MDI Biological Laboratory by MDI Biological Laboratory

Breaking

Through 2014 Annual Report to Our Donors

Michael Westphal is a champion marathoner. Ever since his diagnosis nine years ago, Michael has been running a marathon against the debilitating condition known as Parkinson’s disease. It’s a long distance race, and he never gets any time off. But the qualities that make him a champion — perseverance, endurance, and courage — allow him to break through the limits imposed by his disease every single day. The stakes couldn’t be higher. Because Michael isn’t just running for his own life. He is running for all of us.

This report is dedicated to the donors, patients and scientists who believe and make breakthroughs possible.

e CHAIRMAn’s MESSAGE

Champions of Medical Breakthroughs Table of Contents Not all champions are athletes. In fact, Merriam-Webster

Rather, each new insight leads to another and another, until

defines the word “champion” without even mentioning the

we finally achieve the breakthrough that the MDI Biological

CELEBRATING CHAMPIONS

concept of sports. A champion, the dictionary says, is a

Lab seeks—to revolutionize human medicine by slowing down

“warrior, fighter,” or “a militant advocate or defender.”

the aging process, and by enabling organs and body parts that

GOING THE DISTANCE AGAINST PARKINSON’s

And by these definitions, we encounter champions every

have been damaged to regenerate.

BENEFITING FROM SCIENTIFIC BREAKTHROUGHS

What makes all this possible? You, our donors.

SECURING OUR FUTURE

2014 FINANCIAL Highlights

day through the work of the MDI Biological Laboratory. There are patients, like Michael Westphal and Alan Fidler, whose stories you will find in this report. They have both

Without you, the MDI Biological Laboratory couldn’t support

repeatedly shown the courage and determination of

the scientific experts and technical resources that make

champions, fighting the challenges of Parkinson’s and

our transformative research possible. We couldn’t pay for

heart disease. Their commitment to breaking through the

salaries, research supplies, or equipment.

16-25

2014 YEAR-IN-REVIEW

debilitating symptoms of their diseases in order to live fulfilling lives—to be there for their families—is inspiring.

Because of you, we are on the brink of making revolutionary

(Michael actually is also a champion athlete—a marathoner—

improvements to human health. You are our champions of

but more on that in the following pages.)

generosity, belief, and dedication. Thank you.

Then there are the scientists on our faculty, like Aric Rogers and Voot Yin, who come to work each day to fight the ravaging consequences of diseases like Parkinson’s and heart disease. It requires the toughness and perseverance of champions to return to the bench each day to push the research a little bit farther. Contrary to the popular image, progress in science is rarely marked by a single, world-changing, “eureka” moment.

C ELEB RAT I N G CHA M P IO N S

Peter J. Allen, M.D. Chairman, Board of Trustees

Breaking Through \ 2014 Annual Report \

“ I’d sleep much better knowing that the smile on my little granddaughter’s face will never be swept away by the consequences of Parkinson’s.”

Michael Westphal

Going the Distance Against Parkinson’s Disease

Michael is a born athlete. All through high school and college, he ran competitively—track and cross country—and he was known throughout his state of Maine as one of the best. After college, he continued to compete in long distance road races. He ran 14 marathons. And then he put competitive running aside for twenty years to focus on managing a growing business and raising two sons with his wife. Unexpected diagnosis Michael’s vigorous physical condition made the bad news especially hard to believe. Nine years ago, at age 49, he was diagnosed with Parkinson’s disease. Parkinson’s is a degenerative, neurological disorder, affecting one million Americans and over four million individuals worldwide. The disease is age-related, striking most people at 50 or older. Symptoms include tremors, rigidity of the limbs and torso, slow movement or an inability to move, and impaired coordination. And they worsen slowly over time. “My first reaction? I don’t think I believed it,” Michael remembers. My biggest fear was that in ten years, I’d be disabled, in a wheelchair. I decided early on that I wasn’t going to lie down and take it. I’m a positive person. I didn’t want people to feel sorry for me.” Michael took medications to control his symptoms to the extent possible, and spent the next seven years concentrating on his work. He and his crew (which includes both his sons, now ages 30 and 32) built three houses, and completed a number of other big projects. “My goal was to work as long as I could to save money for the time when I couldn’t work anymore.” Determined to do what he always loved Then, last year, he decided to take up running again. “I wanted to get more out of life than just working all the time,” he says. He wasn’t sure how he’d perform. “I knew I could run short distances, but I was surprised that I had the endurance to run long distances.”

G O I N G T HE D ISTA NCE

Michael was thrilled to find that he still has what it takes to exercise hard. But there’s been a terrific bonus: he believes that running has improved his condition. “I have almost no symptoms and feel great when I’m running,” he says. “Even during the rest of the day, I feel much more normal than I did before.” In fact, he felt so good that he decided to undertake a marathon. He began training—running up to 55 miles a week—for the 2015 “The Great Run,” held each June on Great Cranberry Island. And he did it to raise funds for The Michael J. Fox Foundation for Parkinson’s Research. “Not everybody can run a marathon, but everybody should do what they can to further the cause they believe in. That’s what I’m doing.” Michael raised over $36,000 and completed the race in 3:32:56—a time that qualifies him to run the 2016 Boston Marathon. With the recent birth of his granddaughter, Maeve Grace, Michael has more motivation than ever for raising funds for Parkinson’s research. About 15 percent of those with the disorder have a family history of Parkinson’s. Four of Michael’s close relatives—including his sister—have battled the disease. “I’d sleep much better knowing that the smile on my little granddaughter’s face will never be swept away by the consequences of Parkinson’s,” he says. “That’s why I’m persevering to raise money.”

Breaking Through \ 2014 Annual Report \

The Rogers Lab fights against Parkinson’s and other diseases Meanwhile, across the bay at the MDI Biological Laboratory, Aric Rogers heads up a lab that is exploring why growing older causes certain individuals to succumb to degenerative diseases associated with aging— including Parkinson’s disease. Parkinson’s, Alzheimer’s, and Huntington’s disease are all “diseases of aging,” says Aric. “People live healthy for years—even if they have a genetic predisposition to one of these diseases. And then, late in life, something goes wrong with the genetic machinery that is tasked with keeping the cells clean and uncluttered. As a result, the cells of these individuals develop a dangerous build up of proteins—a different protein for each of these diseases —and lose their ability to function properly.” And the disease takes over.

It may seem surprising to study a worm to learn about human aging and disease—but it’s actually a perfect choice. It shares about half its genes with humans—including the mechanisms that are associated with keeping the cells clean and tidy. They live an entire lifetime in a matter of weeks— so the effects of aging on their cells can be studied quickly and easily. And they reproduce fast—each worm can make up to 300 worms in just a few days—so they are inexpensive and easily available. The second trailblazing feature of Aric’s approach: don’t focus on eliminating the protein buildup in the cells. Instead concentrate on repairing the malfunctioning cell machinery so that it regains its ability to stop the protein buildup before it occurs. This will keep the cells healthy, longer—and help prevent the onset of all of these degenerative diseases of aging.

Michael Westphal owns his own carpentry business on Great Cranberry Island, off the coast of Mount Desert Island. Aric Rogers is a research scientist and assistant professor of regenerative biology at the MDI Biological Laboratory. They have something profound in common: they are both doing everything they can to fight the debilitating degenerative condition known as Parkinson’s disease, each in his own way.

Aric’s team is examining why—and searching for ways to prevent or slow down the failure of this “housekeeping” machinery that marks the onset of these diseases. Their approach to the problem is unusual in a couple of ways. An innovative and expedient approach First, they have chosen the tiny worm, C. elegans, as their research model, rather than more commonly used lab mice and rats.

G O I N G T HE D ISTA NCE

Based on their research so far, Aric and his colleagues believe that certain lifestyle changes have potential for strengthening cells that have been damaged in this way. They’ve seen that when cells are exposed to the temporary stress that comes with dietary restriction, exercise, or temperature change, for example, they respond by hunkering down to protect themselves—and in the process, they regain some of their efficiency. That’s why Aric wasn’t surprised to hear that Michael’s Parkinson’s symptoms have diminished with his increased physical training.”

Aric’s team is also exploring a variety of therapeutic compounds to do the job more effectively. “We’re working to identify targets for new drugs that will reduce the effects of aging—including reducing the incidence of disease. That’s the ultimate hope.”

AT THE BENCH

PeRfect Models With a lifespan of just three weeks, C.elegans enables us to gain valuable insight into age-related diseases in a matter of days instead of years. Here, the tiny worms’ unique transparency allows scientists to study the effects of Parkinson’s disease with the simple aid of a microscope.

Michael Westphal, his family, and millions of others who deal with the pain, fear, and loss of Parkinson’s and other degenerative diseases, are waiting.

Breaking Through \ 2014 Annual Report \

“Each time I came to a critical juncture, it seemed that a new treatment became available. Science has always been there for me.”

Alan Fidler

Benefiting from Scientific Breakthroughs

Alan Fidler has battled heart disease for 35 years (and counting). He has undergone seven major surgeries and any number of less significant procedures and treatments. It began in 1980. Alan was 36 and healthy, working long days to launch a high-powered career as an engineer and executive at Polaroid. He had a wife and three young boys. Out of the blue, he had a heart attack. “It wasn’t a terribly bad one—it was what they call a warning heart attack,” he recalls. “They did all the appropriate testing and risk analyses. I didn’t fit the profile—no high cholesterol or blood pressure, no family history of heart disease, nothing. I chalked it up to bad luck, started exercising more, went on the appropriate medications, and got on with my life.” Neither he nor his doctors expected anything more to happen. But three years later, they were all proved wrong. Alan suffered a massive heart attack. “I shouldn’t have lived through that one. I was closer to dead than alive.” Emergency surgery revealed such extensive damage that the heart muscle could no longer beat symmetrically. Surgeons removed a significant portion of his heart and performed a quadruple bypass—an incredibly complex and dangerous surgery—and hoped for the best. “I knew it was about as serious as it could get,” says Alan. “I remember saying goodbye to my wife and children.” He kept the details of his struggle to himself, knowing that revealing his condition would sabotage his chances for professional success. “I was not going to let this thing define me.” He continued climbing Polaroid’s corporate ladder and raising his family.

BEN EF I T I N G FROM SCIEN T IFIC BREA KT HROU GHS

But it wasn’t easy. It took a toll on Alan. Because the pumping ability of his heart was greatly reduced, he had to limit and monitor his activities. He watched his diet and took a lot of medications. He always wore a shirt in the pool to cover the frightening scar on his chest, and long pants to cover the scars on his legs where they took veins to use for his bypass surgery. Perhaps even worse was the toll on his wife, who lost any semblance of security about the future, knowing that she had “a time bomb sleeping next to her each night.” The following decades brought five more life-threatening surgeries for bypass repairs, electronic defibrillator implantation and subsequent repairs, surgical ablation, and defibrillator replacement. Alan is thankful that each procedure extended his life—but he’s all too aware that they are just Band-aids—not cures—for his heart disease. “Heart damage is irrevocable—it can’t be fixed. For someone like me, there is nothing more that can be done,” says Alan.

But what if there were a way to stimulate the human heart to regrow or repair the damage caused by a heart attack?

Breaking Through \ 2014 Annual Report \

The Yin lab: going way beyond the band-aid Voot Yin, research scientist and assistant professor of regenerative biology at the MDI Biological Laboratory, and his colleagues are certain it’s possible—because that ability has already been achieved in a variety of animals, over millions of years of evolution. The zebrafish, for example, is a champion of regeneration. Cut off part of its tail, brain, spinal cord, pancreas—and yes, even its heart—and it will completely regenerate bone, nerves, muscle cells, and blood vessels, fully restoring both form and function.

Michael Westphal owns his own carpentry business on Great Cranberry Island, off the coast of Mount Desert Island. Aric Rogers is a research scientist and assistant professor of regenerative biology at the Mount Desert Island Biological Laboratory. They have something profound in common: they are both doing everything they can to fight the debilitating degenerative condition known as Parkinson’s disease, each in his own way.

Particularly for someone like Alan. Voot believes that if drugs that stimulate heart regeneration were available at the time of his first heart attack, “Alan’s life may have been completely different. He may never have experienced reduced heart function and his quality of life could have Voot Yin, research scientist and assistant been improved.” professor of regenerative biology, gives a simple

explanation of a heart attack: “The arteries that provide oxygen to the heart muscle become clogged and the muscle, deprived of oxygen, begins to die. The major problem is that the human heart doesn’t create new heart muscle to replace the damaged area.” And in the U.S. alone—someone dies from a heart-disease related event every single minute.

“Why come up with the next great solution from scratch when the next great solution is already here?” asks Voot. He and his colleagues decided to study how zebrafish regenerate tissue, looking for ways to activate this process in humans. Since humans share 70 percent of their genes with zebrafish—including those the fish use for regeneration—it promised to be an expedient line of inquiry. In 2012, when Voot and his colleagues identified a naturally occurring chemical that stimulates the genetic machinery of zebrafish to regenerate tissues two or three times faster, his team began exploring whether the substance might encourage regeneration in humans. 10

BEN EF I T I N G FROM SCIEN T IFIC BREA KT HROU GHS

Subsequent research and testing have shown that this substance—potentially the basis for a new therapeutic drug—is stunningly effective at kickstarting the regrowth process—not only in zebrafish, but also in mammals who (like humans) don’t naturally have the ability to regenerate damaged tissue. When this drug was administered for only four weeks to mice who suffered heart damage—just like the damage humans sustain from a heart attack—these animals showed a 200 percent improvement in heart function and a 50 percent reduction in scar tissue. The implications for human heart health are profound.

Changing the future For now, the testing of this drug will continue. Studies on adult pigs will follow the current mouse studies. And if those are successful, the researchers will move into human drug trials. If the drug works in humans, Voot believes that—with adequate funding for this research—it could be available for heart attack patients within ten years.

Alan is alive today because of the great leaps in medical science over the last 40 years. “Each time I came to a critical juncture, it seemed that a new treatment became available,” he says. “Science has always been there for me.” But the next great innovation may be right around the corner, thanks to Voot’s team and their zebrafish. “Alan’s a great example of a person who has benefited by advances in scientific research and technological innovation,” says Voot. “We’re trying to push both of these frontiers so that we can help the future Alan Fidlers of the world.

AT THE BENCH

HEART

REGENERATion Research scientist Voot Yin is championing what could be the next great solution for heart disease. Here, brightly colored areas depict the formation of naturally regenerating heart cells and blood vessels in a damaged zebrafish heart. Based on results with this model, Yin and his team are now exploring the ability of a potential new drug to stimulate similar repair in mammals.

Breaking Through \ 2014 Annual Report \

Securing the Future of Scientific DisCovery The MDI Biological Laboratoryâ&#x20AC;&#x2122;s Plan for Sustainability Working with our Board of Trustees, we have developed an

recruit research faculty, and create a drug discovery and development

new research opportunities and build new partnerships. Building on

goals: grow our research faculty, build industry and other strategic

significantly expand our educational programs by constructing a

to develop state, regional, and national partnerships to enhance our

sq. ft. training laboratory into research space for the recruitment of

a partnership agreement with the Australian Regenerative Medicine

facility to improve human health. This award will allow us to

our reputation for collaboration and open exploration, we continue

With your help, we will continue to be

6,500 sq. ft. training laboratory and converting our existing 1,700

research and educational capacity. For example, we recently signed

bolder, dream bigger and act as a catalyst

two additional faculty members.

Institute at Monash University in Melbourne, Australia to develop

faculty. Doing so in a careful, strategic way will allow us to preserve

This award came on the heels of a five-year, $13 million Center of

explore the formation of a drug discovery consortium to identify new

strengths, achieve a critical mass of research faculty, and establish

Network of Biomedical Research Excellence grant from the National

aggressive five-year, $15 million strategic plan with three essential partnerships, and expand our education program.

To gain recognition as a world-class institution and leader in

regenerative biology and medicine, we must continue to grow our the unique characteristics of the Institution, capitalize on our long-term financial stability.

The involvement of our donors and our community in our work is a hallmark of our recent success and remains critical to our future.

One obstacle to growing our faculty is the lack of adequate laboratory space. Recently, Maine voters approved ballot Question 5, providing $3 million to increase biotechnology workforce training, retain and

S E C U RI N G O U R F U T URE

new scientific, educational and biotech business connections and to

Biomedical Research Excellence grant and an $18 million IDeA

pharmaceutical treatments for human disease.

Institutes of Health. These highly competitive NIH grants are designed

Maintaining our momentum

Laboratory to be more competitive and mandate a certain level of

a hallmark of our recent success and remains critical to our future.

specifically to assist smaller institutions like the MDI Biological

The involvement of our donors and our community in our work is

growth and expansion.

We continually look for meaningful ways to engage and expand our

Achieving the strategic goal of recruiting three new faculty members

a former student, or a member of the community who is interested

size of 15-18 research laboratories with a total staff of 150 over the

future of regenerative medicine and the MDI Biological Laboratory

one day touch the life of someone you know.

Maybe even you. Sincerely,

sphere of supporters. Whether you are a trustee, a long-time donor,

by 2018 will ensure the Institution is on track to reach our optimum

in learning more about our research, you can have an impact on the

next decade.

by helping us spread the word about our important work.

Building strategic partnerships

MDI Biological Laboratory has been a lean, agile, innovative

With new financial support comes the responsibility to develop

for life-changing discoveries that may

Kevin Strange, Ph.D. President

institution for 117 years, and weâ&#x20AC;&#x2122;re not about to stop now.

Breaking Through \ 2014 Annual Report \

Operating Expenses 2014

(excluding depreciation)

Statement of Financial Position

esearch Programs & • RCore Services

33%

Subawards • Rtoesearch Other Institutions

21%

acilities, Interest & • FMiscellaneous eneral & Program • GAdministration Development & • Public Affairs

13%

Research Training & • Education Programs

Statement of Activities

Year ended December 31, 2014 (with summarized financial information for the year ended December 31, 2013) 2014

December 31, 2014 (with comparative financial information as of December 31, 2013)

17%

Funding Sources 2014

2013

Cash & Cash Equivalents

3,210,737

1,959,290

Certificates of Deposit

6,335,219

6,033,029

Receivables - Grants & Programs

834,953

936,863

Receivables - Contributions & Pledges

312,805

176,322

Investments

4,747,115

4,031,973

Other Assets

146,572

160,811

Land, Buildings & Equipment (net)

14,020,370

14,025,397

Unrestricted Temporarily Permanently Total Total Restricted Restricted Operating Support & Revenue Government Grants & Contracts 6,999,897 6,999,897 6,243,412 Contributions & Private Grants 690,188 1,375,800 240,740 2,306,728 1,441,833 Fees for Programs & Services 1,695,526 1,695,526 1,578,016 Investment Return Utilized 150,687 150,687 124,134 Interest & Other Income 37,069 67,165 104,234 130,350 Assets Released to Support Operations 611,534 (611,534) 0 0 Total Operating Support & Revenue 10,184,901 831,431 240,740 11,257,072 9,517,745

Total Assets

29,607,771

27,323,685

Expenses

2014

2013

Accounts Payable & Accrued Expenses

557,069

506,341

Accrued Indirect Cost Adjustment

588,691

296,157

Revenues & Grants Received in Advance

246,914

233,287

Bonds Payable

4,525,000

4,630,000

Total Liabilities

5,917,674

5,665,785

11,904,841

11,584,416

Temporarily Restricted

7,351,259

5,880,227

Permanently Restricted

4,433,997

4,193,257

Total Net Assets

23,690,097

21,657,900

Total Liabilities & Net Assets

29,607,771

27,323,685

LIABILITIES & NET ASSETS

•

F oundation & Other Grants

nrestricted • UContributions

• Restricted Funds Released

117

20%

7% 5% 3%

Net Assets Unrestricted

rogram Fees & • POther Income ederal Funding for • FResearch Subawards

48%

OPERATING ACTIVITIES

2014

ASSETS

Liabilities

ederal Grants & • FContracts

2013

Research Programs & Core Services Research Training & Education Programs Research Subawards Facilities & Dining Hall Development & Public Affairs General Administration Interest & Miscellaneous Expenses Depreciation & Amortization Total Operating Expenses Change in Net Assets from Operating Activities

3,243,468 746,968 2,124,748 961,020 770,637 1,605,258 255,985 1,121,059 10,829,143 (644,242)

3,243,468 746,968 2,124,748 961,020 770,637 1,605,258 255,985 1,121,059 0 0 10,829,143 831,431 240,740 427,929

NON-OPERATING ACTIVITIES Grants & Contributions for Capital Purposes Proceeds from the Sale of Assets Investment Return, Net of Amount Used Change in Net Assets from Non-Operating Activities Total Change in Net Assets Net Assets, Beginning of Year Net Assets, End of Year

962,173 962,173 100,543 2,500 322,752 325,252 0 (6) 316,849 316,843 594,170 964,667 639,601 0 1,604,268 694,713 320,425 1,471,032 240,740 2,032,197 (400,851) 11,584,416 5,880,227 4,193,257 21,657,900 22,058,751 11,904,841 7,351,259 4,433,997 23,690,097 21,657,900

The financial statements of the MDI Biological Laboratory for the fiscal year ending December 31, 2014 were audited by Horton, McFarland, and Veysey, LLC. They are available on our website and upon request.

2,961,155 642,009 2,574,540 1,019,659 646,869 1,404,139 267,069 1,097,869 10,613,309 (1,095,564)

F I NA N C I A L H IGHLIGH T S

Breaking Through \ 2014 Annual Report \

Year in review

2014

Thanks to you, the MDI Biological Laboratory celebrated a number of important achievements in 2014. We are pleased to share highlights of all that your support makes possible.

IDeA Network of Biomedical Research Excellence (INBRE) Senator Susan Collins joined academic and scientific leaders from across the state to join Drs. Patricia Hand and Kevin Strange in celebrating receipt of an $18.4 million grant from the National Institutes of Health to strengthen biomedical research and workforce training in Maine. The grant will continue to support the Maine INBRE program for another five years, providing hands on research training to more than 800 Maine undergraduate students through summer research fellowships, academic year short courses, and research assistantships throughout the state. “The INBRE program is a powerful instrument for bringing educational and scientific institutions from Fort Kent to South Portland together to help our state be more competitive nationally,” Collins noted. “For years I have advocated for more collaboration between Maine’s research and development labs and Maine’s students, and the MDI Biological Laboratory has led the way.”

YE A R IN REV IE W + D O N O RS

Our Donors

The MDI Biological Laboratory is extremely grateful to all the donors who generously support our work. This list represents contributions made from January 1 to December 31, 2014. Every effort has been made to ensure the accuracy of this list. Our sincere apologies if any omissions or errors have occurred. $100,000 and over Anonymous Dr. and Mrs. James B. Claiborne Cotswold Foundation Trust Mrs. Shelby Cullom Davis° Mr. and Mrs. I. Wistar Morris III $50,000 to $99,999 Ellison Medical Foundation $25,000 to $49,999 Cserr Family Jewish Communal Fund Mr. Alan W. Kornberg and Mr. Harold J. Koda Long Cove Foundation, Inc. Mr. and Mrs. Alan B. Miller Salisbury Cove Research Fund of the Maine Community Foundation Alex C. Walker Foundation $10,000 to $24,999 Dr. Edward J. Benz, Jr., and Dr. Margaret A. Vettese Phoebe C. Boyer* and Todd R. Snyder Floy and Spencer Ervin Mr. and Mrs. Frank L. Hohmann III The Manzanar Project Dr. Josephine A. Sollano Illiana van Meeteren and Terence C. Boylan* $5,000 to $9,999 Anonymous (2) Peter J. Allen, M.D., and Ms. Sarah M. Hodder Blum Halsey Scholars Fund of the Maine Community Foundation Mary M. Brandes* Davis Conservation Foundation Susan K. Fellner, M.D.

Mr. and Mrs. Edward Hoffman Ellie and Victor Kelmenson Lewis B. Kinter, Ph.D.,* and Terry Timberlake-Kinter T.H. Maren/ S.K. Fellner Fund of the Triangle Community Foundation Steen° and Janet Meryweather Sharpe Family Foundation, requested by Henry and Peggy Sharpe Mr. and Mrs. Robert Sillerman Ms. Kate Spokes* $2,500 to $4,999 Dr. and Mrs. James L. Boyer John W. Bristol Fund of the Maine Community Foundation Mr. and Mrs. William G. Foulke, Jr. Ms. Alexandra Goelet Mr. and Mrs. Melville T. Hodder Mr. and Mrs. Stephen B. Homer Anne* and Robert Lehmann Nature Conservancy, Maine Chapter Nancy and George Putnam John R. and Barbara Robinson The David Rockefeller Fund Elizabeth and Bruce A. Stanton The Widgeon Point Charitable Foundation $1,000 to $2,499 Jane* and Abass Alavi Dr. Thomas A. Boyd* and Mrs. Judith Boyd Florence V. Burden Foundation Mr. and Mrs. Ordway P. Burden Dr. and Mrs. Thomas R. Cech Cheryl M. Coffin, M.D., and Ralph E. Topham Dr. John M. Cohen Chuck* and Megan Dinsmore Dr. Dianna and Mr. Benjamin R. Emory Sherrie S. Epstein Timur Galen and Linda Genereux Edward and Verna Gerbic Family Foundation Ms. Mary Cox Golden Evangeline R. Haarlow Mr. and Mrs. Richard C. Habermann Mr. and Mrs. James B. Harrison Mr. and Mrs. Orton P. Jackson, Jr. Emy Leeser

Mr. and Mrs. David Loo Dr. Betty M. Massie Mr. Timothy McAllister and Ms. Beth Lehman David and Mimi Miller Phyllis R. Monroe, M.D., and David S. Cannom, M.D. Warren Motley and Cynthia Saltzman Elizabeth R. Myers, Ph.D.,* and Evan Vosburgh, M.D.* Ocean Ledges Fund of the Maine Community Foundation Clive Palfrey* Margie Patlak and Frank Chudnow Donna and Stephen Pinto Barbara Rappaport Mr. Allyn Seymour Ms. Sarah A. Sharpe Sharpe Family Foundation, requested by Douglas and Ann Sharpe Sharpe Family Foundation, requested by Julie & Henry Sharpe III Frank Sheldon, M.D., C.M. Christopher Sighinolfi* and Devon Chatley Patricio Silva, M.D.,* and Vjera Bakovic, M.D. Dr. Neil D. Smith* and Ms. Mary Ryan Mrs. Clare Stone Mr. Don Stott Mrs. Sohny Kang Strong Mr. and Mrs. William N. Thorndike Mr. and Mrs. Christiaan van Heerden $500 to $999 Anonymous (2) Atwater Kent Foundation, Inc. Ms. Christine Boyer and Mr. Anton Linder Dr. Joseph and Mrs. Pamela Catanzano Mr. and Mrs. Douglas Childs Lura* and Bill Clark Dan and Kate Coit Dr.* and Mrs.* David Colley Rod and Verena Cushman Ms. Kathie R. Florsheim Peggy Forster* Mr. Gary E. Frashier Brian and Dawn Gonick

Mrs. Caroline Huber Allan and Joan Kleinman Dr. and Mrs. Julius R. Krevans Alice and Michael Lilly Mr. and Mrs. Lennart S. Lindegren Bram* and Lori Lutton Allen H. Mackenzie, M.D.* Sara W. Pierce Ms. Mary Ratner and Mr. James Mroch Mr. and Mrs. Michael S. Rockefeller Dr. J. Denry Sato and Ms. Christine Chapline Edith N. Schafer Brad and Lynn Thompson Samantha A. Vitagliano, D.M.D. $250 to $499 Anonymous (2) Acadia Institute of Oceanography Judith T. and Robert P. Adelman George P. Bayliss, M.D. Anatole and Fani Besarab Dr. and Mrs. Mordecai P. Blaustein Jerilyn Mitchell Bowers Yellow and Christina Breen Sarah L. Clark Karan Cushman Ms. Elizabeth Cutler Mr. Andrew Davis David and Kay Dawson Mr. and Mrs. James Donovan Drs. Michael* and Paula* Duffy Jonathan A. Epstein* and Margaret A. Myers* Richard A. Eustis David H. and Jean Evans Dr.* and Mrs. Jay P. Farber Mr. and Mrs. Nathaniel R. Fenton Dr. Michael Field° and Dr. Linda Seidel Wendy Gamble and Anthony Kuehn Mr. Jonathan Garber* and Ms. Bonnie Fought Robert Gossart and Judith Burger-Gossart Mrs. L. Gordon Hamersley, Jr. Samuel M. Hamill, Jr. Dr. Patricia Hand and Mr. Victor Hand Ms. Nancy G. Harris Mr. John A. Hays*

Becky and Doug Heden Mrs. Deborah Hendrie Carolyn and Dave Hollenbeck Betsey Holtzmann Drs. Robert* and Sondra Howe Daniel Kniaz, M.D.* Christine Rogers Kurland, M.D., FACR Gerrish H. Milliken Foundation Theresa and Charles Mitchell Diane and David Modesett Mr. and Mrs. Donal B. Murphy Charles Nicholson Dr.* and Mrs. Robert Patterson Bob and Susan Peck William J. Penhallurick, M.D. and Debra A. Chase, Ph.D. Mrs. Eleanor R. Peterson Mr. and Mrs. R. Anderson Pew Dan° and Polly Pierce Mr. Daniel Pileggi and Ms. Bronwyn W. Kortge Jerome G. Porush, M.D. Dan and Nancy Poteet Robert and Joyce Preston Nathaniel Putnam and Virginia Kozak Putnam Mr. and Mrs. Ivan Rasmussen James A. Rawls, M.D.* Elizabeth S. Roberts Drs. Pam and Stephen Ross Mr. William B. Ruger, Jr. Mr. Jack Russell and Ms. Sandy Wilcox Dr. Jurgen Schnermann and Dr. Josie Briggs Mr. Christopher Scholz and Ms. Inez Elskop Dr. and Mrs. Dennis L. Shubert John G. T. Slater, Jr. Tom and Judy Sproule Ray and Katharine* Stanford Stephen Sullivan and Mia Bongiovanni Mr. and Mrs.* Andrew F. Trotter Peggy Crowell Walklet Mr. and Mrs. Bradford Wellman Mr. and Mrs. David Wheatland Michael and Sandra Widlitz Jacquelyn and Robert* Wondergem Richard and Linda Wright

$100 to $249 Anonymous (3) Mary Beth Rushton Adams* and Daniel R. Adams Peter Aronson and Marie Landry Vicky and Dick Bergman Mr. and Mrs. Jason Bernhard Harold and Lisa Bertrand Drs. Christopher Bever, Jr., and Patricia A. Thomas Mr. and Mrs. James C. Bostwick Douglas and Joan Brazinski Stewart Brecher Architects Robert S. Brown, M.D. Samuel F. Burgess Brian and Sarah Cole Mr. and Mrs. Tristram Colket, Jr. Drs. Gary* and Abigail Conrad Frank P. Conte, Ph.D. Coosaw Creek Book Club Elizabeth E. H. and Barclay F. Corbus John and Marcie Correa Mr. Richard B. Cough Mr. and Mrs. Todd Crow Anne P. R. Dean Drs. Megan N. Dethier* and David Duggins Dr. Patsy Dickinson and Mr. Greg Anderson Kelly S. and George A. Dickson III Michael and Jan Duffey Mr. and Mrs. Skip Everitt David and Judith Fischer Kevin Foskett and Hilary Martin Dr. and Mrs. Richard R. Fox Deborah S. Friedman, D.V.M. Dr. and Mrs. Bradley Gale Rev. and Mrs. Allen R. German Dr. Mary E. Gerritsen Dr.* and Mrs. Samuel D. Goos Mrs. Lewis H. Gordon, Jr. Nina and Jonathan Gormley Ms. Tatiana Gott* Greenstein Family George S. Grove Joseph S. Handler, M.D. Michael and Sheila Humphreys Mrs. Paula M.S. Ingalls Joel Karp Breaking Through \ 2014 Annual Report \

Dr. Steven K. Katona and Ms. Susan L. Lerner Mr. and Mrs. James M. Kellogg Erica Kirsners and Adam Silk Mr. and Mrs. Lawless Jennie C. Leslie Mr. Irwin List Dr. and Mrs. Ralph Longsworth Karen and Bill Lyons Ken Mackie Drs. Joan F. Mansfield and Frederick L. Mansfield Maude and John March, Jr. Dr. Mary-Vesta Marston-Scott Henrietta Martindale Ms. Anne Mazlish Nancy W. McKelvy Ms. Liz McMullan and Mr. Kaveh Haghkerdar Jean and Conrad Minnich Alvin and Margaret Morris Bob and Shari Morris Mark and Georgia Munsell Lynn and John Orav Drs. Beverly and Kenneth Paigen Carol and Bob Pepler Judith S. Perkins Marnie and Asa Phillips Kenneth and Alexis Poss Charles and Patricia Pugh Ellie W. Ramsey Mr. and Mrs. Dean Read Mr. and Mrs. John P. Reeves David Rieck* and Jacy Myers* Dr. and Mrs. John R. Riordan Hilda K. Roderick Elizabeth Rodini and Charlie Rudin Shari and Derry Roopenian Dr. Caroline E. Rubinstein and Mr. Phillip Winegar Drs. Jean M. and Joseph W. Sanger Dr. and Mrs. M. James Scherbenske Marianne Schuelein, M.D.* Arthur Shevchenko Nancy and Mark Shumeyko Mr. Richard Staron Jackie Stokes Dr. and Mrs. Peter F. Straub Dick TenEyck and Marie Taylor 18

YE A R IN REV IE W + D O N O RS

Prof.* and Mrs. Klaus W. Thurau Dr*. and Mrs. Jerry Wacks Mr. and Mrs. Charles Wiggins William and Marilyn Wilson Margot A. Woolley and Gerard F. Vasisko Torj and Kurt Wray $1 to $99 Anonymous (7) Dr. Richard H. Adamson* Seth Alper and Roberta Isberg Dr. Thorsten Althoff* Toby and Richard Anthony Drs. Rita S. Axelrod and Howard J. Naidech Elizabeth L. Barnard Dr. Siribhinya Benyajati Joyce Webster Billings Mr. and Mrs. Robert C. Bloomberg Mr. and Mrs. Michael Blythe Ms. Pat Boyce Dr. and Mrs. William C. Bromley Peter Burt Mr.* and Mrs. Barry M. Butcher Ms. Jean C. Camuso and Mr. Eric R. Brown Mr. and Mrs. Fred Carney William H. Cliff, Ph.D.* Mr. and Mrs. James L. Clunan Susan E. Cochran and David S. Larkin Dr. and Mrs. Martin A. Connaughton Elena C.A. Correa* Dr.* and Mrs. Richard Crawford Dr. and Mrs. Gary Cutting Drs. Guissou Dabiri and John Emery Dr. and Mrs. William H. Dantzler Hugo R. de Jonge Mr. Steven DePaul and Ms. Elizabeth Rendeiro Dr. Jane Disney Arthur and Marjorie Dole Mr. and Mrs. John F. Doyle Dr. Tom W. Ecay Edward J. Fine, M.D. Mr.* and Mrs. Nicholas Franki Mr. Michael Fraser Mr. John Geddie Dr. and Mrs. Yale E. Goldman

Mrs. Leon Goldstein GoodSearch Graycote Inn Ann Cox Halkett Dr. Rachael M. Hannah John C. Harshbarger Thomas and Mallory Herderick Mrs. Andrea Hersey Mr. and Mrs. Robert Howell Ann Humphrey and Aaron Glazer Karen James, Ph.D. Dr. Margaret O. James Marsha and Bryant Johnson, Jr. Hellmut J. Juretschke, Ph.D. Ms. Ellen Kappes Helen Kim and Noah Leavitt Benjamin L. King Anne and Mark Kozak Dr. Eric R. Lacy Ms. Christine L. Larson Denis and Denise LeBlanc Mr. Ivan B. Lee Mr. and Mrs. Stuart M. Lefkowitz Jerome Lowenstein, M.D.* Mr. and Mrs. Kirk Lurvey Ms. Natalie Martinez* Hoyt and Roberta Matthai Roy A. McMorran Terry and Douglas Mitman Steven and Donna Moore Becky Morrison Chris and Heidi Murphy Marie Nolf Mr. William Osborn and Ms. Lynn Converse Marc C. Owen and Suzette B. Paes Mrs. Stephen Pearson Amy Pelletier Richard Pierson, M.D. Judith and Harry Pinch Arthur J. Pollak Bob and Georgianna Pulver Mrs. Eben W. Pyne Jason Rafferty Sally Randolph Jean Rappaport* and John Dargis Graham Redinger Sandra Rieger, Ph.D. Ms. Diana I. Rigg

Aric N. Rogers, Ph.D. Jarod A. Rollins, Ph.D. Dr.* and Mrs. Robert Rout Maria and Bruce Runnegar Kit* and Anita Sawyer Spain and Richard Secrist Drs. Trevor Shuttleworth and Jill Thompson-Shuttleworth Ms. Christine Smith Ms. Roberta C. Smith Celine and Johannes Spanings David A. Spector, M.D.* Jeffrey and Jill Stoff Marsha and Leroy Tabb Esther C. Testa Mr. James Weeks Mr.* and Mrs. Christopher J. White Dr. Caroline H. Wilson and Mr. Kyle Hampton Natascha A. Wolff, Ph.D. Drs. Mary Kate Worden and Douglas DeSimone Ms. Janet C. Wrestler and Mr. Randall P. Echkoff Aliesa Zoecklein and Kathy Dwyer-Navajas

GIFTS IN-KIND

Gloria and Ian Callard Robert Cserr, M.D. Marydeane and Mark Hanscome Dr. Marion Murray and Mr. Justin Snow Reel Pizza Cinerama

MDI BIOLOGICAL LABORATORY BUSINESS PARTNERS

MDI Biological Laboratory gratefully acknowledges the generous support we receive from our business partners. Alexion Pharmaceuticals Aquaneering, Inc. Bar Harbor Bank & Trust Beckman-Coulter, Inc. Chroma Technology Corp Cross Insurance Dartmouth Toxic Metals Superfund Research Program Excelitas Technologies Life Technologies

Machias Savings Bank Maine Technology Institute MatTek Corporation McKays Public House Natureâ&#x20AC;&#x2122;s One, Inc. New England Biolabs, Inc. Nikon Instruments, Inc. Olympus Corporation Skretting University of Arizona, Superfund Research Program Carl Zeiss Microscopy, LLC

MATCHING GIFT COMPANIES

Nature Conservancy, Maine Chapter Alex C. Walker Foundation David H. Evans Fellowship

Mr. and Mrs. Skip Everitt Dr. and Mrs. Bradley Gale Evangeline R. Haarlow Phyllis R. Monroe, M.D., and David S. Cannom, M.D. Orkand Lectureship Fund

Drs. Jean M. and Joseph W. Sanger David W. Towle Fund for Graduate Students

MDI Biological Laboratory gratefully acknowledges the generous support we receive from employers that match their employeesâ&#x20AC;&#x2122; gifts.

Dr. Betty M. Massie Robert and Joyce Preston

Ameriprise Financial, Inc. Biogen Idec Foundation Doris Duke Management Foundation Elsevier Foundation Matching Gift Program FM Global Foundation GlaxoSmithKline Jefferies LLC Pfizer Foundation Matching Gifts Program

Donor names are italicized

SPECIAL FUNDS

Donor names are italicized Blum-Halsey Fellowship Fund

GIFTS RECEIVED IN MEMORY OF THE FOLLOWING INDIVIDUALS

Drs. Earl O. Butcher and Elmer D. Butcher Mr.* and Mrs. Barry M. Butcher

Helen Cserr Ken Mackie*

Eelgrass Restoration Fund

Anonymous Davis Conservation Foundation Long Cove Foundation, Inc. The Manzanar Project

More than 40 leading scientists, government officials, journalists, educators and top-level representatives from industry, agriculture, and the non-profit sector convened in Salisbury Cove to develop and commit to a concrete action plan that addresses the human health challenges posed by arsenic.

Dr. John W. Boylan Prof.* and Mrs. Klaus W. Thurau

James L. Boyer Fellowship Fund

Ms. Illiana van Meeteren

Human and Environmental Sustainability Summit: Limiting Human Exposure to Arsenic

Charlotte Baltram Mr. Richard Staron

Ashley Fister Cole Brian and Sarah Cole

Terence C. Boylan Lectureship Fund

2014

Mr. J. H. Michael Agar Mr. and Mrs. Fred Carney

Yoakum Fund of the Maine Community Foundation

Phoebe C. Boyer and Todd R. Snyder Ms. Ruth Cserr and Dr. Robert Savell Mr. and Mrs. Frank L. Hohmann III Dr. Betty M. Massie Robert and Joyce Preston Drs. Jean M. and Joseph W. Sanger

Year in review

Sandra Cutler Ms. Elizabeth Cutler William and Margot Doyle Ray and Katharine Stanford Franklin H. Epstein, M.D. George P. Bayliss, M.D. Anatole and Fani Besarab Robert S. Brown, M.D. Sherrie S. Epstein

Identified by the World Health Organization as having the greatest impact on human health of any environmental contaminant, more than 500 million people worldwide drink well water contaminated with arsenic. Results of the Summit were published in the June 2015 issue of Current Environmental Health Reports.

Breaking Through \ 2014 Annual Report \

Year in review

2014

Bioentrepreneurship: Transforming Discoveries into Cures In 2014 all undergraduate fellows at the MDI Biological Laboratory as well as members of the faculty and staff attended a five-day workshop to learn what it takes to bring good innovations to market.

Michael Field, M.D. Dr. and Mrs. James L. Boyer Helen Kim and Noah Leavitt Mr. Irwin List Clive Palfrey* Elizabeth Rodini and Charlie Rudin Elizabeth and Bruce A. Stanton Bruce H. Fraser Mr. Michael Fraser Ms. Roxanne Greenstein Greenstein Family Mr. L. Gordon Hamersley, Jr. Mrs. L. Gordon Hamersley, Jr. Richard Hendrie Mrs. Deborah Hendrie Dr. Barbara Kent Judith T. and Robert P. Adelman Mary M. Brandes* Anne P. R. Dean Dr. Evamaria Kinne-Saffran Dr. Thorsten Althoff* Peter S. Aronson and Marie L. Landry Dr. Jessica H. and Dr. Jack Myers Lewis David Rieck* and Jacy Meyers Stuart Allan and Mary Ellen McAllister Mr. Timothy McAllister and Ms. Beth Lehman

Taught by David Huizenga, Ph.D., J.D., president and chief technology officer of TAO Life Sciences, the course is designed to help participants understand how laboratory discoveries become new therapies or devices that improve human health. Another goal of the course is to help students understand how they can utilize an education in science. “A science background gives you incredible range,” Dr. Kevin Strange told participants. “We want you to stay in Maine. We want you to help drive our economy forward, and we hope this course provides you with some of the skills and background to make that possible.”

YEAR IN REVIEW + DONORS + FELLOWSHIPS

Mr. Steen Meryweather Mr. and Mrs. Michael Blythe Christine Larson Barbara Rappaport Dr. and Mrs. Herbert and Helen Neal William and Marilyn Wilson

Dr. Raymond Rappaport Arthur and Marjorie Dole Drs. Robert* and Sondra Howe Drs. Jean M. and Joseph W. Sanger Anne & Alvin Rieck David Rieck* and Jacy Meyers Edith Rudolf Mr. and Mrs. William G. Foulke, Jr. Mrs. Leon Goldstein Barbara Rappaport Mr. Anthony Schnelling Emy Leeser J.P. Scott, Ph.D. Dr. Mary-Vesta Marston-Scott Margaret Sheldon Mr. and Mrs. Robert C. Bloomberg Coosaw Creek Book Club Marsha and Bryant Johnson, Jr. Barbara Rappaport Ms. Roberta C. Smith Margaret and Warner Sheldon Lura* and Bill Clark Frank Sheldon, M.D., C.M.* Bernice and Leonard Silk Erica Kirsners and Adam Silk Rosemarie Sollano Dr. Josephine A. Sollano Janet H. Spokes Ms. Kate Spokes* Dr. John Stokes, III Jackie Stokes

Clifford Patlak Ms. Margie Patlak* and Mr. Frank Chudnow

GIFTS RECEIVED IN HONOR OF THE FOLLOWING INDIVIDUALS

Ruth Porush Jerome G. Porush, M.D. Ellie W. Ramsey Norman F. Ramsey

Dr. Peter J. Allen Michael and Sheila Humphreys

Donor names are italicized

David H. Evans, Ph.D. Phyllis R. Monroe, M.D., and David S. Cannom, M.D.

Mr. John A. Hays Mr. and Mrs. Robert Sillerman Gary E. Lyons and Jayne Squirrel Karen and Bill Lyons Mr. and Mrs. Conrad and Jean Minnich Thomas and Mallory Herderick Mr. I. Wistar Morris Michael and Sandra Widlitz Neal-Crowell-Walklet families Peggy Crowell Walklet Ms. Clare Stone Mr. and Mrs. William G. Foulke, Jr.

JOHN S. KINGSLEY SOCIETY

Members of the John S. Kingsley Society have graciously supported the MDI Biological Laboratory by making a planned gift. Virginia Agar Dr. Edward J. Benz, Jr., and Dr. Margaret A. Vettese Dr. and Mrs. James L. Boyer Ms. Mary M. Brandes* Ms. Sarah L. Clark Dr. Ben Crocker Mrs. Shelby Cullom Davis° Dr. and Mrs. John N. Forrest, Jr. Drs. Arnold* and Nora Goldschlager Marilyn Brachman Hoffman° Dr. Lowell Hokin Drs. Ellie and Victor Kelmenson Emy Leeser Mr.° and Mrs. Steen L. Meryweather Frank Moya, M.D. Drs. Pam and Stephen Ross Mrs. Ruth Saliba Bodil Schmidt-Nielsen George E. Schreiner, M.D. Mr. and Mrs. William Wilson

2014 FELLOWSHIP RECIPIENTS HIGH SCHOOL RECIPIENTS

James Slater Murphy, M.D. Fellowship

Charles Allen Ethical Culture Fieldston School Mentor: Aric N. Rogers, Ph.D. MDI Biological Laboratory Nash Allan-Rahill Orono High School Mentor: Sandra Rieger, Ph.D. MDI Biological Laboratory

Meagan Currie Greely High School Mentor: James L. Boyer, M.D. Yale University School of Medicine Eve Galen The Brearley School Mentor: Bram V. Lutton, Ph.D.* Endicott College Charles Walker Grimes Cape Elizabeth High School Mentor: Voot Yin, Ph.D. MDI Biological Laboratory Conor Millard Old Town High School Mentor: Voot Yin, Ph.D. MDI Biological Laboratory Hannah Newhall Cape Elizabeth High School Mentor: Karen James, Ph.D. MDI Biological Laboratory Maine Scholars Program

Xingyao Chen MDI High School Mentor: James A. Coffman, Ph.D. MDI Biological Laboratory Anna Ramgren Waterville High School Mentor: Karen James, Ph.D. MDI Biological Laboratory

Mount Sinai School of Medicine

Isaac Elysse High School for Math, Science and Engineering at City College Mentor: Hermann Haller, M.D. Hannover Medical School and MDI Biological Laboratory

UNDERGRADUATE RESEARCH FELLOWSHIP RECIPIENTS Research Experience for Undergraduates (REU)

Mary Badger Smith College Mentor: Jane E. Disney, Ph.D. MDI Biological Laboratory Paola Braña University of Puerto Rico in Bayamón Mentor: Aric N. Rogers, Ph.D. MDI Biological Laboratory

Paige Mundy St. Francis College Mentor: Robert Morris, Ph.D. Wheaton College Hans Pope Wheaton College Mentor: Robert Morris, Ph.D. Wheaton College Maine IDeA Network of Biomedical Research Excellence (INBRE-ME)

Emily Berner Colby College Mentor: Patsy Dickinson, Ph.D. Bowdoin College Megan Chong Bowdoin College Mentor: Hadley Horch, Ph.D. Bowdoin College

Jacob Bruce Southern Maine Community College Mentor: Bram V. Lutton, Ph.D.* Endicott College

Sarah Coreau University of Southern Maine Mentor: Hermann Haller, M.D. Hannover Medical School and MDI Biological Laboratory

Tyler Carrier University of Maine Honors College Mentor: James A. Coffman, Ph.D. MDI Biological Laboratory

Ari Dehn University of Maine at Machias Mentor: Robert Preston, Ph.D. Illinois State University

Alden Dirks Swarthmore College Mentor: Jane E. Disney, Ph.D. MDI Biological Laboratory

Amanda Estes Southern Maine Community College Mentor: Ann McBride, Ph.D. Bowdoin College

Samuel Flores Lehigh University Mentor: Voot Yin, Ph.D. MDI Biological Laboratory

Jason Glynn Southern Maine Community College Mentor: Tamara King, Ph.D. University of New England

Brent Lawson Southern Maine Community College Mentor: Robert Preston, Ph.D. Illinois State University

Lindsay Grumbach University of Maine Mentor: Rebecca Van Benenden, Ph.D. University of Maine

Leah Middleton Mount Holyoke College Mentor: Sandra Rieger, Ph.D. MDI Biological Laboratory

Conor Kirby University of Maine at Farmington Mentor: Joshua Kaveler, Ph.D. Colby College

Breaking Through \ 2014 Annual Report \

Christopher Krasniak Colby College Mentor: Hermann Haller, M.D. Hannover Medical School and MDI Biological Laboratory Hannah Lust University of Maine at Farmington Mentor: Dustin Updike, Ph.D. MDI Biological Laboratory Roshni Mangar College of the Atlantic Mentor: Larissa Williams, Ph.D. Bates College Sienna Mittman Bowdoin College Mentor: William Jackman, Ph.D. Bowdoin College Katherine Paulson Bates College Mentor: Larissa Williams, Ph.D. Bates College Zinta Rutins College of the Atlantic Mentor: James L. Boyer, M.D. Yale University School of Medicine Larissa Sambel Bates College Mentor: T. Glen Lawson, Ph.D. Bates College

GRADUATE STUDENT FELLOWSHIPS David W. Towle Fellowship

Florian Umstaetter Goethe University Mentors: Gert Fricker, Ph.D. and David Miller, Ph.D. University of Heidelberg and National Institute of Environmental Health Services

MDI BIOLOGICAL LABORATORY VISITING FACULTY RESEARCH FELLOWSHIPS Blum-Halsey Fellowship

Zoya Ignatova, Ph.D.

Bowditch Fund

Kenneth D. Poss, Ph.D. James L. Boyer Fellowship

David E. Huizenga, Ph.D., J.D. John W. Boylan Fellowship

Robert Morris, Ph.D.

Terence C. Boylan Fellowship

Robert Morris, Ph.D. Dahlgren Fund

Lisa Bain, Ph.D. William Baldwin, Ph.D. Jorge Contreras, Ph.D. Franklin H. Epstein Fellowship

Kenneth D. Poss, Ph.D.

David H. Evans Fellowship

Riju Shrestha University of Maine Honors College Mentor: Anja Forche, Ph.D. Bowdoin College

Bram V. Lutton, Ph.D.*

Monique Theriault University of Maine Honors College Mentor: Dustin Updike, Ph.D. MDI Biological Laboratory

David E. Huizenga, Ph.D, J.D.

John N. Forrest, Jr., Fellowship

Jorge Contreras, Ph.D. Leon Goldstein Fund

IDeA Network of Biomedical Research Excellence (INBRE)

Paulyn Cartwright, Ph.D. Larissa Williams, Ph.D.

Salisbury Cove Research Fund

Lisa Bain, Ph.D. William Baldwin, Ph.D.

YEAR IN REVIEW + FELLOWSHIPS + TRUSTEES

Bram V. Lutton, Ph.D.* Robert Morris, Ph.D. Bodil Schmidt-Nielsen Fund

Larissa Williams, Ph.D.

U.S. Army Medical Research Acquisition Act (DoD)

Jorge Contreras, Ph.D. Zoya Ignatova, Ph.D. Kenneth D. Poss, Ph.D. Larissa Williams, Ph.D.

2014 TRUSTEES, ADVISORS, FACULTY, AND STAFF TRUSTEES

Peter J. Allen, M.D. Chairman Edward J. Benz, Jr., M.D. Vice-Chairman I. Wistar Morris III Treasurer Alan B. Miller, Esq. Secretary Kevin Strange, Ph.D. Presdient, ex officio Thomas A. Boyd, Ph.D.* Phoebe C. Boyer* Terence C. Boylan* Maximiliaan J. Brenninkmeyer James B. Claiborne, Ph.D. Ruth Cserr* Spencer Ervin, Esq. Joanne R. Firstenberg John A. Hays* Frank L. Hohmann III Lewis B. Kinter, Ph.D.* Alan W. Kornberg, Esq. Anne H. Lehmann* Margaret A. Myers, M.D.* Josephine A. Sollano, MPH, Dr.PH Bruce A. Stanton, Ph.D. Clare Stone

HONORARY TRUSTEE

James B. Claiborne, Ph.D. Georgia Southern University

Bram V. Lutton, Ph.D.* Endicott College

BOARD OF SCIENTIFIC COUNSELORS

James A. Coffman, Ph.D. MDI Biological Laboratory

Rosalind Masereeuw, Ph.D. Radboud University Medical Center

Clare Congdon, Ph.D. University of Southern Maine

Gregory Mayer, Ph.D. Texas Tech University

Jorge Contreras, Ph.D. New Jersey Medical School

David S. Miller, Ph.D. National Institutes of Health/National Institute of Environmental Health Sciences

Emily Leeser

Dr. Barbara S. Beltz, Ph.D. Wellesley College

Marianne Bronner, Ph.D. California Institute of Technology Dennis Brown, Ph.D. Massachusetts General Hospital and Harvard Medical School Donal Thomas Manahan, Ph.D. University of Southern California Andres Villu Maricq, M.D., Ph.D. University of Utah Eric N. Olson, Ph.D. University of Texas Southwestern Medical Center Thomas Rando, M.D., Ph.D. Stanford University School of Medicine Nadia A. Rosenthal, Ph.D. Monash University Alejandro Sanchez Alvarado, Ph.D. Howard Hughes Medical Institute and Stowers Institute for Medical Research Graham Shimmield, Ph.D. Bigelow Laboratory for Ocean Sciences E. Brad Thompson, M.D. University of Texas Medical Branch and University of Houston

FACULTY

Lisa Bain, Ph.D. Clemson University William Baldwin, Ph.D. Clemson University James L. Boyer, M.D. Yale University School of Medicine Paulyn Cartwright, Ph.D. University of Kansas

Christopher Cutler, Ph.D. Georgia Southern University Hugo de Jonge, Ph.D. Erasmus University Medical Center Jane E. Disney, Ph.D. MDI Biological Laboratory David H. Evans, Ph.D. University of Florida Chuck Fidler, Ph.D. MDI Biological Laboratory John N. Forrest, Jr., M.D. Yale University School of Medicine Gert Fricker, Ph.D. University of Heidelberg Hermann Haller, M.D. Hannover Medical School and MDI Biological Laboratory Patrick Hassett, Ph.D. Ohio University David Huizenga, Ph.D., J.D. Tao Life Sciences, Inc. Zoya Ignatova, Ph.D. University of Potsdam Karen E. James, Ph.D. MDI Biological Laboratory George W. Kidder III, Ph.D. MDI Biological Laboratory Benjamin L. King, M.S. MDI Biological Laboratory

Robert Morris, Ph.D. Wheaton College

Year in review

2014

Maine Voters Approve $3 Million Bond Last November Maine voters approved ballot Question 5, providing $3 million to increase biotechnology workforce training, retain and recruit research faculty, and create a drug discovery and development facility to improve human health.

Kenneth D. Poss, Ph.D. Duke University Medical Center and Howard Hughes Medical Institute Robert Preston, Ph.D. Illinois State University Sandra Rieger, Ph.D. MDI Biological Laboratory Jack Riordan, Ph.D. University of North Carolina at Chapel Hill Aric N. Rogers, Ph.D. MDI Biological Laboratory Mario Schiffer, M.D. Hannover Medical School Joseph Shaw, Ph.D. Indiana University Patricio Silva, M.D. Temple University Bruce A. Stanton, Ph.D. Geisel School of Medicine at Dartmouth Kevin Strange, Ph.D. MDI Biological Laboratory Dustin Updike, Ph.D. MDI Biological Laboratory Larissa Williams, Ph.D. Bates College Voot Yin, Ph.D. MDI Biological Laboratory

This award will allow the MDI Biological Laboratory to significantly expand our educational programs by constructing a 6,000 sq. ft. training laboratory and converting our existing 1,700 sq. ft. training laboratory into research space for the recruitment of two additional faculty members. Construction of this facility will also enable us to significantly expand our educational programs, doubling the size of our existing training space, and provide classroom and conference space for up to 100 people. This will allow us to attract larger numbers of course participants, increase the number of course offerings throughout the year, and host small scientific meetings and symposia. Breaking Through \ 2014 Annual Report \

SENIOR STAFF

Kevin Strange, Ph.D. President Patricia H. Hand, Ph.D. Vice President for Administration Jerilyn M. Bowers Director of Development and Public Affairs Chuck Fidler, Ph.D. Director of Education and Staff Scientist Mark A. Hanscome Director of Facilities Claudine D. Lurvey Director of Finance Roy A. McMorran Director of Information Technology Judith C. Sproule Deputy Director of Development

STAFF

Ann-Marie Allen Zebrafish Technician Christopher D. Bailey Systems Developer Jordan M. Bailey Outreach and Education Coordinator Michelle D. Bailey Animal and Instrument Technician Megan Beauchemin Graduate Research Assistant Laura L. Beverly-Staggs Research Assistant Jacqueline C. Bolt Senior Accountant Katherine R. Bowman Custodian Patricia A. Boyce Business Office Assistant Elizabeth A. Brochu Research Assistant 24

YEAR IN REVIEW + STAFF + CREDITS

Bryan J. Butler Physical Plant Staff

Rebecca E. Morrison Research Laboratory Manager

Timothy M. Stearns, M.S. Bioinformatics Analyst

Anne C. Campbell Research Assistant

Anthony R. Mullane Information Technology/Audio-Visual Technician

Paige C. Tanner* Development Office Manager

Heather R. Carlisle Research Assistant Karolina De Groot-Andralojc, Ph.D. Research Assistant MaryLynn FitzSimmons Graduate Research Assistant Bonnie L. Gilfillan Special Events Coordinator Gary L. Gorczyca Physical Plant Staff Ann Cox Halkett Development Writer Tyler D. Ham* Seasonal Animal and Analytical Technician Marydeane Hanscome Seasonal Dining Hall Manager Ellen I. Hartig Research Assistant Amber C. Howard, Ph.D. Postdoctoral Fellow Ashley L. Kelly Research Assistant Heejung Kim, Ph.D. Postdoctoral Fellow Thomas S. Lisse, Ph.D. Research Assistant Nancy D. Madore Dining Hall Assistant Michael A. Marion Research Assistant Judith A. Medlin Education Coordinator

Mark F. Nicknair Physical Plant Staff A, Ph.D.ngela Parton Senior Research Assistant and Environmental Health Safety Officer Amy D. Pelletier Sponsored Programs Accountant Rachel E. Post Annual Giving Officer and Alumni Coordinator Maya J. Rappaport Zebrafish Techinician Kristine Reaman Program Administrator

Leena Mol Thuruthippallil, Ph.D. Postdoctoral Fellow Ashley L. Waldron Research Assistant Toshiki Yamada, Ph.D. Postdoctoral Fellow Shusen Zhu Research Assistant *A lumni of MDI Biological Laboratory’s research training programs ° Deceased † New investigator award recipient, supported by the Salisbury Cove Research Fund ‡ MDI Biological Laboratory Fellowship recipient

Jarod A. Rollins, Ph.D. Postdoctoral Fellow Michael C. Rosenstein, J.D. Scientific Software Engineer Thomas S. Rush Physical Plant Staff

www.mdibl.org

Dmitriy A. Skoog Research Assistant

2014 Donor Report Contributors

Christine M. Smith DNA Sequencing Center Supervisor and Training Laboratory Manager Santina M. Snow Research Assistant Amy L. Somes Senior Executive Assistant

2014

Star Point “Best of Maine” Calling the rock formation on the MDI Biological Laboratory’s northwest shoreline “the most beautiful place on Mount Desert Island you’ve never seen,” Down East magazine featured a picture of Star Point on the cover of its July 2014 issue. Sharing with its readers what the MDI Biological Laboratory community has known for decades, the annual “Best of Maine” issue introduced readers to the “wave-chiseled granite arch as spectacular as any landmark in Acadia National Park”. The article went on to say that Star Point could best be seen by a kayak and suggested potential viewers launch at Hadley Point and paddle to Salisbury Cove, following “the example of Indian guides who showed it off to rusticators 100 years ago.”

To see our full financial report and learn more about our important work, please visit:

Patricia Schroder, Ph.D. Research Assistant

Ashley Smith Research Assistant

Year in review

Editor: Jeri Bowers Concept/Design: Cushman Creative Writers: Jeri Bowers, Maggie Cohn, Connie Mahoney Printer: Penmor Lithographers Photography: Rogier Van Bakel / Eager Eye Karan Cushman Michael Rosenstein MDI Biological Laboratory P.O. Box 35 Salisbury Cove, ME 04672 207.288.3147

Breaking Through \ 2014 Annual Report \

P.O. Box 35 Salisbury Cove, ME 04672 207.288.9880

The MDI Biological Laboratory is a nonprofit, independent biomedical research institution dedicated to improving human health and well-being through basic research, education, and ventures that transform discoveries into cures.

Learn more about how we are making a difference in human health and the environment. www.mdibl.org