. Efficient DNA repair treats platinum’s attack on cancer the same way it treats DNA damage caused by tobacco carcinogens — it removes it, neutralizing the drug. “This genetic variation has the potential to guide treatment,” Spitz says. “Those with efficient DNA repair may need other therapy, or perhaps a more intense dose of platinum.”

Extinguishing tobacco Tobacco doesn’t just attack the lungs. It’s involved in cancers of the head and neck, esophagus, pancreas and more. Many smokers quit after diagnosis, but some have difficulty breaking nicotine’s grip, undermining their treatment. Last year, the Department of Behavioral Science introduced the Tobacco Treatment Program, which by late fall was serving 414 patients who cumulatively had visited 2,625 times. “It’s a free, comprehensive program for M. D. Anderson patients who use tobacco or who have quit within the last year, because we need to prevent relapse,” says program director Paul Cinciripini, Ph.D., professor in the Department of Behavioral Science.

Paul Cinciripini, Ph.D., hopes that M. D. Anderson’s Tobacco Treatment Program and the use of antidepressants in combination with behavioral modification will help smokers quit.

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Go Under Cover Despite new findings that melanoma is only partially associated with exposure to ultraviolet B radiation from the sun, the message is still the same — limit sun exposure and use a sunscreen that blocks both UVA and UVB rays. Therese Bevers, M.D., served as principal investigator on the STAR Trial at M. D. Anderson, which evaluated the effectiveness of tamoxifen compared to raloxifene in preventing breast cancer.

Reporting in the Journal of the National Cancer Institute, study lead Qingyi Wei, M.D., Ph.D., professor in the Department of Epidemiology, and his colleagues found that only non-melanoma skin cancers are strongly associated with UVB radiation exposure. They stress, however, that this doesn’t mean sun-

The program, funded by the Texas Tobacco Settlement Fund, offers counseling and medications that block or replace nicotine, which enhances neurotransmitters that elevate mood. “There also are important psychological variables to address: stress, mood, anxiety and depression,” Cinciripini says, so antidepressants are employed. Cinciripini now leads a clinical trial assessing how two common antidepressants affect a patient’s mood and whether genetics plays a role in their effectiveness. Cinciripini and colleagues reported last year that the new antidepressant venlafaxine helps some smokers quit when combined with nicotine replacement and counseling.

Drugs that prevent Chemoprevention involves finding and testing drugs that might stop cancer from developing at all. Levin led an international study showing that the anti-inflammatory drug Celebrex reduces formation of precancerous polyps that can lead to colorectal cancer. The drug’s cardiovascular risk complicates its general use as a preventive agent. “Maybe it’s not for use in average-risk people,” Levin says, “but for those at higher risk of developing colon cancer, it might offer some help.” Celebrex is currently approved for individuals with familial adenomatous polyposis, who are at the highest risk.

bathing poses a minimal risk of developing melanoma since UVA radiation can damage the DNA in the pigment-producing cells that give rise to this deadly form of skin cancer. Researchers examined the rate of chromosome breaks in skin tumors, finding that UVB radiation affected cell chromosomes more severely in patients with non-melanoma skin cancer compared to those with melanoma. A higher frequency of chromosomal breaks was associated with a more than two-fold increased risk for developing both basal cell and squamous cell carcinoma.

M. D. Anderson also played a major role in a breast cancer chemoprevention trial. Results from the Study of Tamoxifen and Raloxifene showed that both drugs reduce breast cancer risk by 50 percent for postmenopausal women considered at increased risk. Raloxifene, an osteoporosis drug, had fewer side effects and also didn’t have the risk of uterine cancers seen with tamoxifen, notes Therese Bevers, M.D., associate professor in the Department of Clinical Cancer Prevention and principal investigator on the STAR trial at M. D. Anderson. Participants in the trial have received information about which drug they were taking. Women assigned to raloxifene will continue to be provided with the drug until they have completed five years of treatment, according to Bevers. Those women assigned to tamoxifen can choose to continue taking the drug or switch to raloxifene to complete their treatment.

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Making Music Together Guitarist Rhett Butler found a unique way of saying “thank you” to those at M. D. Anderson who have cared for his brother, Ashley. He established the Ashley Grant Butler Pediatric Assistance Endowment at M. D. Anderson. Proceeds from concerts and the sale of his CDs are directed through Rhett Butler Records to the endowment, which is designed to help families of pediatric patients at M. D. Anderson with housing expenses during extended cancer treatments. In 1982, Ashley was diagnosed with a rare brain cancer called primitive neuroectodermal tumor, or PNET. Ashley and his mother lived at the Ronald McDonald House during his treatments in New York. Far from their home in Houston, they experienced the financial struggles many families encounter as they cope with cancer. A 2002 graduate of the Texas School for the Blind and Visually Impaired, Ashley enjoyed more than 20 years of

being cancer free before being diagnosed with a tumor in his neck in 2004. Subsequently, he underwent surgery at M. D. Anderson to remove it. Then, two years later, the cancer returned, requiring additional surgery and a round of chemotherapy. The family is encouraged by the results, says Butler, noting that Ashley is an inspiration for his music career. The endowment “is dedicated completely to Ashley,” says Butler, who is based in Denton, Texas. “I want Ashley’s name to live on forever at M. D. Anderson. It’s something that will be there to help people and to make a difference, long after all of us are gone.” — Sarah Watson

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The Weighty Truth While one’s scale can forecast an increase in pant size, it may also predict a much weightier truth — the silent progression of cancer. In a groundbreaking study, the first of its kind analyzing the role of weight on prostate cancer progression, Sara Strom, Ph.D., has unveiled some remarkable trends. She and her team reported in the journal Cancer that obesity is an independent predictor of whether localized prostate cancer will progress following radiation therapy. They found that moderately and severely obese patients had a 99 percent greater risk of developing “biochemical failure,” which is a rising prostate specific antigen level that can indicate advancing cancer. Researchers also found that obese patients had a 66 percent increased risk of tumor recurrence or metastasis than did non-obese patients. These findings mirror results from a parallel study reported in the journal Clinical Cancer Research. M. D. Anderson researchers found a history of weight gain or obesity at the time of diagnosis played an important role in how aggressive prostate cancer became after surgery.

Biochemical failure occurred more quickly in patients registering increases in their body mass index, which is a statistical measure of an individual’s weight scaled according to their height. These men also experienced a higher rate of cancer recurrence. “Together, these studies confirm that a man’s body mass index can be a significant factor in how well he fares after standard treatments for prostate cancer,” says Strom, lead researcher on both studies and associate professor in the Department of Epidemiology. “The fact that the same association was found among patients with different risk profiles, who were treated with different therapies, would suggest that poorer outcomes are related not as much to differences in treatment as to differences in tumor behavior between obese and non-obese men.” According to Strom, further study may reveal that a man’s history of body weight should be a factor oncologists consider when designing a treatment and follow-up plan for newly diagnosed patients with prostate cancer. “Understanding the mechanisms by which weight gain contributes to prostate cancer progression is an important first step in the development of rational, preventive strategies,” Strom says.

There is yet another reason to watch your weight, according to Sara Strom, Ph.D., who discovered that obesity is an independent predictor of whether prostate cancer will progress following surgery or radiation therapy.

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Not Just the Air You Breathe Cigarettes aside, genes and diet also play a role in whether a person — even a non-smoker — develops lung cancer or not. In one of the largest studies ever conducted, M. D. Anderson researchers found that first-degree relatives of lung cancer patients who never smoked had a 25 percent increased risk of developing any cancer compared to the control group. Additionally, their risk of developing lung cancer before age 50 was six times higher. According to study principal investigator Margaret Spitz, M.D., chair of the Department of Epidemiology, and Olga Gorlova, Ph.D., assistant professor, the average age of diagnosis was approximately 61 years among non-smoking relatives of lung cancer patients, as compared to 74 years for non-smoking relatives in the control group. The study included 2,465 first-degree relatives (parents, children and siblings) of 316 lung cancer patients who had never smoked, compared with a control group of 2,441 first-degree relatives of 318 people who did not have lung cancer and also had never smoked. “It has long been observed that cancer aggregates in some families, and with the help of this unique group of lung cancer patients and their relatives, we can begin to study the underlying genetic factors,” Spitz says. In a second case-controlled study, Spitz and Matthew Schabath, Ph.D., epidemiology postdoctoral fellow, note that a diet rich in plant-derived compounds that possess weak estrogen-like activity may reduce the risk of developing lung cancer. Among the more than 3,500 participants, they found that those who ate the highest amount of foods rich in dietary phytoestrogens had a 46 percent reduced risk of lung cancer, compared to those who ate the lowest quantity. These results build upon the team’s previously published findings that hormone replacement therapy was associated with a reduced risk of lung cancer. “While the best cancer prevention advice continues to be to stop smoking, these findings showing that specific dietary patterns resulted in lower lung cancer risk are tantalizing,” Spitz says. Olga Gorlova, Ph.D., and her colleagues found that first-degree relatives of lung cancer patients who have never smoked have an increased risk of developing cancer, suggesting they share an inherited genetic susceptibility to the disease.

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On Your Side While modern medicine continually opens new doors to cancer care, a few significant populations repeatedly find these entrances locked. M. D. Anderson’s Center for Research on Minority Health, however, hopes to remove the barriers many minorities, those of lower socioeconomic status and the medically underserved face in accessing health care services. “With a little extra assistance, we believe these individuals can overcome many of the obstacles they encounter and receive appropriate screenings and treatment,” says Lovell A. Jones, Ph.D., the center’s director and professor in the Department of Health Disparities Research. Through a $5 million grant from the Centers for Medicare and Medicaid Services, Jones and his colleagues have begun recruiting Hispanics into the Facilitated Assistance, Research and Outreach for Seniors Study. Project FAROS, which means “beacon of light” in Spanish, was initiated to assess the effectiveness of individual counselors in facilitating patients’ health care experiences. Researchers hope to apply innovative, evidence-based intervention models to reduce risk factors, as well as to increase screening rates, use of treatment and survival among patients with breast, cervical, colon, lung and prostate cancer in underserved populations. Eligible participants will receive personal “navigators” to help them receive timely, effective medical treatment and obtain appropriate follow-up care. Individuals will be randomly divided into an intervention group, which will receive navigation services, and a non-intervention group, which will receive information about local resources that can provide health care assistance. Navigators will assist patients by coordinating doctor appointments, identifying barriers to care and making referrals to other health care professionals. Cancer screenings will include a Pap test for cervical cancer; prostate specific antigen blood test and digital rectal exam for prostate cancer; fecal occult blood testing, with or without colonoscopy or sigmoidoscopy, for colorectal cancer; and mammography for breast cancer. Navigating the health care system can be difficult for any patient, but real barriers place some individuals at a significant disadvantage. M. D. Anderson aims to meet underserved patients where they are and provide much-needed facilitators to improve cancer prevention and treatment.

Lovell A. Jones, Ph.D., is leading an effort that pairs the medically underserved with a personal “navigator,” who will help them receive timely, effective medical treatment and appropriate follow-up care.

A Promise of Fresh Air Thousands of smokers live in multigenerational households and wouldn’t consider putting their parents and children in harm’s way. Yet these smokers’ choices barrage their loved ones with more than 4,000 chemical compounds and 60 known carcinogens each day. The Flight Attendant Medical Research Institute recently awarded Alexander Prokhorov, M.D., Ph.D., professor in the Department of Behavioral Science, a three-year, $900,000 Clinical Innovator Award to intervene. In the “Promoting Tobacco-Free Indoor Air Policy in Mexican-American Households” study, Prokhorov and his team will collaborate with their epidemiology colleagues to target Hispanic homes located predominantly in economically disadvantaged areas of Houston. Researchers will monitor exposure to secondhand smoke through self-reports and special monitors that detect nicotine in the air. Researchers also will educate participants about the dangers of second-hand smoke through a series of culturally appropriate fotonovelas, or illustrated storybooks, hoping to convince smokers that the health benefits of quitting are visible, dramatic and immediate.

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I n v e s t i g a t o r P r o f i l e / D a v i d W . W e t t e r , P h. D.

Dreams in the Making David W. Wetter, Ph.D., believes dreams can come true. As the founding chair of the Department of Health Disparities Research, Wetter says he is fortunate to lead an interdisciplinary team aiming to help underserved populations who bear an unequal burden of cancer. That his department is the first of its kind at any cancer center in the country illustrates the “remarkable vision, resources and collaboration,” which attracted him to M. D. Anderson in 1995. Since then, he has earned a broad reputation for research focused on tobacco cessation and health promotion among minorities and individuals living in poor socioeconomic conditions. Wetter’s interest in health and wellness began as a boy participating in multiple sports. He was named an Academic All-American as a point guard on the basketball team at Whitman College in Walla Walla, Wash., where he received a bachelor’s degree in economics. While completing a master’s in epidemiology and a Ph.D. in clinical psychology at the University of Wisconsin-Madison, he concentrated on studying nicotine and alcohol dependence. At M. D. Anderson, Wetter’s research has garnered extensive extramural support for tobacco-related studies that include biobehavioral theory testing in real-world settings, clinical trials

evaluating new treatment approaches and population-based interventions. Currently, he’s principal investigator on six National Institutes of Health grants. One of Wetter’s studies — Project MOM — is developing methods to help women who quit smoking while pregnant remain smoke-free. Project MOM includes a broad wellness program with strategies for women dealing with excess stress, weight management, depression and unemployment. Looking ahead, Wetter notes that his expanding department is “addressing health disparities from the societal to the molecular levels, with a goal of creating an environment in which differences in health due to race, ethnicity, socioeconomic status, gender and other factors cease to exist.” He admits this is an ambitious goal. “But I know that if you can dream something, you can achieve it at M. D. Anderson.” — Mary Jane Schier

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When East Meets West At the same time that M. D. Anderson is dedicated to pursuing the latest technology to improve the overall health of cancer patients, its researchers also are exploring the benefits of combining Western medicine with 5,000-yearold “energy-based” Eastern practices. The National Cancer Institute recently awarded M. D. Anderson a $2.4 million grant to study the effects of Tibetan yoga in women with breast cancer who are undergoing chemotherapy. With this grant support, Lorenzo Cohen, Ph.D., and his team will conduct a large randomized trial comparing Tibetan yoga versus simple stretching or usual breast cancer care. The award is the largest ever made to study Tibetan yoga in cancer patients, says Cohen, whose team published a 2004 study in the journal Cancer that found the practice led to significant sleep improvements in patients with lymphoma. The study will assess the physical and psychological benefits of the yoga program and examine such patient lifestyle factors as fatigue, sleep, mental health and distress. “Cancer and its treatment are associated with considerable distress, impaired quality of life, poor mental health and reduced physical function,” says Cohen, study principal investigator and director of M. D. Anderson’s Integrative Medicine Program. “This is particularly true for women with breast cancer who receive multi-modality treatment over an extended period of time. “For thousands of years,” he adds, “Tibetans have been employing a form of yoga that we think could help improve the treatment-related morbidity that accumulates over time in cancer patients.” In addition to the yoga study, NCI also awarded M. D. Anderson and Fudan University Cancer Hospital in Shanghai, China, a $2.9 million grant to expand ongoing studies of traditional Chinese medicine in the treatment of cancer. The two institutions will expand their laboratory and clinical studies of herbal and natural-based products as sources for new therapies, acupuncture for relieving disease- and treatment-related side effects and mind-body practices such as qigong for relaxation among breast cancer patients receiving radiation therapy. “Traditional Chinese medicine has a remarkable history,” notes Cohen, “and by applying Western research standards to traditional Chinese medicine, we can better understand possible new applications.”

The awarding of two National Cancer Institute grants is allowing Lorenzo Cohen, Ph.D., and his colleagues to expand their research into the use of traditional Chinese medicine in treating cancer and the benefits of Tibetan Yoga in easing treatment side effects.

‘Operation Stop Cervical Cancer in Nigeria’ Researchers at The University of Texas Center for Biomedical Engineering are bringing technology into remote areas of Africa to save lives. Using a system developed by M. D. Anderson’s Michele Follen, M.D., Ph.D., Rice University’s Rebecca Richards-Kortum, Ph.D. and British Columbia Research Centre’s Calum MacAulay, Ph.D., doctors in Nigeria are providing patients with a quicker, less expensive way to identify cervical cancer. In Africa, cervical cancer is the leading cause of cancer deaths. The device uses a digital colposcope that views the entire cervix and a fiber-optic probe that measures wavelengths of light reflected off the cervix and which can detect cell abnormalities. With a $1 million grant from the ExxonMobil Foundation and generous contributions from philanthropist T. Boone Pickens and Federal Express, six full-service screening centers across Nigeria will be developed. In 2006, Follen and her project team met with regional leaders in Nigeria to evaluate program needs and delivered more than $430,000 worth of medical supplies, equipment and training materials.

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M. D. Anderson Management Committee Members John Mendelsohn, M.D. President Thomas W. Burke, M.D. Executive Vice President and Physician-in-Chief Margaret L. Kripke, Ph.D. Executive Vice President and Chief Academic Officer Leon J. Leach Executive Vice President R. Dan Fontaine, J.D. Senior Vice President for Business Development and Regulatory Affairs Stephen P. Tomasovic, Ph.D. Senior Vice President for Academic Affairs and Vice President for Extramural Programs Ad Interim

Harry R. Gibbs, M.D. Vice President for Institutional Diversity Adrienne C. Lang Vice President for Center Programs Richard E. Champlin, M.D.

Professor and Chair, Department of Stem Cell Transplantation and Cellular Therapy

Mien-Chie Hung, Ph.D.

Professor and Chair, Department of Molecular and Cellular Oncology

Eugenie S. Kleinerman, M.D.

Professor and Head, Division of Pediatrics

M. D. Anderson Faculty Division of Anesthesiology and Critical Care Thomas W. Feeley, M.D. Division Head

D epartment of A nesthesiology and pain medicine David Brown, M.D. Professor and Chair Tayab Andrabi, M.D. Assistant Professor Radha Arunkumar, M.D. Assistant Professor Mohamed Attala, M.D. Professor Krishna Boddu, M.D. Associate Professor Thao P. Bui, M.D. Associate Professor Allen Wade Burton, M.D. Associate Professor Shao-Rui Chen, M.D. Assistant Professor Jeffrey Cerny, M.D. Instructor Joseph S. Chiang, M.D. Professor Lori Dangler, M.D. Assistant Professor Patrick M. Dougherty, Ph.D. Associate Professor Larry C. Driver, M.D. Associate Professor David Ferson, M.D. Professor John C. Frenzel, M.D. Associate Professor Farzin Goravanchi, D.O. Assistant Professor Shannon Michelle Gossett, M.D. Instructor Vijaya Gottumukkala, M.D. Associate Professor Roxana Grasu, M.D. Assistant Professor Howard B. Gutstein, M.D. Associate Professor 42

Basem Hamid, M.D. Assistant Professor Curtis E. Hightower, D.V.M., M.D. Assistant Professor Peter W. Hsu, M.D. Assistant Professor Timothy Albert Jackson, M.D., Ph.D. Assistant Professor Spencer Stephen Kee, M.D. Assistant Professor Debra L. Kennamer, M.D. Professor Alicia M. Kowalski, M.D. Assistant Professor Dhanalakshmi Koyyalagunta, M.D. Associate Professor Piotr A. Kwater, M.D. Assistant Professor Jeffrey Lim, M.D. Instructor Ian Lipski, M.D. Assistant Professor David C. Mackey, M.D. Associate Professor Gabriel Eduardo Mena, M.D. Assistant Professor Kazim Mirza, D.O. Assistant Professor Edward D. Moss, M.D. Professor Linh T. Nguyen, M.D. Assistant Professor Peter H. Norman, M.D. Associate Professor Pascal Owusu-Agyemang, M.D. Assistant Professor Hui-Lin Pan, M.D., Ph.D. Professor Zhizhong Z. Pan, Ph.D. Associate Professor Ronald N. Parris, M.D. Assistant Professor Phillip Cuong Phan, M.D. Assistant Professor Keyuri U. Popat, M.D. Assistant Professor Vivian H. Porche, M.D. Professor

Yury Potylchansky, M.D. Assistant Professor Ronaldo V. Purugganan, M.D. Assistant Professor Tom F. Rahlfs, M.D. Professor Bernhard J.C.J. Riedel, M.D., Ph.D. Associate Professor Marc A. Rozner, Ph.D., M.D. Professor Joseph R. Ruiz, M.D. Assistant Professor Kenneth J. Sapire, M.D. Associate Professor Mona G. Sarkiss, M.D., Ph.D. Assistant Professor Jagtar Singh Heir, D.O. Assistant Professor Jose Soliz, M.D. Instructor Una Srejic, M.D. Assistant Professor Jackson Su, M.D. Assistant Professor Dilip R. Thakar, M.D. Associate Professor Joseph Chao Ting, D.O. Assistant Professor Leonard V. Trapani, M.D. Assistant Professor Angela Truong, M.D. Assistant Professor Dam-Thuy Truong, M.D. Associate Professor Steve Wang, M.D. Instructor Han-Rong Weng, M.D., Ph.D. Assistant Professor Olivier C. Wenker, M.D. Professor

D epartment of C ritical C are Kristen J. Price, M.D. Professor and Chair Gregory H. Botz, M.D. Associate Professor Donna M. Calabrese, M.D. Assistant Professor Karen Chen, M.D. Associate Professor Shao-Rui Chen, M.D. Assistant Professor Diego Hernan de Villalobos, M.D. Assistant Professor Susan Gaeta, M.D. Assistant Professor De Li, M.D. Assistant Professor Imrana Malik, M.D. Assistant Professor Joseph L. Nates, M.D. Associate Professor Selvaraj Egbert Pravinkumar, M.D. Assistant Professor Chad F. Slieper, J.D. Instructor Katherine Wasson, Ph.D. Assistant Professor ad interim

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Division of Cancer Medicine Waun Ki Hong, M.D. Division Head

D epartment of B reast M edical O ncology Gabriel N. Hortobagyi, M.D.

Professor and Chair Banu K. Arun, M.D. Associate Professor Daniel J. Booser, M.D. Professor Aman U. Buzdar, M.D. Professor Massimo Cristofanilli, M.D. Associate Professor Francisco J. Esteva, M.D., Ph.D. Associate Professor Sharon Hermes Giordano, M.D. Assistant Professor Ana Maria Gonzalez-Angulo, M.D. Assistant Professor Marjorie C. Green, M.D. Assistant Professor Karin Marie Hahn, M.D. Assistant Professor Nuhad K. Ibrahim, M.D. Associate Professor Phuong Khanh Morrow, M.D. Assistant Professor Stacy Moulder, M.D. Assistant Professor James L. Murray III, M.D. Professor Rita Nahta, Ph.D. Instructor Lajos Pusztai, M.D., Ph.D. Associate Professor Richard L. Theriault, D.O. Professor Vicente Valero, M.D. Professor Ronald S. Walters, M.D. Professor

D epartment of E xperimental T herapeutics Garth Powis, D.Phil. Professor and Chair Bharat B. Aggarwal, Ph.D. Professor Geoffrey Bartholomeusz, Ph.D. Assistant Professor Robert C. Bast Jr., M.D. Professor Arup Chakraborty, Ph.D. Assistant Professor Bryant G. Darnay, Ph.D. Assistant Professor Suhendan Ekmekcioglu, Ph.D. Assistant Professor Julie A. Ellerhorst, M.D., Ph.D. Associate Professor Zhen Fan, M.D. Associate Professor Izabela Fokt, Ph.D. Instructor

Varsha V. Gandhi, Ph.D. Professor Elizabeth A. Grimm, Ph.D. Professor Walter N. Hittelman, Ph.D. Professor Giuliana J. Izzo, M.D. Assistant Professor Mary Jane Johansen, Pharm.D. Associate Professor Abdul R. Khokhar, Ph.D. Professor Jian Kuang, Ph.D. Associate Professor Razelle Kurzrock, M.D. Professor Betty Lamothe, Ph.D. Instructor Xiaofeng Le, M.D., Ph.D. Assistant Professor Xinqun Li, M.D., Ph.D. Instructor Gabriel Lopez, M.D. Professor Timothy L. Madden, Pharm.D. Associate Professor John S. McMurray, Ph.D. Associate Professor Kapil Mehta, Ph.D. Professor John Mendelsohn, M.D. Professor Khalid Amanali Mohamedali, Ph.D. Instructor Robert A. Newman, Ph.D. Professor Bulent Ozpolat, M.D., Ph.D. Instructor William K. Plunkett Jr., Ph.D. Professor Nancy J. Poindexter, Ph.D. Assistant Professor Waldemar Priebe, Ph.D. Professor Michael G. Rosenblum, Ph.D. Professor Deepa Sampath, Ph.D. Instructor Zahid H. Siddik, Ph.D. Professor Ann Marie Simeone, Ph.D. Instructor Taly Spivak-Kroizman, Ph.D. Assistant Professor Christine Stellrecht, Ph.D. Instructor Ana M. Tari, Ph.D. Associate Professor Ji Yuan Wu, M.D. Instructor Peiying Yang, Ph.D. Assistant Professor Yin H. Yu, M.D. Associate Professor Leonard A. Zwelling, M.D. Professor

D epartment of G astrointestinal M edical O ncology James L. Abbruzzese, M.D.

Professor and Chair Jaffer A. Ajani, M.D. Professor David Z. Chang, M.D., Ph.D. Assistant Professor Cathy Eng, M.D. Assistant Professor Michael J. Fisch, M.D. Associate Professor Katrina Glover, M.D. Assistant Professor Manal M. Hassan, M.D., Ph.D. Assistant Professor Linus Ho, M.D., Ph.D. Assistant Professor David Sanghyun Hong, M.D. Assistant Professor Milind Javle, M.D. Associate Professor Edmund Scott Kopetz, M.D. Assistant Professor Donghui Li, Ph.D. Associate Professor Aung Naing, M.D. Assistant Professor Alexandria Phan, M.D. Assistant Professor Shrikanth A. Reddy, Ph.D. Assistant Professor Melanie B. Thomas, M.D. Assistant Professor Gauri R. Varadhachary, M.D. Associate Professor Daoyan Wei, Ph.D. Instructor Jennifer Jane Wheler, M.D. Assistant Professor Robert A. Wolff, M.D. Associate Professor Keping Xie, M.D., Ph.D. Associate Professor James C. Yao, M.D. Assistant Professor

D epartment of G enitourinary M edical O ncology Christopher J. Logothetis, M.D.

Professor and Chair

Ana Aparicio, M.D. Assistant Professor Wadih Arap, M.D., Ph.D. Professor John Araujo, M.D., Ph.D. Assistant Professor William F. Benedict, M.D. Professor Khoi Chu, Ph.D. Instructor Paul Corn, M.D., Ph.D. Assistant Professor Eric Jonasch, M.D. Assistant Professor Jeri Kim, M.D. Associate Professor Mikhail G. Kolonin, Ph.D. Instructor

Zhi Gang Li, Ph.D. Instructor Paul Mathew, M.D. Assistant Professor Randall E. Millikan, M.D., Ph.D. Associate Professor Monzur Murshed, Ph.D. Instructor ad interim Nora M. Navone, M.D., Ph.D. Associate Professor Lance C. Pagliaro, M.D. Associate Professor Renata Pasqualini, Ph.D. Professor Padmanee Sharma, M.D., Ph.D. Assistant Professor Arlene Odelia Siefker-Radtke, M.D. Assistant Professor Nizar M. Tannir, M.D. Assistant Professor Lawrence Chun Chui Tsao, M.D. Instructor Shi-Ming Tu, M.D. Associate Professor Zhibo Yang, Ph.D. Instructor Xin-Qiao Zhang, M.D., Ph.D. Assistant Professor Jain Zhou, M.D., Ph.D. Assistant Professor

D epartment of G ynecologic M edical oncology Maurie Markman, M.D.

Professor and Chair Ad Interim Siqing Fu, M.D., Ph.D. Assistant Professor Bryan Thomas Joseph Hennessy, M.D. Assistant Professor

D epartment of L eukemia Hagop M. Kantarjian, M.D.

Professor and Chair Miloslav Beran, M.D., Ph.D. Professor Gautam Borthakur, M.B.B.S. Assistant Professor Jan Andreas Burger, M.D. Assistant Professor Jorge E. Cortes-Franco, M.D. Professor Elihu H. Estey, M.D. Professor Zeev Estrov, M.D. Professor Stefan H. Faderl, M.D. Associate Professor Alessandra Ferrajoli, M.D. Assistant Professor Emil J Freireich, M.D. Professor Guillermo Garcia-Manero, M.D. Associate Professor Francis Joseph Giles, M.D. Professor Jean-Pierre Issa, M.D. Professor Jaroslav Jelinek, M.D., Ph.D. Assistant Professor

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Division of Cancer Medicine, continued

Michael J. Keating, M.D. Professor Charles A. Koller, M.D. Professor Shao-Qing Kuang, Ph.D. Instructor Gloria N. Mattiuzzi, M.D. Assistant Professor Susan Oâ&#x20AC;&#x2122;Brien, M.D. Professor Jingxuan Pan, Ph.D. Instructor Farhad Ravandi-Kashani, M.D. Assistant Professor Lanlan Shen, M.D., Ph.D. Assistant Professor Deborah A. Thomas, M.D. Assistant Professor Apostolia Maria Tsimberidou, M.D., Ph.D. Assistant Professor Srdan Verstovsek, M.D. Assistant Professor William G. Wierda, M.D., Ph.D. Assistant Professor

D epartment of Lymphoma / M Y E L O M A Larry W. Kwak, M.D., Ph.D.

Professor and Chair Soung-Chul Cha, Ph.D. Instructor Michelle A. Fanale, M.D. Assistant Professor Luis E. Fayad, M.D. Associate Professor Fredrick B. Hagemeister, M.D. Professor Peter W. McLaughlin, M.D. Professor Sattva S. Neelapu, M.D. Assistant Professor Barbara Pro, M.D. Associate Professor M.A. Rodriguez, M.D. Professor Jorge E. Romaguera, M.D. Professor Felipe Samaniego, M.D. Associate Professor Sheeba Koshy Thomas, M.D. Assistant Professor Michael Wang, M.D. Assistant Professor Suizhao Wang, M.D., Ph.D. Instructor Donna M. Weber, M.D. Associate Professor Qing Yi, M.D., Ph.D. Associate Professor Anas Younes, M.D. Professor

D epartment of M elanoma M edical O ncology Patrick Hwu, M.D.

Professor and Chair

Agop Y. Bedikian, M.D. Professor Luis H. Camacho, M.D. Assistant Professor Wen-Jen Hwu, M.D., Ph.D. Professor

Kevin Bum Soo Kim, M.D. Assistant Professor Gregory A. Lizee, Ph.D. Assistant Professor Willem Overwijk, Ph.D. Assistant Professor Nicholas E. Papadopoulos, M.D. Associate Professor Laszlo Radvanyi, Ph.D. Associate Professor Dapeng Zhou, M.D., Ph.D. Assistant Professor

D epartment of N euro - O ncology W. K. Alfred Yung, M.D.

Professor and Chair Howard Colman, M.D., Ph.D. Assistant Professor Charles A. Conrad, M.D. Associate Professor John Frederick de Groot, M.D. Assistant Professor Arthur D. Forman, M.D. Associate Professor Juan Fueyo-Margareto, M.D. Associate Professor Maria-Magdalena Georgescu, M.D., Ph.D. Associate Professor Mark R. Gilbert, M.D. Professor Candelaria Gomez-Manzano, M.D. Assistant Professor Morris D. Groves Jr., M.D., J.D. Associate Professor Sigmund Huang Hsu, M.D. Assistant Professor Hong Jiang, Ph.D. Instructor Anne E. Kayl, Ph.D. Assistant Professor Dimpy Koul, Ph.D. Assistant Professor Victor A. Levin, M.D. Professor Ta-Jen Liu, Ph.D. Assistant Professor Monica Elena Loghin, M.D. Assistant Professor Zhimin Lu, M.D., Ph.D. Assistant Professor Christina A. Meyers, Ph.D. Professor Irene Newsham, Ph.D. Associate Professor Vinaykumar K. Puduvalli, M.D. Associate Professor John M. Slopis, M.D. Associate Professor Sudhakar Tummala, M.D. Assistant Professor Jeffrey Scott Wefel, Ph.D. Assistant Professor

D epartment of P alliative care and rehabilitation medicine Eduardo Bruera, M.D.

Professor and Chair Shalini Dalal, M.D. Assistant Professor Egidio Del Fabbro, M.D. Assistant Professor Ahmed Elsayem, M.D. Assistant Professor Nada Abdellatif Fadul, M.D. Assistant Professor Moshe Frenkel, M.D. Associate Professor Ying Guo, M.D. Associate Professor Benedict Konzen, M.D. Assistant Professor J. Lynn Palmer, Ph.D. Associate Professor Suresh K. Reddy, M.D. Associate Professor Ki Y. Shin, M.D. Associate Professor Saroj Vadhan, M.D. Professor Paul W. Walker, M.D. Assistant Professor Rajesh R. Yadav, M.D. Assistant Professor Sriram Yennurajalingam, M.D. Assistant Professor Donna S. Zhukovsky, M.D. Associate Professor

D epartment of S arcoma M edical O ncology Robert S. Benjamin, M.D.

Professor and Chair Joseph A. Ludwig, M.D. Assistant Professor Ad Interim Shreyaskumar Patel, M.D. Professor Dejka Marida Steinert, M.D. Assistant Professor Jonathan C. Trent II, M.D., Ph.D. Assistant Professor

D epartment of S tem cell transplantation A N D cellular therapy Richard E. Champlin, M.D.

Professor and Chair

Amin Majid Alousi, M.D. Assistant Professor Paolo Anderlini, M.D. Associate Professor Borje S. Andersson, M.D., Ph.D. Professor Michael Andreeff, M.D., Ph.D. Professor Bing Z. Carter, Ph.D. Assistant Professor Daniel R. Couriel, M.D. Associate Professor Marcos Jose Garcia de Lima, M.D. Associate Professor Sergio A. Giralt, M.D. Professor Chitra Hosing, M.D. Associate Professor Roy Jones, M.D., Ph.D. Professor

Partow Kebriaei, M.D. Assistant Professor Issa F. Khouri, M.D. Professor Krishna V. Komanduri, M.D. Associate Professor Marina Konopleva, M.D., Ph.D. Assistant Professor Martin Korbling, M.D. Professor Steven M. Kornblau, M.D. Associate Professor Xiaoyang Ling, Ph.D. Instructor Sijie Lu, Ph.D. Assistant Professor Qing Ma, Ph.D. Assistant Professor Frank C. Marini III, Ph.D. Assistant Professor John D. McMannis, Ph.D. Professor Jeffrey J. Molldrem, M.D. Professor Yago Nieto, M.D., Ph.D. Associate Professor Uday R. Popat, M.D. Associate Professor Muzaffar H. Qazilbash, M.D. Associate Professor Gabriela Rondon, M.D. Assistant Professor Rima M. Saliba, Ph.D. Assistant Professor Elizabeth Shpall, M.D. Professor Naoto T. Ueno, M.D., Ph.D. Associate Professor Benigno Valdez, Ph.D. Assistant Professor Rui-Yu Wang, M.D., Ph.D. Assistant Professor Eric D. Wieder, Ph.D. Assistant Professor Weiguo Zhang, M.D., Ph.D. Instructor

D epartment of S ystems B iology Gordon B. Mills, M.D., Ph.D.

Professor and Chair

Gabor Balazsi, Ph.D. Assistant Professor Kwai Wa Cheng, Ph.D. Assistant Professor Francois-Xavier Claret, Ph.D. Associate Professor Zhiyong Ding, Ph.D. Instructor Jordan U. Gutterman, M.D. Professor Katherine Stemke Hale, Ph.D. Instructor Valsala Haridas, Ph.D. Assistant Professor Ju-Seog Lee, Ph.D. Assistant Professor Shiaw-Yih Lin, Ph.D. Assistant Professor Yiling Lu, M.D. Assistant Professor Honami Naora, Ph.D. Assistant Professor Prahlad Ram, Ph.D. Assistant Professor Zhi-Xiang Xu, M.D., Ph.D. Assistant Professor

School of F a c u l t y Health Sciences D epartment of T horacic / H ead and N eck M edical O nc O L O G Y Scott M. Lippman, M.D.

Professor and Chair

Maria Behrens, M.D. Instructor George R. Blumenschein, M.D. Assistant Professor Jiong Deng, Ph.D. Instructor Frank V. Fossella, M.D. Professor Bonnie S. Glisson, M.D. Professor Roy S. Herbst, M.D., Ph.D. Professor John Victor Heymach, M.D., Ph.D. Assistant Professor Waun Ki Hong, M.D. Professor Joerg J. Jacoby, Ph.D. Instructor

Faye M. Johnson, M.D., Ph.D. Assistant Professor Daniel D. Karp, M.D. Professor Merrill S. Kies, M.D. Professor Edward S. Kim, M.D. Assistant Professor Woo-Young Kim, Ph.D. Instructor Ja Seok Koo, Ph.D. Assistant Professor Jonathan M. Kurie, M.D. Professor Ho-Young Lee, Ph.D. Associate Professor Reuben Lotan, Ph.D. Professor Charles Lu, M.D. Associate Professor Li Mao, M.D. Professor David G. Menter, Ph.D. Assistant Professor

Yun W. Oh, M.D. Assistant Professor Vassiliki A. Papadimitrakopoulou, M.D. Associate Professor Katherine M. Pisters, M.D. Professor David J. Stewart, M.D. Professor Hai T. Tran, Pharm.D. Assistant Professor Anne Tsao, M.D. Assistant Professor Ralph G. Zinner, M.D. Assistant Professor

Division of Cancer Prevention and Population Sciences Bernard Levin, M.D. Vice President and Division Head

D epartment of B ehavioral S cience Ellen R. Gritz, Ph.D.

Professor and Chair Hoda Badr, Ph.D. Instructor Walter F. Baile, M.D. Professor Karen M. Basen-Engquist, Ph.D. Associate Professor Janice Blalock, Ph.D. Assistant Professor Cindy L. Carmack Taylor, Ph.D. Assistant Professor Brian L. Carter, Ph.D. Assistant Professor Paul M. Cinciripini, Ph.D. Professor Ludmila M. Cofta-Woerpel, Ph.D. Assistant Professor Lorenzo Cohen, Ph.D. Associate Professor Thelma Jean Goodrich, Ph.D. Associate Professor Cho Yan Lam, Ph.D. Instructor Patricia Ann Parker, Ph.D. Assistant Professor Susan K. Peterson, Ph.D. Assistant Professor Alexander V. Prokhorov, M.D., Ph.D. Professor Jason D. Robinson, Ph.D. Instructor Leslie R. Schover, Ph.D. Professor Eileen Huh Shinn, Ph.D. Instructor Damon J. Vidrine, Dr.P.H. Assistant Professor Andrew John Waters, Ph.D. Assistant Professor

D epartment of C linical C ancer P revention Therese Bartholomew Bevers, M.D. Associate Professor Allison Blazek, M.D. Assistant Professor Abenaa Brewster, M.D. Assistant Professor Elise D. Cook, M.D. Assistant Professor Lewis E. Foxhall, M.D. Associate Professor Ashraful M. Hoque, M.D., Ph.D. Assistant Professor Linda C. Hsi, Ph.D. Assistant Professor Anita Lyn Sabichi, M.D. Associate Professor Imad Shureiqi, M.D. Associate Professor Xiaochun Xu, M.D., Ph.D. Associate Professor Xiangsheng Zuo, M.D., Ph.D. Instructor

D epartment of E pidemiology Margaret R. Spitz, M.D.

Professor and Chair Christopher I. Amos, Ph.D. Professor Melissa L. Bondy, Ph.D. Professor Robert M. Chamberlain, Ph.D. Professor Shine Chang, Ph.D. Associate Professor E. Warwick Daw, Ph.D. Assistant Professor Randa El-Zein, M.D., Ph.D. Assistant Professor Carol J. Etzel, Ph.D. Assistant Professor Michele Forman, Ph.D. Professor

Marsha L. Frazier, Ph.D. Professor Ivan P. Gorlov, Ph.D. Instructor Olga Y. Gorlova, Ph.D. Assistant Professor Jian Gu, Ph.D. Assistant Professor Maria A. Hernandez-Valero, Ph.D., Dr.P.H. Instructor Jie Lin, Ph.D. Instructor Somdat Mahabir, Ph.D. Assistant Professor Cielito C. Reyes-Gibby, Dr.P.H. Assistant Professor Michael E. Scheurer, Ph.D. Instructor Sanjay Shete, Ph.D. Associate Professor Sara S. Strom, Ph.D. Associate Professor Li-E Wang, M.D. Instructor Chongjuan Wei, Ph.D. Instructor Qingyi Wei, M.D., Ph.D. Professor Anna Victoria Wilkinson, Ph.D. Instructor Chih-Chieh Wu, Ph.D. Instructor Xifeng Wu, M.D., Ph.D. Professor

M. D. Andersonâ&#x20AC;&#x2122;s School of Health Sciences educates medical support professionals who are in high demand across the United States, awarding bachelorâ&#x20AC;&#x2122;s degrees and certificates in eight allied health programs. Michael J. Ahearn, Ph.D. Dean, School of Health Sciences Christina M. Alapat, M.S. Assistant Professor Mark A. Bailey, M.A. Instructor Shaun T. Caldwell, M.S. Assistant Professor Melissa J. Chapman, M.ED. Assistant Professor Hazel V. Dalton, M.S. Assistant Professor Mahsa Dehghanpour, M.S. Instructor Brandy A. Greenhill, M.S. Instructor Jun Gu, M.D. Instructor Stephanie Ann Hamilton, D.ED. Instructor Vicki L. Hopwood, M.S. Assistant Professor Peter C. Hu, M.S. Assistant Professor DeAnn R. Klein, M.ED. Instructor Patrick Lennon, Ph.D. Instructor Karen J. McClure, M.S. Assistant Professor Suzieann Richards-Bass, M.ED. Instructor Nanci L. Saurdiff, M.ED. Instructor

D epartment of H ealth disparities research David W. Wetter, Ph.D. Professor and Chair Janice A. Chilton, Dr.P.H. Instructor Harry R. Gibbs, M.D. Associate Professor Jennifer Irvin Vidrine, Ph.D. Assistant Professor Lovell A. Jones, Ph.D. Professor Carlos A. Mazas, Ph.D. Instructor Lorna Haughton McNeill, Ph.D. Assistant Professor Isabel Torres, Dr.P.H. Instructor

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Division of Diagnostic Imaging Donald A. Podoloff, M.D. Division Head

D epartment of D iagnostic radiology Reginald F. Munden, M.D., D.M.D.

Professor and Chair Ad Interim Judy Un Chong Ahrar, M.D. Assistant Professor Kamran Ahrar, M.D. Associate Professor Elsa Arribas, M.D. Assistant Professor Rony Avritscher, M.D. Assistant Professor Aparna Balachandran, M.D. Assistant Professor Deepak G. Bedi, M.D. Professor Priya R. Bhosale, M.D. Assistant Professor Yulia Bronstein, M.D. Assistant Professor John Bruzzi, M.D. Assistant Professor Chusilp Charnsangavej, M.D. Professor Marvin H. Chasen, M.D. Professor Tzehping Linda Chi, M.D. Associate Professor Haesun Choi, M.D. Associate Professor Colleen Costelloe, M.D. Assistant Professor Cynthia L. David, M.D. Professor Paul L. Davis, M.D. Associate Professor James Matthew Debnam, M.D. Assistant Professor Peter J. Dempsey, M.D. Professor Catherine Ellen Devine, M.D. Assistant Professor Mark J. Dryden, M.D. Associate Professor Ronelle A. DuBrow, M.D. Professor Joel S. Dunnington, M.D. Associate Professor Beth S. Edeiken-Monroe, M.D. Professor Farzin Eftekhari, M.D. Professor Jeremy Erasmus Jr., M.D. Professor Bruno D. Fornage, M.D. Professor Lawrence E. Ginsberg, M.D. Professor Gregory Gladish, M.D. Associate Professor Monica Andrea Gonzalez-De Luna, M.D. Assistant Professor Sanjay Gupta, M.D. Associate Professor Leena Mirjami Hamberg, Ph.D. Associate Professor Tamara Miner Haygood, M.D., Ph.D. Assistant Professor

Marshall E. Hicks, M.D. Professor George J. Hunter, M.D. Associate Professor Revathy B. Iyer, M.D. Associate Professor Zuxing Kan, M.D., Ph.D. Associate Professor Harmeet Kaur, M.D. Assistant Professor Leena Ketonen, M.D., Ph.D. Professor Andras Konya, Ph.D. Associate Professor Ashok J. Kumar, M.D. Professor Rajendra Kumar, M.D. Professor Vikas Kundra, M.D., Ph.D. Assistant Professor Deanna Lynn Lane, M.D. Assistant Professor Elizabeth A. Lano, M.D. Associate Professor Huong Le-Petross, M.D. Assistant Professor Evelyne M. Loyer, M.D. Professor John E. Madewell, M.D. Professor David Madoff, M.D. Assistant Professor Armeen Mahvash, M.D. Assistant Professor Leonardo Pimental Marcal, M.D. Assistant Professor Edith M. Marom, M.D. Associate Professor Aurelio Matamoros Jr., M.D. Professor Kevin W. McEnery, M.D. Professor Stephen E. McRae, M.D. Assistant Professor William A. Murphy Jr., M.D. Professor Ravi Murthy, M.D. Associate Professor Chaan Soong Ng, M.D. Associate Professor Paul Oâ&#x20AC;&#x2122;Sullivan, M.D. Assistant Professor Suhas Parulekar, M.D. Professor Madhavi Patnana, M.D. Assistant Professor Bharat Raval, M.D. Professor Bradley Sabloff, M.D. Associate Professor Barry I. Samuels, M.D. Professor Carl Sandler, M.D. Professor Dawid Schellingerhout, M.D. Assistant Professor Komal Shah, M.D. Assistant Professor Paul M. Silverman, M.D. Professor Tanya Stephens, M.D. Assistant Professor

Janio Szklaruk, M.D. Associate Professor Alda Lui Tam, M.D. Assistant Professor Eric P. Tamm, M.D. Associate Professor Mylene Truong, M.D. Associate Professor Datla G. Varma, M.D. Professor Chitra Viswanathan, M.D. Assistant Professor Michael J. Wallace, M.D. Associate Professor Gary J. Whitman, M.D. Associate Professor Kenneth C. Wright, Ph.D. Professor Wei Yang, M.D. Associate Professor

D epartment of E xperimental diagnostic imaging Juri G. Gelovani, M.D., Ph.D.

Professor and Chair

Mian Alauddin, Ph.D. Associate Professor Hossain Baghaei, Ph.D. Assistant Professor William G. Bornmann, Ph.D. Professor Victor Krasnykh, Ph.D. Associate Professor Chun Li, Ph.D. Professor Hongdi Li, Ph.D. Assistant Professor Amer Najjar, Ph.D. Instructor Sabrina M. Ronen, Ph.D. Associate Professor Ping-Yiu Tong, Ph.D. Professor Yu Wang, Ph.D. Instructor Wai-Hoi Wong, Ph.D. Professor David J. Yang, Ph.D. Associate Professor

D epartment of I maging P hysics John D. Hazle, Ph.D.

Professor and Chair James A. Bankson, Ph.D. Assistant Professor Luc Bidaut, Ph.D. Associate Professor Dianna Cody, Ph.D. Associate Professor Richard L. Holmes, Ph.D. Associate Professor Edward F. Jackson, Ph.D. Professor Aaron Kyle Jones, Ph.D. Instructor Chao-Jen Lai, Ph.D. Instructor

Xinming Liu, Ph.D. Assistant Professor Jingfei Ma, Ph.D. Associate Professor Srikanth Mahankali, M.D. Assistant Professor Osama Mawlawi, Ph.D. Associate Professor Tinsu Pan, Ph.D. Associate Professor Xiujiang Rong, Ph.D. Assistant Professor Chris C. Shaw, Ph.D. Professor Jason Stafford, Ph.D. Assistant Professor Jihong Wang, Ph.D. Associate Professor Richard Wendt III, Ph.D. Associate Professor Charles E. Willis, Ph.D. Associate Professor

D epartment of nuclear medicine Homer A. Macapinlac, M.D. Associate Professor and Chair Ad Interim Beth Chasen, M.D. Instructor Isis W. Gayed, M.D. Assistant Professor E. Edmund Kim, M.D. Professor Rodolfo F. Nunez, M.D. Assistant Professor Donald A. Podoloff, M.D. Professor Franklin C. Wong, M.D., Ph.D., J.D. Associate Professor Henry Yeung, M.D. Associate Professor

F a c u l t y

Division of Internal Medicine Robert F. Gagel, M.D. Division Head

D epartment of C ardiology Edward T. Yeh, M.D.

Professor and Chair John Christopher Champion, M.D. Assistant Professor Jinke Cheng, Ph.D. Assistant Professor Jean-Bernard Durand, M.D. Assistant Professor Michael S. Ewer, M.D. Professor Limin Gong, Ph.D. Assistant Professor Tetsu Kamitani, M.D., Ph.D. Associate Professor Aarif Y. Khakoo, M.D. Assistant Professor Daniel J. Lenihan, M.D. Associate Professor Juan Carlos Plana, M.D. Assistant Professor ad interim Joseph Swafford, M.D. Professor Syed Wamique Yusuf, M.D. Assistant Professor Sui Zhang, M.D., Ph.D. Instructor

D epartment of D ermatology Ronald P. Rapini, M.D.

Professor and Chair Susan Chon, M.D. Assistant Professor Carol R. Drucker, M.D. Associate Professor Madeleine Duvic, M.D. Professor Parul Hazarika, Ph.D. Assistant Professor Sharon R. Hymes, M.D. Professor Deborah Mac Farlane, M.D. Associate Professor Michael R. Migden, M.D. Assistant Professor Tri Nguyen, M.D. Associate Professor Xiao Ni, M.D., Ph.D. Instructor Chun-Lei Zhang, M.D., Ph.D. Instructor

D epartment of E ndocrine N eoplasia and H ormonal D isorders Steven I. Sherman, M.D.

Professor and Chair Naifa L. Busaidy, M.D. Assistant Professor Gilbert Cote, Ph.D. Associate Professor Camilo Jimenez, M.D. Assistant Professor Victor R. Lavis, M.D. Professor Sara Peleg, Ph.D. Associate Professor Rena V. Sellin, M.D. Professor Pankaj Shah, M.D. Assistant Professor Steven G. Waguespack, M.D. Assistant Professor

D epartment of G astrointestinal M edicine and N utrition John R. Stroehlein, M.D.

Professor and Chair Ad Interim

Sharmila Anandasabapathy, M.D. Assistant Professor Robert S. Bresalier, M.D. Professor James Byrd, Ph.D. Associate Professor Marta Davila, M.D. Associate Professor Alexander A. Dekovich, M.D. Associate Professor Sushovan Guha, M.D., Ph.D. Assistant Professor Jeffrey H. Lee, M.D. Associate Professor Bernard Levin, M.D. Professor Patrick M. Lynch, M.D., J.D. Associate Professor Nachman Mazurek, Ph.D. Assistant Professor William A. Ross, M.D. Associate Professor Shumei Song, M.D., Ph.D. Instructor

D epartment of G eneral I nternal M edicine , A mbulatory T reatment and E mergency C are Carmelita P. Escalante, M.D.

Professor and Chair Javier P. Berrios Rivera, M.D. Assistant Professor Maria E. Cabanillas, M.D. Assistant Professor Shuwei Gao, M.D. Assistant Professor Anna D. Giocondo, M.D. Assistant Professor Carmen E. Gonzalez, M.D. Assistant Professor

Tejpal Grover, M.D. Associate Professor Jerry Don Henderson, M.D. Instructor Jessica P. Hwang, M.D. Assistant Professor Amit Lahoti, M.D. Assistant Professor Wenli Liu, M.D. Assistant Professor Huifang Lu, M.D., Ph.D. Assistant Professor Ellen F. Manzullo, M.D. Professor Mary Merkle, M.D. Assistant Professor Stephanie B. Mundy, M.D. Assistant Professor Lonzetta Newman, M.D. Assistant Professor Jeong Hoon Oh, M.D. Assistant Professor John T. Patlan, M.D. Assistant Professor Margaret B. Row, M.D. Assistant Professor Sunil K. Sahai, M.D. Assistant Professor Abdulla K. Salahudeen, M.D. Professor Maria Suarez-Almazor, M.D., Ph.D. Professor Marieberta Vidal, M.D. Instructor Khanh D. Vu, M.D. Assistant Professor Jason Robert Westin, M.D. Instructor Sai-Ching Jim Yeung, M.D., Ph.D. Associate Professor

D epartment of I nfectious D iseases , I nfection C ontrol and E mployee H ealth

D epartment of P ulmonary M edicine Burton F. Dickey, M.D.

Professor and Chair Roberto Adachi, M.D. Assistant Professor Diwakar Balachandran, M.D. Assistant Professor Lara Bashoura, M.D. Assistant Professor Georgie A. Eapen, M.D. Assistant Professor Scott Evans, M.D. Assistant Professor Christopher M. Evans, Ph.D. Assistant Professor Carlos Jimenez, M.D. Assistant Professor Rodolfo C. Morice, M.D. Professor Vickie R. Shannon, M.D. Professor Michael J. Tuvim, Ph.D. Associate Professor

D epartment of S ymptom R esearch Charles S. Cleeland, Ph.D. Professor and Chair Karen O. Anderson, Ph.D. Assistant Professor Tito R. Mendoza, Ph.D. Assistant Professor Guadalupe Palos, Dr.P.H. Assistant Professor Qiuling Shi, Ph.D. Instructor Xin Wang, M.D. Associate Professor Loretta A. Williams, D.S.N. Instructor

Issam I. Raad, M.D.

Professor and Chair

Javier A. Adachi, M.D. Assistant Professor Roy F. Chemaly, M.D. Assistant Professor Elizabeth Conrad Frenzel, M.D. Assistant Professor Ray Y. Hachem, M.D. Assistant Professor Dimitrios P. Kontoyiannis, M.D. Professor Victor Eduardo Mulanovich, M.D. Assistant Professor Kenneth V. Rolston, M.D. Professor Amar Safdar, M.D. Associate Professor Georgia A. Thomas, M.D. Associate Professor

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Division of Pathology and Laboratory Medicine Stanley R. Hamilton, M.D. Division Head

D epartment of H ematopathology L. Jeffrey Medeiros, M.D.

Professor and Chair Lynne Abruzzo, M.D., Ph.D. Associate Professor Joan H. Admirand, M.D. Assistant Professor Hesham Amin, M.D. Assistant Professor Carlos E. Bueso-Ramos, M.D., Ph.D. Associate Professor Richard J. Ford Jr., M.D., Ph.D. Professor Yang O. Huh, M.D. Professor Daniel M. Jones, M.D., Ph.D. Associate Professor Jeffrey L. Jorgensen, M.D., Ph.D. Assistant Professor Sergej Naumovich Konoplev, M.D., Ph.D. Assistant Professor Ming-Sheng Lee, M.D. Associate Professor Bang-Ning Lee, Ph.D. Assistant Professor Pei Lin, M.D. Associate Professor Rajyalaksh Luthra, Ph.D. Associate Professor John T. Manning, M.D. Professor Georgios Zaharias Rassidakis, M.D., Ph.D. Assistant Professor James M. Reuben, Ph.D. Associate Professor Mark J. Routbort, M.D., Ph.D. Assistant Professor Ellen J. Schlette, M.D. Assistant Professor Francisco Vega-Vazquez, M.D., Ph.D. Assistant Professor Cheng Cameron Yin, M.D., Ph.D. Assistant Professor Mingjian James You, M.D., Ph.D. Assistant Professor

D epartment of L aboratory M edicine Benjamin Lichtiger, M.D., Ph.D.

Professor and Chair

Pedro Cano, M.D. Associate Professor Su S. Chen, M.D. Assistant Professor Marcelo Fernandez-Vina, Ph.D. Professor Herbert A. Fritsche Jr., Ph.D. Professor Xiang-Yang Han, M.D., Ph.D. Associate Professor Xin Han, M.D. Assistant Professor Beverly Carol Handy, M.D. Assistant Professor Cheryl F. Hirsch-Ginsberg, M.D. Associate Professor Paul LaSala, M.D. Assistant Professor Gregory May, Ph.D. Professor 48

Aida B. Narvios, M.D. Assistant Professor Luis E. Remus III, M.D., Ph.D. Assistant Professor Kathleen J. Sazama, M.D., J.D. Professor Kurt Clement Sizer, M.D. Assistant Professor Xiaoping Sun, M.D., Ph.D. Assistant Professor Jeffrey J. Tarrand, M.D. Associate Professor

D epartment of M olecular P athology Ralph B. Arlinghaus, Ph.D.

Professor and Chair

Eckhard Alt, M.D. Professor Martin Campbell, Ph.D. Associate Professor Kun-Sang Chang, Ph.D. Associate Professor Jiale Dai, Ph.D. Assistant Professor Peter R. Gascoyne, Ph.D. Professor Anwar Hossain, Ph.D. Instructor Peng Huang, M.D., Ph.D. Associate Professor Ryuji Kobayashi, Ph.D. Professor Macus T. Kuo, Ph.D. Professor Yu-Chen Lee, Ph.D. Assistant Professor Xiaohong Leng, Ph.D. Instructor Zhengdong Liang, M.D., Ph.D. Instructor Yong Liao, Ph.D. Assistant Professor Sue-Hwa Lin, Ph.D. Professor Timothy J. McDonnell, M.D., Ph.D. Professor Helene Pelicano, Ph.D. Instructor Ajoy Kumar Samanta, Ph.D. Assistant Professor Subrata Sen, Ph.D. Associate Professor Yao-Hua Song, M.D., Ph.D. Associate Professor Jody V. Vykoukal, Ph.D. Instructor Xiangcang Ye, Ph.D. Instructor

D epartment of P athology Janet M. Bruner, M.D.

Professor and Chair

Constance Albarracin, M.D., Ph.D. Assistant Professor Kenneth D. Aldape, M.D. Associate Professor Krishna Bhat, Ph.D. Instructor ad interim Russell Broaddus, M.D., Ph.D. Associate Professor Nancy P. Caraway, M.D. Associate Professor Bogdan A. Czerniak, M.D., Ph.D. Professor Michael T. Deavers, M.D. Associate Professor

Abdul Hafeez Diwan, M.D., Ph.D. Assistant Professor Mary Elizabeth Edgerton, M.D., Ph.D. Associate Professor Adel K. El-Naggar, M.D., Ph.D. Professor Elizabeth Dierksen Euscher, M.D. Assistant Professor Harry L. Evans, M.D. Professor Tina V. Fanning, M.D. Professor Gregory N. Fuller, M.D., Ph.D. Professor Michael Gilcrease, M.D., Ph.D. Associate Professor Yun Gong, M.D. Assistant Professor Charles Chuanhai Guo, M.D. Assistant Professor Ming Guo, M.D. Assistant Professor Lei Huo, M.D., Ph.D. Assistant Professor Doina Ivan, M.D. Assistant Professor Ruth L. Katz, M.D. Professor Savitri Krishnamurthy, M.D. Associate Professor Lauren A. Langford, M.D. Associate Professor Alexander Lazar, M.D., Ph.D. Assistant Professor Jinsong Liu, M.D., Ph.D. Associate Professor Anais Malpica, M.D. Professor Dipen Maheshbhai Maru, M.D. Assistant Professor ad interim Kanchana Natarajan Mendes, Ph.D. Instructor Lavinia P. Middleton, M.D. Associate Professor

Cesar Moran, M.D. Professor Jason William Nash, D.O. Assistant Professor Nelson G. Ordonez, M.D. Professor Victor Prieto, M.D., Ph.D. Professor Asif Rashid, M.D., Ph.D. Associate Professor Austin K. Raymond, M.D. Associate Professor Erika Resetkova, M.D., Ph.D. Assistant Professor Michael Warren Riben, M.D. Assistant Professor Aysegul A. Sahin, M.D. Professor Nour Sneige, M.D. Professor Gregg A. Staerkel, M.D. Professor John Stewart, M.D., Ph.D. Assistant Professor William F. Symmans, M.D. Associate Professor Pheroze Tamboli, M.D. Associate Professor Dongfeng Tan, M.D. Associate Professor Patricia Troncoso, M.D. Professor Huamin Wang, M.D., Ph.D. Assistant Professor Michelle Dianne Williams, M.D. Assistant Professor Ignacio Ivan Wistuba, M.D. Associate Professor Yun Wu, M.D., Ph.D. Assistant Professor Gong Yang, Ph.D. Instructor Wei Zhang, Ph.D. Professor

Division of Pediatrics Eugenie S. Kleinerman, M.D. Division Head

D epartment of P ediatrics Eugenie S. Kleinerman, M.D.

Professor and Chair

Peter Anderson, M.D., Ph.D. Professor Martha Askins, Ph.D. Assistant Professor Joann L. Ater, M.D. Professor Joya Chandra, Ph.D. Assistant Professor Laurence Cooper, M.D., Ph.D. Associate Professor Seth Corey, M.D. Professor Jose Antonio Cortes, M.D. Instructor Alan Fields, M.D. Professor Anna Rachel Franklin, M.D. Assistant Professor Vidya Gopalakrishnan, Ph.D. Assistant Professor Cynthia E. Herzog, M.D. Associate Professor William K. Hoots, M.D. Professor

Dennis Hughes, M.D., Ph.D. Assistant Professor Winston Huh, M.D. Assistant Professor Carroll King, M.D., J.D. Assistant Professor Nadezhda V. Koshkina, Ph.D. Assistant Professor Dean A. Lee, M.D., Ph.D. Assistant Professor Rodrigo Mejia, M.D. Associate Professor Bartlett D. Moore, Ph.D. Professor Cesar Augusto Nunez, M.D. Assistant Professor Demetrios Petropoulos, M.D. Assistant Professor Rhonda Robert, Ph.D. Associate Professor Michael E. Rytting, M.D. Assistant Professor Robert J. Wells, M.D. Professor Johannes Wolff, M.D. Professor Laura L. Worth, M.D., Ph.D. Associate Professor Peter Eric Zage, M.D., Ph.D. Assistant Professor Patrick A. Zweidler-McKay, M.D., Ph.D. Assistant Professor

F a c u l t y

Division of Quantitative Sciences Donald Berry, Ph.D. Division Head

D epartment of bioinformatics and comp U T A T I O N A L biology Bradley McIntosh Broom, Ph.D.

Associate Professor and Chair Ad Interim Jonas Silva Almeida, Ph.D. Professor Keith A. Baggerly, Ph.D. Associate Professor Kevin R. Coombes, Ph.D. Associate Professor Jianhua Hu, Ph.D. Assistant Professor Yuan Ji, Ph.D. Assistant Professor Shoudan Liang, Ph.D. Professor Mandri N. Obeyesekere, Ph.D. Associate Professor Romesh C. Stanislaus, Ph.D. Instructor David Stivers, Ph.D. Assistant Professor

Susan L. Tucker, Ph.D. Professor Jing Wang, Ph.D. Instructor Li Zhang, Ph.D. Assistant Professor Ming Zhang, Ph.D. Assistant Professor

D epartment of biostatistics Donald Berry, Ph.D.

Professor and Chair Edward N. Atkinson, Ph.D. Professor Veerabhadran Baladandayuthapani, Ph.D. Assistant Professor Benjamin Nebiyou Bekele, Ph.D. Associate Professor Scott B. Cantor, Ph.D. Associate Professor Kim-Anh Do, Ph.D. Professor Linda S. Elting, Dr.P.H. Professor

Kenneth R. Hess, Ph.D. Associate Professor Xuelin Huang, Ph.D. Assistant Professor Valen E. Johnson, Ph.D. Professor Jiun-Kae Jack Lee, Ph.D. Professor Yisheng Li, Ph.D. Assistant Professor Jeffrey Morris, Ph.D. Associate Professor Peter Mueller, Ph.D. Professor Gary L. Rosner, Sc.D. Professor Yu Shen, Ph.D. Professor Ya-Chen Shih, Ph.D. Associate Professor Richard J. Swartz, Ph.D. Instructor Peter F. Thall, Ph.D. Professor Guosheng Yin, Ph.D. Assistant Professor Ying Yuan, Ph.D. Assistant Professor

Division of Radiation Oncology James D. Cox, M.D. Division Head

D epartment of E xperimental R adiation O ncology Raymond E. Meyn Jr., Ph.D.

Professor and Chair Ad Interim Said Akli, Ph.D. Assistant Professor Ekem T. Efuet, Ph.D. Instructor Khandan Keyomarsi, Ph.D. Professor Lei Li, Ph.D. Associate Professor Kathryn A. Mason, M.Sc. Associate Professor Marvin L. Meistrich, Ph.D. Professor Luka Milas, M.D., Ph.D. Professor Anupama Munshi, Ph.D. Assistant Professor Uma Raju, Ph.D. Assistant Professor Gunapala Shetty, Ph.D. Assistant Professor Nicholas H. Terry, Ph.D. Associate Professor Elizabeth L. Travis, Ph.D. Professor Xin Wang, Ph.D. Instructor Rozita Yarmand, Ph.D. Assistant Professor

D epartment of R adiation O ncology James D. Cox, M.D.

Professor and Chair Anesa Ahamad, M.D. Assistant Professor

Kie-Kian Ang, M.D., Ph.D. Professor M. Kara Bucci, M.D. Assistant Professor Thomas A. Buchholz, M.D. Professor Eric L. Chang, M.D. Associate Professor Joe Y. Chang, M.D., Ph.D. Assistant Professor K. Clifford Chao, M.D. Associate Professor Rex Min Cheung, M.D., Ph.D. Assistant Professor Seungtaek Choi, M.D. Assistant Professor Christopher Crane, M.D. Associate Professor Bouthaina Shbib Dabaja, M.D. Assistant Professor Prajnan Das, M.D. Assistant Professor Marc E. Delclos, M.D. Associate Professor Patricia J. Eifel, M.D. Professor Steven J. Frank, M.D. Assistant Professor Adam S. Garden, M.D. Professor Beverly Ashleigh Guadagnolo, M.D. Assistant Professor Thomas M. Guerrero, M.D., Ph.D. Assistant Professor Nora A. Janjan, M.D. Professor Melenda Jeter, M.D. Assistant Professor Anuja Jhingran, M.D. Associate Professor Ritsuko Komaki, M.D. Professor David G. Kornguth, M.D. Assistant Professor Sunil Krishnan, M.D. Assistant Professor Deborah A. Kuban, M.D. Professor

Andrew K. Lee, M.D. Assistant Professor Zhongxing Liao, M.D. Associate Professor Anita Mahajan, M.D. Associate Professor Mary Frances McAleer, M.D., Ph.D. Assistant Professor William H. Morrison, M.D. Associate Professor Julia L. Oh, M.D. Assistant Professor Michael Oâ&#x20AC;&#x2122;Reilly, M.D. Assistant Professor Christopher E. Pelloski, M.D. Assistant Professor George H. Perkins, M.D. Assistant Professor David Rosenthal, M.D. Associate Professor David L. Schwartz, M.D. Assistant Professor Eric A. Strom, M.D. Professor Welela Tereffe, M.D. Assistant Professor Shiao Y. Woo, M.D. Professor Wendy Woodward, M.D., Ph.D. Assistant Professor Tse-Kuan Yu, M.D., Ph.D. Assistant Professor Gunar K. Zagars, M.D. Professor

D epartment of R adiation P hysics Radhe Mohan, Ph.D.

Professor and Chair

Bijan Arjomandy, Ph.D. Assistant Professor Peter A. Balter, Ph.D. Assistant Professor Abdou Samad Beddar, Ph.D. Associate Professor

Jose A. Bencomo, Ph.D. Associate Professor Tina Marie Briere, Ph.D. Instructor Martin Bues, Ph.D. Instructor George Ciangaru, Ph.D. Instructor Lei Dong, Ph.D. Associate Professor Weiliang Du, Ph.D. Instructor David S. Followill, Ph.D. Associate Professor Kent A. Gifford, Ph.D. Instructor Michael Gillin, Ph.D. Professor Sandeep Hunjan, Ph.D. Assistant Professor Geoffrey Ibbott, Ph.D. Professor Rajat J. Kudchadker, Ph.D. Assistant Professor Ruijie Rachel Liu, Ph.D. Instructor Dershan Luo, Ph.D. Instructor Mary K. Martel, Ph.D. Professor Dragan Mirkovic, Ph.D. Assistant Professor Firas Mourtada, Ph.D. Assistant Professor Wayne D. Newhauser, Ph.D. Assistant Professor Jerimy Clifford Polf, Ph.D. Instructor Karl L. Prado, Ph.D. Associate Professor Narayan Sahoo, Ph.D. Associate Professor Mohammad Salehpour, Ph.D. Associate Professor Almon S. Shiu, Ph.D. Professor Alfred R. Smith, Ph.D. Professor George Starkschall, Ph.D. Professor Marilyn Stovall, Ph.D. Professor Ramesh C. Tailor, Ph.D. Assistant Professor Uwe Titt, Ph.D. Assistant Professor Oleg N. Vassiliev, Ph.D. Assistant Professor Sastry Vedam, Ph.D. Assistant Professor Milos Vicic, Ph.D. Assistant Professor Congjun Wang, Ph.D. Instructor He Wang, Ph.D. Instructor Xiaochun Wang, Ph.D. Instructor James N. Yang, Ph.D. Assistant Professor Sean X. Zhang, Ph.D. Assistant Professor Xiaodong Zhang, Ph.D. Assistant Professor Xiaorong Ronald Zhu, Ph.D. Associate Professor 49

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Division of Surgery Raphael E. Pollock, M.D., Ph.D. Division Head

D epartment of G ynecologic O ncology David M. Gershenson, M.D.

Professor and Chair Michael W. Bevers, M.D. Associate Professor Diane C. Bodurka, M.D. Associate Professor Jubilee Brown, M.D. Assistant Professor Thomas W. Burke, M.D. Professor Robert Coleman, M.D. Professor Ralph S. Freedman, M.D., Ph.D. Professor Michael Frumovitz, M.D. Assistant Professor Wei Hu, M.D., Ph.D. Assistant Professor Constantin Ioannides, Ph.D. Professor John J. Kavanagh, M.D. Professor Elizabeth R. Keeler, M.D. Assistant Professor Gokhan Kilic, M.D. Assistant Professor Charles F. Levenback, M.D. Professor Karen H. Lu, M.D. Associate Professor Andrea Milbourne, M.D. Associate Professor Pedro Tomas Ramirez, M.D. Associate Professor Lois M. Ramondetta, M.D. Associate Professor Helen E. Rhodes, M.D. Assistant Professor Rosemarie Schmandt, Ph.D. Assistant Professor Judith Ann Smith, Pharm.D. Assistant Professor Anil K. Sood, M.D. Professor George Stancel, Ph.D. Professor Charlotte C. Sun, Dr.P.H. Assistant Professor James T. Wharton, M.D. Professor Judith K. Wolf, M.D. Associate Professor Kwong K. Wong, Ph.D. Associate Professor

D epartment of H ead and N eck S urgery Randal S. Weber, M.D.

Professor and Chair

Geetika Chakravarty, Ph.D. Instructor Mark S. Chambers, D.M.D. Associate Professor Gary L. Clayman, M.D., D.D.S. Professor Eduardo M. Diaz Jr., M.D. Associate Professor 50

Bita Esmaeli, M.D. Associate Professor Mitchell J. Frederick, Ph.D. Assistant Professor Paul W. Gidley, M.D. Associate Professor Ann Marie Gillenwater, M.D. Associate Professor Dan S. Gombos, M.D. Assistant Professor Ehab Y. Hanna, M.D. Professor Amy Clark Hessel, M.D. Assistant Professor F. Christopher Holsinger, M.D. Assistant Professor Sheikh M. Ismail, Ph.D. Assistant Professor Rhonda F. Jacob, D.D.S. Professor Arumugam Jayakumar, Ph.D. Assistant Professor Stella K. Kim, M.D. Assistant Professor Michael Elliot Kupferman, M.D. Assistant Professor Jan S. Lewin, Ph.D. Associate Professor Guojun Li, M.D., Ph.D. Assistant Professor Jack W. Martin, D.D.S. Professor Abhijit Mazumdar, Ph.D. Instructor Jeffrey N. Myers, M.D., Ph.D. Professor Jade S. Schiffman, M.D. Professor Erich M. Sturgis, M.D. Associate Professor Bela B. Toth, D.D.S. Professor Xiangwei Wu, Ph.D. Associate Professor Tongxin Xie, M.D., Ph.D. Instructor Ge Zhou, Ph.D. Instructor

Sujit S. Prabhu, M.D. Assistant Professor Ganesh Rao, M.D. Assistant Professor Laurence D. Rhines, M.D. Associate Professor Dima Suki, Ph.D. Associate Professor Jeffrey Weinberg, M.D. Assistant Professor

D epartment of N eurosurgery

Eddie K. Abdalla, M.D. Assistant Professor Frederick C. Ames, M.D. Professor Gildy Babiera, M.D. Assistant Professor Isabelle Bedrosian, M.D. Assistant Professor Ervin B. Brown, M.D. Associate Professor Christopher P. Cannon, M.D. Assistant Professor George J. Chang, M.D. Assistant Professor Paul J. Chiao, Ph.D. Associate Professor Janice Nicole Cormier, M.D. Assistant Professor Steven A. Curley, M.D. Professor Lee M. Ellis, M.D. Professor Douglas B. Evans, M.D. Professor Barry W. Feig, M.D. Professor

Raymond Sawaya, M.D.

Professor and Chair Oliver Bogler, Ph.D. Associate Professor Franco DeMonte, M.D. Professor Samuel J. Hassenbusch III, M.D., Ph.D. Professor Amy B. Heimberger, M.D. Assistant Professor Suyun Huang, Ph.D. Assistant Professor Seiji Kondo, M.D., Ph.D. Associate Professor Yasuko Kondo, M.D., Ph.D. Assistant Professor Frederick F. Lang Jr., M.D. Professor Ian E. McCutcheon, M.D. Professor Sandip Kumar Mishra, Ph.D. Instructor

D epartment of plastic surgery Geoffrey L. Robb, M.D.

Professor and Chair Donald P. Baumann, M.D. Assistant Professor Elisabeth K. Beahm, M.D. Associate Professor Charles E. Butler, M.D. Associate Professor David W. Chang, M.D. Professor Pierre Chevray, M.D., Ph.D. Associate Professor Melissa Ann Crosby, M.D. Assistant Professor Matthew M. Hanasono, M.D. Assistant Professor Steven Kronowitz, M.D. Associate Professor Michael J. Miller, M.D. Professor Scott Oates, M.D. Associate Professor Greg P. Reece, M.D. Professor Roman Skoracki, M.D. Assistant Professor Peirong Yu, M.D. Associate Professor

D epartment of S urgical O ncology Raphael E. Pollock, M.D., Ph.D.

Professor and Chair

Jason B. Fleming, M.D. Associate Professor Jeffrey E. Gershenwald, M.D. Associate Professor Michael Jennings Gray, Ph.D. Instructor Andrea Hayes-Jordan, M.D. Assistant Professor Kelly K. Hunt, M.D. Professor Rosa Frances Hwang, M.D. Assistant Professor Henry Mark Kuerer, M.D., Ph.D. Associate Professor Laura Ann Lambert, M.D. Assistant Professor Jeffrey E. Lee, M.D. Professor Valerae O. Lewis, M.D. Associate Professor Zhongkui Li, Ph.D. Instructor Patrick P. Lin, M.D. Associate Professor Jianhua Ling, Ph.D. Instructor Anthony Lucci, M.D. Associate Professor Paul F. Mansfield, M.D. Professor Funda Meric-Bernstam, M.D. Associate Professor Bailu Peng, Ph.D. Instructor Nancy Dugal Perrier, M.D. Associate Professor Peter W. Pisters, M.D. Professor Miguel A. Rodriguez-Bigas, M.D. Professor Merrick I. Ross, M.D. Professor Balraj Singh, Ph.D. Assistant Professor S. Eva Singletary, M.D. Professor John M. Skibber, M.D. Professor Jean Nicolas Vauthey, M.D. Professor

D epartment of thoracic and cardiovascular surgery Stephen G. Swisher, M.D.

Professor and Chair Arlene M. Correa, Ph.D. Assistant Professor Wuguo Deng, Ph.D. Instructor Bingliang Fang, M.D., Ph.D. Associate Professor Wayne L. Hofstetter, M.D. Assistant Professor Lin Ji, Ph.D. Associate Professor Reza John Mehran, M.D. Associate Professor Abujiang Pataer, M.D., Ph.D. Assistant Professor

F a c u l t y Rick Peng, M.D. Instructor ad interim Rajagopal Ramesh, Ph.D. Associate Professor David C. Rice, M.D. Associate Professor Jack A. Roth, M.D. Professor Ara A. Vaporciyan, M.D. Associate Professor Garrett L. Walsh, M.D. Professor

D epartment of urology Colin P. N. Dinney, M.D.

Professor and Chair Liana Adam, M.D., Ph.D. Assistant Professor Richard J. Babaian, M.D. Professor Joseph N. Corriere Jr., M.D. Professor John W. Davis, M.D. Assistant Professor H. Barton Grossman, M.D. Professor

Ashish Kamat, M.D. Assistant Professor Surena Matin, M.D. Assistant Professor Hiroyuki Nakanishi, M.D. Assistant Professor Curtis A. Pettaway, M.D. Professor Louis L. Pisters, M.D. Professor John F. Ward, M.D. Assistant Professor Ouida Lenaine Westney, M.D. Associate Professor Christopher G. Wood, M.D. Associate Professor

D epartment of P sychiatry Alan D. Valentine, M.D. Associate Professor

and Chair Ad Interim

Maher Karam-Hage, M.D. Assistant Professor Anis Rashid, M.D. Assistant Professor

Administration O ffice of the P resident John Mendelsohn, M.D. President Harry R. Gibbs, M.D. Vice President for Institutional Diversity Adrienne C. Lang Vice President for Center Programs Mark A. Moreno Vice President for Governmental Relations Patrick B. Mulvey Vice President for Development Stephen C. Stuyck Vice President for Public Affairs

O ffice of the E xecutive V ice P resident and P hysician - in - C hief Thomas W. Burke, M.D. Executive Vice President and Physician-in-Chief Gerard J. Colman Vice President and Chief of Clinical Operations Thomas W. Feeley, M.D. Vice President for Medical Operations Lewis E. Foxhall, M.D. Vice President for Health Policy Joel D. Lajeunesse Vice President and Head, Division of Pharmacy Sharon K. Martin Vice President for Process Improvement M.A. Rodriguez, M.D. Vice President for Medical Affairs Barbara L. Summers, Ph.D. Vice President and Chief Nursing Officer Frank R. Tortorella, J.D. Vice President for Clinical Support Services Michael S. Ewer, M.D. Special Assistant to the Vice President J. Taylor Wharton, M.D. Special Assistant to the President

O ffice of the executive V ice P resident and C hief A cademic O fficer Margaret L. Kripke, Ph.D. Executive Vice President and Chief Academic Officer Robert C. Bast Jr., M.D. Vice President for Translational Research Bernard Levin, M.D. Vice President and Head, Division of Cancer Prevention and Population Sciences Maurie Markman, M.D. Vice President for Clinical Research Stephen P. Tomasovic, Ph.D. Senior Vice President for Academic Affairs and Vice President for Extramural Programs Ad Interim Leonard A. Zwelling, M.D., M.B.A. Vice President for Research Administration

O ffice of the E xecutive V ice P resident Leon J. Leach Executive Vice President William A. Daigneau Vice President for Operations and Facilities Management Christopher C. Capelli, M.D. Vice President for Technology Transfer James P. Dorn Vice President for Human Resources R. Dwain Morris Vice President for Finance and Accounting John A. Tietjen Vice President for Patient Financial Services Lynn H. Vogel, Ph.D. Vice President and Chief Information Officer

O ffice of the S enior V ice P resident for B usiness D evelopment and R egulatory A ffairs R. Dan Fontaine, J.D. Senior Vice President for Business Development and Regulatory Affairs Carrie Lyons, J.D. Vice President and Chief Compliance Officer Matthew A. Masek, J.D. Vice President and Deputy Chief Legal Officer Hugh C. Wilfong II, J.D. President and Chief Executive Officer M. D. Anderson Services Corporation

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Basic Science Departments D epartment of B iochemistry and molecular biology William H. Klein, Ph.D.

Professor and Chair Michelle Barton, Ph.D. Associate Professor Andreas Bergmann, Ph.D. Associate Professor Richard Brennan, Ph.D. Professor Ping Bu, M.D., Ph.D. Instructor Xiaomin Chen, Ph.D. Assistant Professor Jang-Hyeon Cho, Ph.D. Instructor Sharon R. Dent, Ph.D. Professor Yasuhide Furuta, Ph.D. Associate Professor Kathleen M. Gajewski, Ph.D. Instructor Michael J. Galko, Ph.D. Assistant Professor Jayanthi Gudikote, Ph.D. Instructor Georg Halder, Ph.D. Associate Professor Raymond H. Jacobson, Ph.D. Assistant Professor Randy L. Johnson, Ph.D. Associate Professor Madhuri Kango-Singh, Ph.D. Instructor Takae Kiyama, Ph.D. Instructor Malgorzata Kloc-Stepkowska, Ph.D. Associate Professor Warren S. Liao, Ph.D. Associate Professor Todd M. Link, Ph.D. Assistant Professor James A. MacLean II, Ph.D. Instructor Chai-An Mao, Ph.D. Instructor Pierre D. McCrea, Ph.D. Professor Xiuqian Mu, M.D., Ph.D. Assistant Professor Riitta Maarit Nolo, Ph.D. Instructor Jan Parker-Thornburg, Ph.D. Assistant Professor Manjeet Kumar Rao, Ph.D. Assistant Professor Robert A. Schulz, Ph.D. Professor Maria Schumacher, Ph.D. Assistant Professor Shinako Takada, Ph.D. Assistant Professor Miles F. Wilkinson, Ph.D. Professor

D epartment of BIOMEDICAL ENGINEERING

D epartment of cancer genetics

Charles W. Patrick Jr., Ph.D.

Guillermina Lozano, Ph.D.

Associate Professor and Deputy Chair Ad Interim Michele Follen, M.D., Ph.D. Professor Anshu Bagga Mathur, Ph.D. Assistant Professor Kathryn Peek, Ph.D. Associate Professor Konstantin V. Sokolov, Ph.D. Assistant Professor

D epartment of C ancer biology Isaiah J. Fidler, D.V.M., Ph.D.

Professor and Chair

Krishnakumar Balasubramanian, Ph.D. Assistant Professor Menashe Bar Eli, Ph.D. Professor Douglas D. Boyd, Ph.D. Professor Dina Chelouche Lev, M.D. Assistant Professor Woonyoung Choi, Ph.D. Instructor Feng Chu, Ph.D. Instructor Dominic Fan, Ph.D. Associate Professor Gary E. Gallick, Ph.D. Professor Baoan Ji, M.D., Ph.D. Assistant Professor Sun Jin Kim, M.D., Ph.D. Assistant Professor Robert Langley, Ph.D. Assistant Professor Craig Logsdon, Ph.D. Professor Joseph McCarty, Ph.D. Assistant Professor David J. McConkey, Ph.D. Professor Vladislava Melnikova, Ph.D. Instructor Janet E. Price, Ph.D. Associate Professor Vijaya Ramachandran, Ph.D. Instructor Alan J. Schroit, Ph.D. Professor Justin M. Summy, Ph.D. Instructor Zhengxin Wang, Ph.D. Assistant Professor Chunhong Yan, Ph.D. Instructor Weihua Zhang, M.D., Ph.D. Instructor

Professor and Chair

Shamima Akhter, Ph.D. Instructor Linda L. Bachinski, Ph.D. Assistant Professor Sandy Chang, M.D., Ph.D. Assistant Professor Yibin Deng, Ph.D. Assistant Professor Vicki D. Huff, Ph.D. Associate Professor Mini Kapoor, Ph.D. Assistant Professor Ann M. Killary, Ph.D. Professor Ralf Krahe, Ph.D. Associate Professor Randy J. Legerski, Ph.D. Professor Ying Luo, Ph.D. Instructor Sadhan Majumder, Ph.D. Professor Angabin Matin, Ph.D. Assistant Professor Sudit S. Mukhopadhyay, Ph.D. Instructor Asha S. Multani, Ph.D. Assistant Professor Louise C. Strong, M.D. Professor Young-Ah Suh, Ph.D. Instructor Shunbin Xiong, Ph.D. Instructor Hao Zhang, Ph.D. Instructor Nianxiang Zhang, Ph.D. Instructor Xiaoshan Zhang, M.D., Ph.D. Instructor

D epartment of carcinogenesis John DiGiovanni, Ph.D.

Professor and Chair Gerald M. Adair, Ph.D. Associate Professor Claudio M. Aldaz, M.D. Professor Joe M. Angel, Ph.D. Assistant Professor Mark T. Bedford, Ph.D. Associate Professor Fernando Jose Benavides, D.V.M., Ph.D. Assistant Professor Thomas R. Berton, Ph.D. Instructor Andrew P. Butler, Ph.D. Associate Professor Dhyan Chandra, Ph.D. Instructor Donghang Cheng, Ph.D. Instructor Lezlee G. Coghlan, D.V.M. Associate Professor Claudio J. Conti, D.V.M., Ph.D. Professor

Susan M. Fischer, Ph.D. Professor Robin Fuchs-Young, Ph.D. Associate Professor Irma B. Gimenez-Conti, D.D.S., Ph.D. Associate Professor Rafael E. Herrera, Ph.D. Instructor Yinling Hu, Ph.D. Assistant Professor David G. Johnson, Ph.D. Professor Kaoru Kiguchi, M.D., Ph.D. Associate Professor Micheline Laurent, Ph.D. Instructor Michael C. MacLeod, Ph.D. Professor David L. Mitchell, Ph.D. Professor Rodney S. Nairn, Ph.D. Professor Okkyung Rho, Ph.D. Instructor Ellen R. Richie, Ph.D. Professor Joyce E. Rundhaug, Ph.D. Assistant Professor Virginia L. Scofield, Ph.D. Instructor Jianjun Shen, Ph.D. Associate Professor Xuetong Shen, Ph.D. Assistant Professor Dean G. Tang, Ph.D. Associate Professor Karen M. Vasquez, Ph.D. Associate Professor Cheryl L. Walker, Ph.D. Professor Paul K. Wong, Ph.D. Professor Mingshan Yan, M.D. Assistant Professor

F a c u l t y

D epartment of immunology Yong-Jun Liu, M.D., Ph.D.

Professor and Chair Honnavara N. Ananthaswamy, Ph.D. Professor Laura Bover, Ph.D. Instructor ad interim Wei Cao, Ph.D. Assistant Professor Chen Dong, Ph.D. Associate Professor Valeria Facchinetti, Ph.D. Instructor Michel Gilliet, M.D. Assistant Professor Margaret L. Kripke, Ph.D. Professor Natalia Martin-Orozco, Ph.D. Instructor Hector Martinez-Valdez, M.D., Ph.D. Associate Professor Bradley W. McIntyre, Ph.D. Professor Roza Nurieva, Ph.D. Instructor F. Qin, Ph.D. Assistant Professor Eulogia Roman, Ph.D. Instructor Jagannadha K. Sastry, Ph.D. Professor Kimberly Schluns, Ph.D. Assistant Professor Stephen E. Ullrich, Ph.D. Professor Kui Shin Voo, Ph.D. Instructor Yui-Hsi Wang, Ph.D. Instructor Stephanie S. Watowich, Ph.D. Associate Professor Tomasz Zal, Ph.D. Assistant Professor Chengming Zhu, Ph.D. Assistant Professor

D epartment of molecular and cellular oncology Mien-Chie Hung, Ph.D.

Professor and Chair

Seetharaman Balasenthil, Ph.D. Instructor Qing Qing Ding, Ph.D. Instructor Elsa Renee Flores, Ph.D. Assistant Professor Mickey Hu, Ph.D. Assistant Professor Jim Klostergaard, Ph.D. Professor Rakesh Kumar, Ph.D. Professor Mong-Hong Lee, Ph.D. Associate Professor Hui-Kuan Lin, Ph.D. Assistant Professor Xin Lin, Ph.D. Associate Professor

Dos Sarbassov, Ph.D. Assistant Professor Ming Tan, M.D., Ph.D. Assistant Professor Stephen P. Tomasovic, Ph.D. Professor Michael W. Van Dyke, Ph.D. Associate Professor Rui-An Wang, Ph.D. Assistant Professor Shao-Chun Wang, Ph.D. Assistant Professor Weiya Xia, M.D. Assistant Professor Vashisht Gopal Yennu Nanda, Ph.D. Instructor Hirohito Yamaguchi, Ph.D. Assistant Professor Yun You, M.D. Instructor Dihua Yu, M.D., Ph.D. Professor

D epartment of molecular genetics Benoit deCrombrugghe, M.D.

Professor and Chair Yuko Mori-Akiyama, Ph.D. Instructor Richard R. Behringer, Ph.D. Professor Nanyue Chen, M.D., Ph.D. Assistant Professor Chris Cretekos, Ph.D. Instructor Sankar N. Maity, Ph.D. Associate Professor William W. Mattox, Ph.D. Associate Professor Lalitha Nagarajan, Ph.D. Associate Professor Jill Schumacher, Ph.D. Associate Professor Michael J. Siciliano, Ph.D. Professor Krishna Sinha, Ph.D. Instructor Sonali Sonnylal, Ph.D. Instructor Chuan-Fen Wu, Ph.D. Instructor

D epartment of V eterinary M edicine and surgery Peggy T. Tinkey, D.V.M.

Associate Professor and Chair Agatha Borne, D.V.M., Ph.D. Associate Professor Suzanne Craig, D.V.M. Associate Professor Sherry Klumpp, D.V.M. Professor Katherine A. Naff, D.V.M. Assistant Professor L. Clifton Stephens, D.V.M., Ph.D. Professor Rajesh Uthamanthil, D.V.M., Ph.D. Assistant Professor Carolyn S. Van Pelt, D.V.M., Ph.D. Professor

D epartment of V eterinary sciences Christian Abee, D.V.M. Professor and Chair Kirstin F. Barnhart, D.V.M., Ph.D. Assistant Professor Wallace Baze, D.V.M., Ph.D. Professor Bruce J. Bernacky, D.V.M. Assistant Professor Stephanie J. Buchl, D.V.M. Assistant Professor Gary L. Johanning, Ph.D. Associate Professor Mark J. McArthur, D.V.M. Associate Professor Pramod N. Nehete, Ph.D. Associate Professor William C. Satterfield, D.V.M. Professor Steven J. Schapiro, Ph.D. Associate Professor Feng Wang-Johanning, M.D., Ph.D. Associate Professor Lawrence E. Williams, Ph.D. Associate Professor

External Advisory Board Members M. D. Andersonâ&#x20AC;&#x2122;s External Advisory Board is comprised of highly regarded scientific advisors who consult with M. D. Anderson faculty leaders on specific programmatic research initiatives. Martin D. Abeloff, M.D. Johns Hopkins University Carolyn R. Aldige Cancer Research and Prevention Foundation, Alexandria, Va. Ken-ichi Arai, M.D., Ph.D. The Tokyo Metropolitan Institute of Medical Science James O. Armitage, M.D. University of Nebraska Richard Caprioli, Ph.D. Vanderbilt University Susan J. Curry, Ph.D. University of Illinois at Chicago Andrew Dannenberg, M.D. New York Presbyterian Hospital-Cornell Sir Ara Darzi, M.D. Imperial College London Sarah Donaldson, M.D. Stanford University Cancer Center Norman R. Drinkwater, Ph.D. University of Wisconsin-Madison Zvi Y. Fuks, M.D. Memorial Sloan-Kettering Cancer Center Steven N. Goodman, M.D. Johns Hopkins University H. Robert Horvitz, Ph.D. Howard Hughes Medical Institute Richard D. Kolodner, Ph.D. University of California, San Diego

Provided by Faculty Academic Affairs, the faculty list reflects individuals with full-time faculty appointments. List as of January 2007.

Joan Massague, Ph.D. Memorial Sloan-Kettering Cancer Center Harold Moses, M.D. Vanderbilt-Ingram Cancer Center Richard J. Oâ&#x20AC;&#x2122;Reilly, M.D. Memorial Sloan-Kettering Cancer Center Edward Sausville, M.D., Ph.D. University of Maryland Greenebaum Cancer Center Richard Schilsky, M.D. University of Chicago Thomas A. Sellers, Ph.D. H. Lee Moffitt Cancer Center and Research Institute David Sidransky, M.D. Johns Hopkins University Ellen Sigal, Ph.D. Friends of Cancer Research, Arlington,Va. Cox P. Terhorst, Ph.D. Beth Israel Deaconess Medical Center Craig B. Thompson, M.D. Abramson Family Cancer Research Institute, University of Pennsylvania Health System Jeffrey M. Trent, Ph.D. Translational Genomics Research Institute, Phoenix, Az. Richard L. Wahl, M.D. Johns Hopkins University

The University Cancer Foundation Board of Visitors 2006 - 2007 Members

Marc J. Shapiro Chair

Ernest H. Cockrell Chair-Elect

Life Members

Mrs. Glenda R. Kane

Mr. Thomas D. Anderson

Mr. Melvyn N. Klein

Mrs. Barbara Bush

Mr. R. Bruce LaBoon

The Hon. George H. W. Bush

Mrs. Marty V. Leonard

Mr. Edwin L. Cox

Mr. Max Levit

Mr. Paul R. Haas

Mr. Michael R. Levy

Dr. Charles A. LeMaistre

Mr. Harry J. Longwell

Mrs. Julia Jones Matthews

Mrs. Mary Anne McCloud

Mr. W. A. “Tex” Moncrief, Jr.

Mr. Red McCombs

The Hon. Robert Mosbacher

Mr. Michael D. McKinnon Mr. Randall Meyer

Senior Members

Nancy B. Loeffler Vice Chair

Peter R. Coneway Past Chair

E x e c u t i v e C o mm i t t e e

C h a i r m a n ’ s C o mm i t t e e

Mr. Marc J. Shapiro

Chair

Mr. Ernest H. Cockrell Mrs. Nancy B. Loeffler Mrs. Judy Ley Allen Mr. Philip J. Burguières Mr. Ben A. Guill Mr. Melvyn N. Klein Mr. Harry J. Longwell Mr. Steven L. Miller Mr. Gerald B. Smith Mr. Charles W. Tate

Chair

Mr. Ben A. Guill Audit

Mr. Alan D. Feld Bylaws

The Hon. John S. Anderson

Mr. B. M. Rankin, Jr.

Mr. Edward Azar

Ms. Regina J. Rogers

The Hon. James A. Baker III

Mrs. Peggy Sewell

The Hon. Dolph Briscoe, Jr.

Mr. Joseph F. Shaughnessy

Mr. Roy A. Butler

Mr. Charles M. Simmons

Mr. Charles Butt

Dr. Richard E. Wainerdi

Mr. William E. Carl

Mr. W. Temple Webber, Jr.

Mr. James D. Dannenbaum

Mrs. Isabel B. Wilson

Mr. Leon Davis Mr. John H. Duncan, Sr.

Mr. Rodney H. Margolis / Mr. W. Robert Nichols III

Mr. Gibson Gayle Jr.

Mrs. Joan Schnitzer Levy / Mrs. Beth Sanders Moore

Mr. Gary F. Gibson

Mr. Wayne Gibbens / Mr. Ned S. Holmes / Mrs. Glenda R. Kane

Miss Lyda Hill

Mr. Ernest H. Cockrell

Mr. Joseph D. Jamail

Mrs. Nancy B. Loeffler

Mr. Lenoir M. Josey II

Events

Government Relations Institutional Initiatives Membership and Board Development

Mrs. Kay M. Onstead

Mr. Dillon J. Ferguson

Development

Mr. W. Robert Nichols III

Mr. John D. Alexander, Jr.

Ms. Regina J. Rogers / Mr. Steven H. Wasserman Community Relations

Mr. Steven L. Miller

Mr. George E. Foreman

Mr. Wayne Gibbens

Ms. Frances Ginsburg

Mr. Forrest E. Hoglund The Hon. Roy M. Huffington

Mr. James F. Justiss, Jr.

M e m b e r s - at -L a r g e Mr. Stanford J. Alexander Mr. Moshe Azoulay Mrs. Sally B. Berry Mrs. Susan Bischoff Mrs. Ann Cox Bomer Pastor Kirbyjon H. Caldwell Mrs. Jane M. Cizik Mr. Gus H. Comiskey Jr. Mr. Rufus P. Cormier Mr. Randy Engstrom Mr. Stephen L. Feinberg

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Mr. George A. Finley III

Mr. B. Daryl Bristow

Mrs. Stacie McDavid

Mrs. Phyllis S. Hojel

Mr. Joseph M. Grant

Mr. Joel Brochstein

The Hon. Thomas F. McLarty III

Mr. Ned S. Holmes

Mr. F. O’Neil Griffin

Mr. Kyle C. Brooks

Mr. C. John Miller

Mr. Woody L. Hunt

Mr. D. Alter Holand

Mr. Philip J. Burguières

Mr. James J. Mulva

Mr. Charles E. Hurwitz

Mrs. Barbara Hurwitz

Mr. Ernest H. Cockrell

Mr. David G. Nance

Dr. Mae C. Jemison

Dr. Henry A. Kissinger

Mrs. Anne P. Connally

Mr. Paul F. Oreffice

Mrs. Neda Ladjevardian

Mrs. Nancy B. Loeffler

Mr. Phil D. Conway

Mr. Patrick Oxford

Mr. Eric Lane

Mr. Jeff B. Love

Mrs. Shirley M. Coskey

The Hon. Jeanne L. Phillips

Mr. C. Berdon Lawrence

Mrs. Margaret Love

Mrs. Myrna Deckert

Mr. Jack P. Randall

Mrs. Marlene A. Malek

Mr. Kade L. Matthews

Mr. Ben A. Donnell

Mr. William E. Rosenthal

Mr. Jack L. Martin

Mr. L. Lowry Mays

Mr. William J. Doré, Sr.

Mrs. Helen Lho Ryu

Mr. E. Scott Mead

Ms. Sonceria Messiah-Jiles

Mr. S. Stacy Eastland

Mr. Marc J. Shapiro

Mr. Allen A. Meyer

Mrs. Kit T. Moncrief

Mr. Alan D. Feld

Mr. Matthew R. Simmons

Mr. Richard W. Mithoff

Mr. Henry G. Musselman

Mr. Jerry E. Finger

Mr. H. Leighton Steward

Mr. William A. Monteleone

Mr. Dennis E. Nixon

Mr. John F. Fort III

Mr. Charles W. Tate

Mrs. Beth Sanders Moore

Mr. C. Lamar Norsworthy III

Mr. Steve L. Fox

Mr. J. Virgil Waggoner

Mr. Lewis J. Moorman III

Mrs. Jan R. Pickens

Jack M. Gill, Ph.D.

Mrs. Marie F. Wise

Mrs. Pamela K. Onstead

Mr. Federico Sada

Mr. David M. Grimes II

Mr. Melvyn L. Wolff

Mrs. Nelda C. Pickens

Mrs. Nancy M. Seliger

Mr. Arden R. Grover

Mr. Robert I. Small

Mr. Ben A. Guill

Mr. Gerald B. Smith

Mr. L. David Hanower

Mr. J. Michael Solar

Mrs. Gloria Hicks

Mrs. Janice Thomas Vinson

Mr. Yerger Hill III

The Hon. Stephen A. Wakefield

Mr. Jeffrey C. Hines

Mr. Steven H. Wasserman

Mrs. Desiree Lyon Howe

Mrs. Margaret Alkek Williams

Mrs. Sydney Huffines Mr. Gary G. Jacobs

Members Mr. Richard C. Adkerson Mrs. Judy Ley Allen Mr. Robert J. Allison, Jr. Mr. Paul F. Barnhart, Jr. Mr. Michael G. Bartolotta Mr. Jack S. Blanton, Sr. Mr. John Baxter Brinkmann

Mrs. Judith Jaynes Mr. George F. Kettle Mrs. Nancy G. Kinder Mr. David H. Koch Mr. Gregory A. Kozmetsky Mrs. Elyse Lanier Mrs. Mary V. Lester Mrs. Joan Schnitzer Levy Mr. Rodney H. Margolis

Mr. Ali A. Saberioon A s s o c i at e M e m b e r s The Hon. Linda L. Addison The Honorable George L. Argyros Mr. Lawrence E. Bathgate II Mr. Giorgio Borlenghi Grace L. Butler, Ph.D. Mr. Clarence P. Cazalot Jr. Mr. John B. Connally III Mrs. Charline Dauphin

Mr. Andrew E. Sabin The Hon. Alan K. Simpson Mr. Stephen D. Susman Mr. McHenry T. Tichenor, Jr. Mr. Robert B. Tudor III Mrs. Cheryl Lockton Williams Mrs. Randa Duncan Williams Mr. Steven M. Zager The Hon. Joseph H. Zappala

Mrs. Linnet F. Deily Mrs. Lorraine Dell Mr. G. Steven Farris Mrs. Patsy S. Fourticq Mr. Michael E. Frazier Mr. Terry M. Giles Mr. Thomas S. Glanville

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Partners in Making Cancer History The University of Texas M. D. Anderson Cancer Center gratefully acknowledges the following individuals, foundations, corporations and others who made a commitment of at least $1,000 between September 1, 2005, and August 31, 2006.

2SVRR, LLC 3D Communications A & A Cattle Company A & M Investments Mr. and Mrs. Myles Aaronson Abbott Fund Abbott Molecular Inc. Dr. and Mrs. Christian R. Abee Mr. Carlos Abello John and Virginia Abercrombie Mr. and Mrs. J. Michael Ables Mr. Peter Aboytes Abraham Trading Company Accelerate Brain Cancer Cure, Inc. (ABC2) ACG Houston Mr. and Mrs. Anthony L. Ach Ms. Sharan Acker Red & Robyn Adair Memorial Charity Dinner Mr. and Mrs. Charles L. Adams Mr. and Mrs. Craig S. Adams Elbert L. and Erin S. Adams Ms. Johnnie D. Adams Mr. and Mrs. K. S. Adams, Jr. Mr. and Mrs. Robert S. Adams Mr. and Mrs. Roy B. Adams Estate of N. Arthur Adamson Mr. Terence E. Adderley Mr. Larry C. Addington Mr. and Mrs. Gerhard P. Adenacker Ms. Sandra J. Adkisson Administaff, Inc. Adorno & Yoss Advanced Micro Devices (AMD) AGA Foundation for Digestive Health and Nutrition Mr. Bahman Ahmadian Mr. and Mrs. Roger E. Ailes Dr. and Mrs. Joseph T. Ainsworth Akin, Gump, Strauss, Hauer & Feld, L.L.P.

Mr. Gerald M. Akins Al Bunetta Management, Inc. Alamo Ovarian Cancer Alliance Mr. and Mrs. Bruce J. Albe Albemarle Corporation Mr. David R. Albin Alborg, Veiluva & Epstein LLP Mrs. William D. Albrecht Mr. and Mrs. John D. Alexander, Jr. Mr. Leslie L. Alexander Stanford and Joan Alexander Mr. and Mrs. Rex E. Alford John R. and Susan Landon Alford Foundation Mr. Ahmad Alguneh and Ms. Ateiah Alvandi Albert and Margaret Alkek Foundation Allamon Tool Company, Inc. M. Diane and Joe M. Allbaugh Mr. Joe L. Allbritton The Allbritton Foundation Mr. and Mrs. Conrad K. Allen Mr. and Mrs. Marion T. Allen Mr. and Mrs. Robert H. Allen Rita Allen Foundation Allergan Alliance for Cancer Gene Therapy Ms. Nancy C. Alliegro Mr. and Mrs. Pierce M. Allman Mr. John R. Allred Aloka Mr. and Mrs. Juan F. Alonso Alpha Kappa Delta Phi Alpha Shirt Company Alpharma Alta Vista Church Altana Pharma AG Altor Bioscience Corporation and Dr. Patrick Hwu Maurice Amado Foundation Dr. Paula Amaon and Mr. Gary P. Amaon

Endowed Distinguished University Chairs* Harry Carothers Wiess Distinguished University Chair for Cancer Research Robert C. Bast Jr., M.D. The Robert A. Welch Distinguished University Chair in Chemistry Richard G. Brennan, Ph.D. Frederick F. Becker Distinguished University Chair for Cancer Research Stanley R. Hamilton, M.D. Samsung Distinguished University Chair in Cancer Medicine Waun Ki Hong, M.D. Olga Keith Wiess Distinguished University Chair for Cancer Research Margaret R. Spitz, M.D.

*As of January 2007

Ambion, Inc. American Acadamy of Dermatology American Alloy Steel, Inc. and A. J. Moore American Association for Cancer Research American Brain Tumor Association American College of Surgeons American Diabetes Association The American Gastroenterological Association American Geriatrics Society American Hospice, Inc. American International Group, Inc. American Petroleum Institute American Pharmaceutical Partners, Inc. American Society for Therapeutic Radiology & Oncology American Society of Clinical Oncology American Urological Association AmerisourceBergen Services Corporation Amgen Foundation Amgen, Inc. The Homer Ammann Trust AMN Television Marketing Amschwand Sarcoma Cancer Foundation Anadarko Petroleum Corporation Mr. and Mrs. Charles A. Anderson Mr. Charles B. Anderson Mr. and Mrs. Jack R. Anderson Mr. and Mrs. John H. Anderson, Jr. Honorable and Mrs. John S. Anderson Ken and Mary Anderson Mrs. Marjorie M. Anderson Mr. and Mrs. Richard T. Anderson Mr. Robert R. Anderson Mr. Robert W. Anderson Mr. and Mrs. Sydney J. Anderson Mr. and Mrs. Thomas D. Anderson Carl C. Anderson, Sr. and Marie Jo Anderson Charitable Foundation M. D. Anderson Foundation Robert F. & Marjorie Anderson Family Foundation Mr. and Mrs. Robert D. Anding Mr. and Mrs. Thurmon M. Andress Andrew Stack Enterprises, LLC Mr. and Mrs. Barry G. Andrews In Memory of Elfriede R. Andrews Mr. and Mrs. Glynn Andrews Mr. and Mrs. Paul E. Andrews The Andrews Foundation Andrews Kurth LLP Anglo-Suisse Offshore Partners, LLC Animal Care Systems, Inc. Anonymous An Anonymous Fund of The Dallas Foundation The Honorable and Mrs. Hushang Ansary Answer to Cancer Foundation Mr. and Mrs. Ronald E. Antes

Mrs. Kirsten Anthony Antigenics Inc. Dr. Takashi Anzai Apache Corporation Aplastic Anemia & MDS International Foundation, Inc. Applera Corporation Applied Materials Dr. and Mrs. Van M. Ardoin Ark Cans, Inc. Mrs. Tobin Armstrong Mr. and Mrs. Stephan Arndt Estate of William B. Arndt, Jr. Ms. Terri L. Arnett Mr. and Mrs. William Thomas Arnold II Mr. William G. Arnot, Jr. Mr. Ernest C. Arrington Arrow International, Inc. Ms. Yvonne Arthur Ascent Energy Mr. H. G. Ash ASML Inc. Aspen Community Foundation Mr. and Mrs. James Z. Assef Mr. and Mrs. Terence N. Assink Astellas Pharma US, Inc. AstraZeneca LP AstraZeneca UK Astros in Action Foundation AT&T Foundation Mrs. Lara G. Atchison Mrs. Nancy E. Atha Ms. Bessie M. Atkins Dr. Holly G. Atkinson ATL Canadian Technologies Ltd. Atlanta United Fund Atos Medical, Inc. Nancy and Kirby Attwell Mr. Richard C. Auchterlonie Dr. and Mrs. Arthur I. Auer Isaac and Carol Auerbach Family Foundation Mr. and Mrs. Earl C. Austin Mr. and Mrs. H. Brent Austin Austin Community Foundation Austin Vintage Guitars Austin White Lime Co. Avaya Aventis Pharmaceuticals, Inc. Mr. Andrew Avillo and Mrs. Maria Arwitz Avon Foundation Mr. and Mrs. Robert R. Awe Axis Healthcare Communications LLC AXXORA, LLC The Ayco Charitable Foundation Ms. Donna M. Ayers Mr. and Mrs. R. C. Ayers, Jr. Mr. and Mrs. Edward Azar B. Braun Medical Inc. Mr. and Mrs. Edward Backhaus Mr. and Mrs. Michael Bacon The Doug Bacon Family

Mr. and Mrs. Peter W. Badger Mr. and Mrs. Philip A. Bahr Mr. and Mrs. Randy Bailey Bailey Banks & Biddle Mr. Thomas B. Baird Estate of Verna M. Baird Mr. and Mrs. Richard O. Baish Ms. Carol H. Baker and Mr. William H. Tyler Ms. Cathy L. Baker and Mr. Andrew N. Pedder Mrs. Elizabeth H. Baker The Honorable and Mrs. James A. Baker III Mr. and Mrs. John C. Baker Mr. Lewis T. Baker, Jr. Marie R. Baker Baker Hughes Foundation Mr. and Mrs. George A. Baldwin, Jr. Mr. and Mrs. Robert C. Balfour III Balfour Foundation, Inc. Mr. and Mrs. Franklin B. Balke Mr. John G. Ball Mr. and Mrs. Claude M. Ballard Mr. and Mrs. Robert S. Bambace Bandera Drilling Co., Inc. Captain and Mrs. Charlie Bangert Bank of America Bank of America Foundation The Honorable and Mrs. H. Douglas Barclay Bard Access Systems, Inc. Barfield Family Private Foundation Mr. C. L. Barlow Mr. Bob R. Barnard Mrs. Ann Barnes Mrs. Geraldine V. Barnes Mr. and Mrs. Michael Barnes Mr. Arnold R. Barnett J. H. Baroco Foundation Inc. Dr. and Mrs. F. T. Barr The Kenneth J. and Cora Barr Foundation Dr. and Mrs. Ermilo Barrera, Jr. Mr. and Mrs. James N. Barrett Mr. Joseph P. Barrett Michael and Cindy Barrett Mr. and Mrs. Charles Barrier Barriere Construction Co., L.L.C. Mr. and Mrs. Ed Barron Mr. and Mrs. James A. Bartlett Mrs. Iva Lea Barton The Brady Barton Foundation Mr. and Mrs. Sid R. Bass Ms. Anne S. Batchelder Mr. and Mrs. Bradley R. Bates Mr. and Mrs. Larry C. Bates Mr. Steven Bates Ms. Mara Michelle Batlin and Mr. David B. Deniger Mr. and Mrs. John D. Baudoin Ruth and Ted Bauer Family Foundation Mrs. Helen F. Baughman

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Baxa Corporation Bayer Corporation Pharmaceutical Division Bayer HealthCare Estate of Margaret L. Bayhi Baytown Business and Professional Women Mr. and Mrs. J. R. Bazzy BCM & Associates, Inc. Mr. and Mrs. Harold Beaird Mr. and Mrs. Pat C. Beaird Mr. and Mrs. Carlton E. Beal, Jr. Mr. and Mrs. Kelly S. Beal Nancy and Barry Beal Mr. and Mrs. Spencer Beal Mr. and Mrs. Stuart Beal Ms. Cathryn Beamon The Theodore and Beulah Beasley Foundation, Inc. Beasley, Allen, Crow, Methvin, Portis & Miles, P.C. Mr. Wayne Beason Toni and Jeffery Beauchamp Beaumont Iron and Metal Corporation Bechtel Foundation Mr. and Mrs. David J. Beck Mr. Paul Beck Beck Bros., Inc. Beck, Redden & Secrest, L.L.P. Mr. Thomas Becker Beckman Coulter, Inc. Mr. and Mrs. Daniel E. Becnel, Jr. Becton Dickinson and Company Mr. and Mrs. William W. Bedford Mr. and Mrs. Louis A. Beecherl, Jr. Mr. and Mrs. Louis A. Beecherl III Mr. David C. Beeman Beeman Strong & Co., Inc. JoAnna and Robert Behl Mr. and Mrs. Christopher P. Belden Dr. and Mrs. Byrnes Belk Mr. and Mrs. Craig J. Bellamy Beloco Foundation, Inc. Mrs. Sophia Bender Dr. and Mrs. Robert S. Benjamin Mr. and Mrs. Edward C. Benninger Mr. and Mrs. Brent Alan Benoit Mrs. B. A. Bentsen Mr. Donald L. Bentsen, Sr. Mr. and Mrs. Lan Bentsen Bergen County United Way Berger Cattle Company Ltd. Berlex Laboratories Mrs. Cynthia J. Berning The Honorable and Mrs. Stuart A. Bernstein Mr. and Mrs. Frank R. Berry Mr. and Mrs. Lyndel G. Berry Mr. and Mrs. William Baine Berry The Eugenia and Lawrence A. Bertetti Foundation Bethyl Laboratories, Inc. Mr. and Mrs. Harry M. Bettis, Jr. Bettis, Boyle & Stovall, Inc. Mr. David C. Betz Beusa Energy, Inc. The Beverage Institute for Health & Wellness Mrs. Billie E. Beyer Mr. Richard H. Bickerstaff Ms. Susan L. Bickley

Mr. William M. Biddison Margaret T. Biddle Foundation Mrs. MaryAnn Bieber Mrs. Sarah W. Biedenharn Mrs. Diane M. Bigelow Bill Jackson, Inc. Mr. and Mrs. Thomas J. Billings Billington Imports, Inc. Mr. and Mrs. Michael W. Bingham Bioenvision, Inc. Biogen Idec Biomedical Research Foundation Biomet, Inc. Biosphere Medical, Inc. The Bireley Family Foundation and Frank and Betty Bireley Mr. and Mrs. William M. Birk Mr. and Mrs. Gene H. Bishop Mr. and Mrs. Howard C. Bissell Mr. Robert O. F. Bixby BJ’s Restaurant & Brewery B-K Medical Systems, Inc. BKD, LLP Ms. Amelia Anne Black Dr. Karen S. Black Mr. and Mrs. Robert M. Black III Black Foundation Mr. and Mrs. Richard M. Blades Estate of Lucy Jane Blair Blair Corporation Mr. and Mrs. William D. Blake Mr. and Mrs. Jack S. Blanton, Sr. Mr. and Mrs. Kenneth E. Blaschke Mr. and Mrs. H. Paul Blezinger Mr. and Mrs. Steven R. Block David Block Foundation Mr. John W. Blome Mr. and Mrs. Mike Bloom Blue Bell Creameries, Inc. Blue Cross and Blue Shield of Texas Dr. and Mrs. A. Elmer Blum Mr. and Mrs. Melvyn H. Blum Boatner Family Foundation Mr. and Mrs. James R. Bobo Estate of Patricia D. Bohan Ms. Gretchen K. Bohnert Mr. and Mrs. Lucien E. Bolduc, Jr. Mr. and Mrs. William R. Boles, Sr. Mrs. Betsy C. Bolin Mr. Roscoe A. Bolton Ann and Jeff Bomer Edith F. Bondi Foundation Mr. and Mrs. Mike Bonini Mr. Doug Bonner Mary and Nicholas Bonrepos Mr. and Mrs. James A. Boone Mr. David Boothe Mr. and Mrs. Morris Boothe Boots & Coots Services, Inc. Mr. and Mrs. Giorgio Borlenghi Mr. and Mrs. Christopher M. Born The Borrello Charitable Fund of The Dallas Foundation Mr. and Mrs. James L. Bosler Boston Biochem, Inc. Boston Scientific Corporation Mr. and Mrs. Robert D. Botsford Mr. and Mrs. Winston F. Bott, Jr. Mr. and Mrs. Paul J. Bouchard Mr. and Mrs. Heyward H. Bouknight III Mr. J. Craig Bourgeois

Mr. and Mrs. Douglas J. Bourne Mr. and Mrs. J. Murry Bowden Ruth McLean Bowman Bowers Foundation The Bowes Family Foundation Mr. and Mrs. Donald E. Bowles, Jr. Mr. and Mrs. Robert L. Bowling III Boy Scouts of America, Troop 55 Mrs. Patricia K. Boyd Mr. and Mrs. Stephen L. Boyd Susan and Bob Boykin Dr. and Mrs. L. Eamonn Boyle BP Foundation, Inc. Mr. and Mrs. Bryan E. Bracewell Ms. Billye B. Bradley Mr. and Mrs. Francis R. Bradley Mr. and Mrs. Jeff S. Bradley Mr. and Mrs. Paul Bradshaw Mr. and Mrs. Sam K. Bradshaw Luther W. Brady, M.D. Mr. Raymond M. Brady Brandes Brothers Constructors, Inc. Mr. and Mrs. Paul R. Brandt Bratton Family Foundation Major General Leslie W. Bray, Jr. Ret. Brazos Capital Management Breast Cancer Research Foundation Mrs. Octavia D. Bredin Mr. Erich E. Bredl Mr. and Mrs. Daniel L. Breeding Mrs. Patricia Breen Mrs. Anne R. Brennan Mr. and Ms. Maurice Bresenhan Mr. Leonard W. Brickman Mr. and Mrs. John W. Bridger Bridgeway Capital Management, Inc. Bridgeway Charitable Foundation Mr. Richard W. Brietzke Mr. and Mrs. Robert F. Briggs The Ronnie and Gwen Briggs Foundation Briggs Freeman Real Estate Brokerage, Inc. Bennie Brigham Mr. and Mrs. Louis R. Brill Mr. and Mrs. Carl O. Brininstool Ms. Jan Wallace Briscoe and Mr. Stuart A. Briscoe III Bristol-Myers Squibb Company Mr. and Mrs. B. Daryl Bristow Bristow Group Inc. Mr. Tim Brittan Mr. and Mrs. Robert G. Brittingham Dr. and Mrs. James A. Broaddus Ms. Sherry M. Broadhead Broadhurst Foundation Mr. and Mrs. Joel Brochstein Raymond and Susan Brochstein Brookline Development Co., Inc. Mr. Chesley N. Brooks, Jr. Mr. and Mrs. Raymond J. Brooks Mr. and Mrs. Thomas J. Brorby Charles and Judith Broudy Mr. and Mrs. Scott N. Broudy Ms. Anne M. Broussard Joe Broussard II Mr. H. L. Brown, Jr. Mrs. Isabell L. Brown Mr. and Mrs. James D. Brown Mrs. Lillian W. Brown Mr. and Mrs. Peter N. Brown

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Game, Set, Match Linda and Jim McIngvale, owners of the Westside Tennis Club in Houston, raised more than $140,000 for M. D. Anderson during events surrounding the 2006 U.S. Men’s Clay Court Championships. Part of the gift came from tennis pro James Blake (left), who lost his father to stomach cancer. Blake donated $25,000 to gastric cancer research, which is under the direction of M. D. Anderson’s Lee M. Ellis, M.D. (right). In the midst of the U.S. Tennis Association activities, M. D. Anderson’s operating room nursing tennis team of Brian Jahrsdoerfer, Michel Lavoie, Peter Okpokpo and Warner Tse broke the Guinness World Record in doubles, playing for 48 hours, 15 minutes. They raised about $15,000 for the Children’s Cancer Hospital at M. D. Anderson. Mr. Philip L. Brown Mr. and Mrs. Robert L. Brown Mr. Willard B. Brown Mr. and Mrs. William C. Brown The Brown Foundation, Inc. Mrs. Nancy T. Broyles Ms. Laura S. Bruce Mrs. Ronica J. Bruce The Samuel B. and Lorena J. Bruce Charitable Trust Mr. and Mrs. D. Forrest Brumbaugh Mr. and Mrs. I. Jon Brumley Mr. and Mrs. W. M. Brumley, Jr. The Brunetti Foundation Donald R. Brunstrum Foundation Mr. Gary E. Brust Mrs. Carole Lou Bruton Mr. Ralph C. Bruton Estate of Tomye Bruzga Estate of Margaret Bryant Mr. and Mrs. Michael C. Brzozowski Mr. and Mrs. Darryl J. Bubar, Sr. Mr. and Mrs. Jack B. Buckley Mr. and Mrs. W. P. Buckthal Mr. and Mrs. Charles M. Buenger Mr. and Mrs. William T. Buida Bulgari Retail USA Bulldog Specialties Ltd. Mr. and Mrs. McCauley O. Bullock, Jr. Ms. Susan J. Bunnell Dr. and Mrs. William E. Burchill Dan and Penny Burck Mr. and Mrs. Thomas V. Burford Mr. and Mrs. Kenneth M. Burke, Sr. Mr. and Mrs. Doyle Burkett Bob and Beverly Burleson Burlington Resources

Mrs. Susan E. Burns Toni and Mark Burns Burroughs Wellcome Fund Mr. and Mrs. Collins Burton The Honorable and Mrs. George H. W. Bush Mr. Steven S. Bush Mr. and Mrs. Rob Bushman Mr. and Mrs. John B. Butler Charles Butt Estate of Albert E. Buzek Ms. Ellyn Bye Cabot Oil and Gas Corporation Ms. Elizabeth J. Cabraser Cactus Builders Kathleen C. Cailloux Family Foundation The Effie and Wofford Cain Foundation Mr. Joseph W. Calcaterra Mr. and Mrs. Lee Caldwell Mr. and Mrs. Michael J. Callaghan Mrs. Teri L. Wenglein-Callender and Dr. David L. Callender Mr. and Mrs. Dean L. Callender Mr. and Mrs. Don Callender Mr. and Mrs. Edward L. Callender Mr. and Mrs. Billy F. Calley Ms. Philippa Calnan Mr. and Mrs. Allastair Campbell Dr. Bruce Campbell and Mrs. Kathi Campbell Mr. and Mrs. T. C. Campbell Cancer Fighters of Houston, Inc. The Cancer League, Inc. Cancer Research & Treatment Fund Inc. Cancer Research and Prevention Foundation Cancer Research Institute

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Run for the Rose The Run for the Rose family fun run/walk and Ridin’ for the Rose motorcycle rally honored the memory, spirit and courage of Marnie Rose, M.D., who died from complications due to brain cancer in 2002. The Dr. Marnie Rose Foundation shares proceeds of the event with M. D. Anderson, which received approximately $100,000 for brain tumor research, and Memorial Hermann Children’s Hospital, where Rose was a first-year pediatric medical resident when she was diagnosed at age 27. Cancer Therapy and Research Center Cancer Treatment Research Foundation Mr. and Mrs. Joseph C. Canizaro Mr. and Mrs. Gardner W. Cannon Ms. Kristen Cannon Mr. Rudolph D. Cannon Mr. and Mrs. James J. Cano Mr. Eric D. Cantor Mr. James W. Cantor Carlos H. Cantu Family Foundation Mr. Paul E. Canzian CapRock Services Corp. Mr. and Mrs. G. Carbonel The Carcinoid Cancer Foundation, Inc. Cardinal Health Nuclear Pharmacy Services Cardinal Health, Inc. Mr. Frank V. Cardone Dr. and Mrs. Wallace H. Cardwell Mr. and Mrs. Terry L. Carius Mrs. Emory T. Carl Carlisle & Company Mr. and Mrs. Jack D. Carlson Ms. JoAnne R. Carlson Carlton Fields, P.A. Carmel Pharma, Inc. Mr. and Mrs. David M. Carmichael Estate of Nancy D. Carmichael Mr. and Mrs. Brian J. Carmines David M. Carmines Memorial Foundation, Inc. Mr. and Mrs. William A. Carpenter, Jr. Carpenter Contractors of America, Inc. The Carrig Family Mr. and Mrs. Glen C. Carson Mr. W. Michael Carter Amon G. Carter Foundation The Scott Carter Foundation Mr. and Mrs. Gary Cartright Wendy Will Case Cancer Fund, Inc. Mr. and Mrs. Bob Casey III Mr. and Mrs. John W. Casey Mr. and Mrs. Frank J. Cassata

Dr. and Mrs. S. Ward Casscells III Castex Energy, Inc. Mr. and Mrs. James M. Caswell, Jr. Mr. and Mrs. Robert B. Caswell Catalyst Exhibits Mr. and Mrs. Earl D. Catlett Mrs. Jill H. Cauble Mr. and Mrs. Robert M. Cave Mr. and Mrs. Jack E. Caveney Mr. and Mrs. Robert L. Cavnar The Cayuga Foundation Mr. and Mrs. Clarence P. Cazalot, Jr. Cecily and Bob Harris Celebrate Life Golf Tournament Celgene Corporation Estate of Joe Celli Central Boat Rentals, Inc. Central Texas Barricades Inc. Centralized Payment Services Cephalon, Inc. Mr. John L. Cerny Mrs. Mary E. Certain Ms. Maxine Chalker-Mollick The Carole and Gene Chambers Foundation Chambers Medical Foundation The Chaney Family Foundation Dr. and Mrs. Jack H. Chang Mr. and Mrs. Brad Chapin The Chaplaincy Fund, Inc. Mr. and Mrs. John O. Chapman Mr. and Mrs. Robin P. Chapman Mr. and Mrs. Roy T. Chapman Mr. and Mrs. O. Don Chapoton Mrs. Carol S. Charles Mr. and Mrs. Donald Chase Chatham Hill Foundation Dr. Joseph J. Chen Cheniere Energy, Inc. Mr. and Mrs. Charles Dan Chenoweth Chesapeake Energy Corporation Mr. and Mrs. S. D. Chesebro’ Mr. and Mrs. James A. Chesebrough, Jr.

Employees of Chevron Chevron Corporation Chevron Phillips Chemical Co. LP ChevronTexaco Products Company Dr. Lois Chiasson-Stansbury Estate of Leona C. Chicoine Childhood Brain Tumor Foundation Children’s Leukemia Research Association, Inc. William C. & Antoinette M. Childs Foundation Lois Chiles and Richard Gilder The Chiang Ching-Kuo Foundation for International Scholarly Exchange (USA) Mrs. Carolyn Chipman Mr. and Mrs. Brad Chisick Mr. and Mrs. Sherman S. Chiu Mr. Phillip Babe Choate ChondroGene Choose Hope, Inc. David A. and Mary Jo Christensen Mr. and Mrs. Gary R. Christopher Mr. and Mrs. Ching-Wu Chu CIG Media Group, L.P. Mr. and Mrs. Arthur Ciocca Ciphergen CITGO Petroleum Corporation Citizens First Bank City of Houston, Texas CIVCO/MEDTEC Robert and Jane Cizik Foundation Clarient Diagnostic Services Mr. Richard Clark Mrs. Virginia Clark The Honorable and Mrs. William P. Clements, Jr. Clements Real Estate #2 Dr. and Mrs. John B. Clemmons Mr. and Mrs. J. M. Clepper The Cleveland Foundation Mr. Harold Clevenger Mr. and Mrs. James F. Clingman, Jr.

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Clinton Central School District CLL Global Research Foundation Mr. David Clough ClubCorp, Inc. Clutch City Foundation CMC Construction Services CMC Sterling Steel CMC Texas Cold Finished Steel Inc. CNA Insurance Companies Coastal Spray Company Cobblestone Construction Inc. The Coca-Cola Foundation Mr. and Mrs. Allen H. Cocanougher Mr. and Mrs. Ernest H. Cockrell The Cockrell Family Fund The Cockrell Foundation Cockrell Interests, Inc. Mr. and Mrs. Arthur B. Coen, Jr. Mr. Edward C. Coffey Ms. Naomi Robins Cogan Mr. and Mrs. Edmund L. Cogburn Mr. and Mrs. James H. Cohen Cohen Family Foundation Lynne Cohen Foundation for Ovarian Cancer Research Coker Foundation Sue and Jim Cole Mr. Kermit D. Cole Estate of Marguerite Cole Mr. Robert Cole The Ashley Fister Cole Foundation Mr. and Mrs. Cosby A. Coleman Arlette & William J. Coleman Family Foundation Inc. Colemont Brokerage Group, Inc. Colemont Insurance Brokers of Texas, L.P. Mr. and Mrs. Frank J. Collazo Estate of Virginia A. Collet Mr. Curtis J. Collins Dr. and Mrs. Charles Colvin Combined Federal Campaign of the Texas Gulf Coast Comiskey Foundation Commonwealth Foundation for Cancer Research Commonwealth Properties, Inc. The Community Foundation for Greater Atlanta, Inc. Community Foundation for Southeastern Michigan Community Foundation of Brazoria County Community Foundation of Greater Memphis Community Foundation of Jackson Hole ConAgra Foods, Inc. Concentra Health Services The Concordia Lutheran High School National Honor Society Mr. and Mrs. Michael M. Cone The Coneway Family Foundation Conley Lott Nichols of Texas, Inc. Mr. and Mrs. Don Conlon Mr. and Mrs. H. Frank Connally Mr. and Mrs. John B. Connally III Mr. and Mrs. Mark M. Connally Mr. Michael K. Connally Mrs. Charlyne S. Connelly Mr. Jeffrey Connelly Mr. and Mrs. Marvin G. Conner

Dr. Coyle S. Connolly Mr. and Mrs. Robert C. Connor ConocoPhillips Mr. Joseph John Conradi Conseco Life Insurance Company Continental Property Mr. Marcus P. Contreras Mr. James R. Contway Phil and Suzie Conway Mr. and Mrs. Brian C. Cook Mr. and Mrs. John W. Cook Dr. Milton N. Cooper Frederick E. Cooper & Helen Dykes Cooper Charitable Foundation Cooper Industries Foundation Mrs. Patricia A. Corbett Mr. and Mrs. Thomas R. Corbett Cordillera Energy Partners II, LLC Estate of Edna E. Corey Dr. Yvonne C. Cormier and Mr. Rufus Cormier, Jr. Mr. and Mrs. Leonard Cornelius Cornerstone Acquisition and Management Corporate Retreats International Mr. Jose Correa, Jr. Mr. and Mrs. Charles A. Correll Mr. Ed W. Corriston in memory of Danette Corriston Dr. and Mrs. James A. Corwin Mr. and Mrs. K. Mark Cory Cory’s Unlimited, Inc. Shirley and J. B. Coskey Mr. Steve J. Cosmos Cothron Partnership No. 2 Cheryl and David Cotner Ms. Mariana P. Cotten Cotton Club Collection Mr. and Mrs. Warren C. Coughlin Court Reporter’s Clearinghouse Mr. John P. Courtney Estate of Everette B. Cousins Ms. Janet Cousins Mr. and Mrs. Philip Cowan Mr. Edward J. Cowell, Jr. Mr. Edwin L. Cox The James M. Cox, Jr. Foundation CPNO Services, L.P. Mr. Jerry L. Crabtree Mr. and Mrs. Alan M. Craft Mr. and Mrs. Earle M. Craig, Jr. Ms. Janet Craig Robert S. Craine and Kathleen B. Craine Mrs. Mary M. Crandall Mr. and Mrs. Nance G. Creager Creative Retail Packaging Creator’s Canvas Cancer Research Foundation Credit Suisse Securities (USA) LLC Mr. Richard L. Crider Crockett Ranch Ms. Amanda B. Cross Mr. and Mrs. Christopher J. Crowley Mr. and Mrs. A. Norris Crownover, Jr. Mr. and Mrs. Robert P. Crozer CRR Ventures, LLC Mr. and Mrs. Thomas H. Cruikshank, Sr. The Crump Foundation Mr. Darwin Cruz Cubist Pharmaceuticals, Inc.

P a r t n e r s Mrs. Elaine R. Cullen Mr. and Mrs. Harry H. Cullen, Jr. Mr. and Mrs. Harry H. Cullen, Sr. The Cullen Foundation Mr. and Mrs. David Cummings Mr. M. Eugene Cummins Mr. and Mrs. Robert A. Curley, Jr. Mr. and Mrs. James R. Currie Mr. and Mrs. Keys A. Curry, Jr. Mr. and Mrs. David A. Curtis Mrs. Wanda C. Curtis Curtis & Son Vacuum Service, Inc. Mr. and Mrs. Paul S. Curtiss Mr. and Mrs. Michael J. Cyrus Cytogen Corporation D. E. Harvey Builders Dadeks Machine Works Corp. Mr. and Mrs. Thomas R. D’Agnes Mr. and Mrs. Alan C. Dahl Daiichi Pharmaceutical Corporation DaimlerChrysler Corporation Fund Dako Dallas Jewish Community Foundation Mrs. William E. Dalton L. B. Danford Charitable Trust Dr. Wendell D. Daniels Marjorie M. and William R. Daniels Dannenbaum Engineering Corporation Mr. and Mrs. Philip I. Danze Mr. and Mrs. Michael W. Dardick Mrs. Charline Dauphin The Sidney and Charline Dauphin Foundation Mr. and Mrs. Robert M. Davenport Mr. and Mrs. Solomon D. David, Jr. Mr. and Mrs. Bruce G. Davidson Estate of Robert V. Davidson The M. N. Davidson Foundation Butch and Tammy Davis Estate of Ira Winfield Davis Mr. and Mrs. J. Morton Davis Mr. Kenneth W. Davis, Jr.

Mr. and Mrs. Leon Davis Mr. and Mrs. Mark Davis Colonel and Mrs. Michael Davis Mr. and Mrs. Michael R. Davis Mr. and Mrs. Tracy Lee Davis Sam & Freda Davis Charitable Trust The Charles & Melissa Davis Foundation Davis-Lynch, Inc. Mr. and Mrs. Decker Dawson Mr. and Mrs. Robert S. Dayton Dayton Foundation Depository Inc. Mrs. Mary Wallace de Compiegne Mr. Donald De Line Mr. and Mrs. Henry C. Dean Ms. Rhonda B. Dean and Dr. Michael Pad Mr. and Mrs. Chad C. Deaton Mrs. Jean E. DeCicco Myrna and Ray Deckert Mr. and Mrs. Michael E. Dee Mr. and Mrs. Michael W. Deeds Deepwater Property Management LLC Mr. and Mrs. Michael L. Deese Mr. Brad G. Defenbaugh Mr. and Mrs. Ronald B. Degenhardt Mr. and Mrs. Myron B. Deily Rafael del Barrio Del Sol Food Co., Inc./Briannas DeLeon Middle School, McAllen, Texas Dr. and Mrs. Lance A. Dell Ms. Susan D. Dell Ms. Jenny Demarest Denman/Newman Foundation Denver Biomedical, Inc. Denver Foundation Mrs. Charlotte J. Der Garry Dermatology Foundation Dernick Resources, Inc. Mr. Michael Deshotel Devon Energy Corporation DFB Pharmaceuticals, Inc. Mr. Ugo di Portanova

DialAmerica Marketing, Inc. Mr. and Mrs. George Diamantis DiaSorin Inc. Mr. Ronald J. Dickens Mr. and Mrs. Roland Dickey Mr. Ernest J. Dickinson Mr. and Mrs. Chester E. Dickson Sunny Adair Dickson Mr. and Mrs. John P. Dieter Dr. and Mrs. John DiGiovanni Ms. Lucy Dikeou Mr. Perry A. Dillon, Jr. Mr. and Mrs. W. Lyman Dillon Discovery International Discovery Toys, Inc. Shanon and Lori DiSorbo Dr. and Mrs. Austin L. Dixon DKG Foundation Mr. and Mrs. Hugh C. Dobbins Mr. Randall W. Dobbs Dobson Properties The Dodge Jones Foundation Mr. and Mrs. Mark A. Doering Mr. and Mrs. Edward D. Doherty II Ms. Debora Dolan Mr. Leland A. Dolan Mrs. Beverly Dolinsky Julia and John Dombrowski Mr. and Mrs. Thomas E. Dompier Mr. and Mrs. Ben A. Donnell Nina H. Donnelley Mr. and Mrs. Patrick R. Donnelly Don’s TV & Appliance, Inc. Mr. and Mrs. Jeffery D. Dooley Mr. and Mrs. William J. Dorè, Sr. Mr. and Mrs. Benjamin L. Doskocil The M. S. Doss Foundation, Inc. Mr. and Mrs. Gregory K. Douglass Mr. and Mrs. Sam P. Douglass Dr. and Mrs. Gordon O. Downey Downman Family Foundation Mr. and Mrs. Robert J. Doyle

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Mr. and Mrs. William E. Dozier Mr. and Mrs. Gerald Drake, Jr. Mr. and Mrs. Tommy J. Drescher Mr. and Mrs. Patrick D. Drew II Mr. and Mrs. William E. Dreyer Alfonso and Mary Duarte Mr. and Mrs. Melvin Dube Oscar and Loretta Dube Hayward (Duke) and Mary Ducharme Duda Family Foundation Mr. and Mrs. Howard Dudley Mr. Robert Dueease Mr. and Mrs. Fred F. Dueser Duke Energy Foundation Mr. and Mrs. Baxter W. Dunagan Ms. Kathleen Dunagan Dunagan Farms Mr. Donald G. Dunbar, Jr. Mr. and Mrs. Charles W. Duncan, Jr. Ms. Genevieve L. Duncan and Mr. Keith D. Snodgrass Jeaneane B. Duncan Mr. Robert L. Duncan Mr. and Mrs. Robert Duncan Mrs. Mary A. Dundas Mr. and Mrs. Archie W. Dunham The Honorable and Mrs. Caswell J. Dunlap Dunn Family Foundation of Florida John S. Dunn Research Foundation Mr. and Mrs. W. McComb Dunwoody DuPont Mr. and Mrs. John L. Dupre III Duro Bag Manufacturing Company Mr. and Mrs. H. J. Durrett, Sr. Mr. Alan J. Dworkin Theresa Dwyer Mr. and Mrs. Paul Dye Mr. and Mrs. Joe R. Dyer Mrs. Lois W. Dyk Mr. and Mrs. Gregory B. Dykes Dynamic Color Solutions Dynamic Orthotics and Prosthetics, LP

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Lifting the Burden Making a generous gift of $2 million, Paul Beck established the Andreas Beck Inpatient Palliative Care Unit in memory of his father. Palliative care focuses on improving the quality of life for patients and their families by reducing the physical and emotional burdens of illness. It involves symptom management, supportive counseling and advanced care planning. Often services are extended not only to patients, but also to children whose parents or care-giving grandparents are cancer patients.

New Monroe Dunaway Anderson Society Members September 1, 2005 – August 31, 2006

Established in 1995, the Monroe Dunaway Anderson Society recognizes individuals and families who have selected the programs at M. D. Anderson to benefit from a planned gift, such as a bequest, life insurance policy or other similar vehicles. Listed below are new members of the society who recently have named the institution in their estate plans. Estate of Verna M. Baird Estate of Margaret L. Bayhi Raymond J. Beach Marty Berg Estate of Patricia D. Bohan Estate of Paul D. Broussard Estate of Albert E. Buzek Mary E. Certain Estate of Leona C. Chicoine Joseph J. Conradi Mr. and Mrs. Everett B. Cousins* Andrea and Bob Crawmer Ruth Eleanor Cudé Estate of Gertrude H. Currie Estate of Bernard W. Detlefsen Estate of Jacqueline H. Dwyer

Estate of Frank H. Gabriel Estate of Charles Genite, Jr. Ivan Nicholas and Sara Garnica Goldstein Estate of Myra J. Graff Richard W. Gray, III Leroy B. Griffin Estate of Russell S. Grove, Jr. John C. Hardison Mrs. Janet Hayden Estate of Raymond A. Hoffmaster Estate of Evelyn H. Hoopingarner Gene and Patricia Hunter Joyce F. Jaffee Estate of Christine M. Jones Estate of Mildred H. Keith

Judith D. King Mr. and Mrs. Donald F. Knowlton Harvey L. Kowalsky Estate of Susan C. McDonald Dr. Milam E. Leavens Lewis A. Lester Estate of Elizabeth G. Little Auta Lockie Estate of Eleanor Maynard Estate of Sylvan Mellinger Estate of Phyllis Melnick Estate of Lillie Mae Mitchell Roland and Jane Moreau Ms. Penny Morriss Mr. and Mrs. David R. Owen Lisa Kelso Pennington

Estate of Charles A. Pickett Estate of Frankie M. Rich Estate of William A. Runnels, III Mr. and Mrs. Vincent G. Santucci Betty J. Schneider Estate of Gertrude Scott Estate of Leon B. Stinson Mary A. Striewski C. Allen Thames, Jr. Mr. John L. Turner Dr. Jose L. Valencia Estate of Josephine Walker Estate of Morris S. Wiginton, III Estate of Vernon C. Wiley David Williams *Deceased

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Mr. Mark E. Dyslin Mr. and Mrs. Ralph Eads III East Texas Communities Foundation Mr. and Mrs. J. Brandon Easterling Mr. and Mrs. Gerald L. Eastham Mr. and Mrs. S. Stacy Eastland Mr. and Mrs. Robert Eaves Dr. and Mrs. David J. Eckberg Mr. John R. Eckel, Jr. Mr. and Mrs. Jack P. Eckels ECO Resources, Inc. Mr. and Mrs. Robert L. Edenbaum Mr. William D. Edman Mr. Thomas Edmonds and Ms. Schuyler Richardson EDS Educational Concepts Group, Inc. Boni S. Edwards Edwards Consulting, Inc. Mr. and Mrs. Robert B. Egan Dr. and Mrs. Ralph D. Eichhorn Mr. and Mrs. Pete Eischen Jay and Lori Eisenberg Ms. Kim Eisenhour Mrs. M. Louise Eisworth Ms. Joyce H. Eiszner Mr. Robert H. Eklund

The Advance Team

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Employees of El Paso Corporation El Paso Corporation Elan Pharmaceuticals, Inc. Elgin Breeding Service, Inc. Eli Lilly and Company Eli Lilly and Company Foundation Mr. and Mrs. John W. Elias Mr. James A. Elkins, Jr. Ms. Leslie K. Elkins and Mr. Shannon B. Sasser Dr. Allen J. Ellender, Jr. Dr. and Mrs. Donald A. Elliott Mr. and Mrs. James E. Elliott Mr. and Mrs. Kenneth W. Elliott Mrs. Elnor S. Ellis Mr. and Mrs. James B. Ellis II The Ellison Medical Foundation Dr. Mohamed B. Elmongy Mrs. Nona Elmore Mr. Mark H. Ely Mr. and Mrs. William O. Emde Emdeon Corporation Mr. Leonard E. Emge Empowered Solutions Encap Investments L.P. Endocare Inc. Energen Corporation

2006 - 2007

The following individuals comprise a volunteer leadership board focused on advancing M. D. Anderson’s mission to eliminate cancer through community-based initiatives centered on basic science research, education and prevention of cancer. This year the focus has been on the Children’s Cancer Hospital at The University of Texas M. D. Anderson Cancer Center. Mr. W. H. Armstrong, III Mr. Brent Benoit Mr. Stuart Bernstein Mrs. Tali Blumrosen Mrs. Nancy Broudy Mrs. Paula Meek Burford Mr. William J. Campbell Mr. John Courtney Dr. Steven Dean Mrs. Shelly Dee Mr. G. Edward Deery Mrs. Denise D. Dunham Mrs. Leslie Easterling Mr. Jay S. Eisenberg Mrs. Jamison Faliski Mrs. Jill S. Gabbe Mr. Elliot Goldman Mrs. Licia Green-Ellis Ms. Carolyn Hansard Mr. R. Lee Harrell, Jr. Mr. Alan Helfman Mrs. Lourdes T. Hernandez Mrs. Shawn Hogan Mrs. Beth Williams Lee Mrs. Ann Lovasz 60

Mr. Scott McClelland Mr. Andrew D. McCullough, Jr. Mr. Connelly McGreevy Mr. Eric Meadows Mrs. Jayme Morgan Mr. Brian Murphy Mrs. Kathy O’Neal Ms. Debra Paxton Mrs. Mary Martha Pickens Mr. Ian C. Radomski Mrs. Sheryl W. Rapp Mr. Alan M. Rosen Mrs. Angela Teas Schroder Mr. Chad Scott Mr. Roben Sellers Ms. Jennifer L. Shufelt Mr. Roy M. Spence, Jr. Ms. Holly Stroud Mr. John H. Styles, Jr. Mr. Ignacio Urbieta, Jr. Mr. Adalberto Vara Mr. W. Temple Webber, III Mrs. Kathryn Hall Wilson Mr. Don Woo

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Energy Maintenance Services Group I, LLC EnergyQuest Management, LLC Ms. Cheryl A. Engelmann Engineered Plastic Components Mr. and Mrs. Randy R. Engstrom Entelco Foundation for The Home Ranch Entertainment Industry Foundation Enzon, Inc. EOG Resources Epigenomics, Inc. Mr. and Mrs. Mark J. Epley Mr. Robert M. Erbrick, Sr. Erie Community Foundation Mr. and Mrs. Sheldon R. Erikson Dr. and Mrs. Fred Erisman III Ernie Elliott, Inc. ERSA Partners Ltd. ESP Pharma, Inc. Mr. and Mrs. Wilmot J. Estes Ethicon Endo-Surgery, Inc. Ms. Elizabeth D. Evans Mr. Jim Evans Colonel John T. Evans Mr. and Mrs. Wendall C. Evans Mr. and Mrs. Carl B. Everett III Mr. and Mrs. S. Carl Everett Excalibar Minerals Inc. Executive Women International Exxon Mobil Corporation ExxonMobil Foundation Mr. and Mrs. Simon B. Eyles E-Z-EM Inc. Robert S. and Patti N. Fabris Mr. Robert Faehling Dr. and Mrs. Wayne A. Fagan Mr. and Mrs. Roberto Faith Estate of Harold M. Falik Patty and Larry Fallek Fannie Mae Foundation Mrs. Florence Farek The William Stamps Farish Fund Mr. Robert E. Farrell Mr. and Mrs. Thomas G. Farrier Mr. and Mrs. David S. Fast Mr. and Mrs. Charles C. Fatino Faxitron X-ray Corporation Federated Department Stores Foundation Dr. and Mrs. John P. Feighner Mr. and Mrs. Hill A. Feinberg Feinberg Foundation Inc. Mr. and Mrs. Alan D. Feld Mr. Bernard R. Felix Mr. and Mrs. Paul H. Felker Mr. and Mrs. Dillon J. Ferguson Mr. J. Philip Ferguson Fern Bluff Properties Mr. and Mrs. Lazaro H. Fernandez Mr. Francis C. Ferreira Mr. Melvin J. Ferreira Mr. Tom E. Ferrill, Sr. Mr. Peter F. Ferris Ferris LLP Mr. and Mrs. Jason L. Fertitta Mr. and Mrs. Julian Fertitta Mr. and Mrs. Tilman J. Fertitta Mr. John L. Fichter Fidelity Investments Mr. Bert Fields, Jr. Dr. Tina T. Fields

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2 0 0 5 – 2 0 0 6

The Fifth Business, Inc. Ms. Ann R. Figg V. O. Figge and Elizabeth Kahl Figge Charitable Foundation Mr. and Mrs. Jerry E. Finger Jerry and Nanette Finger Foundation Linda and Ronny Finger Foundation Finkelstein Foundation Mrs. Mary Ellen Finnegan First Horizon National Corporation First National Bank Albany/ Breckenridge First National Bank of Bastrop Dr. Ben R. Fisch Ray C. Fish Foundation Mr. Dan Fisher Mr. and Mrs. Donald F. Fisher Mr. and Mrs. Michael M. Fisher Mr. and Mrs. Robert B. Fisher, Jr. Mr. Larry Fishman Mr. William W. Fisk Mr. and Mrs. Lynn Fister Mr. and Mrs. James F. Fitzgerald, Sr. Ms. Ellen Flamm David and Judy Fleischer Ms. Lynda C. Fleming Flexmaster USA, Inc. Flight Attendant Medical Research Institute Mrs. Harriet H. Flora Dr. and Mrs. Hildegardo E. Flores Cherie and Jim Flores Ms. Maria C. Flores Florida Bond and Mortgage, Inc. Mrs. Patricia L. Flower Mr. Billy S. Flowers Mrs. Mariolivie G. Flume Mr. and Mrs. Patrick J. Flynn FMC Technologies Ms. Carolyn E. Fogg Miss F. Lavinia Fogle Foley’s Mrs. Bobbye M. Followill Dr. and Mrs. David S. Followill The Fondren Foundation Dr. Susan Foote and Mr. Stephen L. Feinberg Mr. and Mrs. Bill Foran Mr. and Mrs. Charles O. Ford Mr. and Mrs. Eric A. Ford Forest Pharmaceuticals, Inc. Mr. and Mrs. Bill Forney, Jr. Mr. Brad Forrester Estate of Elizabeth G. Forse Dr. and Mrs. Arthur T. Fort Mr. and Mrs. John F. Fort III Fort Worth Gear & Axle Ms. Betty L. Foster Mr. James E. Foster Mr. Kent S. Foster The Foundation For A Second Chance Foundation for Research Foundation for the Carolinas Mr. Greg Fourticq, Jr. Patsy and Greg Fourticq Mr. and Mrs. Earl L. Fowler, Jr. Mr. and Mrs. R. Alan Fox The Terry Fox Foundation Fox Rothschild LLP Mr. and Mrs. William Frakes Mr. and Mrs. Edwin H. Frank III Mr. and Mrs. Gerald Frankel

Mr. Barney M. Franklin, Jr. Franklin Bank E. A. Franklin Charitable Trust Frank’s International Ms. Lisa M. Frantz Fraternal Order of The Eagles Arie #3245 Mr. and Mrs. Michael E. Frazier Mr. and Mrs. Paul H. Frazier Mr. and Mrs. Norman D. Frede George and Marguarette Frederick Twilight and Marc Freedman Foundation Bebe Roberts Freeman Mr. Bradford M. Freeman Freeport-McMoRan Copper & Gold Inc. Freeport-McMoRan Foundation Freidman Industries, Incorporated Mr. and Mrs. Lloyd R. French, Jr. The Fretz Corporation Mr. Mark A. Frevert Mr. and Mrs. Harold Friedman Ms. Lauren G. Friedman Brian P. Friedman Family Foundation Mrs. Marie Louise Friendly Frontier Science & Technology Research Foundation, Inc. Frosch International Travel Frost Bank Mr. Harry R. Fruehauf III The Fruehauf Foundation Ms. Shara M. Fryer and Mr. Barry Silverman Fujirebio Diagnostics, Inc. Dr. Toshiya Fujiwara Fulbright & Jaworski L.L.P. Mr. Victor L. Fuller Mrs. Jeffrie Fulmer-Thomas and Mr. Terry L. Thomas Mr. and Mrs. James M. Funk Estate of John K. Funk Mr. and Mrs. William Furbush The Fuscone Family Foundation Mr. Harry J. Gabriel Mr. and Mrs. Harry J. Gabriel, Jr. Mr. and Mrs. Frank R. Gailor The Gaither Foundation Mr. Walter J. Gajcak Parents of Kevin M. Gallagher Barry and Kathy Galt Mr. and Mrs. Michael Gamson Mr. and Mrs. Robert A. Gardner, Jr. Mrs. Wanda M. Garner Mr. G. Waddy Garrett Mary Pendleton Garrett-Toma Mr. and Mrs. Kenneth N. Garrison Pamela and Wayne Garrison Dr. and Mrs. Gary M. Gartsman The Garver Foundation The Honorable and Mrs. William L. Garwood Mr. Thomas E. Gary Gary DeFord Investments Gary’s Tire & Auto Service, Inc. Mr. and Mrs. S. A. Garza Mr. and Mrs. Mike Gatewood The Gatewood Family Foundation Dr. Polly K. Gauthier and Dr. Jerry W. Gauthier Ned & Kim Gay Foundation Inc. Mr. and Mrs. Gibson Gayle Jr. Mr. and Mrs. Edward O. Gaylord

P a r t n e r s Gaylord Chemical Corporation Mr. and Mrs. Harold S. Gazan Gazan Quest for the Cure Foundation GE Commercial Distribution Finance GE Energy GE Medical Systems The Honorable and Mrs. Bruce S. Gelb Lawrence M. Gelb Foundation Inc. Mr. and Mrs. Phil Gellis A. S. Genecov Foundation Genentech, Inc. General Motors Acceptance Corporation Estate of Charles Genite, Jr. Genomic Health, Inc. Gen-Probe Incorporated Genzyme Corporation Mr. Everett George Mr. and Mrs. R. James George, Jr. Georgia-Pacific Corporation Mr. and Mrs. Richard H. Gerlach Mrs. Geraldine Gerling Mr. and Mrs. Glenn R. Gerloff Mr. David P. Gerow Mrs. Patricia P. Gevertz Charlotte Geyer Foundation Dr. John J. Ghidoni Shubhra Ghosh, M.D. Beth and Wayne Gibbens Mr. and Mrs. James A. Gibbs Mr. and Mrs. Gary F. Gibson Mrs. Joannette Giffin Mr. and Mrs. Julian C. Giglio The Honorable Joseph Gildenhorn and Mrs. Alma Gildenhorn Terry M. Giles and Kalli S. O’Malley Giles O’Malley Foundation Gilfin International Dr. and Mrs. Jack M. Gill Ms. Deborah J. Gillen The Gillette Company Mr. Jack D. Gillis Ms. Lisa Gingrich Ms. Frances E. Ginsburg Mrs. Jeanette M. Ginsburg Mr. and Mrs. Henry A. Gladstone Dr. and Mrs. Armand B. Glassman glassybaby LLC GlaxoSmithKline Mr. Thomas A. Glazier Glendale Boat Works, Inc. GlobalSantaFe Corp. GMAC ResCap Mr. and Mrs. James E. Goddard Charles B. Goddard Foundation Dr. and Mrs. Glenn A. Goerke Kelly Golat Melanoma Research Scholarship Fund Inc. Mrs. Carol S. Gold Mr. and Mrs. Robert D. Goldberger Linda and Ray Golden Mr. and Mrs. Richard Goldenberg The Goldhirsh Foundation Goldman, Sachs & Co. Golfers Against Cancer Golub Family Foundation Mr. Federico Sada Gonzalez Mrs. Nancy C. Good Mr. and Mrs. Elton F. Goodall Mr. and Mrs. Charles Goodman Mr. and Mrs. Marvin Goodman

The Honorable and Mrs. Roy M. Goodman The Marvin & Eleanor Goodman Foundation Mrs. Joyce Goodner Mr. L. W. Goodrich Mr. William J. Goodwin The Donald G. Goodwin Family Foundation, Inc. Mr. Steven L. Gordon Harry B. Gordon and Aileen B. Gordon Foundation The Berry Gordy Family Foundation Mr. and Mrs. Steve Goree Mrs. Cora Lee T. Gott Mr. Arthur D. Gowan Mr. and Mrs. Anthony Gracely Estate of Myra J. Graff Mrs. Dorothy A. Graham Mr. and Mrs. Doyle A. Graham Ms. Gene Graham Mr. and Mrs. Robert H. Graham Graham Brothers Partnership Mr. and Mrs. Hoke S. Grant, Jr. Mr. and Mrs. Joseph M. Grant Grasso Production Management, Inc Mr. and Mrs. Andrew E. Graves Mr. David E. Gray Mr. Ed T. Gray Mrs. Helen S. Gray Dr. and Mrs. Kenneth N. Gray Mr. Richard W. Gray III Mr. and Mrs. Roger K. Gray Greater Elgin Chamber of Commerce Greater Houston Community Foundation The Greater Kansas City Community Foundation Ms. Callie B. Green Mr. and Mrs. Curtis S. Green Mr. and Mrs. David Greenberg Mr. and Mrs. Jim Greene Mrs. Joyce B. Greene Mr. and Mrs. Michael S. Greene Greening Donald Co. Ltd. Mr. James H. Greer The Greeting Pen Company Mr. and Mrs. Mark Gregg Mr. and Mrs. Paul Gregory Mr. Robert Gray Gregory The Gregory Fund Mr. and Mrs. Gaynor G. Gremillion F. O’Neil Griffin Mr. and Mrs. John I. Griffin Mr. Ken W. Griffin Mr. Leroy B. Griffin Griffin Laboratories Mr. and Mrs. Guy W. Griggs Mr. and Mrs. H. James Griggs Mr. and Mrs. David M. Grimes II Ms. Nola N. Grimes Mr. and Mrs. Gerald Grinstein Mr. and Mrs. George E. Grobowsky Estate of Willie Katherine C. Groce Mrs. Billye Spicer Grogan Mr. and Mrs. Roy J. Grogan Roy J. Grogan Charitable Fund of the Community Foundation of North Texas Mr. and Mrs. Jenard M. Gross Marion & Louis Grossman Foundation Estate of Russell S. Grove, Jr.

Grover Family, LP Mrs. Helen K. Groves Mr. Robert Gruy GSD&M GSEP 2005 Realty Corporation Mr. and Mrs. Malcolm J. Gudis Guerra Bros. Successors Mr. and Mrs. Clarence F. Guice Mr. and Mrs. Ben A. Guill Mr. and Mrs. W. Fenton Guinee, Jr. Gulf Coast Asphalt Company, L.L.C. Gulf Coast Mounted Shooters Gulf Investment Management, Inc. Gulf-Tex Co., Inc. Mr. Paul Gunderman Dr. and Mrs. Jack P. Gunter Ms. Janet Gurwitch Mr. and Mrs. Alfredo Gutierrez Mr. and Mrs. Peter J. Guzi Gynecologic Cancer Foundation Mr. and Mrs. Paul R. Haas Mr. and Mrs. Kirk S. Hachigian Hackett Family Foundation Dr. Frederick B. Hagemeister, Jr. Ed Haggar Family Foundation Mrs. Inda D. Hahn Mr. and Mrs. Tom L. Hail Mr. and Mrs. Saba S. Halaby Mr. and Mrs. James E. Haley Mr. and Mrs. Charles W. Hall Mrs. Constance H. Hall Mr. and Mrs. Gary L. Hall Mr. and Mrs. James E. Hall Mr. and Mrs. John R. Hall Mr. and Mrs. Willie M. Hall Employees of Halliburton Halliburton Company Halliburton Foundation, Inc. The Hamill Foundation Mr. and Mrs. O. C. Hamilton, Jr. Mr. Harold G. Hamm The Nancy and Alan Hamm Charitable Foundation, Inc. Mr. and Mrs. Adam Hamza Mr. J. Kenneth Hanak Mr. and Mrs. William M. Hancock, Sr. Handler Family Charitable Foundation Mr. Marshall J. Hanna Mr. and Mrs. Steve Hanna Robert H. Hannifin and Maxine B. Hannifin Trust Mr. and Mrs. L. David Hanower Mr. and Mrs. George G. Hansen Hansen Family Foundation Mr. Steve Hanshaw Dr. and Mrs. William F. Hanson Mr. and Mrs. Earle A. Hapke, Jr. Mr. and Mrs. Richard L. Harbin Mrs. Will L. Hardee William L. and Elnora Hardee Fund of Communities Foundation of Texas Mr. and Mrs. Bernard L. Hardiek Gregory and Jennifer Hardiek Mr. and Mrs. Peter T. Harding John Charles Hardison Mr. and Mrs. John Hare Mr. and Mrs. Calvin Hargrave Harlan Mr. and Mrs. James B. Harlow Ms. Anne M. Harper Mr. and Mrs. Curtis F. Harrell

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Endowed Distinguished Chairs* Gilbert H. Fletcher Memorial Distinguished Chair Kie-Kian Ang, M.D., Ph.D. Robert D. Moreton Distinguished Chair in Diagnostic Radiology given by W. A. “Tex” and Deborah Moncrief, Jr. Chuslip Charnsangavej, M.D. Alando J. Ballantyne Distinguished Chair of Head and Neck Surgery Gary L. Clayman, M.D., D.D.S. Hubert L. and Olive Stringer Distinguished Chair in Oncology in Honor of Sue Gribble Stringer James D. Cox, M.D. Hubert L. and Olive Stringer Distinguished Chair in Basic Science in Honor of Sally Stringer Benoit de Crombrugghe, M.D. R.E. “Bob” Smith Distinguished Chair in Cell Biology Isaiah J. Fidler, D.V.M., Ph.D. J. Taylor Wharton, M.D., Distinguished Chair in Gynecologic Oncology David M. Gershenson, M.D. Olla S. Stribling Distinguished Chair for Cancer Research Ellen R. Gritz, Ph.D. W. A. “Tex” and Deborah Moncrief, Jr. Distinguished Chair in Urology Herbert B. Grossman, M.D. Ruth Legett Jones Distinguished Chair Mien-Chie Hung, Ph.D. The Robert A. Welch Distinguished Chair in Chemistry William H. Klein, Ph.D. Jane and John Justin Distinguished Chair in Leukemia Research in Honor of Dr. Elihu Estey Larry W. Kwak, M.D., Ph.D. Charles A. LeMaistre Distinguished Chair in Thoracic Oncology given by W. A. “Tex” and Deborah Moncrief, Jr. Scott M. Lippman, M.D. Vivian L. Smith Distinguished Chair in Immunology Yong-Jun Liu, M.D., Ph.D. Roy M. and Phyllis Gough Huffington Clinical Research Distinguished Chair in Urologic Oncology Christopher J. Logothetis, M.D. Lockton Distinguished Chair in Pancreatic Cancer Research Craig Logsdon, Ph.D. John S. Dunn, Sr., Distinguished Chair in Diagnostic Imaging William A. Murphy Jr., M.D. Barnts Family Distinguished Chair for Cancer Research William K. Plunkett Jr., Ph.D. Senator A.M. Aikin, Jr. Distinguished Chair Raphael E. Pollock, M.D., Ph.D. Bud Johnson Clinical Distinguished Chair Jack A. Roth, M.D. Anne C. Brooks and Anthony D. Bullock III Distinguished Chair in Neurosurgery Raymond Sawaya, M.D. Gerald Dewey Dodd, Jr. Distinguished Chair in Diagnostic Imaging Paul M. Silverman, M.D. *As of January 2007 61

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Naming Opportunity Almost 200 supporters, including Gov. Rick Perry and former President George H.W. Bush, paid tribute to Peggy and Lowry Mays as M. D. Anderson celebrated the naming of the Lowry and Peggy Mays Clinic in spring 2006. Formerly the Ambulatory Clinical Building, the Mays Clinic was named to honor the couple for their generous support of M. D. Anderson through a $20 million gift to the institution’s research programs. The Mays celebrated the day with their children: Kathryn, Linda, Mark and Randall. Mr. and Mrs. Thomas F. Harrigan, Jr. The Grace and John T. Harrington Foundation Mr. and Mrs. John E. Harris Ms. Bettye W. Harrison Mr. David H. Harrison Mrs. Dorothy Myers Harrison Mr. and Mrs. James B. Harrison Ms. Mary Beth Harrison Ms. Sara B. Harrison Mr. and Mrs. T. E. Harrod Mrs. Thomas F. Hart Mr. and Mrs. Darrel Harvey M. L. Harvey Mr. and Mrs. George R. Harvick Mr. and Mrs. William C. Harvin The Hasey Foundation Mr. and Mrs. Edward M. Haspel Mr. Ned Haspel Dr. and Mrs. Samuel J. Hassenbusch III Mr. and Mrs. Ronald Hatfield The Hawn Foundation, Inc. Ms. Suzanne M. Haycook Mrs. Janet Hayden Mr. and Mrs. John E. Hayes, Jr. Mr. Charles H. Hayhurst Mrs. Betty J. Haynes Mr. W. Gene Hays Mr. and Mrs. Skip Healey Health Discovery Corporation Health is Wealth, Inc. Health Science Center for Continuing Medical Education Healthcare Financial Management Association Healthpoint, Ltd. Mr. and Mrs. Edward B. Heard Mr. and Mrs. Dennis Heath Mr. and Mrs. Jesse B. Heath, Jr. H-E-B

H-E-B Tournament of Champions Mr. and Mrs. Virgil Hebert, Jr. Mr. and Mrs. Jerry Hecht Mrs. Carole J. Heckman Mr. and Mrs. James H. Hefner, Sr. Mr. and Mrs. Robert A. Hefner III Ms. Barbara B. Heim Mr. and Mrs. Arnold F. Heinrich Mr. and Mrs. Michael J. Heinzman Mr. and Mrs. Rodney R. Heisch F. A. and Blanche Heitmann Foundation Estate of William G. Helis Helix Medical, Inc. Mr. and Mrs. Edwin Heller Mr. and Mrs. Jeffrey M. Heller Ms. Carrie J. Helm The Helmle-Shaw Foundation HelmsBriscoe Mrs. Jeanette Henderson Mr. and Mrs. John H. Hendrix The Dennis and Jennie Hendrix Foundation The Hendrix Family Charitable Fund of the Permian Basin Area Foundation Mr. and Mrs. Bruce E. Hendry Don Henley Mr. and Mrs. Dennis W. Hennen Mr. and Mrs. Jack Henry Janis and Randy Henry Mr. and Mrs. John A. Henry III Ms. Margaret W. Hensley Mr. and Mrs. Louis R. Henson Hera Foundation Bob L. Herd Foundation Ms. Lourdes T. Hernandez and Mr. Randall G. Hulet Mr. and Mrs. David T. Herr Mrs. Marjorie J. Herrero

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The Hersh Foundation Mr. and Mrs. Frank Herzog Mr. and Mrs. Marc Herzstein Mr. Max Hermann Herzstein Mr. Robert M. Hess Mr. Marvin H. Hester Mr. and Mrs. Jim Hetherly Mr. and Mrs. Howard H. Hewitt Hewlett-Packard Company Gloria and Ed Hicks Estate of Mary M. Hicks Hidden Pond Foundation Mr. and Mrs. Earl C. Higgins Mr. and Mrs. Norman R. Higgins Mr. William H. Higgins Mr. and Mrs. William G. Higgs Dottie and Bobby Hill Mr. Donald Murle Hill Mr. and Mrs. Jerry R. Hill Miss Lyda Hill Mr. Melvin J. Hill Mr. Stephen M. Hill Mr. William J. Hill Mr. and Mrs. William L. Hill Mr. and Mrs. Yerger Hill III Lyda Hill Foundation Hill, Parker & Roberson, L.L.P. The Hillcrest Foundation Hill-Rom Mrs. Mary S. Hinds Mr. Gilbert C. Hine Wendy and Jeff Hines Mr. Paul D. Hinson Dr. Randall D. Hinton Ms. Susan J. Hippler Hiroshima Cancer Seminar Foundation Hitachi, Ltd. Hitachi America Ltd. Mr. and Mrs. Harvey L. Hivnor Mrs. Mary Scott Hobdy Mr. Leland A. Hodges, Jr. Mr. and Mrs. Mark C. Hodges Hodges Fund of the Community Foundation of North Texas Mr. and Mrs. Allen R. Hodgkins The Hoeffner Foundation Mr. David D. Hoffman Mr. Raymond F. Hoffman Mr. and Mrs. Michael W. Hofmann Mr. and Mrs. Blake Hogan Mr. and Mrs. Dan Hogan III Mike Hogg Fund Mr. and Mrs. Forrest E. Hoglund The Hoglund Foundation Mr. and Mrs. John M. Hogue The Hojel-Schumacher Foundation Mr. and Mrs. James T. Hoke, Jr. Mr. and Mrs. D. Alter Holand Don L. and Julie Holden Foundation Mr. and Mrs. John B. Holdsworth Mr. and Mrs. Donald B. Holender Mr. and Mrs. Morris A. Holidy Mr. Ben Hollek, Jr. Mr. John A. Hollinshead Hollister Incorporated Mr. and Mrs. James J. Holloway Frank and Floy S. Holloway Charitable Trust Holly Corporation Mr. and Mrs. Ned S. Holmes

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Holt Atherton Educational Foundation, Inc. The Holthouse Foundation For Kids Dr. and Mrs. Waun Ki Hong Wayne Hooks Memorial Fund Estate of Evelyn H. Hoopingarner Mr. and Mrs. Alvin C. Hope, Jr. Mr. Bob C. Hopkins Mr. and Mrs. James T. Hopper Courtney and Bo Hopson Mr. and Mrs. James P. Horan Horizon Hobby Inc. Mr. and Mrs. David Horowitz Mr. Glen Hou Mr. and Mrs. Tommy Hou Mrs. Dorothy Knox Houghton Dr. Alvin E. Houser Housley Communications Inc. The Houston Comets Houston Endowment Inc. The Houston Exploration Company Houston Fire Department #93 Houston Golf Association Shell Houston Open Houston Jewish Community Foundation Houston Livestock Show and Rodeo Houston Pi Beta Phi Foundation Mr. Bonnie Howard, Sr. Bob and Aubyn Howe Foundation Mrs. Paul N. Howell Mr. and Mrs. Peter P. Howell Howell Family Foundation Dr. and Mrs. James A. Hower Andrew and Ingrid Hoyle Mr. and Mrs. Edgar W. Hubbard Mrs. Jere C. Hubbard Mr. Kenneth M. Hucherson Mrs. Adeline D. Hudson Mr. and Mrs. Dennis M. Hudson Mr. and Mrs. Bert L. Huebner Mr. John Huebner Mr. and Mrs. Daniel W. Huff, Jr. Mr. and Mrs. James L. Huffines The Honorable Roy M. Huffington Ms. Terry Huffington and Dr. Ralph Dittman Mr. Todd C. Huffman Mrs. Grace L. Hughes Mr. and Mrs. Thomas E. Hughes Mr. and Mrs. David C. Hull, Jr. Mr. and Mrs. Ralph T. Hull Mr. and Mrs. Hilmer C. Hultgren, Jr. Ms. Belinda Humphrey Mr. and Mrs. Gene E. Humphrey Mr. and Mrs. Scott Hunsaker Mr. Thomas M. Hunt Mr. and Mrs. Todd M. Hunt Hunt Family Foundation Hunt Petroleum Corporation Ms. Chan Leng Geok Hunter Mr. and Mrs. Robert C. Hunter The Hunton Group Dr. and Mrs. Robert B. Hurlbert Mr. and Mrs. Joel B. Hurley Mr. Kirby J. Hurley Mr. and Mrs. Charles E. Hurwitz Ms. Patricia M. Hutcheson Mr. and Mrs. William L. Hutchison, Sr. Ms. Nina C. Hutton Dawn and Leonard Huxtable

Mrs. Mary E. Huxtable Mr. and Mrs. Justin J. Hyland Dr. and Mrs. Geoffrey S. Ibbott IBM Corporation Mr. Robert Ideus Mr. and Mrs. John S. Ikard ImClone Systems Incorporated Mrs. Jane M. Immel IMPAC Medical Systems, Inc. Impact Communications, Inc. Indo-American Charity Foundation of Houston, Inc. IneXel Medical Strategy & Communications Infectious Diseases Society of America INO Therapeutics Institute for Continuing Healthcare Education Institutional Capital Corporation Integrated Therapeutics Group, Inc. IntegReview Ethical Review Board Integris Health Interactive Health Care, Inc. Interactive Network for Continuing Education InterContinental Houston International Bank of Commerce International Bank of Commerce Foundation International Gas Consulting, Inc. International Pipeline & Offshore Contractors Association, Geneva, Switzerland Introgen Therapeutics, Inc. Invivo Dr. Katie D. Irani Mr. and Mrs. Robert Isaacs Mr. and Mrs. Robert W. Ivey J. M. Huber Corporation Mr. and Mrs. James M. Jackson Mr. and Mrs. John C. Jackson II Mrs. Peggy D. Jackson Mr. and Mrs. Bryan K. Jacobs Ms. Patricia A. Jacobs The Charles E. Jacobs Foundation Mr. and Mrs. Gregg A. Jacobson Mr. and Mrs. William H. Jacoway Mr. and Mrs. A. J. Jacques Mr. and Mrs. Joseph D. Jamail Mr. and Mrs. Frank M. James Dr. and Mrs. Thirumalairaj Jayakumar Mr. and Mrs. L. Weldon Jaynes JBA Houston Foundation, Inc. Jefferies & Company, Inc. Mrs. Carol T. Jeffrey Mr. and Mrs. James O. Jenkins, Jr. Mr. and Mrs. Charles H. Jennings Dr. Rebecca M. Jensen and Mr. Steve B. Jensen Mr. Vaughan Jensen Dr. and Mrs. Gaylord A. Jentz Mr. James A. Jernigan Mr. George H. Jewell Nancy Glanville Jewell Jewish Community Foundation of Greater Phoenix, Inc. Jewish Federation of Cincinnati Jewish Federation of St. Louis Jim Dull Charity Golf Celebration JMT Properties, Inc. Joanne Hudson Tile & Stone, Ltd.

P a r t n e r s Joe Swartz Electric Company Mrs. Helen A. Joffrion Mr. and Mrs. Stanley M. Johanson John Daugherty Realtors Ambassador Brenda LaGrange Johnson and J. Howard Johnson Mr. C. G. Johnson Mrs. Charlotte A. Johnson Mr. David M. Johnson and Mrs. Theresa Johnson Mr. Jared R. Johnson Dr. and Mrs. Kleve C. Johnson Mr. and Mrs. Mark E. Johnson Mr. and Mrs. Robert W. Johnson Mr. and Mrs. Scot W. Johnson Mr. and Mrs. Walter E. Johnson Johnson & Family Foundation Johnson & Johnson Johnson & Johnson Services, Inc. The Robert Wood Johnson Foundation Mr. and Mrs. Edwin F. Johnston Elva Johnston Foundation Mr. and Mrs. Vance Jola Mr. and Mrs. A. V. Jones, Jr. Mr. and Mrs. Bob Jones Estate of Christine Montague Jones Mr. Clark Jones Mr. Frank L. Jones Mr. and Mrs. Gilbert O. Jones Mr. and Mrs. Jack G. Jones Mr. and Mrs. Jeffrey Jones Mr. and Mrs. Jon Rex Jones Mr. and Mrs. Louis D. Jones Mrs. Mary Louise Jones Mr. and Mrs. Theodore Jones Mr. and Mrs. Virgil Wayne Jones Gene & Jerry Jones Family Charity Mr. and Mrs. James T. Jongebloed, Sr. Mr. and Mrs. Byron Jordan, Jr. Mr. and Mrs. J. Michael Jordan Mr. John W. Jordan II Ms. Joyce M. Jordan Mr. and Mrs. Lenoir M. Josey II Joshua Engineering Group, Inc. Employees of JPMorgan Chase JPMorgan Chase & Co. JPMorgan Chase Foundation Mr. Damon S. Judd Mrs. Susan D. Juden The Junior League of Houston, Inc. JustGive Justiss Oil Company, Inc. Mr. and Mrs. Larry M. Kachler Sir Michael and Lady Kadoorie Mr. and Mrs. W. Barry Kahn Mr. and Mrs. John A. Kaler II Ms. Cecelia M. Kallina Amy Kalmbach Mr. and Mrs. Jerry Kane Mr. and Mrs. Chris Kanoff Ms. Michelee Kanz Mr. and Mrs. Edward Kapelanski Joan and Marvin Kaplan Mr. and Mrs. Neal Kaplan Robert and Terri Kaplan Mr. William J. Kaplan Kappa Alpha Psi Fraternity Karen Bess Builder LLC Karl Storz Endoscopy-America, Inc. Mr. and Mrs. Nalin Karunaratne Mr. and Mrs. Arnold Kasmiersky, Jr. Mr. Marshall P. Kath

Abraham J. and Phyllis Katz Foundation The Rosalie Katz Family Foundation, Inc. Mr. and Mrs. Dick Kaufman The Kayser Foundation KD for Kids, LLC Mrs. Donna Keeling Dr. Ralph Keen The Honorable and Mrs. James L. Keffer Mrs. Carole P. Keiffer Mr. and Mrs. Robert W. Keiningham Mr. and Mrs. Herbert D. Kelleher The Joan and Herb Kelleher Charitable Foundation Mr. and Mrs. Peter G. Keller Mr. and Mrs. William H. Keller Mr. and Mrs. John F. Kelley Mr. Russell T. Kelley Mr. and Mrs. Joseph Kellman Major and Mrs. Hunter R. Kellogg Dr. Robert R. Kellogg, Jr. W. K. Kellogg Foundation Kellogg Health Scholars Program Mr. Jeff Kelly Mr. and Mrs. Richard J. Kelly Susie and Pat Kelly Mr. Garth D. Kemp Kemp Foundation Mr. and Mrs. Jack Kendall Kenmont Capital Partners, L.P. Mr. and Mrs. Garland M. Kennedy, Sr. Mr. J. Christopher Kennedy Mr. and Mrs. Richard Kennedy Dr. and Mrs. Vernon E. Kenner Kenneth Lamb Construction Co. Kenneth W. Cory, Ltd. Ms. Jill F. Kenney The Kent Foundation Keown Charitable Foundation Dr. and Mrs. Matthew M. Kershisnik Mr. and Mrs. Albert Kessler Mr. and Mrs. David B. Kesterson Mr. and Mrs. George F. Kettle Ms. Anna S. Kibbe Mr. and Mrs. M. Don Kidd Kidney Cancer Association Dr. Jacqueline Kieff and Dr. Elliott Kieff Mr. and Mrs. Young S. Kim Mr. and Mrs. John Z. Kimberlin, Jr. Kimberly-Clark Corporation Mr. and Mrs. Marvin P. Kimmel Mr. and Mrs. Robert A. Kimmel Sidney Kimmel Foundation Ms. Dorothy Holt Kimsey Mrs. Denise M. King Mr. Duane King Mr. Michael P. King King IV A Day 5K King Systems Corporation Kinghorn, Driver, Hough & Company Mrs. Warren C. Kingsbury Kingwood High School Youth Against Cancer Club Mr. and Mrs. Jack L. Kirby The Klabzuba Family Foundation Mr. and Mrs. Roger L. Klasse Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation Mr. and Mrs. Alan A. Kleier Mr. and Mrs. Melvyn N. Klein Alvin A. and Roberta T. Klein Trust Ms. Meredith A. Kliewer Mr. and Mrs. William P. Kliewer

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Endowed Chairs* M. G. and Lillie A. Johnson Chair for Cancer Treatment and Research James L. Abbruzzese, M.D. Paul and Mary Haas Chair in Genetics in Honor of Amanda Marie Whittle Michael Andreeff, M.D., Ph.D. Hubert L. Stringer Chair in Cancer Research Ralph B. Arlinghaus, Ph.D. Ben F. Love Chair in Cancer Research Richard R. Behringer, Ph.D. Frank T. McGraw Memorial Chair in Cancer Research Donald A. Berry, Ph.D. Frank T. McGraw Memorial Chair in the Treatment of Cancer Eduardo D. Bruera, M.D. Ferenc and Phyllis Gyorkey Chair for Research and Education in Pathology Janet M. Bruner, M.D. Robert C. Hickey Chair in Clinical Care Richard E. Champlin, M.D. Charles B. Barker Chair in Surgery Steven A. Curley, M.D. Rebecca Meyer Brown and Joseph Mellinger Brown Chair in Basic Science Research Sharon R. Dent, Ph.D. J. Ralph Meadows Chair in Carcinogenesis Research at Science Park John DiGiovanni, Ph.D. Boone Pickens Chair for Early Cancer Prevention Michele Follen, M.D., Ph.D. Ruth Harriet Ainsworth Research Chair in Developmental Therapeutics Emil J Freireich, M.D. Nellie B. Connally Chair in Breast Cancer Gabriel N. Hortobagyi, M.D. Kelcie Margaret Kana Research Chair Hagop M. Kantarjian, M.D. Mrs. Edward J. Kloess Mrs. Katharina Klouda Mr. and Mrs. A. John Knapp, Jr. Angela and Bob Knauss Dr. William J. Knebel Patricia L. Knebel Memorial Fund of The Pittsburgh Foundation Mr. and Mrs. Brady Knight Mr. and Mrs. Jason Knight Mr. Les W. Knight Mr. David B. Knoll Mr. George W. Knorr, Jr. Ms. Mary Louise Knowlton Jack Knox Robert W. Knox, Sr. & Pearl Wallis Knox Charitable Foundation Ms. Virginia S. Knull Mr. and Mrs. William H. Knull III Mr. and Mrs. Charles G. Koch Mr. David H. Koch Jeff and Gail Kodosky Mr. and Mrs. Kevin B. Koecher, Jr. Estate of Lillian C. Koehler

Dr. Kenneth B. McCredie Chair in Clinical Leukemia Research Michael J. Keating, M.D. Mosbacher Pediatrics Chair Eugenie S. Kleinerman, M.D. John G. and Marie Stella Kenedy Memorial Foundation Chair Rakesh Kumar, Ph.D. Betty B. Marcus Chair in Cancer Prevention Bernard Levin, M.D. Bernard W. Biedenharn Chair in Cancer Research Victor A. Levin, M.D. Irving and Nadine Mansfield and Robert David Levitt Cancer Research Chair Reuben Lotan, Ph.D. Mattie Allen Fair Research Chair Guillermina Lozano, Ph.D. Ann Rife Cox Chair in Gynecology Gordon B. Mills, M.D., Ph.D. Larry and Pat McNeil Chair in Radiation Oncology Honoring Dr. James D. Cox Radhe Mohan, Ph.D. David Bruton, Jr. Chair Garth Powis, D.Phil. Sue and Radcliffe Killam Chair Louise C. Strong, M.D. The Cullen Trust for Health Care Chair in the Department of Health Disparities Research David W. Wetter, Ph.D. Charles B. Barker Chair in Surgery Emeritus J. Taylor Wharton, M.D. Margaret and Ben Love Chair in Clinical Cancer Care in Honor of Dr. Charles A. LeMaistre W. K. Alfred Yung, M.D.

Ms. Margaret Koen Ms. Yasue Koezuka Mrs. Susan D. Kogel Kohler Company Susan G. Komen Breast Cancer Foundation (Dallas) Dr. and Mrs. Joseph S. Kong Kookaburra Foundation Linda and Robert Korb Dr. Barbara Kornblau and Dr. Donald J. Kornblau Mr. and Mrs. John Korry Mr. and Mrs. Herbert J. Korth, Jr. Kosan Biosciences Incorporated Mr. Charles R. Kott Mrs. Ronya Kozmetsky KPMG LLP Tom Kraft Dr. and Mrs. Richard B. Krakaur Mr. Mario L. Kreutzberger Ms. Vivian Kreutzberger Mr. and Mrs. William Kreykes KRG Capital Partners LLC

*As of January 2007 Ms. Linda R. Krienke Dr. Margaret L. Kripke and Dr. Isaiah J. Fidler Mr. and Mrs. Ronald D. Krist The Krist Foundation Dr. Iris M. Krupp Mr. and Mrs. Ed F. Kruse Mr. and Mrs. Paul W. Kruse The Gladys and Lee A. Krause Jr. Fund of the Lutheran Community Foundation KTM North America, Inc. Dr. Henry M. Kuerer Mr. and Mrs. Larry Kugelman Gene and Mary Lou Kurtz Mr. Robert R. Kurz Mr. and Mrs. George F. Kutzschbach Mr. and Mrs. Patrick Kuykendall Dr. and Mrs. Demos T. Kyrazis L & D Upholstery, Inc. Mr. and Mrs. R. Bruce LaBoon Mr. and Mrs. David J. Labrec Mr. and Mrs. Todd E. Lachenmyer Mr. Kent Lacy

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Endowed Distinguished Professorships * Annie Laurie Howard Research Distinguished Professorship Christopher I. Amos, Ph.D. P. H. and Fay E. Robinson Distinguished Professorship in Cancer Research Robert S. Benjamin, M.D. Birdie J. and Lydia J. Resoft Distinguished Professorship in GI Oncology Robert S. Bresalier, M.D. Edward Rotan Distinguished Professorship David L. Brown, M.D. Clifton D. Howe Distinguished Professorship in Pulmonary Medicine Burton F. Dickey, M.D. Monteleone Family Foundation Distinguished Professorship for Research of Bladder and Kidney Cancers Colin P.N. Dinney, M.D. The Hamill Foundation Distinguished Professorship in Honor of Dr. Richard G. Martin, Sr. Douglas B. Evans, M.D. Helen Shafer Fly Distinguished Professorship of Anesthesiology in Honor of Bertha Davis-Clark, M.D. Thomas W. Feeley, M.D. Virginia H. Cockrell Distinguished Professorship in Immunology Emeritus Jordan U. Gutterman, M.D. Sophie Caroline Steves Distinguished Professorship in Cancer Research Walter N. Hittelman, Ph.D. Robert R. Herring Distinguished Professorship in Clinical Research Patrick Hwu, M.D. Gloria Lupton Tennison Distinguished Professorship in Lung Cancer Research Ritsuko Komaki, M.D. Virginia H. Cockrell Distinguished Professorship in Immunology Jeffrey J. Molldrem, M.D. D.B. Lane Cancer Research Fund Distinguished Professorship in Leukemia Research Robert A. Newman, Ph.D. N.G. and Helen T. Hawkins Distinguished Professorship for Cancer Research Hui-Lin Pan, M.D., Ph.D. James E. Anderson Distinguished Professorship in Nuclear Medicine Donald A. Podoloff, M.D. Charles M. McBride Distinguished Professorship in Surgical Oncology Merrick L. Ross, M.D. Naguib A. Samaan Distinguished Professorship in Endocrinology Rena V. Sellin, M.D. Barnts Family Distinguished Professorship in Cancer Research Maria Suarez-Almazor, M.D., Ph.D. Hubert L. and Olive Stringer Distinguished Professorship in Cancer Research Randal S. Weber, M.D. Ruby E. Rutherford Distinguished Professorship Miles F. Wilkinson, Ph.D. Nylene Eckles Distinguished Professorship in Breast Cancer Research Dihua Yu, M.D., Ph.D. *As of January 2007 64

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Mr. and Mrs. Bert Ladd Ladies Auxiliary Ladies Leukemia League Mr. and Mrs. Mohammad Ladjevardian Lalor Foundation Mr. and Mrs. Steven E. Lambert Mrs. Gladiola Lampley Lancome Public Relations Mrs. Nancy F. Landa Landmark Resources, Inc. Mr. and Mrs. John R. Landon Mr. and Mrs. Jonathan M. Landon Mr. Richard S. Landrum Mr. and Mrs. Mark R. Landt Mr. Eric S. Lane Ms. Marilyn Bonner Lane Ms. Teresa G. Laneri Mr. and Mrs. John J. Langdon Mr. and Mrs. Mark Lange Lanier Middle School Mr. and Mrs. Ian M. Larkin Dr. and Mrs. Hugh Larriviere The Larry Brand Memorial Golf Tournament Mr. and Mrs. Edgar M. Larsen Mr. and Mrs. Henry J. Lartigue, Jr. Mrs. Linda M. Last Mr. and Mrs. Ben Latham Lauder Enterprises, Inc. Mrs. Elsa G. Laurel Mr. and Mrs. Oscar M. Laurel, Jr. Laurel Minerals, Ltd. Lawn Management Company Inc. Mr. Robert O. Lawrence Mr. and Mrs. Charles A. Lay Miss Dorothy Lay Mr. and Mrs. H. Ward Lay, Jr. Matthew E. and Debbie Layton Mr. and Mrs. Leon J. Leach Rita and Dick Leathers Dr. Milam E. Leavens Lecon, Inc. Mrs. Joe W. Ledbetter Scott and Helen Ledgerwood Mr. and Mrs. John A. Lee Mr. and Mrs. Eddie L. Lee Ms. Gin Ru Lee Mr. and Mrs. James H. Lee Ms. Kay L. Lee Dr. Linda D. Lee Mr. T. E. Lee Mr. and Mrs. William Lefkofsky The Legett Foundation Legge, Farrow, Kimmitt, McGrath & Brown, L.L.P. Lehman Brothers The Lehman Brothers Foundation Mr. and Mrs. Jay S. Leiber Mr. and Mrs. Min-Ji Lein Mr. and Mrs. Henry F. LeMieux Dr. and Mrs. Jerry B. Lemler Dr. and Mrs. Mark L. Lemmon The Lents Foundation Mr. and Mrs. Craig R. Lentzsch Mr. and Mrs. Joseph L. Leonard Mrs. Marty V. Leonard Mr. and Mrs. Gary T. Leseman Mr. and Mrs. W. Howard Lester The Leukemia & Lymphoma Society The Leukemia Research Foundation Ms. Wendy Leung

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Barbara Silven Levin Foundation, Inc. Levin, Fishbein, Sedran & Berman Rochelle and Max Levit Milton and Lee Levit Family/Max and Rochelle Levit Family Mr. Irwin L. Levowitz Estate of Meyer Levy Mr. and Mrs. James J. Lewis, Jr. Mr. and Mrs. Rodney R. Lewis The Kim and Rod Lewis Family Foundation For Hope & Charity Lewis Foundation Lexington Livestock Commission Mr. and Mrs. Michael L. Lexton Mr. David W. Ley Mr. Richard A. Leyendecker LGL Animal Care Products, Inc. Ms. Frann G. Lichtenstein Frann Gordon Lichtenstein Foundation Mrs. William C. Liedtke, Jr. Life-Tech, Inc. Ligand Pharmaceuticals, Inc. Mr. and Mrs. Donald E. Lightfoot Tom & Betty Lightsey Family Trust Lime Rock Management Leo and Bette Linbeck, Jr. Ms. Sandra Lincoln Ms. Marilyn Lindgren George B. Lindler Foundation Mr. and Mrs. Steven J. Lindley Edyth and Carl Lindner Mr. and Mrs. John P. Lindsay Mr. and Mrs. James C. Linford Mr. Jonathan S. Linker Linkup International Corporation Mr. Galen Linville Lippincott Williams & Wilkins Howard Lipshutz Mr. and Mrs. Joel M. Litman Mr. Ron Livingston LMA North America, Inc. Mr. Bryan Joseph Lobo Mr. and Mrs. Richard A. Lobo Mr. and Mrs. Jerry J. Lobrano Locke Liddell & Sapp LLP Lockheed Martin Corporation Lockton Family Foundation Mr. Norbert Lodygowski The Honorable Tom Loeffler and Mrs. Nancy Loeffler Mr. and Mrs. G. W. Loewenbaum Lohn Ranch, Inc. Mr. and Mrs. John H. Lollar III Lone Star Beef Processors, L.P. Lone Star Medical Products, Inc. Lone Star Region Vintage Chevrolet Club of America Mr. and Mrs. Dennis K. Long Gillson Longenbaugh Foundation The Longenbaugh Fund of the Vanguard Charitable Endowment Program The Longevity Foundation Mr. and Mrs. Harold Longhofer Mr. and Mrs. Harry J. Longwell Mr. Thomas L. Loratta Mr. and Mrs. Howard S. Lorch Mr. Richard E. Lore, Sr. Mr. and Mrs. Frank Lorenzo Lorman Education Services Mrs. Sara P. Loshak Mr. and Mrs. Alan W. Losinger

Mr. and Mrs. Rick Louden Louisiana Machinery Company, LLC Mr. Scott Louvier Mr. and Mrs. Gregory Lovasz Mr. and Mrs. Jeff B. Love Ben and Margaret Love Foundation Mr. Robert J. Lowe, Sr. Lowe Foundation Mrs. Carol Lowrance Mr. Dan E. Lowrance Mr. Lamar E. Loyd Dr. Guillermina Lozano and Dr. Gregory S. May Mr. and Mrs. Waldo Luedemann Mr. and Mrs. Manuel M. Luis, Jr. Mr. and Mrs. Robert W. Luker Mr. and Mrs. Fred H. Lunsford, Sr. Mr. and Mrs. Ted W. Lusher The Lustgarten Foundation for Pancreatic Cancer Research Mr. and Mrs. Robert P. Luvisi Mrs. Rosemary K. Lykos Ms. Nadine Lyle Estate of Rachel Lyman Lymphoma Research Foundation The Lyon Family Foundation Lyondell Chemical Company Mr. and Mrs. Daniel J. Lyons Ms. Julia C. Maas Ms. Deborah A. MacDonald Mr. Douglas G. Macdonald Mr. and Mrs. Ian M. MacDonald Mr. and Mrs. C. Robert Mace Mr. and Mrs. Roy W. Mace Mach Family Fund Ms. Kathleen Mack Mrs. B. John Mackin Mr. and Mrs. S. Todd Maclin MacPapers Incorporated Advised Fund Macy’s Mr. and Mrs. John P. Madden Mr. and Mrs. James A. Madden Mr. and Mrs. Wales H. Madden, Jr. Mr. and Mrs. C. Michael Maddox Mr. and Mrs. Louis E. Magne Mr. Frank C. Maguire, Jr. Mr. Wesley Mahone Robert W. Mahoney and Kathi Sibel Mr. and Mrs. Bob Mahr Mr. and Mrs. S. Lewis Main Mr. and Mrs. Frederic V. Malek Mr. James Mallak Mr. and Mrs. Donald C. Malli Dr. Meredith Mallory, Jr. Mr. and Mrs. Jean Malo Mr. and Mrs. Ray N. Malooly Mangen Family Charitable Foundation Mr. and Mrs. David D. Mann Neil and Kay Mann Dr. James A. Manning Mr. and Mrs. James D. Manning Manti Resources, Inc. Mr. James A. Manzi, Jr. Marathon Oil Corporation March of Dimes Birth Defects Foundation Estate of Betty B. Marcus Nancy Cain Marcus The Marcus Foundation Mr. and Mrs. Joe A. Marek The Marek Family

P a r t n e r s Mr. and Mrs. Rodney H. Margolis The Rodney H. and Judy E. Margolis Foundation Mr. and Mrs. I. W. Marks The Marks Charitable Foundation Mrs. Jo Marsh Mr. and Mrs. Stanley Marsh 3 Marsh & McLennan Companies, Inc. Mrs. Marie M. Marshall Mr. and Mrs. Frank D. Martell Mr. Casey J. Martin Ms. Donna R. Martin J. Stephen and Nancy Martin Estate of Josephine Williams Martin Mr. Ralph Martin The Robi Martin Foundation of G.R.A.C.E. John B. and Doris Casey Mason Mr. and Mrs. Edward Massman Master Tubulars, Inc. Mr. and Mrs. Charles E. Mathis Jennifer Matsui and Her Friends Dr. and Mrs. Toshimatsu Matsumoto Ms. Ethel Matsuno Mr. Harvey K. Mattel Mr. and Mrs. Kade L. Matthews Lucinda and Bill Matthews Ms. Rebecca Matthews and Mr. James F. Wallack Mr. Wayne L. Matus Mr. and Mrs. Edward R. Maunder Mr. and Mrs. Michael W. Mauritz Mr. and Mrs. Stephen P. Mawer Mr. and Mrs. John E. Maxwell Mr. and Mrs. W. Keith Maxwell III Ms. Melinda May Mr. and Mrs. Robert A. May Susan S. May and Andy Owczarek The May Department Stores Foundation Mr. and Mrs. Michael J. Mayell Mayer, Brown, Rowe & Maw LLP Roy and Nancy Mayers Mr. and Mrs. Kenneth R. Mayfield Mayne Pharma (USA) Inc. Mr. and Mrs. L. Lowry Mays Mays Family Foundation MBC Foundation MBNA Foundation MCA Charity Golf Tournament Dr. Bob McAmis Dr. and Mrs. Mark McArthur Mr. and Mrs. Robert H. McAuliffe, Sr. Mr. and Mrs. James R. McBride Mr. and Mrs. Gregory A. McCabe Michael T. McCann, D.V.M. Mr. and Mrs. Dennis W. McCarthy Mr. and Mrs. Garry McClenaghan Richard and Ella Mae McClendon The Honorable and Mrs. Austin McCloud Mr. William P. McClure Mr. and Mrs. B. Curtiss McClymond Mr. and Mrs. Hugh L. McColl, Jr. Linda and Howard McCollum The Red and Charline McCombs Family Foundation Mr. and Mrs. Jim McCool Mr. and Mrs. J. Philip McCormick McCormick & Company, Inc. Mr. and Mrs. Donald McCoy The McCrea Foundation Mr. Richard E. McCreary, Jr.

Mrs. Wanda S. McCulloch Mr. and Mrs. Andrew D. McCullough, Jr. Mr. Thomas B. McDade Mr. Clifton M. McDaniels The David McDavid Family Mrs. Beverly T. McDonald Estate of Susan C. McDonald Mr. and Mrs. Arthur L. McElmurry Mr. and Mrs. Jay C. McElroy McFadin Foundation Thomas W. and Patricia A. McGarity Mr. Bernard L. McGee Mr. and Mrs. William M. McGee Mr. and Mrs. Sutton McGehee Estate of Ina L. McGinnis Mr. Blaise L. McGoey John P. McGovern, M.D. Mrs. Karole O. McGovern Mr. Kyle A. McGraw Mr. and Mrs. Connelly T. McGreevy Mr. Hershel McGriff Mr. William A. McIntosh Mr. and Mrs. S. Barksdale McKay Ms. Cynthia S. McKernan Mrs. Lillian Herbelin McKibben Mr. and Mrs. Donald K. McKinney Ms. Mary E. McKinney McKinney & Cooper LLP Mr. and Mrs. James F. McKinnon Mr. and Mrs. W. David McLaughlin McLaughlin Ranch Ms. Anne McLean and Mr. John H. Williams Mr. and Mrs. Bruce W. McLean The Joseph R. McMicking Foundation Mr. and Mrs. Gordon McMillan Mrs. Kay R. McMillan Mr. and Mrs. Robert I. McMillan Don and Colletta McMillian Foundation Ms. Jeanie B. McMillin-VanWinkle Mr. and Mrs. William A. McMinn Mrs. James D. McMurrey The Robert and Janice McNair Foundation Mr. and Mrs. Doug McQuen Mr. and Mrs. A. W. Downing Mears, Jr. Mr. John W. Mecom, Jr. Medical Plaza Mobile Surveillance Medical Technology Management Institute, Inc. MedImmune Oncology, Inc., a subsidiary of MedImmune Inc. MedImmune, Inc. The Medipattern Corporation Medsite, Inc. Medtronic, Inc. The Meek Foundation Mr. and Mrs. Thomas R. Meeks Meeting Protocol Worldwide, LP Mr. Terry C. Mehaffie Mr. and Mrs. John Mehan Mr. Shmuel Meitar Mr. Zvi Meitar Estate of Phyllis Melnick Memorial Fund, Inc. Milton Ahrens Memorial Golf Tournament Dr. and Mrs. John Mendelsohn Mr. Andrew Mendez Mentor Corporation Merck & Co., Inc.

Mrs. Gail Merel and Mr. Christopher E. Dack Captain and Mrs. Hugh Merrill Merrill Lynch & Company Foundation Colonel and Mrs. Robert A. Mesick Metalforms, Inc. MetLife Foundation Estate of O. Frances Metz Mr. Stephen J. Metzger and Ms. Nancy Albertini Mr. and Mrs. Allen A. Meyer Estate of Evelyn M. Meyer Mr. and Mrs. Gary D. Meyer Mr. and Mrs. Jerry M. Meyer Mr. and Mrs. Kirby T. Meyer Ms. Nancy Ellen Meyer Barbara and Randall Meyer Mr. Steven H. Meyer MGI Pharma, Inc. Miami-Dade County, Florida District 6 Mr. and Mrs. David G. Miclette Micro Rentals, LLC Micro-Metals Incorporated Microsoft Corporation Microsoft Giving Campaign Mid-Con Energy Corporation Ms. Beatrice Mieth Ms. Laila Migally The Mike Doiron Legends of Friendswood Golf Tournament Mile High United Way Mr. and Mrs. E. Shelton Miles Millennium Pharmaceuticals, Inc. Beverly and Marvin Miller Mr. and Mrs. C. Donald Miller, Jr. C. John and Reva Miller Jan and Steve Miller Mr. Joel R. Miller Mrs. Mary Catherine Miller Ms. Polly G. Miller Mrs. Rhea J. Miller Mr. and Mrs. Vance C. Miller, Sr. Arnold and Suzanne Miller Charitable Fund The B.W. and Barbara Miller Foundation C. Wayne & Patricia J. Miller Foundation Steven and Sheila Miller Foundation Miller, Lewis, & Davenport, P.C. Colonel Billy J. Millis Mr. F. H. Mills, Jr. Dr. Keith R. Mills Mr. and Mrs. Sid Mills The Minneapolis Foundation Minton, Burton, Foster & Collins The Walter M. and Mary A. Mischer Foundation Mr. and Mrs. George P. Mitchell Mr. James R. Mitchell Mr. John R. Mitchell Estate of Lillie Mae Mitchell Mr. S. L. Mitchell The Cynthia & George Mitchell Foundation Mithoff Family Charitable Foundation Mr. and Mrs. Leonard F. Mitschke Mr. Richard H. Mixson, Jr. MMR Enterprises, Inc. Mr. and Mrs. Cougar D. Moats Mobil Foundation, Inc. Modestus Bauer Foundation

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Making Their Mark To honor two Houston philanthropists for their generous gift, M. D. Anderson named its newest research building the Gita and Ali Saberioon Molecular Markers Research Building. The Saberioons gave $10 million to M. D. Anderson’s South Campus Research Initiative in support of the Red and Charline McCombs Institute for the Early Detection and Treatment of Cancer. Mr. and Mrs. Haji V. Mody Mr. and Mrs. Leonard O. Moeller Joe and Mary Moeller Foundation James R. Moffett Family Foundation Dr. and Mrs. Radhe Mohan Mr. and Mrs. Irwin A. Molasky The Molbeck Family Foundation Dr. Edward R. Molina-Lamas Mr. and Mrs. Richard H. Molke, Jr. Mr. and Mrs. Alexander B. Molten Mr. and Mrs. W. A. ‘Tex’ Moncrief, Jr. William A. and Elizabeth B. Moncrief Foundation Dr. Patricia Montalbano and Dr. Francis P. Montalbano Mr. and Mrs. William A. Monteleone, Jr. Allison and Terry Montesi Mr. and Mrs. Ronnie Montgomery II Mr. Anthony R. Moore Mr. and Mrs. Boyd Bennett Moore Mr. and Mrs. Douglas D. Moore Mr. and Mrs. Eric A. Moore Mr. and Mrs. Hilmar G. Moore Jess and Beth Sanders Moore Mr. and Mrs. Preston Moore, Jr. Mr. and Mrs. Randy Moore Mr. and Mrs. Jack R. Mooring Mr. and Mrs. Lewis J. Moorman III Mr. and Mrs. Dan J. Moran, Jr. Estate of Louise J. Moran Mr. Richard J. Moran Mr. and Mrs. Sidney Moran Mr. and Mrs. Roland L. Moreau Mrs. Alma W. Moreton Mrs. Jane K. Morgan Estate of Joyce M. Morgan Morgan Foundation Morgan Stanley Ms. Joan Morgenstern Mr. and Mrs. Mark Morris

Morris, Lendais, Hollrah & Snowden Merna Morrison Mr. and Mrs. Lucian L. Morrison, Jr. Mrs. Sue Morrison Lucian and Nan Morrison Foundation Ms. Diane Mosbacher The Honorable and Mrs. Robert A. Mosbacher, Sr. Mosbacher Foundation, Inc. Bill and Janis Mosley The Jane P. and Wiley L. Mossy Jr. Foundation Ms. Kimberly Mount MTI Logistics, Inc. Mr. Edward A. Mueller Mr. Martin Mueller Mr. and Mrs. Robert C. Mueller Mr. and Mrs. Thomas J. Mulkey Mr. and Mrs. Timothy T. Mullen The Muller Automotive Group Estate of Ralph E. and Virginia J. Mullin Mr. and Mrs. Joe Mullis Multiple Myeloma Research Foundation Miriam and Jim Mulva Mr. and Mrs. Donald D. Muncy Murk Saxet Mr. and Mrs. Dennis E. Murphree Estate of Catherine C. Murphy Murphy Oil Corporation Mr. Archie L. Murray Mr. Art L. Murray Mr. John A. Murray, Jr. Mr. Robert N. Murray Musculoskeletal Transplant Foundation Mr. and Mrs. Raymond D. Musick Muskal Family Charitable Trust Mr. and Mrs. John M. Musolino Mustang Cat Mustang Golf Association Mr. and Mrs. Gray H. Muzzy

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In Her Honor For 20 years of Polo on the Prairie and more than $3 million in support, M. D. Anderson named the Polo on the Prairie Plastic Surgery Waiting Room in honor of Mary Anne McCloud. McCloud, who has been instrumental in orchestrating each year’s polo matches, cut the ribbon amid an audience of friends, family and M. D. Anderson leadership, including M. D. Anderson President John Mendelsohn, M.D. (left). An annual event, Polo on the Prairie has raised funds for various M. D. Anderson programs. Mr. and Mrs. Marvin B. Myers Arthur B. & Marion V. Myers Trust Fund Myriad Genetics, Inc. N. E. W. Electric, Inc. Mr. and Mrs. Lynn Nabers Nabors Corporate Services, Inc. Ms. Sandy Nachman Mr. and Mrs. Albert Narath National Brain Tumor Foundation National Breast Cancer Foundation, Inc. National Childhood Cancer Foundation National Comprehensive Cancer Network National Energy Group, Inc. National Foundation for Cancer Research National Kidney Foundation National Marrow Donor Program The National Organization for Rare Disorders National Pancreas Foundation National Philanthropic Trust National Sports Authority Mr. William V. L. Nations Natural Gas Partners, LLC Ms. Victoria Dale Nau The Navicor Group Ms. Mary Ida Naylor Ladan Nazari Mr. and Mrs. James P. Neeves Mr. and Mrs. David L. Neff Mr. and Mrs. Roy Neidig Mr. and Mrs. Dru A. Neikirk Mr. and Mrs. John C. Nelson

Mr. and Mrs. Thomas B. Nenninger Nereus Pharmaceuticals Inc. Mr. and Mrs. Joseph Neubauer Mr. and Mrs. Christopher J. Neugebauer Mr. and Mrs. Toby R. Neugebauer Mr. and Mrs. Donald R. Neumeyer Nevada Automotive Test Center New Chapter, Inc. New Process Steel Newfield Exploration Company Mr. and Mrs. Donald H. Newman NewQuest Properties Ms. Amy T. Ng Mr. and Mrs. David D. Nguyen Mr. and Mrs. Tri Nguyen Mr. and Mrs. Eric Niccum Mrs. Helen E. Nichols Mr. and Mrs. W. Robert Nichols III Mr. James F. Nick III Ms. Nancy A. Nickerson Dr. and Mrs. Lester I. Nienhuis Nike, Inc. Nix Patterson & Roach, LLP Mrs. Verna B. Noah Mr. and Mrs. William M. Noble, Sr. Noble Royalties, Inc. Mr. and Mrs. James L. Noel III Mrs. John P. Noel, Jr. Mr. and Mrs. John A. Nolan Nolan Bros. of Texas, Inc. Norman Frede Chevrolet Co. Norris Family Foundation The Northern Trust Company Mr. and Mrs. William D. Norton Mrs. Elizabeth Norwood

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Novartis Institutes for Biomedical Research, Inc. Novartis Pharmaceuticals Corporation Novartis Vaccines & Diagnostics Novo Nordisk Pharmaceuticals Inc. The Honorable James R. Nowlin Mr. and Mrs. Wade T. Nowlin, Jr. Mr. and Mrs. Wade T. Nowlin, Sr. William C. Nowlin, Jr. and Bettye H. Nowlin NPH Development NRG Texas LLC O. D. Rentals Mrs. Judy H. Oakley Mr. and Mrs. William D. Oates Mr. and Mrs. W. W. Oatman Mr. Raymond V. O’Brien, Jr. Mr. and Mrs. Robert E. O’Brien Obstetrical and Gynecological Associates, P.A. Occidental Petroleum Corporation Mr. and Mrs. Dennis J. O’Connor Bob and Sandy Odell Odin, Feldman & Pittleman P.C. Mr. Charles H. Odom Odyssey Healthcare of Conroe Beverly and Will O’Hara Mrs. Clifford Ohr, Jr. Ms. Leslie A. Ohr Mrs. Anna H. O’Kelley The Oklahoma City Terry Fox Run Mrs. Judith R. Okun Mrs. Carolyn B. Oliver Mr. and Mrs. David E. Oliver Mr. and Mrs. Lorrie T. Olivier Rodney and Mary Ann Olivier Olson-Kulka Foundation Olympus America Inc. Omni/PREX, S.L. Corporation Oncology Nursing Society Mr. and Mrs. Don R. O’Neal Mr. and Mrs. Ray L. O’Neal Ms. Joan G. O’Neil Mr. and Mrs. Brian E. O’Neill The Bunny & Jim O’Neill Foundation William J. and Dorothy K. O’Neill Foundation Mr. Earl M. Onitsuka Dr. Amir Onn Mrs. Robert R. Onstead The Robert R. and Kay M. Onstead Foundation Onyx Pharmaceuticals, Inc. John M. O’Quinn Foundation Mr. Morris A. Orden Mr. and Mrs. Paul F. Oreffice The Oreffice Foundation Organon Pharmaceuticals USA Inc. Orion Technology Inc. Ortho Biotech Products, L.P. Ortho-Clinical Diagnostics, Inc. Orthopaedic Associates, L.L.P. Mr. and Mrs. Richard L. O’Shields OSI Pharmaceuticals Mr. and Mrs. Guy J. Ossello Mr. and Mrs. Lee Roy Ott, Jr. Mr. and Mrs. Charles L. Ottinger, Jr. Mr. and Mrs. Jimmy Oustalet The Ovarian Cancer Research Fund, Inc. Ms. Anne Dale Owen

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Mr. and Mrs. David R. Owen Mr. and Mrs. Kenneth A. Owen Dian Graves Owen Foundation William and Ella Owens Medical Research Foundation Alvin and Lucy Owsley Foundation P&G Pharmaceuticals, Inc. The Pace Fund Mr. and Mrs. Orlando G. Padron Mr. and Mrs. Carter F. Page Panex Consulting, Inc. Mr. and Mrs. Bobby G. Pangle Parascope Ltd. Elsa U. Pardee Foundation Park Corporation The Park Foundation Mr. and Mrs. Charles R. Parker Dr. and Mrs. David L. Parker Mr. and Mrs. David Parker Mrs. Eugene J. Parker Mr. and Mrs. John M. Parker Ms. Mary E. Parker Mr. and Mrs. Richard H. Parker Mrs. Robert A. Parker Mr. Scott L. Parker Parker Drilling Company Mr. Josh H. Parr Mr. and Mrs. Dale Partain Mr. and Mrs. James F. Partridge Mr. and Mrs. Lawrence R. Paschich Mr. George W. Pasha III Mr. and Mrs. Malcolm Paterson Bob Patterson John and Nora Patterson Dr. Tad L. Patton Mr. and Mrs. Keith Paul Dr. and Mrs. James A. Paulson Ms. Debra Paxton Payne Foundation PDI PDL BioPharma Mr. and Mrs. Arthur W. Peabody, Jr. Peachtree Technology Associates, Inc. Ms. Julie Peak Pearland Volleyball Classic Ms. Lynn Pearson and Mr. Hector E. Ramirez Pediatric Brain Tumor Foundation of the United States Mr. and Mrs. Daniel A. Pedrotti Mr. and Mrs. Paul Peebles Mr. Bill Pegel Mrs. Arleen B. Pellegal Pemco Equipment Inc. Mr. Clinton D. Pendleton Richard and Kaye Pendleton Mr. and Mrs. Ken Pendray Ms. Lisa Kelso Pennington Pamela J. and James D. Penny Mr. and Mrs. John G. Penson PENTAX Medical Company Mr. and Mrs. John E. Peper PepsiCo Foundation Alexander Peralta, Jr., M.D., DABHPM, President, Palliative Medicine Consulting Services Peregrine Capital Management, Inc. Mrs. Bonnie Pereida Mr. and Mrs. Frederick M. Perkins The Dick and Judy Perkins Charitable Foundation

Mr. and Mrs. H. Ross Perot, Sr. The Perot Foundation Mr. and Mrs. Charles R. Perry Mr. and Mrs. Mills C. Perry Mr. and Mrs. Robert A. Perry Perry & Haas, L.L.P. Mr. and Mrs. Charles P. Peterman Roger and Bernadette Peters Mr. and Mrs. Timothy E. Peters Ms. Virginia L. Peters Mr. and Mrs. Greg B. Petersen Ms. Margaret L. Petersen Mr. Jim L. Peterson Jim L. Peterson Foundation Mr. Alfred J. Petit-Clair, Jr. PetroAlliance Services, LLC Petrochem Valve Inc. The Petroleum Club of Houston Foundation Mr. and Mrs. Jacob B. Petrosky Ms. June Pettus Pfeiffer Family Foundation Mr. and Mrs. David P. Pfeil PFI Constructors, Inc. Pfizer Foundation, Inc. Pfizer Inc. Ms. Marjorie L. Pflaum PharmAdura Pharmedica Communications Inc. Pharmion Corporation Mr. William J. Phelan Phelps Dodge Foundation Phi Delta Theta, Texas Delta Chapter (SMU) Philips Medical Systems Mr. Alan M. Phillips Ms. Jennie L. Phillips The Waite and Genevieve Phillips Foundation Mr. and Mrs. Ugo Piccagli The Marshall Pickard Family Mr. Robert S. Pickelner Mr. Boone Pickens Mr. and Mrs. Robert H. Pickens Mr. and Mrs. Jim B. Pickens Dr. and Mrs. Glynn John Pickens Mrs. Nelda Cain Pickens Mr. and Mrs. William C. Pickens Mr. and Mrs. Glenn A. Picquet Pie Town, Inc. Ed and H. Pillsbury Foundation Harriet Pillsbury Foundation Lt. Bryan Pinckney Pinnacle Polymers Mrs. Charlotte Pippin Ms. Linda L. Pirtle Pitch and Putt For A Cure Mr. Eric Pitcher Dr. Carl Plager Mrs. Madeline C. Plansky Mr. Richard M. Plato Ms. Christine A. Plonsky Mr. and Mrs. W. Craig Plumhoff Dr. and Mrs. William K. Plunkett PMI Specialists, Inc. Pogo Producing Company Polar-Ray Sunglasses, Inc. Mr. David G. Polis Mr. Elton Pollock Mr. and Mrs. Jose Polo Mrs. Lewis H. Pool

P a r t n e r s Mr. and Mrs. William L. Poole III Poongsan America Corporation Mr. and Mrs. Don E. Posey Mr. and Mrs. Brian Potashnik Mr. and Mrs. Michael J. Poulos Miss Judith L. Powell Mr. and Mrs. Thomas L. Powell, Jr. Mr. and Mrs. William W. Powell Don and Nancy Powell Foundation John and Jane Powers Foundation Tim and Katherine Pownell Prairie Star, Inc. Mr. and Mrs. Richard E. Prasek Mr. and Mrs. G. Heyward Preacher, Jr. Premier, Inc. Mrs. Sheila Prenowitz Mr. Arthur F. Preston Mr. and Mrs. Richard L. Preston The Roslyn and Michael Prevor Charitable Foundation, Inc. PricewaterhouseCoopers LLP Mrs. Ashley H. Priddy Mr. and Mrs. Michael D. Priddy Mr. and Mrs. Robert T. Priddy Pride International Pride Music Company Mr. and Mrs. David W. Prigmore Primary Capital Advisors, LC Primrose School of Bedford Mr. and Mrs. John E. Prine Mrs. J. Phillip Pringle Prostate Cancer Foundation Mr. and Mrs. Terry Pruden Prudential Foundation William H. Prusoff Foundation Mr. and Mrs. Barry T. Pryor Mr. Jessie D. Puckett, Jr. Mr. and Mrs. Eric J. Pulaski Mr. Tillman R. Pullig Mr. and Mrs. Robert E. Pullin Purdue Pharma L.P. Mr. Matthew A. Purdy Ms. Marjorie M. Purnell Mr. and Mrs. Joe E. Pybus, Jr. Quantum Gas & Power Quartz Mountain Aerospace, Inc. Quest Medical, Inc. Questar Corporation Quicksilver Resources, Inc. Ms. Kathleen L. Quirk Radiological Society of North America Mr. Michael G. Radler Dr. Thorir Ragnarsson The Ragsdale Foundation Mr. Javad Rahimian Mr. and Mrs. W. K. Rainbolt, Jr. Ms. Donna Rains Ms. Therese S. Ramirez and Mr. George C. Billings Ms. Kim E. Ramsey Mr. Ray Ramsey Mr. Edward Randall III Roberta K. Randall Charitable Foundation Jack & Beverly Randall Foundation, Inc. Randalls Food Markets Ranger Die, Inc. Mr. Salvatore A. Ranieri Mr. and Mrs. B. M. Rankin, Jr.

Mr. Bruce Ransom Mr. and Mrs. Bernard Rapoport Mr. and Mrs. Ernest D. Rapp Mr. and Mrs. Christopher D. Ratcliff R. Byron and Bobbie Ratliff Mr. and Mrs. Lyle J. Ratner Mrs. William H. Ratz Mr. and Mrs. Gerald Rauch Mr. and Mrs. Leonard Rauch The Stanley and Joyce Rawley Foundation Ms. Rhea Rawlings Mrs. Phyllis Ray Mr. Mike Rayburn Bessie L. Rayford Foundation Mr. and Mrs. Geoffrey P. Raymond Mr. and Mrs. Martin S. Raymond RBS Greenwich Capital Real Cure, Inc. Mr. and Mrs. John C. Reap Mr. and Mrs. O. H. Reaugh Mr. and Mrs. Thomas R. Reckling III Red Robin Restaurants Mr. Joe W. Redden, Jr. Mr. Fred J. Redeker The Redstone Companies Mrs. John C. Reece Mr. and Mrs. Charles A. Reed Mr. and Mrs. Joe G. Reed Ms. Margaret G. Reed Reed Exhibitions The Reed Foundation Mr. and Mrs. Samuel Reeves Ms. Alison T. Reid Mr. Brent H. Reid Mrs. James H. Reid, Jr. Mr. and Mrs. Joseph E. Reid Mr. and Mrs. Brian Reiley Mr. Owen A. Reischman Mr. and Mrs. John R. Reitz Reliant Energy Foundation Miriam and Tim Relyea Renaissance Charitable Foundation, Inc. Ms. Francy Renz Mrs. Betty Replogle Estate of B. J. Resoft Retina Research Foundation Mr. and Mrs. Laverne F. Reu Mr. and Mrs. Chris Reynolds Mr. James H. Reynolds Mr. and Mrs. Lawrence E. Reynolds Ms. Lois C. Reynolds Mr. and Mrs. Ted Reynolds Alice Kleberg Reynolds Foundation Mr. and Mrs. Carl T. Rhodes Mr. and Mrs. R. David Rhodes Mr. and Mrs. Hershel M. Rich Mr. and Mrs. Jerome A. Rich Martin D. & Barbara H. Rich Family Charitable Foundation Mr. and Mrs. Charles H. Richardson Mr. Chris Richardson Mr. and Mrs. Frank H. Richardson Mr. and Mrs. Richie Richardson Mr. and Mrs. Robert B. Richardson Mrs. Josephine H. Ricketts

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Endowed Professorships* Doctor R. Lee Clark Professorship Christian R. Abee, D.V.M Ransom Horne, Jr., Professorship for Cancer Research Bharat B. Aggarwal, Ph.D. Robert F. Fly Professorship of Surgical Oncology in Honor of R. Lee Clark, M.D. Frederick C. Ames, M.D. Hubert L. and Olive Stringer Professorship for Cancer Treatment and Research Wadih Arap, M.D., Ph.D. Blanche Bender Professorship in Cancer Research Richard J. Babaian, M.D. Ashbel Smith Professorship Robert M. Chamberlain, Ph.D. McCullough Professorship for Cancer Research Charles Cleeland, Ph.D. H.E.B. Professorship in Cancer Research Claudio J. Conti, D.V.M., Ph.D. Bao-Shan Jing Professorship in Diagnostic Imaging Ronelle A. Dubrow, M.D. John E. and Dorothy J. Harris Professorship in Gastrointestinal Cancer Research Lee M. Ellis, M.D. Kenneth D. Muller Professorship in Melanoma Research Adel K. El-Naggar, M.D., Ph.D. Hubert L. and Olive Stringer Professorship in Medical Oncology Elihu H. Estey, M.D. Ashbel Smith Professorship Varsha Gandhi, Ph.D. Ashbel Smith Professorship Bonnie S. Glisson, M.D.

Frances King Black Memorial Professorship for Cancer Research Elizabeth A. Grimm, Ph.D. Bessie McGoldrick Professorship in Clinical Cancer Research Jean-Pierre Issa, M.D. Felix L. Haas Professorship in Basic Science Marcus T. Kuo, Ph.D. Florence Maude Thomas Cancer Research Professorship Marvin L. Meistrich, Ph.D. Kathryn O’Connor Research Professorship Raymond E. Meyn Jr., Ph.D. United Energy Resources, Inc. Professorship Luka Milas, M.D., Ph.D. Helen Buchanan and Stanley Joseph Seeger Research Professorship Renata Pasqualini, Ph.D. John Q. Gaines Foundation Professorship for Cancer Research Alan J. Schroit, Ph.D. Ashbel Smith Professorship Robert A. Schultz, Ph.D. Kenneth D. Muller Professorship in Tumor Genetics Michael J. Siciliano, Ph.D. Anise J. Sorrell Professorship Peter F. Thall, Ph.D. Mattie Allen Fair Professorship in Cancer Research Elizabeth L. Travis, Ph.D. Dallas/Fort Worth Living Legend Professorship Stephen E. Ullrich, Ph.D. Ruth and Walter Sterling Professorship Cheryl L. Walker, Ph.D. Ashbel Smith Professorship Xifeng Wu, M.D., Ph.D. A Conversation with a Living Legend Professorship Edward Yeh, M.D.

*As of January 2007 Mr. and Mrs. Darrell Riddle Ms. Margaret Riecker Dr. and Mrs. Leonard M. Riggs, Jr. Mr. and Mrs. Robert Rigney Mr. and Mrs. Donald A. Rikard Mr. and Mrs. John W. Riley Ms. Michele Riley Mr. and Mrs. Patrick J. Riordan Mr. and Mrs. Craig M. Ripley Fannie E. Rippel Foundation Mr. James H. Rippy Rita Medical Systems, Inc. Mrs. Betty J. Riter Ms. Jane F. Ritter RNR Cross Family Foundation Mr. and Mrs. Braxton L. Roberts, Jr. Dr. R. Mills Roberts Ms. Sheryl L. Roberts Mr. and Mrs. Charles L. Robertson, Jr. Ms. Nancy G. Robinett and Mr. John J. Hamlin

Mr. Craig Robinson Mrs. Edgar A. Robinson Mr. and Mrs. J. O. Robinson The Roche Foundation Roche Laboratories Inc. Rock “N” Roll Coal Co. Mr. and Mrs. Mark E. Rodriguez Ms. Shannon F. Roethemeyer Mr. and Mrs. J. Hugh Roff, Jr. Roff Resources LLC Mr. and Mrs. Bruce L. Rogers Mr. and Mrs. Clarence B. Rogers Mrs. Donna L. Rogers Regina Rogers Mr. Steve K. Rogers Mr. Theodore C. Rogers Mr. Wesley Rogers Mr. and Mrs. William F. Rogers Robert M. Rogers Foundation The RoKe Foundation, Inc.

Mr. Robert L. Roloff Mr. and Mrs. Philip J. Romano Mr. and Mrs. Berthold Romberg Mr. Johnny J. Romero Mr. and Mrs. Avi Ron Ms. Rebecca A. Roof Mr. James W. Rooney Mrs. Sybil F. Roos William H. Roquemore Mrs. Ruth E. Roschke Dr. Bob Rosebrock Mr. and Mrs. Norman C. Rosen Dr. and Mrs. Walter M. Rosen Mr. and Mrs. Leonard B. Rosenberg Dr. and Mrs. Joseph Rosenstein Mrs. Doris Rosenthal Mr. and Mrs. William E. Rosenthal Mr. and Mrs. Allan Ross Mr. and Mrs. James E. Ross Ms. Jane R. Ross

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Too Cool to Smoke With substantial support from Aileen Gordon of Houston, M. D. Anderson’s “Too Cool to Smoke” program has reached nearly 10,000 elementary students. A component of M. D. Anderson’s Public Education Office, the “Tobacco Awareness Puppet Program” uses an interactive puppet show with a venue of a mall food court to explain the dangers of tobacco use to students in kindergarten through fourth grade. The goal is to equip children with skills to avoid tobacco and to make healthy lifestyle choices. Mrs. William H. Ross Rotary Club of Lake Conroe Foundation Arch and Stella Rowan Foundation, Inc. Rowling Foundation Roy Gurley Oil & Gas Jerry and Maury Rubenstein Foundation Mr. Robert G. Rubin Mr. Michael Gary Rudelson Nancy and Clive Runnells Estate of William A. Runnels III Damon Runyon Cancer Research Foundation Mr. and Mrs. Albert N. Rusche Dr. and Mrs. Joe B. Rushing Mr. and Mrs. Fred G. Russell Lynn and John Russell Russell & Smith Paul Rutenis Research Fund Mr. and Mrs. Keith Rutherford Mr. and Mrs. Patrick R. Rutherford, Jr. Mr. and Mrs. Jack B. Ryan The Ryrie Foundation Mr. and Mrs. Jin Roy Ryu Gita and Ali Saberioon Mr. Andrew E. Sabin Mr. and Mrs. Federico Sada Safeway Inc. Mr. and Mrs. Steven C. Salch Dr. Jean Samaan Earl C. Sams Foundation, Inc. San Antonio Area Foundation Mr. and Mrs. Adalio T. Sanchez Dr. Charles A. Sanders Jack and Mary Baldwin Sanders Mr. and Mrs. Roy I. Sandoval Sands Investment, Ltd.

George and Jennifer SanFilippo Ms. Shelly Sanford Mr. Joshua H. Sanger Sanofi-aventis Sanofi-aventis U.S. LLC Sanofi-Synthelabo, Inc. Ms. Gina Saour Mrs. Louisa Stude Sarofim Mr. and Mrs. Laurence R. Saslaw Dr. and Mrs. William C. Satterfield Saturn of New Orleans Mrs. Anita Sauers Mrs. and Mr. Louise W. Saunders G.B. & Charlotte A. Saunders Foundation, Inc. Mr. and Mrs. Dan C. Savage Mr. and Mrs. Omar A. Sawaf Dr. and Mrs. Raymond Sawaya SBC Employee Giving United Way Campaign Mr. Joe H. Scales Scanditronix Wellhofer North America, Inc. Ms. Laura B. Scarbrough Mr. and Mrs. Donald J. Schade Mr. Jack W. Schanck Mrs. Mary Ellen Scharffenberger Mr. David R. Scheihagen Schering-Plough Corporation Schering-Plough Foundation Ms. Janet B. Scherzinger Ms. Linda Schibi Dr. and Mrs. Donald R. Schinstine Mr. Donald T. Schlattman Mr. and Mrs. Thomas A. Schleigh, Jr. Schlumberger Technology Corporation Mr. and Mrs. Richard W. Schmidt

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The Honorable and Mrs. Harvey A. Schneider Mr. and Mrs. Steve Schneider Mr. and Mrs. Douglas W. Schnitzer Mr. and Mrs. Kenneth L. Schnitzer, Jr. Mr. and Mrs. Pat Schoeller Mrs. Hugo W. Schoellkopf III Dr. Scholl Foundation Mr. and Mrs. John D. Schoolfield Mr. and Mrs. Howard K. Schramm Mr. and Mrs. Leo J. Schramm Mr. and Mrs. Bruce H. Schremp Mr. Darryl Schroeder Mr. and Mrs. John D. Schubert Mr. Richard A. Schubert The Schwab Fund for Charitable Giving Mr. and Mrs. Joseph M. Schwartz Mrs. Rae Ceil Schwartz Schwartz, Page & Harding, L.L.P. Mr. and Mrs. Charles N. Schwarz, Jr. The Scienomics Group Paula and Jim Scofield Estate of Clarence R. Scogin Mr. Charles Scott Estate of Gertrude Scott The Thomas H. and Mayme P. Scott Foundation, Inc. The Red and Kathy Scott Trust Kim and Jeff Scrivener Mr. and Mrs. David J. Scudellari The Scurlock Foundation Seabo, Inc. Mr. and Mrs. Leo W. Seal Leo W. Seal Family Foundation Ms. Tara L. Seaman Mr. and Mrs. Edward C. See Mr. and Mrs. Ray R. Seegmiller Mr. Myron R. Sees Mr. and Mrs. J. Russell Seese Mr. and Mrs. Clayton E. Seidel Mr. and Mrs. Philip W. Seidenberger Seismic Exchange, Inc. Sell-Thru Services, Inc. Semiens Building Technologies The Sence Foundation Senterra Real Estate Group, LLC Mr. and Mrs. Joseph E. Seringer Mr. and Mrs. James A. Serritella Servox AG Mr. Dan Severinson Mr. and Mrs. Vernon A. Sevier, Jr. Mr. and Mrs. Carl Sewell Sewell Automotive Companies Sewell Village Cadillac Mr. George K. Sgagias Mr. and Mrs. Bobby S. Shackouls Mr. and Mrs. Peter H. Shaddock, Jr. Mr. and Mrs. Grover L. Shade Shady Grove Baptist Church Mr. Ronald G. Shafer Mr. and Mrs. Mel A. Shaftel Mr. Osman Shahenshah Ms. Kerry A. Shannon Mrs. Susan Shannon Mr. and Mrs. Tzu Fann Shao Mary Eliza and Park Shaper Mr. and Mrs. Marc J. Shapiro Ms. Betty J. Sharp Mr. Daniel Shaughnessy Mr. and Mrs. Paul J. Shaughnessy Rosemary and Joseph Shaughnessy

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Mr. and Mrs. Christopher A. Shaw Mr. David E. Shaw Mr. John K. Shaw Mr. and Mrs. Roy G. Shaw, Jr. Mr. and Mrs. Randall S. Shawell Mr. James H. Shea The Sheedy Foundation Mrs. Leslie K. Sheehan Sheffield Asset Management, LLC Mr. and Mrs. Myron M. Sheinfeld Shell Oil Company Shell Oil Company Foundation Louis and Ouita Shelton Mr. and Mrs. Marston C. Shelton Mr. and Mrs. John Shely Mrs. Lucille Sheng Mrs. Betty Jean Shepherd Mrs. Geraldine Sherman Mr. and Mrs. Robert E. Sherrill Dr. Daniel Shirey Mr. and Mrs. Clyde K. Shirley Mr. John S. Shivers, Sr. Mr. and Mrs. Mark B. Short Mr. and Mrs. Grady Lee Shropshire Ms. Jennifer L. Shufelt Ms. Ivana M. Shumberg Mr. and Mrs. George A. Shutt The Sidley Austin Foundation Mr. and Mrs. Lonnie Sieger Siemens Medical Solutions USA, Inc. Mr. and Mrs. David G. Siers Mr. and Mrs. Steve Sikes Ms. Heather Silver and Mr. Neil D. Grundhoefer Mr. and Mrs. Morton L. Silverblatt Mrs. Mary R. Silverthorne Mr. Charles M. Simmons Matthew and Ellen Simmons Simmons & Company International Harold Simmons Foundation Mrs. Suzy Sklar Simons Mr. and Mrs. Thomas G. Singley Ms. Pauline F. Sinopoli Ms. Dorothy O. Sinz Mr. and Mrs. William A. Sippy SIR Foundation Sirtex Medical, Inc. Mr. and Mrs. Michael B. Skalka Mr. and Mrs. Damir S. Skerl Mr. and Mrs. James W. Skidmore Ms. L. Susan Skiles Mr. and Mrs. Sam Skinner Mr. and Mrs. Samuel L. Skogstad Mr. William D. Skov Mr. and Mrs. Charles B. Slack Mr. and Mrs. Sidney Slavin Mr. Pieter Slik Mr. and Mrs. Melvin Sloan Mr. and Mrs. Robert I. Small Mr. and Mrs. Ken Smalley Mr. and Mrs. Frank M. Smeal Mrs. Judith B. Smerlis Smikis Foundation Mr. Doug Smith Mr. and Mrs. Ed A. Smith Ms. Elizabeth D. Smith Mr. and Mrs. Gerald B. Smith Mr. and Mrs. James A. Smith Mrs. Jeanette Smith Joe H. Smith and Kent H. Smith

Mr. and Mrs. L. R. Smith Mr. and Mrs. Lance Smith Mr. and Mrs. Lester H. Smith Mrs. Lura B. Smith Mr. and Mrs. Marc B. Smith, Jr. Mr. and Mrs. Marvin L. Smith Onnie Leach Smith Mr. and Mrs. Pomeroy Smith Mr. Randlow Smith Mr. and Mrs. Robert L. Smith Mr. and Mrs. Stephen Smith Mr. and Mrs. Stewart Smith Mrs. Vivian Smith Mr. and Mrs. W. R. Smith Mr. and Mrs. Wade C. Smith Dr. and Mrs. William P. Smith, Jr. Clara B. & W. Aubrey Smith Charitable Foundation Vivian L. Smith Foundation The William A. and Madeline Welder Smith Foundation Smith Barney Charitable Trust Smith, Graham & Company Smith Moore LLP Mr. and Mrs. Ray A. Snead, Jr. Mr. and Mrs. Robert G. Snead Mr. Robert H. Snead Mrs. Doris K. Snell Mr. and Mrs. Robert M. Snell Mr. Robert L. Snyder Nancy and John Snyder Foundation Sociedad Textil Lonia Corp. The Society for Surgery of the Alimentary Tract Mr. and Mrs. Daniel Sodersten Mr. and Mrs. Ken A. Somberg The Somekh Family Foundation Mrs. Terry Sonnevil SonoSite, Inc. Mr. and Mrs. Ignacio E. Sosa Mr. Charif Souki Sound Financial Solutions Mr. and Mrs. Charles M. Sours South Texas Money Management, LTD. Southeast Texas Enterprises, Inc. Ruth Parr Sparks Foundation Mr. and Mrs. Clay Spears Mr. and Mrs. Gregg Speck Mrs. Ronald L. Spector Spectrum Creations, L.P. Mr. William T. Speller Mr. and Mrs. Ron J. Spellman Mrs. Mary John Spence Mrs. Tancy Wynne Spence Ms. D. Laurie Spencer Mr. and Mrs. Keith Spickelmier Ms. Deborah A. Spink The Joel & Brenda Spira Foundation Dr. Craig A. Spletzer Mrs. Eldon G. Spletzer Mr. Jack B. St. Clair St. Mary Land & Exploration Company Stan and Suzanne St. Pierre Foundation Stamford Hospital Mr. and Mrs. Hayden Blake Stanford Mr. and Mrs. Charles B. Stanley Mr. and Mrs. Ted Stanley The Stanton Foundation Lois and George Stark

P a r t n e r s Mr. and Mrs. Morris C. Stark Stark Community Foundation Mr. and Mrs. William R. Starkey, Sr. State Employee Charitable Campaign Mr. Dean C. Stavinoha Ms. Marilyn P. Steed Mr. and Mrs. Will L. Steeves Stegmeier, LLC Mr. Albert W. Stein Mr. and Mrs. Ronald G. Steinhart Mr. John D. Stenson Mr. and Mrs. Eldee Stephens, Jr. Mr. and Mrs. A. Emmet Stephenson, Jr. Mr. Norm Steppe Ms. Rena Stevens Mr. and Mrs. John M. Stevenson Mr. John Stevenson and Ms. Robyn Rothman Keith & Mattie Stevenson Foundation Mr. and Mrs. H. Leighton Steward Alan G. and Kathy Kurtin Stewart Mr. Douglass M. Stewart Mr. and Mrs. Ward W. Stewart Stewart Title Guaranty Company Mr. and Mrs. Mark W. Stiles Mr. and Mrs. James R. Stimmel Mr. J. Michael Stinson Estate of Leon B. Stinson Mr. Bradford C. Stocki Gayle and Paul Stoffel Foundation Mr. and Mrs. John R. Stoika Mr. Michael J. Stonehocker Stonehocker Family Foundation Mr. Robert E. Storey, Jr. Mr. Robert E. Storey, Sr. Mrs. Lynda Stotsky Mr. and Mrs. Norman D. Stovall, Jr. Mr. George C. Stradley Strake Foundation Stratus Properties Inc. Mr. and Mrs. Joe R. Straus, Jr. Mr. F. W. Straw Mr. and Mrs. Ed J. Strayhorn Mr. and Mrs. Bruce Street, Jr. Mr. and Mrs. William M. Street Mr. Carl J. Streva The Strickland Family Foundation Mr. and Mrs. Robert P. Stringfellow Dr. and Mrs. David R. Strome Mr. Beeman E. Strong and Dr. Louise C. Strong Ms. Holly E. Stroud Mr. Tom Stroud Stryker Instruments Stryker Orthopaedics Mr. Timothy L. Stuart The Stuart Charitable Foundation The Joan Warren Stuart Foundation, Inc. Stuart-Griffin-Perlitz Foundation Mr. and Mrs. Dean J. Stuessy Mr. and Ms. John H. Styles, Sr. The Styles Company Mrs. Martha H. Styner Mr. and Mrs. Calvin H. Sugg, Jr. Mr. and Mrs. Paul R. Sullivan Mr. and Mrs. William A. Sullivan E. & B. Sullivan Foundation Mr. Joe Chat Sumner III Mr. and Mrs. Carl T. Sundbeck The Sunderland Foundation

Mrs. Margaret C. Sunderman Supreme Investments, Co. Judith A. Supworth Mrs. Dolores L. Sura Suros Surgical Systems, Inc. Susman Family Foundation Mr. and Mrs. L. Frederick Sutherland Dr. and Mrs. David A. Swanson Mrs. Donna A. Swartz Mrs. Alice M. Sweeney Estate of William G. Sweetman Mr. and Mrs. Virgil N. Swift Swift Energy Company The Swift Open Ms. Janet L. Swikard and Mr. Joe R. Davis Synapse Medical Communications LLC SYSCO Food Services-South Florida Mr. and Mrs. Antonio M. Szabo Mr. and Mrs. Michael Szymanczyk Sharon and J. Michael Talbert Mrs. Zoe Talbert Mr. and Mrs. Tony L. Talbott Mrs. Ahmad Taleghany Mr. and Mrs. Charles Talisman Mr. Alan H. Talley Mr. and Mrs. Kevin D. Talley Bob Tallman’s Charities, Inc. Mr. and Mrs. Denis R. Tanguy Tanox, Inc. Mr. and Mrs. Alan S. Taper Targa Therapeutics Corporation Mr. and Mrs. Paul Tashman Mr. and Mrs. Harry E. Tate The Charles W. Tate and Judy Spence Tate Charitable Foundation Mr. and Mrs. George L. Taubel III The Tauber Companies Mr. and Mrs. Richard J. Tavoso Mr. Hollis M. Taylor Mr. and Mrs. John N. Taylor Taylor & Hill Inc. Mr. and Mrs. Todd Teitell Telecom Pioneers Telik, Inc. Tema Oil & Gas Company Mr. and Mrs. Larry E. Temple Temple-Inland Foundation The Tensar Corporation Mr. and Mrs. Michael F. Terry Tex US TOO Texas American Resources Company Texas Capital Bancshares, Inc. Texas Federation of Business & Professional Women Foundation Texas Instruments Foundation Texas Neurofibromatosis Foundation Texas Nurses Association Texas Powder Coating Texas Prairieland Foundation TFWC Woman’s Club of Kingsville TGS-NOPEC Geophysical Company The Trout Group, LLC Mr. and Mrs. Malcolm J. Theobald Dr. and Mrs. Richard L. Theriault Theta Charity Antiques Show Mr. Edward E. Thiele Anna Belle P. Thomas Mr. and Mrs. Dwaine M. Thomas Mr. and Mrs. Gillis Thomas Mrs. Joye D. Thomas

i n

M a k i n g

C a n c e r

H i s t o r y

Hope on Wheels Hyundai Motor America, in partnership with CureSearch National Childhood Cancer Foundation, brought its Helping Kids Fight Cancer program to the Children’s Cancer Hospital at M. D. Anderson. Pediatric patients Astrid Camacho (left), Brendon Farmer, Armani Artis, John Jacob Ramirez and Lauren Henley added their handprints to the Hope On Wheels Santa Fe SUV, and area Hyundai dealers presented $50,000 to support clinical pediatric research under the direction of M. D. Anderson’s Joann L. Ater, M.D. Mrs. Patricia A. Thomas Mr. and Mrs. Robert W. Thomas Mrs. Sharon Thomas Mr. and Mrs. William S. Thomas John G. Thomas Family Foundation Thomas Jefferson University Mr. and Mrs. Brian J. Thompson Mr. and Mrs. Hall W. Thompson Mr. James G. Thompson Mr. and Mrs. Jon L. Thompson Ms. Patricia P. Thompson Peggy and Jere Thompson Thompson & Knight Foundation Thompson & Knight LLP Thompson Surgical Instruments, Inc. Mr. Laurence F. Thomson Thoracic Surgery Foundation for Research and Education Mr. and Mrs. Wilfred F. Thorne Mr. and Mrs. John Thornton Mr. and Mrs. Brian Thurman Tiburon Aviation LLC Mr. and Mrs. Bill J. Tidwell Mr. Rex W. Tillerson Tim Muellner Memorial Golf Tournament Timken Foundation of Canton Timm Medical Technologies, Inc. Mr. and Mrs. Cline A. Tincher TissueLink Medical, Inc. Dr. Teresa M. Todd and Dr. David L. Todd Tom Thumb Food & Pharmacy Mr. Bruce Tompkins Tony’s Prostate Cancer Research Mr. and Mrs. Morton L. Topfer Mr. and Mrs. Steve J. Torbeck Mr. and Mrs. Donaldo E. Torres Tosoh Bioscience, Inc. Total E&P USA, Inc. Mr. and Mrs. Gifford O. Touchstone Ms. Susannah W. Touzel Mrs. Sibyl V. Townes Mr. and Mrs. Mason L. Townsend

Toyota Motor Credit Corporation Mr. and Mrs. Clifford F. Traff Mr. and Mrs. William L. Transier Transmountain Oil Company, L.C. Mrs. Gilda M. Traywick Mr. and Mrs. D. Michael Trent Mr. Jeffrey D. Trevino Mr. Stanley H. Trezevant, Jr. Mr. and Mrs. Walter H. Triebel Mr. Stephen M. Trippe Dr. and Mrs. Barton C. Trover J. M. Trow Mr. and Mrs. Dean B. Truitt Mr. and Mrs. Jerry S. Trzeciak Mr. Byron Tuck Ms. Gaye U. Tullos Turnaround Management Association Mr. and Mrs. Jess R. Turner Turn-Tex Machine & Tool, Inc. Mr. Jack A. Turpin Mrs. Vernita J. Turpin Tyco Healthcare UBS Foundation USA UCB Pharma, Inc. Mr. and Mrs. James I. Uihlein Robert A. Uihlein Foundation Mr. and Mrs. Timothy J. Unger United States Amateur Ballroom Dancers Association (Houston Chapter) United States Cancer Pain Relief Committee United States Surgical Corporation United Way Capital Area United Way of Central Maryland United Way of the Texas Gulf Coast United Way of Tri-State UnumProvident Corporation Mr. and Mrs. Walter J. Unverferth Vivian and Ignacio Urbieta Jr. US E & O Brokers Colonel and Mrs. Roger R. Utley The V Foundation Mr. and Mrs. Ken Valach

Valco Instruments Company, Inc. Valence Operating Company Dr. Jose L. Valencia Mr. Daniel Valentine Mr. and Mrs. Michael G. Van De Ven Mr. and Mrs. Frank J. Van Deventer Mr. and Mrs. Henri Van Dierdonck Mr. George T. Van Horn, Jr. Mr. and Mrs. Tom Vance Mr. S. Will VanLoh, Jr. Ms. Nancy Vanmorkhoven Mr. and Mrs. William W. Vann The Vanneck-Bailey Foundation Mr. and Mrs. Adalberto Vara Mr. and Mrs. Michael K. Vargo Varian Medical Systems, Inc. Mr. and Mrs. Charles Varsel, Sr. Mr. and Mrs. Eugene H. Vaughan Mr. and Mrs. W. F. Vaughan Mr. and Mrs. Joseph C. Vawter The Family of Ray Velazquez Ventana Medical Systems, Inc. Mr. Samuel H. Vester, Jr. Veterans of Foreign Wars Herbert D. Dunlavy Post 581 Veterans of Foreign Wars of The Unit Jack F. Lee 9187 Viasys Healthcare Vick Family Foundation, Inc. Mr. Edward D. Vickery, Sr. Vicon Equipment Inc. Mrs. George F. Vietor Mr. and Mrs. Rakesh Vij Ms. Penelope S. Villars, CRNA, RN Mr. and Mrs. Michael Vinson Virchow, Krause & Company, LLP Mr. Michael Visconti VistaCare, Inc. Vitas Hospice Services, LLC Mr. and Mrs. A. J. Vogel Mr. Eric Vogel Mr. and Mrs. Gregory A. Vogt Mr. and Mrs. Kurt von Plonski Vornado Realty Trust

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A Passion for Education The Guerra family has contributed a total of $300,000 to M. D. Anderson’s Physician-Scientist Program. Guerra Brothers Successors, Ltd., contributed $100,000 in 2006 to the program, which gives working clinicians the time, financial resources, and mentoring from established researchers to develop independent, first-rate research projects. The gift reflects the Guerra family’s passion for the cause of higher education as well as their ongoing support of the institution. Pictured from left (front row) are: Gerry, Ann and Carmen Guerra, and Carmen E. and Luis Yzaguirre; from left (back row) are: Carlos, Sister, Hector, Maxine and Felo Guerra. Mr. and Mrs. Arthur M. Voss Mr. and Mrs. Mark L. Waage Wachovia Bank Susan Roberson Wade Memorial Car Rally Mrs. Cuba Wadlington, Jr. Mr. and Mrs. Robert Waechter Wagner & Brown Ltd. Estates of Lan Peck Wah and Dinney Ng Wah David and Holly Wainscott Mrs. Mary Pillsbury Wainwright The Honorable and Mrs. Stephen A. Wakefield Ruth E. Walborg Family Trust Mrs. Charlie Walden Mr. Thomas J. Walden In Memory of James J. Waldkirch Mr. and Mrs. Kirby D. Waldrop Mr. and Mrs. Foster Walker III Estate of Josephine Walker Mr. Ralph Walker Mr. Weldon Walker Mr. and Mrs. H. Dalton Wallace Mr. Jack Wallace Mary Lee and Jim Wallace Mr. and Mrs. W. Don Wallace Dwane L. and Velma Lunt Wallace Charitable Foundation Wal-Mart Foundation Wal-Mart Stores, Inc. Mr. and Mrs. F. Howard Walsh, Jr. Walsh Charitable Trust Ray Walsh Foundation Dr. and Mrs. Ronald S. Walters Mrs. Doris L. Walton Mr. Jerry W. Walton Mrs. Larry Walty Mr. and Mrs. James A. Waltz Mr. David I. J. Wang Mr. and Mrs. James Otto Warren, Jr.

Washington Mutual Employee Giving Mr. and Mrs. John J. Wasolek Steve and Sally Wasserman Waste Management, Inc. Watkins & Company, Inc. Waukesha-Pearce Industries, Inc. Samuel Waxman Cancer Research Foundation Mr. and Mrs. Philip F. Weaver The Gil & Dody Weaver Foundation Mr. and Mrs. John R. Webb Mr. and Mrs. Michael R. Webb The Webber Foundation Mrs. Patricia A. Weber Weber Family Foundation Mr. and Mrs. John T. Webster Joan and Michael Wechsler Austin W. & Audrey Weedn Foundation Mr. and Mrs. Richard W. Weekley Mr. Peter E. Weidler Weigel Enterprises, Inc. The Weingarten Schnitzer Family Emily Weingarten-Stein Mr. and Mrs. Kevin F. Weinrich Joseph Weintraub Family Foundation Mr. Ino G. Weiske Mr. Charles S. Weiss Ms. Laurie A. Weiss Mr. and Mrs. Herbert D. Weitzman Mr. and Mrs. G. Berkshire Welch The Robert A. Welch Foundation Carole and D. Brent Wells Employees of Wells Fargo Wells Fargo Bank, N.A. Mr. and Mrs. Timothy W. Wensits Mr. and Mrs. Eugene Werlin, Jr. Mr. and Mrs. Douglas E. Werner Mr. and Mrs. Steven L. Wessinger Mr. Robert M. West

Westbrook Metals Inc. Mr. Warren G. Wester Western Gas Resources, Inc. Mr. and Mrs. Alan D. Westheimer Mr. and Mrs. Wendell S. Westlake Westside Tennis Club Mr. and Mrs. R. Graham Whaling Wheeler Realty Inc. Mr. Michael R. Whiddon Mr. and Mrs. J. Mathew Whitaker The Whitaker Foundation Mr. and Mrs. Ty Whitcomb Mr. Bobby T. White Mr. and Mrs. James T. White Dr. Kathryn E. White and Mr. Glen Gee Mr. and Mrs. Richard W. White Mr. and Mrs. Russell White Mr. Stephen P. White White Star Energy, Inc. Mr. and Mrs. Lee Whiteaker Mr. and Mrs. Howard M. Whitehead Mr. John J. Whitehead Mr. and Mrs. Russell E. Whiteis, Jr. Mr. and Mrs. Lowell D. Whitlock III Mr. and Mrs. Danny M. Whitney Whittier Energy Corporation Mr. Carl L. Wickizer Mrs. Frances A. Wiese Ms. Cindy Wiggins Wild Well Control, Inc. Mr. and Mrs. Wayne T. Wiles Mrs. Helen B. Wiley Estate of Vernon C. Wiley Mrs. Dolores K. Wilkenfeld Abra Prentice Wilkin Charitable Trust Dr. Don M. Wilkins Mr. and Mrs. Wayne G. Willems Dr. and Mrs. W. Darrell Willerson, Jr.

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The William Rigg Co. Dr. and Mrs. Bernard T. Williams Mr. and Mrs. Earle C. Williams Mr. and Mrs. J. D. Williams Mr. and Mrs. James A. Williams Ms. Jane Beth Williams Estate of John B. Williams Mr. and Mrs. John R. Williams Mr. and Mrs. Joseph H. Williams Mr. and Mrs. Ray R. Williams, Jr. Williams Companies, Inc. The Paul J. Williams Foundation Ms. Gerry O. Williamson Dr. and Mrs. Hugh J. Williamson Mr. and Mrs. James Williamson, Jr. Mr. and Mrs. Jerry B. Williamson Mr. and Mrs. John D. Williamson, Jr. Ms. Mary J. Williamson Mr. and Mrs. Freddie L. Willie Mr. and Mrs. John C. Willingham Mary V. C. Wills Ms. Helen B. Wils and Mr. Leonard A. Goldstein Mr. and Mrs. H. C. Wilson Mr. and Mrs. Herman T. Wilson, Jr. Mr. and Mrs. James L. Wilson Mr. and Mrs. Thomas H. Wilson Tracy Jo Wilson Ovarian Cancer Foundation Wilson-Cook Medical, Inc. Wings of Life A Fight For a Cure Mr. F. C. Winkelmann, Jr. Mr. and Mrs. M. Paul Winkler, Jr. Dr. J. David Winningham Mrs. Judith Winograd Winokur Family Foundation, Inc. Mr. and Mrs. John D. Winter Mr. and Mrs. Jim P. Wise Mr. and Mrs. William A. Wise Wise Delcotto PLLC Watson W. Wise Foundation William and Marie Wise Family Foundation Dr. and Mrs. James F. Wittmer Mr. and Mrs. Mathew Wolf Wolfe Scott Associates Inc. Mr. and Mrs. Melvyn L. Wolff Cyvia & Melvyn Wolff Family Foundation Mr. and Mrs. H. H. Wommack III Daisy S. Wong and Alden Wong Mr. and Mrs. Don Woo Mr. and Mrs. Brian C. Wood Mr. and Mrs. David Wood Mr. and Mrs. Jackie D. Wood Mr. and Mrs. Jeffrey R. Wood Mr. Larry D. Wood Mr. and Mrs. Leonard W. Wood Ms. Marilee Wood and Mr. Tevis Grinstead Mr. and Mrs. Gene M. Woodfin Ms. Denise S. Woods Mr. and Mrs. Rodney I. Woods Woodson Sixth Grade Class Mr. Tommy Woolam Woolam Gin Mr. R. C. Woolfolk Working Assets World Reach, Inc. Mr. and Mrs. Terry N. Worrell Henry N. Worrest, Ed.D. Mr. and Mrs. Thomas J. Wray

Arthur and Janet Wright Ms. Crystal J. Wright Estate of Theda M. Wright WS Packaging Group, Inc. Mr. and Mrs. Andrew Wu Mr. and Mrs. P. T. Wurster Mr. and Mrs. Michael G. Wyatt Wyatt, Tarrant & Combs, LLP Wyeth Pharmaceuticals Dr. Mary K. Wyss XTO Energy Inc. Mr. and Mrs. Motoshi Yamasaki Dr. Stacy A. Yamasaki Mr. and Mrs. Hurley Yarberry Mr. Fernando A. Yarrito Dr. and Mrs. James R. Yates Estate of Ann Yeager Mr. and Mrs. Kyle Yeates Dr. Ting-Wey Yen You Can Make a Difference Mrs. Diane Young Mr. and Mrs. F. M. Young Mrs. Nolan Young Paul and Susan Torn Young Mr. Phillip D. Young Mr. and Mrs. Steven M. Zager Mr. Henry Zarrow Mr. and Mrs. Stuart Zarrow The Anne and Henry Zarrow Foundation Maxine and Jack Zarrow Family Foundation Mr. Jeffrey C. Zaruba Mr. and Mrs. Jack Zbar Jori Zemel Children’s Bone Cancer Foundation Mr. and Mrs. Steven A. Zenthoefer Zeta Tau Alpha Foundation, Inc. Mrs. Christine Ziebarth Dr. and Mrs. Lane D. Ziegler Mr. and Mrs. Robert C. Ziegler E. Matilda Ziegler Foundation for the Blind, Inc. Mr. Selim Zilkha Mr. and Mrs. Tom Zimmerer Mr. Robert E. Zimmerman Mr. Ronald R. Zimmerman Dr. and Mrs. Stuart O. Zimmerman Mr. and Mrs. Robert L. Zinn Dr. Ralph G. Zinner Dr. and Mrs. Thomas M. Zizic Mr. Eduardo P. Zorrilla Eleanor and Joe Zuber Mr. and Mrs. Joseph F. Zullo Mr. X. Kembo Zunzanyika

Every attempt has been made to ensure the accuracy of this list. If an error has been made, please contact the Development Office at 713-792 -3450.

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–

2 0 0 6

D a t a

A n d e r s o n

C a n c e r

C e n t e r

A n n u a l

R e p o r t

2 0 0 5 â&#x20AC;&#x201C; 2 0 0 6

Source and Use of Revenue

Unaudited Source of Revenue: Net Patient Revenue

FY06 Actual*

$1,760,364,573

Restricted Grants, Contracts and Philanthropy

289,957,497

State Appropriation

158,529,119

Auxiliary Enterprises

22,876,625

Investment and Non-Operating Income

101,368,135

Other Income

20,832,995 $2,353,928,944

Total Use of Revenue: Research**

$341,540,289

Instruction, Academic Support and Public Service

134,678,218

Patient Care

1,194,110,713

Facilities and Depreciation

330,029,490

Institutional Support, Auxiliary and Other

174,067,752

Allocation to Capital Plan

179,502,482

Total

$2,353,928,944

*The format of the financial statement in this annual report reflects the reporting standards of the Annual Financial Report of The University of Texas System.

a point of comparison, total revenue in FY05 was $2,106,884,553. Revenue for FY06 represents an 11.7 percent increase over the prior year. As

**Figure represents total operating expenses only.

Source of Revenue in millions $1,760.4

$20.8 $101.4 $22.9

$158.5

$290.0

Net Patient Revenue

74.8%

Restricted Grants, Contracts and Philanthropy

12.3%

State Appropriation

6.7%

Investment and Non-Operating Income

4.3%

Auxiliary Enterprises

1.0%

Other Income

0.9%

F i n a n c i a l

D a t a

Clinical Profile

FY06 FY05 Actual Actual Admissions

21,221

Patient Days

155,551

153,615

Average Daily Census

432

427

Average Length of Stay

7.3

7.4

Average Number of Operating Beds

521

475

927,414

767,909

7,849,558

7,465,070

412,924

384,882

50,917

50,442

1,081

951

Outpatient Clinic Visits, Treatments and Procedures Pathology/Lab Medicine Procedures Diagnostic Imaging Procedures Surgery Hours Total Active Clinical Protocols

20,728

Institutional Data

15,967

15,234

Faculty

1,367

1,272

Hospital-Based Volunteers

1,611

1,625

Total Employees

Use of Revenue in millions $1,194.1

$134.7

Unsponsored Charity Care $341.5

$330.0 $174.1

M. D. Anderson provided $221.2 million in unsponsored charity care to medically indigent

$179.5

Patient Care

Texans with cancer in FY06.* 50.7%

Research

14.5% *Figure calculated using the formula of the Texas Legislature.

Facilities and Depreciation

14.0%

Allocation to Capital Plan

7.6%

Institutional Support, Auxiliary and Other

7.4%

Instruction, Academic Support and Public Service

5.7% 73

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155,551

Hospital Patient Days 153,615 150,915 144,906

134,926

2004

2003

2002

2005

2006

Gross Revenue by Payor Classification in millions $1,983.5

927,414 $98.3

Outpatient Clinic Visits, Treatments and Procedures

$112.2

767,909

$1,002.3

605,848 537,822 471,728

2002

2003

2004

2005

2006

$169.4

Managed Care

58.9%

Medicare

29.8%

Other

5.1%

Indigent

3.3%

Medicaid

2.9%

F i n a n c i a l

D a t a

$134.8

Total Philanthropic Gift Support by Type FY06

in millions

CASH GIFTS

AMOUNT

Corporations

$12,031,929

Foundations

21,036,221

Individuals

25,870,894

Organizations

3,213,419

Trusts and Estates

3,386,629

SUBTOTAL

Comparison of Total Dollar Gift Amount to FY Fundraising Goals

$111.1

$103.5 $88.0 $84.0

$65,539,092

$87.9

$73.0

PLEDGE GIFTS* Corporations

$3,572,392

Foundations

11,094,087

Individuals Organizations Trusts and Estates SUBTOTAL

$80.0

2006

38,514,539

2003

1,903,366

Fundraising Goal

$68,456,112

FY06 Total Philanthropic Gift Support by Purpose in millions $81.0

GIFTS-IN-KIND Corporations

$805,757

Foundations

2 35,074 $5.4

Organizations SUBTOTAL

180 $841,013

TOTAL AMOUNT OF GIFTS *Pledge gifts are not reported here at Net Present Value. Discounted value of Planned Gifts is $9,629,714.17

Total Dollar Amount of Gifts

13,371,728

Individuals

2004

2005

$134,836,217

$36.9 $11.5

Research*

60%

Capital Facilities

27%

Annual/Unrestricted/Undesignated**

Education/Prevention/Patient Care

*Donor-targeted gifts to research conducted in all mission areas. **These dollars fund institutional peer-reviewed research. 75

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Sources of Research Expenditures FY06 FY05 Actual Actual

External Funding for Research $182,028,411

$160,953,853

Private Industry Grants and Contracts

28,020,431

26,766,196

Philanthropy and Foundations

49,678,965

43,062,200

$259,727,807

$230,782,249

Federal Grants and Contracts

Total External Funding

Internal Funding for Research $13,825,123

$15,565,503

8,470,040

5,094,852

Hospital Operating Margin

107,857,201

84,111,416

Institutional Grants

19,799,540

6,424,659

$149,951,904

$111,196,430

$409,679,711

$341,978,679

State Appropriated General Revenue Tobacco Settlement Receipts

Total Internal Funding

Total Research Expenditures*

Figure includes operating expenses, indirect costs and capital asset purchases.

Education Profile FY06 FY05 Actual Actual

958

979

1,365

1,421

Observers, Visitors and Special Programs

607

481

Nursing Students/Rotations

836

778

Student Programs

514

396

157

4,366

4,212

Clinical Residents and Fellows* Research Fellows

School of Health Science Programs*

Total Number of Trainees

*In 2006, numbers are reported for July-June academic year, while 2005 numbers are for September-August fiscal year.